Statistical modeling of biomedical corpora: mining the Caenorhabditis Genetic Center Bibliography for genes re- lated to life span

1 2 1,3 2 D.M. Blei∗ , K.M. Franks , M.I. Jordan∗ and I.S. Mian∗

1Computer Science Department, Princeton University, Princeton, New Jersey 08540 USA 2Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720-8265, USA 3Department of Statistics, University of California Berkeley, Berkeley, California 94720, USA

Email: D.M. Blei∗- [email protected]; M.I. Jordan∗- [email protected]; I.S. Mian - [email protected];

∗Corresponding author

1 Additional Files Additional File 1: bmc lda supplement.pdf

Results for each of the 50 latent topics specied by a 50-topic LDA model estimated from a corpus of 5,225

documents and a 28,971 word vocabulary. Each panel shows results for a particular topic. The y-axis of

the graph is topic-specic word probability (βkv) and words are arranged along the x-axis according to this likelihood. Only the 500 topic annotation words are plotted since the remaining words in the vocabulary

have negligible probabilities. The words displayed explicitly are unigrams in the CGC vocabulary and

include the names of C. elegans genes and GO terms. The position of a word along the x-axis represents its rank; the staggering of words along the y-axis is not signicant and is designed only to improve legibility.

Gene names in bold denote genes implicated in modifying life span and listed in Table 1 of the manuscript.

The graph legend lists two types of automatically-generated topic labels. CGC-based topic labels are a subset of the 50 500 topic annotation words that are unique to a topic and are words from the CGC × vocabulary; these labels are ordered according to decreasing βkv values. GO-based topic labels are the children and grandchildren GO terms of GO terms that are also topic annotation words. Only GO terms that occur four or more times are given and are listed in decreasing frequency (MF: molecular function;

CC: cellular component, BP: biological process). A CGC-based label is unique to a topic whereas a

GO-based label can be applied to one or more topic.

2 Topic: 0 membrane 0.050- mating myosin intracellular 0.045- behavior cytoskeleton 0.040- locomotion ovulation 0.035- cytoplasm development 0.030- fertilization

0.025- reproduction spe-6 spe-9 lim-7 spe-27 fer-4 psa-4 0.020- gon-1 sys-1 fer-7 him-5 psa-1 spe-5 spe-15 0.015- spe-4 gon-4 spe-13 spe-12 div-1 fer-2 lag-2 | | spe-8 srg-1 - fer-3 0.010 fer-1spe-11 spe-29 fer-15 | fem-1 tlp-1 | | | fer-6 msp-3 - | skn-1 0.005 | msp-142 | | | | | | | | ||| || | | | | | | | || | | ||| | | | | | || | || | | | | | | | | | || - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial outer membrane, mitochondrial membrane, peroxisomal mem- brane, cytoplasmic chromosome, intermediate lament cytoskeleton, apical part of cell, basal part of cell; BP: hexose mediated signaling, adult feeding behavior, ethylene mediated signaling pathway, osmosensory signaling pathway via two-component system, abscission, aging, carbohydrate mediated signaling, regula- tion of locomotion, adult behavior, two-component signal transduction system ’phosphorelay’ CGC-based labels: msp, spermatozoa, spermatid, pseudopod, motility, skn, fer1, crawling, ow, spermiogenesi, fertil- ized, spermatheca, spe11, spe, spermatocyte, amoeboid, gonadogenesi, competition, ovulation, spe8, spe12, spe4, proximal, gon1, spe27, crawl, spe6, membranou, spermspecic, spermathecal, fertilize, motile, leading, cytoskeletal, spe29, pseudopodial, mfs, fer2, gon4, mos, bzip, fer, monensin, mo, spe5, metalloprotease, sem- inal, sys1, fertilizationdefective, fer4, attached, fer6, foci, delayed, sessile, triethanolamine, spherical, edge, unfertilized, appearance, selertilization, uid, spermatozoan, competitiveness, spermatozoon, fer3, tlp1, rearward, precedence, lopodia, div, sealing

3 Topic: 1 growth

0.050- reproduction

0.045-

0.040- hormone digestion 0.035- excretion metabolism 0.030- cytochrome development

0.025-

0.020-

| 0.015-

0.010-

| | cad-1 0.005- sym-1 | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: abscission, aging, drug metabolism CGC-based labels: axenic, media, liver, aceti, chemically, turbatrix, supplement, nutritional, dougherty, axenically, supplemented, proteina- ceou, glycogen, glycerol, monoxenic, heme, chick, glucose, folic, nutrition, particulate, mitop, aminopterin, nigon, aqueou, redivivus, aphelenchu, radioactive, anaerobic, liter, rh, methionine, nitrogen, incubated, preliminary, uorodeoxyuridine, sym1, cultures, culturing, mineral, hemin, haemin, suspension, utilization, incorporation, sialic, easily, reared, pure, supported, degenerative, cbmm, haem, synchrony, histidine, di- gested, excretion, concluded, plate, evaluated, lg

4 Topic: 2 growth

0.050- mec-8

0.045-

0.040-

0.035-

0.030- chemotaxis betaglucuronidase 0.025- cdk-9 0.020- smu-2 ceh-17 fax-1 0.015- smu-1 ceh-6 unc-6 gon-2 spt-4 0.010- unc-86 ceh-18 spt-5 | aip-1 | 0.005- | | unc-52 | | | || | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: exodeoxyribonuclease; CC: ; BP: CGC-based labels: training, memory, image, longterm, humic, conditioning, retention, ceh18, pyrene, bioconcentration, hs, gon2, cold, measuring, three- dimensional, cr, dhp, gravity, doc, ceh6, thesauru, imaging, recorded, dissolved, smu1, fax1, machine, video, tefb, automatic, improve, precision, ltrate, fourdimensional, algorithm, pirouette, cecrmp, cooling, spt, simultaneously, optical, coecient, robot, crmp, piwi, grd, betaglucuronidase, concept, dimension, nonneu- ral, robust, statistical, spring, experiments, tube, gsc, hh, wrt, nom, ham, bap, bcf, retrieval, drift, digital, record, local, em, timelapse, sand, nonlinear, scanning, created, discrete, session, pit1, aceperl, ceh17, airap, vocabulary, benzo, simulated, nonspecic, intensity, wholemount, document, back, foraging, multiphoton, biologically, ground

5 Topic: 3

0.050- digestion growth 0.045- nucleosome

0.040- transport endonuclease transferase 0.035- cht1 transporter enzyme chromosome host 0.030- furin

0.025- transcription

0.020-

0.015- act-1 cdc-42 rac-1 0.010- asp-1 | ilp-1 | 0.005- | opt-3

| | | | | | | | | | | | | | | | | | | || | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: CGC-based labels: cdna, clone, northern, vector, primer, designated, yac, oligonucleotide, southern, lambda, amplied, rt, volvulu, phage, hybridize, chicken, interrupted, degen- erate, kex2, cerac1, p21, hybridized, subclone, transfected, articial, proteinase, endoprotease, ggt, introns, aspartic, hybridizing, nucleoside, cepak, oscillin, opt3, cdc42ce, lh, overlapping, representing, aqp, bip, smt3, middle, onchocerca, clones, segregator, pyrimidine, designed, nucleosome

6 Topic: 4 development

0.050-

0.045-

0.040- microtubule spectrin

0.035- membrane cytoplasm 0.030- gastrulation morphogenesis 0.025-

| exc-5 | unc-85 0.020- jam-1 pal-1 die-1 let-502 mab-19 0.015- him-5 vab-7 sma-1 lin-5 unc-70 unc-83 0.010- lin-26 lin-6 unc-84 lin-22 spc-1 anc-1 ncl-1 0.005- cdh-3 unc-59 || || | | | | | | | | | | | | | | | | | | | | | | | || | || | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial outer membrane, cytoplasmic chromosome, mitochondrial membrane, peroxisomal membrane; BP: ethylene mediated signaling pathway, osmosensory signaling path- way via two-component system, abscission, aging, two-component signal transduction system ’phosphorelay’ CGC-based labels: hypodermal, seam, excretory, epidermi, apical, adheren, epithelia, junctions, mor- phogenetic, dierentiate, autonomously, epithelium, hypodermis, primordium, syncytium, integrity, sulston, serial, lin5, canal, ectodermal, hyp7, speculate, dev, vab7, horvitz, autonomou, boundary, duct, surrounding, acquire

7 Topic: 5 flp-1

0.050- transporter 0.045- metabolism

0.040- cytochrome biosynthesis 0.035- development reproduction 0.030- digestion transport 0.025- flp-5 flp-16 spe-26 0.020- flp-18 flp-4 flp-10 flp-6 flp-15 glc 0.015- daz-1 sqv-7 flp-17 flp-3 flp-2 spe-10 0.010- flp-8 flp-12 afp-1 flp-13 | flp-14 goa-1 flp-9 flp-11 0.005- flp-7 | | | | | | | || | || || | | || | | | | | | | | | || | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: regulation of cholesterol absorption, cholesterol absorption, abscission, aging CGC-based labels: farp, p1, twodimensional, heparan, spot, glycosaminoglycan, fmrfamiderelated, fmrfamidelike, phe, spectrometry, immunoreactivity, p9, p13, chondroitin, arg, nh2, digestion, met, p3, p8, fb, strip, daz1, resolution, fmrfamide, p4, p6, microvilli, udp, glycosphingolipid, af2, p5, bodymem- branou, mated, p14, p7, af1, hedgehog, immunoreactive, antiserum, p12, af8, desorption, ksaymrfamide, p2, gerp95, achieved, conformational, silver, fmrf, daz, gasphase, timeoight, edman, hplc, subjected, peptides, ala, moiety, successful, accurate, sqv7, disaccharide, amide, p10, p11, p15, p16, p18, kheylr- famide, dehydroergosterol, pf1, pf3, mh, svpgvlrfamide, spermatogonial, carbonylated, sdpnrfamide, spec- trometer, phosphorylcholine, matrixassisted

8 Topic: 6 tra-1

0.050- chromosome her-1 0.045- tra-2 xol-1 0.040- fem-1

0.035- fem-2 development calpain 0.030- mating mab-3 0.025- dpy-27 mel-11 sex-1 lin-15 dao-6 dpy-26 him-8 mix-1 lin-28 dpy-22 her-2 dao-7 0.020- | sdc-3 dbl-1 egl-1 | mog-4 dao-3 | egl-41 egl-16 dpy-21sma-2 mog-6 cet-1 dao-1 | sdc-2 fox-1 dpy-23 sup-21 dao-2 - fem-3 lon-1 dao-9 0.015 sdc-1 lin-22 lin-32 | sma-3 mog-5 mog-3 uxt-2 tra-3 lin-14 uvt-4 fog-2 him-5 mab-9 dao-8 - | 0.010 || dpy-30 sup-7 | | mag-1 myo-1 || fog-1 fog-3 mab-11 | dpy-28 sma-4 myo-2 mab-1 | let-502 dpy-29 dao-4 | || mog-1 0.005- | mog-2 act-4 ||| him-1 dao-5 | ||| | | | | | | | | || | | | | | | || | | | | | | | | | | | | | || || | ||| || | | | || | | | ||| || | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: exodeoxyribonuclease; CC: ; BP: ethylene mediated signaling pathway, osmosensory signaling pathway via two-component system, two-component signal transduction system ’phosphorelay’, negative regulation of transcription by pheromones, positive regulation of transcription by pheromones, reg- ulation of transcription from pol i promoter mitotic, ethylene mediated signaling pathway ’induced systemic resistance’, ethylene mediated signaling pathway ’jasmonic acid/ethylene dependent systemic resistance’, mapkkk cascade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, pos- itive regulation of transcription from pol i promoter mitotic, thermoregulation, fat body metabolism ’sensu insecta’, fever, homoiothermy, negative regulation of transcription from pol ii promoter by pheromones, positive regulation of transcription from pol ii promoter by pheromones, abscission, aging, development of primary sexual characteristics, development of secondary sexual characteristics CGC-based labels: sex, tra1, dosage, her1, xx, compensation, sexual, xo, xol1, tra3, sdc1, fem, males, sdc2, dpy21, sdc3, dpy26, dpy27, sexe, mab3, dpy28, dpy30, hermaphrodites, fox1, sexspecic, dbl1, feminizing, fog, sexdetermination, copulatory, masculinization, sma, mel11, sexually, sdc, feminization, dimorphism, malespecic, hierarchy, masculinizing, mog5, transform, mog6, mog4, lf, dpy22, sex1, pp2c, mog2, sexes, mag1, mel, global, nu- merator, mog3, mndp8, stdp2, mndp10, dpy23, equalize, dsx, cet1, cpeb, coordinately, dimorphic, diploid, feminize, bmp, triploid, sexlinked, compensate, mix1, mndp9, mndp25, females, mndp27, bursa

9 Topic: 7 development

0.050-

0.045-

0.040-

0.035- aging 0.030- behavior

0.025-

| | 0.020-

0.015-

0.010-

| | 0.005- | | old-2

| - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: adult feeding behavior, abscission, aging, adult behavior, determina- tion of adult life span CGC-based labels: review, detailed, progress, provided, past, oer, focu, chapter, advance, area, systems, brenner, reviewed, example, physiology, opportunity, description, summarize, excel- lent, phenomena, dissection, genetics, numerou, mechanisms, attention, address, contribution, way, emerged, dicult, briey, interested, focused, challenge, volume, simplicity, investigator, sparc, sydney, kingdom, re- markable, invertebrates, highlight, elucidation, ideal

10 Topic: 8 chromatin 0.050- tubulin sporulation mes-3 nuclease 0.045- mes-2 cytoplasm pachytene nucleoplasm 0.040- mes-6 microtubule

- ligase 0.035 chromosomeubiquitin development 0.030- enzyme behavior

0.025- antibody apl-1 sup-29 glp-4 rad-4 spk-1 0.020- cec-1 rad-6 set-2 hda-7 him-4 ula-1 | sup-24 0.015- | ubc-1 | set-1 let-70 | him-5 ubc-12 him-8 feh-1 0.010- ubc-2 hbl-1 ned-8 |mes-4 fem-2 | | sup-28 || || him-7 | lin-59 || odc-1 - | tba-1 0.005 | | | | mes-1 | | | | | | | | | | | | || | | ||| | | | | | | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: axonemal microtubule; BP: abscission, aging, polyubiquitination, spermidine biosynthesis CGC-based labels: mes, sc, mes3, mes2, mes6, synaptonemal, mes4, sr, ubc, ubc2, polycomb, topoisomerase, tdna, emap, isotype, karyotype, ferm, scs, trp, drr, ubiquitinlike, knob, ubc1, him4, ned, ubiquitinconjugating, mttrna, colchicine, ubc4, univalent, anticodon, apl1, tba1, tertiary, him7, ligase, hbl1, trnapro, mbz, polyamine, condensation, betaamyloid, susceptible, odc, cca, feh1, lon, tu, set1, conjugating, ubc5, sup24, notion, ornithine, cesf2, odc1, cec1, set2, conjugation, ceatl1, sup29, dimethyl, proteasome, wt, mnt6, tyr, sup28, mebendazole, modifying, senescent, incidence, plaque, e2, ned8

11 Topic: 9 aging 0.050- age-1 cytochrome daf-2 transport 0.045- daf-16 behavior clk-1 antioxidant 0.040- catalase

0.035- telomere reproduction metabolism 0.030- development |

0.025- growth | akt-1 | sod-1 unc-64 spe-26 mev-3 daf-23 ctl-1 daf-9 0.020- daf-7 daf-4 sod-4 gro-1 cyt-1 eat-18 clk-2 old-1 sir-2 mrt-2 0.015- sod-3 unc-31 isp-1 | fer-15 zyg-9 | daf-18 eat-2 ldb-1 daf-12 rad-8 cat-5 pdk-1 sod-2 spe-10 0.010- mev-1 emb-27 clk-3 daf-28 age-2 ins-1 eat-6 || akt-2 tkr-1 - | | mev-2 0.005 | | spe-9 | | | | | || | | | | | | | | | | | | | | | | | | | | | | | | | | || || | | | | || | | | | | | || | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial derivative, kinetoplast, mitochondrial degradosome, micro- some, telomerase holoenzyme complex; BP: adult feeding behavior, determination of adult life span, abscis- sion, aging, drug metabolism, adult behavior CGC-based labels: age1, longevity, lifespan, clk1, ageing, insulin, mev1, insulinlike, longlived, daf18, superoxide, fer15, clk2, gro1, daf23, clk, akt1, dismutase, akt2, extended, consumption, clk3, pdk1, rad8, sod3, pten, old1, diapause, ctl1, aged, thermotolerance, caloric, igf, tkr1, gerontogene, daf28, agespecic, coq7, sod2, expectancy, ubiquinone, receptorlike, dramatically, carbonyl, sod, sir2, hx546, antioxidant, capacity, tension, paraquat, daf9, itt, lengthen, cln3, agedependent, pi3k, chronological, fashion, nondauer, postreproductive, ins1, replica, lived, slow, slowing, singlegene, age2, coenzyme, spe10

12 Topic: 10 collagen

0.050- development

0.045-

0.040-

0.035-

| 0.030- |

| morphogenesis | betagalactosidase 0.025- col-19 col-40 act-4 cpr-5 gly-1 col-6 pes-1 col-36 cpr-3 0.020- col-12 mtl-1 dpy-10 clb-1 cpr-6 dpy-7 wee-1 col-17 col-2 dpy-20 cpr-4 0.015- col-3 dpy-13 sqt-3 dpy-2 gly-15 sqt-1col-1 col-34 ubq-2 rol-6 col-8 emb-9 unc-76 0.010- col-7 lon-3 phy-3 myo-2 pdi-2 | col-14 clb-2 | let-2 ama-1 col-13 cpr-1 phy-1 col-35 0.005- | phas-1 gcp-1 | | | | | | | | | | | | ||| | | | | || | ||| | || | | | ||| | | | | | | | | ||| | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: abscission, aging, thermoregulation, fat body metabolism ’sensu in- secta’ CGC-based labels: larval, collagen, l1, stages, molt, col1, l4, l2, col2, col12, col6, adults, col13, dierentially, alpha2, col14, pkc1b, collagens, col7, correlate, col8, collagenou, shift, cpr1, adulthood, ex- oskeleton, moult, phy, clb2, lon3, col34, postdauer, survive, start, abundantly, wee1, clb1, col36, patterns, steadystate, twofold, l2d, phas1, col40, sqt, col, microinjection, hsp90, morphologically

13 Topic: 11 kinase

0.050phosphorylation- phosphatase 0.045-

0.040- mitosis 0.035- intracellular dephosphorylation 0.030- budding phospholipase 0.025- cul-1 xbp-1 his-13 ncc-1 his-14 0.020- evl-20 | unc-43 his-15 | ire-1 cki-2 his-11 ksr-2 his-16 0.015- cyd-1 let-502 | ser-2 | mek-1 stu-7 his-9 cdk-1 cki-1 bir-1 his-10 0.010- cam-1 cdk-4 cul-2 his-12 cdc-25 cdc-2 cks-1 cdk-7 glc-7 0.005- cdl-1 | pek-1 | | || | | ||| || | | | | | | | || | | | | | | | | | | | ||||| | | ||| | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: cytosolic phospholipase a2, secreted phospholipase a2, phospholipase d, phospho- lipase a1, phospholipase a2; CC: ; BP: protein amino acid dephosphorylation CGC-based labels: phos- phorylation, akt, progression, cam, threonine, jnk, phosphorylated, ksr, cdc25, cdk4, phc, cki1, cdk, camkii, mek1, cyd1, hcf, ire1, g1, acclimatization, kinases, phosphorylate, pkb, calmodulindependent, thr, kringle, bir, ctd, icp, birp, guanylate, phospholipase, ncc1, cul1, cdk7, cak, hbp, cyclindependent, cdc2, p38, hfem, cehcf, plm, incenp, c2, fn2, upr, cki, pld, plc1, dynamical, rhobinding, adaptive, pvn, ck2, polo, perk, cetie, piak, tumour, ror, unfolded, abolished, hand, expanded, csk1, polyq, cip, cak1, plk, plc2, xbp, kip, dephos- phorylation, cho, lumbar, vp16, cul2, cdc, elimination, autophosphorylation, bir1, iap, ksr2, hairpinbinding, stu7, ser5, gin, mpf, nld, replace, plc

14 Topic: 12 ges-1

0.050- kinesin development transport membrane 0.045- osm-3 carboxylesterase cilium 0.040- mating microtubule 0.035- axoneme dendrite dynein cytoplasm 0.030- behavior chemotaxis intracellular 0.025- pkd-2 mec-8 lov-1 che-14 dyf-8 hsp-16 daf-10 che-1 che-7 dyf-13 0.020- pha-4 unc-104 osm-10 cat-6 dyf-4 | osm-1 pkd-1 gus-1 che-2 che-10 dyf-11 him-4 0.015- osm-6 che-13 ttx-1 dyf-6 | kin-29 | daf-6 che-12 | dyf-12 | osm-5 tax-4 0.010- che-3 unc-116 dyf-1 dyf-9 mec-1 che-5 | che-11 unc-101 | | che-6 |||| daf-19 pho-1 0.005- || unc-23 | | daf-15 tax-2 | | | || || | || | | | | | | | | | | | || || | | | | | | | | | | | | | | | | | || | || | | | | | | | | || | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: axonemal microtubule, mitochondrial outer membrane, mitochondrial mem- brane, peroxisomal membrane, apical part of cell, basal part of cell; BP: immune cell chemotaxis, adult feeding behavior, ethylene mediated signaling pathway, osmosensory signaling pathway via two-component system, adult behavior, two-component signal transduction system ’phosphorelay’, abscission, aging, neu- trophil chemotaxis CGC-based labels: ges1, cilia, kinesin, esterase, amphid, osm3, pha, osm5, che2, ash, osm1, retrograde, ending, avoidance, sensilla, amphidial, ciliated, lov1, gutspecic, pkd2, phasmid, ift, gesl, dendrite, daf19, cargo, che, repellent, anterograde, ir, che11, unc116, che13, avoid, intraagellar, wgatar, che10, cephalic, osm10, crystallin, che1, moving, cilium, che14, digestive, isoelectric, carboxylesterase, pho1, chaperonelike, cog, focusing, ciliary, rectum, tagged, deleted, dyf1, con, dendritic, che12, ase, perception, sorting, uorescein, repellents, raft, polycystic, lip, dendrites, tc, pkd1, adl, chemoreception, deirid, agella, dimeric, chemotaxis

15 Topic: 13 binding 0.050- development polyubiquitin 0.045- ras2

0.040- mep1 cytoskeleton 0.035- chaperone membraneintracellular atpase 0.030-

0.025- cytoplasm | |

0.020-

0.015- fli-1 crt-1 0.010- ubq-1 | | eft-1 0.005- | | eft-2

| | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: amino acid binding, calcium ion binding; CC: mitochondrial outer membrane, mitochondrial membrane, peroxisomal membrane, apical part of cell, basal part of cell; BP: CGC-based labels: motif, terminu, domains, hydrophobic, carboxyterminal, ef, aminoterminal, truncated, carboxyl, aminoacid, shared, pdz, acidic, proline, monomer, zipper, motifs, coiledcoil, atypical, terminus, forming, consisting, conventional, ao13, tm, interestingly, enriched, samdc, linker, presumed

16 Topic: 14 chromosome pachytene 0.050- microtubule budding | | mitosis spindle cohesin 0.045- chromatid centrosome condensin telomere mei-1 katanin 0.040- centromere midbody meiosis 0.035- cytokinesis antibody cytoplasm tubulin behavior centriole 0.030- kinetochore chromatin diakinesis dynein 0.025- chiasma cyk-1 hcp-3 zen-4 hcp-1 him-6 mre-11 cyk-3 0.020- hcp-2 air-2 air-1 cyk-4 | plk-1 | | him-14 spo-11 rec-8 | cds-1 0.015- mei-2 chk-2 dli-1 mel-26 unc-1 him-10 zyg-11 ptl-1 zyg-8 - msh-5 hif-1 0.010 | him-3 dnc-2 | lin-5 rec-1 rad-51 zyg-1 emb-27 | him-1 zyg-9 emb-30 him-8 0.005- | | dpy-3 | | | dhc-1 | | | | | | | | | || | | | | | | | | || | | | | | | | | | | || | | | | | | | | | | | | | | | | | | || | || | | | ||| | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial derivative, axonemal microtubule, centriole, telomerase holoen- zyme complex, dynein; BP: adult feeding behavior, female meiosis i spindle assembly, female meiosis ii spin- dle assembly, meiotic spindle assembly, adult behavior CGC-based labels: air, mei1, cytokinesi, prophase, metaphase, kinetochore, furrow, anaphase, cytokinesis, centromere, aurora, crossover, chromatid, rec1, msh5, mel26, microtubules, mei2, zen, mitosis, him14, hcp, cyk, cohesion, air2, him6, cyk1, rad51, centrosomal, szt1, aster, him3, zyg, mei, holocentric, zyg11, midzone, chk2, mnt12, spo11, air1, synapsi, interphase, seg- regate, rec, mre11, breakage, zen4, mix, tau, pronuclear, chiasmata, hin1, depleted, crosslink, homozygote, promoting, poles, recombine, inversion, pronuclei, hif1, katanin, gammatubulin, dispensable, microtubuleas- sociated

17 Topic: 15 development

0.050-

0.045-

0.040-

0.035- reproduction 0.030- locomotion behavior 0.025-

0.020-

0.015- lin-17 0.010- | unc-33 | mab-5 unc-86 0.005-

| | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: adult feeding behavior, abscission, aging, adult behavior, regula- tion of locomotion CGC-based labels: ab, dom, abp, founder, aba, sediment, reproducible, p2, aquatic, microbeam, invariance, symmetrical, anatomical, tracking, inuenced, cellautonomou, typical, chosen, as- sessing, interpretation, nongonadal, born, p1, refractory, considered, earthworm, cdcl2, reproducibility, qual- ity, bilaterally, dictated, summary, extra, clay, nanu, regulative, morgan, determinate, observing, replaced, traced, strictly, petri

18 Topic: 16

0.050- cytochrome helicase 0.045- lysosome isomerase 0.040- endocytosis membrane 0.035- budding transport 0.030- gtpase endosome

0.025- chaperone cav-2 0.020- ehs-1 cab-1

0.015- cav-1 rme-2 cyp-3 0.010- rme-1 cup-5 lrp-1 dyn-1 rme-8 - | 0.005 | | | cyp-2 | | | | | | | | | | | | | | | | | | | | | | | | | | | || | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial outer membrane, mitochondrial membrane, peroxisomal mem- brane; BP: CGC-based labels: alignment, pombe, endocytosi, arabidopsi, recycling, rme, endocytic, orthologou, thaliana, tracking, globin, schizosaccharomyce, gef, dyn1, dynamin, homo, rab, cyp, bag, cave- olin, www, prokaryotic, tree, pfam, cup5, man, mmp, ra, gdp, diversication, http, assignment, sapien, phylogenetically, matche, cav, chemoreceptor, hidden, searche, frequent, searching, survey, gain, tpi, endo- cytosis, sponge, rme1, ssion, unicellular, prokaryote, hmm, tm4sf, auxilin, rap1a, fatp, glo, lcfa, edu, cyp3, uptake, lysosome, hsc70, classication, ytubulin, pleckstrin, distant, rhoa, adaptin, cerhogdi, fkbp, vgs, p450, lmp, cerhoa, eh, receptormediated, eps15, ubiquitou, orthology, orthologs, markov, proteincoding, analyze, criteria

19 Topic: 17

0.050-

0.045-

0.040-

0.035-

0.030-

0.025- kpc-4 let-354 sup-33 sup-34 0.020- sup-21 mel-23 sup-11 rol-8 lin-8 mel-26 0.015- sup-9 sup-22 sup-10 sup-39 lin-17 unc-52 sup-38 sup-23 0.010- sup-5 stu-9 unc-93 smg-2 mel-25 sup-7 dpy-17 let-323 0.005- sup-18 mel-24 | let-324 | | | | | | | || | | | | | | || | | || | | | || - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: CGC-based labels: dominant, suppress, mutations, severe, sup7, unc93, alter, dumpy, phenotypes, sup5, alleles, hypomorphic, extragenic, semidominant, penetrant, sup10, independently, restore, allelic, causing, remaining, allelespecic, disrupted, sup9, impaired, penetrance, con- ditional, mild, severity, products, sup11, pleiotropic, displayed, incompletely, incomplete, st5, nonessential

20 Topic: 18 skn-1

0.050- par-3 fertilization 0.045- pseudocleavage catenin 0.040- cytoplasm

0.035- centrosome cytoskeleton developmentspindle 0.030-

0.025- lin-44 mom-4 hmp-2 vab-3 par-6 nmy-2 hmr-1 emb-27 ama-1 lin-17 par-5 pos-1 pod-2 zyg-8 0.020- mlc-4 sgg-1 par-4 glp-1 dlg-1 end-3 ceh-13 mex-1 pkc-3 mom-1 zyg-9 med-1 pop-1 mex-6 spn-4 gpb-1 - pie-1 lit-1 mex-3 end-1 ncc-1 0.015 mom-3 nop-1 par-1 mom-2 bar-1 egl-20 vab-7 egl-27 ooc-3 ooc-5 spn-1 par-2 wrm-1 apx-1 let-413 spd-2 hch-1 0.010- apr-1 mes-1 mex-5 gsk-3 ajm-1 || | pod-1 spe-11 | ||| hmp-1 gex-3 | pal-1 mom-5 cib-1 src-1 | let-99 || cdc-42 ham-1 0.005- | | pry-1 gex-2 | | | | | | | | | | | || | | | || | | | ||| | | | || | | | | | | | || | | || | | | | | | | | | | | | | | | | || | ||| | | | | || | ||| - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: exodeoxyribonuclease, endodeoxyribonuclease, endoribonuclease, 5’-3’ exonucle- ase, purine-specic oxidized base lesion dna n-glycosylase, pyrimidine-specic oxidized base lesion dna n- glycosylase, pyrimidine dimer dna n-glycosylase, ap endonuclease; CC: intermediate lament cytoskeleton, centriole, cytoplasmic chromosome; BP: abscission, aging, cell wall modication during abscission, determi- nation of adult life span, adipocyte dierentiation, endothelial cell dierentiation, regulation of adipocyte dierentiation, regulation of endothelial cell dierentiation, regulation of locomotion, ethylene mediated signaling pathway, osmosensory signaling pathway via two-component system, locomotion, two-component signal transduction system ’phosphorelay’, occulation ’sensu saccharomyces’ CGC-based labels: polarity, par, par3, par2, par1, pie1, pop1, establishment, par4, par6, pop, asymmetrically, lin44, apr1, axe, wrm1, mom2, blastomeres, lit1, unequal, mex, establish, par5, mom4, mom5, polarization, betacatenin, onecell, rotation, establishing, cortex, segregated, mom1, mlc4, nmy2, partitioning, hmp2, cdc42, hmp1, mex5, ooc3, tcf, catenin, mex6, wrm, hmg, generating, dlg1, hmr1, bar, let99, pal, ql, pseudocleavage, pod1, responding, let413, twocell, apc, hmp, the, ooc5, lineagespecic, lit, mom3, cleavages, orient, periphery, polarize, gex, spn4, asymmetrical, end3, of, ooc, ajm

21 Topic: 19 transcription

0.050- development

0.045- homeostasis

0.040- nucleus gtpase | | growth 0.035- receptor binding 0.030- hormone

0.025- rps-5 lir-1 pes-10 taf-11 med-1 0.020- hlh-1 pal-1 nhr-2 hda-1 pha-4 hlh-2 hda-3 chr-3 gad-1 - gap-2 nhr-81 0.015 elt-3 egl-15 | nhr-23 nhr-82 | end-1 mls-1 elt-2 mtl-2 nhr-75 0.010- elt-1 mtl-1 ncl-1 elt-6 | lin-26 | elt-5 med-2 taf-10 lir-2 sur-5 0.005- | taf-5 | cbp-1 lin-32 | | | | || | | | | | | | | || | | | | | | | | | | | | | | | | | | | | | | ||| | || | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: amino acid binding, calcium ion binding; CC: ; BP: ethylene mediated signaling pathway, osmosensory signaling pathway via two-component system, two-component signal transduction sys- tem ’phosphorelay’, negative regulation of transcription by pheromones, positive regulation of transcription by pheromones, regulation of transcription from pol i promoter mitotic, ethylene mediated signaling path- way ’induced systemic resistance’, ethylene mediated signaling pathway ’jasmonic acid/ethylene dependent systemic resistance’, mapkkk cascade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, positive regulation of transcription from pol i promoter mitotic, negative regulation of transcription from pol ii promoter by pheromones, positive regulation of transcription from pol ii promoter by pheromones, negative regulation of transcription mitotic, regulation of transcription by pheromones, regulation of transcription mitotic, positive regulation of transcription mitotic, abscission, aging, negative regulation of transcription from pol ii promoter mitotic, negative regulation of transcription from pol iii promoter mitotic, positive regulation of transcription from pol ii promoter mitotic, positive regulation of transcription from pol iii promoter mitotic, activation of mapk ’osmolarity sensing’, activation of mapkk ’osmolarity sensing’, activation of mapkkk ’osmolarity sensing’ CGC-based labels: gata, nger, elt1, elt2, factors, elt, activator, end1, repressor, cbp, elt3, hnf, mesoderm, forkhead, chr3, fork, zincnger, p300, driven, deacetylase, heterodimer, transcriptionally, reductionounction, perform, cbp1, elt5, integrate, dn, taf, molecularly, ectoderm, inappropriate

22 |

Topic: 20 death 0.050- ced-3 nitrilase ced-4 cytosol 0.045- ced-9 nuclease ced-1 0.040- binding ced-5 cytochrome 0.035- caspase telomerase development enzyme 0.030- apoptosis phagocytosis | 0.025- homeostasis ces-1ced-8 ces-2 cps-6 0.020- | nuc-1 lin-33 | ced-7 mec-10 acy-1 0.015- ced-6 lin-24 ced-10 cep-1 lap-2 egl-1 dad-1 rac-2 0.010- ced-2 mec-4 mef-2 | deg-1 mec-6 | | | || | ced-12 | rac-1 0.005- || | | | | | | | | | | | | | | | | | | | | | | | | | | | || | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: cell death, abscission, aging CGC-based labels: death, ced, ced3, programmed, ced4, ced9, apoptosi, ced1, apoptotic, bcl2, ced5, caspase, ced2, ced10, engulfment, ced6, ced7, nuc1, corpse, ces2, ces1, apoptosis, pcd, celldeath, ced8, ice, dying, phagocytosi, suicide, ced12, cebnip3, fhit, bh3, transglutaminase, engulng, protect, p35, proapoptotic, dock180, cetwist, caspases, dad1, p53, e1b, csp, bcl, necrotic, telomerase, undergoing, interleukin1, killer, corpses, oligomerization, nit, convert- ing, pathological, deaths, protective, ice, injury, necrosi, counterpart, cep1, apaf1, prodomain, lta, mac, damageinduced, lin24, homeostasi, tunel

23 Topic: 21 mec-3

0.050- unc-86 mec-7 0.045- receptor

0.040-

0.035- microtubule behavior 0.030- locomotion

0.025- mec-5 mec-18 lin-32 egl-46 cgk-1 lrn-1 nmr-1 | eat-4 unc-37 unc-11 0.020- deg-1 mec-12 sem-4 mec-15 unc-24 mec-10 egl-44 elr-1 mec-2 cat-1 hab-1 0.015- | glr-1 mec-1 mec-17 cnd-1 tph-1 unc-4pag-3 mec-6 unc-55 egl-1 mec-4 unc-30 lin-11 unc-42 sra-6 0.010- | | avr-15 | mec-9 mec-8 unc-3 vab-15 mig-21 | | unc-25 unc-47 mec-14 ham-1 | | | | egl-5 0.005- | | | lrn-2 | | | | cat-2 | || | | | | | || | | | | | | | |||| | | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: exodeoxyribonuclease; CC: axonemal microtubule; BP: ethylene mediated signal- ing pathway, osmosensory signaling pathway via two-component system, two-component signal transduction system ’phosphorelay’, negative regulation of transcription by pheromones, positive regulation of transcrip- tion by pheromones, regulation of transcription from pol i promoter mitotic, ethylene mediated signaling pathway ’induced systemic resistance’, ethylene mediated signaling pathway ’jasmonic acid/ethylene depen- dent systemic resistance’, mapkkk cascade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, positive regulation of transcription from pol i promoter mitotic, negative regulation of transcription from pol ii promoter by pheromones, positive regulation of transcription from pol ii promoter by pheromones, regulation of transcription by pheromones, regulation of transcription mitotic, negative regulation of transcription mitotic, positive regulation of transcription mitotic, adult feeding behavior, as- partate transport, glutamate transport, negative regulation of transcription from pol ii promoter mitotic, negative regulation of transcription from pol iii promoter mitotic, positive regulation of transcription from pol ii promoter mitotic, positive regulation of transcription from pol iii promoter mitotic, activation of mapk ’osmolarity sensing’, activation of mapkk ’osmolarity sensing’, activation of mapkkk ’osmolarity sensing’, reg- ulation of locomotion, adult behavior, thermoregulation, fat body metabolism ’sensu insecta’, acidic amino acid transport, drug metabolism CGC-based labels: touch, mec3, mec7, mechanosensory, circuit, tap, pag3, glr1, mec2, gabaergic, mec12, eat4, lin32, mec5, mec9, connectivity, withdrawal, backward, dd, glr, protolament, locomotory, mechanosensation, reex, unc37, vd, egl46, vb, alm, unc55, circuitry, stimulu, mec17, mns, egl44, bdu, nonassociative, gentle, excitatory, mec15, mec18, lrn1, lrn2, nose, eg1, interstimulu, cgk, mec14, pvd, antagonistic, lineal, touchinsensitive, avd, alphatubulin, homeoprotein, electrical, pvm, mechanoreceptor, habituated, cnd1, dishabituation, chale, neurogenic

24 Topic: 22 enzyme

0.050- mab-5 defecation egl-5 peroxisome chemoattractant 0.045- catalase lin-39 pyrophosphatase ceh-13 peroxidase 0.040- metabolism | cholinesterase | digestion thioredoxin 0.035- midbody acetylcholinesterase glucosidase - phosphatase 0.030 hydrolase intracellular

| aldolase 0.025- ref-1 0.020- ceh-23 ceh-20 | ceh-15 0.015- lin-32 ceh-7 tax-1 egl-27 gpc-1 0.010- ceh-11 | pal-1 ceh-25 lin-22 | | tax-5 0.005- | | tax-3 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: phospholipase d; CC: apical part of cell, basal part of cell; BP: ethylene me- diated signaling pathway, osmosensory signaling pathway via two-component system, two-component sig- nal transduction system ’phosphorelay’ CGC-based labels: coa, dehydrogenase, nacl, ceh13, phosphate, hom, hydrolase, da, cathepsin, aminopeptidase, acetyltransferase, acetyl, wave, thiolase, chat, buer, ceh11, nudix, thioredoxin, tryptophan, scpx, adh, antennapedia, enzymes, enzymatic, peroxisome, adp, substrates, minute, co2, regional, ivd, v6, aldolase, tr, km, capping, carrier, pts2, glucosidase, se, selenocysteine, adapt, tetraphosphate, isozyme, oxidation, activities, ce2, isovaleryl, vial, selenoprotein, ketoacyl, posteriorspecic, triphosphatase, countercurrent, ic50, angstrom, hairy, ceh7, diadenosine, decrement, nad, starved

25 Topic: 23 unc-22

0.050-

0.045-

0.040- host 0.035- endonuclease binding 0.030- transposase chromosome

0.025- rte-1 unc-105 0.020- unc-33 dpy-5 unc-13 dpy-19 mut-4 0.015- nuc-1 gpa-2 prk-1 mut-5 ced-4 mdl-1 0.010- mut-2 dog-1 gpa-1 | mut-6 dpy-13 | rol-6 | unc-54 0.005- dpy-14 mxl-1 | | | | | | | | | | | | | | | | | | | | | | || | | | || - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: amino acid binding, calcium ion binding; CC: ; BP: hexose mediated signaling, carbohydrate mediated signaling CGC-based labels: tc1, transposon, transposable, excision, transposition, repetitive, tc3, inverted, transposase, elements, extrachromosomal, replication, mutator, tc4, ltr, mariner, tc5, footprint, tcb1, retrotransposon, circular, mut6, tagging, unstable, tca, tc2, groove, imprecise, anked, tc1a, ta, tc6, jump, sh, interspersed, mut5, tc7, tr679, hot, hin, tcl, mobile, preferred, transpose, mut4, foreign, horizontal

26 Topic: 24 receptor

0.050- mec-4 behavior 0.045- deg-1

0.040- transport transporter 0.035- locomotion intracellular | 0.030- defecation| membrane

0.025- egl-36 clh-1 goa-1 clh-4 egl-30 unc-68 gar-1 aex-2 egl-1 unc-74 clh-5 flr-2 0.020- deg-3 sup-40 cat-2 des-2 flr-4 lev-1 mec-6 lev-9 cap-1 flr-5 egl2- cat-1 flr-3 mec-10 unc-50 mod-1 ndg-4 0.015- flr-1 sup-20 clh-2 unc-38 npr-1 cap-2 enu-2 unc-105 unc-2 acr-3 egl-10 sup-41 bas-1 clh-6 ric-3 0.010- unc-29 acr-2 let-2 glr-1 unc-8 del-1 clh-3 sup-43 | ryr-1 crt-1 unc-22 || | egl-19 tph-1 lev-11 | cat-4 unc-49 lev-8 0.005- | itr-1 || unc-63 lev-10 nmr-1 | | || | | | || | | | | | | | | | || | | | | | | | | | | | | || | | | || | | | | | | | | | || | | | | | | | | | | | | | | | || || | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial outer membrane, mitochondrial derivative, mitochondrial membrane, peroxisomal membrane, apical part of cell, basal part of cell, microsome; BP: regulation of loco- motion, drug transport, eye pigment precursor transport, 2-keto-3-deoxygluconate transport, adult feeding behavior, negative regulation of locomotion, positive regulation of locomotion, adult behavior, locomotion CGC-based labels: serotonin, nicotinic, ht, degenerin, channels, nachr, unc8, levamisole, agonist, potas- sium, deg, enac, unc105, dopamine, rhythm, pharmacological, cation, deg3, gar, muscarinic, gated, antag- onist, egl36, subunits, ryanodine, acr, cic, clh, cat4, modulate, clc, gating, ryr1, acr2, r1, egl2, swelling, amiloridesensitive, nicotine, social, slo, clh1, electrophysiological, del1, nonalpha, conductance, alpha7, ce21, uoxetine, bas1, mechanically, acr3, voltage, sup20, ionotropic, coexpressed, insensitive, proteinlinked, ex- citability, des2, imipramine, cp, pharmacologically, voltagedependent, circadian, modulation, permeability, nmda, mod, reuptake, clh3, clh6, machr, excitation, npr1, unc50, lev9

27 Topic: 25 fem-3 0.050- development monooxygenase tra-2 membrane 0.045- gld-1 reproduction fog-1 0.040- meiosis telomere 0.035- enzyme cytoplasm 0.030- helicase gametogenesis binding 0.025- imprinting fem-2 her-1 glh-1 emo-1 rpc-1 pha-1 fog-2 glh-2 let-858 unc-125 0.020- | puf-7 fem-1 pos-1 act-1 glh-4 fog-3 cpb-1 mpk-1 | pgl-1 ncc-1 tra-3 | mog-1 glh-3 dpy-11 0.015- | nos-1 glp-3 pes-10 glp-1 vit-2 mex-3 glp-4 laf-1 mex-1 dpy-13 ama-1| cey-2 prg-1 - fbf-1 nos-3 0.010 rme-2 tra-1 | fbf-2 mes-1 prg-2 | him-8 | ama-2 | nos-2 mrt-2 smg-1 - | | him-3 0.005 | cgh-1 | | mag-1 | | || | | | | | | | | | | | | | | | | | | | | | | | | | || | || | | || || | | | | | || | | | | | | || | | |||| | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: amino acid binding, calcium ion binding, exodeoxyribonuclease; CC: cytoplasmic chromosome, telomerase holoenzyme complex; BP: regulation of calcium in er, female meiosis i spindle assembly, female meiosis ii spindle assembly, abscission, aging, er to golgi transport, intra-golgi transport, meiotic spindle assembly, microgametogenesis CGC-based labels: germ, gld1, ama1, glp4, pie, gld, fog3, oogenesis, tge, glh1, germlinespecic, mog, uq, fbf, nos2, fbf2, fbf1, gli, laf1, gametogenesi, nos1, dmq, granules, pgl1, alphaamanitin, nano, mx, pgc, amanitin, glh2, posttranscriptionally, star, dre, pumilio, emo1, mrt2, rpo, m118, qki, nos, deah, drf, pgl, nos3, progenitor, drp, mdf4, tges, puf, spermoocyte, b12, homocysteine, achieve

28 Topic: 26

0.050- ribosome cyclophilin 0.045- cytoplasm

0.040- antibody polyubiquitin 0.035- metabolism ribonucleoprotein 0.030- transcription ubiquitin

0.025- vit-2 rol-6 mai-1 act-2 smg-4 act-4 0.020- ubq-1 lin-15 smg-2 cyp-9 hlh-1 kin-10 smg-1 act-1 pdi-1 0.015- ife-3 unc-54 gpd-1 ife-1 mlc-1 vit-6 ife-2 gpd-3 gpd-4 tra-2 - uaf-1 0.010 gpd-2 smg-5 unc-52 uaf-2 act-3 mlc-2 smg-3 sup-39 dpy-5 | smg-7 cyp-13 0.005- | smg-6 rrs-1 | | | | | ||| | | | | | | | | || | | || | | | | | | | || | | | | || | | | | | | | || | | | | || | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: phosphatidylinositol 3-kinase class i; CC: ; BP: CGC-based labels: leader, spliced, splice, transsplicing, sl1, transspliced, sl2, premrna, sl, operon, smg, message, alternatively, poly- cistronic, tran, mlc2, acceptor, mrnas, gpd2, donor, cap, snrnp, ag, gpd3, transsplice, u2af, polyadenyla- tion, ife, surveillance, mlc1, stop, snrna, eif4e, smg2, smg4, nmd, transcripts, smg6, hairpin, operons, ubia, trimethylguanosine, uracil, smg3, premature, decay, remove, smg5, tbp, gpd4, gpd1, adar, n, monocistronic, ubq1, mai1, stemloop, sm, aauaaa, cetlf, smg7, myotactin, nucleotides, uaf1, uaf2, transcribe, oma, pkc1a, cstf, u1, acquired

29 Topic: 27 myosin | 0.050- unc-54 unc-22 0.045- unc-15

0.040- myofibril 0.035- atpase development 0.030- sarcomere antibody | 0.025- unc-82 let-59 lin-40 let-67 unc-95 act-3 let-426 unc-90 0.020- let-653 let-63 unc-60 peb-1 lev-11 sus-1 mlc-1 let-56 let-326 unc-52 tmy-1 spe-17 unc-78 0.015- myo-2 ges-1 unc-87 let-64 emb-29 | sup-3 act-2 let-336 let-61 dpy-20 0.010- myo-3unc-45 unc-89 let-60 let-347 | unc-23 act-1 let-52 let-65 | myo-1 act-4 unc-105 let-341 - | let-66 0.005 | | | unc-94 unc-97 | | | | | || | | | | | || | | | | | | | | | | | | || || | || | | | | || | || | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: myosin ii, unconventional myosin, striated muscle thin lament; BP: reg- ulation of locomotion, locomotion, negative regulation of locomotion, positive regulation of locomotion, microgametogenesis, abscission, aging CGC-based labels: myosin, thick, paramyosin, mhc, rod, unc45, l- aments, sup3, unc87, e675, tropomyosin, let56, act3, unc82, myo1, heavychain, unc89, sdf2, e190, peb, act2, sublament, musculature, chains, diameter, tmy1, lev11, assembled, mhca, let653, sdf9, lie, assemblage, nonunc54, lagenin, nestructure, um, globular, delete, lin40, tubule, organized, sdf8, myobrillar, posi- tioned, let52, sdf19, rigid, antimyosin, sdf7, waterston, hcdf1, backbone, structures, tubular, multilament, myosins, crossbridge, c183, reactivity, sdf10, immunological, edf1

30 Topic: 28 growth

0.050- reproduction

0.045-

0.040-

0.035- binding metabolism 0.030- hormone behavior 0.025-

0.020-

0.015- |

0.010- | |

0.005- | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: adult feeding behavior, adult behavior CGC-based labels: decreased, nematicidal, mushroom, ethanol, bacillu, treated, maximal, dauerlarvae, microgram, reversible, compost, threshold, thuringiensi, agaricu, pigment, microm, marked, mycelial, bisporu, pdk, paralysi, recover, de- creasing, concentrations, prevented, mug, prolonged, lipofuscin, dmso, temperatures, uorescen, cultivated, nms, centrophenoxine, amidantel, reached, sulfhydryl, fed, ecacy, nematicide, account, recovering

31 Topic: 29

0.050-

0.045-

0.040-

0.035- growth 0.030-

0.025- tol-1 0.020- fkh-2 dbl-1 lim-6 0.015- spe-9 ftt-2 0.010- pes-1 | glp-4 | tpa-1 ftt-1 gcy-7 0.005- | gcy-6

| | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: CGC-based labels: handedness, vary, hypothesi, t, tpa1, brood, duplicate, comparing, deleteriou, substantial, constraint, tness, aser, striking, redundancy, evident, experi- mentally, innate, asel, toll, million, faster, equal, hypothese, logistic, phyla, proportion, reproduce, equation, symmetry, architecture, exponential, immunity, tpa, complexity, frequently, belonging, populations, isogenic, ftt1, fewer, extent, weibull, sinistral, b3, speciation, ftt2, argue

32 Topic: 30 hsp-16

0.050-

0.045-

0.040-

0.035- intracellular chaperone 0.030- betagalactosidase growth

0.025- mtl-2 msh-6 rad-6 0.020- hsp-1 sod-1 mot-2 rad-5 rad-9 0.015- rad-7 rad-2 hsp-3 rad-3 | rad-1 hus-1 0.010- hsp-70 hsf-1 rad-4 nuc-1 | 0.005- | msh-2 glp-4 || | | | | | | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial derivative; BP: CGC-based labels: hsp16, heatshock, hsp70, rad1, cadmium, rad3, rad2, rad, inducible, hsp, microwave, rad7, surfactant, stressinducible, rad5, tolerance, exogenou, radiationsensitive, hypersensitive, endpoint, cd2, deposit, acute, stressor, sublethal, degreesc, fudr, fungicide, assessment, histochemical, heating, msh2, toxicological, pc72, enhancement, hsbp1, mancozeb, abeta, pluronic, magnetic, pb, zn, slightly, monitor, engineered, introduced, hypersensitivity, ed50, hsf1, ozonation, levels, irradiated, assess, monitoring, top3alpha, emf, nonimmobilizer, hsp70f

33 Topic: 31 rde-1

0.050- let-7

0.045-

0.040- growth receptor 0.035- helicase morphogenesis 0.030-development enzyme

0.025- lin-41 mex-3 mut-9 mut-2 ptp-3 dpy-18 nlp-2 vab-1 lir-1 pex-6 dhc-1 nlp-1 0.020- hlh-2 efn-3 dcr-1 plx-1 mut-6 ego-1 let-858 sax-1 ram-3 mab-7 efn-1 vab-3 rde-2 alg-2 let-502 ram-2 rrf-2 0.015- npc-1 lin-15 mab-21 alg-1 unc-119 ram-1 adm-1 ceh-32 pos-1 egl-3 rde-4 adt-1 ram-4 rrf-3 - ceh-43 pex-1 cfi-1 0.010 unc-22 vab-2 efn-2 rrf-1 mut-7 rde-3 lin-4 flt-1 mab-18 | ram-5 fem-1 mut-8 sqt-3 | | mab-20 smp-1 jam-1 0.005- | | kal-1 ida-1 him-8 | || | | | | | | | || | | | | | || | | | | | | | | | || | | | | | | | | | | | | | | | || | | | | | || | |||| || | | | | | | | | | || | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: 3’-5’ exodeoxyribonuclease, exodeoxyribonuclease; CC: mitochondrial derivative; BP: abscission, aging CGC-based labels: ray, silencing, dsrna, rde1, mut7, antisense, rde4, mab21, trigger, rde2, cosuppression, sirna, syndrome, dcr1, strna, mirna, vab1, rays, mab20, rde3, ceh43, rde, silenced, ceh32, semaphorin, triggered, ephrin, asm, alg1, alg2, efn, silence, let858, dicer, ram5, pex, kal, lgr, sequencespecic, eph, pex1, dcr, microrna, npc1, pex6, plx1, nep, ram, efn1, peroxin, humans, adamt, kal1, dopaminergic, interfering, systemic, pc2, nlp, ida, c11h1, sad, vab2, phogrin, adt1, remodeling

34 Topic: 32 |lin-12

0.050- glp-1 lin 0.045- | lag-2 receptor 0.040- development

0.035- sel-12 membrane

0.030- intracellular growth

0.025- gld-2 sog-1 fem-1 ego-5 egl-38 sup-17 dpy-3 sog-6 0.020- sel-11 sog-3 | sel-10 dpy-1 arg-1 aph-2 pen-2 sog-2 emb-5 sqt-1 sog-10 0.015- sel-1 ego-4 hop-1 sel-5 dpy-8 ego-2 | | spr-2 || dpy-10 spe-4 lag-1apx-1lin-11 cog-2 dpy-9 - | dpy-2 0.010 smg-1 sog-4 pal-1 sel-9 dpy-7 | ego-3 lin-17 aph-1 ego-1 0.005- | sog-5 | sel-8 | | | egl-29 | | | || | | | | | | | || | | | | | | | | | ||| | || | | | ||||| | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: phosphatidylinositol 3-kinase class i; CC: mitochondrial outer membrane, api- cal part of cell, basal part of cell, mitochondrial membrane, peroxisomal membrane; BP: hexose mediated signaling, carbohydrate mediated signaling, sucrose mediated signaling, abscisic acid mediated signaling, hexokinase-dependent signaling, hexokinase-independent signaling, regulation of abscisic acid mediated sig- naling, abscission, aging, occulation ’sensu saccharomyces’ CGC-based labels: notch, presenilin, lag2, glp, sel12, sel, uterine, lag1, lag, ac, hop1, alzheimer, sel1, vu, sel10, aph2, sup17, wastewater, nicastrin, gld2, apx, dsl, aph1, sel9, decisions, intrinsic, ank, reciprocal, cdc10, serrate, sel5, uterinevulval, cog2, initially, factorlike, familial, receiving, utse, sel11, aph, fad, hop, ppp, pen2, presumptive, aaa, extrinsic, choose, wwtp, oz112gf, discharge, uv1, presenilins, topology, su, kimble

35 Topic: 33

0.050-

0.045-

0.040-

0.035- behavior chaperone 0.030- membrane peroxidase 0.025-

0.020- ben-1 mut-2

0.015- syn-4 eff-1 pcm-1 0.010- cut-1 unc-22 cut-2 0.005- | || | || | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial outer membrane, mitochondrial membrane, peroxisomal mem- brane; BP: CGC-based labels: cut, crosslinking, mutagen, formaldehyde, eciently, cuticlin, damaged, enu, methyltransferase, mutagenic, aggregate, turnover, mutagenized, isoaspartyl, complexes, balanced, spectrum, tmp, prerequisite, aggregation, smhsp, cut2, polyglutamine, deletions, probability, pulsation, tocotrienol, monomeric, possibly, rearrangements, sulfonate, ls, trimethylpsoralen, iron, alphacrystallin, ve- locity, employed, threefold, uence, macromolecule, charged, processive, catalyzed, methanesulfonate, shsp, stock, crosslinked, true, oligomeric, radiationinduced, pcm1, dityrosine, frozen, retained, aberrant, accumu- lated, inviable, compete

36 Topic: 34 lin-14

0.050- lin-4 lin-29 0.045- lin-28 lin 0.040- prp21 | 0.035- development behavior chromosome 0.030- mating

| 0.025- cdf-1 mab-23 0.020- apm-1 unc-119 unc-101 unc-38 | col-19 0.015- lon-2 | dpy-5 daf-12 pha-1 lin-41 plg-1 0.010- dpy-1 | let-7 lin-42 | | lin-46 0.005- | lin-58 | | | | | | | | | || | | | | || | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial derivative; BP: adult feeding behavior, adult behavior, ab- scission, aging CGC-based labels: lin14, lin29, heterochronic, lin28, cross, polymorphism, trait, de, qtl, french, inbred, polymorphic, lin42, chez, la, snp, precociou, parent, traits, libre, downregulation, du, recombi- nantinbred, variance, inbreeding, maupa, lifehistory, f2, lines, rp, ovotesti, adultspecic, remodelling, apm1, heritability, renaturation, percent, interstrain, epistatic, les, rd, crosses, genetique, heterosi, zn2, selng, pleiotropy, threefactor, exceptional, dissected, hundred, nullo, highresolution, race, unrelated, clathrinasso- ciated, ark, heterochrony, cdf1, dds

37 Topic: 35 membrane 0.050- pha-1 vps34 receptor 0.045- pmr1 development 0.040- sarcomere vacuole locomotion 0.035- cytosol transport | myogenesis | atpase 0.030- intracellular growth

0.025- hemidesmosome mup-1 let-2 let-268 ceh-24 pat-10 mua-1 0.020- mup-2 nid-1 mua-3 eat-12 mup-4 unc-68 deb-1 0.015- pha-4 aex-1 let-512 myo-3 egl-19 unc-29 myo-2 exp-2 csq-1 ceh-22 mua-2 0.010- emb-9 eat-6 hlh-1 mua-5 pkc-2 bre-5 | | sca-1 || hlh-8 unc-52 0.005- | | | mua-6 | | | | | || | | | | | | | | | ||| | | | || || | | | | | | | | | | | | | | | | || | | | | | || | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial outer membrane, mitochondrial membrane, peroxisomal mem- brane, apical part of cell, basal part of cell, striated muscle thin lament; BP: ethylene mediated signal- ing pathway, osmosensory signaling pathway via two-component system, regulation of locomotion, two- component signal transduction system ’phosphorelay’, negative regulation of transcription by pheromones, positive regulation of transcription by pheromones, regulation of transcription from pol i promoter mitotic, negative regulation of locomotion, positive regulation of locomotion, ethylene mediated signaling pathway ’in- duced systemic resistance’, ethylene mediated signaling pathway ’jasmonic acid/ethylene dependent systemic resistance’, mapkkk cascade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, positive regulation of transcription from pol i promoter mitotic, abscission, aging, locomotion, neg- ative regulation of transcription from pol ii promoter by pheromones, positive regulation of transcription from pol ii promoter by pheromones CGC-based labels: basement, pha1, ceh22, troponin, myod, cemyod, m3, musclespecic, bt, subelement, ldh, myogenic, ceh, mup4, mup2, myogenesi, ceh24, mup1, nonstriated, calciumbinding, hlh8, membranes, lumen, pkc2, sphincter, exp2, coupling, bm, exp, nk, bulb, mua3, pat10, obliquely, store, calsequestrin, pmr1, voltagegated, let2, betaspectrin, coordination, resting, mup, sarcoplas- mic, serca, i5, mua, anal, excitable, cavity, organspecic, cardiac, elevation, tnt, rer, pump, nkx2, vps34, bre5, stable, hsp25, junctional, heart, marginal, csq1, ceslo2, csq, galbeta1, lysyl, isthmu

38 Topic: 36 antibody

0.050- lyase

0.045-

0.040- reproduction development growth 0.035- binding enzyme 0.030- metabolism

| | 0.025- srf-1 0.020- cut-1 srf-8 srf-9 0.015- srf-4 srf-5 lrp-1 0.010- dif-1 srf-3 srf-6 | | srf-2 fer-1 - | 0.005 | | gad-1 | || | | | | | | | | || | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: amino acid binding, calcium ion binding; CC: ; BP: drug metabolism, abscission, aging CGC-based labels: isocitrate, lyase, immunouorescence, lumbricoide, glh, glyoxylate, xation, srf2, srf3, malate, amine, antigenic, dif1, antisera, sitosterol, dehydrocholesterol, srf, visualized, dauerlarva, mount, ne, epicuticle, coat, srf5, western, take, peak, visualization, ferritin, dealkylation, srf4, densebody, cephalobu, propagated, campesterol, lrp, diminution, wga, itaconate, electrondense, thirdstage, lesser, rec- ognized, labelling, srf8, srf9, homogenate, enol, srf1, conguration, gad1, blue, metabolite, ly

39 Topic: 37 let-60

0.050- let-23 lin-3 0.045- lin-15 development 0.040- organogenesis lin nucleosome 0.035- lin-45growth isomerase kinasereceptor

0.030- mek-2 | - sem-5 0.025 sli-1 lin-38 lin-31 sur-5 mpk-2 lin-36 egl-17 efl-1 lin-40 egl-18 pvl-5 | lin-7 lin-11 sur-6 pvl-4 0.020- lin-8 bar-1 egr-1 lin-23 sqv-1 lin-2 tam-1 lin-52 lin-10 lin-25 gap-1 sem-4 lin-34 him-5 mom-3 ksr-1 dpl-1 fzr-1 lin-39 egl-15 hda-1 lin-18 rba-1 lin-33 0.015- lin-9 dig-1 lin-51 mpk-1| sur-2 egl-27 lin-24 | ptp-2 cye-1 lin-55 lin-1| sur-1 sur-8 ncl-1 sos-1 | lin-35 unc-101 sqv-8 chd-4 0.010- | let-341 lin-17 mig-14 lin-56 | | lin-37 phy-2 ||| lin-12 eor-2 chd-3 soc-2 || mab-5 lin-13 lin-26 | sqv-3 lin-54 | || | eor-1 clr-1 pvl-6 | | lin-53 pry-1 0.005- || | let-537 rok-1 | || || sqv-7 gon-10 | | | | | | | | | | | |||| | | || | ||||| | | | | || | | | | | | | | | | || | | | | || || | | | ||| | | | | | | || | | | | | || | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial derivative; BP: ethylene mediated signaling pathway, os- mosensory signaling pathway via two-component system, hexose mediated signaling, two-component signal transduction system ’phosphorelay’, carbohydrate mediated signaling, negative regulation of transcription by pheromones, positive regulation of transcription by pheromones, regulation of transcription from pol i promoter mitotic, ethylene mediated signaling pathway ’induced systemic resistance’, ethylene mediated sig- naling pathway ’jasmonic acid/ethylene dependent systemic resistance’, mapkkk cascade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, positive regulation of transcription from pol i promoter mitotic, sucrose mediated signaling, abscisic acid mediated signaling, hexokinase-dependent signaling, hexokinase-independent signaling, regulation of abscisic acid mediated signaling, negative regu- lation of transcription from pol ii promoter by pheromones, positive regulation of transcription from pol ii promoter by pheromones, regulation of fgf receptor signaling pathway, regulation of embryonic develop- ment rate, microgametogenesis, negative regulation of embryonic development rate, positive regulation of embryonic development rate, fgf receptor signaling pathway, abscission, aging, regulation of transcription by pheromones, regulation of transcription mitotic, drug metabolism, negative regulation of transcription mitotic, positive regulation of transcription mitotic, negative regulation of transcription from pol ii promoter mitotic, negative regulation of transcription from pol iii promoter mitotic, positive regulation of transcription from pol ii promoter mitotic, positive regulation of transcription from pol iii promoter mitotic, activation of mapk ’osmolarity sensing’, activation of mapkk ’osmolarity sensing’, activation of mapkkk ’osmolarity sensing’ CGC-based labels: vulval, ras, let60, lin3, lin15, lin45, lin1, mpk1, vpc, lin10, lin2, lin7, lin31, mek2, lin35, sur1, lin9, ksr1, lin25, multivulva, rasmediated, lin8, lin36, vulvaless, lin37, competence, sur2, gap1, synmuv, p8, basolateral, lin38, lin53, lin13, let341, sur8, equivalence, nurd, pas, hda1, cellsignaling, e2f, sur, p12, egr1, e1, eor1, eor2, redundantly, ptp2, dig1, muv, dpl1, mpk, tam1, invagination, graded, nonvulval, multipotent, antagonize, sur5, let537, sqv3, dp, phy2, competent, sqv8, cye1, lin18, antiallatal, lin34, ppi, hif

40 Topic: 38

0.050-

0.045-

0.040-

0.035-

0.030- transcription chromosome

0.025- ppp-1 uvt-1 0.020- msp-113 ceh-2 cdh-3 art-1 0.015- ceh-9 msp-71 crb-1 msp-74 ceh-1 msp-29 0.010- fkh-1 msp-56 hmr-1 msp-19 0.005- | | ceh-10 sod-1 | | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: CGC-based labels: multigene, cadherin, pseudogene, diverged, distantly, duplicated, existence, irp, intergenic, dlg, families, dispersed, ancestral, pairs, raise, sea, basepair, urchin, clustered, imply, members, interspecy, raising, remarkably, innexin, synapsin, connexin, arranged, metazoans, strikingly

41 Topic: 39 unc-13

0.050- cha-1 unc-17 0.045- unc-18 unc-64 0.040- mating unc-29 cholinesterase 0.035- development acetylcholinesterase 0.030- behavior locomotion rab-3 0.025- lon-2 unc-36unc-47 unc-42 unc-63 ace-1 unc-3unc-41 dpy-9 unc-20eat-6 lin-11 unc-65 him-8 bli-4 unc-43 unc-15 unc-23 unc-101 unc-44 cat-1 unc-34 dpy-20unc-30 him-5 egl-30ace-2 sad-1 eat-10 unc-70 0.020- unc-7 dpy-14 unc-78 lin-15 unc-40 emb-29 unc-26dpy-1unc-2 sma-2 sqt-3 sma-1 srl-1 eat-20 dpy-23 dpy-11 dpy-2 unc-38 egl-8 unc-79 act-2 eat-7 snt-1snb-1dpy-17 dpy-6unc-16 unc-5 ace-3 smg-1 sup-10 unc-11 unc-61 bli-2 unc-45 unc-58 mab-5 unc-27 0.015- | unc-4 unc-24 unc-1 lon-1 unc-37 let-2 rol-4 dpy-10 unc-54 dpy-13 goa-1 syd-2 unc-69 lin-1 unc-8 ric-2 unc-31rol-3unc-49 eat-2 rol-1 unc-76 eat-12 lev-10 unc-104 unc-75 sqt-1 lev-1 ric-4 daf-6 dgk-1 unc-77 eat-1 || rol-6 eat-18 srl-2 0.010- unc-25aex-3 egl-10 dpy-8 unc-35 unc-93 bli-3 lev-11 dpy-18| unc-59 unc-74 dpy-7 unc-52 dpy-5unc-32eat-5 unc-9 unc-33 unc-85 eat-11 | rpm-1 bli-5 dpy-4 osm-1 lin-26 unc-68 | unc-10 lin-10 unc-89 che-3 | unc-46 dpy-3 unc-60 || | unc-6 unc-50 bli-1 exp-1 0.005- || ||| unc-51 sma-3 unc-103 |||||| unc-57 sqt-2 act-1 | | | | || | | || | || | | || || | | ||| ||| | | | | | | | || | | | ||| | | || | || | | || ||| | | | || | | || | | | | || | || | | | | | | | | | ||| | || | | | | | | | | | | | | | | | || | | | || | | | | || |||| | || | | |||| | | | | | | | || | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: exodeoxyribonuclease; CC: mitochondrial derivative; BP: regulation of locomo- tion, ethylene mediated signaling pathway, osmosensory signaling pathway via two-component system, two- component signal transduction system ’phosphorelay’, locomotion, negative regulation of locomotion, pos- itive regulation of locomotion, negative regulation of transcription by pheromones, positive regulation of transcription by pheromones, regulation of transcription from pol i promoter mitotic, ethylene mediated sig- naling pathway ’induced systemic resistance’, ethylene mediated signaling pathway ’jasmonic acid/ethylene dependent systemic resistance’, mapkkk cascade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, positive regulation of transcription from pol i promoter mitotic, hexose me- diated signaling, aspartate transport, glutamate transport, adult feeding behavior, negative regulation of transcription from pol ii promoter by pheromones, positive regulation of transcription from pol ii promoter by pheromones, carbohydrate mediated signaling, drug transport, eye pigment precursor transport, 2-keto-3- deoxygluconate transport, acidic amino acid transport, adult behavior, abscission, aging, thermoregulation, fat body metabolism ’sensu insecta’ CGC-based labels: cha1, unc17, unc18, syntaxin, roller, dpy18, unc11, dpy11, unc36, rab3, snt1, unc26, aex3, rol3, snb1, ndf24, dpy1, unc41, lon2, unc46, eat5, dpy17, unc10, mndf30, unc59, unc75, ndf25, edf2, synaptobrevin, edf18, unc61, vesicles, snare, synaptotagmin, dpy14, mdf7, sdf35, mndf89, mndf1, exocytosi, rpm1, dpy6, edf3, mndf41, mndf88, dpy9, dpy3, ndf19, madf4, eat18, mndf68, ndf23, unc16, cover, unc23, edf6, bli5, rim, sdf28, aex, dpy8, syd2, sdf20, mndf4, bli2, aldicarb, unc20, ndf27, hdf9, ndf40, edf4, mc, srl2, e937, sdf6, rol1, synapses, priming, sma1, mndf61, qdf3, sdf26, noncomplementation, mndf111, dpy4, ardf1, superbu, ric4

42 Topic: 40 emb-5 0.050- cytoplasm intracellular 0.045- gtpase behavior 0.040- transport gastrulation 0.035- development chromosome 0.030- atpase ovulation

0.025- membrane gpb-2 nhr-25vha-2 let-389 let-756 let-377 let-382 let-530 let-502 let-504 emb-4 ric-8 klp-16 emr-1 let-2 let-392let-351 let-527 rgs-1 klp-3unc-32 gpa-3 kel-1 emb-30 let-376 let-381 let-391 let-514 let-505 0.020- zyg-3 ceh-38 emb-29let-610let-545 let-528let-356 gpb-1emb-13emb-8 emb-27 zyg-8 let-384 emb-19 lem-2 unc-37 vha-3 let-367 vha-5 let-603 zyg-10 let-544 let-529let-506let-366 mel-32emb-1emb-23 klp-17 emb-20 emb-11 let-380 acy-2 fkh-1 let-507 emb-31 lis-1 let-370 let-354 gpa-6 let-390 let-543let-394 0.015- sgs-1egl-10 emb-16 vha-11 bli-4 let-355 emb-28emb-35 lin-6 let-521 zyg-12 eat-16 emb-2 emb-25 let-388 lmn-1 let-513emb-22 unc-84let-396 gsa-1 unc-13 emb-21 gpa-2 emb-12 emb-15let-604let-353 let-522 gpa-8 emb-9 emb-3 nhr-2 emb-26 let-605 vha-6 let-400 let-534 let-721let-397 0.010- emb-7 vha-4 eat-11 let-395 let-606nud-1 let-385 let-523gpa-11 egl-30 emb-6 sag-1 vha-7 klp-12 zyg-7 let-520 let-532 let-725 let-398 goa-1 zyg-2 klp-15 vha-1 gpa-7 emb-14let-393 let-386 let-524gpa-15 zyg-1 gpa-1 atx-2 let-379emb-34 gpa-12emb-24 let-713 let-399 | dpy-5 zyg-9 emb-33 | dgk-1 emb-17 dpy-14 pad-1 let-387 let-525lem-3 0.005- | | | | emb-18 let-378emb-32 | | | let-383 let-531 let-512 let-503 || | | | || | || | |||| | | | | || || | | ||| || | | | | ||| | | | | | | || | | | | | | | | ||||||| || || | || || | | || | |||| |||||| ||||| | | || || | | | | | | | || ||| || ||||||| || | | ||| | | || | | |||||| | || || ||| | | | | | | | || | || ||||||||||||| |||| || | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: dynein, apical part of cell, basal part of cell; BP: ethylene mediated signaling pathway, osmosensory signaling pathway via two-component system, hexose mediated signaling, two-component signal transduction system ’phosphorelay’, carbohydrate mediated signaling, regulation of locomotion, negative regulation of transcription by pheromones, positive regulation of transcription by pheromones, regulation of transcription from pol i promoter mitotic, sucrose mediated signaling, abscisic acid mediated signaling, adult feeding behavior, ethylene mediated signaling pathway ’induced systemic resistance’, ethylene mediated signaling pathway ’jasmonic acid/ethylene dependent systemic resistance’, mapkkk cascade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, pos- itive regulation of transcription from pol i promoter mitotic, hexokinase-dependent signaling, hexokinase- independent signaling, regulation of abscisic acid mediated signaling, locomotion, abscission, aging, adult behavior, negative regulation of transcription from pol ii promoter by pheromones, positive regulation of transcription from pol ii promoter by pheromones, microgametogenesis CGC-based labels: rgs, envelope, akap, emb, ran, heterotrimeric, lamin, eat16, klp, goa, sgs1, mel32, gpb1, celamin, gpb, klp3, gpb2, gsa1, zyg2, emb7, nckx, permissive, proteolipid, emerin, pde, shmt, emb1, emb13, hdf6, nhr25, rii, tsp, emb3, emb6, man1, emb4, emb8, emb16, emb23, ceemerin, vha2, nonpermissive, dgk1, gpa1, adenylyl, sag1, nhr2, vha3, ggl, emb2, emb31, gpa3, ric8, strict, klp15, klp17, ima, hdp13, vha4, emb21, ataxin2, vha11, runt, temperatureshift, ri, sdf4, emb27, kel1, lis1, celam1, klp16, vacuolartype, atx2, vha, let367, nxf, let389, zyg3, vha7, mex67p, ntf2, ftz, emb18, emb25, emb26, emb33, brf, import, ncd, vha1, eat11, emb20, tethering, zyg8, let756

43 Topic: 41

0.050-

0.045-

0.040-

0.035- chromosome 0.030- transporter transport

0.025- dyc-1 0.020- sel-12 xnp-1 hlh-1 0.015- tcp-1 cat-1 0.010- dyb-1 dys-1 fgd-1 daf-21 vab-3 | 0.005- || cct-1 | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: ; BP: CGC-based labels: dys1, acedb, dystrophin, proteome, muscu- lar, mb, dystrophy, dystrobrevin, methods, providing, fgd1, dyb1, construction, comprehensive, completed, world, annotated, list, assigned, improved, full, obtaining, highthroughput, progressive, traditional, access, roundworm, disorder, scientist, smn, tfg, began, table, databases, practical, starting, outgroup, genomics, amenable, diseases, annotation, cambridge, microarray, glycopeptide, collection, explore, tcp1, chaperonin, duchenne, vacht, catalogue, genomewide, science, make, greatly, thousand, wealth, people, public, tcp, cpb, working, decade, medical, aid, spinal, success, john, technology, knockout, successfully

44 Topic: 42 galectin

0.050-

0.045-

0.040- oxidoreductase development 0.035- mating ribonucleoprotein 0.030- ribosome capsule 0.025- aps-2 unc-24 0.020- unc-7 rop-1 unc-80 0.015- unc-9 unc-1 gas-1 unc-124 0.010- | | unc-79 atp-2 nuo-1 - | | 0.005 | apm-2 | | | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial derivative, cytosolic ribosome ’sensu bacteria’, cytosolic ribo- some ’sensu eukarya’, cytosolic large ribosomal subunit ’sensu bacteria’, cytosolic large ribosomal subunit ’sensu eukarya’; BP: CGC-based labels: anesthetic, halothane, lectin, galectin, rrna, pacicu, pristionchu, character, ro, unc79, gas1, isourane, remanei, anesthetics, mtdna, genu, buccal, rdna, unc80, oscheiu, au- thor, ro60, rop1, rhabditida, capsule, punctata, stomatin, enurane, stereoisomer, cew1, diplenteron, rnp, pacicus, phylogeny, taxa, cephalobina, caenorhabditis, vas, secernentea, anesthesia, vulgari, panagrolaimu, rhabditina, distance, potency, framework, dolichorhabditi, halicti, betagalactosidebinding, ncl, distinguished, immobility, clinical, diplogastridae, rornp, rop, mtsrrna, taxon, postcorpu, osche, mt1, aps2, oesophageal, mrc, distinguish, resolve, ribosome, inferred, pelodera, apm2, proved, consideration, carbohydratebinding

45 Topic: 43

0.050-

0.045-

0.040-

0.035- digestion 0.030- host cytochrome 0.025- hsp-3 epi-1 0.020- vit-6 cam-1 mig-13 egl-41 rho-1 0.015- cal-1 egl-5 cam-2 his-24 hum-3 0.010- ham-2 hum-2 egl-43 mig-10 hum-1 0.005- egl-18 | | | | | | | | | | | | | | | | | || | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: parasitophorous vacuolar membrane, parasitophorous vacuole, host cell plasma membrane; BP: CGC-based labels: h1, usage, h2b, bia, h2a, sds, polyacrylamide, diet, h4, mig10, mig, electrophoresis, isoenzyme, calf, ltration, electrophoretic, synonymou, gonaddependent, nonhistone, synthetase, dodecyl, optimal, lysine, yp88, yp115, urea, sulphate, biase, alanine, bulin1, tes, egl43, fraction- ation, extraction, dalton, main, resolved, ham2, thymu, silent, cb, doublet, covalent, biased, polypeptides, extracted, can, yp170a, estimated, centrifugation, cleaved, triton, unconventional, uoroacetic, isotopic, lipoprotein, additionally, fractionated, solubilized, aminoacyltrna, subtype, contextdependent, yp170b, syn- thetases, hydroxyapatite, daltons, bonds, trend

46 Topic: 44 ace-1 0.050acetylcholinesterase- growth ace-2 catabolism 0.045- ace-3 metabolism cholinesterase 0.040- transferase

0.035- hormone enzyme cyclophilin 0.030- host

0.025- kynureninase nhr-2 0.020- cat-5 cat-3 odr-7 0.015- | cpl-1 | | flu-1 | nhr-23 0.010- flu-3 flu-4 flu-2 cyp-4 | ace-4 0.005- || || nhr-8 | | | | | | | | | | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: parasitophorous vacuolar membrane, parasitophorous vacuole, host cell plasma membrane; BP: drug metabolism CGC-based labels: biomass, ache, ace3, web, helminth, cy- clophilin, trophic, root, gst, ace, microbial, fungu, nr, plantparasitic, antibiotic, predator, mif, spp, tannin, capture, trap, microcosm, brugia, infective, incognita, parasites, caninum, habitat, arthrobotry, supply, ace4, microbivore, nematodetrapping, dependence, u2, parasitism, helminths, top, condensed, fungivore, ml1, ellagitannin, larial, greatest, hosts, represented, exploited, productivity, bacterivore, graph, ypd, aphe- lenchoide, fungal, forms, bacterialfeeding, antifungal, acrobeloide, cycloheximide, prey, lbp, predatory, cpl, wormpd, u3, microbe, agriculture, u1, qualitative, malayi, nematophagou, penetran, spore, trophiclevel, omnivore, cpl1, gallo, lph, xylophilu, veterinary, minititin, trapping, predaceou, bacteriophagou, ancylostoma

47 Topic: 45 receptor 0.050- sem-5 transporter vit-2 ovulation | 0.045- | growth pathogenesis host intracellular 0.040- hormone kinase 0.035- phosphatase virulence 0.030- binding

0.025- nucleus vit-3 pgp-2 fer-1 vit-1 ptp-2 0.020- clr-1 soc-1 egl-15 lfe-1 aha-1 pgp-3 let-23 pgp-4 0.015- itr-1 sli-1 phm-2 pgp-1 soc-2 abf-2 vit-6 ark-1 0.010- egl-9 lfe-2 vit-5 her-2 | egl-17 nhr-8 | | || | ahr-1 || | | vit-4 abf-1 0.005- | | | || | | ipp-5 | || | | | | | | | | | | | || | | | | | | | | | | | | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: amino acid binding, calcium ion binding, phospholipase d; CC: parasitophorous vacuolar membrane, parasitophorous vacuole, host cell plasma membrane, mitochondrial derivative, apical part of cell, basal part of cell; BP: regulation of beta 2 integrin biosynthesis, beta 2 integrin biosynthesis, regulation of fgf receptor signaling pathway, integrin biosynthesis, fgf receptor signaling pathway CGC- based labels: vitellogenin, fgf, sh3, vit2, pathogen, sh2, aeruginosa, vit5, vit6, glycoprotein, virulence, broblast, ip3, src, pgp1, fgfr, itr1, pgp3, clr1, vpe1, vit1, vpe2, pa14, grb2, cbl, typhimurium, lar, gluta- matergic, sem, trisphosphate, pseudomallei, vit3, vit4, sli, insp, soc, oncogene, similarly, vit, sos, ahr, rs, egfr, prolinerich, egl9, pathogenesi, soc2, ligandbinding, burkholderia, fkhr, pgp, clr, cyanide, lfe1, sf1, mucd, liprin, salmonella, fkhrl1, pa, estrogen, grampositive, hydrogen, steroid, drk, soc1, opportunistic, glucocorti- coid, neurexin, coil, afx, tractable, leucinerich, broad, pgp2, triphosphate, hostpathogen, vcbl, faecali, igfbp, pathogenicity, pyogene, ip3r, pathogenesis, ccbl, abf1, hced, pathogenic, sms

48 Topic: 46 receptor

0.050- daf-7 pheromone intracellular 0.045- daf-4 chemotaxis daf-1 0.040- nucleus cytoplasm 0.035- tab1 behavior development 0.030- growth

0.025- daf-12 daf-5 daf-22 med-6 sop-3 sre-1 skr-7 nsy-3 tax-4 adp-1 str-1 gcy-5 tax-6 gpa-5 egl-38 mab-18 che-11 odr-5 sro-1 - pkc-3 daf-28 0.020 odr-10 sma-6 odr-4 egl-5 che-13 daf-9 | unc-3 gcy-10 nsy-2 | tax-2 skp-1 daf-20 egl-26 str-2 daf-10 vab-3 lin-59 lin-17 daf-8 odr-3 gpa-2 sop-1 son-1 gcy-6 scd-2 0.015- daf-6 che-3 srg-8 daf-14 daf-2 unc-130 lin-23 unc-2 sra-7 daf-3 egl-4 str-3 med-7 odr-8 sra-9 odr-7 daf-16 sra-6 osm-3 egl2- unc-129 daf-11| odr-1 let-49 bra-1 0.010- | | | nsy-1 gcy-8 unc-36 | daf-21 osm-6 unc-31 cul-1 lin-48 lin-49 srb-6 egl-40 | odr-2 gpa-3 daf-19 gpa-1 | osm-9 sma-4 che-2 egl-32 srg-2 php-3 ||||| | srd-1 lim-4 gcy-7 cat-2 0.005- | | mab-9 kin-8 | | ttx-3 skr-1 skr-2 | | | | || | | | | | | | ||| | | | ||| | | | | | || | | || | || | | | ||| | | || | | | | | | | | | | || | | | || | | | | | | | | ||| | | | | | | || ||| | || | || | | | | || | ||| | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: microsome; BP: ethylene mediated signaling pathway, osmosensory signal- ing pathway via two-component system, two-component signal transduction system ’phosphorelay’, negative regulation of transcription by pheromones, positive regulation of transcription by pheromones, regulation of transcription from pol i promoter mitotic, ethylene mediated signaling pathway ’induced systemic resistance’, ethylene mediated signaling pathway ’jasmonic acid/ethylene dependent systemic resistance’, mapkkk cas- cade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, positive regulation of transcription from pol i promoter mitotic, negative regulation of transcription from pol ii promoter by pheromones, positive regulation of transcription from pol ii promoter by pheromones, adult feeding behav- ior, abscission, aging, regulation of transcription by pheromones, regulation of transcription mitotic, adult behavior, negative regulation of transcription mitotic, positive regulation of transcription mitotic, negative regulation of transcription from pol ii promoter mitotic, negative regulation of transcription from pol iii promoter mitotic, positive regulation of transcription from pol ii promoter mitotic, positive regulation of transcription from pol iii promoter mitotic, activation of mapk ’osmolarity sensing’, activation of mapkk ’os- molarity sensing’, activation of mapkkk ’osmolarity sensing’ CGC-based labels: olfactory, tgf, pheromone, odorant, daf1, daf11, daf3, daf8, daf14, tax2, odr10, tax4, twitchin, awc, odr, smad, awa, daf5, osm9, daf21, odr7, asi, odr3, cgmp, dafc, tax, mediator, olfaction, str2, cyclic, cka1, guanylyl, hindgut, sma6, egl38, diacetyl, chemosensation, dbl, betalike, nucleotidegated, daf22, discrimination, factorbeta, pax, skr, lin48, odr1, egl4, asg, pax6, dispersal, odorants, tab1, odr4, adp1, med6, odor, dafd, taste, dauerconstitutive, paired, odr2, thermosensation, skp1, dauerinducing, prp4k, synaptogyrin, elicit, overcrowding, str1, srd1, awe, nsy, lin49, tgfb, nsy1, str3, tak1, ig, vab3, sensed, galnactransferase

49 Topic: 47 integrin 0.050- pat-3 sarcolemma unc-52 cytoplasm 0.045- myofibril antibody 0.040- growth

0.035- proteoglycan enzyme membrane 0.030- cytoskeleton acetylglucosaminyltransferase

0.025- chaperone pat-4 gly-13 mig-2 ina-1 anc-1 0.020- gly-12 unc-97 fat-4 kin-8 unc-112 mig-15 kin-18 0.015- unc-84 unc-78 vab-1 deb-1 | unc-83 unc-89 | unc-60 - fat-3 0.010 pat-2 epi-1 | kin-16 fat-2 | fat-1 kin-15 gly-14 0.005- | | | cam-1 | | | || || | | | | | | ||| | | | || | | | | | | | | | | | || | | | | | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: mitochondrial outer membrane, intermediate lament cytoskeleton, mito- chondrial membrane, peroxisomal membrane; BP: CGC-based labels: fatty, integrin, desaturase, pat3, pufa, n3, ecm, polyunsaturated, vinculin, fat1, perlecan, n6, kettin, colin, pat2, actinbinding, deb1, depoly- merizing, lad, syk, talin, pat, unc84, cetm, unc112, pek, unc97, proteoglycan, phospholipid, glycan, heterol- ogou, rcm, omega3, pmk, pat4, arachidonic, kin15, kin16, tetratricopeptide, ptdcho, cro1, traf, pmp22, gas3, epa, ilk, laminin, fat, epi1, unc83, polymerization, unc78, elongase, palmitic, eel, eif, glycosyltransferase, acylation, igsf, mig15, omega, betaintegrin, alphaactinin, eicosapentaenoic, severing, hereditary, molecules, glycoconjugate, repertoire, fucose, linoleic, tao1, c01c10, dynamics, ncam, fat4, desaturated, desaturation, shp2, unsaturated, she4p, wd, disorganized, myobril, repeatcontaining

50 Topic: 48 binding 0.050- membrane fucosyltransferase acetylgalactosaminyltransferase 0.045- cytosol

0.040- chaperone acetylglucosaminyltransferase 0.035- transport spectrin 0.030- enzyme atpase |

0.025- avr-14 tub-1 0.020- gly-2 nex-3 gbr-2 nex-2 ben-1 0.015- gly-8 glc sup-35 jkk-1 mkk-4 0.010- jnk-1 cua-1 | avr-15 gly-3 | nex-1 rib-2 | 0.005- | mrp-1 arg-1 | | | | | | | | | | | | | | | | | | | || | | | | | || | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: amino acid binding, calcium ion binding; CC: mitochondrial outer membrane, mitochondrial membrane, peroxisomal membrane; BP: CGC-based labels: ivermectin, avermectin, glucl, cys, glutamategated, prolyl, mt, nematocidal, pdi, nex1, annexin, bz, ester, mal, metallothionein, mk, ivm, benzimidazole, glu, dissociation, disulde, analog, phytochelatin, picrotoxin, nh, galnac, cysteinerich, avr15, avermectinsensitive, jnk1, ckii, xaa, b1a, membranebound, valve, cemt, jkk1, contortus, glc, ben1, gammaaminobutyric, hydrolysi, gbr2, betasubunit, ch, detoxication, ionic, detergent, modied, substituted, paraherquamide, dioxapyrrolomycin, gly2, avr14, heparin, lec, published, immobilized, highanity

51 Topic: 49 axon

0.050- growth unc-6 0.045- unc-5 unc-40 0.040- receptor intracellular 0.035- chemoattractant

| gtpase | 0.030- development behavior

0.025- unc-53 ceh-10 mab-5 msi-1 unc-119 unc-130 mec-7 unc-2 lim-6 egl-20 max-1 gcy-8 0.020- unc-33 unc-30 vab-7 unc-71 ttx-1 kal-1 unc-47 unc-76 egl-27 dig-1 mig-18 unc-129 egl-17 unc-98 sax-2 mig-2 mig-17 clr-1 flp-1 0.015- unc-51 unc-34 mig-1 vab-3 cle-1 | lin-17 || ceh-14 unc-115 gon-1 egl-19 | ttx-3 tax-4 seu-2 unc-73unc-44 sax-3 egl-15 mig-14 mau-2 acr-5 0.010- | | egl-43 seu-3 | lin-11 sec-1 unc-3 vab-1 sax-1 | slt-1 mig-19 vab-8 unc-14 ina-1 unc-43 unc-39 - | ceh-23 unc-42 glr-1 0.005 || | ric-19 | | | unc-104 | | | || | | | || | | | | | | | | || | | | | | | | | | | | | || | || | | | || | | | || | || || | | | | | | || | | | | | | | | | - 0.000 | | | | | | | | | | | 1 50 100 150 200 250 300 350 400 450 500 GO-based labels: MF: ; CC: dynein; BP: ethylene mediated signaling pathway, osmosensory signaling pathway via two-component system, abscission, aging, two-component signal transduction system ’phospho- relay’, cell wall modication during abscission, determination of adult life span, adipocyte dierentiation, endothelial cell dierentiation, adult feeding behavior, negative regulation of transcription by pheromones, positive regulation of transcription by pheromones, regulation of transcription from pol i promoter mitotic, regulation of adipocyte dierentiation, regulation of endothelial cell dierentiation, ethylene mediated sig- naling pathway ’induced systemic resistance’, ethylene mediated signaling pathway ’jasmonic acid/ethylene dependent systemic resistance’, mapkkk cascade ’osmolarity sensing’, negative regulation of transcription from pol i promoter mitotic, positive regulation of transcription from pol i promoter mitotic, adult behavior, negative regulation of transcription from pol ii promoter by pheromones, positive regulation of transcrip- tion from pol ii promoter by pheromones CGC-based labels: axon, guidance, unc40, cone, netrin, unc73, outgrowth, migrating, unc44, ttx3, mig2, unc76, longitudinal, unc53, dorsoventral, vab8, dcc, aiy, pioneer, sax3, circumferential, branching, ceh14, unc34, unc129, unc71, midline, migrations, lim6, ceh10, bundle, thermosensory, unc14, pathnding, repulsion, posteriorly, sdqr, sec1, axons, afd, unc115, fasciculation, sax, mig1, anteriorly, repulsive, ceh23, munc18, ica69, placement, thermotaxi, motoneurone, ncs, pioneering, pitx2, guided, chemoattractant, mig14, db, dorsally, mig17, path, spike, longitudinally, ventrally, fascicle, vps41, robo, aiz

52