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A Preliminary Review of Studies on Adaptogens

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A Preliminary Review of Studies on Adaptogens Liao et al. Chin Med (2018) 13:57 https://doi.org/10.1186/s13020-018-0214-9 Chinese Medicine REVIEW Open Access A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng‑like herbs used worldwide Lian‑ying Liao1,2, Yi‑fan He1,2, Li Li1,2, Hong Meng1,2, Yin‑mao Dong1,2, Fan Yi1,2* and Pei‑gen Xiao3 Abstract Modern studies have shown that adaptogens can non-specifcally enhance the resistance of human body under a wide range of external stress conditions with a multi-targeted and multi-channel network-like manner, especially by afect the immune-neuro-endocrine system and the hypothalamic–pituitary–adrenal axis. This review article draws the attention to the relationships of adaptogens, tonics from traditional Chinese medicine (TCM) and ginseng-like herbs worldwide, which all have similar plant sources and clinical applications. To clarify the sources and pharmaco‑ logical mechanisms of these plant-originated adaptogens, which will provide useful information for the utilization of adaptogens to improve the human health. Meanwhile, the TCMs and the world-wide ginseng-like herbs from each region’s ethnopharmacology will be benefcial modernization and globalization. Keywords: Adaptogen, Immune-neuro-endocrine system, HPA axis, Tonics, Ginseng-like herbs worldwide Introduction adaptogens must not harm the normal functions of the Te term of adaptogen was frst proposed in 1940 by a human body. scientist from the USSR, namely, N. Lazarev, when he Ten I.Brekhman, a Soviet scientist, studied ginseng in described Schisandra chinensis (Turcz.) Bail. and other approximately 1950, he extended the concept of adapto- herbs with the following defnition: plant-originated gens as follows: medicines that have similar functions as adaptogens that can non-specifcally the enhance human adaptogens can help the body maintain ideal homeostasis body. According to the primary defnition of adapto- under adverse or stressful conditions. gens, these substances must meet three criteria: frst, Again, Brekhman and Dardymov further defned plant- adaptogens must to be non-specifc and must assist the originated adaptogens in 1969 [1]. According to this def- human body in resisting a wide range of adverse condi- nition, plant-originated adaptogens meet four criteria: tions, such as physical, chemical or biological stress. frst, plant-originated adaptogens must reduce the harm Tese may include environmental pollution, climate caused by stressed states, such as fatigue, infection, and change, radiation, infectious diseases, and interpersonal depression; second, plant-originated adaptogens must disharmony. Second, adaptogens must maintain homeo- have positive excitatory efects on the human body; third, stasis in humans, that is, these substances can ofset or in contrast to traditional stimulants, the excitatory efects resist physical disorders caused by external stress. Tird, produced by plant-originated adaptogens must not cause side efects such as insomnia, low protein synthesis, or excessive energy consumption; fourth, plant-originated *Correspondence: [email protected] adaptogens must not harm the human body. 2 Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, No. 11/33, Fucheng Road, In the 1990s, a group of scientists, comprised of Hilde- Haidian District, Beijing 100048, People’s Republic of China bert Wagner, George Wikman and Alexander Panossian, Full list of author information is available at the end of the article performed many studies on adaptogens and proposed the © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat​iveco​mmons​.org/licen​ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creat​iveco​mmons​.org/ publi​cdoma​in/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Liao et al. Chin Med (2018) 13:57 Page 2 of 12 following defnition: adaptogens are natural bioregulators frst, these adaptogens typically exert infuence on the that increase the ability to adapt environmental factors immune, nervous and endocrine systems; second, these and avoid the damage caused by those factors. In fact, the adaptogens do not infuence the HPA axis, directly; advantage of adaptogens are they minimized the bodily third, these plant-originated adaptogens include fatty response to stress, reducing the negative reactions during acids, sterols and phenols; fourth, these substances can the alarm phase and eliminating, or at least decreasing, enhance anabolism. While the secondary adaptogens the onset of the exhaustion phase that is part of the so- may meet most of the qualifcations of primary adap- called general adaptation syndrome [2]. togens, but they have yet to be studied extensively [5]. With continuous research for more than half a cen- Another category is adaptogen companions, which tury, the concept of adaptogens has been continuously may not satisfy all the traditional standards but can modifed and perfected. In 1998, the American Food and have benefcial efects on the HPA axis and on anabo- Drug Administration (FDA) [3] defned an adaptogen as lism to support the functions of adaptogens. Although a new kind of metabolic regulator that has been proved these kinds of medicinal plants have similar functions to help in environmental adaptation and to prevent exter- as the other two kinds of adaptogens mentioned above, nal harms. Adaptogen has been generally used as a func- these plants can not formally be called adaptogen. tional term. Tus, these plants are classifed as adaptogens compan- Yance, an American herbal doctor, held a view that ions because they can act synergistically with the other adaptogens can improve our ability to recognize, two kinds of adaptogens mentioned above, thereby respond, recover, and restore or regenerate. He divided improving the efects of the adaptogens [5]. adaptogens into three categories, including primary Currently, studies have confrmed that the following adaptogens, secondary adaptogens, and adaptogen com- plants are true adaptogens: Panax ginseng C.A.Mey, panions, based on his clinical experience [4]. Primary Schisandra chinensis (Turcz.) Baill., Acanthopanax adaptogens are consistent with the traditional defnition senticosus (Rupr. et Maxim.) Harms, Rhodiola crenu- of adaptogens and satisfy specifc criterias. Te criterias lata (Hook. f. et Toms) S.H.Fu, and Lepidium meyenii contains: abundant scientifc research confrmed their Walp. adaptogenic characters, guarantee of general resistance According to web of science database, we searched the and non-specifc action in the human body, maintenance key word, adaptogen. Based on the analysis of results, we or restoration for homeostasis, and adverse- or toxic- got a conclusion that more and more researches focus on efects after prolonged use [5]. this feld over past 10 years and it showed an increasing Furthermore, some precise scientifc experiments tendency from 1999 to 2018, which profles that it is still demonstrated that adaptogens can enhance the resist- a worthwhile direction to explore. Furthermore, we also ance of human body against various external stimuli as found out that the many published articles concentrated non-specifc regulators. Adaptogen function mainly by on the direction of pharmacology pharmacy, biochem- afecting the hypothalamic–pituitary–adrenal (HPA axis) istry molecular biology, plant sciences and agriculture. in response to stimulation by external stress. Primary It is still worthy to show its historical development and adaptogens can not only maintain or recover homeosta- fnd out the relationships among adaptogen and ton- sis and allostasis but can also promote anabolic recovery. ics and ginseng-like herbs worldwide, which can give a Primary adaptogens can produce positive stress response hint to further research in plant-originated adaptogen. and the associated hormone expression. Primary adap- Summarized the results of previous studies and our own togens strengthen the functioning of each systems, pro- researches focused on tonics from TCM, we launched mote optimal response, promote recovery of function, out our understanding of adaptogen: Herbs which can and help regulate energy use by improving the function non-specifc and non-toxicity help human body resist of neuroendocrine system and enhancing cellular energy the environmental stress to maintain a homeostasis. transfer, which can make body utilize oxygen, glucose, Te mechanism may multi-targets and multi-channel lipids and proteins very efectively, thus providing us with network to the neuroendocrine system. Te adaptogens a steady supply of energy [4]. with tonics from TCM and the world-wide ginseng-like Another category of adaptogens is secondary adapto- herbs have similar phytochemical and pharmacological gens, which are consistent with most traditional defni- properties. tions of adaptogens but not all of the criteria of primary adaptogens. Secondary adaptogens cannot infuence the HPA axis directly; however, these adaptogens can The functions of adaptogens afect the immune, nervous and endocrine systems. Adaptogens can afect diferent tissues and organs, and Secondary adaptogens share several common
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