Curriculum Vitae Kan Ding, MD

PERSONAL

Title: Assistant Professor Office Department of Neurology and Neurotherapeutics Address: UT Southwestern Medical Center at Dallas 5323 Harry Hines Blvd Dallas, TX 75390-8508

Work Phone: 214-648-2315 Work Fax: 214-648-6320 Work Email: [email protected] Place of birth: P. R. China Citizenship: United States

EDUCATION

Medical school

1989-1997 Peking Union Medical College MD

Postdoctoral Training

2000-2003 University of Rochester Post-doctoral training 2003-2006 UT Southwestern Medical Center NIH Research Fellow

2008-2012 UT Southwestern Medical Center Residency in Neurology 2012-2013 UT Southwestern Medical Center Fellowship in Neurophysiology 2013- 2014 UT Southwestern Medical Center Fellowship in

BOARD CERTIFICATION and LICENSURE

2005 ECFMG Certificate 2011 California Medical Board 2012 American Board of Psychiatry and Neurology 2013 American Board of Clinical Neurophysiology 2013 Texas Medical Board 2014 American Board of Epilepsy

MAJOR HONORS AND AWARDS

2010 Victor Riberg/Leon Weisberg Award 1st place For outstanding research manuscript presented by a neurology resident

ACADEMIC APPOINTMENTS

2013 Assistant Instructor, UT Southwestern Medical Center Kan Ding, MD 2 ______

2014 Assistant Professor, UT Southwestern Medical Center

HOSPITAL or AFFILIATED INSTITUTIONAL APPOINTMENTS

2013 Parkland Memorial Hospital Zale Lipshy University Hospital Clements University Hospital 2014 Lifecare Hospitals at Dallas

ADMINISTRATIVE RESPONSIBILITIES, COMMITTEES and SERVICE

Hospital 2014 Medical Director in Parkland Epilepsy Clinic

CLINICAL ACTIVITIES

Clinical practice and past clinical contributions

2012-2013 Epilepsy Fellow 2014- Current Attending physician in Epilepsy Monitoring Unit Attending physician in Clinical Neurophysiology Lab Attending physician in Neurology 2014- Current Parkland Epilepsy Clinic Medical Director

EDUCATIONAL ACTIVITIES and RESPONSIBILITIES

Current and Past Teaching Responsibilities

06/03/2013 EMU orientation- Neurology Resident 06/04/2013 Basic EEG – Neurology Resident 04/01/2014 Evoked Potential – Brain Awareness Week (Medical students) 2014-2015 Resident EMU Rotation Codirector 2014-2015 Resident EEG Rotation Codirector 06/03/2014 Resident Orientation Lecture – EMU Orientation 07/21/2014 Resident ER Lecture – 09/05/2014 Resident Neurophysiology Lecture – /MTS 04/24/2015 Fellow Neurophysiology Lecture – Women with Epilepsy 2015-2016 Resident EMU Rotation Codirector 2015-2016 Resident EEG Rotation Codirector 06/17/2015 Resident Orientation Lecture – EMU Orientation 06/18/2015 Resident Orientation Lecture – Basic EEG 06/22/2015 BootCamp: Neuro Examination Kan Ding, MD 3 ______

07/20/2015 Resident ER Lecture – Status Epilepticus 08/31/2015 Resident Neurophysiology Lecture- Normal and abnormal EEG adult 03/11/2016 Fellow Neurophysiology Lecture- Women with Epilepsy 2016-2017 Resident EMU Rotation Codirector 2016-2017 Resident EEG Rotation Codirector 06/17/2016 Resident Orientation Lecture – EMU Orientation 06/21/2016 Resident Orientation Lecture – Basic EEG 07/19/2016 Resident ER Lecture – Status Epilepticus 08/31/2016 Resident Neurophysiology Lecture- Normal and abnormal EEG adult

PROFESSIONAL SOCIETIES

2008- Current American Academy of Neurology 2012- Current American Epilepsy Society 2013- Current American Clinical Neurophysiology Society 2013- Current Texas Neurological Society

INVITED LECTURES

Date Site/Institution Topic/Title 9/9/2013 University of Tulane Regional Atrophy in Temporal Lobe Epilepsy 9/23/2013 University of Cincinnati Correlation of regional atrophy and cognitive impairment in temporal lobe epilepsy 2/29/2012 UT Southwestern Medical Correlation of regional atrophy and cognitive Center impairment in temporal lobe epilepsy 2/29/2012 UT Southwestern Medical Clinical pathology conference Center

RESEARCH SUPPORT (Grants, contracts, gifts)

Current Funding Darrell K Royal Foundation Research Award (Principal Investigator) 09/2015-08/2018 “Neurovascular Decoupling and Memory Impairment after Traumatic Brain Injury” Level of Funding: $150,000 overall

NIH/NINDS U01 NS086090 (Site Key Personnel) (Geoff Manley, MD (UCSF)) 09/01/13 – 08/30/18 “Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI)” Level of Funding: $19,000,000 overall, 0.4% effort

Previous Funding Texas Institute for Brain Injury and Repair pilot study (co-PI) 05/2015-04/2016 “Clinical and Neuroplastic Effects of Aerobic Exercise in Traumatic Brain Injury” Level of Funding: $100,000, 5% effort

American Epilepsy Society Research Infrastructure Award (Sub-site PI) 01/01 2014 to Kan Ding, MD 4 ______

12/31/2014 “Critical Care EEG Monitoring Research Consortium Database” Level of Funding: $2,000

BIBLIOGRAPHY 1. Wang SW, Kim BS, Ding K, Wang H, Sun D, et al. Requirement for math5 in the development of retinal ganglion cells. Genes & development. 2001; 15(1):24-9. 2. Yang Z, Ding K, Pan L, Deng M, Gan L. Math5 determines the competence state of retinal ganglion cell progenitors. Developmental biology. 2003; 264(1):240-54. 3. Scortegagna M, Ding K, Oktay Y, Gaur A, Thurmond F, et al. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nature genetics. 2003; 35(4):331-40. 4. Ding K, Scortegagna M, Seaman R, Birch DG, Garcia JA. Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha. Investigative ophthalmology & visual science. 2005; 46(3):1010-6. 5. Scortegagna M, Ding K, Zhang Q, Oktay Y, Bennett MJ, et al. HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood. 2005; 105(8):3133-40. 6. Oktay Y, Dioum E, Matsuzaki S, Ding K, Yan LJ, et al. Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. The Journal of biological chemistry. 2007; 282(16):11750-6. 7. Wang JY, Bakhadirov K, Devous MD Sr, Abdi H, McColl R, Moore C, Marquez de la Plata CD, Ding K, et al. Diffusion tensor tractography of traumatic diffuse axonal injury. Archives of neurology. 2008;65(5):619-26. 8. Dioum EM, Clarke SL, Ding K, Repa JJ, Garcia JA. HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery. Investigative ophthalmology & visual science. 2008; 49(6):2714-20. 9. Ding K, Marquez de la Plata C, Wang JY, Mumphrey M, Moore C, et al. Cerebral atrophy after traumatic white matter injury: correlation with acute neuroimaging and outcome. Journal of neurotrauma. 2008; 25(12):1433-40. 10. Ding K, Gong Y, Gupta P, Frol, A, McColl R, Agostini M, Modur P, Van Ness P, Diaz- Arrastia R. Regional Atrophy in Temporal Lobe Epilepsy: Correlations with Cognitive Impairment J Neurol Disord Stroke 2014 2(3): 1053 11. Gupta PK, Sayed N, Ding K, Agostini MA, Van Ness PC, et al. Subtypes of post-traumatic epilepsy: clinical, electrophysiological, and imaging features. Journal of neurotrauma. 2014; 31(16):1439-43. 12. Dubey D, Samudra N, Gupta P, Agostini M, Ding K, et al. Retrospective case series of the clinical features, management and outcomes of patients with autoimmune epilepsy. . 2015; 29:143-7. 13. Lee JW, LaRoche S, Choi H, Rodriguez Ruiz AA, Fertig E, et al. Development and validation of a critical care EEG monitoring database for standardized clinical reporting and multicenter collaborative research. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 2015 14. Ding K, Gong Y, Modur PN, Diaz-Arrastia R, Agostini M, et al. Temporal lobe volume predicts Wada memory test performance in patients with mesial temporal sclerosis. Epilepsy research. 2016; 120:25-30. Kan Ding, MD 5 ______

15. Chen H, Modur PN, Barot N, Van Ness PC, Agostini MA, Ding K et al. Predictors of Postoperative Seizure Recurrence: A Longitudinal Study of Temporal and Extratemporal Resections. Epilepsy Res Treat. 2016;2016:7982494. PubMed PMID: 27069682; PubMed Central PMCID: PMC4812270. 16. Lee JW, LaRoche S, Choi H, Rodriguez Ruiz AA, Fertig E, Ding K et al. Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. J Clin Neurophysiol. 2016 Apr;33(2):133-40. PubMed PMID: 26943901; NIHMSID: NIHMS786118; PubMed Central PMCID: PMC4878836. 17. Dubey D, Alqallaf A, Hays R, Freeman M, Chen K, Ding K et al. Neurological Autoantibody Prevalence in Epilepsy of Unknown Etiology. JAMA Neurol. 2017 Feb 6;PubMed PMID: 28166327. 18. Xing CY, Tarumi T, Meijers RL, Turner M, Repshas J, Ding K et al. Arterial Pressure, Heart Rate, and Cerebral Hemodynamics Across the Adult Life Span. Hypertension. 2017 Feb 13;PubMed PMID: 28193707.

Invited Reviews and Chapters

1. Review of intraoperative neurophysiologic monitoring, 3rd ed. JAMA Neurol 2013; 70(7): 943-944. 2. Intraoperative neurophysiologic monitoring. JAMA Neurol. 2013; 70(6): 803-804. 3. Review of Women with Epilepsy: A Practical Management Handbook JAMA Neurol. 2015:

Book Chapters 1. Ding K, Gupta PK, Diaz-Arrastia R, 2016 Epilepsy after Traumatic Brain Injury in Lastowitz D, Grant G (Eds), Translational Research in Traumatic Brain Injury, Boca Raton (FL): CRC Press/Taylor and Francis Group; 2016. Chapter 14. 2. Ding K, Diaz-Arrastia R, Posttraumatic in Felise S. Zollman (Eds), Management of Traumatic Brain Injury: Current Concepts and Clinical Applications, Second Edition, DemosMedical, Submitted

Abstracts

1. 69th American Academy of Neurology Annual Meeting, Boston, MA, April 2017 “Dynamic interaction between EEG and ICP: a pilot study based on wavelet coherence” Senior author 2. 69th American Academy of Neurology Annual Meeting, Boston, MA, April 2017 “Neurological Autoantibody Prevalence in Epilepsy of Unknown Etiology – APE Study” Co-author 3. 68th Annual Meeting of the American Epilepsy Society, Seattle WA, Dec, 2014 “Rhythmic Ictal Nonclonic Extremity (RINCE) Movements in Temporal Lobe Epilepsy: A Reappraisal” 4. 67th Annual Meeting of the American Epilepsy Society, Washington DC, Dec, 2013 “Discordance between Functional Magnetic Resonance Imaging (fMRI) and Wada test Kan Ding, MD 6 ______

for Language Lateralization” 5. 66th Annual Meeting of the American Epilepsy Society, San Diego, CA, Dce 3, 2012 “Relationship between Wada Memory Lateralization and Temporal Lobe Volume” 6. Grand Rounds, Department of Neurology, UT Southwestern Medical Center, Dalals, TX, Feb 29, 2012 7. 65th Annual Meeting of the American Epilepsy Society, Baltimore, MD, Dec 3, 2011 “Regional Atrophy in Temporal Lobe Epilepsy: Correlation with Cognitive Impairment” 8. 63rd Annual Meeting of the American Academy of Neurology, Honolulu, Hawaii, April 14, 2011 “Regional Cerebral Atrophy in Non-lesional Temporal Lobe Epilepsy: Correlation with Cognitive Impairment” (Platform presentation) 9. 33rd Annual Carrell-Krusen Neuromuscular Symposium, Dallas, TX, Feb 17, 2011 “Experience with cardiac transplantation in muscular dystrophy patients” 10. 60th Annual Meeting of the American Academy of Neurology, Chicago, IL, April 16, 2008 “Cerebral Atrophy after Traumatic Axonal Injury: Correlation with Acute Neuroimaging and Functional Outcome” (Platform presentation) 11. Keystone hypoxia meeting 2006, Jan 2006, Breckenridge, CO “Impaired myocardial energetics and altered intermediary metabolism in mice lacking the stress-responsive transcription factor Hypoxia Inducible Factor 2 alpha (HIF-2ɑ)” 12. American heart association scientific sessions 2005, Nov 2005, Dallas, TX “Master transcriptional regulators of vascular development” 13. 4th International symposium on organogenesis molecular control of neuronal organogenesis, Oct 2001, Ann Arbor, MI “Brn3b regulatory pathway in the development of retinal ganglion cells”