Summary Detecting Carbon Monoxide Poisoning in the Emergency
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Solutions for COVID-19 Surge Capacity Monitoring
Solutions for COVID-19 Surge Capacity Monitoring Secure Cloud-based Patient Monitoring with Tetherless Hospital-grade Technology and the Masimo SafetyNet™ Data Capture and Surveillance Platform The COVID-19 pandemic has created increased demand across the globe for home-based monitoring and patient engagement solutions. The Masimo SafetyNet solution provides continuous tetherless oxygen saturation, respiration rate, and temperature measurements coupled with a patient surveillance platform. Seamlessly Extend Care from the Hospital to the Home Tetherless Pulse Oximetry with Respiration Rate and Temperature Measurements Masimo SafetyNet Powered by Masimo SET® measure-through-motion technology, the tetherless single-patient-use sensor provides Masimo SafetyNet is a secure cloud-based platform that allows providers to remotely manage patients using continuous respiration rate and oxygen saturation measurements, with a second tetherless sensor, Radius T°*, customized interactive digital CarePrograms. for continuous temperature measurements. Patient data is sent securely via Bluetooth to the Masimo SafetyNet mobile application. CarePrograms CarePrograms offer a digital replacement for traditional home-care plans and are delivered to patients’ smartphones via an app. The CareProgram actively reminds patients to follow their care plan, automatically captures measurement data Remote Home Monitoring Kit from the tetherless sensors, and securely pushes the data to clinicians at the hospital for evaluation. Masimo has created Patients receive a multi-day -
18,8 Quaternary Structure of Proteins
570 CHAPTERt8 Amino Acids,Peptides, and Proteins 18,8Quaternary structure of proteins AIMS: Todefine the termssubunit dnd quaternarystructure. Io describethe quoternorystructure of hemoglobin.To distinguishomong oxyhemoglobin,deoxyhemoglobin, ond methemoglobin. Someproteins consist of more than one pollpeptide chain. Theseindiuid- ual chains are calledsubunits of the protein. Proteins composedof subunits In some proteins, polypeptide are said to haue quaternary structure. Many proteins have structures that chains aggregateto form contain subunits. Proteins consistingof dimers (two subunits), tetramers quaternary structures. (four subunits), and hexamers (six subunits) are fairly common. The pro- teins that comprise the individual subunits may be identical, or they may be different. Like the secondary and tertiary structures, the quaternary structure of a protein is determined by its primary structure. The pollpep- tide chains of subunits are held in place by the same forces that determine tertiary structure-hydrogen bonds, salt bridges, and sometimes disulfide bridges-except the forces are betweenthe polypeptide chains of the sub- units instead of within them. Hydrophobic aliphatic and aromatic side chains of subunits can aggregateto exclude water. Hemoglobin-the globular oxygen-transport protein of blood-is an example of a protein that has a quaternary structure. Max Perutz, also of the Medical ResearchCouncil laboratories,determined the structure of horse blood hemoglobin in 1959.Hemoglobin is a larger molecule than myoglo- bin. The hemoglobin molecule has a molar mass of 64,500.It contains about 5000 individual atoms, excluding hydrogens, in 574 amino acid residues. The quaternary structure of hemoglobin consistsof four peptide sub- units. TWo of the subunits are identical and are called the alpha subunits. -
The History of Carbon Monoxide Intoxication
medicina Review The History of Carbon Monoxide Intoxication Ioannis-Fivos Megas 1 , Justus P. Beier 2 and Gerrit Grieb 1,2,* 1 Department of Plastic Surgery and Hand Surgery, Gemeinschaftskrankenhaus Havelhoehe, Kladower Damm 221, 14089 Berlin, Germany; fi[email protected] 2 Burn Center, Department of Plastic Surgery and Hand Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany; [email protected] * Correspondence: [email protected] Abstract: Intoxication with carbon monoxide in organisms needing oxygen has probably existed on Earth as long as fire and its smoke. What was observed in antiquity and the Middle Ages, and usually ended fatally, was first successfully treated in the last century. Since then, diagnostics and treatments have undergone exciting developments, in particular specific treatments such as hyperbaric oxygen therapy. In this review, different historic aspects of the etiology, diagnosis and treatment of carbon monoxide intoxication are described and discussed. Keywords: carbon monoxide; CO intoxication; COHb; inhalation injury 1. Introduction and Overview Intoxication with carbon monoxide in organisms needing oxygen for survival has probably existed on Earth as long as fire and its smoke. Whenever the respiratory tract of living beings comes into contact with the smoke from a flame, CO intoxication and/or in- Citation: Megas, I.-F.; Beier, J.P.; halation injury may take place. Although the therapeutic potential of carbon monoxide has Grieb, G. The History of Carbon also been increasingly studied in recent history [1], the toxic effects historically dominate a Monoxide Intoxication. Medicina 2021, 57, 400. https://doi.org/10.3390/ much longer period of time. medicina57050400 As a colorless, odorless and tasteless gas, CO is produced by the incomplete combus- tion of hydrocarbons and poses an invisible danger. -
The Role of Methemoglobin and Carboxyhemoglobin in COVID-19: a Review
Journal of Clinical Medicine Review The Role of Methemoglobin and Carboxyhemoglobin in COVID-19: A Review Felix Scholkmann 1,2,*, Tanja Restin 2, Marco Ferrari 3 and Valentina Quaresima 3 1 Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland 2 Newborn Research Zurich, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland; [email protected] 3 Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy; [email protected] (M.F.); [email protected] (V.Q.) * Correspondence: [email protected]; Tel.: +41-4-4255-9326 Abstract: Following the outbreak of a novel coronavirus (SARS-CoV-2) associated with pneumonia in China (Corona Virus Disease 2019, COVID-19) at the end of 2019, the world is currently facing a global pandemic of infections with SARS-CoV-2 and cases of COVID-19. Since severely ill patients often show elevated methemoglobin (MetHb) and carboxyhemoglobin (COHb) concentrations in their blood as a marker of disease severity, we aimed to summarize the currently available published study results (case reports and cross-sectional studies) on MetHb and COHb concentrations in the blood of COVID-19 patients. To this end, a systematic literature research was performed. For the case of MetHb, seven publications were identified (five case reports and two cross-sectional studies), and for the case of COHb, three studies were found (two cross-sectional studies and one case report). The findings reported in the publications show that an increase in MetHb and COHb can happen in COVID-19 patients, especially in critically ill ones, and that MetHb and COHb can increase to dangerously high levels during the course of the disease in some patients. -
Pathophysiology of Acid Base Balance: the Theory Practice Relationship
Intensive and Critical Care Nursing (2008) 24, 28—40 ORIGINAL ARTICLE Pathophysiology of acid base balance: The theory practice relationship Sharon L. Edwards ∗ Buckinghamshire Chilterns University College, Chalfont Campus, Newland Park, Gorelands Lane, Chalfont St. Giles, Buckinghamshire HP8 4AD, United Kingdom Accepted 13 May 2007 KEYWORDS Summary There are many disorders/diseases that lead to changes in acid base Acid base balance; balance. These conditions are not rare or uncommon in clinical practice, but every- Arterial blood gases; day occurrences on the ward or in critical care. Conditions such as asthma, chronic Acidosis; obstructive pulmonary disease (bronchitis or emphasaemia), diabetic ketoacidosis, Alkalosis renal disease or failure, any type of shock (sepsis, anaphylaxsis, neurogenic, cardio- genic, hypovolaemia), stress or anxiety which can lead to hyperventilation, and some drugs (sedatives, opoids) leading to reduced ventilation. In addition, some symptoms of disease can cause vomiting and diarrhoea, which effects acid base balance. It is imperative that critical care nurses are aware of changes that occur in relation to altered physiology, leading to an understanding of the changes in patients’ condition that are observed, and why the administration of some immediate therapies such as oxygen is imperative. © 2007 Elsevier Ltd. All rights reserved. Introduction the essential concepts of acid base physiology is necessary so that quick and correct diagnosis can The implications for practice with regards to be determined and appropriate treatment imple- acid base physiology are separated into respi- mented. ratory acidosis and alkalosis, metabolic acidosis The homeostatic imbalances of acid base are and alkalosis, observed in patients with differing examined as the body attempts to maintain pH bal- aetiologies. -
Masimo SET Bibliography Brochure
Select Bibliography of Published Articles and Abstracts Pulse Oximetry Pulse CO-Oximetry rainbow Acoustic Monitoring® Brain Monitoring For a listing of over 500 available citations, go to the clinical evidence section of www.masimo.com Table of Contents by Technology and Measurement 01: Pulse Oximetry Oxygenation (SpO2), Pulse Rate (PR) ................................. 1-17 Perfusion Index (Pi) ................................................ 18-21 Pleth Variability Index (PVi®) ........................................ 22-34 Patient SafetyNet™ ................................................ 35-37 02: Pulse CO-Oximetry Total Hemoglobin (SpHb®) ......................................... 38-48 03: rainbow Acoustic Monitoring Acoustic Respiration Rate (RRa®) .................................... 49-56 04: Brain Monitoring SedLine® ......................................................... 57-60 O3® ............................................................. 61-62 Table of Contents Oxygenation (SpO2), Pulse Rate (PR) 17 Differences in Pulse Oximetry Technology Can Affect Detection of Sleep-Disordered Breathing in Children Brouillette RT, Lavergne J, Leimanis A, Nixon GM, Ladan S, McGregor CD. Anesth Analg. 2002;94(1 Suppl):S47-53. 01 Temporal Quantification of Oxygen Saturation Ranges: An Effort to Reduce Hyperoxia in the Neonatal Intensive Care Unit Bizzarro MJ, Li FY, Katz K, Shabanova V, Ehrenkranz RA, Bhandari V. J Perinatol. 2014 Jan;34(1):33-8. Perfusion Index (Pi) 18 Noninvasive Peripheral Perfusion Index as a Possible Tool for Screening for Critical Left Heart Obstruction 02 Pulse Oximetry with Clinical Assessment to Screen for Congenital Heart Disease in Neonates in China: Granelli AW, Ostman-Smith I. Acta Paediatr. 2007;96(10):1455-9. A Prospective Study Zhao QM, Ma XJ, Ge XL, Liu F, Yan WL, Wu L, Ye M, Liang XC, Zhang J, Gao Y, Jia B, Huang GY. Neonatal Congenital Heart Disease Screening Group. 19 The Perfusion Index Derived from a Pulse Oximeter for Predicting Low Superior Vena Cava Flow in The Lancet. -
Elevated Carboxyhemoglobin in a Marine Mammal, the Northern
© 2014. Published by The Company of Biologists Ltd | The Journal of Experimental Biology (2014) 217, 1752-1757 doi:10.1242/jeb.100677 RESEARCH ARTICLE Elevated carboxyhemoglobin in a marine mammal, the northern elephant seal Michael S. Tift1,2,*, Paul J. Ponganis1 and Daniel E. Crocker2 ABSTRACT storage capacity (decreased arterial O2 content), thus limiting Low concentrations of endogenous carbon monoxide (CO), mitochondrial respiration. However, CO is also generated generated primarily through degradation of heme from heme- endogenously in low concentrations, and functions in proteins, have been shown to maintain physiological function of neurotransmission and in protection of tissues and cells against organs and to exert cytoprotective effects. However, high inflammation, apoptosis and ischemia–reperfusion injuries (Snyder concentrations of carboxyhemoglobin (COHb), formed by CO binding et al., 1998; Kevin and Laffey, 2008; Mustafa et al., 2009; Kajimura to hemoglobin, potentially prevent adequate O2 delivery to tissues by et al., 2010; Prabhakar, 2012). Therefore, low concentrations of CO lowering arterial O2 content. Elevated heme-protein concentrations, can provide beneficial and therapeutic effects up to a specific as found in marine mammals, are likely associated with greater heme concentration, at which elevated CO then leads to detrimental effects degradation, more endogenous CO production and, consequently, from reduced O2 delivery. These relatively recent findings give CO elevated COHb concentrations. Therefore, we measured COHb in a new functional perspective and emphasize the importance of elephant seals, a species with large blood volumes and elevated understanding the biological effects of specific CO concentrations hemoglobin and myoglobin concentrations. The levels of COHb were in the body which can be viewed as therapeutic. -
Rad-67™ Pulse CO-Oximeter®
Rad-67™ Pulse CO-Oximeter® Featuring Masimo SET® Measure-through Motion* and Low Perfusion™ Pulse Oximetry and Noninvasive Total Hemoglobin (SpHb®) Spot-check Monitoring SpO2 Oxygen Saturation* PR Pulse Rate* Pi Perfusion Index SpHb® Total Hemoglobin** More Than a Conventional Pulse Oximeter Compatible with the Display spot-check monitoring results with Label spot-check monitoring measurements rainbow® DCI®-mini sensor signal quality indicators for signal stability, with unique patient identifiersfor convenient low perfusion, and ambient light interference historical data review directly on the device * Masimo SET® Measure-through Motion technology includes SpO2 and PR. ** SpHb indicated for adult patients only. Masimo SET® Combined with Next Generation SpHb Spot-check Monitoring Technology1 © 2019 Masimo.© 2019 All rights reserved. 4 4 4 Measure SpHb, SpO2, pulse rate (PR), and perfusion index On-screen guidance to Results displayed in (Pi) using the rainbow® automate workflow as few as 30 seconds DCI-mini sensor ** Features HD Display • Bright LCD, color display • Automatic low power mode to conserve power Intuitive touchscreen allows users to Redesigned sensor connector port Auto-Brightness quickly navigate the user interface with with a slim profile design provides tactile • Ambient light sensor finger gestures feedback upon proper connection automatically adjusts screen brightness to optimize visibility Rechargeable Battery • Li-ion Battery • Up to 6 hours battery life2 • 6 hours charging time Wireless printer compatibility enables -
Ethylene Glycol Ingestion Reviewer: Adam Pomerlau, MD Authors: Jeff Holmes, MD / Tammi Schaeffer, DO
Pediatric Ethylene Glycol Ingestion Reviewer: Adam Pomerlau, MD Authors: Jeff Holmes, MD / Tammi Schaeffer, DO Target Audience: Emergency Medicine Residents, Medical Students Primary Learning Objectives: 1. Recognize signs and symptoms of ethylene glycol toxicity 2. Order appropriate laboratory and radiology studies in ethylene glycol toxicity 3. Recognize and interpret blood gas, anion gap, and osmolal gap in setting of TA ingestion 4. Differentiate the symptoms and signs of ethylene glycol toxicity from those associated with other toxic alcohols e.g. ethanol, methanol, and isopropyl alcohol Secondary Learning Objectives: detailed technical/behavioral goals, didactic points 1. Perform a mental status evaluation of the altered patient 2. Formulate independent differential diagnosis in setting of leading information from RN 3. Describe the role of bicarbonate for severe acidosis Critical actions checklist: 1. Obtain appropriate diagnostics 2. Protect the patient’s airway 3. Start intravenous fluid resuscitation 4. Initiate serum alkalinization 5. Initiate alcohol dehydrogenase blockade 6. Consult Poison Center/Toxicology 7. Get Nephrology Consultation for hemodialysis Environment: 1. Room Set Up – ED acute care area a. Manikin Set Up – Mid or high fidelity simulator, simulated sweat if available b. Airway equipment, Sodium Bicarbonate, Nasogastric tube, Activated charcoal, IV fluid, norepinephrine, Simulated naloxone, Simulate RSI medications (etomidate, succinylcholine) 2. Distractors – ED noise For Examiner Only CASE SUMMARY SYNOPSIS OF HISTORY/ Scenario Background The setting is an urban emergency department. This is the case of a 2.5-year-old male toddler who presents to the ED with an accidental ingestion of ethylene glycol. The child was home as the father was watching him. The father was changing the oil on his car. -
June 29, 2021 Via EDIS the Honorable Lisa
1717 Pennsylvania Ave. N.W., Ste. 900, Washington D.C. 20006 T (202) 640-6400 Jonathan E. Bachand [email protected] June 29, 2021 Via EDIS The Honorable Lisa R. Barton Secretary U.S. International Trade Commission 500 E Street, S.W. Washington, D.C. 20436 Re: In the Matter of Certain Light-Based Physiological Measurement Devices and Components Thereof ITC Inv. No. 337-TA-_____ Dear Secretary Barton: Enclosed for filing, please find documents in support of a request by Complainants Masimo Corporation and Cercacor Laboratories, Inc. (collectively, “Complainants”) that the U.S. International Trade Commission (“Commission”) institute an investigation pursuant to the provisions of Section 337 of the Tariff Act of 1930, as amended, 19 U.S.C. § 1337 concerning certain light-based physiological measurement devices and components thereof. Please note that the Complaint, Complainants’ Statement on the Public Interest, and certain Confidential Exhibits 11, 15-28, and 30 contain Confidential Business Information and, pursuant to the Commission’s Rules of Practice and Procedure, a separate letter requesting confidential treatment of the information accompanies this filing. On March 16, 2020, the Commission provided “notice that it is temporarily waiving and amending certain of the Commission’s rules that required the filing of paper copies, CD-ROMS, and other physical media in section 337 investigations to address concerns about COVID-19.” International Trade Commission, Temporary Changes to Filing Procedures, Federal Register Vol. 85, No. 54 (March 19, 2020). Specifically, the Commission approved the temporary amendment of various rules “to permit parties to file section 337 complaints, exhibits, attachments, and appendices, electronically.” Id. -
HANDOUT #1 CONCEPT INTRODUCTION PRESENTATION: PERFUSION Topic Description Definition of Perfusion the Passage of Oxygenated Capi
HANDOUT #1 CONCEPT INTRODUCTION PRESENTATION: PERFUSION Topic Description Definition of Perfusion The passage of oxygenated capillary blood through body tissues. Peripheral perfusion is passage (flow) of blood to the extremities of the body. Central perfusion is passage (flow) of blood to major body organs, including the heart and lungs. Scope of Perfusion Perfusion can be viewed on a continuum as adequate on one end and inadequate, decreased, or impaired on the other. Decreased Perfusion can range from minimal to severe. Ischemia refers to decreased Perfusion, while infarction is complete tissue death due to severe decreased Perfusion. Risk Factors/Populations at Risk for Examples of risk factors or populations at risk Impaired Perfusion for impaired Perfusion can be categorized as modifiable (can be changed) and nonmodifiable (cannot be changed) Modifiable factors include: • Obesity • Lack of physical activity/sedentary lifestyle • Smoking Nonmodifiable factors include age, gender, and race/ethnicity. Groups at risk for impaired Perfusion include those who are of advanced age (due to less elastic arterial vessels as a result of aging) and those who are African American and Hispanic. These racial/ethnic groups are most at risk for chronic diseases that can affect Perfusion such as diabetes mellitus, hypertension, hyperlipidemia, and peripheral vascular disease. The cause of these variations is not known, but dietary and environmental factors may contribute to the higher incidence of chronic disease in these groups. Newborns and infants who have congenital heart anomalies are also at risk for impaired central Perfusion. Many of these defects can be surgically repaired to regain adequate Perfusion. Physiologic Consequences of Impaired Consequences of impaired Perfusion vary Perfusion depending on the degree of impairment. -
Pleth Variability Index: a Dynamic Measurement to Help Assess to Help Measurement a Dynamic Index: Variability Pleth Responsiveness and Fluid Physiology
Pleth Variability Index: A Dynamic Measurement to Help Assess TECHNICAL BULLETIN TECHNICAL Physiology and Fluid Responsiveness SUMMARY PVI®, an index available with Masimo SET® pulse oximetry, is the first and only noninvasive, continuous, easy-to-use method to help clinicians manage fluid responsiveness in sedated patients under positive pressure ventilation. Other clinical uses have also been developed for PVI, including helping clinicians to assess the effects of positive end expiratory pressure on cardiac index and to identify patients at risk for hypotension during anesthesia induction. PVI, along with the other innovative noninvasive monitoring technologies available with the Masimo rainbow SET® platform (SpHb®, SpCO®, SpMet®, RRa™), has helped clinicians to realize improved patient outcomes while lowering the cost of care. INTRODUCTION Many pulse oximetry technologies display a processed and filtered representation of the photoplethysmosgraphic waveform. Each manufacturer uses unique proprietary algorithms to calculate the waveform displayed on the pulse oximeter. Masimo has extracted and processed information from the waveform to create two physiologic indices, perfusion index (PI) and pleth variability index (PVI). PI is calculated by indexing the infrared (IR) pulsatile signal against the nonpulsitile signal and expressing this number as a percentage. Masimo SET® PI has been shown to be useful to gauge the severity of illness in newborns1, 2 to assess the effectiveness of epidural blocks3, 4 to indicate successful interscalene nerve block placement in awake patients5 and to quantify peripheral perfusion for diagnosis of congenital heart disease in newborns.6 PVI is the first and only commercially available measurement that automatically and continuously calculates the respiratory variations in the photoplethysmosgraphic waveform.