2014 ANNUAL REPORT CURES START HERE CURES START HERE At Fred Hutch, our sights are set on a cancer-free future. This goal drives us to develop tomorrow’s breakthroughs, today. As a Fred Hutch supporter, you propel our lifesaving research. Because of you, revolutionary discoveries, better treatments and healthier lives around the world are possible. Thank you.

2 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT MESSAGE FROM DR. MARK GROUDINE ACTING PRESIDENT AND DIRECTOR

Photo by Bo Jungmayer / Fred Hutch

To all those who partner with us to make new cures possible, thank you.

I joined Fred Hutch in 1979, and since value of high-quality research proof they can succeed. In contrast, then, I’ve seen cures start here many times philanthropic contributions fund novel, over. Much of our success in generating A yeast enzyme re-engineered by Fred ahead-of-the-curve ideas. With that seed discoveries that produce meaningful Hutch scientists to work in humans funding, our investigators can generate improvements in human health is due that has become part of a new, sufficient preliminary data to obtain more to the Hutch’s uniquely broad spectrum targeted cancer therapy now being conventional funding. In addition, the of research, from explorations of basic tested in patients with glioblastoma dollars raised from philanthropy permit biology to patient trials of new medicines us to hire the best and brightest new to population-based studies that shape You’ll also read about some of the investigators, who bring new ideas and public health guidelines. people who support and champion Fred approaches to the Hutch that will lead to Our annual report provides examples of Hutch by jump-starting research projects more cures in the years ahead. that breadth, including stories on: in immunotherapy or global oncology, for Finally, I want to thank Dr. Larry Corey, example, or by rallying friends to join in who ended his tenure as president and Umbilical cord blood transplantation, Obliteride. director this year to return to his laboratory a technique — built on fundamental To all the individuals and organizations and focus on research. It was my pleasure breakthroughs made in Fred Hutch who partner with us to make new cures to work alongside my close friend and labs two decades ago — that is possible, thank you. Your support is truly colleague while he led Fred Hutch. It is our providing cures for cancer patients catalytic to Fred Hutch research. For good fortune that Larry will remain at the who had no other options example, approximately 90 percent of our Hutch as president and director emeritus. annual research budget is derived from Thank you again to a community of An unanticipated discovery about federal agencies such as the National contributors as diverse and dedicated as combined hormone therapy and the Institutes of Health. As you may know, the researchers you support. risk of breast cancer that emerged federal funding for biomedical research from the Hutch-based Women’s Health is becoming more precarious. Moreover, Initiative — findings that have since grants from these sources are committed saved hundreds of thousands of lives to funding studies that are already far and that also underscore the economic enough along to have documented

3 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CATALYZING IMMUNOTHERAPY RESEARCH

Fred Hutch’s Dr. Stanley Riddell (right) and his team members, Tyler Hill (left) and Dr. Daniel Sommermeyer (middle), are pioneering new approaches to battle cancer using killer immune cells ­­— thanks in part to a boost from benefactors Rae and Mark Lembersky. Photo by Bo Jungmayer / Fred Hutch

Dr. Stanley Riddell’s five-year partnership with Rae and Mark Lembersky has brought a promising cancer immunotherapy to the brink of clinical trial

By Dr. Rachel Tompa ROR1 protein in abundance, while healthy mature B cells are not, making it an ideal candidate target for their engineered killer T cells. Rae and Mark Lembersky met Fred Hutch’s Dr. Stanley Riddell at “What was scheduled to be a brief meeting turned into a long a pivotal point of Riddell’s research — he had just identified ROR1, discussion,” Mark said, as he was drawn into the innovation of a protein on certain leukemia cells that would later turn out to be a Riddell’s immunotherapy methods and learned about the difficulty linchpin in a novel immunotherapy approach with the potential to the research team faced in garnering traditional funding for their help thousands of patients with many types of cancer. “potentially breakthrough but unproven ideas.” Riddell and his Fred Hutch colleagues are world leaders That’s where the Lemberskys stepped in. A few weeks after in adoptive T-cell therapy, a technique that reprograms killer meeting with Riddell, they made a gift that launched the ROR1 immune cells to specifically recognize and eliminate cancer cells, project and supported the team’s first year of research. With sparing healthy cells from the toxic damage of traditional cancer that initial support, the scientists crafted the first CARs specific treatments. When the Lemberskys were first introduced to Riddell, for ROR1 and conducted preliminary experiments to better his team had made great strides designing T cells loaded with understand this potentially life-changing but mysterious protein. chimeric antigen receptors (CARs), laboratory-engineered proteins Less than a year later, Riddell used that preliminary data to obtain that coat the surface of T cells and guide them to malignant cells by a National Institutes of Health grant to support his ROR1 and other homing in on cancer-specific proteins. immunotherapy research worth 20 times the Lemberskys’ initial The Lemberskys, already long-time supporters of Fred Hutch, investment. connected with Riddell because Mark’s aunt had been diagnosed Riddell’s team was the first to show the promise of ROR1 for with chronic lymphocytic leukemia (CLL), a blood cancer that afflicts T-cell therapy, and in the year following began testing the therapy’s B cells of the immune system. Riddell and his team were developing safety and cancer-killing power in preclinical models. They also therapies for CLL and had just found that CLL cells are coated with continued their exploration of ROR1’s role in cancer and found, to

4 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > their surprise, that the protein dots the surface of many other types of cancer cells, including mantle cell lymphoma, lung, pancreatic and prostate cancer, and some types of breast and brain cancer. Immunotherapy takes off Riddell and his colleagues were delighted to find that what Dr. Stanley Riddell’s groundbreaking research on started as a possible therapy for one type of leukemia might have a ROR1 is just one advance in Fred Hutch’s decades- much broader reach. Riddell has since led groundbreaking research long history of harnessing the immune system showing for the first time that T cells bearing ROR1-CARs can to save lives. This year, Fred Hutch’s leadership in eliminate breast cancer and mantle cell lymphoma in the laboratory. immunotherapy led to two landmark developments Although Riddell received government support for part of his that are opening new doors to cancer cures: work, there were other funding gaps along the path from this initial research to clinical trial. Traditional granting agencies simply don’t In December 2013, Fred Hutch partnered cover every stage of translational research, and that’s why Riddell is with Memorial Sloan Kettering Cancer Center so thankful for the Lemberskys’ continued partnership. For example, and Seattle Children’s Research Institute to a gift from the Lemberskys allowed Riddell to develop a technique launch Juno Therapeutics Inc. The cancer to examine ROR1’s activity in solid tumors, a technique that is immunotherapy startup, which raised $310 essential to bring the power of ROR1 immunotherapy to cancers million in investments its first year, will leverage beyond leukemia. its impressive array of scientific talent and “Fortunately for us they continued to catalyze the project at very technology to more rapidly advance promising critical stages,” Riddell said. “At every step where we faced a need to new treatments to patients. generate critical preliminary data to move the project forward, they were there for us.” In April 2014, Fred Hutch received its largest Now, Riddell and his team are poised to bring ROR1- donation ever: a $20 million gift from the Bezos immunotherapy to patients with a clinical trial that will launch in family to boost immunotherapy research and early 2015. Another gift from the Lemberskys has allowed Riddell to extend the successes seen so far in patients include patients with solid tumors in the trial, in addition to blood with blood cancers to those with lung, colon, cancer patients. breast, pancreatic, ovarian and other solid- Mark’s aunt is still alive and thriving, and although the tumor cancers. Lemberskys originally connected with Riddell to find out more about CLL, they are happy their investment has the potential to reach even more people. “We were very motivated to help Stan’s work that not only might help CLL sufferers but also a broad array of cancer patients. That remains our motivation today,” Mark said. Riddell is grateful for the Lemberskys’ financial support — “We would probably never have started with ROR1 if it wasn’t for that initial gift,” he said — but he also deeply appreciates their engagement with him and his research. “They really want to know that you’re working hard on this, and they want to understand what your obstacles are and how they can help solve them. It’s that kind of partnership that really makes it a lot of fun,” Riddell said. “The NIH does not take a personal interest, whereas the Lemberskys are as excited as we are at the prospect of making this idea a reality.” The partnership has also been rewarding for the Lemberskys. “Interacting with Stan has been a real pleasure,” they said. “Plus, we have been given the opportunity to play a small part in what may Dr. Stanley Riddell, left, and Alex Salter discuss their latest well become a major safe and effective treatment for not only CLL, research findings in Riddell’s immunotherapy lab in Fred Hutch’s but a number of other cancers as well. What more could donors ask Clinical Research Division. Photo by Bo Jungmayer / Fred Hutch for?”

5 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT ‘MIRACLES REALLY DO HAPPEN IN THE LABS’

Dr. Larry Corey stepped down as Fred Hutch president and director this year to return to the lab and his passion of hands-on research. Photo by Robert Hood / Fred Hutch

Dr. Larry Corey steps down as Fred Hutch president and director, sets sights on achieving an AIDS-free world through hands-on research

By Linda Dahlstrom “The Hutch’s loss of Larry as president and director is a major gain for the field of HIV vaccine research,” said Dr. Anthony S. At the helm of Fred Hutch, Dr. Larry Corey championed high- Fauci, director of the National Institute of Allergy and Infectious impact initiatives and encouraged everyone around him to share Diseases, part of the National Institutes of Health. the story of Fred Hutch’s lifesaving research and the people Dr. Robert Day, former president and director of Fred Hutch, conducting it. was one of the people who recruited Corey as a researcher in After three and a half successful years leading Fred Hutch, 1996. Corey stepped down June 30 as president and director. “I’m a big fan of Larry. This is a very difficult time for biomedical “I’ve loved this job. The notion that cures start here now research and he’s dealt with that difficulty very well,” Day said. permeates the place,” Corey said. “We are no longer looking “Now he’ll be able to apply his full attention (to research) and I backward — we are looking forward.” think it’s a good time for that.” Corey, who for decades dedicated his career to unlocking the While better treatments have been developed for people living secrets of HIV and AIDS and other infectious diseases and finding with AIDS, Corey has set his sights on a vaccine. He’s the founder treatments that have now saved countless lives, has returned to and director of the HIV Vaccine Trials Network, a collaboration of his passion — making a difference through hands-on research. scientists around the world working toward an HIV vaccine. Corey is now working full-time with his lab and colleagues in “I want my grandchildren to grow up in the AIDS-free world the Vaccine and Infectious Disease Division. He’s a member of that I did,” Corey said. “I want them to be able to get vaccinated the faculty, and has the title of president and director emeritus. for HIV and for herpes and to not have to worry. That’s the dream.” Dr. Mark Groudine is serving as Fred Hutch’s acting president and There is much to do, and after all these years, Corey still feels director while the Board of Trustees conducts a national search the same sense of urgency and is eager to get back to it. for Corey’s successor. “Miracles really do happen in the labs,” he said.

6 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT FROM YEAST TO BRAIN, ENGINEERING A NEW CANCER TREATMENT

Dr. Barry Stoddard and his team used a new approach to engineer a molecule in yeast that is now being tested to treat brain cancer. Photo by Scott Streble for Fred Hutch

Enzyme redesigned at Fred Hutch makes headway in clinical trial

By Susan Keown Stoddard’s original goal was to figure out this enzyme’s structure and how it works. Once he’d done that and successfully Some engineers build skyscrapers, but Dr. Barry Stoddard engineered a new version, his team shared their redesigned works on a much smaller scale. Using computer modeling enzyme with the scientific community, which is how it made its software and genetic manipulation techniques, Stoddard tinkers way into a starring role in the glioblastoma trial. with molecules. This trial is “a really good example of a basic scientific study Today, one molecule reengineered in the Stoddard Lab is unexpectedly getting turned into a clinical application,” said getting its chance to prove itself as part of a groundbreaking new Stoddard. therapy for glioblastoma, a fast-growing brain cancer. It’s still too early to know whether the treatment will shrink the Last year, a San Diego-based biotech company began early- tumors as intended or if it might need further refining, but some phase clinical trials of a yeast enzyme reengineered in 2005 patients have shown encouraging improvements. by Stoddard and his collaborators. (An enzyme is a molecule “That there are people walking around with glioblastomas that that helps the chemical reactions of life happen.) Thanks to are getting therapeutic benefit, partly from something we worked three tweaks that the Stoddard Lab made to its structure, the on, just blows my mind,” said Stoddard, whose mother died of engineered enzyme is more stable and more precisely honed to glioblastoma shortly after he came to the Hutch. “To have been its target, which has made it better for use in human therapeutics. able to contribute in a small way to efforts to fight such a terrible “At that time, that type of protein engineering hadn’t been disease has been a tremendous blessing.” done before,” Stoddard said. “Structure-based, computer-aided redesign to alter the properties of an enzyme, to make it better.” In the ongoing trials, researchers infect patients’ cancer cells THROUGH THEIR GENEROUS SUPPORT AT THE 2013 (and not their healthy cells) with a special virus that instructs the HUTCH HOLIDAY GALA, AND AS MEMBERS OF FRED cells to make the engineered enzyme. Then, patients take pills HUTCH’S PRESIDENT’S CIRCLE, BRUCE AND PEGGY containing a compound that is harmless to normal human cells, WANTA HELP FUEL BASIC SCIENCE RESEARCH AT but fatal to the cancer cells once their new enzyme converts the FRED HUTCH — LIKE DR. STODDARD’S — THAT PAVES compound into a poison. Unlike conventional chemotherapy, this THE WAY TO LIFESAVING MEDICAL ADVANCES. type of targeted gene therapy leaves healthy cells untouched.

7 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT BRINGING THE CURATIVE POWER OF CORD BLOOD TO THE WORLD

Dr. Colleen Delaney (far left) updates (L to R) Daniella, David and Jacquie Bayley on her team’s research progress, along with lab technician David Oliver (far right). Photo by Bo Jungmayer / Fred Hutch

Bayley family supports Dr. Colleen Delaney’s quest to make cord blood transplantation available to all who need it

By Dr. Sabrina Richards each sample). Her goal is to create an off-the-shelf cord blood product available to anyone, anywhere, in need of a transplant — Bone marrow transplantation was pioneered at Fred Hutch irrespective of their genetic make-up. as a cure for many types of leukemias and lymphomas. This Delaney’s progress has been impressive — thanks to critical groundbreaking procedure has since been performed over 1 private support, including contributions from the Bayley family, million times worldwide, but hope for a cure remains out of which shares her vision of a future where no transplant patient reach for many patients who lack genetically matched donors. To goes wanting. It is a dream close to their hearts. help them, Fred Hutch is again nurturing a future cure: a next- In 2004, Jacquie and Björn Bayley’s 17-year-old son, David, generation blood stem cell transplant that could put the lifesaving noticed an unusual lethargy during soccer practice. Blood tests treatment within reach of any patient in need. The treatment showed he had acute myeloid leukemia. After initially successful relies on umbilical cord blood. chemotherapy, he relapsed in 2006. Doctors prescribed a bone Cord blood harbors the same blood stem cells that can replace marrow transplant. a patient’s cancerous bone marrow, but it doesn’t need to be David’s medical team found a donor in Germany whose DNA nearly as well-matched to the patient as adult blood stem cells matched at nine out of ten genetic sites. The transplant worked. do. This makes it a good option for patients who can’t find a “I feel so lucky I came through it so well,” explains David, who’s matched adult donor, many of whom are ethnic minorities or of been cancer-free ever since, with only one lingering side effect, mixed race. a slight dryness to his eyes, to remind him of the procedure. “But Dr. Colleen Delaney, who heads Fred Hutch’s Cord Blood I saw many who weren’t as successful.” He knew patients whose Program, is designing a product that harnesses cord blood’s transplants didn’t “take” or who struggled with debilitating graft- advantages (no need for perfect matching) while overcoming its vs.-host disease, a complication in which donor immune cells disadvantage (the low number of key blood stem cells found in attack the patient’s healthy tissues.

8 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > The Bayleys knew they wanted to give back and help other against infection and see their chemo-impaired immune systems cancer patients in need. “I firmly believe if you can give, you do,” rebound in just a couple weeks, rather than a month or more. This explains Jacquie. can make a huge difference to the patient’s quality of life. They turned to Fred Hutch as part of the community that As the possible curative applications keep unfolding, Delaney provided care through David’s illness. As the family considered keeps dreaming bigger, and the Bayleys are helping propel her three potential projects — two that addressed cancer survivors’ dreams forward. In particular, their contributions have supported concerns, and one postdoctoral fellow related to Delaney’s Dr. Jianqiang Li’s ambitious cord blood investigations into therapy — David double cord-blood had an epiphany: transplantation. In this Delaney’s research procedure, patients provided hope for a are given cord blood gentler, yet curative, from two different option for cancer donors. Double cord patients. Not only blood transplants could cord blood help have a higher success save lives, it would rate than transplants help improve them by from a single donor dramatically reducing and they’re better at the complications preventing cancer that plagued relapse. even successful Delaney and her transplants. team demonstrated “I thought, if Dr. that this is because Delaney’s project of a battle waged succeeds, you between the immune wouldn’t need the cells found in each other two projects,” cord blood sample; recalls David. one donor “wins” And so a the battle, and these collaboration was donor’s cells become The Bayley family’s collaboration with Dr. Delaney has accelerated important insights into cord born. Over the years, blood’s potential. Photo by Bo Jungmayer / Fred Hutch the source of new, funds from the Bayley healthy bone marrow. Family Foundation “It’s like two have enabled Delaney to buy vital equipment, retain critical different people fighting inside another person,” explains Delaney, laboratory staff, continue her clinical trials, and support basic “and the winner becomes even stronger in its ability to fight the research investigating exactly how cord blood works its magic. cancer.” And in her hands, the material is magical. Building on But which cells will win? And how does the competition fundamental discoveries first made in Fred Hutch labs about itself help the winner go on to defeat the cancer? Li is how blood stem cells divide and mature, Delaney developed a working to answer these questions. His insights will help method to multiply, or expand, the few precious blood stem cells transplant oncologists pick the winning donor cells even before from the teaspoon-sized cord blood samples up to 500 times transplantation, and perhaps enable Delaney’s team to develop a over. The expanded product protects transplant patients against cord blood-based immunotherapy that can better target cancer chemotherapy toxicity, infection and cancer relapse, improving cells and enhance protection against relapse. not only survival but quality of life. It is this vision — to understand and utilize all of cord blood’s In addition, Delaney discovered that cord blood’s healing power potential, sparking countless more cures — that the Bayleys is not limited to transplant patients. Chemotherapy patients continue to support, year after year. As Jacquie explains, “I think who receive her expanded cord blood cells are also protected it’s the way of the future.”

9 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT IN PICTURES: GETTING INVOLVED TO GET CURES STARTED

Fred Hutch employee Andrea Towlerton is a curestarter — on and off the clock

By Dr. Sabrina Richards

TOP: Research technician Andrea Towlerton trekked from Midland, Michigan, to Seattle to join Dr. Hootie Warren’s lab at Fred Hutch four years ago. Towlerton had studied everything from bats to nanotechnology, but when she learned of Fred Hutch’s lifesaving clinical trials from the cancer patients with whom she volunteered in her hometown, she made it her mission to be a part of bringing cures to the bedside. “Dr. Warren combines passion and compassion: He’s enthusiastic about research but also really understands the sacrifices patients make,” said Towlerton. “It’s truly a gift to wake up each day and know that what you’re doing is helping others.” Photo by Bo Jungmayer / Fred Hutch

RIGHT: In the Warren Lab, Towlerton and her colleagues focus on developing immunotherapy strategies for cancer patients. Not long after starting her new position, she joined Innovators Network, a group of young professionals committed to funding early- stage research, to get more involved in the Fred Hutch community and learn about the fantastic research being done across her new workplace. “Working in this environment is absolutely awesome: People work here because their motivation in life is to help others. IN helps keep these brilliant minds here.” Fred Hutch file photo

10 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > Why give back so much personal time — and a seemingly endless supply of energy — to the same place where she already devotes so many hours in the lab working on cancer cures? “I feel it’s important to give back to a place that gives so much to patients,” she said. “Every therapy starts with research. In our lab, we understand the importance of research and clinical care working together, and private philanthropy helps support our quest to create lifesaving therapies.” Towlerton’s dedication to her colleagues and the patients they’re striving to help runs deep — and is now an enduring piece of Fred Hutch itself. The engraved brick she bought as a Christmas present “to commemorate the Warren Lab and every amazing scientist who passes through” sits in the courtyard outside her building and serves as a daily reminder of the mission that unites all Fred Hutch supporters Fred Hutch File

ABOVE: “It takes teamwork to do science right, and giving back can be part of a team effort too,” said Towlerton. Last year, she and her lab mates joined the “T cells” immunotherapy team to ride and raise money for cancer research through Obliteride, Fred Hutch’s annual bike riding fundraiser. “It was a whole new — and very fun — way for us to support innovative research together,” she said. Photo courtesy of Andrea Towlerton

RIGHT: Her 50-mile ride supporting cancer research came just three weeks after a 19,340-foot climb. As part of another Fred Hutch fundraiser, the Climb to Fight Breast Cancer, Towlerton summited Mount Kilimanjaro in Tanzania. That adventure combined two of her loves, mountain climbing and giving to her community, and raised more than $10,000 — half of that in small donations of a few dollars each. Towlerton explained, “My parents instilled a desire to give back, whatever your resources. Over my four years here, I’ve been able to contribute more than $15,000 to Fred Hutch, and I’m just one person!” Photo courtesy of Andrea Towlerton

11 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT DR. ERIC HOLLAND’S VISION TO TRANSFORM HOW SOLID TUMORS ARE TREATED

Dr. Eric Holland is bringing together researchers, data and big ideas to revolutionize treatment for patients with solid-tumor cancers. Photo by Bo Jungmayer / Fred Hutch

Big ideas and Big Data promise big improvements for patients

By Linda Dahlstrom and Deborah Bach where over 13 years he built a renowned brain cancer program, to come to Fred Hutch, which is known for pioneering treatments. Dr. Eric Holland aims to do something that hasn’t happened in His bold vision? Revolutionize how solid tumors in nearly a more than a half century: Find a better strategy for treating the dozen organs are treated. deadliest brain tumors. Shortly after arriving at Fred Hutch, Holland’s team launched Holland specializes in glioblastoma, a brain cancer that the Solid Tumor Translational Research (STTR) effort, which spreads quickly and is notorious for its ability to weave inside brings together investigators and clinicians from Fred Hutch, UW brain tissue. That makes it almost impossible for surgeons Medicine and Seattle Cancer Care Alliance. STTR is focused on to completely remove the tumors, called gliomas. The best developing precision treatments for tumors that include those available treatment — an aggressive combination of surgery, affecting the bladder, brain, breast, colon, head and neck, lung, chemotherapy and radiation — can cause brain damage, yet the ovary, pancreas and prostate. tumors almost always come back within months. One of the keys for achieving his vision is to build a first-of-its- Holland has dedicated his career to finding more effective kind database that researchers and clinicians can use to extract therapies with fewer side effects. Last year, he and 11 members of meaningful, potentially lifesaving, information from reams of his team left Memorial Sloan Kettering Cancer Center in New York, raw data on patients and their diseases. “No one has ever done

12 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > what we are doing,” said Holland, who directs the Hutch’s Human what if instead of administering radiation at uniform intervals Biology Division and the Nancy and Buster Alvord Brain Tumor where cycling cells were always at the same point each time, a Center at the University of Washington. staggered schedule was used to radiate cells when they were He’s starting with the brain. At MSK, he created the world’s most vulnerable? If researchers like Holland can figure out the most comprehensive brain tumor database. Based on tumor formula of how and when that’s happening, radiation could be samples from hundreds of patients, the database contains a timed to increase the chances of killing every cancer cell. Holland complete genetic profile of each tumor, plus details on how each has already shown staggered radiation can extend the lifespan of patient was treated and how they responded. Now Holland is mice with glioblastomas. building a similar These kinds database using of findings several thousand energize tissue samples Holland. The collected thing he by UW’s enjoys most Department of about being a Neurological scientist, he Surgery. said, is “looking The goal is for the truth — for every new and sometimes patient’s tumor finding it.” to be profiled. The truth Doctors can then of what he’s compare that learning in the profile to other lab — and the tumors in the information database and the tumor select the most database will effective therapy. Desert Horse-Grant (left) directs strategy and operations for the Solid Tumor Translational Research network. provide — are “This is She’s one of 11 team members who came with Holland from New York to develop new tumor therapies. Photo just beginning to by Robert Hood / Fred Hutch personalized redefine how he, medicine — and many other making decisions that are tailored to the tumor,” said Holland, physicians around the world, treat their cancer patients. who also is a practicing brain surgeon and a UW professor of “I love surgery — operating on someone lets you directly neurological surgery. improve their life,” Holland said, “and I love research because it’s a In addition to using Big Data to start transforming how chance to have an impact on many, many more people.” tumors are treated, Holland is investigating ways to make current treatments more effective by better understanding tumors. Many glioblastoma patients are treated with radiation after INNOVATIVE SOLID TUMOR TRANSLATIONAL RESEARCH, surgery, but recently researchers realized that some cells in an LIKE THAT BEING LED BY DR. ERIC HOLLAND, IS immature state (similar to stem cells) are resistant. What’s more, ACCELERATED BY GENEROUS SUPPORT FROM INDIVIDUAL the cancer cells can toggle between being mature and immature; BENEFACTORS, INCLUDING ELDON “BUD” MOUNT. imagine water sloshing back and forth, Holland explains. But

13 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT STUDY REVEALS VALUE OF LANDMARK WHI FINDING

Drs. Garnet Anderson (left) and Joshua Roth of Fred Hutch’s Public Health Sciences Division share findings with WHI participant and Hutch supporter Jean Rolfe regarding the thousands of lives and billions of dollars saved by a landmark combined hormone therapy study. Photo by Bo Jungmayer / Fred Hutch

Public investment and personal involvement in prevention research produce lifesaving dividends

By Diane Mapes bandied about for decades. But a newly published Fred Hutch study has gone far to lay that discussion to rest. The Women’s Health Initiative, launched in 1993, is one of the Dr. Joshua Roth, a postdoctoral fellow in the Hutchinson largest and most ambitious prevention studies ever conducted in Institute for Cancer Outcomes Research (HICOR), analyzed the U.S. the return on investment of just a portion of the WHI’s work, Designed to address research inequities and provide strategies the landmark finding that combined hormone therapy, or to thwart heart disease, breast and colorectal cancer, and other CHT, significantly raised a woman’s chance of developing leading causes of death and disability in older women, the WHI cardiovascular disease, stroke and breast cancer. has gathered health information from 161,000-plus post- “The economic return from the trial is substantial,” Roth said menopausal women for nearly a quarter of a century. That wealth when announcing his results in May. “The original NIH trial cost of data has been systematically managed and analyzed at Fred was $260 million (in 2012 dollars) and the net economic return Hutch, the WHI’s Clinical Coordinating Center, so researchers can was $37.1 billion. That’s a return of approximately $140 on every glean from it crucial, lifesaving insights. dollar invested in the trial.” Powered by an initial $625 million grant from the National Roth, who used a mathematical model to estimate the Institutes of Health, the WHI has tackled everything from the influence of a “no WHI world,” showed the CHT finding also directly health effects of hormone therapy and diet to life and longevity led to 126,000 fewer breast cancer cases, 76,000 fewer cases after cancer. of heart disease and stroke and 80,000 fewer cases of venous Given its expense, the WHI’s perceived worth has also been thromboembolism between 2003 and 2012.

14 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > “It really brings the point home when you crunch the numbers,” introduce Hutch science to the community, said her involvement he said. “You see that millions of U.S. women likely stopped gave her a unique perspective on cancer prevention research. or never used CHT and that this change resulted in important “Not everybody understands public health so doing something reductions in disease incidence and associated medical within the (Public Health Sciences) division better enabled me to spending.” speak to (that),” she said. Former Fred Hutch board member Jean Rolfe is one of the Dr. Garnet Anderson, principal investigator for WHI’s Clinical thousands of women who not only participated in WHI’s work Coordinating Center and director of the Hutch’s Public Health but, along with her three daughters, stood to benefit from it. Sciences Division, emphasized the incredible value of the The longtime civic leader said Roth’s study brings a new and contributions made by Rolfe and other participants. necessary perspective to the WHI’s findings. “That data has been used extensively,” Anderson told Rolfe. “This really substantiates what the research accomplished,” “We have probably published over 1,000 papers using data that she said. you’ve contributed to.” Although Rolfe was not part of the CHT investigation, for five Anderson also hailed Roth’s study for highlighting WHI’s impact years she provided WHI researchers with vital health data for both in terms of saving money and human lives. another study arm. “This is what prevention studies can do and we’re trying to Her involvement was just part of a pattern of public health get that word out,” she said. “These findings underscore the service that started when she was a young girl. significant role clinical trials play in science and the importance “My mother was a very big volunteer at (Seattle) Children’s, of continuing to find ways to strategically invest public research and I would go with her during the summer and that whetted my funds to maximize value to society. It’s brought a new perspective appetite,” she said. “My husband said I’d been practicing without a to think about it as an investment.” license for a very long time.” Rolfe’s long-standing relationship with Fred Hutch began in the 1980s and has included stints as board and senior council member, public speaker, donor and Board of Ambassadors co-chair. “They would report findings to us as board members and I always felt a great sense of accomplishment that I had something to do with it,” she said of her WHI participation. “It really appealed to me because it was women my children’s age and my age and above.” Rolfe, who currently champions Fred Hutch Longtime civic leader and former Fred Hutch board member Jean Rolfe is also a WHI participant. “I always felt a great by emceeing events that sense of accomplishment that I had something to do with it,” she said. Photo by Bo Jungmayer / Fred Hutch

15 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT ‘PERFECT PLACE’ FOR INNOVATION

A tiny liquid droplet, magnified under a microscope, glowing green to indicate that it contains a T-cell gene. Drs. Jason Bielas and Harlan Robins first developed QuanTILfy using this droplet-based technology to count unique T-cell DNA molecules. Photo courtesy of the Bielas and Ghajar Labs

Shared ideas lead to new test for cancer prognosis

By Susan Keown decisions. For example, a patient found to have fewer TILs (meaning a less favorable prognosis) might choose to start more Last year, a diverse group of collaborators at Fred Hutch aggressive treatments first, which could help prolong the patient’s demonstrated a new and powerful assay for predicting patients’ life. outcomes after cancer. QuanTILfy leverages a technology co-created by team member Their assay, named QuanTILfy, counts and sorts cancer- Dr. Harlan Robins, a computational biologist and associate fighting immune cells called tumor-infiltrating lymphocytes. member of the Public Health Sciences and Human Biology Patients with greater numbers of TILs tend to survive longer after Divisions at Fred Hutch. Robins’ powerful genetic technology can diagnosis; however, there has never been a way to reliably and map the unique surface markers of this diverse class of cells, consistently measure TILs — until now. which are otherwise difficult to characterize. The QuanTILfy team “What [our research] shows is that for the first time, you can formed after Bielas heard Robins speak about his technology and actually count the number of T cells that infiltrate into a tumor, the two began to seek a way to apply it to tumors. reproducibly. That hasn’t been done before,” said Dr. Jason Bielas, “We were in the perfect place,” Bielas said about their associate member of the Public Health Sciences and Human Fred Hutch–based team. “I think this is a very collaborative Biology Divisions at Fred Hutch. Bielas, a cancer geneticist, led the environment: Ideas are shared even before they’re published, team that developed and tested this method for the first time, in just when they’re beginning.” Sharing research in its early stages ovarian cancer. provides scientists from different fields with opportunities to Now a valuable research tool, QuanTILfy has the potential collaborate, Bielas said, which can open doors to new lines of to become a standardized clinical test for guiding treatment inquiry that might otherwise go unexplored or lead to new insights

16 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > more quickly by bringing fresh perspectives to challenging Adaptive has significantly upgraded QuanTILfy’s methodology problems. and is leading further testing with the goal of launching a clinical Now that QuanTILfy has proven its potential, researchers at version by 2015. Thanks to this unique partnership, built in the Fred Hutch and at biomedical companies are using it in studies hallways and labs of Fred Hutch, we are seeing the birth of a tool of TILs in many types of solid tumors, from melanoma to lung that could soon help doctors and their patients make the most cancer. What they learn could offer an unprecedented view of effective treatment choices. the interactions between the immune system and tumors. This knowledge will help scientists design new therapeutic strategies — for example, strengthening an existing immune reaction or SUPPORT FROM CHUCK GOGGIO AND OTHER removing a tumor’s protective barriers — that capitalize on each MEMBERS OF THE PRESIDENT’S CIRCLE FUELS THE patient’s unique situation. WORK OF FRED HUTCH SCIENTISTS TO DEVELOP Adaptive Biotechnologies, a firm co-founded by Robins and two GROUNDBREAKING NEW TOOLS FOR CANCER Fred Hutch colleagues, holds the license for both QuanTILfy and RESEARCH AND TREATMENT, LIKE QUANTILFY. its underlying genetic sequencing technology. Within the last year,

Drs. Jason Bielas (left) and Harlan Robins (right) collaborated on a new tool for predicting prognosis in cancer patients. Photo by Bo Jungmayer / Fred Hutch

17 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT NEIGHBORS REACH OUT TO HELP CHILDREN A WORLD AWAY

Naheni Teopista played with her 6-year-old granddaughter, Naula Kamondi, who was feeling better after starting treatment for Burkitt lymphoma. Naula’s care was provided through a joint Fred Hutch-Uganda Cancer Institute research project funded in part by Lisa Martin and Ken Fabert. Photo by Robert Hood / Fred Hutch

Benefactors Lisa Martin and Ken Fabert help launch research program to cure children with cancer in Uganda

By Dr. Rachel Tompa lymphoma patients, but the next time he visited it became clear the funds had not gone far enough. How could they? The facility When Fred Hutch’s Dr. Corey Casper first visited the Uganda had limited pain medications, running water and electricity. There Cancer Institute (UCI) in Kampala, Uganda, he was disturbed by was only one oncologist to serve the entire country. the arresting sight of children with the most common pediatric cancer in Uganda, Burkitt lymphoma. The disease, triggered by the Epstein-Barr virus, causes fast-growing and disfiguring tumors, usually on the jaw. An expert in infection-related cancers, Casper understood all too well the senseless tragedy of what he saw. Burkitt lymphoma is highly curable — in the U.S., a simple chemotherapy regimen cures up to 95 percent of kids with this disease. When Casper first visited Uganda’s sole cancer treatment facility in 2004, only an estimated 30 to 40 percent of Ugandan children with the cancer survived a year past diagnosis. And those were the ones who got treatment. Many do not have access to care. Dr. Corey Casper, head of Fred Hutch’s Program in Global Oncology, is working When he returned to the U.S., Casper and his family sent to find sustainable solutions for cancer patients in Uganda — and beyond. a personal donation to the UCI for chemotherapy for Burkitt Photo by Robert Hood / Fred Hutch

18 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > “I realized that unless we deal with this cancer holistically, to overcome all barriers Ugandan children with the disease face, there’s no point,” said Casper, who also heads Fred Hutch’s from awareness and diagnosis to completed treatment. The Program in Global Oncology. Burkitt Lymphoma Project topples these barriers by purchasing Casper and his Fred Hutch colleagues built a partnership with chemotherapy during shortages in government-supplied drugs, the UCI to start tackling the problem at its roots. Through the reimbursing families for transportation to and from the UCI, UCI/Hutchinson Center Cancer Alliance, they laid the groundwork creating an electronic tracking system, supplying daily meals to for improving cancer research and care, from bringing Ugandan patients, and pairing families with case managers for one-on-one doctors to Seattle for cutting-edge oncology training to ensuring assistance. UCI nurses had enough latex gloves to administer chemotherapy. Since it began enrolling patients in 2012, the Burkitt And they began planning a program to treat every Burkitt Lymphoma Project has seen 125 children with the disease. The lymphoma patient at the UCI. team is already documenting Later, a fortuitous chance incredible changes (see story drew Casper together with below), all of which are adding benefactors Lisa Martin and Ken up for their patients. Now, more Fabert, himself a practicing family than 60 percent of these kids physician. The couple already survive for a year or more past supported Fred Hutch research, treatment, almost double the but when Erica Sessle, at the survival rate before the Fred time the managing director of the Hutch program began. UCI/ Hutchinson Center Cancer Dr. Innocent Mutyaba is one Alliance, moved in next door to of the Ugandan doctors who Martin and Fabert, neighborly trained in oncology at Fred small talk led to the next step in Hutch. Now he coordinates their giving. the Burkitt Lymphoma Project “It was literally an over the on site in Kampala, and he’s backyard fence kind of thing,” pleased with their progress. Fabert said. “We had a few social “For Burkitt, we have chats about [Sessle’s work]. We fantastic success stories,” said, ‘How’s it funded, how’s it Mutyaba said. structured, what are you doing?’ Lisa Martin and Ken Fabert have been pleased with the progress of the To cure even more children, and one thing led to another.” Burkitt Lymphoma Project, which their contributions helped to launch. the team is working with Photo by Bo Jungmayer / Fred Hutch Through Sessle, they met Ugandan dental providers Casper and others on the Fred to refer suspected cases Hutch team. The more they learned, the more intrigued they earlier, since dental problems are common early signs of Burkitt became. lymphoma. And they are improving diagnostic techniques, eagerly “There’s a mantra in philanthropy: As much or more than anticipating the on-site pathology lab that will be part of a new institutions or organizations, you fund people,” Fabert said. Martin Fred Hutch/UCI facility slated to open early in 2015. added, “There are a lot of good people there!” They’ve also set a track record to be emulated. UCI clinicians Through their family foundation, the couple made a three- treating patients with Wilms tumor, a pediatric kidney cancer, year pledge to support the team’s work. Their gift in combination are now implementing some of the tools the Burkitt Lymphoma with funding from the Burkitt Lymphoma Fund for Africa and the Project put in place, including case managers, electronic medical National Cancer Institute launched the Burkitt Lymphoma Project. records and transportation reimbursement. Private support is integral to the researchers’ comprehensive Martin and Fabert have been pleased to see the immediate approach, Casper said. Most grants he could apply for were effect their support has had in Uganda and how far their dollars restricted to research, but first and foremost, the children needed have gone to save lives there. treatment — treatment this funding allowed them to provide. “The amounts of money that our grant covered aren’t huge Although UCI researchers established combination amounts,” Fabert said. “It’s nice to think that there are niches … chemotherapy’s power to cure Burkitt lymphoma nearly 50 years where relatively modest grants can potentially have a significant ago, Casper’s team needed to show the power of their system impact.”

19 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > On a visit to the Uganda Cancer Institute, Ronald Lumala cuddled his 4-year-old son, Mike Kiragga, who was successfully treated for Burkitt lymphoma. Photo by Robert Hood / Fred Hutch

A father’s greatest gift: His son’s life

By Mary Engel Kampala. Eventually that hospital, after doing a biopsy, sent him to the UCI. Looking at the bright-eyed boy sitting on his father’s lap at There he met Susan Nabakooza, a UCI nurse who also the Uganda Cancer Institute, it’s hard to believe that 4-year- works as a case manager for the Burkitt Lymphoma Project, old Mike Kiragga once had a tumor on his jaw so huge he a joint initiative of Fred Hutch and the UCI. Kiragga was couldn’t turn his head. admitted to the UCI and treated for his fever and pain. Once Kiragga had Burkitt lymphoma, one of the fastest growing the diagnosis was confirmed, he was immediately started on cancers and the leading cause of cancer deaths in children in chemotherapy. sub-Saharan Africa — but one that is highly curable if treated It was Feb. 13, 2013. Virtually overnight, the tumor shrank in time with chemotherapy. by almost half. But his father, Ronald Lumala, a farmer from a small village Kiragga spent two weeks as an inpatient at the UCI. After in west-central Uganda, originally had his own explanation for his second dose of chemotherapy, the tumor shrank yet again. the mysterious swelling that appeared in December 2012: He He was discharged and his father was told to return every two feared Kiragga had been bewitched. weeks until the full regimen of six treatments was completed. How else to explain a lump that kept growing and growing? Kiragga completed his cancer therapy in May 2013, and he No one in his village had seen anything like it, and his continues to come into the UCI for follow-ups. There is no sign neighbors agreed that witchcraft was involved. of the cancer. Lumala took his son to traditional healers, trading goats “He never believed he would have that child back,” said for care. Nothing helped. So he tried his village medical clinic, Nabakooza. “Now every time he sees the child, he’s just so which referred him to Mulago Hospital, the nation’s largest, in happy.”

20 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT BRINGING OTHERS ALONG FOR THE RIDE TO END CANCER

Members of Team Society crossing the finish line in 2014. From L to R: Sim Rubenstein, Pete Kosowski, Hayley Duitch and Steve Burns. Photo by Lisi Wolf Photography

Obliteride participant’s enthusiasm for Fred Hutch research inspires others to get involved

By Susan Keown Her first Obliteride finish, however, didn’t come easy. While riding with a painful knee injury sustained during her training, it Hayley Duitch is proof that passion can have an outsized was the thought of the many people she knows with the disease impact on advancing cancer research. that kept her going. “I want to be part of finding a cure,” said Duitch, who has “That 50 miles was nothing compared to what they were going watched many friends and family members struggle with cancer. through,” Duitch said. “Each stroke, I’d just say their names over Through fundraising, Duitch has forged a partnership with Fred and over and over again, just to get through it.” Hutch that allows her to kick-start progress, even from outside After such a difficult experience, some people would throw the labs and clinics of cancer research. in the towel. But this year, Duitch rode again — and brought her “I’m not a scientist,” she said. “I’m just a normal person that entire company along. doesn’t want anyone to have to go through it.” “Our response was, ‘Yes, how do we start?’” said Josiah In 2013, Duitch, a resident of Mercer Island, Washington, and Johnson, co-founder and vice president of Society Consulting, a business consultant, joined a small team of family and close Duitch’s employer, recalling Duitch’s first conversation with friends to ride in the inaugural Obliteride in memory of a family company leadership about Obliteride. friend who died of brain cancer in 2010. Duitch was drawn to the Her pitch struck a chord with both Johnson and John Bergen, fact that all proceeds from Obliteride, an annual bike ride through another cofounder and the president of Society Consulting. the Puget Sound region, support cancer research at Fred Hutch. Obliteride offered a way for their company to combine two

21 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CONTINUED NEXT PAGE > Duitch’s 2013 bike, covered with the names of people with cancer submitted by her supporters. As inspiration during her tough ride, Duitch repeated these names as a mantra. Photo courtesy of Hayley Duitch important interests: support of local charitable causes and cycling — several staff members are dedicated cyclists and the company sponsors a competitive road and cyclocross racing team. “On every level, from the DNA of our culture, to the values of what Obliteride stood for — with this world-class research organization right here in our community — it really just touched on everything that we stand for,” Bergen said. Society Consulting decided not just to form a team around co-captains Duitch and Johnson to fundraise and ride in the event, but to become an Obliteride sponsor as well. Even with encouragement from the top, Duitch had to work to persuade some of her new colleagues to join the ride. She sent company-wide emails to rebut excuses she’d heard, from not having a bike (her reply: “We can find you one to borrow”) to the ride being hard (Duitch’s response: “My 14-year-old nephew did it”). She stopped to talk to her coworkers in the halls. Team Yo Adrienne, Duitch’s 2013 Obliteride team. Photo courtesy of Hayley Duitch. Duitch laughs about her enthusiasm for recruiting new members to Team Society. “I don’t want to force people to do it,” But this year, thanks to her ability to inspire others to get involved, Duitch said with a grin, “but I definitely think, at a very minimum, more than ten times that was raised, including over $10,000 25 miles isn’t that hard.” in pledges that Bergen raised through his participation in Ride Duitch’s persuasion paid off. On August 10, 2014, Team Society Across America, a cross-country bicycling race. had 25 riders, one volunteer and one virtual rider, including all the Duitch doesn’t have a medical degree. Neither does she members of Duitch’s 2013 team. have a Ph.D. But what she does have is a contagious passion. In Last year, Duitch gathered almost $3,000 in donations for Fred partnership with an organization that channels passion into cures, Hutch research as an Obliteride rider — no small feat on its own. that’s all it takes.

22 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT MESSAGE FROM PAULA REYNOLDS BOARD OF TRUSTEES CHAIR, FISCAL YEAR 2014

Photo by Robert Hood / Fred Hutch

Seeing Fred Hutch breakthroughs translate into lives saved

CURES START HERE. day in the real world. In the last year, over well as exceeded all previous records for That’s the theme of this year’s report 7,000 patients were treated at Seattle donations. and it succinctly captures the story of our Cancer Care Alliance (SCCA), our affiliated In May, the Board accepted the center. Fred Hutch has historically had a clinical branch where we join forces with resignation of Fred Hutch’s president and reputation as the world leader in curing Seattle Children’s and UW Medicine. At director, Dr. Larry Corey, which took effect blood-borne cancers. But this remarkable SCCA, we translate our world-class science June 30, the end of our fiscal year. We are accomplishment is only part of the story. into patient care. SCCA treats more cancer grateful for all that Dr. Corey accomplished Our scientists conduct research that cases than any other medical center in the in his tenure. The Board is conducting an relates to a wide spectrum of cancers — region and is the place where patients with international search for a successor and and a host of other diseases, too. rare, complex and advanced cancers gain expects to announce a selection shortly. In this last year alone, our scientists hope through novel therapies. Meanwhile, we appreciate the leadership of have made dozens of scientific In the past year, Fred Hutch has faced our deputy directors, Dr. Mark Groudine and breakthroughs. Most widely covered in the a number of challenges, the greatest of Dr. Fred Appelbaum, during this transition. media has been our work in the area of which has been reduced funding from our It is an honor to serve as the Chair of the immunotherapy, which is among the most largest supporters, the National Institutes Board of Trustees. My fellow trustees have exciting developments in the search for of Health. Your Board of Trustees has shown singular dedication to Fred Hutch. In cancer cures. But as you read this annual embarked on a strategy to diversify our return, we are privileged to associate with report, you can learn more about the funding sources and ensure our success extraordinary scientists. We see firsthand myriad discoveries being made by Hutch far into the future. Meanwhile, we have how their breakthroughs translate into scientists. been heartened by the generosity of our saving lives. We are grateful to them for Fred Hutch, however, is not just a donors. In this last fiscal year, Fred Hutch their unwavering commitment to lives of research institution. Our scientist- received the largest gift in our history — a science — and to you, our benefactors, for physicians apply research findings every $20 million gift from the Bezos family — as your continued and generous support.

23 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT CURES START HERE

PRIVATE CONTRIBUTORS FISCAL YEAR 2014 Fred Hutchinson Cancer Research Center relies on private contributions to accelerate scientific advances. This crucial support aids in the pursuit of novel ideas, sustains promising research and enables scientists to explore new directions as they emerge; all paramount in the fight against cancer and related diseases. We thank each of the 31,202 benefactors who provided $44,089,301 million in contributions, pledges and in-kind gifts between July 1, 2013 and June 30, 2014. Each of the individuals, corporations, foundations and organizations listed below contributed or pledged $1,000 or more within the 2014 fiscal year. We are grateful for the generous investment from all of our supporters in our relentless pursuit to improve the prevention, detection and treatment of cancer and related diseases.

Nobel Laureates Circle Bill and Melinda Gates The Seattle Foundation Cliff and Virginia Fiscus The Nobel Laureates Circle recognizes Bob and Eileen Gilman Family Sheldon Manufacturing, Inc. David and Patricia Giuliani and Foundation benefactors who have made cumulative David and Patricia Giuliani and Foundation Frank and Harriet Shrontz Jeff and Julie Guillot gifts of $1 million or more. These key The GM Foundation The Sloan Foundation The Hope Foundation contributors are permanent members of Calvin A. Gorman Trust St. Baldrick’s Foundation Hyundai Hope on Wheels the Circle which was established to honor Alice Coulon Hanson Susan G. Komen for the Cure Nelda Kleinschmidt Estate Fred Hutch’s Nobel Prize recipients, Drs. John J. and Katherine A. Harnish Herman E. Tenzler Estate The Lustgarten Foundation E. Donnall Thomas (1990), Lee Hartwell Lee Hartwell and Theresa Naujack Hartwell Dr. and Mrs. E. Donnall Thomas Prostate Cancer Foundation (2001) and Linda Buck (2004). By giving at The Hearst Foundations Mikal and Lynn Thomsen The Seattle Foundation this level, members of the Nobel Laureates The Helen Hay Whitney Foundation Hazel Johnson Toly Estate Susan G. Komen Circle are at the forefront of philanthropic Bob and Pat Herbold Bonnie and Jim Towne United Way of King County leadership and make a significant impact Arthur P. Holm Estate Turner Construction Company Paul S. Warber Estate on Fred Hutch’s mission to eliminate Howard Hughes Medical Institute United Way of King County Elizabeth Wayner cancer and related diseases as causes of Yvonne Twining Humber Estate W. M. Keck Foundation James and Beverly Weiss Trust human suffering and death. Immunex Paul S. Warber Estate J. Orin Edson Foundation Elizabeth Wayner $100,000 - $249,999 Madeline and Howell E. Adams, Jr. Jacob Green Charity Golf Classic Richard W. Weiland Estate Jeff and MacKenzie Bezos Mr. Paul G. Allen Erna M. Jorgensen Trust The Breast Cancer Research Foundation American Cancer Society José Carreras International Nobel Laureates Circle membership Centre hospitalier universitaire vaudois American Heart Association Leukemia Foundation includes seven anonymous benefactors Collaborative Ependymoma Research Amgen Nelda Kleinschmidt Network (CERN) Foundation The Anderson Foundation Leukemia & Lymphoma Society Costco Wholesale Robert M. Arnold Life Sciences Discovery Fund Fiscal Year 2014 Benefactors CRP-Santé Avon Foundation for Women Listwin Family Foundation Clairmont L. and Evelyn S. Egtvedt Bezos family LIVESTRONG $1,000,000 and Up H. Canan Ehnes Estate Bill & Melinda Gates Foundation Lymphoma Research Foundation American Cancer Society Ellison Foundation Burroughs Wellcome Fund Lucille P. Markey Charitable Trust Robert M. Arnold The Ellison Medical Foundation Canary Foundation Mr. John A. McCone and Bezos family Elsa U. Pardee Foundation Cancer Research Institute Mrs. Theiline Pigott McCone Bill & Melinda Gates Foundation John and Christine Enslein Cell Therapeutics, Inc. Paul Edwin Melcher Estate Charles E. Stuart Charitable Foundation Friends of FSH Research Charles E. Stuart Charitable Foundation Microsoft Ed and Karen Fritzky Family Mylo and Marion Charlston Moneytree, Inc. $500,000 - $999,999 The G. Harold & Leila Y. Mathers Foundation Costco Wholesale John and Susie Morganti Estate Damon Runyon Cancer Giles W. and Elise G. Mead Foundation Mr. and Mrs. Fenwick J. Crane The Moyer Foundation Research Foundation Rochelle Greenberg Roger and Gloria Crouch Craig and Marie Mundie Foundation for the National George and Linda Guillot Damon Runyon Cancer Research M. J. Murdock Charitable Trust Institutes of Health Howard Hughes Medical Institute Foundation Muscular Dystrophy Association Leukemia & Lymphoma Society Imperial College London Delta Tau Delta Fraternity The Norcliffe Foundation LIVESTRONG Foundation Inserra Family Foundation Peter S. and Sandra W. Dyer Carol-Ann O’Mack and John Deininger Frank Shrontz International Vaccine Institute J. Orin and Charlene Edson Dorothy and Everett O’Neill The Sloan Foundation J. Orin Edson Foundation Clairmont L. and Evelyn S. Egtvedt The Paul G. Allen Family Foundation St. Baldrick’s Foundation Jacob Green Charity Golf Classic The Ellison Medical Foundation James B. Pendleton Charitable Trust The John C. and Karyl Kay Entertainment Industry Foundation / Prostate Cancer Foundation $250,000 - $499,999 Hughes Foundation Women’s Cancer Research Fund James and Sherry Raisbeck Alex’s Lemonade Stand David Jones and Maryanne Tagney The Eucalyptus Foundation Richard C. Goldstein Private Foundation Foundation for Childhood Cancer Brian Michael Jones and Anna E. Rodzinski Fannie E. Rippel Foundation Jim Roberts and Pam Becker Mildred R. Brown Trust Erna M. Jorgensen Trust Friends of José Carreras International Dorlesca Hazel Ryan Estate The Caladan Foundation Rae and Mark Lembersky Leukemia Foundation Safeway Inc. Comcast Earl G. Lewis Estate David Worthington Garner Trust James G. Scripps Estate The Eucalyptus Foundation Life Sciences Research Foundation

24 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Laurie D. Lima Trust The Jane Coffin Childs Memorial Fund for Employees Community Fund of Ric and Kaylene Anderson Lupus Research Institute Medical Research The Boeing Company Mr. and Mrs. Stephen L. Anderson Barbara F. Meehan Estate Mike and Diane Johansson F5 Networks, Inc. Mr. and Mrs. Eric J. Andrews The Moyer Foundation Kalmanovitz Charitable Foundation John and Rosemary Fedorochko Trust Dr. Frederick and Dita Appelbaum Multiple Myeloma Research Foundation KING Broadcasting Flaherty Living Trust Apptio Technology Business Management National Breast Cancer Foundation, Inc. The Lambeth Family Designated Fund Flight Options Athena Partners Foundation Gudrun D. Olsen Estate Laura A. Landro and Richard E. Salomon The Geiger Family Foundation athenahealth Carol-Ann O’Mack and John Deininger Lease Crutcher Lewis Roger and Cheryl Gelder Averro Ovarian Cancer Research Fund Lynn Lippert and Sal Jepson John H. Gelston, Jr. and Joe and Karyn Barer Robert and Rebecca Pohlad Rob and Teddy McGregor Wilhelmina L. Gelston Bill and Sara Barrett Premera Blue Cross Melanoma Research Alliance Bob and Eileen Gilman Family Mr. Sheldon Baskin Rakay Foundation Microsoft glassybaby Bayley Construction The Rona Jaffe Foundation Mo-dazz for the Arts Mark Groudine and Cynthia Putnam Ron and Joan Bayley Dorlesca Hazel Ryan Estate Muscular Dystrophy Association Donald Guthrie and Candace Tkachuck Sally Skinner Behnke Safeway Inc. Julie Niven Estate John J. and Katherine A. Harnish Barbara Berg and Dan Gottschling Sarah M. Hughes Foundation James B. Pendleton Charitable Trust Peter and Peggy Horvitz Charlie and Courtni Billow Rosalyn H. Schuknecht Estate Debra and Jay Platt ImpactAssets Bishop Family Legacy Foundation Searle Scholars Program Quest for Truth Foundation Infectious Diseases Society of America BK Invitational Golf Tournament Sinegal Family Foundation James and Sherry Raisbeck Jane C. Artz and Frederick J. Artz Fund Bruce McDonnell Memorial Golf Classic Ruth L. Truitt Estate Paula and Stephen Reynolds The John and Louise Steegstra Shari and Frederick Burns The V Foundation for Cancer Research Richard C. Goldstein Private Foundation Memorial Fund Canadian Institutes of Health Research Wissner-Slivka Foundation Milton B. Rubin Rich and Karmann Kaplan Carlson Family Foundation Joseph and Janet Zinn John and Nancy Rudolf Klingman Open The Catherine Mayer Foundation Seraphine J. Scanlon Estate Mike and Debbie Koss Charles B. See Foundation $50,000 - $99,999 Jim and Bet Schuler Mrs. Frederick Kullman Brad and Judy Chase 710 ESPN Seattle Schultz Family Foundation Benito and Carmen Lopez Chateau Retirement Communities American Sexually Transmitted Scleroderma Foundation Mark and Nikki Mahan Chihuly Studio Diseases Association Bill and Marlene Semple Martin-Fabert Foundation Children Count Foundation Amgen Jim and Jan Sinegal John and Liz McAdam Mr. Eric W. Christenson The Anderson Foundation Starbucks Matt and Carol McIlwain Gustav E. Churchill Estate Anduin Foundation Suskin Foundation Mrs. Charlotte H. Merritt Mike Clayville ASBMT Mrs. Dorothy E. Thomas Norman and Suzanne Metcalfe Coca-Cola Refreshments USA Inc AT&T Veronica Turvey Estate Michael’s Toyota of Bellevue Colleen’s Dream Foundation AT&T Foundation University Mechanical Contractors, Inc. Richard and Kathryn Miyauchi Drs. Steven and Kathy Collins The Aven Foundation Clinton Nelson Vipond Estate Multiple Myeloma Opportunities for Comerica Bank Bartell Drugs Bruce and Peggy Wanta Research & Education The Container Store David and Joanna Beitel Washington Research Foundation Murray Franklyn Group Jordan and Katie Corey Yahn Bernier and Beth McCaw Ann P. Wyckoff Robert E. and Amy T. Neiman Barbara Cosgrove and Frank Yandrasits Cathy Boshaw and Doug Edlund John and Billie O’Mack Steve and Julie Crantz Canary Foundation $25,000 - $49,999 Sujal and Meera Patel Michael and Judith Crutcher Conquer Cancer Foundation of the Alaska Airlines Prevent Cancer Foundation The CSM Foundation American Society of Clinical Oncology Betty J. Allsop Estate SASCO Foundation Arline G. Dahl Estate Jane and David Cottrell American Heart Association Savers, Inc. Andy Davis Crabby Beach Foundation amfAR Seattle Met Mark D. Davis Roger and Gloria Crouch Mrs. Dorothy E. Anderson Craig Shrontz and Lynn Ristig Dr. H. Joachim Deeg and Cuyamaca Foundation Aplastic Anemia & Phil and Sally Smart, Jr. Mrs. Francoise Deeg-Le Gal Delta Air Lines MDS International Foundation Spectrum Controls Helen S. Dent Estate Delta Tau Delta Fraternity Bayley Family Foundation Arthur and Lori Sullivan Laura and Jim DiLella Holly and Eric Dillon Carl and Renée Behnke Turner Construction Company Carey and John Dondero Dorsey & Whitney Trust Company LLC Nils Dean Berggren TVI, Inc. The Dr. Maxwell Hurston Family Foundation Janice J. Dulet Estate Yvonne M. Betson Trust - Mrs. Vilma F. Vojta Earl and Lois Dusenbery Entercom Seattle Jeff and Ethel Maxwell Dr. Lawrence G. Votta Echo Bay Foundation David Worthington Garner Trust Debbie and Jim Bevier Doug and Maggie Walker Karl and Carol Ege George and Margaret McLane Foundation James Boshaw Mr. Joseph N. Walter and Ms. Kathy L. Mares Ingrid W. Elliott and Joel A. Shapiro Mr. and Mrs. Warren A. and Inge M. Geri Elisabeth Bottler Wilson Construction Company The Employees Community Fund of Glaser Foundation Brain & Behavior Research Foundation Marcia Johnson Witter and Max Witter Boeing Puget Sound Virginia Green Trust Patricia L. Bryant Mr. and Mrs. Luis F. Esteban David and Susan Heckerman Gary and Catherine Bylund $10,000 - $24,999 Esterline Technologies Corporation The Helen Hay Whitney Foundation Clear Channel Entertainment Frank W. Akers Estate Expedia, Inc. Histogenetics Virginia Cosgrove Aisha Ahmad Al Khinji Limei Fan and Jay Na Hornall Anderson Design Works LLC Coxon Family Foundation Alana Dung Research Foundation The Fischer Family Fund of the The Dean Witter Foundation American Endowment Foundation Jewish Community Foundation

25 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Fortune Family Foundation Bill and Jane Lewis The Sheri and Les Biller Family Foundation Battery Ventures The Foster Foundation Liberty Mutual Albert Shum Bayer Mr. and Mrs. Michael G. Foster, Jr. Frank and Marianne Liebermann Mark and Brenda Simons Ben Bridge Jeweler Frank R. and Faye M. Zimmerman James Lintott and May Liang Dr. and Mrs. Robert M. Sinskey Bessemer Trust Family Foundation Lund Engineering Inc. and Family Doug Smith and Mary Templeman-Smith Mike and Jackie Bezos Mr. Robert Frey Julie and Erik Lund Sandra L. C. Smith Mr. Hans E. Bishop Gabrielle’s Angel Foundation for David and Nathan Mandelbaum Family Doug and Marilyn Southern Bill and Jeanne Bliss Cancer Research David Mann and Ann Thomson Mann Tom and Diane St. John John R. and Paula Blood Family Trust Mrs. E. Peter Garrett Mariners Care Starwood Hotels & Resorts Blue Danube Productions Michael and Lynn Garvey Mattaini Family Foundation Howard and Cynthia Steinberg Blue Nile, Inc. Aaron and Betty Gilman Family Kevin and Sarah McCain John and Sherry Stilin Botanical Designs Kari Glover and Thad Alston Mr. Tim R. McCulloch Dr. Rainer Storb and Mr. and Mrs. Freeman E. Boyer Jim and Gerry Godfrey - The Michael Miyauchi Foundation Dr. Beverly Torok-Storb Bristol-Myers Squibb Company Chateau Retirement Communities Michael Moritz and Harriet Heyman Ambassador Cynthia Stroum Steve and Jennifer Brooks Val and Ivene Goemaere Joan Morse and Dean Hachamovitch The Swanson Family Brush Dental Charles Goggio, Jr. Moss Adams LLP Gary and Diane Swofford Madelyn Bryant-McIntire and John McIntire Goldman, Sachs & Company Bud Mount Symetra Financial Karen and Bill Buchan The Grainger Foundation Shan and Lee Mullin Ms. Myra H. Tanita Mr. Aaron Bueler and Ms. Carolyn True Nancy Gudmundson M. J. Murdock Charitable Trust TIAA-CREF Fred and Joan Burnstead Erik and Susan Hansen Paul and Carol Neiman Titan Outdoor Mr. and Mrs. Jerry Bush John and Suzanne Hansen Robert Nelsen and Ellyn Hennecke Bonnie and Jim Towne butter LONDON Deborah and Eric Haug The Nick and Leslie Hanauer Foundation Jean L. Towne Trust Mrs. Cecelia C. Carr Hal and Jerry Haynes Charles and Eleanor Nolan Toyota of Puyallup Cedar Grove Compostables Marco J. Heidner Charitable Trust North Mason Cancer Crusaders Merna B. Trowbridge Trust CFC of the National Capital Area Jeffrey and Shelly Heier Northern Trust Tom and Margo Van Halm Charlie’s Produce Jon and Kim Hemingway Lee and Deborah Oatey Peter and Shannon van Oppen Kelly Cheeseman HHV-6 Foundation Pam Oyanagi and Dwayne Myers Van Sloun Foundation Mr. John P. Chilcote Mike and Judi Hickey The Paul M. Anderson Foundation Jean Baur Viereck Mr. Rajesh Chopra and Ms. Tracy McNally Pete and Leslie Magid Higgins Harry Jonathan Pearce Farid and Asha Virani Robert Christiansen Iva and Lawrence Hirsch Perkins Coie LLP Vs. Cancer Foundation Richard and Jane Christie Jerick R. Hoffer Pete and Wilma Olsen Foundation Tom and Jeanne Walker City of Seattle Dr. and Mrs. Eric C. Holland Tom and Kate Peters Pamela Wallenberg-Madigan and Clif Bar, Inc. Frank and Lisa Holland Dean and Josephine Petterson Frank Madigan Clovis Foundation Desert Horse-Grant John B. Piacentini Family Drs. Edus and Linda Warren Helen Zehnder Cole Memorial Mr. Bradley J. Horwitz Paul and Beth Picardo Bryan and Pamela Weeks Taryn D. Coles Mr. Norman E. Hubbard Plum Creek Timber Company, Inc. Weinstein Family Foundation Dr. Jonathan Cooper and Diane Doles The Ildhuso Family PODS Enterprises, Inc. Nancy Weintraub Copiers Northwest, Inc. Nea Lynn Ireland Dean and Gwenn Polik and Valerie Polack Alice Marcella Williams Trust Corliss Estates Winery David M. and Amanda K. Jackson Florence J. Wiggen Potter Estate Winebow, Inc. Tim Cosgrove Christina Jallings Precision Electric Group Woldenberg Foundation Mr. and Mrs. Garland D. Cox Henry and Mary Ann James Presage Biosciences The Yeck Family Larry and Vickie Culver The Jean E. Thomson Foundation Tim and Kathy Proctor Melinda M. Yount Dr. Thomas O. Daniel Andy Johnson-Laird and Kay Kitagawa Ms. Elizabeth H. Purcell ZGF Architects LLP Datec Inc Mr. and Mrs. Tim C. Jones RACE Charities Foundation Zillow Kurt and Suzan DelBene J.P. Morgan James V. Ramsdell, Jr. Delta Dental of Washington Kaye-Smith Andrew and Christine Reinland $5,000 - $9,999 Mr. and Mrs. Bruce D. Douglass Nancy N. Keefe Estate Lee Rhodes and Peter Seligmann Francine Horn Abrams Dr. and Mrs. Jonathan G. Drachman Keith & Mary Kay McCaw Family Foundation Ron and Katie Robertson Academy Of Nutrition And Dietetics Elysian Brewing Company Kenneth and Dorothy L. Anderson Robinett Family Alexandria Real Estate Equities, Inc. David and Sharon Eskenazi Family Foundation Elizabeth W. Robinson and Allstate Giving Campaign Expeditors International of Keyes Foundation John McVickar Robinson Chap and Eve Alvord Washington, Inc. Kibble & Prentice, A USI Company Mr. Tom Robinson and Ms. Carla Murray Amangiri Canyon Resort Adam and Shannon Fain Jonathan and Pamela Kil Donald C. Rockser Trust Ameriprise Financial Employee Barbara Feasey and Bill Bryant King County Combined Federal Campaign Judith and Kermit Rosen Giving Campaign Firstgiving, Inc. Kinzer Real Estate Services William H. Rubidge Estate Ron and Kimberly Andronaco Jens Fischer and Susanne Wagner-Fischer Reg and Ann Koehler Rural Metro Kathleen Arneil Phelps and Christel Fisher Harry Korrell Ms. Stephanie Saelee and Mr. Oltion Hyseni Bill and Pam Ayer Mr. and Mrs. Brian C. Flynn, Jr. Ronnie Elizabeth Krejce Estate Mr. and Mrs. Michael Sandorffy Mr. Ronald R. Bailey Cay Fortune and John Shimer CAPT M. Thomas & Mrs. Gwenann Kroon Satya and Rao Remala Foundation Mary M. Baker Foster Pepper Jason M. Kuhn Charles and Mary Ann Schroeter Bank of America Stephanie and Harold Fowler Kyoko Kurosawa and Steve Pergam, M.D. Seattle Genetics, Inc. Donald and Maxine Barnard Fraternal Order of Eagles #1722, Sandra L. La Haye Sheraton Seattle Hotel Peter and Jane Barrett Renton Auxiliary

26 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Mr. and Mrs. Burke F. Gibson Patti and Gene Neuberger Dr. Barry L. and Amy B. Stoddard Jerry and Rita Anches Tim and Jennifer Goggin Christopher and Kathleen Nielsen Stoel Rives LLP Carlene F. Anderson Mr. Stone Gossard Nutricia North America, Inc. The Thomas R. and Deborah A. Davidson Charles Anderson and Pamela Gross Mrs. Ingrid Graham Roger F. Nyhus Foundation Connie and Lee Anderson Mr. Stephen M. Graham and Dr. James P. O’Brien and Dr. Shirley O’Brien Mr. Teddy R. Thomas Mr. and Mrs. Jack Anderson Mrs. Joanne M. Graham Dr. and Mrs. James Olson Tides Mr. and Mrs. John N. Anderson Grand Chapter of Washington - Open Square Paul, Pat and Siri Tift Mrs. Karen C. Anderson Order of the Eastern Star Orswell Events, LLC Bradley and Danielle Tilden Dr. and Mrs. Kenneth N. Anderson, Sr. Leonard and Joni Green Orthopedic Physician Association Brett and Suzanne Tocco Scott D. Anderson Guy Carpenter & Co., LLC Colonel Clyde W. Owen Mr. Christopher Toher Travis Gregory Anderson and Sandra Hanson Trust Pacific Wine & Spirits of Washington Annette Toutonghi and Bruce Oberg Kendra Gurnett Mr. and Mrs. Joe W. Harris Pacifica Law Group Treasure Island Fun Run/Walk Tyler R. Andrews Mr. Douglas M. Henrikson Christopher P. Parios and Susan Lee Wyant Trilogy International Partners Ms. Nanci Andvik Bill and Emily Heston PEMCO Mutual Insurance Company Mr. and Mrs. Chris Varley Mr. Robert Angel Mr. and Mrs. Troy Hickey Drs. Carl and Jeannette Pergam Vijay and Sita Vashee Angelo’s Restaurant Mr. and Mrs. Harold W. Hill Mrs. Terry Pero Nancy Greenwood Vehrs and Jeff Vehrs Aon Foundation Mr. and Mrs. John H. Howard Susan E. Peterson Terry and Lara Vehrs Mr. Robert S. Apgood Jim and Heather Hughes Arlie J. Phillips Mr. Robert A. Virkelyst Sophia L. Arain Mr. and Mrs. Raúl Ibañez Christina and Steve Poore W. R. Berkley Corporation Mr. Armar A. Archbold Integrated Archive Systems, Inc. Mrs. Peggy M. Proctor Washington Holdings Jill Argo John Leong Kung-Fu Foundation Project Bionic Washington State Employee Dr. and Mrs. Jay Arlick John M. Gilbertson Foundation PSG Motion Pictures Combined Fund Drive Mr. and Mrs. Charles G. Armstrong Lisa Johnson of Johnson Qualcomm Matching Grant Program Jim and Diane Watson Debbie and Ron Arons International Industries Gail and Larry Ransom David and Marsha Weil Bob and Clodagh Ash Mr. and Mrs. Jason L. Judge Ray and Janet Scherr Foundation Eric and Daria Whettam Mr. Lawrence J. Asher Juno Therapeutics Ream Ink Mr. and Mrs. John Whetzell Alan and C.J. Ashton Mr. James Karambelas REB Enterprises, Inc. Christopher L. and Ruby D. Wilde Mr. and Mrs. Ben Aspen Grace M. Kaylor Estate Mr. and Mrs. Mark A. Reddish The Wilson Sonsini Goodrich & Rosati Auburn School District #408 Gerald and Kaye Kearns Pauline J. Reed Estate Foundation Mr. and Ms. John K. Austenfeld Mr. David R. Kendall Mrs. Sally Reiquam Mr. and Mrs. Donn H. Wilson Geoff and Catherine Austin Mr. and Mrs. Daniel J. Kennedy Residence Inn by Marriott Mr. Mark C. Winmill Avago Technologies Olive Kerry Trust Seattle Downtown Craig and Joan Wrench Ed and Linda Averett King County Employee Carrie D. Rhodes Lee M. Yanik, DVM Sarah C. Avery Charitable Campaign Mrs. Katherine S. Riley Mr. and Mrs. Gary A. Young Thomas and Linda Avery King Estate Winery Room & Board YourCause, LLC Axis Survey & Mapping Molly Lallemand Rose-Marie and Jack R. Anderson Zevenbergen Capital Investments LLC Jane Babione Lane Powell PC Foundation Mr. and Mrs. Alfred A. Baffa Jeffrey Larson Jeff and Anna Rospond $1,000 - $4,999 Bagley and Virginia Wright Foundation Mr. Douglas C. Lawrence Rotary Club of Bellevue The Aadel Askari No Pain Eric Bahna Mr. and Mrs. John S. Leong Rotary Club of Queen Anne No Gain Foundation, Inc. Bainbridge Community Foundation The Lester and Bernice Smith Foundation Calvin and Lauren Rowland John D. Aakre and Cynthia A. Michael Kirk D. Baisch LiveLoud Charities Jon and Judy Runstad Ms. Janet Abraham Duane and Heather Baker Jeff and Ethel Maxwell Mr. Eric V. Salo David and Kristin Acker Mr. Edwin B. Bales Brian and Leasa Mayer SanMar Corporation Robert and Nancy Adamonis Ballard Pediatric Clinic Mr. and Mrs. George L. McCain Jack Schenker Charitable Trust Ms. Susan A. Adams Judith and Richard Ballintine Mr. Jay W. McCain Seattle Procure/Fortis-Construction AC Mr. Richard S. Adatto Chris and Keri Balmer Matt and Wendy McCutchen The Sign of the Orz Adobe Matching Gift Program Suparna Banerjee Dr. Julie McElrath and Dr. Kenneth D. Stuart Silver Cloud Inns & Hotels AEG Management WA, LLC Bank of Tokyo-Mitsubishi UFJ Michael and Heather McKay Isaac and Nicole Sine Aegis Living Bank of the West Employee Giving Program Mr. and Mrs. Peter C. McLoughlin Skanska USA Building Inc. AIG Matching Grants Program Richard and Joanne Barber Merlino Fine Foods Sleep Country USA Mr. and Mrs. Robert D. Alessandro Charles and Linda Barbo Lawrence and Bernice Meurk Mr. Laurence H. Smead Drs. Herb and Charlotte Alexander Morgan and Sarah Barbour Millennium: The Takeda Oncology Company Snohomish County Employees Stephanie Alexander and Michael Wilson Carrie M. Barham Mr. and Mrs. Larry A. Morris Charitable Campaign Alexandria Nicole Cellars Mr. Kevin Barhydt Dr. Elahe Mostaghel Doris Sohmen-Pao Rene Alkoff Barton Family Foundation Ulrich Mueller and Diana Ensenat Stagg’s Precious Metals & Numismatics Mr. Graham Allen I. Georgina Bayley Peter and Wendy Mullen Starbucks Matching Gifts Program Mr. and Mrs. Jeffrey D. Allen Mr. and Mrs. Jeffrey W. Beale Dr. Tomas and Julie Mustelin Dr. Diane R. Staves Allpro Real Estate John and Molly Beaudoin Sally and Kit Narodick Joan and Sheldon Steier and Marcelo Alonso Daniel and Annette Becker NC Machinery Co. Barbara Blywise Alphagraphics Helen M. Beckman Estate Neiman Marcus Allyn Stellmacher and Terry Samilson Mr. and Mrs. Kenneth Alterman Arno Behr and Zelah Kahn Robert and Claudia Nelson Jason and Wendy Stively American Society of Hematology Meru Belbayeva

27 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Mr. and Mrs. Morton A. Bender Bill Brooks, Jr. Gene Chellis and Alla Chellis Mr. and Mrs. William N. Curry Nat and Gail Bender Craig Baylor Brooks and Lisa Chiang Melanie K. Curtice Mr. and Mrs. Albert Bendich Courtney Suzanne Clarke Lisa D. Chinlund Mr. Richard L. Dahlby, LTC USA Ret Mr. and Mrs. Leon Bene Mr. and Mrs. Dean J. Brooks Tana L. Chmieleski Gerald Daily and Janet E. Freeman-Daily Dr. Ronald and Cheryl Berenson Michele Brooks Wyman F. Chong Janice and Jim Dameron Mark Berggren Bradley and Amy Brotherton Mr. and Mrs. LeRoy R. Christiansen Mr. William Daniels Mr. and Mrs. Scott T. Berglund Bryan and Joy Brown Ba Kang and Xiangyu Chu Marjorie and Ronald Danz Jeff and Lisa Berkman Mr. Charles M. Brown Zita M. Chubbuck Dr. Thomas R. Darden and Linda and George Berkman Darryl and Adriane Brown Ki-Hyun Chun Ms. Ellen J. Wallach Dr. Stanley S. Berman Mr. and Mrs. David A. Brown Cinebarre Mr. Nelson J. Darling, Jr. Erin and Ethan Bernau Roland and Julie Brown City Catering Kari Darnell Victor Bernstein and Gail Landis Ivan Brugiolo Mary C. Clare and Ryan J. Hall Shelly P. and John DaRonche Nick Berry Ms. Melinda A. Buckley Mr. J. Terence Clark Jodi and Tracy Daugherty Bertram and Suzanne Schild Builders’ Hardware & Supply Company, Inc. Mr. and Mrs. Roland B. Clark Sylvia M. Davids Charitable Foundation, Inc. Simone Buntin Simon Clarke and Alice Burden Mr. Lucy A. Davies Beta Sigma Phi Tau Master Charles Burdell Mr. and Mrs. James Claypool Miss Chelsea Davis Chapter of Tacoma WA Ms. Pamela Z. Burden CleanScapes Inc. Dick and Maryanne Davis Ken and Shiori Betzler Steve and Gayle Burditt Deborah Cleveland Jane and David R. Davis Mr. Gary R. Bezowsky and Linda and Paul Burg Dr. Bruce Clurman and Ms. Deb Gumbardo Louise P. Dawson Ms. Donna R. Evered Randal C. Burge Mr. Harold Cochrane Dr. Robert W. Day Gwendolyn R. Billington Bryce and Brooke Buri Mrs. Deborah B. Cohen Bill and Wilma De Leeuw Mr. and Mrs. Rodney B. Bindon Lance and Holly Burkett Mrs. Peggy Coker Mr. John R. Deboben, Jr. Michael M. Bini Sharon R. Burkhardt Coldstream Capital Management James R. Degarimore Estate Bishop Fleet Foundation Lauren L. Burman Robert and Dana Colon Mr. and Mrs. William T. Deibel Mr. G. W. Bishop Mr. and Mrs. Steve Burns Mr. Frank E. Colson Mr. Thomas H. Delimitros Kim Lyford Bishop Christopher M. Burrows Columbia University Dave and Tracy DeLorm Stephen and Julie Bishop Matt and Alli Burton Combined Federal Campaign of Denver Bouldering Club BizX Carl and Angela Bush Kitsap-Mason Counties Curt and Anita Dieren & Sons Hans and Julie Bjornestad Judy and Ward Bushnell Combined Federal Campaign of The Dillard Foundation Laurie Black and Stafford Mays Mrs. Jane Buttice South Puget Sound Din Tai Fung Restaurant Inc. Blaze Biosciences Ms. Becky Byrd and Mr. Owen Ashurst Peggy Confer and James Thompson Ms. Marybeth E. Dingledy John E. Bleichner, Jr. and Carol F. Bleichner Dr. David R. Byrd Dr. Margaret W. Conkey and DiPietro Family Foundation Mr. Arnold Blinn and Ms. Leslie Brewer C. James Judson, Inc. P.S. Dr. Lester B. Rowntree DKS Associates Mr. and Mrs. Peter C. Boal CAC Real Estate Management Co., Inc. Greg and Erin Coomer Eric and Tracy Dobmeier William A. Bock Mr. Gary Caldwell Copacino + Fujikado Jim and Cam Dobrick Mr. Charles J. Bodenstab and Calidora Skin Clinic Skinlux, Inc. Dr. Shannon Corbin and Dennis and Anne Doherty Ms. Donna D. Martin Mr. and Mrs. Roger L. Callihan Mr. Jonathan M. Tingstad Mr. Kaspar Donier Dr. and Mrs. Michael Boeckh David and Debra Campbell Shaun E. Corry Toby and Bill Donner Sandra A. Boeskov Susan and Jerald Campbell Barbara and Kevin Cosgriff Alexander and Hilary Doroski Kirk and Sue Boettcher Erica and Jose Campos Costigan Integrated LLC Mr. Jeff J. Dossett Mr. and Mrs. Michael A. Booth Ruth Cannon Christine Cottrell Rose M. Dotson Deborah Boutinen Capital Group Mr. and Mrs. James A. Coulson, Jr. Leann O. Doussett Diane E. Bowers Mr. and Mrs. Tom Captain Covidien Employee Matching Gift Program Ms. Katherine H. Dovinh Jim and Kathy Bowman Katherine T. Carey John and Kathryn Cox Patricia E. Doyle Lee and Holley Boyd Carl Hossman Family Foundation Derron and Tammi Craft Dr. and Mrs. T. Michael Doyle Mr. and Mrs. Robert D. Boyd The Carol and Mort Goodman Fund of the Heather Craig Traci L. Drake and Ann Torres Eileen and Connell Boyle Jewish Community Foundation Robert B. and Robin R. Crandall Ms. Carla M. Dramer Mr. Michael P. Boyle Mr. David Carrell and Dr. Garnet Anderson Mr. Fred Crosetto Dr. and Mrs. Charles W. Drescher, M.D. Tony and Evelyn Bozzuti Jeffrey and Kim Carroll Kristy Crouse Drivetime Car Sales Brackets for Hope Jim Carroll Cal and Lois Crow Julie and John Duggan Mr. Mark A. Brandjord Mr. and Mrs. Paul A. Carter Mr. and Mrs. Vincent K. Crow Mrs. Mary E. Dunlap Mr. Dennis Brass Mr. William G. Carter, PhD Barbara L. Crowe Mr. and Mrs. Joseph M. Dunn Ms. Elizabeth Braun Mr. Timothy Casey Ryan and Elise Crumpacker Mr. and Mrs. James A. Dunnam Mark D. Bray Cedergreen Cellars Dr. James P. Crutcher, Jr. Dunphy McLean, Inc. Aaron Bregel Mr. and Mrs. Steven D. Cedergreen CST Tires (Cheng Shin Rubber USA, Inc.) Hazel Duplissea Estate Mr. Wayne L. Bridges, Jr. Nicol R. Chadek Mr. Sylvester T. Cugini Mr. Eric Durban Mrs. Christine L. Brinton Mr. Stephen J. Chaney Mr. Ned N. Cumle John and Marlene Durbin Stephen and Stephani Briscombe Mr. and Mrs. Kent P. Chaplin Jeffrey and Lorine Cummings William and Jane Durch Bristol-Myers Squibb Foundation Dr. Joseph B. Chastain Brian and Elise Cunningham Mrs. Phil Duryee Todd, Mary and Geary Britton-Simmons Steven and Michelle Chattin Cupcake Royale Todd and Virginia Dutkin Mr. Christopher J. Brock Dr. Roki Chauhan John and Judy Curran Michael and Diane Dwyer Brooks Sports, Inc. Dr. and Mrs. Martin A. ‘Mac’ Cheever Thomas and Rhonda Curry Pete and Phyllis Dybsand

28 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Patricia L. Dykema Dan and Barbara Fiorito Mr. and Mrs. Mark Goldhammer Harrelson Family Mr. and Mrs. Christopher M. Eagan First Federal Miss Kelley E. Goldmanis Dr. Brian and Lyn Harris Karla L. Easton Mr. and Mrs. Chad J. Fischer Sara and Gideon Goldstein Mrs. Peter H. Harris Mr. Kevin Eckert Mrs. Stacey R. Fischer and Mr. Alan L. Goller Mr. Robert M. Harris, Jr. Mr. and Mrs. Charles K. Ede Mr. Ron B. Robinson Mr. and Mrs. Abraham M. S. Goo Kevin and Bobbi Harrison Julie Edsforth and Jabe Blumenthal Eulalie M. Fisher Dr. and Mrs. Edward L. Goodman Scott and Darel Harrison Jeffrey and Karen Edwards K. Joan Fisher Google Matching Gift Program Hart Crowser Inc Kay Edwards Ms. Rose A. Fisher Douglas Gordon Peter and Pat Haug Caroline Egan Mr. and Mrs. Matthew T. Fitch Mr. and Mrs. Richard K. Gordon Mr. and Mrs. Steve S. Hawes Mr. and Mrs. Robert D. Eggers, Jr. Mrs. Patricia Fitzpatrick Katie Gotshall Edwin F. and Noriyo Hawxhurst Robert N. and Ingrid Lahti Eisenman Mr. Tom Flookes Mr. and Mrs. William G. Gottschalk Denise Hayashi Element Cycles Donovan R. Flora Gottstein Family Foundation Holly Hayes Allan and Peggy Elenbaas Mr. Roger H. Forbes GPMCH Foundation Jeff Hazeltine and Alicechandra Fritz Tracey and Mike Elfstrom Ms. Kris Forth Mr. and Mrs. Paul Graham HCC Specialty Jerry E. and Julianne C. Elkington Four Seasons Hotel Seattle Roger and Jennifer Grambihler Alexandra and Adam Hedin Mr. and Mrs. Paul G. Ellingson Mr. Gregory Foxman Benton and Caroline Gray William and Joyce Hedin John and Farida Elliott Heather Franklin Mr. and Mrs. Lee M. Grayson, Esq. Mr. and Mrs. Severt S. Hegland, Jr. Mr. and Mrs. Richard B. Elliott Mark and Jayme Freeborn Cameron and Elizabeth Green Mr. Kenneth W. Helgeson Mr. Robert F. Elliott and Linda J. Freeburg Mr. and Mrs. Ronald Green Mr. and Mrs. Ralph E. Hemingway Ms. Margaret E. Taylor Jayne and Eric Freeman Mr. Sean Green Todd and Stephanie Henderson Dr. and Mrs. Harley Ellman Freestone Capital Managment David Greenberg Justin and Catherine Hendrickson Mr. and Mrs. Jeffrey B. Ellman, Esq. Mr. and Mrs. Dan Frei Mr. and Mrs. Carl A. Greenfield Tom and Mary Herche David and Barbara Ells Stan and Cindy Freimuth Governor Christine L. and John and Diane Herfort Emery Reddy PLLC Marie J. Friend Michael J. Gregoire Mr. and Mrs. Robert W. Herrington Mr. Timothy W. Emery Mr. Lloyd D. Frink and Ms. Janet E. Angell Matt Griffin and Evelyne Rozner Melissa and Shawn Herron Emissary Press Lisa Fritzky Shelly Griggs Mr. David Hersey Mr. Larry J. Engel Ryan L. Fritzky and Susie M. Fritzky Mr. and Mrs. Charles G. Grinstein Richard and Marilyn Herzberg Alyssa D. Englund Kyle and Katrina Fukuchi Jay R. and Cynthia L. Groepper Hewitt Darrin and Stefanie Erdahl Mr. and Mrs. Jepson S. Fuller II Mr. and Mrs. Roland M. Grotte Con Hewitt Dr. Bruce and Veronica Erhart Chad and Jeri Dee Fullerton Jennifer and Bryan Grusz Mr. James B. Hewson Dr. Marc and Maria Erlitz Mark and Annelise Gaaserud Sharon L. Guldjord Rocky and Genie Higgins Ernst & Young Foundation John Gadon Mr. and Mrs. Scott Harlow Gulick Hilen Foundation Mr. and Mrs. A. Herbert Ershig Phil and Lisa Gafken Mr. and Mrs. Nils M. Gunther Mr. and Mrs. Merle Hill Ms. Tobi Erskine J. James and Margel S. Gallagher Pooja Gupta Steven and Taeko Hill Mr. and Mrs. Mark Eshom Dr. Denise Galloway Susanne and Scott Guthrie Fred and Dawn Hines Mr. Michael D. Eskenazi Sharon Garcia Charlotte R. Haag Michael and Rosemarie Hitt Ethel Silvergold Philanthropic Fund of the Mrs. Lori Gard Jessica Michel Hagan and Curtis Hagan Brent and Dulcy Hixson Dallas Jewish Community Foundation Mary E. Gardner Mr. David Haglund Dr. David M. Hockenbery, M.D. Grant W. Eve, CPA Michael Gasser Justin Hagood Gregory and Joelle Hoff Mr. Joseph P. Eve and Sheri and Omri Gazitt Collin and Jillian Hagstrom Mr. and Mrs. Harold L. Hoffman Mrs. Melanie Vankoten-Eve Nandita and Jochem Geerdink Kenneth Hahn and Louis Mangual Mr. and Mrs. Brian D. Hogan Everett Theatre Group Daniel and Lisa Gemme Ms. Pamela Haldeman Scott and Debbie Holbrook Evergreen State Project Vanessa Gemmell Mr. and Mrs. Charles V. Hall Scott and Joanna Holden Mr. Dennis Evseev Mark and Deborah Gentzen Maureen Halligan and Frank Brennan Carolyn M. Holdorf Kerry and Michael Fagelman Geoffrey R. Monk Family Charitable Fund Sajva Halverson Shane and Kim Hollett Carole Faltermeier Mr. and Mrs. Bob George Mr. and Mrs. Elling B. Halvorson Ian Hollier Norris and Alice Faringer Jane Gerhardt Anne M. Hamilton Robert and Ruth Holmes Rachel and Edward Farrell Mr. Richard L. Gerhardt Mr. Charles E. Hamilton, Jr. Sarah C. Hopkins and Anirudh Bansal Folashade Fashokun Tom Gerlach and Leigh Stokes Mrs. Maureen K. Hamilton Bob and Melinda Hord Mr. Jonathan Fast Mr. Trevor Gerszt Lois M. Hanaoka Lewis and Lisa Horowitz Gary and Mary Fedorochko Mr. Paul Ghaffari Mr. and Mrs. George E. Handtmann III Dr. and Mrs. Karl Y. Hostetler Mr. and Mrs. Jon Fehrenbach Dr. Kenneth E. Gibson Kathryn Haniuk Mr. Larry T. Houdek Feinberg Foundation, Inc. Mr. and Mrs. Robert H. Gies Dave and Sandy Hanower Mr. and Mrs. Henry L. Howell Mr. and Mrs. Robert S. Feinson Alan and Jeanine Gilchrest Ann Fisher Hanson Mr. and Mrs. Lembhard G. and Matthew and Heide Felton Shelley and Lee Gill John Martin Hanson and Sharon Ann Hanson Marjorie P. Howell Dr. and Mrs. Matthew L. Fero Mr. Thomas W. Gille The Harbor Club Mr. and Mrs. George E. Howison John and Margaret Fiala Mr. Charles W. Glass Ms. Janice C. Harding and Mr. Warren E. Olson Mr. and Mrs. Barry Hoyte Alison Fields Glen Carbonic Gas Co. Ms. Gayle R. Hardt Mr. Robert H. Huffman Mr. Frederick D. Fiene Mrs. Nancy Glickman Felix and Sara Harke Trevor and Donabelle Huffmaster Fifth & Lenora, Inc. Mrs. Miriam Glover Jennifer Harnish Mrs. and Mr. Lauren Hughes Scott and Amy Finholm Fred Goldberg and Carolyn Lakewold John and Elena Harnish Shannon and Troy Hull Finn Hill Winery Mr. and Mrs. Stephen N. Goldberg Walter and Angela Harp Olivier and Catherine Humbert

29 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Hulda F. Humola Estate Lynn and Sharon Kasel Mrs. Wilma M. Laity Brent and Kathleen Lower C. Dan and Irene W. Hunter Ms. Theresa A. Kaser Mr. and Mrs. Peter C. Lamb Mr. and Mrs. Robbie Lowery Gerry Hunter Tomasz Kasperkiewicz Yvonne P. and Jack Lamey Claudia R. Luebbers Mark and Mollie Huppert Ms. Heidi Kass Moe Lance Mr. and Mrs. Nat J. Luppino Mr. Bob Hurlbut Kaufman Borgeest & Ryan LLP Jeffrey and Lisa Lanctot Luther and Zita Templeman Foundation John and Bonnie Hutchinson Jim Kaufmann and Mary Thrasher Mr. Stewart M. Landefeld and David and Deborah Lycette Scott and Amy Hutchinson Nancy Kaufmann Ms. Margaret M. Breen Pamela and Charles Lyford Dr. and Mrs. Stuart R. Hutchinson Sharon Kean and Robert Lipson Richard and Gaylin Landeis Mrs. Susan P. Lyon Mr. and Mrs. William B. Hyde Mr. and Mrs. Thomas W. Kearns, Jr. Carol J. Landis The M&T Charitable Foundation IBM Employee Services Center Mr. Gregory P. Keith Mr. and Mrs. Michael W. Landry Dennis Ma and Vannessa Nhan Mr. and Mrs. Paul Thomas Idzik Jeremy and Wendy Kelly Lands’ End Greta Ma IMG Mr. John A. C. Kelly Mr. and Mrs. Robert C. E. Laney Mr. Kent Madera Informatica Mr. Gary J. Kelmel Amy Lang Madrona Venture Group Inn at the Market Kemper Holdings Inc. Ms. Toby C. S. Langen Ms. Jennifer A. Magyar Anne Irwin Patrick and Melissa Kennedy Arthur K. Langlie Mr. Robert Mahler and Ms. Joanie B. Warner Denise and Brian Ivie Mr. and Mrs. Robert J. Kenney, Jr. Mr. Eric Larsen Randy and Retta Main Margot Jackler and Paul Flowerman Mr. and Mrs. Brice Keown Mr. Christopher R. Larson Mr. and Mrs. Michal T. Makar Angela and Fred Jackson KEXP 90.3 FM Mr. Dave N. Larson James and Sheila Mallahan Mr. and Mrs. Arthur D. Jackson, Jr. Shaheed Khan Mr. John W. Lash Mr. and Mrs. David M. Malone Mr. Michael Jackson and Ms. Christy Martin Niraj Khanchandani Mr. James Latore Michael and Barbara Malone Mr. Dana Jacobs Kia of Puyallup Mr. and Mrs. Wayne Lauerman Fred and Ruth Maloney Hanan Jacoby and Benu Bidani Mr. and Mrs. Eldon W. Kiel Amy and Aaron Lavin Helen and David Mandley Don and Julie James Dr. Hans-Peter Kiem and Richard and Rosemary Law Ms. Joy T. Mann Mr. Paul F. James and Mrs. Dana Swenson Paul and Suzanne Lazarov Mrs. Sue L. Mann Mrs. Ouida M. Hemingway Benjamin F. Kilgore Mr. and Mrs. Timothy Leahy Mr. and Mrs. Jeffery A. Maple Pierre and Christine Jammes Mr. Robert E. Kilian Kari Leal and Sandra Matteson Marcraft Clothes, Inc Bo Janes and Derek Eisel Mr. and Mrs. Myung Joon Kim Leavitt Capital Companies, Inc. Mr. Donald E. Marcy Mrs. Dawn Jasper Susan Kim Michael and Leslie Lebeau Dr. and Mrs. Stephen I. Marglin Jed and Celia Meese Foundation Jerry and Marcia Kindinger Mr. and Mrs. Philip A. Leder Marketaxess Corporation David and Elisabeth Jenni Mr. Andrew L. King Sylvia Lee and Glenn Kelman Brett Markowitz Kurt and Clair Jensen Dr. Anne B. King John J. Legere David and Vicky Marsing Lois Jepson Tonya and Darryl King Constance Lehman, M.D. Mr. and Mrs. Victor Martino Mrs. Carol A. Jeuell Kyle Kingma Daniel A. Lelewski Mary E. Martinson JKU Foundation Leigh Kinnish Mr. and Mrs. Peter R. Lemman Sue and Bill Mason JM Curley Restaurant Lauren Kisser Kimberly and Thomas Lengle Neal and Brandi Massie Mr. Robert D. Johns Brian and Melynda Kite Mr. and Mrs. John Lester Master Shon Tae Kwon Do Center Allen and Carleigh Johnson Mr. Michael D. Klansnic Pamela S. Lester MasterPark Airport Parking Brent and Catherine Johnson Lynette A. Klein Dr. and Mrs. Sidney H. Levine Keith Mathews and Cathy Fallen-Mathews Chris and Jenny Johnson Ms. Suzanne Klein Margot J. Levy Erick Matsen Ms. Christine K. Johnson Lynette and David Klingeman Dr. and Mrs. Steven A. Levy Matthew Blend Fund Elaine H. Johnson Dr. John Klippert Lewis River Ladies Golf Assoc. Bev and Jim Mauser Mr. and Mrs. George P. Johnson Robert M. Knappe David and Dana Lewis Ryan and Sara Maxwell Jeffrey and Paige Johnson Jeffrey and Michelle Knoll Don and Carla Lewis Dr. Nina Mayr and Dr. William Yuh Mr. Josiah Johnson Carly Knox Jerrold Liebermann and Linda J. Harris Mr. and Mrs. Mario Mazzola Karen and Scott Johnson Carol and Steve Koehler Mrs. Edith M. Liias Tod and Christa McBryan Ms. Nancy S. Johnson Mr. James J. Kohrman Mr. and Mrs. Terron R. Lindholme Mr. and Mrs. Theodore E. McCaffray, Jr. Preston Johnson and Vicki Martin Mr. Phillip and Mrs. Kathleen Kolczynski Clark and Lori Lindsay Ryan McCallen Mr. Richard A. Johnson Dr. Kenneth J. Kopecky and Peter and Sarah Lindsay Mark McCasey Sarah J. Johnson-Sauser Mrs. Kathleen A. Kealey Mr. and Mrs. William G. Lindsay C. Edward and Maureen B. McConnell Mr. and Mrs. J. Michael Johnston Nora Korg Alexander Lindsey and Lynn Manley Michelle L. McCormick Mr. Paul R. Jokisch KPFF Consulting Engineers Ms. M. Suzanne Linford Mr. Randy McCourt Andrea Jones KPMG LLP Mr. and Mrs. Harry A. Linker McCullough Hill Leary Rich and Aimee Jones James Allen Kraft and David A. Little and Michelle A. Gray Mr. and Mrs. Richard B. McCune Susan T. Jones Dominique Patricia Posy Matt and Elisha Logue Mr. Michael G. McCunn Tyler and Anna Jones Mr. and Mrs. Michael A. and Dr. Yince Loh and Ms. Kathyryn Oliver Ms. Mary L. McCurdy Dr. S. Abraham Joseph Sharon L. Kramer Mr. and Mrs. David B. Lomet Mr. and Mrs. Robert D. McDonald Peter and Angela Junger KristenzKure Mr. and Mrs. G. Michael Losh Ms. Michelle M. McDonough JustGive.org Mr. Quentin Kuhrau Lott Foundation McDowell Family Mrs. Carla H. Kaatz Dr. and Mrs. Thomas Kun Jeffrey and Jennifer Lounsberry Mr. Roger T. McDowell Mr. and Mrs. Kim J. Kaiser Richard Kyle and Kara Matthew Carl M. Lovsted Ian McFarland Jeanne Kanach The Lacy Foundation Carl and Carrie Lovsted Mr. and Mrs. Nick McFarland Mr. Harvey Kanter Mr. Daniel LaFond Mr. and Mrs. Russell D. Lowell Stacey McFarland

30 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Ms. Mary L. McGeough Mr. and Mrs. James B. Murphy Mr. and Mrs. Randall J. Ottinger II Robert and Victoria Quiles Mr. David L. McGoldrick Mr. James P. Murphy Robert B. Overhus R.D. Mushen & Associates Anne T. McGonigle and Gregory M. Witter Stanley Myer James T. ‘Jess’ Owen Gus Raaum Lanny R. McGrew Dr. Geraldine Myles Pacific Market International Rack Petroleum, Ltd. Joan Ellen McInerney, MD FACEP Dr. Narmeen Nabil and Dr. Saeed Humayun Mr. James D. Paddleford and Dr. Jerald Radich Niki McKay and Dave Jungck Dr. Keyvan and Parvin Naficy Mr. Dent W. Davidson Ram International Co., LLC Mrs. Lisa McKelvey Mr. Yasumi Nagai Pagliacci Pizza Mrs. Ann Ramsay-Jenkins Mr. and Mrs. Gerald J. McKinney Mr. and Mrs. C.V. Nalley Mr. and Mrs. James Golden Pappas Chris Randall McKinstry Ms. Nancy Narraway Mr. Paul S. Pariser Michael and Linda Ranz Doug and Ruth McKnight Dr. and Mrs. Richard Nash Virginia L. Park Spencer and Nanci Rascoff Tim and Teri McLean Nativis, Inc. Mr. and Mrs. John M. Parker Michael and Susan Raskin Mr. Geoffrey P. McMahon and Mr. and Mrs. David W. Neal Ms. Irene S. Parkhill, DDS Rich and Betty Rasmussen Ms. Deborah L. VanDerhei Ann and Stanley Nelson Lynn C. Patten Mark and Julie Rathbun Kimberly McNally and Mark Sollek, MD Mr. Michael B. Nelson Franci E. Pease Mr. and Mrs. Robert A. Ratliffe Mark A. and Marna L. McNaughton Mr. Paul F. Nelson Karen Pease and Bob Barlow Mr. Thierry Rautureau Bill and Nicole McNichols Dr. Peter S. Nelson Mr. and Mrs. Brandon S. Pedersen RealNetworks Foundation Cole and Kathryn Meckle Network For Good Catherine L. Peichel and Steve Froggett Alexandra Rector Mr. and Mrs. Frank T. Medici Mr. Kurt Neuharth Mark and Nancy Pellegrino Red Carpet Valet Yazmin Mehdi and Liam Lavery Dr. Marian L. Neuhouser, PhD Molly Pengra Felix and Pavana Reddy Menashe & Sons Jewelers Peter and Sheryl Neupert PepsiCo Patrick B. Reddy Mr. and Mrs. Jack J. Menashe Katharine and Stephen Newman The Peras Paul and Charlotte Reed Merck Partnership for Giving Mr. and Mrs. Michael Newsome Dan and Stephanie Peters Andrea L. Reese Pipena Klieros Mercouriadis Mr. and Mrs. W. Paul Nichol Dale W. ‘Corkey’ Petersen Reformed Church in America Rob and Rachelle Meredith Todd and Marci Nicholson Donald B. Peterson and Cecilia M. Giachelli Gerald J. Reilly Aaron M. Merhoff Mr. Thomas Niepokoj Janet and Eric Peterson Mr. and Mrs. Marvin Reiner Metals Fabrication Company, Inc. Mark and Sue Nikiel Kemp C. Peterson April Reitan Louise H. and Edward R. Meyer Noble Wines Mr. and Mrs. Randal L. Peterson Srilata D. Remala Memorial Trust Mr. and Mrs. Ryan M. Noel Steve and Sue Petitpas Maurice Rice Mr. David J. Meyers Trevor and Marci Nolan Cynthia and Roger Petrie Mr. and Mrs. James C. Richards Michael Adair Family Foundation Nomada Endowment Fund Elizabeth and Benjamin Petter Mr. and Mrs. Michael R. Richards Mike Carrell Med Assist Fund Ilse Nordmann and Jorn Nordmann Bill and Kathy Pettit Terry and Benton Richardson Mile High United Way Frederick Bowen Northup, Jr. and Pfizer Foundation Inc Dr. and Mrs. Stanley R. Riddell Mill Creek Sports Cards Ashley K. Northup Philadelphia Area Combined John Rieke Mr. and Mrs. Alan G. Miller Northwest Motorsport Federal Campaign Mr. and Mrs. Charles W. Riley, Jr. Barbara A. Miller and Anne E. Nicoll Mr. Vern A. Norviel Mr. Richard N. Phillips Ms. Susan Ringoen Mr. Daryl J. Miller David Notario and Latife Lacin George and Cynthia Pierce Mrs. Jerene F. Ripstein John and Joyce Miller Dr. Dodi and Rachael Nov Mr. and Mrs. Mark R. Pierce RJ Smith & Associates Michael and Lisa Miller Beatrice H. Nowogroski Mr. and Mrs. Guy C. Pinkerton Joyce E. Robbins Peter Miller and Jean Johnson Elizabeth A. Nuchia Mr. and Mrs. Derek Pizzey Bruce and Diane Robinson Tammy Miller Margaret O’Brien Carl and Donna Platou Craig and Jessica Robinson Milliman Michael and Esther Ochsman Mr. Gregory L. Plaunt Mr. and Mrs. Jim D. Robinson Rick and Joyce Miner Mr. and Mrs. Victor D. Odermat Dr. and Dr. Stephen R. Plymate Paul and Evelyn Robinson Ben Minicucci and Barbra Rigelhof Mr. and Mrs. Michael D. O’Donnell PNC Institutional Investments Barry and Debbie Rochefort Kelly and Martin Minnaar Tim Oerting William and Ricca Poll Rockwell Collins Ms. Barbara Moffat Mr. Daniel Ogg Mr. Richard Popiel Jeff Rodgers and Deborah Barge Rodgers Dr. and Mrs. Kendall M. Mohler Carol R. Ohlmacher Mr. William L. Portmann Brian J. Rogers Molly Moon’s Homemade Ice Cream LLC Dr. and Mrs. Jeremiah V. Ojeaburu Post Advisory Group, LLC Mr. and Mrs. Dennis W. Rohling Molten USA, Inc. Janice R. O’Keefe Darin Postma Carol Roll and Joe Mills Robert P. and Lucille L. Mone John Okino Mr. and Mrs. William W. Potter James and Jane Roll Mr. and Mrs. Geoffrey R. Monk Richard and Janet Olin Caleb and Ann Powell Mr. and Mrs. Kenyon B. Roll Mr. Larry G. Montague Mr. and Mrs. Homer Olsen Lauren R. Powell Koryn E. Rolstad Mrs. Andrea G. Montaque-Behrens Steven and Crystal Olsen Mr. Morton M. Poznak Rose and Tiger Foundation Dr. and Mrs. R. Bruce Montgomery Kaven and Gary Oltman Nicole and Michael Pratapas Mr. and Mrs. Alan J. Rosen Woody Morf and Peggy Skillin Mr. and Mrs. Richard J. Omata Kathleen Walker Pratt Deborah and Douglas Rosen Morningside Foundation Dr. Gilbert S. Omenn Mr. and Mrs. Ryan Prentice Mimi Rosen and Nathan Goldberg Ms. K. Terri Morris Sheila and Mel O’Neal Cassandra and Allen Prescott Sheri and Andrew Rosen Mr. and Mrs. Charles H. Morse, IV Mr. and Mrs. Shane O’Neil Elizabeth Prescott and Daniel Stetson Stephen and Jill Rosen Ro Jean Mount Michael Orbino Mr. John P. Prillaman Stephen and Elizabeth Rosenman Mahlon M. Moyers Paula and John Orehek Eric Prock and Tracy Sullivan Prock Mr. and Mrs. Steven T. Rosenthal Lisa Mudgett Judith A. Orr Mr. Bradford A. Proctor Ron and Nadean Ross Mrs. Catherine Mullin Cynthia and Thomas Ostermann Puget Sound Personnel, Inc. Dr. and Mrs. John Rossi Craig and Marie Mundie Jesse and Jennifer Ottele Bruce and Celia Pym Brian and Deborah Rowe

31 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Ms. Shannon G. Rowe Matthew and Kathryn Sentena Joseph and Jennifer Sprague Mr. and Mrs. Ed Thomas Royal Ridge Fruit Mr. and Mrs. John C. Sercu Ms. Laura L. St. Germain and Jim and Paula Thomas Mr. and Mrs. Darren K. Rozendaal Michael and Susan Servais Mr. Cyrus Gorman Ms. M. Jane Thomas Pam and Mike Rubin Douglas and Carol Sevier Ron and Mary St. Martin Ms. Elisa F. Thomases Bill and Jill Ruckelshaus Todd and Ashley Sevier St. Regis Sanya Yalong Bay Dick and Ruth Thomassen Mr. John Rumpeltes Kim Sexton Catherine and Brent Stach Thompson LES Scott and Susan Rusch Doug and Lisa Shaeffer Traci Staffen Beti Thompson Russell Matching Gifts Program Kabir and Noreen Shahani Mr. Robert W. Stafford, Jr. Mikal and Lynn Thomsen Mr. Kenneth J. Russell, M.D. Omar and Lora Shahine The Standard Employee Giving Mr. and Mrs. Robert W. Thomson Tom and Jeannine Ryan Mr. David M. Shank Campaign Employee Donations Thorsen French Advocacy, LLC Andrew Ryder Peter and Amy Shaper The Stanley B. & June L. Rose Foundation Barbara Thrasher and Rick Koffey Irada Sadykhova Mark and Susan Shapiro Loretta G. Stanton Estate Alison Tierney Sagacity Media, Inc. Frank and Suzanne Shaw Chef Scott Staples Ms. Bonnie Timm and Sara Sage Kristin and Aaron Shaw Dr. and Dr. Gordon A. Starkebaum Mr. Gregory A. McFadden salesforcefoundation Mr. Monty Sheldon Robert and Pamela Steeg Mrs. Perry Tirschwell Mr. and Mrs. Gerald M. Salkowski John W. Shelor, Jr. Mr. Patrick S. Steele Andrew and Shana Tischaefer SaltChuk Resources, Inc. Elaine C. Shepherd Steen Family – Houston, Texas Titan Electric, Inc. Catherine D. Sands Sheraton Hong Kong Hotel & Towers Mark and Judith Stein The Titus Will Families Foundation Justine and Rob Sands Sheraton Waikiki Hotel Mr. and Mrs. Larry Steinberg Tom Douglas Catering & Events Mr. and Mrs. Rob Sanford Emily Sheridan Mr. Seth Steinberg and Ms. Candace Kalish Gregory and Marilyn Tompkins Sangamo BioSciences, Inc. Mr. and Mrs. Peter A. Shimer Ms. Kathleen Stetson Mr. and Mrs. Jorge Tosar Mr. and Mrs. Joel R. Sarfati Jason J. Shinn Stewart Title Guaranty Company Towers Watson Patti Savoy Kurt and Kylee Shintaffer Ms. Jessica D. Stewart Carol Tranfaglia and Timothy Osborne Mr. and Mrs. Joseph S. Saxon, Jr. Mr. and Mrs. Jon M. Shiozaki John and Genie Stewart Barbara Trask and Ger van den Engh Mr. Charles A. Saylor, Jr. Elizabeth M. Shipley Mr. and Mrs. Michael Stewart Caroline and Joshua Traube Erik and Candace Scairpon Mr. William S. Shipley III Mr. Charles L. Stoddard Dr. Joseph Traube and Dr. Christine White Mr. and Mrs. George Scarlett Mrs. Jennifer L. Shong Sonya Stottlemyre Lauren T. Trescott Dr. Stewart M. Scham, M.D. Clay Siegall Luke Stroud Tri Area Pharmacy LLC Nancy Schenck Sigma Kappa Mr. Robert L. Strum Andrew Triphon David and Lisa Schilling Woody and Karen Sillifant The Stubbeman Family Foundation Mr. Aaron M. Trolia Gena and Alex Schirer Dr. and Mrs. Russell R. Silverstein Joan E. Studley Ms. Leslie E. Trout Mrs. Janet M. Schlameus Mr. and Mrs. Marlund A. Simchuk Brian and Gina Summers TRUEbenefits, LLC Beth and Chris Schmaltz Mrs. Audrey A. Simmelink Sunshine Cafe Dr. Toshio Tsukiyama Ms. Erika and Mr. John F. Schmidt Mr. Richard P. Simmons Mr. John M. Supera Shirley K. Tsuruoka Schoenfeld-Gardner Foundation Mr. Gus Simonds Kyle and Emi Suzuki Ian and Leslie Tubbs Matthew Schoenholz Andrew, Judith, Harriet and Tobias Sinclair Michael Swafford Gary and Amanda Tucci Mr. and Mrs. William K. Schoening John D. Sisler, Jr. Gerald and Elizabeth Swan Ms. Jean Q. Tuesday Mr. Paul M. Schofield Sisters Schools Foundation Mr. and Mrs. Jordan Swanson Ms. Heather Tuininga Mr. Charles F. Scholl, Jr. Mr. and Mrs. H. M. Sizemore Scott Swerland Mrs. Marcia Tulloss Keith and Jennifer Schorsch Jennifer Sizemore and William Hawn Kathryn A. Sweyer and Chris Berta Mr. and Mrs. Robert E. Tutland Daniel R. Schroeder The Skier Foundation Dr. Michael and Peggy Swistak Jim and Pat Twisselman Ms. Monica Schroeter Ms. Barbara Slack Symetra Gives UBS Matching Gift Program Mr. and Mrs. Alan W. Schulkin Stuart Sloan Dr. Daniel Syrdal Supriya Uchil Patrick and Dianne Schultheis Mr. Scott J. Smiles Sysco Central Pennsylvania, LLC Luis and Colette Ulloa Schwartz Brothers Restaurants Mr. and Mrs. Gary S. Smith Monte and Nan Szendre Mr. Jerry E. Ulmer Mr. David J. Schwartzer Gerry Smith and Vicki Halper Shane and Alexis Tackett Unico Properties LLC John C. Scibek Mrs. Jenna L. Smith Mr. and Mrs. Robert J. Taller Union Bank, N.A. The Scott E. Silver Family Foundation Mr. John N. Smith Sarah and Casey Tallon Unionbay Sportswear Ann Scott Kelly E. Smith Mr. and Mrs. Stephen G. Tandy United Way of the Columbia-Willamette Steven Scott and Kristin Houser Orin and Janet Smith Dana and John Tanner United Way of Greater Los Angeles Walter and Karen Scott Mr. and Mrs. Robert J. Smith Don and Sharon Tapley United Way of the Quad Cities Area Janet Sears Mr. and Mrs. Russell J. Snyders Mr. Lawrence E. Taylor Radhakrishna and Lalita Uppala Seattle Cancer Care Alliance Janet and Gary Somers Ted McDowall Memorial Tournament Va Piano Vineyards Seattle Seahawks Janice J. Sorensen Mr. Barry K. Telsey Madina Vadache Seattle Sounders FC Jay and Lorie Sorensen Dan Temkin and Lori Brennan Anthony and Patricia Van Ruiten Seattle Sounders Women Southern Wine & Spirits of the Cheryl D. Tenney Dustin and Elizabeth Van Wyck Ms. Teresa Sebert Pacific Northwest Mr. Lyle Tenpenny Danielle and Steve VanNoy Mr. Jack Seeley Specialty’s Cafe & Bakery Mr. Robert Tepper Bonnie Vansickle Mr. Roy G. Seiber William and Alee Spencer Mr. Keith Terry Ms. Suzanne E. Vaughan Mr. and Mrs. Ralph M. Seifert Mr. and Mrs. Bruce J. Spohler Penny and Mick Thackeray Jill Vedder Mrs. Ann M. Selland Sports Radio KJR Mr. John Thelan Mr. and Mrs. James E. Veitengruber Semiahmoo Resort Mr. Ronald C. Spragg Dalton Thomas Viasat Inc.

32 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Virginia L. Park Family Foundation Brent Willems and Arleen Paulino M. EuGene Barnes and Beverly Ann Barnes Mr. Richard Faulstich Vitalogy Foundation William A. Crosetto Charitable Foundation Patricia M. Bartlett Anton M. and Barbara C. Fleischman George and Laura Jane Viverette William O. and K. Carole Ellison Foundation I. Georgina Bayley Jane B. Folkrod Mr. Gary J. Vogelsberger Charles and Linda Williams Ms. Diana Beckers Bob and Lanie Franza Mrs. Shirley A. Vormsberg-Markov Wilmar Corporation Marc A. Berger Richard and Linda Frasch Mr. Alan Vorwald Kristin Winkle Mrs. Sidonia Berglund Bill and Deryn Fulton David Vos Mr. Jeff Woerner Yahn Bernier and Beth McCaw Larry Gahlhoff Brian and Susan Vowinkel John and Beth Wojick Mr. and Mrs. Harry C. Berryman Ross M. Galvin, M.D. and Patricia G. Galvin Kieran Vye and Christina Karl Nolan and Alexis Wood Sandra Kailes Biller Jane Gerhardt Mr. and Mrs. J. H. Waechter Mrs. Lynn A. Woods Ellen O. Blackstone Roman J. Gerstner and Evelyn R. Gerstner Wagstaff, Inc. Woodson Family Foundation Sandra A. Boeskov James D. and Paula J. Gillmore Gary and Sally Walcott Barbara and Richard Wortley Barbara A. Bonamy Mr. and Mrs. Wayne C. Gott Dr. Stephen A. Wald and Mrs. Joan Wald Roberta W. Wu Christine Borgen Ron and Cathy Grant Janis M. Walsh Brian and Amy Wulfestieg Robert and Sheila Bosanko John and Ann Guerin Wendy G. Walter Kari A. Wuotila Arthur R. Bowers Jack and Dorothy Guinn Mr. Donald T. Wang Mrs. Jean T. Wyckoff Kim Carita Brandt Martha W. Hanscom Sheri L. Ward Wyman Youth Trust Sandra Brentlinger JoAnne Hansen Tiffany Warda Chris Yarrow Carol Hilborn Bridges Mary Alberta Hargrove Andrew and Emily Warden Ms. Tamara S. Young Christine L. and Michael L. Brinton Andy and Carol Harris Shannon Ware Mr. and Mrs. George R. Yount Mary and Geary Britton-Simmons Mr. and Mrs. Robert Harrower, Jr. Elizabeth Warman Dr. Peter Zabback and Elmore G. and Dorcas Brolin Mrs. Mary E. Harvill Vicki and Brian Warner Dr. Kristi Schermerhorn Steve and Gayle Burditt John and Roberta Hayes Cherie R. Warren Mr. Louis G. Zachary, Jr. Mrs. Jennie K. Burwell Hal and Jerry Haynes Ryan Warren Mr. Richard S. Zahniser Mr. and Mrs. Jack and Patty Bush Dr. Frederick and Margaret Hazeltine Washington Federal Savings David A. Zapolsky Ruth Cannon Patricia and Robert D. Heffernan, Jr. Washington State Service BSP John and Nancy Zevenbergen Phillip and Violette Carlson Mr. and Mrs. Severt S. Hegland, Jr. Washington State University Athletics Mr. James L. Ziegler Eleanor E. and Ellen C. Carnwath Ms. Jean S. Heidt Nia and Glen Watabayashi Dr. Ronald A. Zlotoff Douglas A. Case Andrea Helman and Samuel Helman Mr. and Mrs. Charles Waterman Ms. Michelle M. Zuanich Hazel E. Case Mr. and Mrs. David C. Henderson Gary and Karla Waterman Mary E. Cederlund Ralph and Gail Hendrickson Amy Watkins and Michael Reese In FY14, giving to Fred Hutch included 30 Cora Chads Gregory and Anne-Marie Henry Mr. and Mrs. Larry M. Watkins anonymous benefactors. Mylo and Marion Charlston Conrad W. Hewitt Shane Watkins and Alex Deesing Ms. Barbara Chester Michael and Rosemarie Hitt Mr. Joel A. Watson and Ms. Jude Nash Susan L. Christiansen Charlene P. Holt, MD Pat and Ken Weber Legacy Partners in Research Emanuel and Susan Cohen Vivian and Les Houle Mr. Walter R. Weber, Jr. Legacy Partners in Research are individuals Mr. Milton M. Cohen Mr. and Mrs. James W. Howard H. Janet Weiss who support Fred Hutch through a bequest Bob and Sylvia Cook Barbara Howell Lowell Weiss in their will, life income gift, life insurance, Norma M. Corbin Mr. and Mrs. George C. Hudspeth The Weisscomm Group LTD. retirement asset or other planned gifts. Fred Corrado Mr. and Mrs. Paul S. Hunter Weller Orthodontics As Legacy Partners, they create a legacy Mr. Martin J. Costello Mr. and Mrs. James G. Hutton Wells Fargo Community Support Campaign for themselves and their families and Mary Pat Cotty Dr. and Mrs. Gordon L. Imlay Victoria and Edward Wenick play a pivotal role in benefiting future Fred M. Cox David and Gigi Jack Renee and Paul Wesberry generations. Mr. and Mrs. Fenwick J. Crane Douglas L. Jacobs Mr. and Mrs. Mark Wesley Roger and Gloria Crouch Dorothy Doyle Johnson The Westin Excelsior, Rome Charles M. Ackerman and Barb and Art Daniels Mr. Douglas B. Johnson The Westin Maui Resort & Spa Barbara Clanton Ackerman Daryl Drew Charitable Foundation James A. and Holly F. Johnson The Westin Miyako Mr. Donald D. Ackley Joan A. De Bruin Robert P. Johnston The Westin Shanghai Ms. Nancy Agajeenian Laura and Jim DiLella Thomas M. Jones and Judith A. Edwards Westland Distillery Jim S. and June M. Allen Leslie and Deborah Disch Elaine N. Kaald Ms. Kate Whettam Ms. Chelea Alwine Chris and Viki Parrott Dragich Ellen Kam Whitcomb Insurance Agency Jan A. Amen Wayne D. and Susan E. DuPont Mal and June Karfstedt Laura Whitehead Alex and Helen Andersen Lois and Earl Dusenbery Ms. Heidi Kass WhitePages.com Dorothy E. Anderson Peter S. and Sandra W. Dyer Ms. Deborah Kaufman Jack and Jill Whiting Stuart L. and Karen C. Anderson Mr. and Mrs. Robert L. Ecker Brant A. Keeney Bob and Jan Whitsitt Bill and Ruth Anderson Demerise Eddy Frederick and Julianne Klippert Ms. Mary H. Wiese Ms. Victoria Andrews Jerry L. and A. Christine Edwards Nora Korg Wight’s Home & Garden Ardean A. Anvik Alvin and Maija Eerkes Mr. and Mrs. David Kremers Wilcox Farms Inc. James D. and Mary H. McClellan Aronen Mr. and Mrs. Jeffrey B. Ellman, Esq. Larry and Linda LaBolle Robert and Deborah Wilcox Robert and Clodagh Ash Cecil David Enman and Norma J. Enman Mr. William M. and Dr. Geraldine K. Landis Robin Wilcox Alan and C.J. Ashton Katherine S. Eshelman Al and Laura Laney Mr. and Mrs. Eric J. Wiler Dr. Elizabeth Atwood Thomas G. and Kay Nozaki Ewing Mr. and Mrs. Gus Lange Mr. and Mrs. Richard D. Wilhelm N. Faye Bachmeier Colin Faulkner Lolita M. Lanning

33 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

E. Margaret Lawrence Bruce and Karen Richards Penny M. Woods Dr. and Mrs. E. Donnall Thomas Sam and Betty LeBid Foundation Douglass and Lea Richter Sarah Woods Mrs. Barbara Thrasher Roy and Vel Leonard Mr. and Mrs. Joe A. Riedel, Jr. Joseph and Janet Zinn Bonnie and Jim Towne Marjorie J. Levar William A. Ritter Nancy Greenwood Vehrs and Jeff Vehrs Mr. and Mrs. Stephen H. Lindquist William A. (Bill) Roberge Legacy Partners in Research members James and Roberta Weymouth Ralph and Lynda Lipe Claudia Rollins include 190 anonymous benefactors. Lynn Lippert and Sal Jepson Mr. and Mrs. Thomas E. Roth Inner Circle members include 11 June B. and Johnnie I. Louderback Milton and Ruth Rubin anonymous benefactors. Phyllis J. Mandel Mr. Robert H. Rutledge Inner Circle Stephanie D. Mapelli Cynthia and Gerry Salkowski The Inner Circle of the Legacy Partners in Inge Marcus Mary L. Sanderson-Schinman Research is comprised of current and former Committees, Councils and Guilds Mr. and Mrs. Robert J. Margulis Colleen Swift Schafer Fred Hutch faculty, staff and their spouses; Fred Hutchinson Cancer Research Center’s Dr. and Mrs. Herbert A. Marra Patricia L. Schaumberg past and present members of the Board of committees, councils, and guilds are Hank, Fuchsia and Marcia Martin Brent and Susan Schlosstein Trustees, Board of Ambassadors and Senior comprised of volunteers throughout the Joan A. Martin Rosalyn H. Schuknecht Council and their spouses; as well as past Puget Sound area who come together to Mrs. Alma L. McDonald Robert E. Schultz members of the former Foundation Board of raise awareness for Fred Hutch’s mission. Marcia McGreevey-Lewis and Janet Sears Directors and their spouses. It recognizes those Through various activities and events, Robert D. Lewis, M.D. Dorothy L. Shattuck who support Fred Hutch through a bequest these committed volunteers raise critical Douglas G. and Ruth J. McKnight Kenneth and Linda Shefveland in their will, life income gift, life insurance, funds for research and provide services for Elinor K. Menter Pam and Geoff Sheridan retirement asset or other planned gifts. patients and their family members. Pipena Klieros Mercouriadis Jean Simmons June E. Miller Ms. Annette Siversen Steven J. and Lisa M. Anderson Brosio Hamasaki Stein Guild Robert Miller and Marlys Owen-Jones Mr. Eugene G. Sivertson Rich and Leslie Begert Climb to Fight Breast Cancer Committee Verna L. Miller Mrs. Phyllis H. Smith Carl and Renee Behnke Friends of the Hutch Mrs. Anne A. Moldrem Samuel E. and J. Michelle Smith Sally Skinner Behnke Grace Heffernan Arnold Guild Mr. and Mrs. James A. Morrison Joseph T. Smudin Brian R. and Shelley J. Buck Hutch Award Luncheon Joan and Michael Morse Gregory P. Sokolowski William W. and Kathy Lynn Christoffersen Planning Committee Judy Mukai Herba Irene Solstad Mr. and Mrs. John D. Eastham IN for the Hutch Committee David and Pam Mushen Mary Solum Karl and Carol Ege Innovators Network Council Bay Area Mr. and Mrs. Al Neelley Sara Somers Robert N. and Ingrid Lahti Eisenman Innovators Network Council Seattle Ken and Julie O’Brien Mrs. Kathleen P. Spading Barbara Feasey and Bill Bryant Institute for Prostate Cancer Research Mr. and Mrs. Homer Olsen Josephine and Stephen Spear Ms. Linda L. Gainer Community Leaders Council Milton O. and Carole A. Olson James Speckbrock Kenneth J. and Beryl Goodchild Jacob Green Charity Golf Miss Elvi M. Olsson Jenny Rebecca St. Martin Sheri Ray Greaves Classic Committee Sheila and Mel O’Neal Mrs. Caren A. Staley Marcia and Glenn Harrington Live Auction Advisory Board Everett and Dorothy O’Neill Mr. and Mrs. Clyde R. Strauss Debra and Chuck Holland Magnolia Guild Mrs. Jean B. O’Neill Janet Swanson Shelley Kuni Hovind Olympia Guild Stanford E. Opdyke Connie Taylor Deborah E. Kirsner Partners for Survivorship Council Arthur and Viola Oquist Ken and Judy Thomas Lynette A. Klein Premier Chefs Dinner Advisory Board Robert B. Overhus Dick and Ruth Thomassen Reginald S. Koehler III President’s Circle Council Clyde W. Owen Marjorie J. Thorne Judy Kornell Stanley Ozbolt Olive Tice Rose Kowalski Mr. James D. Paddleford and Mr. and Mrs. Michael J. Toennessen Jerrold D. Liebermann and Linda J. Harris Mr. Dent W. Davidson Frances Welguisz Tomasko David A. Little and Michelle A. Gray Mr. and Mrs. Jack G. Parks Mr. and Mrs. David T. Troxel Jeffrey and Ethel Maxwell T. Keith and Janet Patrick Karl R. and Marcile H. Turner Patricia McCowan Grafton Pauls and LaVonne Pauls Mr. and Mrs. Robert E. Vallat Robert D. and Patricia A. McDonald Harry and Katherine Pearce Jean Baur Viereck Neil and Nancy McReynolds Kristian Pearson Joan L. Walston Karen and Jamie Moyer Frederick and Elizabeth Pedersen Jim and Diane Watson Shan and Lee Mullin Mary R. Pelan Steve and Dana Weiner Han and Shawn Nachtrieb Daniel J. Peters Sandra E. Weiss Paul and Carol Neiman George and Cynthia Pierce James P. Welch Martin and Vicki Nelson Julia B. Poduch Nick and Carol Westlund - Dr. Gilbert S. Omenn and Martha A. Darling Mr. Ross Purintun Supporting Organization Guy and Arlene Ott Mr. and Mrs. Robert and Teresa Quigley Richard and Annette Whitaker John H. and Jean B. Rolfe Gus Raaum Marie Legaz Whitley and Michael Whitley Michael B. Rubin Sherry Y. Rae William and Susanna Wiegant Nancy and Michael Ryan Weldin and Jo Ann Read Christopher L. and Ruby D. Wilde Skip and Marilla Satterwhite Liane Redpath-Worlund Carl H. Wittenberg John C. Scibek Thomas L. Reid Ms. Dawn M. Wood Charlene Steinhauer Mrs. Sally Reiquam Lois M. Woodcock and Richard H. Woodcock Gregory Steinhauer

34 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT PRIVATE CONTRIBUTORS FISCAL YEAR 2014

Jane and David Cottrell Henry and Mary Ann James* Lee and Deborah Oatey Coxon Family Foundation The Jean E. Thomson Foundation* Dr. and Mrs. James Olson Crankstart Foundation Mike and Diane Johansson* Carol-Ann O’Mack and John Deininger* Roger and Gloria Crouch* The John and Louise Steegstra John and Billie O’Mack President’s Circle Michael and Judith Crutcher Memorial Fund Pam Oyanagi and Dwayne Myers The President’s Circle is a distinguished group Mark D. Davis The John C. and Karyl Kay Hughes Sujal and Meera Patel of individuals and corporate members who Angeline M. Dick* Foundation* The Paul M. Anderson Foundation share Fred Hutchinson Cancer Research Laura and Jim DiLella Brian Michael Jones and Anna E. Rodzinski Harry Jonathan Pearce* Center’s vision for eliminating cancer and Holly and Eric Dillon* David Jones and Maryanne Tagney* Pete and Wilma Olsen Foundation* related diseases. President’s Circle members Carey and John Dondero Mr. and Mrs. Tim C. Jones Dean and Josephine Petterson make annual gifts of $10,000 or more, C.W. Donovan, Jr. Kalmanovitz Charitable Foundation John B. Piacentini Family* sustaining vital programs and funding The Dr. Maxwell Hurston Family Rich and Karmann Kaplan Paul and Beth Picardo* innovative ideas as they emerge. Reflecting Foundation, Inc. Kaye-Smith* Jay and Harvey Platt Families* gifts received January 1 - December 31, 2013. Lois and Earl+ Dusenbery Keith & Mary Kay McCaw Family Foundation Dean and Gwenn Polik and Valerie Polack* Echo Bay Foundation Keyes Foundation* Mrs. Carolyn G. Ponsford Aisha Ahmad Al Khinji J. Orin and Charlene Edson Jonathan and Pamela Kil Quest for Truth Foundation The Anderson Foundation* Mark Edson* The Klingman Open RACE Charities Foundation Mrs. Dorothy E. Anderson Karl and Carol Ege* Reg and Ann Koehler* James and Sherry Raisbeck Ric and Kaylene Anderson* John and Christine Enslein Harry Korrell James V. Ramsdell, Jr. Mr. and Mrs. Stephen L. Anderson The Eucalyptus Foundation Mike and Debbie Koss* Andrew and Christine Reinland Mr. and Mrs. Eric J. Andrews Chris and Jennifer Falk CAPT M. Thomas and Mrs. Gwenann Kroon Paula and Stephen Reynolds Anduin Foundation Limei Fan and Jay Na Jason M. Kuhn Lee Rhodes and Peter Seligmann Dr. Frederick and Dita Appelbaum* Fortune Family Foundation* Mrs. Frederick Kullman Richard C. Goldstein Private Foundation The Aven Foundation The Foster Foundation Kyoko Kurosawa and Steve Pergam, M.D. Ron and Katie Robertson Mr. Ronald R. Bailey Mr. Robert Frey Sandra L. La Haye* Robinett Family Joe and Karyn Barer Ed and Karen Fritzky Family* Laura A. Landro and Richard E. Salomon Elizabeth W. Robinson and Bill and Sara Barrett Mrs. E. Peter Garrett Rae and Mark Lembersky* John McVickar Robinson Bayley Family Foundation* Michael and Lynn Garvey* The Lewis Greenwood Foundation Mr. Tom Robinson and Ms. Carla Murray Ron and Joan Bayley The Geiger Family Foundation* Jim and Maureen Lico The Rona Jaffe Foundation Carl and Renée Behnke* Roger and Cheryl Gelder Lynn Lippert and Sal Jepson Judith and Kermit Rosen Sally Skinner Behnke*+ George and Margaret McLane Foundation Listwin Family Foundation Milton B. Rubin* David and Joanna Beitel* Mr. and Mrs. Warren A. and Inge M. Geri Benito and Carmen Lopez* John and Nancy Rudolf Barbara Berg and Dan Gottschling Bob and Eileen Gilman Family Mark and Nikki Mahan* Jon and Judy Runstad* Yahn Bernier and Beth McCaw David and Patricia Giuliani and Foundation* David and Nathan Mandelbaum Family* Mr. and Mrs. Michael Sandorffy Yvonne M. Betson Trust – Glaser Foundation David Mann and Ann Thomson Mann* Sarah M. Hughes Foundation Jeff and Ethel Maxwell* Val and Ivene Goemaere* The Marco J. Heidner Foundation Satya and Rao Remala Foundation* Debbie and Jim Bevier Charles Goggio, Jr. Inge Marcus Antoine Schetritt and Amanda Brotman Bezos family The Grainger Foundation Martin–Fabert Foundation Charles and Mary Ann Schroeter Jeff and MacKenzie Bezos Rochelle Greenberg Mattaini Family Foundation Jim and Bet Schuler* Binder Foundation Mark Groudine and Cynthia Putnam* John and Liz McAdam* Bill and Marlene Semple* Bishop Family Legacy Foundation Nancy Gudmundson Kevin and Sarah McCain The Sheri and Les Biller Family Foundation Cathy Boshaw and Doug Edlund* George and Linda Guillot Mr. Tim R. McCulloch Craig Shrontz and Lynn Ristig James Boshaw Jeff and Julie Guillot Rob and Teddy McGregor Frank Shrontz* Phillip and Karla Boshaw Donald Guthrie and Candace Tkachuck* Matt and Carol McIlwain Clay Siegall Elisabeth Bottler* Erik and Susan Hansen* Mrs. Charlotte M. Merritt Mark and Brenda Simons Mr. and Mrs. Erik P. Breivik* John and Suzanne Hansen Norman and Suzanne Metcalfe Jim and Jan Sinegal* Bruce McDonnell Golf Memorial Classic John J. and Katherine A. Harnish Richard and Kathryn Miyauchi Dr. and Mrs. Robert M. Sinskey Shari and Frederick Burns* Deborah and Eric Haug Mo-dazz for the Arts Phil and Sally Smart, Jr. Gary and Catherine Bylund* Pete and Leslie Magid Higgins* Michael Moritz and Harriet Heyman Doug and Marilyn Southern* Canary Foundation Iva and Lawrence Hirsch Joan Morse and Dean Hachamovitch* Tom and Diane St. John* Mark and Lisa Caputo Jerick R. Hoffer Bud Mount Howard and Cynthia Steinberg Carlson Family Foundation* Dr. and Mrs. Eric C. Holland Shan and Lee Mullin* John and Sherry Stilin Mrs. Cecelia C. Carr* Frank and Lisa Holland Multiple Myeloma Opportunities for Dr. Rainer Storb and Charles B. See Foundation* Peter and Peggy Horvitz* Research & Education Dr. Beverly Torok-Storb Brad and Judy Chase* Mr. Bradley J. Horwitz National Breast Cancer Foundation, Inc. Ambassador Cynthia Stroum* Mr. Eric W. Christenson Mr. Norman E. Hubbard Paul and Carol Neiman Arthur and Lori Sullivan Mr. Joe Clark The Hutchinson Family* Robert E. and Amy T. Neiman Suskin Foundation Mike and Corry Clayville Hyundai Hope on Wheels Robert Nelsen and Ellyn Hennecke* The Swanson Family Jordan and Katie Corey The Ildhuso Family* Peter and Sheryl Neupert Ms. Myra H. Tanita Larry and Amy Corey Nea Lynn Ireland Charles and Eleanor Nolan Mrs. Dorothy E. Thomas* Barbara Cosgrove and Frank Yandrasits J. Orin Edson Foundation The Norcliffe Foundation Mikal and Lynn Thomsen* Virginia Cosgrove Jacob Green Charity Golf Classic Roger F. Nyhus Barbara Thrasher and Rick Koffey

35 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT Bonnie and Jim Towne* Tana L. Chmieleski Melissa and Shawn Herron Tom and Margo Van Halm* Ba Kang and Xiangyu Chu Mr. and Mrs. Troy Hickey * Van Sloun Foundation* Mary C. Clare and Ryan J. Hall Brent and Dulcy Hixson Vijay and Sita Vashee Simon Clarke and Alice Burden Jerick R. Hoffer Farid and Asha Virani Innovators Network Members Andrew and Juli Cook Scott and Joanna Holden Mrs. Vilma F. Vojta Innovators Network (IN) is the next Greg and Erin Coomer Sarah C. Hopkins and Anirudh Bansal Dr. Lawrence G. Votta generation of community leaders who Jordan and Katie Corey Mr. and Mrs. John H. Howard Vs. Cancer Foundation share a commitment to funding innovative, Heather Craig Desert Horse-Grant Doug and Maggie Walker* life-saving research at Fred Hutch. Geared Ryan and Elise Crumpacker Tamar Huberman Tom and Jeanne Walker toward those 45 and under, IN members Jeffrey and Lorine Cummings Trevor and Donabelle Huffmaster Mr. Joseph N. Walter and make annual contributions of $1,000 or Brian and Elise Cunningham Jim and Heather Hughes Ms. Kathy L. Mares more to support high priority projects that Gregory and Karis DeVore Shannon and Troy Hull Bruce and Peggy Wanta accelerate the pace of promising research. Charles Dorner Olivier and Catherine Humbert * Drs. Edus and Linda Warren Reflecting gifts received January 1 - Alexander and Hilary Doroski Mark and Mollie Huppert Elizabeth Wayner December 31, 2013. Traci L. Drake and Ann Torres Scott and Amy Hutchinson * Bryan and Pamela Weeks Amy L. Dyers Denise and Brian Ivie Nancy Weintraub Jeremy and Larisa Affeldt * Jeffrey and Karen Edwards Angela and Fred Jackson Mr. and Mrs. James L. Wellinghoff Aisha Ahmad Al Khinji John and Caroline Edwards Mr. Dana Jacobs Wissner-Slivka Foundation Stephanie Alexander and Michael Wilson Tracey and Mike Elfstrom Bo Janes and Derek Eisel Woldenberg Foundation Curt and Ashley Anderson Dr. Bruce and Veronica Erhart Kurt and Clair Jensen Ann P. Wyckoff Tyler R. Andrews Kerry and Michael Fagelman Allen and Carleigh Johnson * The Yeck Family Sophia L. Arain Adam and Shannon Fain Chris and Jenny Johnson Melinda Yount Jill Argo John and Margaret Fiala Andrea Jones * John and Nancy Zevenbergen Geoff and Catherine Austin Alison Fields Tyler and Anna Jones Joseph and Janet Zinn* Lindsey Avery Scott and Amy Finholm * Jeremy and Wendy Kelly Barry and Amber Zito Sarah C. Avery Jens Fischer and Shaheed Khan Eric Bahna Susanne Wagner-Fischer Niraj Khanchandani Kirk D. Baisch Mr. and Mrs. Matthew T. Fitch Mr. and Mrs. Eldon W. Kiel Corporate Members of the Chris and Keri Balmer * Mark and Jayme Freeborn Benjamin F. Kilgore President’s Circle Richard and Joanne Barber Jayne and Eric Freeman Susan Kim Amgen Carrie M. Barham Lisa Fritzky Tonya and Darryl King athenahealth Erin and Ethan Bernau Ryan L. Fritzky and Susie M. Fritzky Kyle Kingma Bayley Construction Nick Berry Kyle and Katrina Fukuchi Leigh Kinnish Celgene Ken and Shiori Betzler Mark and Annelise Gaaserud Lauren Kisser Chateau Retirement Communities Sue Biggins Phil and Lisa Gafken Brian and Melynda Kite Costco Wholesale Casey A. Biltucci Sheri and Omri Gazitt Lynette and David Klingeman Esterline Technologies Corporation Chris and John Brandenfels Nandita and Jochem Geerdink Jeffrey and Michelle Knoll F5 Networks, Inc. Aaron Bregel * Michelle Geiger and Jon Ashley * Harry Korrell glassybaby Sally and Michael Brick Alan and Jeanine Gilchrest Kyoko Kurosawa and Steve Pergam, M.D. Histogenetics Bill Brooks, Jr. Bradley and Theresa Glaberson Richard Kyle and Kara Matthew * Kibble & Prentice, A USI Company Craig Baylor Brooks and Tim and Jennifer Goggin Molly Lallemand Kinzer Real Estate Services Courtney Suzanne Clarke Peter and Beth Golde Jeffrey and Lisa Lanctot Matson Michele Brooks Miss Kelley E. Goldmanis Amy and Aaron Lavin Michael’s Toyota of Bellevue Steve and Jennifer Brooks * Benjamin Gonnet * Nancy J. Lee Perkins Coie LLP Bradley and Amy Brotherton Douglas Gordon Sylvia Lee and Glenn Kelman Premera Blue Cross Bryan and Joy Brown Benton and Caroline Gray Daniel A. Lelewski Presage Biosciences Ivan Brugiolo Dale G. Gray Kimberly and Thomas Lengle Safeway Inc. Bryce and Brooke Buri Jennifer and Bryan Grusz Jeremy and Stefanie Lince Turner Construction Company* Lance and Holly Burkett Pooja Gupta Clark and Lori Lindsay University Mechanical Contractors, Inc. Lauren L. Burman Susanne and Scott Guthrie * Peter and Sarah Lindsay Winebow, Inc. Matt and Alli Burton Jessica Michel Hagan and Curtis Hagan Matt and Elisha Logue * ZGF Architects LLP* Carl and Angela Bush Justin Hagood Jeffrey and Jennifer Lounsberry Gary Caldwell Jeff Hardie and Laurie Saito * Michelle S. Ludwig President’s Circle benefactors include Erica and Jose Campos Jennifer Harnish Elizabeth and Brian Lund * 13 anonymous donors. Jen Caparas John and Elena Harnish Dennis Ma and Vannessa Nhan Mark and Lisa Caputo * Walter and Angela Harp Greta Ma Rick and Amber Cassidy Greg Harrell-Edge Thaddeus O. Mallory, Jr. and Lisa Mallory Shu-I Chang Kevin and Bobbi Harrison Lauren and Justin Martin Steven and Michelle Chattin Alexandra and Adam Hedin Erick Matsen Kelly Cheeseman Jeffrey and Shelly Heier * Ryan and Sara Maxwell * Donald L. Chi Todd and Stephanie Henderson * Tod and Christa McBryan * Lisa Chiang * Justin and Catherine Hendrickson Kevin and Sarah McCain

36 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT Ryan McCallen Beth and Chris Schmaltz Seattle Cancer Care Alliance Aerojet Michael D. McCann Daniel R. Schroeder The Seattle Cancer Care Alliance (SCCA) Alexander C. and Tillie S. Mark McCasey Matthew and Kathryn Sentena unites the world-class treatment and Speyer Foundation Jon and Caren McCormack Todd and Ashley Sevier research activities of Fred Hutchinson Mr. and Mrs. Douglas M. Allan Alyson and Durham Mccormick Omar and Lora Shahine Cancer Research Center, UW Medicine Dr. Alul, MD, InFocus Eye Care Michelle L. McCormick Richard J. Shanahan III and Seattle Children’s. In fiscal year 2014, Mrs. Tamara Anderson Ian and McFarland Mark and Susan Shapiro * over 2,896 benefactors contributed or Dr. Frederick and Dita Appelbaum Michael and Heather McKay Kristin and Aaron Shaw pledged $2,090,845 million to the SCCA George W. Bacon Niki McKay and Dave Jungck Jason J. Shinn to support efforts to provide premier, Karen and Robert Bakemeier Bill and Nicole McNichols Kurt and Kylee Shintaffer * patient-focused care and access to Baker Manufacturing, Inc. Cole and Kathryn Meckle Isaac and Nicole Sine groundbreaking clinical research to Mr. Randy Bartsch Yazmin Mehdi and Liam Lavery John D. Sisler, Jr. patients from around the world. Dr. Pamela Becker and all nurses at SCCA Rob and Rachelle Meredith Jennifer Sizemore and William Hawn Benevity Social Ventures Inc. Michael and Lisa Miller Kelly E. Smith $100,000 - $249,999 Linda and George Berkman Kelly and Martin Minnaar Joseph and Jennifer Sprague AEG Live Mr. and Mrs. Lynwood Bishop Ulrich Mueller and Diana Ensenat * Jessica D. Stewart The Madhouse Project Betty Bottler Gary Mutchler Jason and Wendy Stively Swim Across America Steve and Steph Briscombe Katharine and Stephen Newman Sonya Stottlemyre Dr. S. Lori Brown and Mr. Chris Green Dr. Lisa Nguyen Luke Stroud and Dave Siegfried $50,000 -$99,999 Mrs. Desiree Bruce Todd and Marci Nicholson Brian and Gina Summers Muckleshoot Casino Dr. David Byrd Christopher and Kathleen Nielsen Kyle and Emi Suzuki Mr. John Caraher Trevor and Marci Nolan Michael Swafford * $25,000 -$49,999 Mr. and Mrs. Jeffrey D. Carnevali Fred Northup, Jr. and Ashley Northup Brandon and Sami Sweeney Drive Fore the Cure Northwest Foundation Dr. and Mrs. Mike Casey, MD David Notario and Latife Lacin Scott Swerland Rat City Rollergirls Mike and Karen Chadduck Dr. Dodi and Rachael Nov Kathryn A. Sweyer and Chris Berta Manisha and Devindra Chainani Roger F. Nyhus Shane and Alexis Tackett $10,000 - $24,999 Mac and Linda Cheever Tim Oerting Sarah and Casey Tallon Carl and Renée Behnke Ms. May Lee Chung Dr. Yince and Ms. Kathyryn Oliver Lyle and Virginia Tenpenny Maria Burke Mr. Mark Collins Kaven and Gary Oltman Alison Tierney Michael and Judith Crutcher The Columbia Foundation Michael Orbino Andrew and Shana Tischaefer Expedia Inc. Compendium Jesse and Jennifer Ottele Brett Tocco Jacobs Johnson Foundation Mr. and Mrs. Bryan Conner Catherine L. Peichel and Steve Froggett Andrea Towlerton Perkins Coie LLP The Considine Family Michael and Jennifer Peters Caroline and Joshua Traube Safeway Inc. Dr. Shannon Corbin and Tom and Katherine Peters Supriya Uchil The Seattle Storm Mr. Jonathan M. Tingstad Kemp C. Peterson Luis and Colette Ulloa * Seattle Symphony The Crowded Corner Christopher and Christiane Pitts Dustin and Elizabeth Van Wyck Jim and Jan Sinegal Cutting Technology, Inc. William and Ricca Poll Danielle and Steve VanNoy Sterling Realty Organization Danner Corporation Darin Postma David Vos Mr. and Mrs. Michael Truax Howard and Sarah Date Lauren R. Powell Brian and Susan Vowinkel University of Washington Sylvia M. Davids Nicole and Michael Pratapas Vs. Cancer Foundation Delman Family Trust Elizabeth Prescott and Daniel Stetson * Andrew and Emily Warden * $5,000 - $9,999 Elizabeth and Steven Deutsch Eric Prock and Tracy Sullivan Prock Shannon Ware Mr. Paul G. Allen Employees Community Fund of Robert and Victoria Quiles * Ryan Warren Kirsten Anderson and Robbie Lowery The Boeing Company Patrick B. Reddy Amy Watkins and Michael Reese Columbia Athletic Clubs Ms. Arlene Engelstad April Reitan Doug Watkins and Dona Sarkar glassybaby Mr. and Mrs. Robert C. and Vera Ellen Fahl Srilata D. Remala Shane Watkins and Alex Deesing Mr. Justin Hillenbrand Janice L. Ferguson Carrie D. Rhodes Eric and Catherine Wedge Mrs. Gretchen S. Hull Fortune Family Foundation Tiffany and Casey Ribera Lowell Weiss and Sara Finkelstein Mr. and Mrs. Dennis W. Kohloff Deborah and Mark Gentzen Maurice Rice Victoria and Edward Wenick Magic Toyota Mr. and Mrs. Ralph and Bea Gilfilen Terry and Benton Richardson Renee and Paul Wesberry * Bob Miller The Giustina Foundation Craig and Jessica Robinson * Eric and Daria Whettam Mr. Greg Miller GMS Metal Works Inc Jeff Rodgers and Deborah Barge Rodgers * Ms. Kate Whettam Bud Mount Greenbaum Home Furnishings Brian J. Rogers Nolan and Alexis Wood Kenneth and Candice Overman Ms. Cheryl B. Grimm Mimi Rosen and Nathan Goldberg Brian and Amy Wulfestieg PAC-12 Conference Mr. Steve Haag Sheri and Andrew Rosen Kari A. Wuotila Pacific Northwest Ballet Mark and Dana Hagenbaugh Brian and Deborah Rowe Megan Young Seattle Seahawks Mr. and Mrs. Jon K. Hahn Calvin and Lauren Rowland Toyota Dealer Match Program Matt and Julia Hanrahan Andrew Ryder Innovators Network benefactors include Vulcan Inc. Mit and Maureen Harlan Sara Sage two anonymous donors. Brian and Kristin Hartnett Justine and Rob Sands $1,000 - $4,999 Mr. and Mrs. Russell P. Herwig David and Lisa Schilling *Charter members Dave and Kim Ackerson Ms. Karyn R. Honigsfeld Gena and Alex Schirer * The Adams Family Mr. Robert Hoppa and Ms. Sandy Shaw

37 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT Mr. Norman E. Hubbard Ronald McDonald House Charities of Mr. Tom Hull Western Washington & Alaska Mr. Robert E. Jagels Mr. Bruno A. Rudolf The John and Louise Steegstra Jon and Judy Runstad Memorial Fund Safeco Insurance Ms. Jonelle M.C. Johnson Mrs. Helen Saito The Kemper Freeman Foundation Mr. Van M. Sarver Kent School District #415 Ms. Kelly D. Saunders Stacie Lyn Kentop Mr. and Mrs. Kevin L. Schemm Carol J. Kibble School Employees Credit Union Mr. Edward B. Kibble of Washington Kitsap Co. Deputy Sheriff’s Guild Ms. Virginia L. Schwedler Kitsap Destruction Derby Association Seattle Children’s Theater Mr. and Mrs. Ralph R. Krueger Mr. and Mrs. Howard L. Seelig Kvichak Marine Industries, Inc. Mr. and Mrs. Norman W. Sellman L&L Exhibition Management, Inc Mr. Tony Sepanski and Mrs. Ann L. Phillips Mrs. Wilma M. Laity Mr. Shahryar Shahrivar Dr. and Mrs. Edward C. Last Mr. and Mrs. Martin R. Shelley Mr. and Mrs. Kenneth D. Lawson Mrs. Patricia L. Shinstrom Janet and Tom Leeds Mr. and Mrs. Eugene Skiffington Mr. Lester M. LeRoss Mr. and Mrs. Burton Smith The Lester and Bernice Smith Foundation Karen Marcotte Solimano and Lillie and Cohoe James P. Solimano Mr. and Mrs. Harry A. Linker Ms. Johnese M. Spisso and Mr. Eric Lippke Mr. Ross Hartling Ms. Kristine A. Logan Mr. and Mrs. Donald J. Stabbert The Lookout Foundation, Inc. Dr. and Mrs. F. Bruder Stapleton Low Pressure Promotions, LLC Dr. Diane R. Staves Mr. and Mrs. Jeffrey A. Lubetkin Mr. Forrest M. Stewart Rob MacAulay and Keri Ellison Timothy C. Sullivan Magic Nissan of Everett Ms. Myra H. Tanita Ms. and Mr. Lisa M. Magnusson Townsend Bay Soap Company Mr. and Mrs. Jeremy E. Mattox True Fabrications Inc. Mr. and Mrs. Richard B. McCune Ultrasonic Cutting, Inc. Mrs. Kimberly A. McNally United Way of King County Meridian Valley Country Club Mr. and Mrs. Frank W. Vandermeer Women’s Division VitalSource Staffing, LLC Mrs. Cheryl S. Meyer Mr. Jack Vu Mr. Bob Middelburg Washington State Employee Mr. and Mrs. Tom Milios Combined Fund Drive Mrs. Bliss N. Miller Will Weinstein and Laurie Antonellis Mr. and Mrs. John H. Mills Mr. William E. Whitaker Wendy C. Mitsuyama Mr. and Mrs. Barry A. Willis Shan and Lee Mullin Ms. Margaret Wizenberg National Christian Foundation Woodland Park Zoo Society National Comprehensive Cancer Mr. Richard C. Yarmuth Network, Inc. Mr. and Mrs. Jeffery Zimmerman Mr. and Mrs. Michael Newsome Ms. Emily Ngo In FY14, giving to the SCCA included 3 Cynthia and Thomas Ostermann anonymous benefactors. Pacific Crest Savings Bank Ms. Jane Palmer Lynn C. Patten Performance Wheel Drs. Carl and Jeannette Pergam Mr. Tony Perucca Mr. William Poole and Ms. Janet Levinger Mr. and Mrs. Jay R. Portnoy Precor, Inc. Brooks and Suzanne Ragen Mr. and Mrs. Robert R. Richardson Dr. Sharon Romm

38 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT FINANCIAL SUMMARY

FRED HUTCHINSON CANCER RESEARCH CENTER FISCAL YEAR 2014

OPERATING REVENUES FISCAL YEAR 2014

Research Grants and Contracts $313,692,000 (72%)

Other Income 52,453,000 (12%)

Net Contributions 37,980,000 (9%)

Investment Income 31,385,000 (7%)

OPERATING EXPENSES FISCAL YEAR 2014

Program Services – Research $323,844,000 (77%)

Facilities and Administration 88,381,000 (21%)

Fundraising 8,257,000 (2%)

SOURCES OF CONTRIBUTIONS FISCAL YEAR 2014

Major Gifts 47%

Planned Giving 13%

Corporate and Foundation Relations 10%

Annual Giving 10%

Gifts of $10K - $49K 7%

Obliteride 7%

Events 6%

Fiscal year 2014 numbers are preliminary and unaudited Rounded to the nearest $1,000

39 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT THE POWER OF PHILANTHROPY

FEDERAL SUPPORT IS SHRINKING The National Institutes of Health budget for U.S. biomedical research decreased 8.7% over the past three fiscal years (a 13.2% drop after adjusting for inflation).

FRED HUTCH FEELS THE IMPACT Fred Hutch received $25.3 million less in NIH grants (approximately 7.4% reduction) in FY14 than in FY12.

YOUR DONATIONS HELP CLO SE THE GAP Fred Hutch benefactors contributed $16.5 million more in FY14 than in FY12 (a 37.4% increase).

OUR COMMUNITY’S REACH

IN SEATTLE AND BEYOND

Fred Hutch employees 2,697 Volunteers 1,500 Study participants 25,000 Donors 31,202

ONLINE AND SOCIAL

Facebook likes 13,700 Twitter followers 10,600 Website visitors per year 1.15 million

40 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT FRED HUTCHINSON CANCER RESEARCH CENTER

BOARDS FISCAL YEAR 2014

BOARD OF TRUSTEES BOARD OF AMBASSADORS

Paula Reynolds, Chair Carl Behnke, Co-Chair Jim Sinegal, Vice Chair Bonnie Towne, Co-Chair Doug Walker, Immediate Past Chair Karl Ege, Treasurer Ronald Berenson, M.D. Ric Anderson, Secretary Kathryn Harris Peter Horvitz Holly Dillon John Hutchinson Terry Gillespie Stuart Hutchinson, M.D. Steve Graham Karmann Kaplan Governor Christine Gregoire Rich Kaplan Henry James Yvonne Lamey Rick Koffey Jeff Maxwell Rich McCune Joan Morse Matt McIlwain Nancy Pellegrino Norm Metcalfe Charlotte Reed Bob Nelsen Barbara Thrasher Peter Neupert Mary Wiese Charlie Nolan, M.D. Vijay Vashee

LEADERSHIP

Mark Groudine, M.D., Ph.D. Tony Bozzuti Doug Shaeffer ANNUAL REPORT Acting President and Director Vice President and Vice President Published by the Chief Information Officer General Counsel Communications & Marketing Department Frederick R. Appelbaum, M.D. Deputy Director and Shane Hollett Jennifer Sizemore Fred Hutchinson Cancer Research Center Executive Vice President Interim Executive Director Vice President Mail Stop J5-200 Development Communications & Marketing PO Box 19024 Myra Tanita Seattle, WA 98109-1024 Executive Vice President and Randy Main Paul Woloshin, Ph.D. 206.667.4399 Chief Operating Officer Vice President and Vice President fredhutch.org/annualreport Chief Financial Officer Shared Resources Garnet Anderson, Ph.D. © 2014 Fred Hutchinson Cancer Research Center Senior Vice President Han Nachtrieb Director, Public Health Sciences Division Vice President Editor Human Resources Andrea Detter Jonathan Cooper, Ph.D. Senior Vice President Scott Rusch Project Manager Director, Basic Sciences Division Vice President Carla Blakeman Facilities and Operations Designers Eric Holland, M.D., Ph.D. Kim Westphal Senior Vice President Jim Woolace Director, Human Biology Division Writers Julie McElrath, M.D., Ph.D. Deborah Bach Senior Vice President Linda Dahlstrom Director, Vaccine and Infectious Mary Engel Disease Division Susan Keown Diane Mapes Dr. Sabrina Richards Dr. Rachel Tompa

Developers/Multimedia Carla Blakeman Sean Downing Bo Jungmayer

Photographers Robert Hood Bo Jungmayer

41 FRED HUTCHINSON CANCER RESEARCH CENTER | 2014 ANNUAL REPORT fredhutch.org

Mail Stop J5-200, PO Box 19024, Seattle, WA 98109-1024 206.667.4399 1.800.279.1618