Volume 23, Number 3, 2018 HEART NEWS

AND VIEWS www.ishrworld.org ISHR International Society for Heart Research THE NEWS BULLETIN OF THEEuropean INTERNATIONAL Section SOCIETY FOR HEART RESEARCH

MENDOZA, PERTH, ECI-NAS AUSTRALIA Committee April, 2017 August, 2017 2017 – 2019 13 6 12

50TH ANNIVERSARY OF ISHR In this Issue: HISTORY OF THE ISHR 1967 – 1998 ■ 50th Anniversary of the ISHR. . 1 ■ President’s Letter ...... 5 ■ Report on the Australasian Section Meeting...... 6 ■ Report on ISHR-ES/SERVIER Research Fellowship 2014. . . 8 ■ Meetings Calendar...... 11 ■ ECI Activities...... 12 ■ Report on Latin American Section Meeting...... 13

Celebrations at the 25th Anniversary of the ISHR at a dinner meeting in Kobe, Japan, 1992. Front table: Drs. Winifred Nayler, Lionel Opie, Jutta Schaper, Naranjan Dhalla (author of this article) and David Hearse. Back table: Dr. Bohuslav Ostadal, Dr. Makoto Nagano and Dr. and Mrs. Robert Jennings. he International Society for Heart Research (ISHR) was started in Boston in 1967 as the International Study Group for Research in Cardiac Metabolism T(Study Group). The Study Group was founded by Dr Eӧrs Bajusz (Boston) in collaboration with Drs Richard Bing (Pasadena) and George Rona (Montreal), and was registered with appropriate by-laws and logo (Fig. 1A) as a Non-Profit Organization in the Commonwealth of Massachusetts in 1967. The objectives of this organization were to: (i) promote research in cardiac metabolism, structure and func- tion; (ii) disseminate knowledge in cardiac sciences; and (iii) foster research collabo- rations through publications, conferences and other media. Several experimental and investigative cardiologists from USA and Europe were invited to become Founding Members effective 1968 (Table 1). While Dr Bajusz assumed the office of Director of http://ees.elsevier.com/jmcc/default.asp International Affairs, Dr Bing agreed to serve as President, Dr Edward Sonnenblick for online submission of manuscripts

1 THE NEWS BULLETIN OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH

Table 1. Founding Members of the International Study Group for Research Press, Baltimore to publish the proceed- in Cardiac Metabolism (1968). ings of different Congresses of the Study 1. Abelman WH, Boston, USA 25. Kubler W, Dusseldorf, Germany Group in the form of a series of books, 2. Bajusz E, Boston, USA 26. Lockner A, Bellville, South Africa “Recent Advances in Studies on Cardiac 3. Baroldi G, Milan, USA 27. Moret P, Geneva, Switzerland Structure and Metabolism”, edited by Dr 4. Bing RJ, Pasadena, USA 28. Opie LH, London, England Bajusz in collaboration with Dr Rona. 5. Bloor CM, La Jolla, USA 29. Olson RE, St. Louis, USA 6. Brachfeld N, New York, USA 30. Ostadal B, Prague, Czechoslovakia The Bajusz/Bing/Rona team next iden- 7. Brink AJ, Bellville, South Africa 31. Poupa O, Prague, Czechoslovakia tified appropriate individuals for 2-year 8. Buja LM, Bethesda, USA 32. Raab W, Burlington, USA appointments as Council Members to govern the organization (Table 3). 9. Burch GE, New Orleans, USA 33. Regan TJ, Newark, USA Furthermore, Dr Bajusz persuaded his 10. Cantin M, Montreal, Canada 34. Reuter H, Bern, Switzerland personal friends, namely, Drs G. Baroldi 11. Carafoli E, Zurich, Switzerland 35. Roberts WC, Bethesda, USA (Milan), A.J. Brink (Bellville) and W. 12. Carmeliet E, Leuven, Belgium 36. Rona G, Montreal, Canada Raab (Burlington), to organize and chair 13. Caulfield J, Boston, USA 37. Schwartz A, Houston, USA International Congresses in Italy, USA 14. Dhalla NS, Winnipeg, Canada 38. Scholoz H, Maine, Germany and South Africa in 1969, 1970 and 1971, 15. Ferrans VJ, Bethesda, USA 39. Schreiber SS, New York, USA respectively. From 1971 to 1976, the 16. Fleckenstein A, Freiburg, Germany 40. Selye H, Montreal, Canada Study Group underwent several organi- 17. Goodwin JF, London, England 41. Shipp JC, Gainsville, USA zational alterations, including expansion 18. Gudbjarnason S, Reykjavik, Iceland 42. Sonnenblick E, Boston, USA of its scope and activities and promotion 19. Harris P, London, England 43. Sperelakis N, Charlottesville, USA of worldwide membership. Thus in 1976 20. Hatt PY, Paris, France 44. Trautwein W, Hamburg, Germany the name of the Study Group was changed 21. Hess ML, Richmond, USA 45. Vassort G, Orsay, France to the International Society for Heart 22. Jennings RB, Chicago, USA 46. Williamson JR, Philadelphia, USA Research (ISHR) at the 8th International Congress in Tokyo to better reflect the 23. Katz AM, New York, USA 47. Wollenberger A, Berlin-Buch, Germany diverse expertise of its membership. New 24. Krause EG, Berlin-Buch, Germany 48. Zak R, Chicago, USA by-laws were developed by Dr Robert B. Table 2. Officials of the Study Group (1968-1976). Jennings (Durham) to govern the ISHR 1968-1970 President – Richard Bing (Pasadena), Vice President – Edward Sonnenblick (Boston), and define the relationship between- dif Secretary – Arnold Schwartz (Houston), Director of International Affairs – Drs Bajusz (Boston) ferent international Sections (Jennings 1970-1972 President – Richard Bing (Pasadena), Vice President – Edward Sonnenblick (Boston), RB. Heart News and Views, 18:3, 2011). Secretary – Arnold Schwartz (Houston), Director of International Affairs – Drs Bajusz (Boston) These by-laws were approved in 1980 at 1972-1973 President – Richard Bing (Pasadena), Secretary General – Naranjan Dhalla (Winnipeg), Treasurer – James Caulfield (Boston), Director of International Affairs – Drs Bajusz (Boston) the International Congress in Moscow 1973-1976 President – Albert Wollenberger (Berlin-Buch), Secretary General – Naranjan Dhalla (Winnipeg), (Journal of Molecular and Cellular Treasurer – James Caulfield (Boston), Honorary Life President – Richard Bing (Pasadena) Cardiology 24: 1203-1210, 1992), and ISHR was registered and incorporated (Boston) as Vice-President and Dr Arnold Dr Eӧrs Bajusz (Fig. 1B) was a highly as a Non-Profit Organization under the Schwartz (Houston; later Cincinnati) as talented individual with clear vision, great Canadian Incorporation Act in 1982. The Secretary (Table 2). The Study Group intellect and exceptional organizational current ISHR logo (Fig. 1C), proposed was started because most of the research skills. In 1968, he persuaded a German by Dr Jutta Schaper (Bad Nauheim), was work presented at both the American pharmaceutical company to host the first adopted at the International Congress in and European cardiology meetings was International Congress of the Study Group Prague in 1995. concerned with clinical cardiovascular in the beautiful city of Dubrovnik (former medicine with little emphasis on basic Yugoslavia). In the same year, he started Development of Different Sections cardiac research. The formation of the discussions with Academic Press, London While preparations for the 1974 Study Group for promoting the relation- to publish the Journal of Molecular and International Congress held in Quebec City, ship between experimental and clinical Cellular Cardiology (JMCC) and invited Canada were in progress, it was decided to cardiologists was the result of numerous Drs Richard Bing and Lionel Opie to serve hold all future Congresses every two years discussions among cardiovascular investi- as its editors; the first issue of this journal instead of annually. This was done to accom- gators and careful planning by Dr Bajusz was published in April of 1970. In addi- modate the proposal of some European over a three year period. tion, in 1972 he contracted University Park members, who wished to set up a European

2 VOLUME 23, NUMBER 3, 2018

Table 3. Council Members of the Study Group (1968-1976)

1968-1970 Abelman WH (Boston), Baroldi G (Milan), Brink AJ (Bellville), Burch G (New Orleans), Caulfield J (Boston), Hatt PY (Paris), Opie LH (London), Rona G (Montreal) 1970-1972 Abelman WH (Boston), Baroldi G (Milan), Brachfeld N (New York), Brink AJ (Bellville), Burch G (New Orleans), Caulfield J (Boston), Dhalla NS (Winnipeg), Ferrans V (Bethesda), Hatt PY (Paris), Morat P (Geneva), Opie LH (Cape Town), Poupa O (Prague), Raab W (Burlington), Rona G (Montreal), Schreiber SS (New York) 1972-1973 Baroldi G (Milan), Brachfeld N (New York), Brink AJ (Bellville), Ferrans V (Bethesda), Gudbjarnason S (Reykjavik), Hatt PY (Paris), Moret P (Geneva), Olson RE (St. Louis), Opie LH (Cape Town), Poupa O (Prague), Rona G (Montreal), Schreiber SS (New York), Schwartz A (Houston), Sonnenblick E (Boston), Wollenberger A (Berlin-Buch) 1973-1976 Baroldi G (Milan), Brink AJ (Bellville), Gudbjarnason S (Reykjavik), Harris P (London), Hatt PY (Paris), Kolbel F (Prague), Moret P (Geneva), Ojiambo HP (Nairobi), Olson RE (St. Louis), Opie LH (Cape Town), Poupa O (Goteberg), Rona G (Montreal), Schroeder H (Stutgaart), Schwartz A (Houston), Sonnenblick E (Boston)

Table 4. Establishment of the Sections of the Study Group/ISHR (1973-1984) Fig 1: A – Logo of the International Study 1973 European Section – Peter Harris (Secretary) Group in Cardiac Metabolism (1967-1976) and the International Society for Heart Research 1974 American Section – Richard Bing (President); Naranjan Dhalla (Exec Sec) (1976-1995). B – Dr. Eӧrs Bajusz, who 1974 Japanese Section – Tochio Koboyashi (President); Yoshio Ito (Secretary) founded the Study Group. C – New Logo of 1976 Indian Section – Mohamed Tajuddin (President); Balraj Bhatia (Secretary) the International Society for Heart Research (ISHR) adopted in 1995. 1976 Soviet Section* – E.I. Chazov (President); Vladmir Smirnov (Secretary) 1978 Australasian Section – Winifred Nayler (President); Peter McLennan (Secretary) Section of the Study Group to hold meet- 1981 East European Subsection* – Laszlo Szekeres (Secretary) ings in Europe in the alternate years. This 1983 Latin American Section – Horacio Cinglolani (President); Alicia Mattiazzi (Secretary) proposal was approved by the Council and ratified at the General Assembly in Freiburg 1984 Chinese Section – Chide Han (President); S.G. Chen (Secretary) * Due to political reasons, membership from this Section and Subsection was merged into the European in 1973. The Executive Committee, includ- Section effective 1995. ing Drs Bing, Wollenberger, Rona and Dhalla, continued to promote membership ferences, and thus made a unique impact on orations; (iv) holding Council meetings to and cardiovascular activities in other parts the participants. The attendance at the first discuss the past, present and future opera- of the world, leading to the formation of four Congresses at Dubrovnik, Gargnano, tions of the organization, and (v) convening the American, Japanese, Indian, Soviet Stowe and Tiervlei varied between 40 to the General Assembly for the ratification of and Australasian Sections between 1973 150 whereas the Prague Congress registered elections and other decisions of the Council and 1978 (Table 4). When the name of the more than 1,200 participants. The increased by the membership at large. Each Congress Study Group changed to ISHR in 1976, attendance over time at these Congresses engendered its own excitement and was all the Sections of the Study Group were reflected the growth and popularity of the a venue for developing long lasting rela- renamed as ISHR-Sections. The ISHR-East ISHR. It was a great honor to Chair an ISHR tionships and friendships among the par- European Subsection was established in Congress, and the Council invariably had ticipants. The organizers of each Congress 1981, and the ISHR-Latin American and to make a difficult decision in selecting the arranged high quality, enjoyable social pro- ISHR-Chinese Sections were formed in successful proposal. The organization of a grams to showcase their hospitality, pride 1983 and 1984, respectively. Each Section Congress was not an easy task as one has to and commitment. Social events during the has a history of its own, and a brief account raise funds for all expenditures and assemble celebration of the 25th Anniversary of ISHR of the structure and development of each committees for scientific program, adminis- in Kobe, Japan were indeed a memorable Section will be presented in a future issue tration, hospitality, and entertainment. experience for all participants of the 1992 of the newsletter. Congress (Cover photo, Fig. 2). Each Congress was expected to achieve sev- Organization of International Congresses eral objectives: (i) holding several symposia Publications and Conference Proceedings All Chairs of the 16 international Congresses sessions on cutting-edge cardiovascular Although organizing meetings with high held between 1968 and 1998 (Table 5) had a science; (ii) exchanging information and quality scientific programs is a major func- strong commitment to promoting cardiovas- ideas for new lines of investigation to find tion of ISHR, publication of JMCC is the cular science; however, each of these indi- solutions for diverse and complex research flagship of this organization. The remarkable viduals had their own style in the selection of problems; (iii) providing opportunities for success and strength of JMCC over the years scientific program and delivery of their con- networking and developing research collab- can be attributed to its Founding Editors,

3 THE NEWS BULLETIN OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH

Table 5. World Congresses of the Study Group/ISHR (1968-1998). I. 1968 Dubrovnik, Croatia (Chair: Bajusz E, Boston)

II. 1969 Gargnano, Italy (Chair: Baroldi G, Milan)

III. 1970 Stowe (Vermont), USA (Chair: Raab W, Burlington)

IV. 1971 Tiervlei, South Africa (Chairs: Brink AJ and Lochner A, Bellville)

V. 1972 Winnipeg, Canada (Chair: Dhalla NS, Winnipeg)

VI. 1973 Freiburg, Germany (Chair: Fleckenstein A, Freiburg)

VII. 1974 Quebec City, Canada (Chair: Roy PE, Quebec City) VIII. 1976 Tokyo, Japan (Chair: Kobayashi T, Tokyo) Fig. 2: Drs. Jutta and Wolfgang Schaper (Bad Nauheim), and Albert Wollenberger (Berlin- IX. 1978 New Delhi, India (Chair: Tajuddin M, Aligarh) Buch) at a dinner party in Tokyo, Japan, 1976. Moscow, Soviet Union (Chair: Chazov E, Moscow) X. 1980 Infrastructure and Awards London, England (Chair: Harris P, London) XI. 1983 From 1968 to 1972, all the business and XII. 1986 Melbourne, Australia (Chair: Nayler W, Melbourne) affairs of the Study Group were conducted XIII. 1989 Ann Arbor, USA (Chair: Lucchesi B, Ann Arbor) through the office of Dr Eӧrs Bajusz at

XIV. 1992 Kobe, Japan (Chair: Ito Y, Tokyo) the Bio-Research Institute in Boston. He handled the bank account of the orga- XV. 1995 Prague, Czech Republic (Chair: Braveny P, Brno) nization himself and, except for the 1st Rhodes, Greece (Chairs: Hearse D, London; Ferrari R, Brescia) XVI. 1998 International Congress in Dubrovnik in Table 6. Editors of the Journal of Molecular and Cellular Cardiology (1970-1998). 1968, Dr Bajusz spent his own personal Years Editors Issues/Year Volumes money to finance Study Group activities including legal fees for registration. In 1970-1977 Richard J Bing 4 1, 2 Lionel H Opie 6 3-7 1972, Dr James Caulfield was elected as 12 8,9 Treasurer of the Study Group and became 1978-1979 Richard J Bing 12 10 Lionel H Opie responsible for handing financial matters Pierre Y Hatt including collection of membership dues. nd 1979-1980 Richard J Bing 12 11,12 Note that the expenditures for the 2 to 11th Congresses were the responsibility 1981-1986 Lionel H Opie 12 13-18 Arnold M Katz 12 19-24 of the organizers; they raised the funds 1987-1992 and spent the money on invited speakers, Norman R Alpert 12 25-30 1993-1998 conference hospitality and other organi- zational matters. With the election of Dr Drs Bing and Opie, but it is also important to ticipate. Accordingly, several Book Series, Naranjan Dhalla as Secretary General, the acknowledge the contributions of Academic “Recent Advances in Studies on Cardiac headquarters of the Study Group/ISHR Press in publishing this high impact journal. Structure and Metabolism” (1972-1978) and moved to the Experimental Cardiology Although JMCC was started as an associated “Advances in Myocardiology” (1980-1985) Laboratory, University of Manitoba project of the Study Group/ISHR in 1970 were published by the University Park Press, (1972-1987) and later to the St. Boniface and did not become the official journal of Baltimore as well as the Plenum Medical Hospital Research Centre (1987-1989). ISHR until 1981, all members of its Editorial Company, New York. The books contain The membership dues (collected directly) Board were appointed by officials of this review articles and original research papers during 1968-1972 were nominal, but organization from 1970-1998. In addition to and represent a true historical record of thereafter each Section was responsible Drs Bing and Opie, two other individuals, cardiovascular research during the 15 years for collecting their members’ dues and Drs Arnold M. Katz and Norman R. Alpert, of the development of ISHR. In 1992, the paying $3 per member annually to the served as early Editors of the Journal (Table ISHR Council initiated the publication of a Study Group/ISHR. With the election of 6) and thus guided its development from quarterly bulletin, “Heart News and Views”, Dr David Hearse in 1989, the headquarters 1987 to 1998. under the editorship of Dr Thomas Ruigrok, of ISHR was moved to London, England. for promoting communication among the It was the keen desire of the ISHR Council During the early stages of formation of the members and Sections of the organization. to promote the attendance of young inves- Study Group/ISHR, it was decided to pub- These publications have enhanced the pro- tigators at International Congresses. lish the proceedings of the Congresses for file of ISHR as a global institution. Accordingly, the Richard Bing Award the benefit of those who were unable to par- (continued on page 15)

4 VOLUME 23, NUMBER 3, 2018

San Diego in 2013, and most recently inPresident’s letter

he 2019 World Congress in Beijing is only a little more than a year away. The World Congress, organized by Dr. Yi Zhu, President of the Chinese Section, will be held June T3 to 6th in the Chinese National Convention Center (CNCC) in Beijing. Planning for the ~25 ISHR-sponsored symposia is underway. In response to a request for proposals, the membership submitted 91 symposium proposals which included 259 unique speakers. It will be a difficult job for the Scientific Program Committee (SPC) to select the final 25 symposia. The initial review process will be done by 7 Topic Groups: Cardioprotection; Cardiac Dysfunction; Ion Channels and Arrhythmia; Signaling, Disease and Therapy; Beyond the Genome; Regenerative Medicine; and Cardiac Metabolism. Each of the

Buenos Aires in 2016. The 2019 World7 Topic Groups has 2 Co-Chairs and 5 additional members. The Topic Groups will rankCongress and blend will bethe held symposia in Beijing! and submit roughly the top 50% to the SPC. The 15 member SPC is chaired by the Secretary General, Lea Delbridge, and composed of the two Co-Chairs of each topic groups: Asa Gustafsson and Derek Hausenloy (Cardioprotection);Future issues of HN&V Jolanda will Vanfollow-up der Velden on and Martin Vila Petroff (Cardiac Dysfunction); Livia Hool and Anna Maria ISHR history with articles from the surviv- Gomez (Ion Channels and Arrhythmia); Burns Blaxall and Tetsuji Miura (Signaling, Disease and Therapy); Tom Vondriska ing founding fathers (yes, not surprisingly andthey Issei were Komuro all men). (Beyond HN&V thewill Genome); also have Huang Tian Yang and Joe Wu (Regenerative Medicine); and Rong Tian and Rui- Pingarticles Xiao expanding (Cardiac Metabolism). on how the SocietyWe appreciate the hard work of the SPC in taking on this important task for the ISHR. grew and the history of the ISHR Sections. AnA international trivia question group for ISHR of Early history Career buffs: Investigators (ECIs) is also hard at work planning a symposium and other ECI eventswho knowfor the what World ISHR Congress. Section usedThe theECI Committee is composed of two representatives from each section: Kate Weeks andinitials Helen CIS? Viola (Answer from atthe the Australasian bottom of this Section, Shimizu Takeshi and Nakagawa Hitoshi from the Japanese Section, Chen page). Stay tuned for more trivia, history Gaoand and plans Randi for the Parks celebration. from the North American Section, Delphine Mika and Alessandra Ghigo from the European Section, Junjie Xiao and Ai Ding from the Chinese Section and Luis Gonano and Zully Pedrozo from the Latin American Section (representatives from the Indian Section will soon be appointed). In addition to planning activities at the World Congress thisCIS group (Commonwealth will liaise ofwith Independent ECIs in States)their Section to keep them informed. Litsa Kranias and Johannes Backs are serving as was the name of the Russian Section. advisors to the group. As a first order of business, the ECI group elected Kate Weeks as Chair and Chen Gao as Co-Chair. In addition to planning ECI symposia and social events for the World Congress, they are making plans for a travel bursary to provide travel funds for ECIs to visit labs in China in conjunction with the World Congress to learn techniques or initiate collaborations. We thank this amazing group of ECIs for all their work! It is also worth mentioning that the ISHR will again fund travel awards for ECIs to attend the World Congress in China.

Lastly, as I mentioned previously, this is the 50th Anniversary of the founding of the ISHR. We are planning a special cele- bration for the World Congress next year. Dr. Naranjan Dhalla, one of the founding fathers of the ISHR, has written a very comprehensive history of the early years of the ISHR. The initial installment of this history is included in this issue of Heart News and Views (p 1-4).

Elizabeth Murphy, Ph.D. President, ISHR

5 THE NEWS BULLETIN OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH Report on the Australasian Section Meeting (August 10-13, 2017; Perth, Australia)

he 41st annual International Society for Heart Research (ISHR) meet- L to R: Professor Livia Hool (President, Ting was held in conjunction with the Cardiac Society of Australia and ISHR Australasian Section), Professor New Zealand (CSANZ) meeting in Perth, Western Australia. The con- Lea Delbridge (ISHR-International ference started off with the RT Hall Lecture presented by Prof Stefan Representative), Dr Kate Weeks and Dr Neubauer (University of Oxford), demonstrating masterful application of Helena Qin (joint Early Career Investigator Oral Presentation winners) and Dr Jim Bell Cardiovascular Magnetic Resonance (CMR) imaging and spectroscopy, (ECR Development). both clinically and experimentally. Prof Robert Graham (Victor Chang Cardiac Research Institute) presented the Kempson Maddox Lecture, titled ‘The mysteries and enigma of spontaneous coronary artery dissec- tion’, and Prof Murray Esler (Baker Heart and Diabetes Institute) delivered the Basic Science Lecture: a highly informative lecture on sympathetic nervous system activation in hypertension. These lectures were a fitting representation of the fundamental research showcased at the conference by a range of ISHR scientists. Topics covered this year included cardiac regeneration, the role of inflammation and diabetes in heart disease, fetal heart development, cardiac remodelling, calcium signalling, and the role of epigenetics in the failing heart. ISHR Student Investigator Oral Presentation Our invited International Speakers this year The ISHR Australasian section has long Finalists with invited international speaker were Prof Joseph Hill (UT Southwestern been a proud supporter of both student and Professor Litsa Kranias. L to R: Professor Medical Center), Dr Scot Matkovich early postdoctoral researchers. Following on Litsa Kranias, Mr Darnel Prakoso, Ms Choon Boon (Evangelyn) Sim, Ms My-Nhan Nguyen (Washington University School of from the success of last year’s early career (winner) and Mr Mitchell Lock. Medicine, JMCC sponsored guest) and Prof researcher (ECR) events, ISHR Australasian winners. Joint first prize was awarded to Litsa Kranias (University of Cincinnati). section ECR representatives Dr Helena Dr Kate Weeks and Dr Helena Qin (both Prof Hill gave very informative lectures on Viola (University of Western Australia) from Baker Heart and Diabetes Institute), future heart failure issues from emerging and Dr Kimberley Mellor (University of with a runner up prize being awarded to Ms pre-diabetic populations. Dr Matkovich Auckland), once again organised an out- Upasna Varma (University Melbourne). The spoke on the role of noncoding miRNA standing Early Investigator Symposium symposium was followed by an informative and lncRNA in cardiac stress and disease, and Panel Discussion. This pre-ISHR meet- Panel Discussion on ‘Gene manipulation in while Prof Kranias gave presentations on ing event provides further opportunity for the future of cardiovascular therapeutics’ mutations in calcium cycling genes and the ECRs to engage with senior researchers, chaired by Dr Enzo Porrello (Murdoch emerging role of HSP20 in cardiac function and present their work at a major confer- Children’s Research Institute) and Prof and survival. These lectures were comple- ence. We had six outstanding presentations Fadi Charchar (Federation University). To mented with presentations from our talented from ECRs revolving around the theme of begin, Dr Jamie Vandenberg (Victor Chang local scientists covering a broad spectrum molecular mechanisms and predictors of Cardiac Research Institute) gave a basic of basic cardiac research that targeted phys- cardiac pathology. This year, for the very mechanism perspective on this topic, while iology, pathology, cell signalling as well as first time, several Early Career Investigator Dr Eddy Kizana (Westmead Institute for genomic and transcriptomic mechanisms Oral Presentation prizes were made avail- Medical Research) gave a clinical perspec- of healthy and diseased hearts. New in able, sponsored by ISHR-International. tive. Following these talks, Dr Matkovich 2017 were JMCC-sponsored sessions on The presentations were of such outstanding and Dr Adam Hill (Victor Chang Cardiac non-coding RNAs in health and disease. quality that the judges could not split the Research Institute) joined the discussion,

6 VOLUME 23, NUMBER 3, 2018

Best Student Free Communication Presentation winner Mr Matthew Chu ISHR President Professor Livia Hool pictured with ISHR invited international (centre) pictured with Professor Livia Hool (left) and Dr Jim Bell (right). guests. L to R: Dr Scot Matkovich, Profs Hool, Litsa Kranias and Joseph Hill. which included coverage of current knowl- Best Student Mini Oral for his presenta- p964-977). In this paper, Francine demon- edge of cardiac AAV gene therapy and tion titled ‘Using gene delivery to target strated that a diet high in fibre led to the obstacles faced by researchers for the Cardiac O-GlcNAc protein modifications changes in the gut microbiota that played successful translation of cardiac AAV gene in the diabetic heart: Impact on left ven- a protective role in the development of therapy into the clinic. Panel members and tricular function’, and to Mr Matthew cardiovascular disease. The favourable the audience provided engaging dialogue Chu (University of Adelaide) for the Best effects of fibre may be explained by the on this theme. Free Communication presentation titled generation and distribution of one of the ‘Circulating secreted frizzled-related pro- main metabolites of the gut microbiota, Further support for ECRs is reflected by tein 5 (Sfrp5) is decreased in patients with the short-chain fatty acid acetate. the opportunities given to young research- diabetes and is associated with diabetic ers to present their work and compete for control’. Congratulations to all of the stu- The ISHR Early Investigator Luncheon prizes. The 2017 ISHR Student Investigator dents who participated in these sessions. allowed delegates to interact with well-known Presentation Finalists were Ms My-Nhan international and local cardiac researchers Nguyen and Mr Darnel Prakoso (both from The ISHR Student Publication Award and clinicians including Profs Hill, Kranias, the Baker Heart and Diabetes Institute), was won by Mr Richard Tan (Heart Gemma Figtree (Univ of Sydney) and Dr Mr Mitchell Lock (University of South Research Institute), for his paper entitled, Matkovich. This year’s format was extremely Australia) and Ms Choon Boon (Evangelyn) ‘Non-invasive tracking of injected bone engaging as attendees were divided into Sim (University of Queensland). Well done marrow mononuclear cells to injury and smaller groups which allowed them to ask to all of the students for their excellent pre- implanted biomaterials’ published in Acta specific questions about career development sentations and responses to the questions Biomaterialia (2017, Volume 53, p378- to each panel member in a speed networking from the audience. Congratulations to the 388). In this paper, Richard demonstrated format. The overall concluding discussion winner, Ms Nguyen, for her presentation a new longitudinal tracking model that covered topics including what each panellist titled ‘Potential source of circulating galac- can non-invasively determine exogenous would seek in potential post-doctoral candi- tin-3 in heart failure: studies on patients bone-marrow mononuclear cells homing dates, advice on skills to increase competi- and cardiomyopathy mice’. and engraftment to biomaterials, providing tiveness, and pursuing overseas post-doctoral a valuable tool to inform the design of scaf- positions. Special thanks to the organisers Drs In addition to the ISHR Student Investigator folds with implications for countless tis- Viola and Mellor who contribute their time to presentations, the ISHR Mini Oral and Free sue engineering applications. Dr Francine make this event, and the pre-ISHR meeting Communication presentations are always Marques (Baker Heart and Diabetes ECR events possible. popular, providing another avenue for dis- Institute) took home the ISHR Postdoctoral cussion in cardiovascular research. These Publication Award for her paper published The annual AGM was held on Friday 11th sessions were well attended and covered in Circulation, titled ‘High-Fiber Diet and August at the Novotel Langley Perth. a wide range of topics from basic science, Acetate Supplementation Change the Gut Here Prof Livia Hool (President), Dr clinical, epidemiology, and studies con- Microbiota and Prevent the Development Colleen Thomas (Finance Secretary), A/ ducted in mice, rats, sheep and humans. of Hypertension and Heart Failure in Prof Rebecca Ritchie (Member Secretary), Congratulations to Mr Prakoso for winning Hypertensive Mice’ (2017, Volume 135, Dr Jim Bell and A/Prof Julie McMullen (continued on page 15)

7 THE NEWS BULLETIN OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH

recorded at baseline and on complete phar- ISHR-ES/SERVIER macological block of the autonomic ner- FELLOWSHIP 2014 vous system by application of previously validated doses10,11 of atropine and propran- A role for microRNA-423-5p in endurance olol. This shows that resting bradycardia in human athletes cannot be attributed to training-induced sinus bradycardia heightened vagal tone. We then assessed the role of HCN remodelling in human ath- t was a tremendous privilege to letes by administration of oral ivabradine receive the 2014 ISHR-ES/SERVIER that dose-dependently blocks HCN4 and I I .12,13 Figure 1B demonstrates that athletic Research Fellowship at the ISHR f European Section meeting in Barcelona. subjects (with a lower intrinsic heart rate At the time, my postdoctoral work (with after autonomic block) also had a blunted Professor Mark Boyett at the University response to the heart rate-lowering effect of ivabradine, supporting a role for I suppres- of Manchester) had uncovered a role f for electrophysiological remodelling of sion in the trained human sinus node. To the hearts pacemaker, the sinus node, our knowledge this is the first (albeit indi- in the resting bradycardia of endurance rect) evidence of pacemaker ion channel exercise. The Award supported an inves- remodelling in human endurance athletes. tigation of underlying microRNA (miR)- miR-423-5p controls HCN4 and I in the based mechanisms controlling heart f rate in the athlete and in the course of trained sinus node Alicia D’Souza the Fellowship we identified a prominent Having established a potential role for role for miR-423-5p. Our work, summarised here, is the first exploration HCN4 remodelling in human athletes of ion channel remodelling in human endurance athletes and is the first we went on to investigate an underlying demonstration of miR-dependent control of heart rate. role for miRs in a mouse model of swim training-induced bradycardia and HCN4 downregulation.3 Small non-coding RNAs Heart rate is set by a relatively small pop- Why do athletes have a slow heart rate? including miRs are known to pay pivotal ulation of myocytes in the sinoatrial node There are well documented cardiac elec- roles in controlling and fine tuning -car that possess a unique ion channel makeup trophysiological changes that accompany diac remodelling in physiological and and electrophysiological profile resulting chronic vigorous endurance exercise, the pathological settings and previous work in the generation of diastolic depolarisa- most common of which is sinus bradycar- has shown that miRs regulate expres- 1 tion and automaticity. Plasticity in the dia. Training-induced bradycardia is widely sion of ion channels in the heart.14-16 To 6 molecular profile of the sinus node allows attributed to high vagal tone, but our recent investigate miR involvement in the train- 3 7-9 for basal heart rate adaptation in response work has stimulated debate on the rela- ing-induced downregulation of HCN4 we to acute and chronic stimuli. Modification tive contribution of altered autonomic initially obtained an unbiased view of the of pacemaking ion channel expression is nerve activity vs. intrinsic changes to sinus ‘miRome’ in sinus node biopsies from bra- an important mechanism in heart rate reg- node pacemaking in underlying this effect. dycardic swim-trained mice and sedentary ulation and has been reported in a range In two rodent models of exercise training, controls using (Illumina miSeq) next gen- 2 of physiological (e.g. ageing , athletic we demonstrated that training-induced eration sequencing. In silico approaches 3 training ) and pathological (e.g. heart fail- bradycardia is predominantly the result of were then applied to significantly dys- 4 5 ure , atrial fibrillation ) settings resulting a downregulation of the key pacemaking regulated miRs (Fig. 2A) to generate a in changes to sinus node function. The ion channel HCN4 and its corresponding list of candidate miR-HCN4 pairs based upstream determinants of ion channel ionic current (funny current, If) in the sinus on canonical complimentary base pairing 3 remodelling in the sinus node are not fully node. In the present study we first tested between miRs and the HCN4 3’ untrans- understood and here we focused on regu- whether these concepts were applicable to lated region (UTR). These computational latory mechanisms controlling expression human athletes. As shown in Fig. 1A, we predictions were verified in vitro using a of the key pacemaking channel HCN4 in demonstrated a lower intrinsic heart rate in luciferase reporter gene assay wherein the context of endurance exercise. endurance trained athletes vs. non athletes, the HCN4 3’-UTR was fused to a lucif-

8 VOLUME 23, NUMBER 3, 2018 erase reporter gene and co-transfected with precursor miR-423 in h9c2 cells. Of the potential HCN4-targeting miRs tested, miR-423-5p produced the largest dose-dependent reduction in luciferase activity (Fig. 2B) and this effect was abol- ished by mutation of specific recognition elements in the HCN4 3’UTR (Fig. 2C). Interestingly, training-induced upregula- tion of miR-423-5p was restricted to the sinus node i.e. its expression was unaltered in the trained right atrium and left ventri- cle and was also restored on de-training (Fig 2D). These lines of evidence led to Figure 1. (A) Heart rates measured under baseline conditions and after complete the hypothesis that the training-induced autonomic blockade in sedentary human subjects and human athletes (B) Relationship between ivabradine-induced decrease in heart rate and the intrinsic heart rate measured upregulation of miR-423-5p could trigger after complete autonomic blockade in sedentary human subjects and human athletes. HCN4 downregulation and consequently *P<0.05. Modified from D’Souza et al.17 a lower heart rate. We investigated this possibility further using a loss-of-func- tion approach by in vivo administration of cholesterol-conjugated anti-miR-423-5p (antimiR). Remarkably, antimiR restored the heart rate measured in vivo and in vitro towards the pre-training level (Fig. 3A) concomitant with a reversal in protein levels of HCN4 (detected by western blot, Fig. 3B). Accordingly, whole cell patch clamp recordings from isolated sinus node cells confirmed a 54% percent reduction in If in trained mice that was almost fully restored in antimiR-treated trained mice (Figs. 3C and 3D). To our knowledge, these observations were the first report of miR-dependent control of pacemaking ion channels and heart rate.

Concluding remarks In summary, research conducted during the ISHR-ES/Servier Fellowship confirmed the role of intrinsic changes to pacemaker electrophysiology in underlying the rest- ing bradycardia of endurance exercise in human athletes and provided novel insight into training-induced epigenetic control mechanisms regulating heart rate.17 miRs have shown recent promise as ‘druggable’ targets approaching bedside transition18 and thus the finding of sinus node-specific Figure 2. (A) Significant training-induced changes in miR expression measured by next generation sequencing in sinus node of mice. (B) HCN4-3’UTR luciferase reporter assay up regulation of miR-423-5p as an import- in H9C2 cells showing specific targeting of HCN4 3’UTR by selected co-transfected miRs. ant regulator of HCN4 expression might (C) Luciferase reporter assay showing dose-dependent repression of HCN4 by miR-423- have translational potential, especially in 5p and loss of repression by mutation of HCN4 3′-UTR (D) mRNA expression of miR-423- 5p from sedentary and trained mice. *P<0.05. Modified from D’Souza et al.17

9 THE NEWS BULLETIN OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH

7 Boyett, M. R. et al. Viewpoint: is the resting bradycardia in ath- letes the result of remodeling of the sinoatrial node rather than high vagal tone? Journal of Applied Physiology 114, 1351-1355, doi:10.1152/jap- plphysiol.01126.2012 (2013).

8 Boyett, M. R. et al. Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function. Journal of Applied Physiology 123, 684-685 (2017).

9 D’Souza, A., Sharma, S. & Boyett, M. R. CrossTalk opposing view: bradycar- dia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node. The Journal of Physiology 593, 1749-1751 (2015).

Figure 3. (A) Mean heart rates measured in vivo and in the isolated sinus node. (B) 10 Jose, A. D. & Taylor, R. R. Autonomic Western blots using antibodies against HCN4 and β actin proteins from sinus node blockade by propranolol and atro- biopsies (C) Representative If traces (normalised to cell capacitance) and (D) mean current-voltage relationships for If. *P<0.05. Modified from D’Souza et al.17 pine to study intrinsic myocardial function in man. Journal of Clinical the veteran (i.e. older) athlete; veteran ath- Nature Communications 5, 3775, Investigation 48, 2019-2031, letes can present with a higher incidence doi:10.1038/ncomms4775 (2014). doi:10.1172/JCI106167 (1969). of electronic pacemaker implantation for 4 Zicha, S., Fernandez-Velasco, M., 19-21 sinus node disease and targeting miRs Lonardo, G., L’Heureux, N. & Nattel, 11 Katona, P. G., McLean, M., Dighton, in the sinus node may represent a viable S. Sinus node dysfunction and hyper- D. H. & Guz, A. Sympathetic and alternative therapeutic strategy. polarization-activated (HCN) chan- parasympathetic cardiac control in ath- nel subunit remodeling in a canine letes and nonathletes at rest. Journal References heart failure model. Cardiovascular of Applied Physiology 52, 1652-1657 1 Dobrzynski, H. et al. Structure, func- Research 66, 472-481, doi:10.1016/j. (1982). tion and clinical relevance of the car- cardiores.2005.02.011 (2005). diac conduction system, including the 12 Bucchi, A., Baruscotti, M. & atrioventricular ring and outflow tract 5 Yeh, Y. H. et al. Funny current down- DiFrancesco, D. Current-dependent tissues. Pharmacology & Therapeutics regulation and sinus node dysfunction block of rabbit sino-atrial node I(f) 139, 260-288, doi:10.1016/j. associated with atrial tachyarrhythmia: channels by ivabradine. Journal of pharmthera.2013.04.010 (2013). a molecular basis for tachycardia-bra- General Physiology 120, 1-13 (2002). dycardia syndrome. Circulation 2 Tellez, J. O. et al. Ageing-dependent 119, 1576-1585, doi:10.1161/ 13 Ragueneau, I. et al. Pharmacokinetic- remodelling of ion channel and Ca2+ CIRCULATIONAHA.108.789677 pharmacodynamic modeling of the clock genes underlying sino-atrial node (2009). effects of ivabradine, a direct sinus pacemaking. Experimental Physiology node inhibitor, on heart rate in healthy 96, 1163-1178, doi:10.1113/exp- 6 Coote, J. H. & White, M. J. CrossTalk volunteers. Clinical Pharmacology and physiol.2011.057752 (2011). proposal: bradycardia in the trained Therapeutics 64, 192-203, doi:10.1016/ athlete is attributable to high vagal s0009-9236(98)90153-9 (1998). 3 D’Souza, A. et al. Exercise training tone. The Journal of physiology 593, reduces resting heart rate via downreg- 1745-1747 (2015). ulation of the funny channel HCN4.

10 VOLUME 23, NUMBER 3, 2018

14 Lu, Y. et al. MicroRNA-328 contrib- 17 D’Souza, A. et al. Targeting miR- utes to adverse electrical remodel- 423-5p Reverses Exercise Training- 20 Northcote, R. J., Rankin, A. C., ing in atrial fibrillation. Circulation Induced HCN4 Channel Remodeling Scullion, R. & Logan, W. Is severe 122, 2378-2387, doi:10.1161/ and Sinus Bradycardia. Circ Res bradycardia in veteran athletes an CIRCULATIONAHA.110.958967 121, 1058-1068, doi:10.1161/ indication for a permanent pace- (2010). CIRCRESAHA.117.311607 (2017). maker? British Medical Journal 298, 231-232 (1989). 15 Yang, B. et al. The muscle-specific 18 Rupaimoole, R. & Slack, F. J. microRNA miR-1 regulates cardiac MicroRNA therapeutics: towards a 21 Baldesberger, S. et al. Sinus node arrhythmogenic potential by targeting new era for the management of can- disease and arrhythmias in the long- GJA1 and KCNJ2. Nature Medicine 13, cer and other diseases. Nat Rev Drug term follow-up of former profes- 486-491, doi:10.1038/nm1569 (2007). Discov 16, 203-221, doi:10.1038/ sional cyclists. Eur Heart J 29, 71-78, nrd.2016246 (2017). doi:10.1093/eurheartj/ehm555 (2008). 16 Girmatsion, Z. et al. Changes in microRNA-1 expression and IK1 up-reg- 19 Northcote, R. J., Canning, G. P. & ulation in human atrial fibrillation.Heart Ballantyne, D. Electrocardiographic Rhythm 6, 1802-1809, doi:10.1016/j. findings in male veteran endurance hrthm.2009.08.035 (2009). athletes. British Heart Journal 61, 155-160 (1989).

Calendar

■ May 29-June 1, 2018. XXXVII Annual Meeting of the North American Section. Halifax, NS. Inquiries: Susan Howlett, [email protected]; Website: www.american.ishrworld.org

■ July 16-19, 2018. XXXV Annual Meeting of the European Section. Amsterdam, the Netherlands. Website: www.ishr2018.amsterdam

■ August 2-5, 2018. XLII Annual Meeting of the Australasian Section (held jointly with the Cardiac Society of Australia and New Zealand). Brisbane, Australia.

■ September 5-8, 2018. Annual Meeting of the Latin American Section. Santiago, . Inquiries: Sergio Lavandero, [email protected]

■ September 20-22, 2018. XIV Annual Meeting of the Chinese Section. Nanjing, China

■ December 7-8, 2018. XXXV Annual Meeting of the Japanese Section. Tokyo, Japan. Inquiries: Hiroyuki Tsutsui, [email protected]

■ June 3-6, 2019. XXIII ISHR World Congress. Beijing, China.

11 THE NEWS BULLETIN OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH

Stephan Lange is Meet the 2017-2019 an Asst Professor in the Cardiovascular ISHR-NAS Early Career Division of the UC Investigator (ECI) San Diego School of Medicine. Stephan’s Committee lab investigates mus- cle development, signaling and mainte- The ECI committee of the ISHR-NAS is nance, by studying the biological role of dedicated to promoting training, develop- Natasha Fillmore is sarcomeric and muscle associated pro- ment and networking among early career a postdoctoral fellow teins. His group is particularly interested cardiovascular scientists - through orga- in the Laboratory of in deciphering molecular mechanisms that nized events at ISHR Section Meetings Cardiac Physiology play a role in the development of cardiac as well as interactions over various digital with Dr. Elizabeth and skeletal muscle myopathies, such as platforms. We look forward to working Murphy at the the signaling pathways driving dilated with all members of the ISHR and are NHLBI, NIH. cardiomyopathy and the contribution of always seeking input from the community Natasha’s research interests include regulated protein turnover. on how we can better serve you. understanding the mechanisms involved in regulating energy metabolism and the Cat Makarewich is a Erik Blackwood development of cardiovascular disease. postdoctoral fellow in is a doctoral stu- Dr. Eric Olson’s Lab dent in the Cell and Manuel Rosa in the Department of Molecular Biology Garrido is an Asst Molecular Biology Joint Program at Project Scientist at UT Southwestern SDSU and UCSD in the lab of Dr. Medical Center. Cat’s in the lab of Dr. Thomas Vondriska work has focused on a collection of small Chris Glembotski. Erik’s current research in the Department of proteins encoded by short open reading focuses on cardiac hormone secretion as Anesthesiology & frames hidden within RNAs that are incor- a therapeutic target for hypertension and Perioperative Medicine at UCLA. Manuel rectly annotated as noncoding RNAs, spe- hypertrophic cardiomyopathy as well as is focused on studying the structure of the cifically a subclass of these peptides that drug development strategies for novel cardiac genome during heart failure, in regulate contractility and calcium homeo- pharmacologic interventions in myocar- order to develop diagnostic features that stasis in the heart. She is currently study- dial infarction or stroke. can predict disease, greatly improve out- ing the function and regulation of these comes, and identify master regulators that peptides during development and disease. Samarjit (Sam) can be manipulated therapeutically. Das is a Research Randi Parks is a Associate in the Kim Ho is a stu- postdoctoral fellow Cardiovascular dent in the Master of with Dr. Elizabeth Division of the Johns Science in Medical Murphy in the Hopkins School of Sciences and Laboratory of Cardiac Medicine. Sam’s Pediatrics program Physiology, NHLBI, research focuses on the functional conse- at the University of NIH. Randi’s overall quences of microRNAs in cardiovascular Alberta with Dr. Gary research interest is in calcium signaling disease. Sam’s lab is particularly interested Lopaschuk and Dr. within subcellular compartments of the in microRNAs which do not follow the John Ussher. Kim is currently studying heart, both physiological and pathophys- conventional mRNA suppression pathway, the cardiac metabolic perturbations that iological. Her current research is focused mitochondrial microRNA biogenesis, and occur with heart failure and diabetes, spe- on understanding cardiac mitochondrial microRNA degradation pathways. They cifically the mechanisms and implications calcium flux and how calcium overload also study the phenomenon of cell-cell and of ketone body oxidation in these settings. mediates mitochondria-triggered cell death organ-organ communication via exosomal via the permeability transition pore. microRNAs.

12 VOLUME 23, NUMBER 3, 2018

Ron Vagnozzi is a post- thelial cells. His overall goal is to define We encourage everyone in the ISHR doctoral fellow with Dr. endogenous mechanisms of the cardiac injury early career community to get involved! Jeff Molkentin in the and stress response, and how these might be For more information please get in Division of Molecular manipulated by new therapeutics. touch with us through the ISHR-NAS Cardiovascular groups on Facebook: https://www.face- Biology and the Heart The 2017-2019 committee is Chaired book.com/groups/ECI.ISHR/members/ Institute at Cincinnati by Sam Das. Vice-Chair; Ron Vagnozzi. or LinkedIn: https://www.linkedin.com/ Children’s Hospital. Ron is focused on mech- Secretary; Erik Blackwood. Senior advi- groups/2596502 and plan to join us on anisms of tissue repair and injury resolution. sory committee members are Drs. Litsa May 29 – June 1, 2018 for the ISHR- He is currently exploring cellular processes Kranias and Jeff Robbins. NAS Section Meeting in Halifax, which underlying repair capacity in the adult heart, will feature an ECI scientific symposium with an emphasis on macrophages and endo- and career development workshop!

diac pathophysiology (speakers: Manuela REPORT ON THE XXIV LATIN Lavorato (USA), Irene Ennis (Argentina), AMERICAN SECTION Alejandro Aiello (Argentina), Alberto Crottogini (Argentina)), and Regulation of calcium homeostasis in cardiac health (April 20-22, 2017; Mendoza, Argentina) and disease (speakers: Peter Jones (New Zealand), Daniel Gonzalez (Chile), Julieta his year, while recalling the successful World Congress of the International Palomeque (Argentina) and Maria de TSociety for Heart Research (ISHR) held in Buenos Aires in 2016, the annual Fatima Leite ()) (Fig 1). The chairs meeting of the ISHR Latin American Section was held in Mendoza, Argentina, for these two symposia, Dr. Irene Ennis the “land of wines”. The meeting venue was the beautiful Hotel InterContinental, and Dr. Carlos Valverde, and Dr. Cecilia located outside the downtown area of Mendoza. After arriving at Mendoza air- Mundiña-Weilenmann and Dr. Paulina port, the conference attendees enjoyed the atmosphere of the most important Donoso, respectively, were very effective wine producing Province of Argentina with the magnificent Andes Mountains in in expediting discussion and questions the background. between the attendees and the speakers.

a meeting that usually attracts 2,500 We also had the pleasure of attending Dr. attendees. Holding the LA ISHR meeting Sergio Lavandero’s (Chile University) in collaboration with the SAHA Annual plenary lecture entitled “Therapeutic Meeting was an excellent joint venture targeting of autophagy in myocardial because it brought clinicians closer to infarction and heart failure”, which was basic science and enriched the discussions an outstanding presentation on a poten- held during the symposia by mixing basic tial therapeutic approach for the treatment science with clinical approaches to treat- of these two pathologies. The outgoing ing and diagnosing patients. President of the ISHR-LA, Dr. Martín Vila Pertroff, chaired Dr. Lavandero´s talk with Even though the meeting was held in a city enthusiasm, facilitating a time for questions that is 1,000 km away from Buenos Aires, and discussion among the numerous attend- PhD students, postdocs and investigators ees at the lecture. Dr. Daniel Gonzalez gave an excellent attended the meeting from Argentina, presentation on RyR modulation by oxidative modifications. Brazil, Chile and . This year Immediately after the lecture, members of The 2017 ISHR Latin American we were delighted to welcome interna- the LA ISHR attended the Annual General (ISHR-LA) meeting was organized by tional speakers from USA (Dr. Manuela Assembly. As usual, the ISHR-LA trea- Dr. Martin Vila Petroff in collaboration Lavorato) and New Zealand (Dr. Peter surer (Julieta Palomeque on this occa- with the XXIV Congress of the Argentine Jones). The ISHR-LA meeting consisted of sion), presented the annual financial report Society of Arterial Hypertension (SAHA), two Symposia: Signaling pathways in car- which was accepted and approved by all

13 THE NEWS BULLETIN OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH

with the latest unpublished data. These ses- sions were full of enthusiasm and covered all areas of cardiovascular research, creat- ing the perfect opportunity for interaction between young and senior investigators. ISHR-LA also provided twenty travel awards for young fellows and investiga- tors. The selected recipients were from Argentina, Chile and Brazil.

Many meeting participants took advantage of the opportunity to taste Mendoza´s wines complemented with typical Argentine beef in some of the many restaurants in the downtown area of Mendoza (a ‘must-do’ Enjoying a cocktail before the closing lunch at a famous wine cellar in Mendoza. (left to in this city)(Fig 2). Other attendees went right) Peter Jones, Martin Vila Petroff, Maria Fatima Leite, Irene Ennis, Celeste Villa Abrille, horseback riding and sightseeing in the Alejandra Yeves, Julieta Palomeque, Carlos Valverde and Manuela Lavorato. mountains. After the closing ceremony, the invited international speakers and the ISHR-LA committee were invited to a clos- ing lunch at Bodega Séptima, one of the most important wine cellars in Mendoza and in the country (Fig 3). The participants promoted their mutual friendship with deli- cious food and one of the best red wines in Argentina in an intimate and friendly atmo- sphere. After lunch, they enjoyed a music band that encouraged all attendees to dance different rhythms, including Tango.

As mentioned previously, the next annual meeting (2018) will be held in Chile. We look forward to seeing each other again and sharing not only the latest developments in science from our region, but also our natu- The ISHR committee and invited speakers out to dinner in downtown Mendoza. (left to right, above) ral and true friendship. A special invitation Julieta Palomeque, Gina Sanchez, Carlos Valverde, Daniel Gonzalez, Martín Vila Petroff, Peter Jones, (below) Cecilia Mundiña-Weilenmann, Irene Ennis, Alicia Mattiazzi, Manuela Lavorato, is extended to all Sections of the ISHR. Emiliano Diez, Alejandro Aiello, Sergio Lavandero and his wife, and Paulina Donoso. Finally, we want to thank ISHR-International for providing financial support for the two members. In addition, Dr. Vila Petroff firm that the 2018 annual meeting will JMCC-sponsored symposia in the ISHR-LA presented a report on ISHR-LA activi- be in Santiago, Chile, and will surely be 2017 Annual Meeting in Mendoza. ties and announced the nominee for the another successful event. President of the ISHR-LA 2018-2020, Carlos Valverde Sergio Lavandero. This proposal was Our younger investigators and PhD stu- Centro de Investigaciones approved unanimously, and after his first dents participated in two poster sessions in Cardiovasculares “Dr Horacio E words as President-Elect we can con- which they presented more than 30 posters Cingolani”, Argentina

14 VOLUME 23, NUMBER 3, 2018

(50th Anniversary continued from page 4) for Young Investigators was established from his contacts in Japan. These funds Naranjan S. Dhalla, in 1978 and 4 to 6 young investigators were received in 1994 as endowments to Distinguished Professor, University of were invited to compete for the Award hold 3 named symposia sessions at each Manitoba, Institute of Cardiovascular at each Congress. Likewise, the Council ISHR Congress. The ISHR Council was Sciences, Max Rady College of established the Peter Harris Distinguished authorized to select the speakers as well Medicine, St. Boniface Hospital Scientist Award and Outstanding Research as topics for the Bayer, Canon and Koito Albrechtsen Research Centre, Award in 1984 for the recognition of estab- Symposia and to use the interest from Winnipeg, Canada lished investigators. The winners of both the Endowment Fund for expenses. Such these Awards were carefully selected and efforts in fundraising and income gener- 1968 Founding Member of the Study invited to each Congress to give special ation built the financial base of the ISHR Group/ISHR lectures. All three Awards became very and offset operational costs. 1970 Council Member of the Study popular and lent respectability to ISHR. Group/ISHR Concluding Remarks 1972-1989 Secretary General of the It became increasingly difficult to fund the I have taken appropriate care in depicting Study Group/ISHR operation of ISHR with membership dues. events associated with numerous individ- 1989-1998 Pres-Elect, President, Past- Funding the organization of Congresses uals, who in my opinion have served this Pres of the ISHR with donations from the pharmaceutical organization in different capacities with or medical device industries was diffi- great distinction. If I have made any omis- 1974-1985 Exec Sec of the American cult; furthermore, the services of a full- sion or described any event inaccurately, Section time individual was needed to run the it was not my intention to offend anybody 1985-1994 Pres-Elect, President, Past- affairs of ISHR. Thus funds from alternate because I have always believed that: “In Pres of the American Section resources were needed. Several individu- this Mortal World, people come and go, als, including Drs Norman Alpert, Philip they perform their tasks but do leave their Poole-Wilson, David Hearse and Naranjan footprints behind for others to trace the Dhalla, were successful in renegotiating history for the development and progress the contract with Academic Press, London of events, and particularly to appreciate (JMCC Publisher) to provide substantial the agony and ecstasy they experienced for income to ISHR on an annual basis effec- the accomplishment of their mission”. It is tive 1993. In addition, both Drs Howard amazing to see that most of my professional Morgan (in his capacity as Chair of the life has revolved around this organization ISHR Finance Committee) and Naranjan and its diverse members. I have served Dhalla (as President of ISHR) were suc- ISHR with a deep sense of commitment cessful in persuading Professor Makoto and extraordinary passion and I am grate- Nagano (President of the Japanese Section ful to the many cardiovascular leaders who of ISHR) to obtain $300,000 for ISHR gave me the opportunity to know them.

Dr. Dhalla

(AUSTRALASIA continued from page 7)

(ECR Development) gave a summary of meeting, the achievements of the section thus the Australasian section’s activities over the far, and stimulating lively discussion about past year. The AGM was followed by the the ever growing future of the Australasian The next CSANZ / ISHR annual ISHR dinner, also held at the Novotel section of the ISHR. Australasian Section meeting will be Langley. The ISHR dinner made for a won- held in Queensland at the Brisbane derful opportunity to network with fellow Mr Mitchell Lock, Mr Darnel Prakoso, Convention Centre, 2-5 August 2018. ISHR members and our international guests Ms Choon Boon (Evangelyn) Sim and Dr all while celebrating a highly successful Bianca Bernardo

15 THE NEWS BULLETIN OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH

DIALOGUES IN CARDIOVASCULAR MEDICINE DIALOGUES IN CARDIOVASCULAR MEDICINE OCTOBER 2017 VOLUME 22 #3

Barcelona ESC 2017

ESC Barcelona 2017 This publication is supported by an unrestricted grant from Institut La Conférence Hippocrate - Servier Research Group

18 CH 0496 BA 0496 CH 18

www.dialogues-cvm.com

Get the latest news from the main cardiology meetings! The journal provides up-to-date information on specifi c areas of cardiovascular medicine and encourages dialogue between key opinion leaders and readers.

Read the latest issue online: www.dialogues-cvm.com

HEART NEWS AND VIEWS T. Izumi A.-M.L. Seymour is the official News Bulletin of the Kanagawa, Japan Hull, UK Japanese Section International Society for Heart Research N. Takeda and is published every fourth month. B. Bernardo Tokyo, Japan Melbourne, Australia K.K. Talwar Australasian Section Editor Chandigarh, India L. Anderson Lobaugh X.Y. Li Indian Section Durham, NC, USA Beijing, China D. Eisner E-mail [email protected] Chinese Section Manchester, UK Founding Editor A. Mattiazzi La Plata, Argentina T.J.C. Ruigrok B.J. Ward Latin American Section London, UK Wijk bij Duurstede, The Netherlands E-mail [email protected] B. McDermott K.T. Weber Belfast, UK Memphis, TN, USA Editorial Board European Section R.A. Altschuld E. Murphy Editorial Office Columbus, OH, USA Bethesda, MD, USA 3711 Lochn’ora Parkway M. Avkiran President Durham, NC 27705 London, UK USA. T. Ravingerova Phone/Fax: +1 919 493 4418 Past-President Bratislava, Slovak Republic R. Bolli Louisville, KY, USA 16