T cell receptor signaling pathway (genes with data) PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway (sink nodes) PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway BL PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway intermediate PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway DLBCL PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway FL/DLBCL PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway FL PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway other PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway cell line PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway B−cells PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis T cell receptor signaling pathway tonsil PDCD1 CTLA4 PTPN6
PTPRC −p −p −p −p Ubiquitin mediated CD4 LCK +u CBLC +u proteolysis +p +u CD3E +p FYN CD3G +p DLG1 K10784CD247 +p K10785CD247 ZAP70 MAPK14 Cell adhesion CD3D +p Regulation of +p LCP2 NCK1+p PAK4... molecules (CAMs)CD3E actin cytoskeleton GRAP2 LAT VAV3... RHOA +p ITKCalcium signaling pathway GRB2 +p PLCG1 C01245 C00076 PPP3CA −p NFATC1 IL2 IL4 IL5 SOS1 RASGRP1HRAS RAF1+pMAP2K1+pMAPK1 +p FOS IL10 IFNG MAPK signaling pathway CSF2 +p TNF CDK4 MAP3K7+pMAP2K7+pMAPK9 NF−kappa B signaling pathway +p +p NFKB1 CD40LG C00165 PRKCQ CARD11 +p # BCL10 +u IKBKB +p NFKBIA PI3K−Akt signaling MALT1 IKBKG ICOS pathway +pCHUK PIK3R5C05981 AKT3+pMAP3K8+pMAP3K14 CD28 +p +p PDPK1 GRB2 GSK3B Ubiquitin mediated proteolysis