4/2013 Volume 30, No. 4 ISSN 1868-596X 409-564 (2013) Altex Alternatives to animal experimentation
Food for thought … John M. Greally and Thomas Hartung and Miriam N. Jacobs: Emanuela Corsini: In vitro and in vivo testing Immunotoxicology: methods of epigenomic Challenges in endpoints for evaluating the 21st century and endocrine disruptors in vitro opportunities t4 report: Stefan Schildknecht, Mardas Daneshian, Christiaan Karreman, Luis M. Botana, Marie-Yasmine Dominik Pöltl, Liudmila Efrémova, Dechraoui Bottein, Cornelius Kullmann, Gemma Buckland, Mònica Simon Gutbier, Anne Krug, Campàs, Ngaire Dennison, Diana Scholz, Hanne R. Robert W. Dickey, Gerding, and Marcel Leist: Jorge Diogène, Valérie Fessard, Generation of Thomas Hartung, Andrew genetically-modified Humpage, Marcel Leist, Jordi human differentiated cells Molgó, Michael A. Quilliam, for toxicological tests and Costanza Rovida, Benjamin the study of A. Suarez-Isla, Aurelia Tubaro, neurodegenerative Kristina Wagner, Otmar Zoller, diseases and Daniel Dietrich: A roadmap for hazard Cameron MacKay, monitoring and risk Michael Davies, assessment of marine Vicki Summerfield, biotoxins on the basis of and Gavin Maxwell: chemical and biological test From pathways to people: systems Applying the adverse outcome pathway (AOP) Calendar of events for skin sensitization to Corners risk assessment News Humane Science in the 21st Century
9th World Congress on Alternatives and Animal Use in the Life Sciences 24–28 August 2014 | Prague, Czech Republic | www.wc9prague.org
Scientifi c Programme – draft April 2013 8. Refi nement and welfare Registration 1. New technologies a. NHPs To register, please use exclusively our internet a. Virtual tissue models b. Primates registration form at www.wc9prague.org. The form b. HTS c. Welfare approaches will be opened in October 2013. c. BIG data d. Humane principles in experimental techniques d. Novel computational biology tools e. Avoidance of severe suffering Registration fees e. Tissue on a chip Payment f. 3D models 9. Global cooperation, regulatory acceptance, g. Bioreactors standardization h. Bioimaging a. Regulatory acceptance of alternatives i. Monitoring, telemetry b. Progressing validation j. Advanced human-based diagnostic techniques c. Update from validation centers k. New readout technologies d. Good cell culture practice e. Challenges to 3Rs registration Early 2014 1, June by on Late registration 2014 1, & after June On-site registration Full Participation 530 580 635 2. Predictive Toxicology and safety assessment f. Barriers for international harmonization and € € € Full Participation, Students 380 430 475 a. Pathway approaches in toxicology (AOP) mutual acceptance € € € / young scientistic* b. Systems biology (-omics) g. Legal constrains and uncertainties Accompanying Person € 300 € 350 € 390 c. Update on Tox21 h. Trade barriers d. Update on SEURAT-1 i. Animal welfare implementation across the world *Students/young scientists under 30 are eligible when e. Exposure j. Update from international societies presenting an offi cial confi rmation of enrolment f. Topical toxicity at a scientifi c institution. g. Repeated dose toxicity The abstracts will be published in an h. Skin sensitization international scientifi c journal focused on 3Rs The Full Participation includes: i. Endocrine disruption with impact factor. Admission to all scientifi c events and exhibition, the j. Genotoxicity / Carcinogenicity Opening and Closing Cremony, the Get-Together k. Reproductive and developmental toxicology Congress Co-Chairs Party on Sunday, the Welcome Cocktail on Monday, l. Inhalation toxicity Dagmar Jírová the Gala Dinner on Wednesday, coffee breaks and m. Ecotoxicology Horst Spielmann light lunches. n. Computational modeling and chem-informatics (e.g. QSAR, mechanistic chemistry) ACT Members The registration fee for Accompanying o. Risk assessment (e.g. chemicals, drugs, biocides, Herman Koëter Persons includes: food, cosmetics, medical devices, nano materials, Acting Chairman, Secretary, Belgium The Opening and Closing Ceremony, the Get-Together mixtures, biologicals etc.) Thomas Hartung Party on Sunday, the Welcome Cocktail on Monday, p. Application in decision making and testing Treasurer, United States of America the Gala Dinner on Wednesday. strategies Michael Balls United Kingdom The registration fees do not include accommodation 3. 3Rs in academia and education Coenraad Hendriksen and travel costs. a. Information requirements on researchers Netherlands (e.g. Directive 63/2010) Andrew Rowan Congress Secretariat b. Training programs and anticipated needs United States of America GUARANT International spol. s r.o. c. 3Rs in academic education Horst Spielmann Na Pankráci 17, 140 21 Prague 4, Czech Republic d. Funding programs (e.g. Horizon 2020) Germany Tel.: +420 284 001 444, fax: +420 284 001 448 e. Funding agencies E-mail: [email protected] f. Innovative teaching and training tools Committees Website: www.wc9prague.org g. Benefi ts of 3Rs – case studies Scientifi c Programme Committee Nathalie Alépée L‘Oréal, France General Information 4. Communication, dissemination and data Kevin Crofton US EPA, United States of America Congress Venue sharing Miroslav Červinka Charles University, Czech Republic Hotel Hilton Prague a. Scientifi c reporting standards Mardas Daneshian CAAT Europe, Germany Pobřežní 311/1, 186 00, Prague 8 – Karlín b. Retrospective analysis / non-technical summaries Chantra Eskes ESTIV, Switzerland Czech Republic (63/2010) Tuula Heinonen SSCT & ECOPA, Finland c. Information systems and databases Helena Kanďárová SETOX & MatTek, Slovak Republic Important Dates d. Intellectual property and data ownership Hajime Kojima JaCVAM, Japan Registration Opens October 2013 Roman Kolar Eurogroup for Animals, Germany Abstract Submission Opens October 2013 5. Effi cacy and safety testing of drugs and Robert Landsiedel BASF, Germany Abstract Submission Deadline April 2014 biologicals Clive Roper Charles River Laboratories, United Early Registration Deadline May 2014 a. Pathway-based assays Kingdom 9th World Congress on 24–28 August 2014 b. Alternative disease models Harald Schlatter P&G, Germany Alternatives & Animal Use in c. Screening strategies Gilbert Schönfelder ZEBET, Germany the Life Sciences d. Potency of human and veterinarian vaccines Carl Westmoreland Unilever, United Kingdom Maurice Whelan EURL ECVAM, JRC, Italy Social Programme 6. Human relevance (in vivo, in vitro) Sunday, 24 August 2014 a. Stem cells (screening) Local Organizing Committee Get-Together Party at Hotel Hilton Prague b. Disease models Dagmar Jírová National Institute of Public Health, included in the registration fee c. Human biomarkers Czech Republic d. IVIVE Miroslav Červinka Faculty of Medicine, Charles Monday, 25 August 2014 e. ADME University, Czech Republic Welcome Reception at Public Spa f. Challenges in translational biology Barbora Večlová Freedom for Animals, Czech Republic included in the registration fee g. Pros and cons of animal models (plenary) Lukáš Jebavý Society for Science on Laboratory Animals, FELASA, Czech Republic Wednesday, 27 August 2014 7. Ethics Rostislav Čihák Center of Ecology, Toxicology and Gala Dinner at Municipal House a. Use of materials of human origin Analytics, VUOS, Czech Republic b. Testing in human volunteers Helena Kanďárová MatTek In Vitro Life Science For more information on the scientifi c programme, c. Distress evaluation Laboratories, Slovak Republic abstract submission, registration, hotel reservation d. Benefi t evaluation Kristina Kejlová National Institute of Public Health, and social programme please visit our website: www. e. Transgenics Czech Republic wc9prague.org.
ACPD2014_inz174x272.indd 1 1.7.13 20:55 Im p r i n t
A journal for new paths ALTEX in biomedical science http://www.altex-edition.org http://altweb.jhsph.edu/altex Vol. 30 (Issue 4/2013)
Official organ of: ASCCT, American Society for Cellular and Computational Toxicology, Fairfax, VA, USA; CAAT, Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, MD, USA; CAAT-Europe, University of Konstanz, Konstanz, Germany; Doerenkamp-Zbinden Chairs in Germany, India, The Netherlands, Switzerland and USA; ecopa, European consensus-platform for alternatives, Brussels, Belgium; EUSAAT, European Society for Alternatives to Animal Testing, Vienna, Austria; t4 – transatlantic think tank for toxicology, Baltimore, USA, Konstanz, Germany, Utrecht, The Netherlands
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