An Independent supplement by medIAplAnet to usA todAy A promising era: A myriad of new advancements the state of your emotion: Realities in blood cancer prostate of a caregiver research

December 2012 BEATING CANCER

DID YOU KNOW 10% MORE PEOPLE SURVIVE CANCER EACH YEAR

Giuliana Rancic tells a new story of survivorship TACKLING THE ODDS NFL Linebacker Mark Herzlich has faced his biggest opponent off the field. left photo: timothy White of e! entertainment; right photo: evan pinkus 2 · deCembeR 2012 An independent supplement by mediAplAnet to usA todAy CHALLENGES

Every year, physician researchers are making substantial strides against cancer, progress We reCommend Research that helps people with cancer today as well those who will face the disease in the future. A new world of cancer treatment Building bridges to the future pAGe 10

he American Society of Clini- drives life-saving cancer treat- Sandra M. bridges that will improve care for cal Oncology’s recent report, ment: Clinical cancer research. Swain, MD, all patients around the world. T president, Clinical Cancer Advances 2012, american society Beating CanCer included many inspiring advances. Clinical trials of Clinical Dedication 6th edition, deCemBer 2012 oncology People with cancer today are living Thanks to remarkable advances in It takes years of research effort to Publishers: shannon pandaliano longer, better lives. Since the 1990s, our knowledge of the genes, pro- achieve each significant advance [email protected], cancer death rates have declined teins and other unique molecular in patient care. This progress megan Brunhofer [email protected] 21 percent among men and 12 characteristics that drive each neW therapies would not be possible without Business Developer: Becky Weinstein percent among women, reversing person’s cancer, we are entering a patient volunteers, dedicated [email protected] Designer: daniel mckernan decades of increases. new era of hope for patients. Clini- two new therapies that investigators, and substantial Managing Director: luciana Colapinto Two of three people in the cal trials are the key to translating delay progression of public and private research invest- [email protected] advanced breast cancer: one Editorial Manager: sara Quigley live at least five cutting-edge laboratory discover- ment. In the United States, the fed- [email protected] study found adding targeted years after a cancer diagnosis ies into treatments that extend erally funded clinical trials system therapy to hormonal therapy Contributors: the american Cancer (up from roughly one of two in and improve patients’ lives. delays disease progression in is essential to progress against society, aleen fitzgerald, andrea greif, the 1970s). People with cancer are Tragically, cancer still kills more cancer. Despite difficult economic robert Wechsler-reya, sandra swain, postmenopausal women with halle Bishop Weston, dan Zenka, increasingly able to continue to than 500,000 people in the United advanced hormone receptor- times, preserving our nation’s oncolink.org work and live active lives because States every year, and its global bur- investment in cancer research is positive breast cancer. Distributed within: of treatments with fewer adverse den is growing rapidly. To conquer Another advance was an absolutely necessary to keep the usa today, december 2012 effects and better management cancer, we need to build bridges to armed antibody or “smart momentum that brings better this section was created by mediaplanet and did not involve usa of symptoms. the future—bridges that will get bomb” approach called treatments to the growing num- today or its editorial departments. These dramatic trends—and the scientific advances to the patient’s tdm-1 to selectively deliver ber of people with cancer. medicine to HeR2-positive mediaplanet’s business is to create new advances highlighted in ASCO’s bedside quicker, bridges that will customers for our advertisers by providing breast cancer cells, leaving report—would have been unthink- enable us to share information and Sandra M. Swain, Md readers with high-quality editorial content healthy cells alone. that motivates them to act. able without the engine that learn what works in real time, and [email protected]

your cancer is unique. With GeneKey’s genomic analysis and interdisciplinary team of scientists, your treatment can be too. our mission is to provide therapies that are the national pancreatic Cancer Foundation strives to more effective, less toxic and more cost effec- provide quality of life, sustainability, and dignity to those support. Information. Financial Assistance. fighting pancreatic cancer. CAnCeRCARe Can Help. Informing treatment decisions. tive than current cancer therapeutics. Identifying new options. 1-800-813-Hope www.pancreaticcancerfoundation.com www.cancercare.org www.genekey.com www.tacticaltherapeutics.com

4 · deCembeR 2012 An Independent supplement by medIAplAnet to usA todAy INSPIRATION On November 21st, 2009, NFL linebacker Mark Herzlich’s doctor told him he could probably start to run again, when he felt up to it. For six months of his life, Herzlich battled his biggest opponent yet: Ewing’s Sarcoma. were beyond warranted, and Her- best friend Zack Migeot, and began Overcoming the odds Tackling Cancer zlich wasn’t prepared to sit back searching for other options from Today, not only has Herzlich and watch his dreams slip away top doctors in the country. regained his ability to run, but he he diagnosis came during pain he was experiencing was due right before him. is living out his childhood dream TMark Herzlich’s junior year to Ewing’s Sarcoma, a bone cancer Like anyone who grew up with Faced with a decision of playing in the NFL, as linebacker at Boston College, where he had so rare that little data is available a strong support system of family His own doctor brought up the for the New York Giants. “When earned the status of ACC Defensive for doctors to go by, and which is and friends, Herzlich mustered option of radiation, which would ESPN says you’re going to the NFL, Player of the Year and All American usually treated by removing the strength from his allow Herzlich to keep his femur. that’s when you start to believe it,” player. tumor. loving parents, “Zero doctors that we spoke to said the linebacker recalls. For Herzlich, “I was home playing squash brother radiation. They wouldn’t even per- nothing was going to get between with my mom and I felt this sharp Hit with hard news Brad, and form it,” Herzlich remembers. himself and that belief. pain in my knee,” Herzlich says of Herzlich recalls his doctor telling “Set a goal of what you want to his first symptoms. “We thought it him the surgery would damage his do post-cancer,” Herzlich advises was residual from the season.” leg so badly the he wouldn’t be able those newly diagnosed with can- Upon returning to practice how- to run again. Questions like, “Am cer. “Don’t lose sight of that goal.” ever, the pain began affecting his I going to die? Am I ever going to With his own post-cancer goals in running, his speed and his lifting— play football again?” ran through mind, Herzlich—with the support all skills he would need to carry out the football player’s mind. As an of his parents and oncologist— his dream of making it to the NFL. athlete who ESPN predicted would made the decision to move ahead aleen fitzgerald An MRI finally confirmed that the make it to the NFL, these questions with the radiation. [email protected] photo: evan pinkus WWW p hoto: vidual who was not only concerned .fsimonetti. The unbeatable strength of family about his own welfare but wanted hat does someone say to a sis that could either paralyze a family have done just that for our world. to improve the lives and outcomes

mother whose two children and their spirits or fuel them to move Kaitlyn, Ann’s daughter, knowing C of other patients affected by cancer.” W om and their father have all been diag- forward with tenacity and advocate she too carries this genetic disorder, Sharing a quote from the movie Glad- nosed with cancer over the past 20 to help others. The latter is the route lives daily knowing more than a 21 iator that touched Gregory deeply years? Nothing needs to be said to her they chose without even considering year old needs to know about mortal- is one way they express their son’s ears, as she never asks for anything the former. ity. She welcomes each day as a gift, as her brother was, at the Moffitt spirit, “What we do in life echoes in but the public understanding of how The story and its particulars are living responsibly and respectfully Cancer Institute in Tampa Florida eternity.” Those eight words clearly important research and develop- lengthy but the message is simple managing a healthy lifestyle. “I’m where a current campaign is under- sum up the life of a young man who ment is for the future of others. and powerful: research saves lives grateful to be alive, and appreciate way to provide watchful physician’s asked of society to remember the In 1999 Ann Weber Lang learned and those who have died after fight- even life’s smallest things. When I eyes focused on highly vulnerable importance of helping others by sup- that both of her children were carriers ing cancer have helped the future for get discouraged, I think of Gregory patients for cancer diagnosis: Total porting cancer research for future of a rare genetic disorder giving them cancer treatment by sharing their and everything he went through. Cancer Care. treatments and cures. It’s how the a greater chance of being diagnosed courageous battles of treatment. If he were here, he’d remind me how “Dr. David Shibata of Moffitt Cancer Lang family keeps Gregory’s spirit with cancer, predisposing them to Ann’s late husband Greg and her late much he’d give for even one more Center is a fan of Gregory’s. “Gregory alive and healthy. lives of uncertainty. It was a diagno- son Gregory are two of many who day.” Kaitlyn is currently a patient, is an example of a very special indi- [email protected]

6 · deCembeR 2012 An Independent supplement by medIAplAnet to usA todAy INSIGHT THERE ARE AN ESTIMATED Q&a With GIULIANA RANCIC, tV peRsonAlIty And bReAst CAnCeR suRVIVoR don’t miss! 11 MILLION CANCER SURVIVORS ■■ How has being a breast can- tion. I designed a necklace for sharing my journey helped even LIVING IN THE U.S. cer survivor aided in your new LOFT recently that raised 3 mil- one person, than it was all worth it. TODAY challenge of motherhood? lion dollars for the foundation, I am always so incredibly touched ■■ Breast cancer was one of the an accomplishment that made when a women comes up to me most difficult challenges I have me incredibly proud. I also work and tells me that she got her first was a success and the boy is do- ever been through. Motherhood closely with Bright Pink which is mammogram because of me or ing well today. on the other hand, is the best a non-profit organization based in that she found her breast cancer Her story illustrates the serious thing that has ever happened to . Their mission is to spread early because of my story. commitment that comes with me. When I am holding Duke awareness and share the impor- registering as a potential marrow in my arms, nothing else in the tance of early detection. I was very ■■ What advice can you give to donor. While some volunteers are world matters. Ever since my fortunate to have found my breast newly diagnosed women? after eight years of patience quickly matched with patients in diagnosis, I promised myself to cancer early and have made it my ■■ Attitude is everything. Of and commitment, Erin need, others may wait years. live each day to the fullest and mission to encourage all women to course, our natural first reactions Wright saved the life of a young boy with leukemia. not take one day for granted and be proactive about their health. I’m are sadness, fear and anger, but it Donor diversity that’s what I am trying to do each also excited to be launching Fab- is so important to get yourself to a photo: ©national marroW donor program While most people age 18 to 60 are and every day. U-Wish soon, a program to grant positive space because that is what A wish to save a life eligible to join the Be The Match celebrity and fashion inspired will get you through. A positive On Erin Wright’s fifteenth birth- Registry and become donors, ■■ How have you supported wishes to women battling breast attitude is a very powerful thing. day, she wished she could donate adding more young, diverse po- cancer research since you beat and ovarian cancer. marrow to a stranger—a wish tential donors is critical to in- your cancer? ■■ In what way has beating can- that took more than a decade to creasing the likelihood of trans- ■■ Since my diagnosis, I have ■■ In what ways has being in the cer changed you? come true. plant success. worked closely with BCRF, the public eye shaped your battle ■■ As I said before, I now try to Determined to help others sur- breast cancer research founda- with cancer and your triumph? just live each day to the fullest and vive, Wright registered to become Volunteers save lives ■■ When I was first diagnosed, I focus on the important things in a donor when she turned 18. Beyond registering to become a wasn’t sure if I wanted to go public life. I have an amazing husband donor, those interested in help- with it. But after a few days, I real- and beautiful baby boy, great fam- Worth the wait ing save lives can volunteer their ized that I have an incredible plat- ily and friends and the career of my Eight years later, Erin learned she time, contribute money or sim- form on E! News, , dreams. I’m happy and healthy was a match for a young boy who ply spread the word. Giuliana & Bill and my social net- and looking forward to the future. had leukemia and needed a mar- regan Hall reinertH work sites to share my story to try row transplant. The procedure [email protected] to help people. I realized that if by [email protected]

photo: timothy White of e! entertainment An independent supplement by mediAplAnet to usA todAy deCembeR 2012 · 7 NEWS 80% MORE PEOPLE helping Children & parents RETURN TO WORK AFTER A making brain tumors CANCER DIAGNOSIS light up in the o.R. may prove to be a newtreatment option

atients with glioblastoma, ogy, called 5-ALA tumor fluo- said Dr. Michael Vogelbaum, Pthe most malignant form rescence, is available only in neurosurgeon at The Cleveland of brain cancer, are seeking clinical trials, which are being Clinic The Rose Ella Burkhardt new treatment options every conducted at a small number of Brain Tumor & Neuro-Oncology day. Once a disease with no hospitals in the US. Center. “Removal of as much of About 12,060 children in the United States hope, there currently are more The 5-ALA trial works like the tumor as possible is espe- under the age of 15 will be diagnosed with innovative trials available this: The patient drinks a liquid cially important because most to patients then in any past containing 5-ALA before going glioblastomas re-grow at the cancer in 2012 . decade. into the O.R. The 5-ALA mole- edges of the surgical cavity. The first step in treating a cules are absorbed and circulate The hope is with more tumor Imagine learning that your malignant brain tumor is to throughout the body and brain. cells removed, you reduce the child has cancer. sadly, ■■ “We were once a two- remove as much as the tumor Brain cancer cells convert the chances of the tumor re-grow- this horrible dream comes true income family, but when mass as is possible, without 5-ALA into another molecule ing.” for many families. Imagine the Christopher was diagnosed, producing neurological com- that “lights up” when exposed Cleveland Clinic is one of the shock, denial, fear, despair and my wife stopped working to plications. While there are to blue light. The neurosurgeon few hospitals in the U.S. that myriad of other emotions. the spend every minute with him multiple tools available to help can then see where the 5-ALA has a clinical trial open for medical information is over- in the hospital assuring he guide surgeons in a manner has been converted into the evaluating the use of 5-ALA for whelming and care of the sick gets the care he needs. We similar to a navigation sys- fluorescent molecule. brain tumor patients who have child is necessary. next comes are so grateful to have orga- tem in a car, there has been a “When you look at the surgi- a glioblastomas. the reality check: Work obliga- nizations that we can turn to method to visually distinguish cal field under blue light, the tions, financial obligations, caring when the financial burdens tumor tissue from surrounding normal brain is blue and the for our other children? Who can of cancer start building up.” normal brain, and often they tumor cells are fluorescent we turn to for help? can have a similar appearance. pink. This allows us to find and Halle BiSHOP weStOn A new experimental technol- remove more of the tumor cells,” [email protected] SOUrCe: aMeriCan CanCer SOCietY 8 · deCembeR 2012 An Independent supplement by medIAplAnet to usA todAy INSIGHT getty p hoto: hoto:

A promising era for images prostate cancer patients joe torre’s viCtory off the field s a metastatic prostate Looking to the future Acancer patient and blog- Coupled with our knowledge nown as the fearless man- indeed have prostate cancer.” ger at My New York Minute, I that there are 27 varieties or Kager of the new york yan- Having been diagnosed with frequently tell fellow patients genotypes of prostate cancer kees, who led the team out of an an aggressive form of prostate that there is no better time to and a growing understand- 18-year hiatus to win 4 titles in 5 cancer, torre was faced with a be a prostate cancer patient ing of their biological mecha- years, Joe torre is no stranger to difficult decision. p“ rostate can- than today. This thought is nisms, these new drugs, either overcoming the odds and com- cer is, at first, a little complicated formed from my unique posi- alone or in combination, point ing out on top. but perhaps his because you have to choose tion at the Prostate Cancer towards a day of precision hardest-fought victory is one your course of action,” explains Foundation, where I was medicine for patients. For that occurred off of the baseball torre. “And it just changes your working when I received my those patients diagnosed with field. life.” diagnosis in 2010. low-grade prostate cancer In 1999, torre reported for an With the advice of his doctors, (often non-life-threatening annual stress test. during this torre elected to have surgery— Discovery and Gleason 6), the National Pro- routine check-up, torre’s car- a nerve-sparing prostatectomy development active Surveillance Network diologist detected an elevated —which was a success. From where I sit, I have a bird’s offers possible alternatives to psA level. psA is a protein two months after defeating eye view of the global prostate more aggressive treatments. that is produced by the cells of cancer, torre was back in the Dan Zenka the prostate gland and is often dugout, leading the new york cancer research enterprise senior Vice president, Communications, The future for prostate can- and what some of the world’s prostate Cancer Foundation cer patients continues to grow an indicator of the presence of yankees to their 3rd World brightest researchers are brighter. prostate cancer. At his cardiolo- series under his management. doing to the accelerate the ease who have become resis- For more information gist’s urging, torre had his psA now, twelve years later, he is pace of discovery and devel- tant to hormone therapy and on treatment options and score checked a few weeks still healthy, cancer-free, and as opment of new treatments, fail chemotherapy. Recently, research progress, visit the later. the results revealed that mlb’s Vice president of opera- biomarkers and imaging tech- Zytiga was given FDA approval Prostate Cancer Foundations’ the psA level had risen and this tions, he has no intentions on nologies. Many are already for use earlier in the treatment website at www.pcf.org. spurred a series of tests to deter- retiring any time soon. improving patient outcomes process, prior to chemo, less mine if torre did, in fact, have “by paying attention to your and, in many cases, making than two years after its initial cancer. health, you can continue living prostate cancer a more man- approval in 2011. Other drugs, “I think this is when, even for a very productive, normal life - ageable disease, prolonging such as recently approved a positive person like I try to be, even if you’ve had prostate can- life and eliminating pain and Xtandi, is also in clinical tri- it was tough to think positively,” cer or are living with prostate suffering for many patients. als for earlier use in patients. reflectst orre. “the biopsies, fol- cancer.” Five new drugs have been There are also seven drugs in lowed by the waiting, and then approved for patients in the Phase III trials and another dan zenKa the results came back that I did MaVen BrOwning past years, giving hope to 90+ in Phase I/II trials. [email protected] [email protected] patients with advanced dis-

10 · deCembeR 2012 An independent supplement by mediAplAnet to usA todAy INSIGHT bEtWEEN 2000 aNd 2050 thE NuMbER Of Cancer Research: CaNCER suRvIvORs OvER thE agE Of 65 Urgent & Critical Is ExpECtEd tO Groundbreaking dOubLE immunotherapy shows ■■ What inspired you to equipped to offer “smart bomb”- pursue cancer research? type therapies that specifically promise for blood cancer ■■ I was initially driven by target the cancer cells in a curiosity. but it wasn’t until I person’s own unique tumor, to test thousands of potential patients and others was introduced to a young boy leaving healthy cells alone. therapies to see which ones with a brain tumor that I realized might best benefit that specific how critical our work was. He patient. that requires robotic, Earlier this month, at patients. the adult patients also taught me how urgent it is high-throughput screening the annual American treated had chronic lym- for us to make progress. ever technology. Society of Hematology phocytic leukemia, while since then, that’s been a major conference in Atlanta, two children, including a 7- motivating force in my research. ■■ What would you do with researchers from the year-old girl from western the curiosity is still there, but the an extra $1 million for University of Pennsylva- pennsylvania, had acute kids are what make me get out research? nia and Children’s Hos- lymphocytic leukemia. the of bed in the morning and work ■■ philanthropy is critically pital of Pennsylvania, 7-year-old is among those late into the night. important. If we had more presented findings from who remain in remission fol- money for research, we’d be a clinical trial in which lowing the treatment. ■■ What cancer treatments able to make personalized nine of twelve leukemia are on the horizon? medicine a reality. patients who received the breakthrough therapy ■■ Historically, people have photo: sanford-Burnham mediCal infusions of their own was advanced with funding thought of cancers as diseases researCh institute Robert Wechsler-Reya, genetically engineered from the leukemia & lym- of individual organs—seeing ■■ How can we figure out Ph.D., is a professor and T cells responded to phoma society, the Alliance lung cancer as a different what treatments work for program director in the the therapy and are now for Cancer Gene therapy disease from brain cancer, for one patient differently than National Cancer Institute- cancer-free. and the national Institutes example. but we’re becoming another? designated Cancer Center of Health. aware that cancers in different ■■ simply knowing the list of at Sanford-Burnham Medi- White blood cells were organs may share the same mutations in a tumor doesn’t cal Research Institute. He extracted from the patients genetic mutations. so we might mean we know what to do studies medulloblastoma, and then reprogrammed, treat those cancers with the about them. We also need the the most common malig- using a disabled form of same drug, even though they’re ability to test different therapies nant brain cancer in chil- the AIds virus, to specifi- in different organs. We’re also on different tumor types. We dren. cally target the leukemia andrea greif learning that one person’s lung can do this with tumor models, cells. the reengineered tHe leUKeMia & cancer can be very different or “avatars.” In other words, we blood cells were then lYMPHOMa SOCietY from another person’s. We can grow a patient’s tumor in reinfused back into the [email protected] need to first identify the genetic the laboratory in a way that it vulnerabilities of a patient’s behaves like the original tumor. rOBert weCHSler-reYa, PH.d. cancer. then we’ll be better then we can use the avatar [email protected]