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Isbn 978-625-409-353-1
ISBN 978-625-409-353-1 INTERNATIONAL CONGRESS ON BIOLOGICAL AND HEALTH SCIENCES PROCEEDİNGS BOOK This work is subject to copyright and all rights reserved, whether the whole or part of the material is concerned. The right to publish this book belongs to International Congress on Biological and Health Sciences-2021. No part of this publication may be translated, reproduced, stored in a computerized system, or transmitted in any form or by any means, including, but not limited to electronic, mechanical, photocopying, recording without written permission from the publisher. This Proceedings Book has been published as an electronic publication (e-book). The publisher is not responsible for possible damages, which may be a result of content derived from this electronic publication All authors are responsible for the contents of their abstracts. https://www.biohealthcongress.com/ ([email protected]) Editor Ulaş ACARÖZ Published: 28/03/2021 ISBN: Editor's Note The first ‘International Congress on Biological and Health Sciences’ was organized online and free of charge. We are very happy and proud that various health science-related fields attended the congress. By this event, the distinguished and respected scientists came together to exchange ideas, develop and implement new researches and joint projects. There were 15 invited speakers from 10 different countries and also approximately 400 submissions were accepted from more than 20 countries. We would like to thank all participants and supporters. Hope to see you at our next congress. -
Tese Carlos 2018
UFRRJ PRÓ-REITORIA DE PESQUISA E PÓS-GRADUAÇÃO PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIA, TECNOLOGIA E INOVAÇÃO EM AGROPECUÁRIA TESE Estudo da Microbiota Bacteriana Endofítica de Cana-de-açúcar por Métodos Independentes de Cultivo: Diversidade, Perfil Taxonômico e Predição de Funções de Interesse Biotecnológico Carlos Magno dos Santos 2018 UNIVERSIDADE FEDERAL RURAL DO RIO DE JANEIRO PRÓ-REITORIA DE PESQUISA E PÓS-GRADUAÇÃO PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIA, TECNOLOGIA E INOVAÇÃO EM AGROPECUÁRIA ESTUDO DA MICROBIOTA BACTERIANA ENDOFÍTICA DE CANA- DE-AÇÚCAR POR MÉTODOS INDEPENDENTES DE CULTIVO: DIVERSIDADE, PERFIL TAXONÔMICO E PREDIÇÃO DE FUNÇÕES DE INTERESSE BIOTECNOLÓGICO CARLOS MAGNO DOS SANTOS Sob a Orientação do Pesquisador Stefan Schwab e Coorientação do Pesquisador José Ivo Baldani Tese submetida como requisito parcial para obtenção do grau de Doutor, no Programa de Pós- graduação em Ciência, Tecnologia e Inovação em Agropecuária, Área de Concentração em Agrobiologia Seropédica, RJ Fevereiro, 2018 Santos, Carlos Magno dos, 1990- S237e Estudo da microbiota bacteriana endofítica de cana de-açúcar por métodos independentes de cultivo: diversidade, perfil taxonômico e predição de funções de interesse biotecnológico / Carlos Magno dos Santos Santos. - 2018. 131 f.: il. Orientador: Stefan Schwab. Coorientador: José Ivo Baldani. Tese(Doutorado). -- Universidade Federal Rural do Rio de Janeiro, Ciência, Tecnologia e Inovação em Agropecuária, 2018. 1. Enriquecimento celular. 2. Independente de cultivo. 3. Líquido do apoplasto. 4. Colmo. 5. Sphingomonas. I. Schwab, Stefan, 1975-, orient. II. Baldani, José Ivo, 1953-, coorient. III Universidade Federal Rural do Rio de Janeiro. Ciência, Tecnologia e Inovação em Agropecuária. IV. Título. É permitida a cópia parcial ou total desta Tese, desde que citada a fonte. -
Examining the Antimicrobial Activity of Cefepime-Taniborbactam
Examining the antimicrobial activity of cefepime-taniborbactam (formerly cefepime/VNRX-5133) against Burkholderia species isolated from cystic fibrosis patients in the United States Elise T. Zeiser1, Scott A. Becka1, John J. LiPuma2, David A. Six 3, Greg Moeck 3, and Krisztina M. Papp-Wallace1,4 1Veterans Affairs Northeast Ohio Healthcare System, Cleveland, OH; 2University of Michigan, Ann Arbor, MI; 3Venatorx 4 Pharmaceuticals, Inc., Malvern, PA; and Case Western Reserve University, Cleveland, OH Correspondence to: [email protected] Abstract Results Background: Burkholderia cepacia complex (Bcc), a group of >20 related species, and B. gladioli are 60 opportunistic human pathogens that cause chronic infections in people with cystic fibrosis (CF) or cefepime compromised immune systems. Ceftazidime and trimethoprim-sulfamethoxazole are first-line agents used to treat infections due to Burkholderia spp. However, these species have developed resistance to cefepime-taniborbactam many antibiotics, including first-line therapies. β-lactam resistance in Burkholderia species is largely 40 mediated by PenA-like chromosomal class A β-lactamases. A novel investigational β-lactam/β-lactamase inhibitor combination, cefepime-taniborbactam (formerly cefepime/VNRX-5133) demonstrates potent antimicrobial activity against gram-negative bacteria producing class A, B, C, and D β-lactamases. The activity of cefepime-taniborbactam was investigated against Bcc and B. gladioli; moreover, the biochemical activity of taniborbactam against the PenA1 carbapenemase was evaluated. 20 Methods: CLSI-based agar dilution antimicrobial susceptibility testing using cefepime and cefepime combined with taniborbactam at 4 mg/L was conducted against a curated panel of 150 Burkholderia species obtained from the Burkholderia cepacia Research Laboratory and Repository. Isolates were Number isolates of recovered from respiratory specimens from 150 different individuals with CF receiving care in 68 cities 0 throughout 36 states within the United States. -
Yersinia Enterocolitica
TECHNISCHE UNIVERSITÄT MÜNCHEN Lehrstuhl für Mikrobielle Ökologie Regulation und Freisetzung des insektiziden Komplexes in Yersinia enterocolitica Mandy Starke Vollständiger Abdruck der von der Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt der Technischen Universität München zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften genehmigten Dissertation. Vorsitzender: Univ.- Prof. Dr. W. Liebl Prüfer der Dissertation: 1. apl. Prof. Dr. T. Fuchs 2. Univ.-Prof. Dr. M. Hofrichter (nur schriftliche Beurteilung) Technische Universität Dresden Univ.-Prof. Dr. S. Scherer (nur mündliche Prüfung) 3. Univ.-Prof. Dr. J. Heesemann (i.R.) Ludwigs-Maximilians-Universität München Die Dissertation wurde am 10.11.2014 bei der Technischen Universität München eingereicht und durch die Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt am 17.03.2015 angenommen. “Alles Wissen und alle Vermehrung unseres Wissens endet nicht mit einem Schlusspunkt, sondern mit einem Fragezeichen.“ -Hermann Hesse- Inhaltsverzeichnis I Inhaltsverzeichnis ABBILDUNGSVERZEICHNIS ........................................................................................................... V TABELLENVERZEICHNIS .............................................................................................................. VII ABKÜRZUNGSVERZEICHNIS ..................................................................................................... VIII ZUSAMMENFASSUNG ................................................................................................................... -
Table S4. Phylogenetic Distribution of Bacterial and Archaea Genomes in Groups A, B, C, D, and X
Table S4. Phylogenetic distribution of bacterial and archaea genomes in groups A, B, C, D, and X. Group A a: Total number of genomes in the taxon b: Number of group A genomes in the taxon c: Percentage of group A genomes in the taxon a b c cellular organisms 5007 2974 59.4 |__ Bacteria 4769 2935 61.5 | |__ Proteobacteria 1854 1570 84.7 | | |__ Gammaproteobacteria 711 631 88.7 | | | |__ Enterobacterales 112 97 86.6 | | | | |__ Enterobacteriaceae 41 32 78.0 | | | | | |__ unclassified Enterobacteriaceae 13 7 53.8 | | | | |__ Erwiniaceae 30 28 93.3 | | | | | |__ Erwinia 10 10 100.0 | | | | | |__ Buchnera 8 8 100.0 | | | | | | |__ Buchnera aphidicola 8 8 100.0 | | | | | |__ Pantoea 8 8 100.0 | | | | |__ Yersiniaceae 14 14 100.0 | | | | | |__ Serratia 8 8 100.0 | | | | |__ Morganellaceae 13 10 76.9 | | | | |__ Pectobacteriaceae 8 8 100.0 | | | |__ Alteromonadales 94 94 100.0 | | | | |__ Alteromonadaceae 34 34 100.0 | | | | | |__ Marinobacter 12 12 100.0 | | | | |__ Shewanellaceae 17 17 100.0 | | | | | |__ Shewanella 17 17 100.0 | | | | |__ Pseudoalteromonadaceae 16 16 100.0 | | | | | |__ Pseudoalteromonas 15 15 100.0 | | | | |__ Idiomarinaceae 9 9 100.0 | | | | | |__ Idiomarina 9 9 100.0 | | | | |__ Colwelliaceae 6 6 100.0 | | | |__ Pseudomonadales 81 81 100.0 | | | | |__ Moraxellaceae 41 41 100.0 | | | | | |__ Acinetobacter 25 25 100.0 | | | | | |__ Psychrobacter 8 8 100.0 | | | | | |__ Moraxella 6 6 100.0 | | | | |__ Pseudomonadaceae 40 40 100.0 | | | | | |__ Pseudomonas 38 38 100.0 | | | |__ Oceanospirillales 73 72 98.6 | | | | |__ Oceanospirillaceae -
Extensive Microbial Diversity Within the Chicken Gut Microbiome Revealed by Metagenomics and Culture
Extensive microbial diversity within the chicken gut microbiome revealed by metagenomics and culture Rachel Gilroy1, Anuradha Ravi1, Maria Getino2, Isabella Pursley2, Daniel L. Horton2, Nabil-Fareed Alikhan1, Dave Baker1, Karim Gharbi3, Neil Hall3,4, Mick Watson5, Evelien M. Adriaenssens1, Ebenezer Foster-Nyarko1, Sheikh Jarju6, Arss Secka7, Martin Antonio6, Aharon Oren8, Roy R. Chaudhuri9, Roberto La Ragione2, Falk Hildebrand1,3 and Mark J. Pallen1,2,4 1 Quadram Institute Bioscience, Norwich, UK 2 School of Veterinary Medicine, University of Surrey, Guildford, UK 3 Earlham Institute, Norwich Research Park, Norwich, UK 4 University of East Anglia, Norwich, UK 5 Roslin Institute, University of Edinburgh, Edinburgh, UK 6 Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Banjul, The Gambia 7 West Africa Livestock Innovation Centre, Banjul, The Gambia 8 Department of Plant and Environmental Sciences, The Alexander Silberman Institute of Life Sciences, Edmond J. Safra Campus, Hebrew University of Jerusalem, Jerusalem, Israel 9 Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK ABSTRACT Background: The chicken is the most abundant food animal in the world. However, despite its importance, the chicken gut microbiome remains largely undefined. Here, we exploit culture-independent and culture-dependent approaches to reveal extensive taxonomic diversity within this complex microbial community. Results: We performed metagenomic sequencing of fifty chicken faecal samples from Submitted 4 December 2020 two breeds and analysed these, alongside all (n = 582) relevant publicly available Accepted 22 January 2021 chicken metagenomes, to cluster over 20 million non-redundant genes and to Published 6 April 2021 construct over 5,500 metagenome-assembled bacterial genomes. -
1985517720.Pdf
JOURNAL OF BACTERIOLOGY, Jan. 2009, p. 347–354 Vol. 191, No. 1 0021-9193/09/$08.00ϩ0 doi:10.1128/JB.01238-08 Copyright © 2009, American Society for Microbiology. All Rights Reserved. Complete Genome Sequence and Comparative Genome Analysis of Enteropathogenic Escherichia coli O127:H6 Strain E2348/69ᰔ† Atsushi Iguchi,1 Nicholas R. Thomson,2 Yoshitoshi Ogura,1,3 David Saunders,2 Tadasuke Ooka,3 Ian R. Henderson,4 David Harris,2 M. Asadulghani,1 Ken Kurokawa,5 Paul Dean,6 Brendan Kenny,6 Michael A. Quail,2 Scott Thurston,2 Gordon Dougan,2 Tetsuya Hayashi,1,3 Julian Parkhill,2 and Gad Frankel7* Division of Bioenvironmental Science, Frontier Science Research Center,1 and Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine,3 University of Miyazaki, Miyazaki, Japan; Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom2; School of Immunity and Infection, University of Downloaded from Birmingham, Birmingham, United Kingdom4; Department of Biological Information, School and Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Kanagawa, Japan5; Institute of Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, United Kingdom6; and Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom7 Received 5 September 2008/Accepted 15 October 2008 Enteropathogenic Escherichia coli (EPEC) was the first pathovar of E. coli to be implicated in human disease; however, no EPEC strain has been fully sequenced until now. Strain E2348/69 (serotype O127:H6 belonging to E. http://jb.asm.org/ coli phylogroup B2) has been used worldwide as a prototype strain to study EPEC biology, genetics, and virulence. -
Aliarcobacter Butzleri from Water Poultry: Insights Into Antimicrobial Resistance, Virulence and Heavy Metal Resistance
G C A T T A C G G C A T genes Article Aliarcobacter butzleri from Water Poultry: Insights into Antimicrobial Resistance, Virulence and Heavy Metal Resistance Eva Müller, Mostafa Y. Abdel-Glil * , Helmut Hotzel, Ingrid Hänel and Herbert Tomaso Institute of Bacterial Infections and Zoonoses (IBIZ), Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 07743 Jena, Germany; Eva.Mueller@fli.de (E.M.); Helmut.Hotzel@fli.de (H.H.); [email protected] (I.H.); Herbert.Tomaso@fli.de (H.T.) * Correspondence: Mostafa.AbdelGlil@fli.de Received: 28 July 2020; Accepted: 16 September 2020; Published: 21 September 2020 Abstract: Aliarcobacter butzleri is the most prevalent Aliarcobacter species and has been isolated from a wide variety of sources. This species is an emerging foodborne and zoonotic pathogen because the bacteria can be transmitted by contaminated food or water and can cause acute enteritis in humans. Currently, there is no database to identify antimicrobial/heavy metal resistance and virulence-associated genes specific for A. butzleri. The aim of this study was to investigate the antimicrobial susceptibility and resistance profile of two A. butzleri isolates from Muscovy ducks (Cairina moschata) reared on a water poultry farm in Thuringia, Germany, and to create a database to fill this capability gap. The taxonomic classification revealed that the isolates belong to the Aliarcobacter gen. nov. as A. butzleri comb. nov. The antibiotic susceptibility was determined using the gradient strip method. While one of the isolates was resistant to five antibiotics, the other isolate was resistant to only two antibiotics. The presence of antimicrobial/heavy metal resistance genes and virulence determinants was determined using two custom-made databases. -
Quadram Institute Newsletter
Autumn 2019 Welcome to the newsle�er of the Quadram Ins�tute. This issue highlights recent research breakthroughs at the We con�nue to build our team and are pleased to welcome Quadram Ins�tute (QI) that could have posi�ve impacts on Professor Cynthia Whitchurch to the QI. Cynthia is se�ng public health. Working with clinicians our researchers have up a research group inves�ga�ng bacterial lifestyles, and shown how the latest sequencing technologies can aid in how these make them more infec�ous or resistant to diagnos�cs and surveillance. Coupling these techniques an�microbials. Cynthia joins us from the ithree ins�tute at with ‘Big Data’ analy�cal approaches will be vital to the University of Technology Sydney. Her research led to addressing 21st century popula�on health challenges, and the discovery that extracellular DNA is required for biofilm the QI aims to be a leader in this area. development. Big Data in the NHS was the topic of a roundtable We con�nue to welcome visitors to our new building to discussion I a�ended with Patricia Hart at the policy share our vision to understand how food and microbes development think tank Reform. This roundtable was interact to promote health and prevent disease. In June, we sponsored by QI and explored how universi�es and industry had the honour of hos�ng His Excellency Simon Smits, can work with government to realise poten�al applica�ons Ambassador of the Netherlands to the UK. The Ambassador of Big Data. The event was chaired by Baroness Blackwood, visited the Norwich Research Park as part of an Parliamentary Under-Secretary of State, Department of interna�onal trade delega�on to East Anglia to learn about Health and Social Care (DHSC) and included senior the region’s world-leading life sciences research and trade policy-makers, public service prac��oners, academics and opportuni�es. -
Curriculum Vitae Professor Mark John Pallen
Curriculum Vitae Professor Mark John Pallen MA (Hons) Cantab, MBBS, MD, PhD January 2014 Mark Pallen — Curriculum vitae Personal Details Name Mark John Pallen Date of Birth 6 July 1960 Nationality British Address 17 Lodge Drive, Malvern Worcestershire, WR14 4LS E-mail address [email protected] Telephone 01684 567710 (home); 07824 086946 (mobile) Web Page: http://tinyurl.com/ncul2p3 Twitter: http://twitter.com/mjpallen YouTube Channel: http://www.youtube.com/user/pallenm/ Education and Qualifications PhD 1998 Imperial College, London An investigation into the links between stationary phase and virulence in Salmonella enterica enterica serovar Typhimurium MD 1993 St Bartholomew's Hospital Medical College Detection and characterisation of diphtheria toxin genes and insertion sequences MRCPath by examination in Medical Microbiology 1991 (upgraded to FRCPath 2005) MB BS 1981-84 London Hospital Medical College Undergraduate Prizes: LEPRA National Essay Prize, 1982 Turnbull Prize in Pathology, 1983, 1984 Sutton Prize in Pathology, 1983 BA (Hons) in Medical Sciences 1978-81 University of Cambridge Fitzwilliam College (Lower Second, converted to MA, 1985) Page 1 Mark Pallen — Curriculum vitae Employment Professor of Microbial Genomics Head of Division of Microbiology and Infection Apr 2013-now Warwick Medical School, University of Warwick Professor of Microbial Genomics 2001-2013 University of Birmingham Professor and Head of Department 1999-2001 Department of Microbiology and Immunobiology Queen’s University, Belfast Senior Lecturer (Honorary Consultant) 1992–99 Department of Medical Microbiology St Bartholomew's and the Royal London School of Medicine and Dentistry (Queen Mary Westfield College) Visiting Research Fellow 1994–97 Department of Biochemistry Imperial College of Science, Technology and Medicine (on a Wellcome Trust Research Leave Fellowship, working at Imperial, while still employed by Barts) Lecturer (Hon. -
Epidemiology and Comparative Analysis of Yersinia in Ireland Author(S) Ringwood, Tamara Publication Date 2013 Original Citation Ringwood, T
UCC Library and UCC researchers have made this item openly available. Please let us know how this has helped you. Thanks! Title Epidemiology and comparative analysis of Yersinia in Ireland Author(s) Ringwood, Tamara Publication date 2013 Original citation Ringwood, T. 2013. Epidemiology and comparative analysis of Yersinia in Ireland. PhD Thesis, University College Cork. Type of publication Doctoral thesis Rights © 2013, Tamara Ringwood http://creativecommons.org/licenses/by-nc-nd/3.0/ Item downloaded http://hdl.handle.net/10468/1294 from Downloaded on 2021-10-07T12:07:10Z Epidemiology and Comparative Analysis of Yersinia in Ireland by Tamara Ringwood A thesis presented for the Degree of Doctor of Philosophy National University of Ireland, Cork University College Cork Coláiste na hOllscoile Corcaigh Department of Microbiology Head of Department: Prof. Gerald F. Fitzgerald Supervisor: Prof. Michael B. Prentice April 2013 Contents List of Tables .............................................................................................................................................. iv List of figures ............................................................................................................................................. vi Declaration ............................................................................................................................................... viii Acknowledgements ................................................................................................................................ -
Clinical Isolates of Yersinia Enterocolitica in Finland 117 2013 117
Leila M. Sihvonen Leila Leila M. Sihvonen Clinical isolates of Yersinia enterocolitica in Finland Leila M. Sihvonen Identification and Epidemiology Clinical isolates of Yersinia enterocolitica in Finland Identification and Epidemiology Clinical isolates of Clinical isolates Yersinia enterocolitica is a foodborne bacterium that causes gastroenteritis and post-infectious complications, such as reactive arthritis, in humans. Y. enterocolitica species is divided into six biotypes, which differ in their ability to cause illness. The Y. enterocolitica incidence in Finland has been among the highest in the EU, but there has been little information on the occurrence of different Y. enterocolitica biotypes. enterocolitica Yersinia In this thesis Y. enterocolitica strains isolated from Finnish patients were characterised and the symptoms and sources of infections were analysed RESEARCH RESEARCH in a case-control study. The majority of clinical isolates of Y. enterocolitica were found to belong to biotype 1A, the status of which as a true pathogen is controversial. Furthermore, the study investigated the microbiological identification and molecular typing methods for Y. enterocolitica. The MLVA method was found to be appropriate for investigating foodborne outbreaks. in Finland This study adds to the understanding of epidemiology of Y. enterocolitica in Finland and emphasises the importance of correct identification of Yersinia strains in order to evaluate the clinical importance of the microbiological findings. National Institute for Health and Welfare P.O. Box 30 (Mannerheimintie 166) FI-00271 Helsinki, Finland 117 Telephone: 358 29 524 6000 117 117 2013 ISBN 978-952-302-064-1 www.thl.fi RESEARCH NRO 117 2014 Leila M. Sihvonen Clinical isolates of Yersinia enterocolitica in Finland Identification and Epidemiology ACADEMIC DISSERTATION To be presented with the permission of the Faculty of Agriculture and Forestry, University of Helsinki, for public examination in Auditorium 1041, Biocenter 2, Viikinkaari 5, on 17.01.2014, at 12 noon.