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Bioworld Technology CO., Ltd.

RFC2 (T165) Peptide Cat No.: BS9272P

Background Blocking Replication factor C (RFC) is an essential DNA polymerase ac- Specificity cessory protein that is required for numerous aspects of DNA This peptide can be used with studies using BS9272 RFC2 metabolism, including DNA replication, DNA repair and telo- (T165) pAb. mere metabolism. RFC is a heteropentameric complex that rec- ognizes a primer on a template DNA, binds to a primer terminus Purification & Purity and loads proliferating cell nuclear antigen (PCNA) onto DNA Synthetic peptide RFC2 (T165). (Note: the amino acid sequence at primer-template junctions in an ATP-dependent reaction. All is proprietary). The purity is > 98%. five of the RFC subunits share a set of related sequences (RFC Product boxes) that include nucleotidebinding consensus sequences. 1 mg/ml in DI water. Four of the five RFC genes (RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, Storage & Stability RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas Store at 4°C short term. Aliquot and store at -20°C long term. the RFC1 subunit does not. RFC2, the third-largest subunit of Avoid freeze-thaw cycles. the RFC complex, exhibits ATP binding which makes it im- Research Use portant for both DNA replication and checkpoint function. For research use only, not for use in diagnostic procedure. Swiss-Prot P35250 Applications

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