DESCRIPTION
This report displays different visual representations of the significantly enriched pathways for your input genes based on Reactome.
Namely, barplot, dotplot, cnetplot, upsetplot, heatplot, emapplot and pmcplot are generated.
Note that only those genes that map to the pathways database are used in the analysis.
Please refer to the ReactomePA and enrichplot packages for the explanation of the output plots.
For further details on this pipeline, please see the Pipeline Documentation. Enriched Pathways (Barplot)
M Phase
Estrogen−dependent gene expression
Mitotic Prophase
RNA Polymerase I Promoter Opening p.adjust
4.0e−06
8.0e−06
1.2e−05 Protein ubiquitination
DNA methylation
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Mitotic Anaphase
0 10 20 30 40 Enriched Pathways (Dotplot)
M Phase
Mitotic Anaphase
Mitotic Metaphase and Anaphase
Estrogen−dependent gene expression
p.adjust
4.0e−06 Mitotic Prophase 8.0e−06
1.2e−05
Protein ubiquitination Count
20
30
RNA Polymerase I Promoter Opening
DNA methylation
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
SIRT1 negatively regulates rRNA expression
0.050 0.075 0.100 0.125 0.150 GeneRatio Enriched Pathways (Cnetplot)
USP9XUSP9X UBE2KUBE2K
PRKDCPRKDC
UBE2G1UBE2G1
ProteinProtein ubiquitinationubiquitination TMEM129TMEM129 CDC20CDC20 LMNB1LMNB1 CDC27CDC27 CEP70CEP70 CDC27CDC27 NUP98NUP98
CLIP1CLIP1 H2BC5H2BC5 CLIP1CLIP1 TMPOTMPO
H2BC13H2BC13 size H2BC9H2BC9 CKAP5CKAP5 H2BC9H2BC9 20 ALMS1ALMS1 H2BC3H2BC3 H2BC3H2BC3 30
TAOK1TAOK1 VRK2VRK2VRK2 MitoticMitotic ProphaseProphase H2BC17H2BC17 NEK2NEK2NEK2 H2BC12H2BC12
XPO1XPO1 H2BC14H2BC14 RNARNA PolymerasePolymerase II PromoterPromoter OpeningOpening MM PhasePhase DYNC1LI1DYNC1LI1 NRIP1NRIP1NRIP1 H3C4H3C4 CNTRLCNTRL Estrogen−dependentEstrogen−dependent genegene expressionexpression H3C10H3C10 EML4EML4 ZW10ZW10 NUP155NUP155 KPNA2KPNA2 H3C3H3C3 H4C8H4C8 KIF20AKIF20A TNPO1TNPO1 ANAPC16ANAPC16 STAG1STAG1STAG1 HSP90AA1HSP90AA1 PTGES3PTGES3 SPASTSPAST
PDS5APDS5A KPNB1KPNB1 LBRLBR KIF23KIF23 GTF2A1GTF2A1 Enriched Pathways (Upsetplot)
10
5
0
M Phase Mitotic Anaphase Mitotic Metaphase and Anaphase Estrogen−dependent gene expression Mitotic Prophase Protein ubiquitination Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 DNA methylation RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA expression Enriched Pathways (Heatplot)
Transcriptional regulation of granulopoiesis
Transcriptional regulation by small RNAs
SIRT1 negatively regulates rRNA expression
Senescence−Associated Secretory Phenotype (SASP)
RNA Polymerase I Promoter Opening
RHO GTPases activate PKNs
RHO GTPase Effectors
Reproduction
Protein ubiquitination
PRC2 methylates histones and DNA
M Phase
Mitotic Prophase
Mitotic Metaphase and Anaphase
Mitotic Anaphase
Meiotic recombination
Meiosis
HCMV Late Events
HCMV Early Events
Gene Silencing by RNA
Formation of the beta−catenin:TCF transactivating complex
Estrogen−dependent gene expression
ESR−mediated signaling
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
DNA methylation
DNA Damage/Telomere Stress Induced Senescence
Condensation of Prophase Chromosomes
Cell Cycle Checkpoints
B−WICH complex positively regulates rRNA expression
Amyloid fiber formation
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
CIT LBR H1−1 CLIP1 EML4 H3C3 H3C4 H4C8 KIF23 NEK2 ORC2 VRK2 XPO1 ZW10 ASF1A CEP70 FKBP5 H3C10 MCM6 NRIP1 SIAH1 SPAST STAG1 TAOK1 TMPO ALMS1 CDC20 CDC27 CKAP5 CNTRL H2BC3 H2BC5 H2BC9 KIF20A KPNA2 KPNB1 LMNB1 NUP98 PDS5A PRKDC RBBP8 ROCK2 TNPO1 UBE2K USP9X GTF2A1 H2BC12 H2BC13 H2BC14 H2BC17 NUP155 PPP1CB PTGES3 UBE2G1 ANAPC16 DYNC1LI1 TMEM129 HSP90AA1 Enriched Pathways (Emapplot)
ProteinProtein ubiquitinationubiquitination
DNADNA Damage/TelomereDamage/Telomere StressStress InducedInduced SenescenceSenescence MitoticMitotic AnaphaseAnaphase
MitoticMitotic ProphaseProphase
MeiosisMeiosis MeioticMeiotic recombinationrecombination CellCellCell CycleCycleCycle CheckpointsCheckpointsCheckpoints ReproductionReproduction
AmyloidAmyloid fiberfiber formationformation PRC2PRC2 methylatesmethylates histoneshistones andand DNADNA
p.adjust CondensationCondensation ofof ProphaseProphase ChromosomesChromosomes
ActivatedActivated PKN1PKN1 stimulatesstimulates transcriptiontranscription ofof ARAR (androgen(androgen receptor)receptor) regulatedregulated genesgenes KLK2KLK2 andand KLK3KLK3 2.5e−05
Senescence−AssociatedSenescence−Associated SecretorySecretory PhenotypePhenotype (SASP)(SASP) 5.0e−05 RNARNA PolymerasePolymerase II PromoterPromoter OpeningOpening HCMVHCMV EarlyEarly EventsEvents 7.5e−05 MitoticMitotic MetaphaseMetaphase andand AnaphaseAnaphase ERCC6ERCC6 (CSB)(CSB) andand EHMT2EHMT2 (G9a)(G9a) positivelypositively regulateregulate rRNArRNA expressionexpression MM PhasePhase size
20
B−WICHB−WICH complexcomplex positivelypositively regulatesregulates rRNArRNA expressionexpression 30 RHORHO GTPaseGTPase EffectorsEffectors RHORHO GTPasesGTPases activateactivate PKNsPKNs TranscriptionalTranscriptional regulationregulation ofof granulopoiesisgranulopoiesis TranscriptionalTranscriptional regulationregulation byby smallsmall RNAsRNAs
FormationFormation ofof thethe beta−catenin:TCFbeta−catenin:TCF transactivatingtransactivating complexcomplex
DNADNA methylationmethylation HCMVHCMV LateLate EventsEvents SIRT1SIRT1 negativelynegatively regulatesregulates rRNArRNA expressionexpression
GeneGeneGene SilencingSilencingSilencing bybyby RNARNARNA Estrogen−dependentEstrogen−dependent genegene expressionexpression
ESR−mediatedESR−mediated signalingsignaling Enriched Pathways (Pmcplot)
200000
150000
query
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 DNA methylation Estrogen−dependent gene expression Mitotic Anaphase Mitotic Metaphase and Anaphase Mitotic Prophase 100000 M Phase Number of articles Protein ubiquitination RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA expression
50000
0
2010.0 2012.5 2015.0 2017.5