EDUCATION CURRICULUM VITAE  B.Sc. degree: Faculty of Science, Minia University, (2006).  I was the 1st in the ranking of Zoology Department (class members 64 students) with a final grade: Excellent degree (85.92 %).

 Master 1 degree: Faculty of Science, Minia University, Egypt (2007).  With a final grade: Very good (80.5%).

 Master 2 degree: Faculty of Science, Minia University, Egypt (2011).  Under title: “Bioactivity of some plant extracts against the Dr. TAREK M. ABD EL-AZIZ carpet beetle Attagenus fasciatus (Thunberg) (Coleoptera: Dermestidae)”.

PROFILE  Ph.D. degree: Grenoble Institute of Neurosciences, Grenoble Alpes University, France (2016). I am Assistant Professor of  Under title: “New technologies for venoms: Neurotoxicology at Minia University, proteomics, drug screening and toxin neutralization”. Egypt. I started working on animal toxins during my PhD studies at  Postdoctoral JSPS fellowship: Kyoto University, Japan (2018). Grenoble Alpes University, France,  Project title: “Pharmacological regulation of inflammation via where I researched the nature and transient receptor potential melastatin 2 channels by animal pharmacology of the animal toxins with toxins ”. a particular focus on neurotoxins and  Postdoctoral NIH fellowship: University of Texas Health Science toxin neutralization. After 4 years within Center San Antonio, Texas, USA. (2019). the Grenoble Institute of Neurosciences  Project title: “Regulation of ENaC by Casein Kinase 2”. and 6 months at Kyoto University WORK EXPERIENCES following this line of research, I moved to Univ. of Texas Health Science Center  Demonstrator: Zoology and Entomology Department, Faculty of at San Antonio, Texas, USA, to initiate Science, Minia University, Egypt. (From 21/06/2007 to 26/12/2011). research into the neuropharmacology of Egyptian animal venoms.  Assistant Lecturer: Zoology and Entomology Department, Faculty of Science, Minia University, Egypt. (From 27/12/2011 to 12/03/2013). CONTACT ME  Ph.D. student: Grenoble Institute of Neurosciences, Grenoble Alpes University, France. (From 13/03/2013 to 25/07/2016). +1(210)-461-1771  Assistant Professor: Department of Molecular Biology, Kyoto [email protected] University, Japan. (From 15/06/2018 to 15/12/2018). [email protected]  Lecturer: Zoology and Entomology Department, Faculty of Science, Minia University, Egypt. (From 31/10/2016 to 30/06/2019). Tarekabdelaziz85  Senior Postdoctoral Fellow: Univ. of Texas Health Science Center San Antonio, Texas, USA. (From 01/07/2019 to Now). www.Exp-therapeutics.com LANGUAGES  Arabic 1- Department of Cellular and  Native language Integrative Physiology, Univ. of Texas Health Science Center at San  English Antonio, TX 78229-3900, USA.  Excellent command of English (Spoken and Written). 2- Zoology Department, Faculty of Science, Minia University, 61519  French El-Minia, Egypt.  Good command of French (Spoken). RESEARCH INTERESTS

 Animal toxins  Antivenoms production  Electrophysiology

venoms  Aptamers  Epithelial Na+ Channels

 Peptide biochemistry  Proteomics  Kidney Diseases

 Drug design  Mass spectrometry  Antimicrobial

 Ion channel targeting and imaging  Neuropharmacology

 TRPM2 channel  Drug abuse and addiction PROFESSIONAL SKILLS

 I contribute to delivery of various undergraduate and postgraduate modules at Faculty of Science, Minia University, Egypt. (From 2007 to 2013 & from 2016 to 2019).  Neurosciences, Toxicology, Immunohistochemistry, Immunology, Animal physiology, Cell biology, Histology, Biotechnology, Human biology, Comparative anatomy, , Insect physiology, Biological control with natural products and Parasitology.

 In addition to the above, I supervise undergraduate (3rd and 4th year) for their training program (Annually from 2010 to 2012 & from 2016 to 2019) in hospitals and agriculture research centers.

SCIENTIFIC CONFERENCES & WORKSHOPS

 Oral presentation: The 6th International Symposium Aptamers 2019, Oxford, UK. (03rd to 4th April 2019) under title: From antibodies to chemical synthetic DNA “aptamers”: Next Generation therapy for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology.

 Poster presentation: The 49th NIPS International Symposium ‘Ion Channels: Looking back, Seeing ahead’, Okazaki Conference Center, Okazaki, Japan. (05th to 08th December 2018) under title: TRPM2 channel- STAT3 complex regulates the polarity of tumor-associated macrophage and tumor angiogenesis.

 Poster presentation: 10th HOPE Meeting with Nobel Laureates. Japan Society for the Promotion of Science (JSPS), Yokohama, Japan. (12th to 15th March 2018) under title: Examination of novel neuro- pharmacotherapeutics for drug abuse and addiction: focus on neuro bioactive animal toxin peptides.

 Listener: Nobel Prize Dialogue in Tokyo, Japan (11th March 2018), where Nobel Laureates, key opinion leaders, policy makers, students, researchers and the general public met to discuss The Future of Food.

 Oral presentation: 7th International Conference on Natural Toxins of the Egyptian Society of Natural Toxins. Faculty of Science, Suez Canal University, Ismailia, Egypt. (13th to 14th December 2016) under title: Single- stranded DNA aptamers as a new approach to neutralize the in vivo lethality of αC-conotoxin PrXA.

 Poster presentation: International symposium “Aptamers in Bordeaux”. Bordeaux Université, Bordeaux, France. (24th to 25th June 2016) under title: Functional neutralization of αC-conotoxin PrXA by aptamers.

 Oral presentation: LABEX ICST meeting for researchers. Institut de Génomique Fonctionnelle, Montpellier, France. (30th to 02nd December 2015) under title: Functional neutralization of αC-conotoxin by aptamers.

 Poster presentation: 1st LABEX ICST meeting for doctoral students and postdoctoral fellows. Lille university, Lille, France. (29th to 30th October 2014) under title: Venom proteomic analyses of the Egyptian snake aegyptia (Black Desert ).

 Poster presentation: LABEX ICST meeting for researchers. Grenoble Institute of Neurosciences, Joseph Fourier university, Grenoble, France. (25th to 27th November 2013) under title: Fractionation methods of venom peptides from the Egyptian snake Walterinnesia aegyptia.

 Oral presentation: 19th International Scientific Conference of the Egyptian Germany Society of Zoology. Faculty of Science, Beni-Sueif University, Beni-Sueif, Egypt. (30th April to 02nd May 2011) under title: The bioactivity of some plant extracts against the carpet beetle Attagenus fasciatus (Thunberg) (Coleoptera: Dermestidae).

 Workshops under title: Scientific Research Methods, Scientific Research polity, Scientific Research Ethics, International Publication, Management of Timing and Meeting & Effective Presentation Skills.

SCIENTIFIC ACHIEVEMENTS

 Postdoctoral fellowship from the National Institutes of Health (NIH) for 1 year at University of Texas Health Science Center at San Antonio, Texas, USA (From July 2019 to June 2020).

 Postdoctoral fellowship from the Japan Society for the Promotion of Science (JSPS) for 6 months at Graduate School of Engineering, Kyoto University, Japan (From June 2018 to December 2018).

 Best Team Presentation Award during the 10th HOPE Meeting with Nobel Laureates. Japan Society for the Promotion of Science (JSPS), 12th to 15th March 2018, Yokohama, Japan.

 Doctoral scholarship granted from the Egyptian government and French National Institute of Health and Medical Research (INSERM) to acquire PhD in Neurotoxicology from Grenoble Alpes University, France (From 2013 to 2016). LIST OF PUBLICATIONS

 Abd El-Aziz T. M. and Stockand, J. D.: Recent progress and challenges in drug development against COVID- 19 coronavirus (SARS-CoV-2) - an update on the status. Infection, Genetics and Evolution (2020) 83, 104327.

 Abd El-Aziz T. M., Shoulkamy, M. I., Hegazy, M. A., Mahmoud, A. and Mashaly, A. M.: Comparative study of the in vivo toxicity and pathophysiology envenomation of three medically important Egyptian snake venoms. Archives of Toxicology (2020) 94 (1), 335-344.

 Abd El-Aziz T. M., Soares, A. G. and Stockand, J. D.: Snake Venoms in Drug Discovery: Valuable Therapeutic Tools for Life Saving. Toxins (2019) 11(10), 564.

 Sotoing Taiwe G., Montnach J., Nicolas S., De Waard S., Fiore E., Peyrin E., Abd El-Aziz T. M., Amar M., Molgó J., Ronjat M., Servent D., Ravelet C., De Waard M.: Aptamer Efficacies for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology. Molecules (2019) 24(2), 229.

 Abd El-Aziz T. M., Al Khoury S., Jaquillard L., Triquigneaux M., Martinez G., Bourgoin-Voillard S., Sève M., Arnoult C., Beroud R. and De Waard M.: Identification of actiflagelin, a sperm activator from the venom of the Egyptian black snake Walterinnesia aegyptia. Journal of Venomous and Toxins including Tropical Diseases (2018) 24:2.

 Abd El Aziz T. M., Ravelet C., Molgo J., Fiore E., Pale S., Amar M., Al-khoury S., Dejeu J., Fadl M., Ronjat M., Sotoing Taiwe G., Servent D., Peyrin E., De Waard M.: Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides. Scientific Reports, 2017. 7(1): p. 7202.

 Martinez G., Hograindleur JP., Voisin S., Abi Nahed R., Abd El Aziz T.M., Escoffier J., Bessonnat J., Fovet CM., De Waard M., Hennebicq S., Aucagne V., Ray P.F., Schmitt1 E., Bulet P., Arnoult C.: Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus, improves sperm motility and fertilization in different mammalian species. Mol Hum Reprod (2017) 23 (2): 116-131.

 Abd El Aziz T. M., Bourgoin-Voillard S., Combemale S., Beroud R., Fadl M., Seve M., De Waard M.: Fractionation and proteomic analysis of the Walterinnesia aegyptia snake venom using OFFGEL and MALDI-TOF-MS techniques. Electrophoresis, 2015, 36 (20): 2594-605.

 Dardevet L., Rani D., Abd El Aziz T. M., Bazin I., Sabatier J., Brambilla E., and De Waard M.: Chlorotoxin: A Helpful Natural Scorpion Peptide to Diagnose Glioma and Fight Tumor Invasion. Toxins 2015, 7(4), 1079-1101.

 Ali, M. F., Mashaly A. M. and Abd El Aziz T. M.: The bioactivity of some plant extracts against the carpet beetle Attagenus fasciatus (Thunberg). J. Egypt. Ger. Soc. Zool. 63 (2011), 71 – 98.

 Abd El-Aziz T. M., Jaquillard L., Bourgoin-Voillard S., Martinez G., Triquigneaux M., Combemale S., Hograindleur J., Escoffier J., Michelland S., Bulet P., Beroud R., Seve M., Arnoult C., De Waard M.: Sequence identification and chemical synthesis of a sperm motility activator from the Egyptian black snake Walterinnesia aegyptia venom. Journal of Medicinal Chemistry (Accepted 2019).

Membership

 Membership in professional societies:  International Society on Aptamers (INSOAP)  Egyptian Society of Natural Toxins  International Society of Toxinology (IST)  American Society of Physiology (APS)

 Scientific Reviewer:  Internationally: Toxins, Applied Biochemistry and Biotechnology Journal, Comparative Biochemistry and Physiology, Part C, Charity, EC Pharmacology and Toxicology Journal  Nationally: Egyptian Journal of Natural Toxins

 Scientific Editor:  Internationally: SCIREA Journal of Biology

REFEREES  Prof. James D. Stockand, Full Professor  University of Texas health Science Center San Antonio, Texas, USA  Tel.: +1  E-mail: [email protected]

 Prof. Yasuo Mori, Full Professor  Department of Synthetic and Biological Chemistry, Kyoto University, Kyoto, Japan  Tel.: +81-75-383-2761  E-mail: [email protected]

 Dr. Michel De Waard, Research Director  Institute of Thorax, University of Nantes, Nantes, France.  Smartox Biotechnology, Saint-Martin d’Hères, France.  Tel. : +33 (0) 6 60 76 33 75  E-mail : [email protected]

 Dr. Corinne Ravelet, Assistant Professor  Molecular Pharmacochemistry Department, Grenoble Alpes University, Saint Martin D’Hére, France.  Tel. : +33 (0) 4 76 63 53 06  E-mail : [email protected]

 Prof. Mahmoud Fadl, Full Professor  Zoology Department, Faculty of Science, Minia University, El-Minia, Egypt.  Tel. : +2 01020646409  E-mail : [email protected]