November 14 - 17, 2018 Venice, Italy

Chairpersons: Gian Carlo Di Renzo (Italy), Roberto Romero (USA) Choose the right journal to submit your paper

Editor-in-Chief E. Gratacós, Barcelona Fetal Diagnosis and Therapy 2018: Volume 43, 44 4 issues per volume Language : English ISSN : 1015–3837 (print) e-ISSN : 1421–9964 (online) www.karger.com/fdt

Review 259 Low Necroptosis Process Predicts Poor Treatment Outcome of Human Papillomavirus Positive Cervical Cancers by 209 Platinum-Based Neoadjuvant Chemotherapy versus Primary Decreasing Tumor-Associated Macrophages M1 Polarization Surgery in Ovarian Carcinoma International Federation of Li, L.; Yu, S.; Zang, C. (Beijing) Gynecology and Obstetrics Stages IIIc and IV: A Systematic Review and Meta-Analysis 268 Survival Rates in Closed and Open Vitrification for Editor-in-Chief Xiao, Y.; Xie, S.; Zhang, N.; Wang, J.; Lv, C.; Guo, J.; Yang, Q. (Shenyang) Human Mature Oocyte Cryopreservation: A Meta-Analysis Youm, H.S.; Choi, J.-R.; Oh, D.; Rho, Y.H. (Busan) Narrative Review 275 Shifting from Oral Contraceptives to Norethisterone Acetate, or Vice Versa, because of Drug Intolerance: Does the Change 220 Serous Carcinoma of the Uterine Cervix, an Extremely Rare Benefit Women with Endometriosis? T.M. D‘Hooghe, Leuven Aggressive Entity: A Literature Review Vercellini, P.; Ottolini, F.; Frattaruolo, M.P.; Buggio, L.; Roberto, A.; Jonska-Gmyrek, J.; Zolciak-Siwinska, A.; Gmyrek, L.; Michalski, W.; Somigliana, E. (Milan) Poniatowska, G.; Fuksiewicz, M.; Wiechno, P.; Kucharz, J.; Kowalska, M.; Kotowicz, B. (Warsaw) 285 Clinical Application of Quantitative Foetal Fibronectin for the Prediction of Preterm Birth in Symptomatic Women Radford, S.K. (Parkville, VIC); Da Silva Costa, F. (Clayton, VIC); Original Articles Araujo Júnior, E. (São Paulo); Sheehan, P.M. (Parkville, VIC) 227 Efficacy and Safety of Hyaluronic Acid Gel for the Prevention 290 Does Age-Adjusted Charlson Comorbidity Score Impact Gynecologic and of Intrauterine Adhesion: A Meta-Analysis of Randomized Survival Endpoints in Women with Federation of Clinical Trials Gynecology and Obstetrics-Stage III Endometrial Cancer? Liu, H.; Xu, Y.; Yi, N.; Yi, W. (Beijing) Ghanem, A.I.; Modh, A.; Burmeister, C.; Munkarah, A.R.; Elshaikh, M.A. (Detroit, MI) 234 Evaluating Colposcopy with Dynamic Spectral Imaging During Routine Practice at Five Colposcopy Clinics in Wales: 299 Checkpoint Kinase 1 Is Overexpressed during Clinical Performance Obstetric Investigation HPV16-Induced Cervical Carcinogenesis Budithi, S.; Peevor, R. (Bangor); Pugh, D. (Llantrisant); Papagiannakis, E.; Lin, W.; Chen, S. (Wenzhou) Durman, A. (Edinburgh); Banu, N. (Boddelwyddan); Alalade, A. (Wrexham); Leeson, S. (Bangor) 306 Evaluation of the Efficacy of Ultrasound-Guided Local Lauromacrogol Injection Combined with Aspiration for 241 Wilms’ Tumor 1 Overexpression in Granulosa Cells Is Cesarean Scar Pregnancy: A Novel Treatment 2018: Volume 83 Associated with Polycystic Ovaries in Polycystic Ovary Chai, Z.-Y.; Yu, L.; Liu, M.-M.; Zhu, T.-W.; Qi, F. (Linhai) Syndrome Patients Wang, Q.; Huang, T.; Shu, X.; Zhao, S.-G. (Jinan); Liang, Y. (Shanghai); Muhammad, T. (Jinan); Gao, F. (Beijing); Zhao, H.; Liu, H.-B. (Jinan) 247 The Effects of Heat Exposure on Vaginal Smooth Muscle 6 issues per volume Cells: Elastin and Collagen Production Kozma, B. (Debrecen); Candiotti, K. (Miami, FL); Póka, R. (Debrecen); Takács, P. (Debrecen/Norfolk) 252 Relationship between the von Willebrand Factor Plasma Concentration and Ultrasonographic Doppler Findings Language : English in Pregnancies Complicated by Hypertensive Disorders: A Pilot Study Szpera-Gozdziewicz, A.; Gozdziewicz, T.; Boruczkowski, M. (Poznan); Dworacki, G.; Breborowicz, G.H. (Poznan) ISSN : 0378–7346 (print) e-ISSN : 1423–002X (online) www.karger.com/goi

Listed in bibliographic services, including: PubMed/MEDLINE, Web of Science, Google Scholar, Scopus, Embase

S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland)

KI18341 Medical and Scientific Publishers E-Mail : [email protected] November 14 - 17, 2018| Venice, Italy Choose the right journal to submit your paper INDEX

Editor-in-Chief Welcome Letter 4 E. Gratacós, Barcelona How to download the congress APP 5 Fetal Diagnosis and Therapy 2018: Volume 43, 44 General Information 6 4 issues per volume Language : English Wednesday, 14th November ISSN : 1015–3837 (print) 10 e-ISSN : 1421–9964 (online) Thursday, 15th November 23 www.karger.com/fdt Friday, 16th November 27

Saturday, 17th November 31

Supporters 36

Listed in bibliographic services, including: PubMed/MEDLINE, Web of Science, Google Scholar, Scopus, Embase

S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland)

KI18341 Medical and Scientific Publishers E-Mail : [email protected] 3 Dear Faculty and Participants:

Welcome to Venice and the Birth Congress.

Previous Congresses have been held in Rome, Chicago, Fortaleza (Brazil) and Beijing. We have selected Palazzo del Cinema for the Birth Congress this year. It is located on the Lido di Venezia, which is the main headquarter for the Venice International Film Festival.

The Congress focuses on the challenges facing clinicians in Labor and Delivery Units worldwide. The emphasis of the Congress is clinical obstetrics and the faculty includes distinguished intellectual leaders from all over the world.

The last day of the Congress will be devoted to preterm birth and will coincide with World Prematurity Day, which is on November 17th.

Our Opening Ceremony will be on Thursday, November 15th at the conclusion of the scientific sessions.

The program will also be available in the Birth Congress IDT (interactive digital tool) along with many other features such as Q&A with the speakers. You will receive additional details upon check-in at the Congress.

An important development is the Birth Platform, which will include regular posts of recently published scientific material that is relevant to clinical practice. We encourage you to join the Birth Platform to stay informed on the latest developments. You can register for this at the Birth Platform Booth located at the congress venue.

Sincerely,

Gian Carlo di Renzo, MD, PhD Roberto Romero, MD, D.MeD.Sci. Congress President Congress President

4 November 14 - 17, 2018| Venice, Italy

HOW TO DOWNLOAD THE CONGRESS APP

1. CONNECT TO THE WI-FI

NETWORK NAME: CONVENTIONCENTER PASSWORD: BIRTH2018

2. ACCESS YOUR APP STORE

3. DOWNLOAD THE APP

MCA EVENTS Tecnoconference

4. SELECT THE EVENT BIRTH

5. CLICK ON “REGISTRATION” AND DIGIT YOUR EMAIL!

THE PASSWORD IS OF YOUR CHOICE

You can now interact with speakers using Q&A on MCA APP. Ask questions to the speakers directly via APP and engage the discussion at the end of the sessions.

5 GENERAL INFORMATION

CONGRESS VENUE

Palazzo del Cinema Lungomare Guglielmo Marconi - 30126 Lido VENICE, ITALY

WI-FI

Network Name: ConventionCenter Password: Birth2018

ORGANISING SECRETARIAT

Via Ambrogio Binda, 34 | 20143 Milano - Italy Ph. +39 02 34934404 | Fax +39 02 34934397 [email protected] www.mcascientificevents.eu

REGISTRATION DESK OPENING HOURS

Wednesday, November 14th From 08.00 am to 06.00 pm Thursday, November 15th From 07.00 am to 08.00 pm Friday, November 16th From 07.30 am to 07.00 pm Saturday, November 17th From 07.30 am to 08.00 pm

OFFICIAL LANGUAGE

English is the official language of the Congress.

CERTIFICATE OF ATTENDANCE

The Certificate of Attendance will be available to download on the official website www.birthcongress.eu at the end of the Congress.

6 November 14 - 17, 2018| Venice, Italy

INTERNATIONAL ACCREDITATION (UEMS)

UEMS – European Union of Medical Specialists: 32 credits recognized.

The congress “BIRTH - Clinical Challenges in Labor and Delivery, 14/11/2018 - 17/11/2018” has been accredited by the European Accreditation Council for Continuing Medical Educational (EACCME) for the entire congress. EACCME credits are recognized Europe-wide and in North America they can be exchanged for their national equivalent by contacting your national CME authority.

The scientific Programme was printed on November 9th. Any changes made after that date will be added on the official website www.birthcongress.eu and on the congress APP.

Share your experience by using the hashtag #BirthCongress on

/Birth.Congress /Birth.Congress

platform.mcascientificevents.eu/groups/birth

MCA Events is not responsible for the scientific content of the programme

7 CHAIRPERSONS

Prof. Gian Carlo Di Renzo Prof. Roberto Romero Chairman Department of Obstetrics and Chief of the Perinatology Research Branch, Gynecology, University of Perugia, Italy. Program and Division Director for Perinatal Research and Obstetrics in the Division of Intramural Research of NICHD/NIH, Detroit, United States.

INVITED SPEAKERS

Reuven Achiron, Israel Ioannis Gallos, UK Mohamed Momtaz, Egypt Kristina Adams-Waldorf, USA Maria Teresa Gervasi, Italy Louis Muglia, USA Abdallah Adra, Lebanon Renuka Gadde, USA Anwar Nassar, Lebanon Filomena Aloisio, Italy Tullio Ghi, Italy Isabella Neri, Italy Aris Antsaklis, Greece Alexis Gimovsky, USA James Newhouse, Italy Diogo Ayres De Campos, Portugal Nardhy Gomez-Lopez, USA Jan Nijhuis, The Netherlands Antonio Barbera, USA Maria M. Goya Canino, Spain Patrick O’Brien, UK Sergey Barinov, Russia Janesh Gupta, UK Jose M. Palacios-Jaraquemada, Argentina Jon Barrett, Canada Emily Hamilton, USA Mihaela Pavlicev, USA Federica Bellussi, Italy Sonia Hassan, USA Hala Phipps, Australia Giuseppe Benagiano, Switzerland Hagar Haviv, Australia Sophie Renwick, UK Pierluigi Benedetti Panici, Italy Hanns Helmer, Austria Giuseppe Rizzo, Italy Phillip R. Bennett, UK Wolfgang Henrich, Germany Mike Robson, Ireland Vincenzo Berghella, USA Corinne Hubinont, Belgium Karl Rosen, Sweden Despina Briana, Greece Bo Jacobsson, Sweden Loic Sentilhes, France Flavia Bustreo, Switzerland Eric Jauniaux, UK Roman Shmakov, Russia Bruno Carbonne, Monaco Karim Kalache, Qatar Joe Leigh Simpson, USA Aaron Caughey, USA Asma Khalil, UK Roger Smith, Australia Edwin Chandrahran, UK Arianne Kiener, Italy Giuseppe Sofi, Italy Silvia Chiarelli, Italy Steven Koenen, The Netherlands Francisco Songane, Mozambique Agustin Conde-Agudelo, Colombia Sabrina Kuah, Australia Michael Stark, Germany Bradley de Vries, Australia Krzysztof M. Kuczkowski, USA Stacey D. Stewart, USA Jan Deprest, Belgium Katariina Laine, Norway Jerome Strauss III, USA Gianpaolo Donzelli, Italy Christopher Lees, UK Alice Suprani, Italy Tim Draycott, UK Donatella Lippi, Italy Daniel Surbek, Switzerland Sarah Rae Easter, USA Enrico Lopriore, The Netherlands Marleen Temmerman, Kenya Tornbjorn M. Eggebo, Norway Frank Louwen, Germany Yves Ville, France Gunvor Ekman-Ordeberg, Sweden Ariadne Malamitsi-Puchner, Greece Gerard H.A. Visser, The Netherlands Offer Erez, Israel Antonio Malvasi, Italy Liliana Voto, Argentina Maria Fernanda Escobar, Colombia Valentina Marcon, Italy Gunter Wagner, USA Fabio Facchinetti, Italy Marialina Marcucci, Italy Eva Wiberg-Itzel, Sweden Dan Farine, Canada Bianca Masturzo, Italy Mariana Widmer, Switzerland Enrico Ferrazzi, Italy Anton Mikhailov, Russia Huixia Yang, China Eduardo Fonseca, Brazil Irina Mogilevkina, Ukraine Carlos Fuchtner, Bolivia Kelle Moley, USA

8 November 14 - 17, 2018| Venice, Italy

ROOMS IN USE

Wednesday, 14th November - PRE CONGRESS COURSES

1st FLOOR

FIRENZE ROOM: COURSE 1 - ULTRASOUND IN LABOUR AND DELIVERY NAPOLI ROOM: COURSE 3 - ACUTE EMERGENCIES (DIC, AF EMBOLISM, HEART FAILURE, ANESTHESIA ETC) BOLOGNA ROOM: COURSE 6 - SIMULATION: TWIN VAGINAL DELIVERY VERONA ROOM: COURSE 7 - A SIMULATION COURSE: ULTRASOUND IN THE MANAGEMENT OF OBSTETRICAL EMERGENCIES CAGLIARI ROOM: SLIDE CENTRE

GROUND FLOOR

VENEZIA ROOM: COURSE 4 - COMMON PROBLEMS IN LABOUR (in cooperation with FNOPO)

– 1 FLOOR MILANO ROOM: COURSE 2 - TECHNIQUES OF CESAREAN DELIVERY AND SURGICAL MANAGEMENT OF PPH ROMA ROOM: COURSE 5 - INTRAPARTUM FETAL MONITORING

15th - 17th November - CONGRESS

GROUND FLOOR

VENEZIA ROOM: ALL SESSIONS

1st FLOOR

BOLOGNA ROOM: FACULTY ROOM CAGLIARI ROOM: SLIDE CENTRE BECTON DICKINSON OFFICE: SIMULATION OF ODON DEVICE

9 WEDNESDAY, 14th NOVEMBER 2018 PRECONGRESS COURSES

09.00 - 17.30 COURSE 1 ULTRASOUND IN LABOUR AND DELIVERY Course Directors: Tornbjorn M. Eggebo, Norway; Karim Kalache, Qatar

09.00 - 09.10 Welcome and Introduction Karim Kalache, Qatar

09.10 - 10.20 FIRST STAGE OF LABOR Chairperson: Tullio Ghi, Italy

09.10 - 09.40 Measurements during the first stage of labor as predictor of the progress and outcome of labor Tornbjorn Eggebo, Norway

09.40 - 10.10 Repeated measurements and the sonopartogram Christopher Lees, UK

10.10 - 10.20 DISCUSSION

10.20 - 10.45 BREAK

10.45 - 12.30 FETAL MALPOSITION AND CEPHALIC MALPRESENTATIONS Chairperson: Tornbjorn Eggebo, Norway

10.45 - 11.15 The use of intrapartum ultrasound to diagnose malpositions and cephalic malpresentations Tullio Ghi, Italy

11.15 - 12.05 Fetal head asynclitism Antonio Malvasi, Italy

NOVEMBER 2018 th 12.05 - 12.20 Practical approach, tips, tricks and things to avoid Antonio Malvasi, Italy

12.20 - 12.30 DISCUSSION

WEDNESDAY, 14 WEDNESDAY,

10 November 14 - 17, 2018| Venice, Italy

12.30 - 13.30 LUNCH

13.30 - 15.15 SECOND STAGE OF LABOR Chairperson: Karim Kalache, Qatar

13.30 - 13.50 Sonographic parameters for diagnosing fetal head station Tullio Ghi, Italy

13.50 - 14.20 Transperineal ultrasound to predict complicated operative deliveries Karim Kalache, Qatar

14.20 - 14.40 Practical approach, tips, tricks and things to avoid Karim Kalache, Qatar

14.40 - 15.00 Routine use in prolonged second stage of labor: What does the research say? Christopher Lees, UK

15.00 - 15.15 DISCUSSION

15.15 - 15.40 BREAK

15.40 - 16.40 IMPACT AND OUTLOOK Chairperson: Christopher Lees, UK

15.40 - 16.00 Clinical guidelines Tullio Ghi, Italy

16.00 - 16.20 Intrapartum ultrasound in low resource settings Tornbjorn Eggebo, Norway

16.20 - 16.40 10 Key messages and take away points Tornbjorn Eggebo, Norway

16.40 - 17.10 Closing lecture: US in the delivery room: need or luxury? Reuven Achiron, Israel

17.10 - 17.30 PANEL DISCUSSION NOVEMBER 2018 • Who should examine? th • Teaching examiners? • Future perspective WEDNESDAY, 14 WEDNESDAY,

11 09.00 - 16.30 COURSE 2 TECHNIQUES OF CESAREAN DELIVERY AND SURGICAL MANAGEMENT OF PPH Course Directors: Vincenzo Berghella, USA; Jose Palacios-Jaraquemada, Argentina

An update of classical obstetric procedures is proposed in a compact format. Certain aspects of cesarean section are up to date according to recent data and investigation, which also include hazardous scenarios analyzed from skilled specialists. The postpartum hemorrhage is reviewed from the classic procedures until new approaches for treatment. Use of simple examples will be useful to explain why is necessary to apply some change of paradigms. We will do a particular effort to provide a simple, clear, and useful information for the clinical practice, which include information from prospective randomized trials. Use of learning objectives allows us to put a focus in controversial points.

09.00 - 09.15 Introduction

09.15 - 09.30 Interventions before cesarean delivery Vincenzo Berghella, USA

• To review evidence for prophylactic antibiotics before cesarean • To review evidence for antithrombotic prophylaxis before cesarean delivery • To assess evidence for room temperature at cesarean delivery • To review evidence for type of drapes at cesarean delivery

09.30 - 09.50 From skin to uterus Jose Palacios-Jaraquemada, Argentina

• To assess recommendation for hand washing to infection reduction • To manage the timing and routes to the use prophylactic antibiotics • To determine the effectivity of different skin antisepsis to prevent infections • To evaluate the requirements to skin to skin contact at cesarean

09.50 - 10.10 Where should the uterine incision be performed; From uterine incision to closure Michael Stark, Germany

• To prove the importance of evidence-based approach compared to tradition • To define the most optimal abdominal opening and closure NOVEMBER 2018 th • To explain the reasons for adhesions and how to avoid them • To show how rational suturing of the uterus can prevent ruptures in the next pregnancies. WEDNESDAY, 14 WEDNESDAY,

12 November 14 - 17, 2018| Venice, Italy

10.10 - 10.30 DISCUSSION

10.30 - 11.00 BREAK

11.00 - 11.20 Closing the abdomen Aris Antsaklis, Greece

• To review the different techniques of closing the uterus and abdomen. • To assess the difference between closure vs non-closure of the peritoneum. • To review evidence for the use of different type of drains. • To access the different techniques of facial closure.

11.20 - 11.40 Immediate postoperative care Vincenzo Berghella, USA

• To review evidence for timing of food intake after cesarean delivery • To review evidence for chewing gum after cesarean delivery • To assess evidence for timing of wound dressing removal after cesarean delivery • To review evidence for timing of ambulation and discharge after cesarean delivery

11.40 - 12.00 Cesarean in the obese patient Mohamed Momtaz, Egypt

• To review the prevalence and impact of obesity on pregnancy outcome and mode of delivery. • To assess evidence for management of obese women during pregnancy and labor. • To review the surgical, anesthetic, and logistical challenges in Cesarean section in obese women. • To assess evidence of pre-operative preparation, surgical techniques, and post-operative care for Cesarean section in obese women.

12.00 - 12.30 DISCUSSION

12.30 - 13.30 LUNCH

13.30 - 13.50 Cesarean in a patient in the 2nd stage of labor: difficulties and prognosis for future pregnancies Alexis Gimovsky, USA NOVEMBER 2018 • To explain predictors for cesarean delivery in the 2nd stage of labor th • To recognize the difficulties of performing cesarean delivery in the 2nd stage of labor • To analyze delivery techniques in 2nd stage cesarean delivery • To recognize the risks in future pregnancy related to prior 2nd stage cesarean delivery

WEDNESDAY, 14 WEDNESDAY,

13 13.50 - 14.10 Cesarean scar niche. Possibilities of prevention and treatment Roman Shmakov, Russia

• To assess indications for laparoscopic and hysteroscopic correction of the niche. • To review complications and risks for pregnancy management in women with niches • To review possibility of vaginal delivery after scar plastics

14.10 - 14.40 Unexpected bleeding at cesarean: concept of primary and secondary hemostasis. When to transfuse and how Jose Palacios-Jaraquemada, Argentina

• To understand why on PPH always needs to solve two problems • To introduce a concept of primary hemostasis • To manage simple techniques to stop bleeding without hysterectomy • To recognize main causes of hemostasis failure

14.40 - 15.00 DISCUSSION AND BREAK

15.00 - 15.20 Intrauterine balloon tamponade in PPH during cesarean: an update Sergey Barinov, Russia

• To know indication and managing of the Zhukovsky balloon catheter • To recognize techniques for improving efficacy of uterine-vaginal balloon tamponade • To recognize the advantage of long action balloon compression (≥10 h) • To manage a simultaneous use of double balloon, and additional hemostatic sutures

15.20 - 15.50 Abnormal placental implantation disorders: management Pierluigi Benedetti Panici, Italy

• To review evidence for the diagnostic algorithm for placental implantation disorders • To review evidence for timing of scheduled delivery and intrapartum care • To review evidence for balloon catheterization and arterial embolization in pelvic vessels and abdominal aorta • To review evidence for active vs conservative management NOVEMBER 2018 th WEDNESDAY, 14 WEDNESDAY,

14 November 14 - 17, 2018| Venice, Italy

15.50 -16.10 Management of abnormal bleeding in twin pregnancies Anton Mikhailov, Russia

• To review the prevalence and impact of multiple pregnancy on PPH. • To review the methods of prophylactic and management of PPH after multiple vaginal delivery • To introduce a team work strategy to stop PPH during multiple Cesarean delivery • To introduce external elastic uterine compression as effective step of organ saving strategy in PPH

16.10 - 16.30 DISCUSSION / CONCLUSIONS NOVEMBER 2018 th WEDNESDAY, 14 WEDNESDAY,

15 09.00 - 17.30 COURSE 3 ACUTE EMERGENCIES (DIC, AF EMBOLISM, HEART FAILURE, ANESTHESIA ETC) Course Directors: Krzysztof M. Kuczkowski, USA; Wolfgang Henrich, Germany; Offer Erez, Israel

Acute life threatening obstetric and non-obstetric related emergencies in pregnancy are rare. Common obstetric complications such as postpartum hemorrhage due to atony, deeply invasive placenta implantation disorders, placental abruption, obstetric trauma, severe preeclampsia, eclampsia and peripartum infections can indeed occasionally be fatal. However, even experienced obstetricians have to be aware of the other major acute diseases that are relatively rare in obstetrics such as cardiac arrest, amniotic fluid embolism, idiopathic pulmonary hypertension, aortic dissection, peripartum cardiomyopathy, severe acute respiratory diseases and anesthetic complications. Most of these relatively rare life threatening complications may present with unspecific or atypical symptoms and will require interdisciplinary investigations including for example a detailed physical examination, echocardiography, abdominal ultrasound and specific blood tests. The interdisciplinary teamwork of anesthetists, surgeons, cardiologists, internal medicine specialists, hematologists and obstetrician is essential for the early diagnosis and appropriate therapy in these situations. The course of Acute Emergencies is brought by experienced and specialized obstetricians from all over the world will hold lectures during the course, and present not only the typical obstetrical emergencies but also the most relevant thoracic, abdominal and systemic illnesses with case presentations highlighting the pathophysiology and current management strategies of such life threatening complications.

09.00 - 09.05 Opening remarks: welcome & introduction

09.05 - 09.35 Aortic dissection in pregnancy: interdisciplinary management Wolfgang Henrich, Germany

09.35 - 10.05 Acute respiratory distress syndrome in pregnancy Krzysztof M. Kuczkowski, USA

10.05 - 10.35 Amniotic fluid embolism: current concepts and management Wolfgang Henrich, Germany NOVEMBER 2018 th 10.35 - 11.00 BREAK WEDNESDAY, 14 WEDNESDAY,

16 November 14 - 17, 2018| Venice, Italy

11.00 - 11.30 Anesthesia in the critically ill mother Krzysztof M. Kuczkowski, USA

11.30 - 12.00 Thromboembolic diseases during pregnancy diagnosis, management and prevention Offer Erez, Israel

12.00 - 12.30 New concepts in sepsis and septic shock Maria Fernanda Escobar, Colombia

12.30 - 13.30 LUNCH

13.30 - 14.00 Disseminated intravascular coagulation: pathophysiology, diagnosis and management Offer Erez, Israel

14.00 - 14.30 Placental Abruption: risk factors for the mother and neonate Wolfgang Henrich, Germany

14.30 - 15.00 Serious hepatic complications: acute fatty liver of pregnancy, liver rupture, and liver failure during pregnancy Offer Erez, Israel

15.00 - 15.30 BREAK

15.30 - 16.00 Trauma during pregnancy Maria Fernanda Escobar, Colombia

16.00 - 16.30 An acute hypertensive emergency Wolfgang Henrich, Germany

16.30 - 17.00 PANEL DISCUSSION: Critical care in obstetrics: the role for an intensive obstetrical care unit NOVEMBER 2018 th WEDNESDAY, 14 WEDNESDAY,

17 09.00 - 17.00 COURSE 4 COMMON PROBLEMS IN LABOUR (in cooperation with FNOPO) Where and how to manage low risk labor in the era new obstetrics risks: obesity, art, older maternal age, and socially deprived immigrants Course Director: Enrico Ferrazzi, Italy

The aim of the course is to present key issues and local experiences on the safe place of birth for low risk pregnant women.

09.00 - 12.30 SESSION 1

09.00 - 09.10 Opening remarks Enrico Ferrazzi, Italy

09.10 - 09.40 Which screenings to assess a low risk pregnant woman? Sophie Renwick, Tim Draycott, UK

09.40 - 10.10 Which screenings to assess a low risk pregnant woman. Does fetal growth matters? Abdallah Adra, Lebanon

10.10 - 10.40 Maternal obesity before pregnancy, and morbid obesity at term, demographic indices or a disease? Dan Farine, Canada

10.40 - 11.10 When and how to deliver in previous and gestational diabetes pregnancies Liliana Voto, Argentina

11.10 - 11.20 BREAK

11.20 - 11.50 Term, Late Term does it make a difference on perinatal outcome? Gerard Visser, The Netherlands

11.50 - 12.20 Planned home births: the need for additional contraindications? Jan Nijhuis, The Netherlands NOVEMBER 2018 th

12.20 - 12.30 OPEN PANEL DISCUSSION

WEDNESDAY, 14 WEDNESDAY, 12.30 - 14.00 LUNCH

18 November 14 - 17, 2018| Venice, Italy

14.00 - 17.00 SESSION 2

14.00 - 14.30 Walking epidural, is it changing the set for low risk women in labor? Giuseppe Sofi, Italy

14.30 - 15.00 Midwives-only-led labor in low-risk women in a Referral Obstetric Unit? The Milan Experience Valentina Marcon, Silvia Colombo, Italy

15.00 - 15.30 Alongside Midwife Units–which setting? The Florence Experience Laura Iannuzzi, Italy

15.30 - 16.00 Acupressure- acupuncture for pain in labour Isabella Neri, Italy

16.00 - 16.30 Prevention and management of OASIS (obstetric anal sphincter injuries) Abdallah Adra, Lebanon

16.30 - 17.00 Open panel discussion and closing remarks

NOVEMBER 2018 th WEDNESDAY, 14 WEDNESDAY,

19 09.00 - 17.30 COURSE 5 INTRAPARTUM FETAL MONITORING Course Directors: Diogo Ayres De Campos, Portugal; Gerard H. Visser, The Netherlands

Current expectations on a favourable neonatal outcome leave little room for error in intrapartum fetal monitoring, but at the same time it is necessary to maintain low obstetric intervention rates. This course focuses on the pathophisiologic changes behind fetal heart rate patterns, their interpretation and management. It is based on the 2015 FIGO guidelines for intrapartum fetal monitoring.

13.30 - 13.35 Introduction Diogo Ayres De Campos, Portugal

13.35 - 14.10 Physiology of fetal oxygenation Gerard H. Visser, the Netherlands

14.10 - 14.45 Interpretation of the cardiotocogram Diogo Ayres de Campos, Portugal

14.45 - 15.10 Adjunctive technologies Edwin Chandraharan, UK

15.10 - 15.30 Monitoring uterine contractions Steven Koenen, The Netherlands

15.30 - 17.30 CASE DISCUSSION NOVEMBER 2018 th WEDNESDAY, 14 WEDNESDAY,

20 November 14 - 17, 2018| Venice, Italy

13.30 - 17.30 COURSE 6 SIMULATION: TWIN VAGINAL DELIVERY Course Directors: Jon Barrett, Canada; Sarah Rae Easter, USA

Discussants: Frank Louwen, Germany, Ian Nijhuis, The Netherlands

OBJECTIVES

At the end of the simulation the learner will be able to:

• Outline the safety, benefits, and relative contraindications to twin vaginal birth. • Counsel and consent a patient for an attempted twin vaginal birth. • Demonstrate the requisite skills for a breech extraction of the second twin. • Describe maneuvers and strategy for the challenging breech extraction. • Exhibit proficiency in managing a twin vaginal birth with emphasis on delivery of the second twin.

OUTLINE

Introduction to Session and Survey Completion Review of Evidence-Based Guidelines and Approach to Counseling Standardized Patient Counseling

• Session 1: Vertex/Vertex Twins • Session 2: Vertex/Nonvertex Twins

Hands on Practice with Breech Extraction Skills Stations Rotating

• Station 1: Grasping the Feet • Station 2: Delivery of Body, Arms, and Head • Station 3: Break and Volunteer Selection

Description and Completion of Twin Delivery Simulation

• Scenario 1 and Debriefing: Intrapartum Presentation Change NOVEMBER 2018

• Scenario 2 and Debriefing: Fetal Bradycardia th

CONCLUSION AND EVALUATIONS WEDNESDAY, 14 WEDNESDAY,

21 09.00 - 16.30 COURSE 7 A SIMULATION COURSE: ULTRASOUND IN THE MANAGEMENT OF OBSTETRICAL EMERGENCIES Organized by EGEO group (Ecografia Gestione Emergenze Ostetriche) and SIEOG

09.00 - 11.00 THEORETICAL PART Chairpersons: Giuseppe Rizzo, Italy, Antonio Barbera, USA

Faculty: Giuseppe Rizzo, Tullio Ghi, Bianca Masturzo, Alice Suprani, Arianne Kiener, Federica Bellussi, Filomena Aloisio

The role of ultrasound in obstetrical simulation Ultrasound before performing an operative vaginal delivery Ultrasound in predicting and managing suspected shoulder dystocia Ultrasound in the management of obstetrical hemorrhage

Ultrasound in the diagnosis of anal sphincter injuries

11.00 - 11.30 BREAK

11.30 - 12.30 Simulation skill on mannequins

12.30 - 13.30 LUNCH BREAK

13.30 - 16.30 Simulation skills on mannequins

• Operative vaginal delivery with either vacuum or forceps • Shoulder dystocia: a systematic approach • Post partum haemorrhage • Diagnosis and repair of anal sphincter injuries NOVEMBER 2018 th WEDNESDAY, 14 WEDNESDAY,

22 November 14 - 17, 2018| Venice, Italy

THURSDAY, 15th NOVEMBER 2018 PHYSIOLOGY OF LABOR, MONITORING MOTHER AND FETUS, AND COMPLEX ISSUES ABOUT ABNORMAL LABOR PROGRESS AND INDUCTION OF LABOR AT TERM

08.00 - 10.30 SESSION 1 DEFINITION, DIAGNOSIS AND MONITORING OF NORMAL TERM LABOR - PART 1 Chairs: Gian Carlo Di Renzo, Italy; Roberto Romero, USA

08.00 - 08.30 Classical concepts of labor progress and nomenclature of labor disorders Roberto Romero, USA

08.30 - 09.00 The diagnosis of labor at term: life must be lived forward but can only be interpreted backward Roger Smith, Australia

09.00 - 09.25 Prolonged Latent Phase of Labor: diagnosis and management Aaron Caughey, USA

09.25 - 09.50 Friedman and Zhang: the labour curves’ debate Emily Hamilton, Canada

09.50 - 10.00 DISCUSSION

10.00 - 10.30 SPECIAL LECTURE: The obstetrical dilemma: what is it and what does it mean for biology, evolution, and clinical obstetrics? Mihaela Pavlicev, USA

10.30 - 10.50 BREAK, POSTER VIEW, EXHIBITS NOVEMBER 2018 th THURSDAY, 15 THURSDAY,

23 10.50 - 12.45 SESSION 2 THE SECOND STAGE OF LABOR Chairs: Aaron Caughey, USA; Tim Draycott, UK

10.50 - 11.05 Assessment of progress in the second stage of labor: digital, ultrasound, magnetic monitoring and others Dan Farine, Canada

11.05 - 11.25 Second stage of labor: protracted descent and arrest – diagnosis and management Aaron Caughey, USA

11.25 - 11.45 What is the real effect of epidural analgesia in the second stage of labor? Krzysztof M. Kuczkowski, USA

11.45 - 12.05 When should women push and for how long in the second stage of labor Jon Barrett, Canada

12.05 - 12.25 Is there a role for episiotomy in modern obstetrics? Anwar Nassar, Lebanon

12.25 - 12.45 DISCUSSION

12.45 - 13.30 BREAK, POSTER VIEW, EXHIBITS

13.30 - 15.30 SESSION 3 MONITORING OF TERM LABOR Chairs: Gerard H. Visser, the Netherlands; Daniel Surbek, Switzerland

13.30 - 13.50 Fetal heart rate assessment during labor Diogo Ayres De Campos, Portugal

13.50 - 14.05 Simplifying EFM Interpretation Emily Hamilton, Canada NOVEMBER 2018 th 14.05 - 14.25 How to monitor uterine contractions? Steven Koenen, The Netherlands THURSDAY, 15 THURSDAY,

24 November 14 - 17, 2018| Venice, Italy

14.25 - 14.45 The controversy about ST segment analysis: randomized clinical trials and meta-analyses, and the way forward Karl Rosen, Sweden

14.45 - 15.10 Umbilical cord pH gases and lactate: normal values, diagnosis of metabolic and respiratory acidemia, and clinical implications Edwin Chandraharan, UK

15.10 - 15.20 Head station in labour monitoring Irina Mogilevkina, Ukraine

15.20 - 15.30 DISCUSSION

15.30 - 15.50 BREAK, POSTER VIEW, EXHIBITS

15.50 - 16.10 FIGO SPECIAL LECTURE: 50 years of Rh disease prophylaxis: looking back and going forward Gian Carlo Di Renzo, Italy Introduced by: Gerard H. Visser, The Netherlands

16.10 - 18.20 SESSION 4 INDUCTION AND ACCELERATION OF LABOR Chairs: Mike Robson, Ireland; Ian Nijhuis, The Netherlands

16.10 - 16.30 What is new about oxytocin: physiology, method of administration and adverse events Daniel Surbek, Switzerland

16.30 - 16.50 Prostaglandins for the induction of labor Fabio Facchinetti, Italy

16.50 - 17.10 Mechanical methods for induction of labor Janesh Gupta, UK

17.10 - 17.30 Definition of a failed induction of labor Dan Farine, Canada NOVEMBER 2018 th 17.30 - 17.50 Should every woman be induced at 39 weeks? Aaron Caughey, USA THURSDAY, 15 THURSDAY,

25 17.50 - 18.10 Incidence, risks, benefits and audit of acceleration of labour with oxytocin Mike Robson, Ireland

18.10 - 18.20 DISCUSSION

18.20 - 18.50 KEYNOTE LECTURE: Current understanding of the mechanisms responsible for the onset of labor Roger Smith, Australia Introduced by Roberto Romero, USA

19.00 - 20.00 OPENING CEREMONY

Introduction Chairs: Gian Carlo Di Renzo, Italy; Roberto Romero, USA

OPENING LECTURE: Labor and delivery through the centuries: the holistic view of a stakeholder Donatella Lippi, James Newhouse, Italy

20.00 - 21.30 WELCOME RECEPTION NOVEMBER 2018 th THURSDAY, 15 THURSDAY,

26 November 14 - 17, 2018| Venice, Italy

FRIDAY, 16th NOVEMBER 2018 CHALLENGES IN EVERYDAY PRACTICE IN LABOR AND DELIVERY

08.00 - 10.20 SESSION 5 OPERATIVE DELIVERY Chairs: Vincenzo Berghella, USA; Tim Draycott, UK

08.00 - 08.20 Why and when to intervene in the 2nd stage of labor Aaron Caughey, USA

08.20 - 08.40 Teaching providers to self-regulate delivery force during shoulder dystocia Edith Gurewitsch Allen, USA

08.40 – 09.00 Vacuum and forceps: pros and cons Bruno Carbonne, Monaco

09.00 - 09.15 Amniotic fluid lactate to monitor the uterine metabolic status and predict cesarean section Eva Wiberg Itzel, Sweden

09.15 - 09.25 POP-OUT Trial Persistent Occiput Posterior position: OUT comes following manual rotation. A prospective double blinded RCT exploring the impact of prophylactic manual rotation on operative delivery rates Hala Phipps, Bradley de Vries, Australia

09.25 - 09.45 Cesarean delivery in the 2nd stage: difficulties and tips Vincenzo Berghella, USA

09.45 - 10.05 Breech deliveries: how to do it? Frank Louwen, Germany

10.05 - 10.15 Short Video Communication: Managing uterine inversion NOVEMBER 2018 Sabrina Kuah, Hagar Haviv, Australia th

10.15 - 10.20 DISCUSSION FRIDAY, 16 FRIDAY,

27 10.20 - 10.50 FIGO SPECIAL LECTURE: Can the rate of cesarean delivery be reduced: why and how? Gerard H. Visser, The Netherlands Introduced by Carlos Fuchtner, Bolivia

10.50 - 12.10 SESSION 6 THE PELVIC FLOOR Chairs: Corinne Hubinont, Belgium; Michael Stark, Germany

10.50 - 11.10 Pelvic floor childbirth injury: mechanisms, consequences, and long-term prognosis Katariina Laine, Norway

11.10 - 11.30 The pelvic floor after spontaneous and operative delivery: insights deriving from imaging techniques Jan Deprest, Belgium

11.30 - 11.50 How to repair 3rd or 4th degree lacerations Michael Stark, Germany

11.50 - 12.10 DISCUSSION

12.10 - 12.50 LUNCH TIME, POSTER VIEW, EXHIBITS

12.50 - 14.10 SPECIAL SYMPOSIUM POST PARTUM HEMORRHAGE PREVENTION: INCREASING THE QUALITY OF EVIDENCE Chairs: Loïc Sentilhes, France; Gian Carlo Di Renzo, Italy

12.50 - 12.55 Introduction Gian Carlo Di Renzo, Italy

12.55 - 13.15 CHAMPION: The largest prevention trial in postpartum hemorrhage Mariana Widmer, WHO Switzerland

13.15 - 13.35 The impact of CHAMPION study on a Cochrane network meta-analysis

NOVEMBER 2018 Ioannis Gallos, UK th FRIDAY, 16 FRIDAY,

28 November 14 - 17, 2018| Venice, Italy

13.35 - 13.55 IMax: Comparative clinical trial in the UK setting Tim Draycott, UK

13.55 - 14.05 DISCUSSION

14.05 - 14.10 Closing remarks Loïc Sentilhes, France

14.10 - 16.15 SESSION 7 CESAREAN DELIVERY: THE MOST COMMON OPERATION IN THE WORLD Chairs: Dan Farine, Canada; Gerard H. Visser, The Netherlands

14.10 - 14.35 How to perform a cesarean delivery: a critical appraisal of surgical technique Michael Stark, Germany

14.35 - 15.00 Perioperative care of patients with cesarean delivery (skin, antibiotics, catheterization, heparin, oxytocin vs prostaglandins) Vincenzo Berghella, USA

15.00 - 15.20 Cesarean scar defects: implications and repair alternatives Jose Palacios-Jaraquemada, Argentina

15.20 - 15.40 Anesthetic challenges for cesarean delivery: problems and complications Krzysztof M. Kuczkowski, USA

15.40 - 16.00 Classification of Cesarean delivery and monitoring of utilization of the procedure around the world Mike Robson, Ireland

16.00 - 16.15 DISCUSSION

16.15 - 16.40 BREAK, POSTER VIEW, EXHIBITS NOVEMBER 2018 th FRIDAY, 16 FRIDAY,

29 16.40 - 18.40 SESSION 8 POSTPARTUM HEMORRHAGE, PLACENTAL IMPLANTATION DISORDERS AND SPECIAL CHALLENGES Chairs: Eric Jauniaux, UK; Carlos Fuchtner, Bolivia

16.40 - 17.00 The prevention of postpartum hemorrhage - an evidence-based approach Corinne Hubinont, Belgium

17.00 - 17.20 Anomalies of placentations and risk of PPH Eric Jauniaux, UK

17.20 - 17.40 Management of postpartum hemorrhage in cases of invasive implantation Huixia Yang, China

17.40 - 18.00 The special challenge of Cesarean delivery in obese patients or those with leiomyomas Dan Farine, Canada

18.00 - 18.10 DISCUSSION

18.10 - 18.40 KEYNOTE ADDRESS: The Odon Device: a revolution in the vaginal assisted delivery Tim Draycott, UK Introduced by Gian Carlo Di Renzo, Italy

18.40 ADJOURN NOVEMBER 2018 th FRIDAY, 16 FRIDAY,

30 November 14 - 17, 2018| Venice, Italy

SATURDAY, 17th NOVEMBER 2018 SPECIAL SESSIONS CELEBRATING THE “INTERNATIONAL PREMATURITY DAY”

08.00 - 10.00 SESSION 9 MECHANISMS OF DISEASE FOR THE PRETERM LABOR SYNDROME - Part 1 Chairs: Roberto Romero, USA; Jerome Strauss III, USA

08.00 - 08.25 The preterm labor syndrome and the role of intra-amniotic infection Roberto Romero, USA

08.25 - 08.50 The vaginal microbiota as a predisposing factor to preterm delivery: controversy, new findings, and the role of prebiotics, probiotics and synbiotics Phillip R. Bennett, UK

08.50 - 09.10 Uterine overdistension (multiple gestations, polyhydramnios, and Mullerian Duct abnormalities) and preterm labor Dan Farine, Canada

09.10 - 09.30 Maternal anti-fetal rejection Nardhy Gomez-Lopez, USA

09.30 - 09.40 DISCUSSION

09.40 - 10.00 BREAK, POSTER VIEW, EXHIBITS NOVEMBER 2018 th SATURDAY, 17 SATURDAY,

31 10.00 - 11.30 SESSION 10 MECHANISM OF DISEASE FOR THE PRETERM LABOR SYNDROME - Part 2 Chairs: Hanns Helmer, Austria; Joe Leigh Simpson, USA

10.00 - 10.20 Vascular disorders and spontaneous and indicated preterm birth Asma Khalil, UK

10.20 - 10.40 New developments in the diagnosis and management of patients with preterm PROM (induction of labor, new antibiotic regimens, magnesium sulfate) Maria Teresa Gervasi, Italy

10.40 - 11.00 Gene-Environment interactions and Preterm Birth: the vaginal microbiome and fetal genome Jerome Strauss III, USA

11.00 - 11.20 Genetic predisposition to preterm birth Louis Muglia, USA

11.20 - 11.30 DISCUSSION

11.30 - 13.00 SPECIAL SESSION

CHILDREN BORN TOO SOON IN THE WORLD: HOW MANY, WHERE AND WHY? WHAT DO THE POLICY MAKERS NEED TO KNOW AND DO Chairs: Flavia Bustreo (FIGO); Stacey D. Stewart (March of Dimes) Participants: Giuseppe Benagiano, FIGO, Switzerland Flavia Bustreo, FIGO, Switzerland Gianpaolo Donzelli, Meyer Foundation, Italy Carlos Fuchtner, FIGO, Bolivia Renuka Gadde, USA Huixia Yang, Peking University First Hospital, China Marialina Marcucci, Kennedy Foundation, Italy Kelle Moley, March of Dimes, USA Francisco Songane, PMNCH, Mozambique Stacey D. Stewart, March of Dimes, USA NOVEMBER 2018 th Marleen Temmerman, Centre of Excellence in Women and Child Health, Kenya

13.00 - 13.30 LUNCH BREAK SATURDAY, 17 SATURDAY,

32 November 14 - 17, 2018| Venice, Italy

13.30 - 15.00 SESSION 11 PREDICTION OF PRETERM LABOR AND BIRTH Chairs: Yves Ville, France; Eduardo Fonseca, Brazil

13.30 - 13.50 Historical and clinical risk factors (history of preterm birth, body mass index, lifestyle, inter pregnancy interval) Bo Jacobsson, Sweden

13.50 - 14.15 Insights into the mechanisms responsible for cervical remodeling Gunter Wagner, USA

14.15 - 14.35 The uterine cervix and preterm birth risk assessment: new and emerging technologies Sonia Hassan, USA

14.35 – 14.50 Biochemical markers in vaginal fluid and maternal blood (PaMG1, Fibronectin, phosphorylated IGFBP-1 and proteomic markers) Gian Carlo Di Renzo, Italy

14.50 - 15.00 DISCUSSION

15.00 - 16.45 SESSION 12 PREVENTION Chairs: Gerard H. Visser, The Netherlands; Jon Barrett, Canada

15.00 - 15.20 Progesterone for the prevention of preterm birth: 17OHP-C and vaginal progesterone in patients with a prior history Eduardo Fonseca, Brazil

15.20 - 15.40 Vaginal progesterone for patients with a sonographic short cervix: singletons and twins Roberto Romero, USA

15.40 - 16.00 The role of cerclage in the prevention of preterm birth Vincenzo Berghella, USA NOVEMBER 2018 th 16.00 - 16.20 The role of cervical pessary in singletons and twins María M. Goya Canino, Spain SATURDAY, 17 SATURDAY,

33 16.20 - 16.40 How to deliver a malformed preterm fetus Yves Ville, France

16.40 - 16.45 DISCUSSION

16.45 - 17.00 BREAK, POSTER VIEW, EXHIBITS

17.00 - 18.20 SESSION 13

MANAGEMENT OF ACUTE PRETERM LABOR Chairs: Asma Khalil, UK; Phillip R. Bennett, UK

17.00 - 17.20 Tocolysis - is it worth it? Hanns Helmer, Austria

17.20 - 17.40 Steroids: beneficial or poisons? Gerard H. Visser, The Netherlands

17.40 - 18.00 Magnesium sulfate for neuroprotection: a critical appraisal of the evidence Agustin Conde-Agudelo, Colombia

18.00 - 18.20 Antibiotic administration to treat intra-amniotic inflammation in patients with preterm labor and intact membranes, preterm PROM and acute cervical insufficiency Roberto Romero, USA NOVEMBER 2018 th SATURDAY, 17 SATURDAY,

34 November 14 - 17, 2018| Venice, Italy

18.20 - 19.30 SESSION 14

THE OUTCOME Chairs: Ariadne Malamitsi-Puchner, Greece; Patrick O’Brien, UK

18.20 - 18.40 Delayed clamping of the umbilical cord: life saving in preterm neonates - evidence from RCTs and meta-analyses Enrico Lopriore, The Netherlands

18.40 - 19.00 Managing pregnancies at the limits of viability Patrick O’Brien, UK

19.00 - 19.20 The “golden hour” - importance of resuscitation in the early preterm neonate Despina Briana, Greece; Ariadne Malamitsi Puchner, Greece

19.20 - 19.30 DISCUSSION

19.30 - 20.00 CLOSING LECTURE: Reflections on World Prematurity Day (Why to have it) GianPaolo Donzelli, Meyer Foundation, Italy Introduced by Stacey D. Stewart, USA

20.00 - 20.10 CONCLUDING REMARKS Roberto Romero and Gian Carlo Di Renzo

20.10 END OF THE CONGRESS NOVEMBER 2018 th SATURDAY, 17 SATURDAY,

35 SPONSORS & EXHIBITORS

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36 November 14 - 17, 2018| Venice, Italy

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37 ACCURATE SRL

Address: via Volturno 61, 43125 Parma (PR) Web Site: www.accuratesolutions.it/en/ Email: [email protected] Phone Number: +39 054720630

Accurate S.r.l. encompasses advanced skills in software engineering applied to educational model and biomedical engineering, as well as a deep international experience of research and development of truly effective, hi-tech, educational models. Accurate innovative simulators are focused on the ultrasound, partient ventilation, obstetric and gynecology and human reproduction field.

ASTRAIA SOFTWARE GMBH

Address: Occamstr. 20, 80802 Munich, Germany Web Site: www.astraia.com Email: [email protected] Phone Number: +49 89 127 1147-0

Astraia (member of NEXUS-AG group) provides software solutions in Obstetrics and Gynaecology for structured documentation and reporting, quality assurance and scientific studies. Astraia was founded in 2000 and is based in Munich. A dedicated team of about 30 employees serves more than 1,500 customers in over 75 countries. In many countries, astraia is also represented by local sales partners. astraia cooperates closely with leading experts around the world, such as with the FMF, with whom astraia has a longstanding and successful cooperation. This collaboration is complemented by in-house expertise and the ability to adapt with flexibility to the market.

BESINS HEALTHCARE

Address: Besins Healthcare Monaco S.A.M Gildo Pastor Center, 7 rue du Gabian,98000, MONACO. Web Site: www.besins-healthcare.com Email: [email protected] Phone Number: +44 1344 586 800

Besins Healthcare is a 130-year-old global pharmaceutical company specializing in innovative hormonal solutions that safely restore, restart and regulate fundamental female and male body processes so the body can perform optimally. A fourth-generation, privately owned company, originating in Europe, now headquartered in Monaco. Besins Healthcare has continuously discovered ground-breaking technologies to improve patient well-being. It is a world leader in novel therapies for gynaecology and andrology. Besins Healthcare products are trusted and prescribed by healthcare professionals in more than 90 countries throughout the world.

CLINICAL INNOVATIONS

Address: 6-9 The Square, Stockley Park, Heathrow, UB11 1FW, United Kingdom Web Site: www.clinicalinnovations.com Email: [email protected] Phone Number: + 44 (0) 333 370 4408

Celebrating 25 years in business, Clinical Innovations manufactures medical products exclusively focused on labour, delivery and neonatal healthcare. Visit our stand to learn more about the market leading Kiwi® Vacuum-Assisted Delivery System and our latest innovations including traxi® Panniculus Retractor, ROM Plus® Fetal Membranes Rupture Test, ebb® Complete Tamponade System, ClearView Total® Uterine Manipulation System and babyLance™ safety heelstick.

38 November 14 - 17, 2018| Venice, Italy

FERRING PHARMACEUTICALS

Address: Ferring International Center S.A. Ch. De La Vergognausaz 50 1162 Saint-Prex, Switzerland Web Site: www.ferring.com Phone Number: +41 58 301 00 00

Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group committed to helping people around the world build families and live better lives. Headquartered in Saint-Prex, Switzerland, Ferring is a leader in reproductive medicine and women’s health, and in specialty areas within gastroenterology and urology. Ferring has been developing treatments for mothers and babies for over 50 years and has a portfolio covering treatments from conception to birth. Founded in 1950, privately-owned Ferring now employs approximately 6,500 people worldwide, has its own operating subsidiaries in nearly 60 countries and markets its products in 110 countries.

NEOVENTA MEDICAL AB

Address: Norra Ågatan 32, SE-431 35 Mölndal, Sweden Web Site: www.neoventa.com Email: [email protected] Phone Number: +46 31 758 32 00

Neoventa Medical AB is the provider of innovative fetal monitoring solutions that improve obstetric care. Our core competence lies in using the evidence-based ST Analysis of the fetal ECG as an adjunct to CTG during labour. When using the STAN Method you get a continuous and central message from the fetal heart. Numerous studies have shown that the STAN Method provides important information on intrapartum hypoxia, reduces metabolic acidosis and operative vaginal deliveries, at the same time being a cost-effective method both in a short- and long-term perspective.

OBSTECARE

Address: Karolinska Institutet Science Park, Fogdevreten 2, SE 171 65 SOLNA, Sweden Web Site: www.obstecare.com Email: [email protected] Phone Number: +46 8 751 56 27

ObsteCare offers solutions for improved care during child birth, to the benefit of both the mother, baby and maternity wards. Labor dystocia is a major problem during child birth, throughout the world. Approximately 40% of all first-time mothers suffer from dystocia and prolonged labor.

QIAGEN

Web Site: www.qiagen.com is the leading global provider of Sample to Insight solutions to transform biological materials into valuable molecular insights. QIAGEN’s commitment to prenatal care is evident through a comprehensive portfolio of tests which includes the AmniSure ROM Test and the PartoSure Test.

39 THE COMPLETE OBSTETRIC SOLUTION

™

safety heelstick

clinicalinnovations.com 6-9 The Square | Stockley Park Heathrow UB11 1FW | United Kingdom Phone +44 333 370 4408 | Fax +44 (0) 845 299 1517 40 [email protected] © Clinical Innovations, LLC. | All rights reserved for for for November 14 - 17, 2018| Venice, Italy astraia member of

Data matters To you To your patient

astraia has around 500 installations worldwide and has generated a unique terminology and workflow in over 25 languages. Our expertise is based on research from the Fetal Medi- cine Foundation and numerous scientists and clinicians around the world.

The following modules have been expertly developed for nearly 20 years: New Intrapartum + Obstetrics: covers ultrasound and clinical examinations, history, invasive procedures, laboratory and risk assessments for Trisomies, Preeclampsia, Ultrasound Fetal Growth Retardation and Pre-Term Delivery. For more + Gynaecology: Clinical and ultrasound examinations, maternal structures, information visit kidney and bladder, endoscopic procedures, laboratory. www.astraia.com Strong focus on examination report printouts, statistical analysis of data, or contact us at user-friendly and intuitive interface as well as user training. [email protected] 41 NOTE

42 November 14 - 17, 2018| Venice, Italy

NOTE

nd world 2congress VENUE

QUEEN ELIZABETH II Congress Centre Broad Sanctuary,Westminster London SW1P 3EE, UK