gdsc

1.6

0.8

0.0

0.8

1.6

Navitoclax (BCL­2,BCL­XL,BCL­W) MS­275 (HDAC) ZG­10 (IRAK1) VX­11e (ERK) FR­180204 (ERK) AS605240 (PI3K gamma) XL­184 (VEGFR,MET,RET,KIT,FLT1,FLT3,FLT4,TIE2,AXL) Linifanib (RTK) Tivozanib (VEGFR) BX­912 (PDK1 (PDPK1)) GSK429286A (ROCK2) GSK1070916 (AURKB) NPK76­II­72­1 (PLK3) TG101348 (JAK2) Foretinib (MET) BMS­708163 (gamma­secretase) KIN001­055 (JAK3,MNK1) OSI­930 (KIT,VEGFR,PDGFR) KIN001­102 (AKT1) TL­2­105 (CRAF) AC220 (FLT3) UNC0638 (G9a(EHMT2),GLP(EHMT1)) CAY10603 (HDAC6) MPS­1­IN­1 (MPS1) BMS345541 (IKBKB) KIN001­266 (TPL2,COT(M3K8)) XMD13­2 (RIPK) AT­7519 (CDK9) PHA­793887 (CDK­pan) CH5424802 (ALK) YM201636 (PYKfyve(FYV1)) ZSTK474 (PI3K) EKB­569 (EGFR) CAL­101 (PI3K delta) QL­XII­47 (BTK,BMX) JW­7­24­1 (LCK) PIK­93 (PI4K,PI3K) GSK690693 (AKT) QL­X­138 (MNK2,DNAPK,MTOR,BTK,JAK3) OSI­027 (mTORC1/2) PI­103 (PI3K alpha,DNAPK) KIN001­236 (TIE2) Genentech Cpd 10 (AURKA,AURKB) QL­XI­92 (DDR1) KIN001­244 (PDK1 (PDPK1)) STF­62247 (Autophagy) KIN001­270 (CDK9) Y­39983 (ROCK) FMK (RSK) XMD15­27 (CAMK2B,CLK2,DYRK1A,MAST1,STK39) I­BET­762 (BRD2,BRD3,BRD4) CP466722 (ATM) BIX02189 (MEK5) XMD14­99 (EPHB3,CAMK1) KIN001­260 (IKK) Tubastatin A (HDAC6) TPCA­1 (IKK) Masitinib (KIT) BHG712 (EPHB4) NG­25 (TAK) TL­1­85 (TAK) LY317615 (PKCbeta) THZ­2­49 (CDK9) MP470 (PDGFR) NSC­207895 (MDMX) SB52334 (ALK5) Phenformin () CP724714 (ERBB2) QL­VIII­58 (mTOR,ATR) AZD6482 (PI3K beta (P3C2B)) Rapamycin (mTOR) AKT inhibitor VIII (AKT1,AKT2,AKT3) Cetuximab (EGFR) Lapatinib (EGFR,ERBB2) Afatinib (ERBB2,EGFR) Afatinib (ERBB2,EGFR) Erlotinib (EGFR) Gefitinib (EGFR) TAK­715 (p38a) QL­XII­61 (BMX,BTK) KIN001­135 (IKKE) Tamoxifen (ER) Temozolomide (DNA akylating agent) GDC0449 (SMO) Pyrimethamine (Dihydrofolate reductase (DHFR)) JQ1 (BRD2,BRD3,BRD4) UNC0638 (G9a(EHMT2),GLP(EHMT1)) Methotrexate (Dihydrofolate reductase (DHFR)) BAY 61­3606 (SYK) PAC­1 (CASP3 agonist) 5­Fluorouracil (DNA antimetabolite) UNC1215 (L3MBTL3) CX­5461 (RNA Pol I) AMG­706 (VEGFR,RET,c­KIT,PDGFR) BIRB 0796 (Androgen receptor (ANDR)) EX­527 (SIRT1) FTI­277 (Farnesyl­transferase (FNTA)) IOX2 (EGLN1) JQ12 (HDAC) Lenalidomide (TNF alpha) T0901317 (LXR) Bicalutamide (Androgen receptor (ANDR)) VX­702 (p38) SGC0946 (DOT1L (Q8TEK3)) Ruxolitinib (JAK1,JAK2,TYK2) VNLG/124 (HDAC,RAR) SB 505124 (TGFbetaR­I (ALK5)) Zibotentan (Endothelin A Receptor) IPA­3 (PAK) GW­2580 (cFMS) rTRAIL (DR4,DR5) GSK1904529A (IGF1R) AS601245 (JNK) Bexarotene (Retinioic acid X family agonist) Tipifarnib (Farnesyl­transferase (FNTA)) VX­680 (AURKA,AURKB,AURKC,FLT3,ABL1,JAK2) ZM­447439 (AURKB) PF­562271 (FAK) Sunitinib (PDGFRA,PDGFRB,KDR,KIT,FLT3) S­Trityl­L­cysteine (KIF11) HG­5­113­01 (LOK,LTK,TRCB,ABL(T315I)) Bosutinib (SRC,ABL,TEC) PD­0332991 (CDK4,CDK6) BMS­509744 (ITK) PD­173074 (FGFR1,FGFR3) SB 216763 (GSK3A,GSK3B) BX­795 (TBK1,PDPK1,IKK,AURKB,AURKC) PHA­665752 (MET) Cytarabine (DNA synthesis) GSK269962A (ROCK1,ROCK2) Axitinib (PDGFR,KIT,VEGFR) CCT007093 (PPM1D) Olaparib (PARP1,PARP2) Olaparib (PARP1,PARP2) AG­014699 (PARP1,PARP2) Talazoparib (PARP1,PARP2) JNK Inhibitor VIII (JNK) LFM­A13 (BTK) QS11 (ARFGAP) Etoposide (TOP2) Veliparib (PARP1,PARP2) MLN4924 (NEDD8­activating enzyme (NAE)) BMS­708163 (gamma­secretase) NSC­87877 (SHP­1 (PTPN6),SHP­2 (PTPN11)) Bleomycin (DNA damage) OSU­03012 (PDK1 (PDPK1)) GSK­650394 (SGK3) Bleomycin (50 uM) (DNA damage) SL 0101­1 (RSK,AURKB,PIM3) 681640 (WEE1,CHEK1) KU­55933 (ATM) Bicalutamide (Androgen receptor (ANDR)) YK 4­279 (RNA helicase A) Cisplatin (DNA crosslinker) RO­3306 (CDK1) CCT018159 (HSP90) Embelin (XIAP) NU­7441 (DNAPK) JNJ­26854165 (MDM2) XMD8­92 (ERK5) PFI­1 (BRD2,BRD3,BRD4) Parthenolide (NFKB1) XMD11­85h (BRSK2,FLT4,MARK4,PRKCD,RET,SPRK1) GSK269962A (ROCK1,ROCK2) CMK (RSK) piperlongumine (Increases ROS levels) Imatinib (ABL,KIT,PDGFR) GNF­2 (ABL (T315I)) Crizotinib (MET,ALK) Bryostatin 1 (PRKC) Sorafenib (PDGFRA,PDGFRB,KDR,KIT,FLT3) JQ1 (BRD2,BRD3,BRD4) Nilotinib (ABL) WZ­1­84 (BMX) Saracatinib (SRC,ABL1) TGX221 (PI3K beta) A­770041 (SRC family) WH­4­023 (SRC family,ABL) Dasatinib (ABL,SRC,KIT,PDGFR) Salubrinal (GADD34­PP1C phosphatase) MK­2206 (AKT1,AKT2) GDC0941 (PI3K) Pazopanib (VEGFR,PDGFRA,PDGFRB,KIT) AZD6482 (PI3K beta (P3C2B)) GDC0941 (PI3K) XAV939 (TNKS1,TNKS2) Z­LLNle­CHO (gamma­secretase) Cyclopamine (SMO) CGP­082996 (CDK4) XMD8­85 (ERK5 (MK07)) DMOG (Prolyl­4­Hydroxylase) CHIR­99021 (GSK3B) CHIR­99021 (GSK3B) AP­24534 (ABL) HG­6­64­1 (BRAFV600E,TAK,MAP4K5) ATRA (Retinoic acid and retinoid X receptor agonist) GW 441756 (NTRK1) FH535 (unknown) EHT 1864 (Rac GTPases) PF­4708671 (p70 S6KA) Vorinostat (HDAC inhibitor Class I,IIa,IIb,IV) Roscovitine (CDK family) AICAR (AMPK agonist) BMS­536924 (IGF1R) TAE684 (ALK) BMS­754807 (IGF1R) Lisitinib (IGF1R) BMS­536924 (IGF1R) HG­5­88­01 (EGFR,ADCK4) Nutlin­3a (­) (MDM2) CI­1040 (MEK1,MEK2) selumetinib (MEK1,MEK2) Trametinib (MEK1,MEK2) selumetinib (MEK1,MEK2) RDEA119 (MEK1,MEK2) PD­0325901 (MEK1,MEK2) RDEA119 (MEK1,MEK2) PLX4720 (BRAF) SB590885 (BRAF) PLX4720 (BRAF) (5Z)­7­Oxozeaenol (TAK1 (MAP3K7)) Dabrafenib (BRAF) AZ628 (BRAF) 1 5 9 10 2 4 3 7 6 8