Department Profile

BHARATHIDASAN UNIVERSITY Tiruchirappalli- 620 024, India

DEPARTMENT OF BIOCHEMISTRY

PROFILE 2

National Recognitions

DST-FIST (Level I)

RUSA

DST- PURSE

Faculty Members

Dr. Vasanthi Nachiappan Professor and Head

Dr. Anusuyadevi Jayachandran Assistant Professor

Dr. C. Prahalathan Assistant Professor

Dr. V. Ravikumar Assistant Professor

Dr. A. Antony Joseph Velanganni Assistant Professor

Dr. A.N. Dhina Guest Lecturer

Preface

The Department of Biochemistry was established in the year 2005. Department offers a two-year M.Sc Progarm in Biochemsitry, one-year M.Phil Program and Ph.D program in various specializations. We also actively involved in teaching M.Sc Life Science Students and handle courses related to Biochemistry. Biochemistry is an integrated subject fulfilling the need for basic as well as applied aspects of biology and prepares the students to become entrepreneur, teacher, researcher, or to fit into equipping themselves to the future needs along with the basic and applied knowledge of modern biology. Keeping in view the updates and trends among International Institutes around the world, we frequently update the syllabus inculcating international standards and modernize the curriculum that will benefit our younger generation and qualify them to contribute to the welfare of the society. All the faculty members of Deparment of Biochemistry have got their research specialization from various leading laboratories around the world and got intense training during their post doctoral experience. The main areas of research includes, Membrane Biochemistry, Cancer Biology, Neurogerontology, Reproductive Biology etc., We have produced more than 20 PhD‟s who have got placed as scientist, post doctoral fellows in various leading International Institutes like in USA, Korea, Sweden. Within the short span time, the Department has grown into a vibrant academic department and research centre in Biochemistry, where we have made great stride in higher education, research and extension activities in the area of specialization. The Department was recognized for DST-FIST Program in the year 2012. The department has generated funds worth five plus crores for Research and Infrastructure from various funding agencies like CSIR, NFMP, DST, DBT, ICMR, UGC etc., To add on to the credentials, more high impact factor publications has been made in well reputed Journals and published many book chapters in the core area of research. The department has hosted many national level conferences and workshops benefiting students.

Professor and Head

Objectives:

 To conceive and conduct programmes in Biochemistry at Post-graduate and M.Phil. levels to train manpower for the Academic and Research Institutions

 To carry out Basic, Applied and Advanced Research in various fields of Biochemistry

Vision and Mission

 Create a suitable ambience for students & teachers to  Promote higher learning  Solve vital problems in Biology & Medicine  To promote higher learning on par with international standards.  To solve vital problems in biology and medicine for welfare of humanity.  To implement quality work to enable scholars to do imperative research. 6

Faculty I

Area of Research/Specialization: Our lab focuses on the role of transcription factors and their involvement in lipids during adverse conditions. Environmental pollutants and heavy metals have an impact on yeast phospholipids. Understanding the lipid related metabolic pathways during such adverse conditions may provide knowledge for developing novel therapeutics for these toxicity related disorders. We use combination of genetics and molecular approaches to implicate the role of genes and proteins that regulate lipid metabolism under pathological conditions using Saccharomyces cerevisiae and human cell line as model system. Dr. Vasanthi Nachiappan Achievements made in Teaching/Research/Extension Professor & Head

No. of Research Publications : 45 No. of papers presented in Conferences : 26 h-index : 14 i-10 index : 17 Total Citations : 586 Patents Granted/Filed : -- Products Developed : -- Projects Completed/Ongoing : 3/1 Consultancies Completed/Ongoing : --

Awards and Recognitions  Indian Association of Biomedical Scientists (Iabms) Award For Dr. C. R. Krishnamurthy Memorial Award Nov 4th 2016  Post Doctoral Training at USA for about six years (1989 to 1995)  Product Development in Collaboration with Indian Institute of Science for about eight years. Research Group Members  C. Ravi  R. Gowsalya  N. Bhanupriya  M. Arul  S. Vennila  M. Subitha

Past Members 1. Dr. P. Vijayaraj 5. Dr. Karpagam 9. Dr. C. Sivaprakasam 13. Dr. R. Vijayakumar 2. Dr. K. 6. Dr. S. Shanmughapriya 10. Dr. S. Rajakumar 14. Dr. Abhishek Raj Muthukumar 3. Dr. J. Sabatirajan 7. Dr. K. Selvaraju 11. Dr. D. Kalyani 4. Dr. K. Jyothi 8. Dr. L. Vishnuvarthini 12. Dr. A. William James

Faculty II

Area of Research/Specialization:

Molecular Neurogerontology

Dr. M. Anusuyadevi Jayachandran Achievements made in Teaching/Research/Extension Assistant Professor No. of Research Publications : 25 No. of papers presented in Conferences : 34 h-index : 14 i-10 index : 14 Total Citations : 804 Patents Granted/Filed : -- Products Developed : -- Projects Completed/Ongoing : 4/1 Consultancies Completed/Ongoing : --

Awards and Recognitions  Young Faculty Award, VIFFA 2015  Young scientist award – DST  Young Investigator award – DBT  Post-doctoral Scholar, Medical University of South Carolina, Dept. of Physiology and Neurosciences, U.S.A. (2007 to 2008)

Research Group Members  Mrs. Meher Nisha  Ms. M. Suhadha Parveen  Mr. Syed Aasish Roshan

Past Members

1. P.Premkumar 2. M.Sathya 3. C.Karthick 4. P.Moorthi 5. S.Periyasamy 6. ML. Mini 8

Faculty III

Area of Research/Specialization:

Molecular Endocrinology

Dr. C. Prahalthan Achievements made in Teaching/Research/Extension Assistant Professor

No. of Research Publications : 20 No. of papers presented in Conferences : 17 h-index : 13 i-10 index : 13 Total Citations : 705 Patents Granted/Filed : -- Products Developed : -- Projects Completed/Ongoing : 4/1 Consultancies Completed/Ongoing : --

Awards and Recognitions

 Young Investigator Award – DBT  Young Scientist Award – SERB  Receipient of American Heart Association Postdoctoral Fellowship, USA.  Postdoctoral Fellowship from American Diabetes Association, USA.

Research Group Members

 K. Arun  P. Anto Jenifer  M. Lezy Flora

Past Members

1. Dr. S. Mohanraj 2. Dr. B. Sivasangari 3. Dr. R. Balamurugan

Faculty IV

Area of Research/Specialization:

Epigenetic Regulation in Lung Cancer

Dr. V. Ravikumar Achievements made in Teaching/Research/Extension Assistant Professor No. of Research Publications : 40 No. of papers presented in Conferences : 19 h-index : 15 i-10 index : 12 Total Citations : 569 Patents Granted/Filed : -- Products Developed : -- Projects Completed/Ongoing : 2/1 Consultancies Completed/Ongoing : --

Awards and Recognitions  Young Scientist awarded - SERB  Postdoctoral training from Kyung Hee University, Korea.  Project Fellow awarded by University Grants Commission programme of Institute for Herbal Sciences, Govt. of India.  Scientist (R&D) at Biosewoom Inc., Institute of Bioscience and Biotechnology, Seoul, Korea. (Apr 2008 – Sep 2008).  Postdoctoral Research Fellowship awarded by Brain Korea 21 scheme, Government of Korea (2006- 2008).

Research Group Members

 K. Varunkumar  C. Anusha  A. Kalairasi  K. Sarvanan  Dindi Uma Maheswara Rao  S. Prabhu

Past Members 1. Dr. S. Karthik 2. Dr. R. Sankar

Faculty V

Area of Research/Specialization:

Molecular Oncology

Dr. A. Antony Joseph Velanganni Achievements made in Teaching/Research/Extension Assistant Professor

No. of Research Publications : 12 No. of papers presented in Conferences : 1 h-index : 5 i-10 index : 4 Total Citations : 83 Patents Granted/Filed : -- Products Developed : -- Projects Completed/Ongoing : 3/1 Consultancies Completed/Ongoing : --

Awards and Recognitions

 Young Scientist awarded - DBT

Research Group Members

 M. Rajesh Kannan  J. Sridharan  K. Lakshmi Priya  N. Anantha Lakshmi  K. Mahesh  U. Devan  G. Nithya

Past Members 1. --

Details of Fellowships being availed by the Research Scholars/Project Staff S. No. Name Reg. No. Fellowship 1. Karthik S 6354 UGC – Project Fellow 2. Sankar R 44356 DST INSPIRE – SRF 3. Mohanraj S 4818 ICMR - JRF 4. Premkumar P 6403 DST – Project Fellow 5. Sivasangari B 4933 DBT – JRF 6. Sathya M 39336 UGC – Project Assistant 7. Karthick C 5195 CSIR – SRF 8. Balamurugan R 33504 UGC – Project Fellow 9. Selvaraju K 22214 CSIR - SRF 10. Varunkumar K 45376 DST – JRF ICMR - SRF 11. Anusha C 30014 URF – BDU 12. William James 42467 DST – PURSE 13. Sivapraksam 43854 NMPB - JRF 14. Vijayakumar R 42234 NMPB – SRF CSIR - SRF 15. Lakshmi Priya K 45375 DST – INSPIRE - SRF 16. Arun K 7905 URF – BDU ICMR - SRF 17. Sridharan J 32851 URF – BDU 18. Periyasamy S 47364 URF – BDU 19. Uma Maheswara Rao D 34407 UGC – RGNF – SRF 20. Saravanan K 34406 DST – SERB – JRF 21. Anantha Lakshmi N 7705 DST – (WOS – A) – PI 22. Mahesh Kumar K 7941 DBT – JRF 23. Palanimuthu DST – Post –Doc 24. Bhanupriya N 45145 DST – INSPIRE – JRF 25. Vennila S 29336 DST – WOS-A – SRF 26. Ravi C 32367 SERB – JRF 27. Roseline M 7868 URF – BDU 28. Nithya G 14727 URF – BDU 29. Subitha M 5486 URF - BDU 30. Prabhu S 25991 DST – PURSE II - JRF 31. Suhadha Parveen 25862 LADY TATA – JRF 32. Roshan 003280 DBT- JRF

Citations

Book Chapters (2013-14 to 2017-18)

1. Ravikumar V., Sankar. R. (2017), Preparation of Histone Deacetylase Inhibitor Vorinostat –Loaded Poly d, l-Lactide-co-Glycolide Polymeric Nanoparticles by Nanoprecipitation Method. In: Kramer O. (Eds.) HDAC/HAT Function Assessment and Inhibitor Development. Methods in Molecular Biology, Vol 1510. Hanuma Press, NewYork, NY, pp 399-403. ISBN: 978-1-4939-6525-0. 2. R Vilwanathan, A Chidambaram and R Kumar Chidambaram (2018), Pharmocoepigenetics: Novel mechanistic insights in drug discovery and development targeting chromatin modifying enzymes. In: Ramon Cacabelos (Eds). Pharmocoepigenetics, Vol 10. Academic Press, Elsevier, USA, ISBN: 978-0-12-18139394. 3. Divya Dasagrandhi, Arul Salomee Kamalabai R, Anusuyadevi Muthuswamy, Jayachandran Kesavan Swaminathan. (2018) Construction and Analysis of Protein-Protein Interaction Network: Role in Identification of Key Signaling Molecules Involved in a Disease Pathway. IGI Global Publishers. 4. Senthilkumar B, Senbagam B, Prahalathan C, Anbarasu K. Gateways of Pathogenic Bacterial Entry into Host Cells- Salmonella in a book ‘Pocket Guide to Bacterial Infections’ which is part of ‘Pocket Guide to Biomedical Scientists‟ by CRC Press. 2018: 59-71

Conferences/Workshops/Seminars Organized

S. No. Conferences/Workshops/Seminars Period

Evolutionary Trends in Biochemistry and Molecular th st st 20 & 21 Sep, 1. Biology – BIOTRENDS 2012 and 1 Annual Seminar on 2012 Awareness of Alzheimers‟s Disease – ALZINFO 2012

National Conference on Challenges and future prospects of th 2. 6 Feb, 2015 Applied research in Life Sciences Lecture Workshop on Hands on Training in Cell and 14th – 27th March 3. Molecular Biology Techniques 2018

Programmes offered

1. M. Sc. Biochemistry 2. M. Phil.Biochemistry 3. Ph. D. Biochemistry

M. Sc. Biochemistry

Program objectives

The objectives of M. Sc. Biochemistry programme are:

 PG Granduands are Professionally Competent with characteristic Knowledge-bank, Skill-set, Mind-set and Pragmatic Wisdom in their chosen fields.

 PG Granduands demonstrate the desired sense of being Seasoned and exhibit unequivocal Spiritedness with excellent qualities of productive contribution to society and nation in the arena Science and Technology.

 PG Graduands are mentored such that they exert Leadership Latitude in their chosen fields with commitment to novelty and distinction.

 PG Graduants are directed in understanding of ethical principles and responsibilities, moral and social values in day-to-day life thereby attaining Cultural and Civilized personality.

 PG Graduants of are able to Collate information from different kinds of sources and gain a coherent understanding of the subject.

Eligibility A candidate who has passed B.Sc. Degree Examination of Bharathidasan University with Biochemistry/ Chemistry / Zoology /Botany / Nutrition & Dietetics / Food Science/ Microbiology / Biotechnology as the Major subject or an examination of any other University accepted by the Syndicate of Bharathidasan University as equivalent to the B.Sc. degree examination of Bharathidasan University may be permitted to qualify for the M.Sc. Degree in Biochemistry by undergoing courses and appear for the examinations of this Department. A candidate for admission to the programme shall not be more than 25 years of age as on 1st July of the year of admission. Selection Procedure Selection will be made on the basis of merit list prepared from the Entrance exam and semester marks secured in UG degree.

M. Phil. Biochemistry

Program objectives

The objectives of M. Phil. Biochemistry programme are:

 To give the student adequate background for advanced research.  The M.Phil. Degree shall have the status of an intermediate degree between the Post-graduate degree and the Doctoral Degree.  It will have both research and course component.

Eligibility

Master‟s degree in relevant subject with a first class or minimum 60% marks (CGPA 6.5 on a 10 – point scale).

Selection Procedure

 Applications will be invited by open advertisement in all leading newspapers / local announcement for all categories of candidates Internal full-time Candidates: A candidate who wishes to work for M.Phil. degree on full time (including project staff working in sponsored projects being carried out at the institute) should apply in the prescribed form on or before due dates to be announced normally once every year.  Out of the applications received, the Schools will short-list the candidates to be called for written test / interview to be conducted at the institute on a pre-announced date.  Selection will be based on the overall merit index of the candidate which will be arrived at by taking into account the candidate‟s performance in the previous university examinations at Bachelor‟s and Master‟s level and the performance in the written test and / the interview. The weightages for arriving at the overall merit index will be as follows: Bachelor‟s degree – 20 % Master‟s degree – 20 % Written test and / Interview – 60 %

Students’ achievements (2013-14 to 2017-18) S. No. Reg. No. Name Exam(s) Qualified 1. 34034 D. Uma Maheswara Rao CSIR-UGC NET LS

Awards Received by students/scholars Year Name of the Awarded National Awards Students Name of the Award Awarding Institution 2010 R. Sankar DST -INSPIRE DST 2011 C. Kaarthick CSIR – SRF CSIR 2012 K. Lakshmi Priya DST -INSPIRE DST 2013 S. Rajakumar Rajiv Gandhi Fellowship UGC 2014 N. Anantha Lakshmi DST – WOS- A DST 2015 D. Uma Maheswara rao Rajiv Gandhi Fellowship UGC 2015 B. Sivasangari Best Paper Award in 6th Grand Chola Convention World Congress of Diabetes Centre, Chennai. 2015 K. Arun Best Poster awaid in 6th Grand Chola Convention World Congress of Diabetes Centre, Chennai. 2015 S. Mohanraj Best Paper Award in Central University of National Seminar. Tamil Nadu, Thiruvarur. 2015 Nishanthini Best Poster awaid in Bangalore. Bangalore India Bio 2015 17

2016 S. Vennila DST – WOS- A DST 2018 K. Arun ICMR – SRF ICMR 2018 K. Varunkumar ICMR – SRF ICMR

Foreign PDF received by scholars Name of the scholar Awarding institution Dr. K. Muthukumar Post Doctoral Fellow, National Jewish Health, Dencer – CO, USA. Dr. J. Sabarirajan Post Doctoral Fellow, National Jewish Health, Dencer – CO, USA. Dr. S. Shanmughapriya Post Doctoral Fellow, Temple University School of Philadelphia, PA 19140, USA. Dr. K. Selvaraju Post Doctoral Fellow, John Hopkins University, USA Dr. S. Karthik Prinicipal Research Scientist/ Engineer, Department of Medicine and health, Linkoping, Sweden. Dr. R. Sankar Post Doctoral Researcher, Food and animal Health Research Program, The Ohio State University, Ohio USA. Dr. S. Mohanraj Post Doctoral Fellow, John Hopkins University, USA Dr. C. Sivaprakasam Post Doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Cincinati, USA Dr. A. William James Post Doctoral Fellow, Diabetes and Obesity Research Center, Winthrop University Hospital, USA. Dr. S. Rajakumar Post Doctoral Fellow, Department of Pediatrics, University of Alberta, Canada Dr. P. Moorthi Post Doctoral Fellow, Department of Neurobiology, University of Chicago, USA Dr. C. Karthick Post Doctoral Fellow, Temple University School of Philadelphia, PA 19140, USA. Dr. M. Sathya Post Doctoral Researcher, Department of Neurobiology, Care Sciences and Society – NVS, Karolinska Institutet, Sweden. Dr. R. Balamurugan Post Doctoral Fellow, School of Medicine, Vanderbilt University, USA. Abhishek Raj Post Doctoral Fellow, R. Vijayakumar Post Doctoral Fellow, C Karthick Post Doctoral Fellow, Temple University, USA Moorthi Ponnusamy Post Doctoral Fellow, University of Chicago, USA Premkumar P Post Doctoral Fellow, National Brain Research Institute, India Sathya M Post Doctoral Fellow, Karolinska University, Sweden

Ph. D. Awardees M. Sc. Gold Medalists Name Year of passing Name Year of passing P. Vijayaraj 2011 Shobana Pandian 2011 N. Karpagam 2011 Ajitha 2012 K. Muthukumar 2011 P Kirijayini 2013 J. Sabarirajan Uma Maheshwari 2012 2015 Nallal K. Jyothi 2013 Silpa Sasi 2016 S. Shanmughapriya 2013 D. Kalyani 2014 K. Selvaraju 2014 S. Karthik 2014 R. Sankar 2015 V. Vishnu varthini 2015 C. Sivaprakasam 2015 S. Mohanraj 2015 B. Sivasangari 2016 S. Rajakumar 2016 A. William James 2017 R. Balamurugan 2017 P. Premkumar 2017 M. Sathya 2017 P. Moorthi 2018 Abhishek Raj 2018 C. Karthick 2018 R. Vijayakumar 2018 19

Facilities

Real Time PCR -80 Deg Deep Freezer

UV Visible Spectrophotometer CO2 Incubator

Laminar Air Flow Cold Room Facility 20

Computer Facility (DST-FIST) Department Library

Conferences, Seminars and Workshop Organised

National Conference “Evolutionary trends in National Conference on Challenges and Biochemistry and molecular future prospects of applied research in life biology(“BIOTRENDZ-2012”) &I Annual seminar science (NCCFPARLS – 2016) on Alzheimer’s disease(ALZINFO-2012)”

Clean and Green Initiative - 2018 World Food Day – October 2018

Workshop on “Hands on Training Cell and Molecular Biology Tachniques – March „2018”

Departmental Activities Screening of Dementia subjects among Aged Biochallenger‟s Club population of Dharmapuri District

Dr. Vasanthi Nachiappan Professor and Head Department of Biochemistry Bharathidasan University Tiruchirappalli -620 024 Tamil Nadu, India Tel: +91 431 –2407071 Ext 631 Fax:+91 431- 2407045 E-Mail: [email protected] www.bdu.ac.in

Research & Consultancy Projects Completed Projects

S. Principal Project Title Period Funding Amount No. Investigator From To Agency ₹ (in lakhs) 1. Dr. Vasanthi Remodeling of fatty acid in 2008 2011 UGC 10.89 Nachiappan phosphatidyl choline rat liver as a model system 2. Dr. Vasanthi Endoplasmic reticulum (ER) 2012 2015 CSIR 22.92 Nachiappan stress induced autophagy in Saccharomyces cerevisiae and the implication in Phospholipid. 3. Dr. Vasanthi Characterization of active 2013 2017 NMPB 23.52 Nachiappan principle from Cassia auriculata as a potential drug for hyperlipidemia and cardiovascular disease 4. Dr. M. Identification of the Intracellular 2012 2015 UGC 13.48 Anusuyadevi localization of α, β and γ secretase Jayachandran and APP cleavage pattern in young and aged rat brain region: an understanding towards the underlying mechanism behind AD pathology. 5. Dr. M. Hyperinsulinemia influences 2013 2016 ICMR 50 Anusuyadevi autophagy and mitochondrial Jayachandran biogenesis: A possible mechanism of neuronal ageing. 6. Dr. C. Evaluation of the Effect of Acute 2011 2014 DBT 21.63 Prahalathan Inflammation on Histone H3 Modifications in Rat Testis and Its Implications in Testicular Steroidogenesis 7. Dr. C. A Study on Proinflammatory 2011 2014 ICMR 20.15 Prahalathan Cytokines Mediated Histone H3 Modifications in R2C Leydig Cells and Its Implications in Regulation of Testicular Steroidogenesis 8. Dr. C. Evaluation of the Effect of Acute 2011 2014 UGC 13.17 Prahalathan Inflammation on Histone H3 Modifications in Rat Pancreas and Its Implications in Insulin Gene Transcription 9. Dr. C. Role of Class II Histone 2012 2015 DST 16.70 Prahalathan Deacetylases in Regulation of Insulin Gene Transcription 10. Dr. V. Nano encapsulation of 2011 2014 UGC 11.14 Suberoylanilide hydroxamic acid 24

Ravikumar (SAHA): an attempt to improve anticancer activity in non-small cell lung cancer cell lines. 11. Dr. V. Synergistic Interaction Of The 2012 2015 DST 22.75 Ravikumar Histone Deacetylase Inhibitor With The Proteasome Inhibitor In Lung Cancer. 12. Dr. A. Molecular characterization of 2012 2015 UGC 13.92 Antony Constitutive and Consensus Joseph miRNA Expression Profiles in Velanganni NCI-60 Panel of Human Cancer Cell Lines 13. Dr. A. Exploration of hTERT gene 2014 2017 DST- 24.13 Antony inhibition in cervical cancer cells (WOS- Joseph by nanoencapsulated hTERT- A) Velanganni siRNA 14. Dr. A. RNAi mediated Functional 2015 2018 DBT 25.00 Antony Analysis of RNA induced Joseph Silencing Complex (RISC) and its Velanganni Component AEG-1 that induce the Expression of Transcription Factor LSF in Hepatocellular Carcinoma

Ongoing Projects

S. Principal Project Title Period Funding Amount No. Investigator From To Agency ₹ (in lakhs) 1. Dr. Vasanthi High throughput screening & 2017 2020 SERB 47.92 Nachiappan molecular analysis of GCR1 transcription factor and its impact on the binding motif of OPI3 promoter in Saccharomyces cerevisae 2. Dr. M. Assessment of the effect of aspirin 2017 2020 SERB 52.00 Anusuyadevi treatment on neural stem cells and Jayachandran the regulation of hippocampal neurogenesis in the adult brain of the experimental rodents: A non-invasive attempt for the brain regeneration 3. Dr. C. Elucidation of the role of SIRT4 in 2018 2021 SERB 38.20 Prahalathan testicular steroidogenesis 4. Dr. V. Investigation on acetylation 2016 2019 SERB 28.99 Ravikumar dependent activation of Notch signaling pathway by HDAC inhibitors - A possible mechanism for drug resistance and survival upon HDAC inhibition therapy in NSCLC cell lines 5. Dr. A. Social Support and Reproductive 2017 2019 ICMR- 13.75 Antony Autonomy of Visually Challenged ICSSR Joseph Women in the Rural Districts of Velanganni Tamil Nadu 26

Collaborative Project

Agency Period Project Title Budget S. (Rs. In No From To lakhs) Characerization Of Active Principles From 23.52 1 NMPB 2012 2015 Cassia Auriculata As A Potential Drug For Hyperlilpidemia And Cardiovascular Diseases Endoplasmic reticulum stress induced 22.92 2 CSIR 2012 2015 autophagy in Saccharomyces cerevisiae and the implications in phospholipids Studies on Potential Oncogenic Role of the 27.07 Transcription Factor Nsep1 Association with 3 DBT 2012 2015 the Overexpressed Rps27a in Human Hepatocellular Carcinoma (HCC) Novel MASP-2 inhibitor from Indian 16.00 4 CSIR 2012 2015 medicinal plants for protection against myocardial infraction Structural Exploration of Recombinant Mouse 5 DBT 2012 2016 29.87 Seminal Vesicle Spink-3 Receptor on Sperm Assessment of the effect of aspirin treatment 52.00 on neural stem cells and the regulation of 6 SERB 2018 2021 hippocampal neurogenesis in the adult brain of the experimental rodents: A non-invasive attempt for the brain regeneration . 27

List of Research Publications since 2013 to 2018

1. Anandhi R, Annadurai T, Anitha TS, Muralidharan AR, Najmunnisha K, Nachiappan V, Thomas PA, Geraldine (2013). Antihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom, Pleurotus ostreatus, and its major constituent, chrysin, in Triton WR- 1339-induced hypercholesterolemic rats. J Physiol Biochem. 69(2):313-23. doi: 10.1007/s13105- 012-0215-6.

2. Shanmughapriya S, Nachiappan V, Natarajaseenivasan K (2013) BRCA1 and BRCA2 mutations in the ovarian cancer population across race and ethnicity: special reference to Asia. Oncology. 84(4):226-32. doi: 10.1159/000346593.

3. Muthukumar K, Nachiappan V. (2013) Phosphatidylethanolamine from phosphatidylserine decarboxylase2 is essential for autophagy under cadmium stress in Saccharomyces cerevisiae. Cell Biochem Biophys. 67(3):1353-63. doi: 10.1007/s12013-013-9667-8.

4. Muthusamy K, Singh KhD, Chinnasamy S, Nagamani S, Krishnasamy G, Thiyagarajan C, Premkumar P, Anusuyadevi M. High throughput virtual screening and E-pharmacophore filtering in the discovery of new BACE-1 inhibitors. Interdiscip Sci. 2013 Jun;5(2):119-26.

5. Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity. Sankar R, Karthik A, Prabu A, Karthik S, Shivashangari KS, Ravikumar V, Colloids and Surfaces B: Biointerfaces. 108:80-84, 2013.

6. Vishnu Varthini L Selvaraju K, Srinivasan M, Nachiappan V. (2014) ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae. FEBS Lett. pii: S0014-5793(14)00824-2. doi: 10.1016/j.febslet.2014.11.019.

7. Selvaraju K, Rajakumar S, Nachiappan V. (2014) Identification of a phospholipase B encoded by the LPL1 gene in Saccharomyces cerevisiae. Biochim Biophys Acta. 1841(10):1383-1392. doi: 10.1016/j.bbalip.2014.06.013

8. Vijayaraj P, Sivaprakasam C, Varthini LV, Sarkar M, Nachiappan V. (2014) In vitro exposure of tobacco specific nitrosamines decreases the rat lung phospholipids by enhanced phospholipase A2 activity. Toxicol In Vitro. 28(6):1097-105. doi: 10.1016/j.tiv.2014.05.001.

9. Kalyani D, Jyothi K, Sivaprakasam C, Nachiappan V. (2014) Spectroscopic and molecular modeling studies on the interactions of N-Methylformamide with superoxide dismutase. Spectrochim Acta A Mol Biomol Spectrosc. 124:148-52. doi: 10.1016/j.saa.2014.01.013

10. James AW, Nachiappan V. (2014) Phosphate transporter mediated lipid accumulation in Saccharomyces cerevisiae under phosphate starvation conditions.Bioresour Technol. 151:100-5. doi: 10.1016/j.biortech.2013.10.054

11. Kannan A, Prahalathan C. Effect of hyperglycaemia on the expression of aquaporins in diabetic rat testis. Diabetologia. 2014:57;s535-36.

12. Sadasivam M, Ramatchandirin B, Balakrishnan S, Selvaraj K, Prahalathan C. The role of phosphoenolpyruvate carboxykinase in neuronal steroidogenesis under acute inflammation. Gene. 2014;552:249-54.

13. Balakrishnan S, Sadasivam M, Kannan A, Selvam AP, Prahalathan C. Glucose modulates Pax6 expression through the JNK/p38 MAP kinase pathway in pancreatic beta-cells. Life Sci. 2014;109:1-7.

14. Sadasivam M, Ramatchandirin B, Ayyanar A, Prahalathan C. Bacterial lipopolysaccharide differently modulates steroidogenic enzymes gene expressions in brain and testis in rats. Neurosci Res. 2014;83:81-8.

15. Biocompatibility and biodistribution of suberoylanilide hydroxamic acid loaded poly (DL- lactide-co-glycolide) nanoparticles for targeted drug delivery in cancer. Sankar R, Ravikumar V. Biomedicine & Pharmacotherapy 68 (2014) 865–871, 2014.

16. Growth inhibition of bloom forming cyanobacterium Microcystis aeruginosa by green route fabricated copper oxide nanoparticles. Sankar R, Balaji Prasath B, Nandakumar R, Santhanam P, Shivashangari KS, Ravikumar V, Journal of Environmental and Pollution Research DOI 10.1007/s11356-014-3362-1, 2014.

17. Anticancer activity of Ficus religiosa engineered copper oxide nanoparticles. Sankar R, Maheswari R, Karthik S, Shivashangari KS, Ravikumar V, Materials Science and Engineering C 44 (2014) 234–239, 2014.

18. Wound healing activity of Origanum vulgare engineered titanium dioxide nanoparticles in wistar -albino rats. Sankar R, Dhivya R, Shivashangari KS, Ravikumar V, J Mater Sci Mater Med. 25, 1701-1708, 2014.

19. Green synthesis of colloidal copper oxide nanoparticles using Carica papaya and its application in photocatalytic dye degradation. Sankar R, Manikandan P, Malarvizhi V, Fathima T, Shivashangari KS, RavikumarV, Spectrochim Acta A Mol Biomol Spectrosc. 121:746-50, 2014.

20. Anbazahan SM, Shanthi Mari LS, Yogeshwari G, Jagruthi C, Thirumurugan R, Arockiaraj J, A. Antony Joseph Velanganni, Krishnamoorthy P, Balasundaram C, Harikrishnan R (2014). Immune Response and Disease Resistance of Carotenoids Supplementation Diet in Cyprinus Carpio against Aeromonas Hydrophila. Fish Shellfish Immunol. Jun 20;40(1):9-13.

21. Sivaprakasam C, Nachiappan V. (2015) Modulatory effect of cadmium on the expression of phospholipase A2 and proinflammatory genes in rat testis. Environ Toxicol. doi: 10.1002/tox.22124.

22. Moorthi, P., Premkumar, P., Priyanka, R., Jayachandran, K. S., Anusuyadevi, M. Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: Positive clue toward SAD. Neuroscience. 2015 Jun 1;301:90-105.

23. Sadasivam M, Ramatchandirin B, Balakrishnan S, Prahalathan C. TNF-α mediated suppression of Leydig cell steroidogenesis involves DAX-1. Inflammation Res. 2015;64:549-56.

24. Sadasivam M, Ramatchandirin B, Balakrishnan S, Prahalathan C. HDAC7 modulates TNF-α mediated suppression of Leydig cell steroidogenesis. Mol Cell Biochem. 2015;406:83-90.

25. Inhibition of pathogenic bacterial growth on excision wounds by green synthesized copper oxide nanoparticles leads to accelerated wound healing activity in Wistar Albino rats. R. Sankar, A. Baskaran, K.S. Shivashangari, V. Ravikumar, J Mater Sci Mater Med. 26:214, 2015.

26. Chemopreventive potential of fungal taxol against 7, 12-dimethylbenz[a]anthracene induced mammary gland carcinogenesis in Sprague Dawley rats. Kathamuthu Gokul Raj, Ranganathan Chidambaram, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Mohan Pandi. Eur J Pharmacol. Nov 15; 767:108-18, 2015.

27. Single and double chain surfactant–cobalt (III) complexes: the impact of hydrophobicity on the interaction with calf thymus DNA, and their biological activities. Selva kumar Veeralakshmi selvan Nehru, Gopal Sabapathi, Sankaralingam Arunachalam, Ponnambalam Vennuvanalingam, Ponnuchamy Kumar, Chidambaram Anusha, Vilwanathan Ravikumar. RSC Adv., 2015, 5, 31746-31758, 2015.

28. Nanostructured delivery growth system for suberoylanilide hydroxamic acid against lung cancer cells. Sankar R, Karthik S, Subramanian N, Venkateshwaran K, Sonnemann J, Ravikumar V. Materials Science and Engineering: C. Volume 51, 1 June 2015, Pages 362–368, 2015.

29. Krishnamoorthy Lakshmi Priya and Arockiam Antony Joseph Velanganni (2015). Therapeutic potential of doxorubicin loaded poly (d, l-lacticco-glycolic acid) against p- dimethylaminoazobenzene induced liver cancer. Int. J. Phar. and Bio Sci. 6(4):511- 521.(IF:0.36).

30. Selvaraj Rajakumar and Vasanthi Nachiappan (2016) Lipid droplets alleviate cadmium induced cytotoxicity in Saccharomyces cerevisiae. Received 4th May 2016 , Accepted 3rd October 2016. DOI: 10.1039/C6TX00187D (Paper) Toxicol. Res., 2017, 6, 30-41.

31. Kannan M, Sivaprakasam C, Prinz WA, Nachiappan V (2016) Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1959-1967. doi: 10.1016/j.bbalip.2016.09.015.

32. James AW, Gowsalya R, Nachiappan V (2016) Dolichyl pyrophosphate phosphatase-mediated N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae. Biochim Biophys Acta.1861(11):1705-1718. doi: 10.1016/j.bbalip.2016.08.004. [Epub ahead of print]

33. Rajakumar S, Bhanupriya N, Ravi C, Nachiappan V (2016) Endoplasmic reticulum stress and calcium imbalance are involved in cadmium-induced lipid aberrancy in Saccharomyces cerevisiae. Cell Stress Chaperones.21(5):895-906. doi: 10.1007/s12192-016-0714-4. Epub 2016 Jun 25.

34. Raj A, Nachiappan V (2016) Exposure to benzene metabolites causes oxidative damage in Saccharomyces cerevisiae. Antonie Van Leeuwenhoek. 109(6):841-54. doi: 10.1007/s10482- 016-0684-7. Epub 2016 Mar 25.

35. Rajakumar S, Ravi C, Nachiappan V (2016) Defect of zinc transporter ZRT1 ameliorates cadmium induced lipid accumulation in Saccharomyces cerevisiae. Metallomics. 8(4):453-60. doi: 10.1039/c6mt00005c. Epub 2016 Mar 21.

36. Selvaraju K, Gowsalya R, Vijayakumar R, Nachiappan V (2016) MGL2/YMR210w encodes a monoacylglycerol lipase in Saccharomyces cerevisiae. FEBS Lett. 590(8):1174-86. doi: 10.1002/1873-3468.12136.

37. Sathya, M., Moorthi, P., Premkumar, P., Kandasamy, M., Jayachandran, K. S., Anusuyadevi, M. Resveratrol intervenes cholesterol and isoprenoids mediated amyloidogenic processing of AβPP in Familial Alzheimer‟s disease. Journal of Alzheimer's Disease Preprint (2016): 1-22.

38. Karthick, C., Periyasamy, S., Jeyachandran, K. S., Anusuyadevi, M. Intrahippocampal Administration of Ibotenic Acid Induced Cholinergic Dysfunction via NR2A/NR2B Expression: Implications of Resveratrol against Alzheimer Disease Pathophysiology. Front Mol Neurosci 2016, 9:28.

39. Ramatchandirin B, Sadasivam M, Kannan A, Prahalathan C. Sirtuin4 regulates lipopolysaccharide mediated Leydig cell dysfunction J Cell Biochem. 2016;117:904-16.

40. Kalaiarasi, A., Anusha, C., Sankar, R., Rajasekaran, S., John Marshal, J., Muthusamy, K., &Ravikumar, V. (2016). Plant isoquinoline alkaloid berberine exhibits chromatin remodeling by modulation of histone deacetylase to induce growth arrest and apoptosis in the A549 cell line. Journal of agricultural and food chemistry, 64(50), 9542-9550.

41. Mathuram, T. L., Ravikumar, V., Reece, L. M., Karthik, S., Sasikumar, C. S., & Cherian, K. M. (2016). Tideglusib induces apoptosis in human neuroblastoma IMR32 cells, provoking sub- G0/G1 accumulation and ROS generation. Environmental toxicology and pharmacology, 46, 194-205.

42. Ramalingam, V., Varunkumar, K., Ravikumar, V., & Rajaram, R. (2016). Development of glycolipid biosurfactant for inducing apoptosis in HeLa cells. RSC Advances, 6(68), 64087- 64096.

43. Gunasekaran VP, Nishi K, Ravikumar V and Mathan G. Nuclear shuttling of Y-box binding protein 1, its clinical relevance to cancer and as a therapeutic target. Bangladesh J Pharmacol, 11: 501-24.

44. Marine steroid derived from Acropora formosa enhances mitochondrial- mediated apoptosis in non- small cell lung cancer cells. Ramalingam Vaikundamooorthy, Revathidevi Sundramoorthy, Varunkumar Krishnamoorthy, Ravikumar Vilwanathan, Rajaram Rajendran. Tumor Biol, DOI 10.1007/s13277-016-4947-8, 2016.

45. Renu Sankar, Kanchi Subramanian Shivashangari, Vilwanathan Ravikumar. Integrated poly- D,L-lactide-co-glycolide/silver nanocomposite: synthesis, characterization and wound healing potential in Wistar Albino rats. RSC Advances.2016.

46. Sridharan Jeyamohan, Rajesh Kannan Moorthy, Mahesh Kumar Kannan, Antony Joseph Velanganni Arockiam (2016). Parthenolide induces apoptosis and autophagy through the 31

suppression of PI3K/Akt signaling pathway in cervical cancer. Biotechnol. Lett. 38(8):1251- 1260.

47. Vijayakumar, R., &Nachiappan, V. (2017). Cassia auriculata flower extract attenuates hyperlipidemia in male Wistar rats by regulating the hepatic cholesterol metabolism. Biomedicine & Pharmacotherapy, 95, 394-401.

48. Rajendran, V., Krishnegowda, A., &Nachiappan, V. (2017). Antihyperlipidemic activity of Cassia auriculata flower extract in oleic acid induced hyperlipidemia in Saccharomyces cerevisiae. Journal of food science and technology, 54(9), 2965-2972.

49. Divya, D., Arul Salomee, K. R., Anusuyadevi, M., Jayachandran, K. S.. "HMGB1: A Therapeutic Target for Myocardial Infarction." Cardiovasc Ther 7, no. 5 (2017): 555724.

50. Periyasamy, S., Sathya, M., Karthick, C., Kandasamy, M., Shanmugaapriya, S., Tamilselvan, J., Jayachandran, K. S., Anusuyadevi, M. Association studies of specific Cholesterol related genes (APOE, LPL, and CETP) with Lipid profile and memory function: A correlative study among Rural and Tribal Population of Dharmapuri District, India. J Alzheimers Dis. 2017 (doi: 10.3233/JAD-170272).

51. Velusamy, T., Panneerselvam, S. A., Purushottam, M., Anusuyadevi, M., Pal, P. K., Jain, S., Essa, M. M., Guillemin, J. G., Kandasamy, M. Protective effects of antioxidants on neuronal dysfunction and plasticity in Huntington‟s disease. Oxidative medicine and cellular longevity, 2017.

52. Sankar, R., Rahman, P. K., Varunkumar, K., Anusha, C., Kalaiarasi, A., Shivashangari, K. S., &Ravikumar, V. (2017). Facile synthesis of Curcuma longa tuber powder engineered metal nanoparticles for bioimaging applications. Journal of Molecular Structure, 1129, 8-16.

53. Theodore Lemuel Mathuram, Vilwanathan Ravikumar, Lisa M. Reece, Changam Sheela Sasikumar, Kotturathu Mammen Cherian (2017). Correlative Studies Unravelling the Possible Mechanism of Cell Death in Tideglusib-Treated Human Ovarian Teratocarcinoma-Derived PA-1 Cells. Journal of Environmental Pathology, Toxicology and Oncology, 36(4):321–344.

54. Gnanasekar, Sathishkumar, Jeyaraj Murugaraj, Balakrishnan Dhivyabharathi, Varunkumar Krishnamoorthy, Pradeep K. Jha, Prabukumar Seetharaman, Ravikumar Vilwanathan, and Sivaramakrishnan Sivaperumal. (2017) "Antibacterial and cytotoxicity effects of biogenic palladium nanoparticles synthesized using fruit extract of Couroupita guianensis Aubl." Journal of Applied Biomedicine, 16(1), 59-65.

55. Anusha, C., Sankar, R., Varunkumar, K., Sivasindhuja, G., &Ravikumar, V. (2017). Fourier transform-infrared spectroscopy as a diagnostic tool for mosquito coil smoke inhalation toxicity in Swiss Albino mice. Journal of Molecular Structure, 1149, 128-135.

56. Chidambaram, A., Sekar, A., Kavya, S. H., Chidambaram, R. K., Arunachalam, K., Senthilkumar, G. P., &Vilwanathan, R. (2017). Synthesis, characterization, and evaluation of Cd [L-proline] 2, a novel histone deacetylase inhibitor that induces epigenetic modification of histone deacetylase isoforms in A549 cells. Investigational new drugs, 35(6), 691-705.

57. Thangavel Kavinkumar, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Sellaperumal Manivannan. Anticancer activity of graphene oxide-reduced graphene oxide-silver nanoparticle composites. Journal of Colloid and Interface Science; 2017, 505, 1125-1133.

58. Ganesan Nithya, Umapathy Devan, Kannan Mahesh Kumar, Arockiam Antony Joseph Velanganni (2017). A review on the role of Astrocyte Elevated Gene-1 in cancer. Int J Phar Sci and Res. 8(3): 975-984.

59. Moorthy Rajesh Kannan, Jeyamohan Sridharan, Nagapoosanam Anantha Lakshmi, Arockiam Antony Joseph Velanganni (2017). Identification and characterization of evolutionary conserved miRNAs in various types of cancer: in silico and experimental approach. RJLBPCS 3(4): 70-89.

60. Karthick C, Nithiyanandan S, Essa MM, Guillemin GJ, Jayachandran SK, Anusuyadevi M. Time-dependent effect of oligomeric amyloid-β (1-42)-induced hippocampal neurodegeneration in rat model of Alzheimer's disease. Neurol Res. 2018 Nov 19:1-12. doi: 10.1080/01616412.2018.1544745.

61. Divya Dasagrandhi, Arul Salomee Kamalabai R, Anusuyadevi Muthuswamy, Angela Marie Lennox ,Tamilselvan Jayavelu, Vasudharani Devanathan, Jayachandran Kesavan Swaminathan. Ischemia/reperfusion injury in male guinea pigs: An efficient model to investigate myocardial damage in cardiovascular complications. Biomedicine & Pharmacotherapy 20, February 2018.

62. Sathya, M., Gobinath, T., Salomy, A., Nisha, M., Kandasamy, M., Essa, M. M., Jayachandran, K. S., Anusuyadevi, M. Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer‟s disease. Frontiers In Bioscience, Landmark, 23, 1380-1390, March 1, 2018.

63. Pattarayan, D., Thimmulappa, R. K., Ravikumar, V., & Rajasekaran, S. (2018). Diagnostic potential of extracellular microRNA in respiratory diseases. Clinical reviews in allergy & immunology, 54(3), 480-492.

64. Ramalingam, V., Varunkumar, K., Ravikumar, V., & Rajaram, R. (2018). p53 mediated transcriptional regulation of long non-coding RNA by 1-hydroxy-1-norresistomycin triggers intrinsic apoptosis in adenocarcinoma lung cancer. Chemico-biological interactions, 287, 1-12.

65. Ramalingam, V., Varunkumar, K., Ravikumar, V., & Rajaram, R. (2018). Target delivery of doxorubicin tethered with PVP stabilized gold nanoparticles for effective treatment of lung cancer. Scientific reports, 8(1), 3815.

66. Vaikundamoorthy, R., Krishnamoorthy, V., Vilwanathan, R., & Rajendran, R. (2018). Structural characterization and anticancer activity (mcf7 and mda-mb-231) of polysaccharides fractionated from brown seaweed sargassum wightii. International journal of biological macromolecules, 111, 1229-1237.

67. Kalaiarasi, A., Sankar, R., Anusha, C., Saravanan, K., Aarthy, K., Karthic, S., &Ravikumar, V. (2018). Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase. Biotechnology letters, 40(2), 249-256.

68. Chidambaram, A., Sundararaju, K., Chidambaram, R. K., Subbiah, R., Jayaraj, J. M., Muthusamy, K., &Vilwanathan, R. (2018). Design, synthesis, and characterization of α, β‐unsaturated carboxylic acid, and its urea based derivatives that explores novel epigenetic modulators in human non‐small cell lung cancer A549 cell line. Journal of cellular physiology, 233(7), 5293-5309.

69. Nithya Ganesan, Devan Umapathya and Antony Joseph Velanganni Arockiam (2018). LXR- α/ABCA1 pair enhances and deregulates VEGF modulated by diosgenin in liver cancer cell line (Huh-7). Int J Pharm Biol Sci., 8 (4): 573-579

70. Nagapoosanam Anantha Lakshmi, Umapathy Devan, Moorthy Rajesh Kannan, Arockiam Antony Joseph Velanganni. Knockdown of human Telomerase Reverse Transcriptase induces apoptosis via Bax/Caspase-3 dependent pathway in cervical cancer. Indian J Med Res. (Accepted for publication).

COURSE STRUCTURE

M.Sc. BIOCHEMISTRY

SEM Category Code Courses Hrs Crs CIA ESE TOTAL Marks Marks Marks Core 1 BC101 Biomolecules 6 6 25 75 100

I Core 2 BC102 Enzymes 6 6 25 75 100

Core 3 BC103 Cell and Molecular Biology 6 6 25 75 100

Core 4 BC104 Biochemical Techniques 6 6 25 75 100

Core 5 BC105 Laboratory Courses-I 6 4 40 60 100

Total for Semester-I 30 28 140 360 500

Core 6 BC 201 Biochemistry of Signal 6 6 25 75 100 II Transduction & Regulation Core 7 BC 202 Intermediary Metabolism 6 6 25 75 100

Elective BC 203 Elective- I 5 3 25 75 100

Core 8 BC 204 Laboratory Courses –II 6 4 40 60 100

Non major BC2ED ED-I 3 2 25 75 100 Elective Total for Semester II 26 21 140 360 500 Core 9 BC 301 Immunology 6 6 25 75 100

Core 10 BC 302 Genetic Engineering and 6 6 25 75 100 III Molecular Techniques Elective BC 303 Elective - II 5 3 25 75 100

Core 11 BC 304 Laboratory Courses -III 6 4 40 60 100

Non major BC3ED ED-II 3 2 25 75 100 Elective Total for Semester III 26 21 140 360 500

BC 401 Project & Viva Voice 30 20 100

IV Total for Semester IV 30 20 100

Total hours & credits 112 90 1600

ELECTIVE COURSES

BC203 Ecology and Environmental Biology BC205 Bioinformatics BC206 Biostatistics BC207 Chromatin and Epigenetics BC303 Clinical Biochemistry BC305 Membrane Biochemistry BC306 Concept in Neurochemistry

NON MAJOR ELECTIVE COURSES BC3ED Developmental Biology BC2ED Genetics BC3ED-I Computational Biology

M.Phil. BIOCHEMISTRY

Sem no Subject Subject title Hrs./week credits Internal External total code mark mark I BCMPH01 Research 6 4 25 75 100 Methodology I BCMPH02 Principles 6 4 25 75 100 and Applications of Molecular techniques I BCMPH03 Guide paper 6 4 25 75 100 I BCMPH04 Teaching 6 4 25 75 100 and Learning skills II --- Dissertation 6 months 8 50 150 200 and Viva Voce Total 24 600