ACTR1A Antibody Cat. No.: 27-161

ACTR1A Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Dog, Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human ACTR1A.

TESTED APPLICATIONS: ELISA, WB

ACTR1A antibody can be used for detection of ACTR1A by ELISA at 1:62500. ACTR1A APPLICATIONS: antibody can be used for detection of ACTR1A by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

POSITIVE CONTROL: 1) Cat. No. 1219 - MCF7 Cell Lysate

PREDICTED MOLECULAR 41 kDa WEIGHT:

Properties

PURIFICATION: Antibody is purified by peptide affinity chromatography method.

CLONALITY: Polyclonal

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

September 24, 2021 1 https://www.prosci-inc.com/actr1a-antibody-27-161.html Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.

CONCENTRATION: batch dependent

For short periods of storage (days) store at 4˚C. For longer periods of storage, store STORAGE CONDITIONS: ACTR1A antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Additional Info

OFFICIAL SYMBOL: ACTR1A

ALTERNATE NAMES: ACTR1A, ARP1, CTRN1

ACCESSION NO.: NP_005727

PROTEIN GI NO.: 5031569

GENE ID: 10121

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

ACTR1A is a 42.6 kD subunit of , a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both and cytoplasmic . It is involved in a diverse array of cellular functions, including ER-to- Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an -related , and is approximately 60% identical at the amino acid level to conventional actin.This encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. BACKGROUND: Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin- related protein, and is approximately 60% identical at the amino acid level to conventional actin. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

REFERENCES: 1) Sugarbaker, D.J., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (9), 3521-3526.

ANTIBODIES FOR RESEARCH USE ONLY.

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