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Rabbit Anti-SH2D3A/FITC Conjugated antibody

SL6158R-FITC

Product Name: Anti-SH2D3A/FITC Chinese Name: FITC标记的SH2结构域蛋白3A抗体 Novel SH2 containing 1; NSP1; SH2 domain containing 3A; SH2 domain Alias: containing protein 3A; SH23A_HUMAN. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Pig,Cow,Sheep, IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 63kDa Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human NSP1/SH2D3A Lsotype: IgG Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storewww.sunlongbiotech.com at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: SH2D3A is a 576 amino acid protein that is thought to play a role in JNK activation. SH2D3A interacts with p130 Cas and is found at low levels in fetal kidney, fetal lung, placenta, adult pancreas, kidney and lung. Subject to post-translational phosphorylation Product Detail: on multiple tyrosine residues, SH2D3A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target , frequently linking activated growth factors to putative signal transduction proteins. The encoding SH2D3A maps to human 19, which consists of over 63 million bases, houses approximately 1,400 and is recognized for having the greatest gene density of the human . It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig- like receptors, a number of ICAMs, the CEACAM and PSG families and Fc receptors (FcRs).

Function: May play a role in JNK activation.

Subunit: Interacts with BCAR1.

Tissue Specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.

Post-translational modifications: Phosphorylated on tyrosine.

Similarity: Contains 1 SH2 domain.

Database links:

Entrez Gene: 10045 Human

GenBank: BC006281 Human

Omim: 604721 Human

SwissProt: Q9BRG2 Human

Unigene: 439645 Human www.sunlongbiotech.com Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.