SUPPLEMENTARY DATA Supplementary Table 1. Genes

SUPPLEMENTARY DATA

Supplementary Table 1. Genes differentially expressed in microarray in the dorsocervical vs. the abdominal s.c. adipose tissue in the cART+LD+ group.

Abbreviation Gene name Accession no. MDF

Cell proliferation

SFRP4 secreted frizzled-related protein 4 NM_003014 -1.9

Organogenesis and regulation of transcription

ZIC1 zic family member 1 NM_003412 3.6

ZIC4 zic family member 4 NM_032153 2.2

EYA4 eyes absent homolog 4 NM_004100 1.7

SHOX2 short stature homeobox 2 NM_006884 1.4

HOXB5 homeobox B5 NM_002147 1.0

HOXA4 homeobox A4 NM_002141 0.8

TCF21 transcription factor 21 NM_003206 -0.8

FOXF2 forkhead box F2 NM_001452 -0.9

OSR1 odd-skipped related 1 NM_145260 -0.9

PITX2 paired-like homeodomain 2 NM_153426 -1.0

PRRX1 paired related homeobox 1 NM_006902 -1.0

CYR61 cysteine-rich, angiogenic inducer 61 NM_001554 -1.1

NKX2-1 NK2 homeobox 1 NM_003317 -1.1

HAND2 heart and neural crest derivatives expressed 2 NM_021973 -1.5

HOXA7 homeobox A7 NM_006896 -1.7

HOXC8 homeobox C8 NM_022658 -1.8

HOXC9 homeobox C9 NM_006897 -1.9

DMRT3 doublesex and mab-3 related transcription factor 3 NM_021240 -2.1

HOXA9 homeobox A9 NM_152739 -2.2

HOXA10 homeobox A10 NM_018951 -2.4

Cell adhesion

CDH23 cadherin-like 23 NM_022124 0.6

PGM5 phophoglucomutase 5 NM_021965 -0.7

CPXM2 carboxypeptidase X (M14 family), member 2 NM_198148 -0.9

FN1 fibronectin 1 NM_212482 -0.9

CLDN11 claudin 11 AF085871 -1.0

Cytoskeleton

STMN2 stathmin-like 2 NM_007029 1.5

PDLIM5 PDZ and LIM domain 5 NM_006457 -0.5

CALD1 caldesmon 1 AK022222 -0.6

STMN3 stathmin-like 3 NM_015894 -0.6

ANK2 ankyrin 2, neuronal NM_001148 -0.7

DPYSL3 dihydropyrimidinase-like 3 NM_001387 -1.0

SPAG17 sperm associated antigen 17 NM_206996 -1.1

PDLIM3 PDZ and LIM domain 3 BC001017 -1.3

Extracellular matrix

ADAMTS3 ADAM metallopeptidase with thrombospondin type NM_014243 -1.0 1 motif 3

ELN elastin NM_000501 -1.1

MGP matrix Gla protein NM_000900 -1.3

ASPN asporin NM_017680 -1.6

CTGF connective tissue growth factor NM_001901 -1.6

Energy metabolism

PPP1R3B protein phosphatase 1, regulatory (inhibitor) subunit NM_024607 -0.6 3B

ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 NM_001776 -0.6

ATP8B4 ATPase, class I, type 8B, member 4 NM_024837 -1.0

Immune response and inflammation

PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 NM_152309 -0.6

TNFAIP8L3 tumor necrosis factor, alpha-induced protein 8-like 3 NM_207381 -0.6

SAMHD1 SAM domain and HD domain 1 NM_015474 -0.7

TAGAP T-cell activation RhoGTPase activating protein NM_054114 -0.7

CD55 CD55 molecule NM_000574 -0.8

C1QTNFF7 C1q and tumor necrosis factor related protein 7 NM_031911 -0.9

MRC1L1 mannose receptor, C type 1-like 1 NM_001009567 -1.0

CD163 CD163 molecule NM_004244 -1.1

CYBB cytochrome b-245, beta polypeptide NM_000397 -1.1

C1QTNF3 C1q and tumor necrosis factor related protein 3 NM_181435 -1.3

Metabolism

PON3 paraoxonase 3 NM_000940 0.7

DIO3 deiodinase, iodothyronine, type III NM_001362 -0.8

ALDH1A1 aldehyde dehydrogenase 1 family member A1 NM_000689 -1.1

ALDH1A3 aldehyde dehydrogenase 1 family member A3 NM_000693 -1.2

Molecular transport

SLCO2B1 solute carrier organic anion transporter family, NM_007256 -0.9 member 2B1

CP ceruloplasmin NM_000096 -1.0

LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 NM_006691 -1.4

Signal transduction

ALPK2 alpha-kinase 2 NM_052947 1.1

RET ret proto-oncogene NM_020975 1.1

AKAP13 A kinase (PRKA) anchor protein 13 NM_006738 -0.6

PIK3CG phosphoinositide-3-kinase, catalytic, gamma NM_002649 -0.6 polypeptide

PLK3 polo-like kinase 3 NM_004073 -0.6

GEM GTP binding protein overexpressed in skeletal NM_005261 -0.7 muscle

MERTK c-mer proto-oncogene tyrosine kinase U080823 -0.7

DACT2 dapper, antagonist of beta-catenin, homolog 2 NM_214462 -1.4

Miscellaneous

MUM1L1 melanoma associated antigen (mutated) 1-like 1 NM_152423 1.3

LSDP5 lipid storage droplet protein 5 NM_001013706 1.1

LOC404266 hypothetical LOC404266 BC010732 1.0

ART4 ADP-ribosyltransferase 4 NM_021071 -0.7

C5orf13 chromosome 5 open reading frame 13 NM_004772 -0.7

PLEKHA6 pleckstrin homology domain containing, family A NM_014935 -1.0 member 6

TMEM200A transmembrane protein 200A NM_052913 -1.0

ITM2A intergal memebrane protein 2A NM_004867 -1.1

The differentially expressed genes are classified into functional categories (given in alphabetical order) and listed according to their mean fold difference (MFD) within each category.

Supplementary Table 2. Genes differentially expressed in microarray in the dorsocervical vs. the abdominal s.c. adipose tissue in the cART+LD- group.

Abbreviation Gene name Accession no. MDF

Cytoskeleton

SPAG17 sperm associated antigen 17 NM_206996 -1.3

Organogenesis and regulation of transcription

ZIC1 zic family member 1 NM_003412 3.8

ZIC4 zic family member 4 NM_032153 2.2

SHOX2 short stature homeobox 2 NM_006884 1.4

HAND2 heart and neural crest derivatives expressed 2 NM_021973 -1.4

HOXC9 homeobox C9 NM_006897 -2.0

HOXC8 homeobox C8 NM_022658 -2.1

HOXA10 homeobox A10 NM_018951 -2.2

Immune respons and inflammation

MSR1 macrophage scavenger reseptor 1 NM_138715 -1.3

Metabolism

FMO flavin containing monooxygenase NM_001002294 -0.9

ALDH1A1 aldehyde dehydrogenase 1 family member A1 NM_000689 -1.3

Signal transduction

ALPK2 alpha-kinase 2 NM_052947 1.4

Miscellaneous

C18orf34 chromosome 18 open reading frame 34 NM_001105528 -1.1

The differentially expressed genes are classified into functional categories (given in alphabetical order) and listed according to their mean fold difference (MFD) within each category.