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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. THEJOURNAL OF IMMUNOLOGY Volume 148 / Number 4, February 15, 1992 Contents

CELLULAR IMMUNOLOGY

R. M. Johnson, D. W. Lancki. 983 A Murine CD4-, CD8- T Cell Receptor-y6 T Lymphocyte Clone Specific for A. I. Sperling. R. Dick, P. G. Herpes Simplex Virus Glycoprotein I Spear, F. W. Fitch, and J. A. Bluestone T. Kaisho, T.Nagasawa. T. 989 A Stromal Cell-Specific Monoclonal Antibody Augments the Stromal Cell- Kishimoto. and H. Kikutani Dependent B Lymphopoiesis D. Mpez, S. Rojo, V. Calvo, and 996 Peptide-Presenting Similarities among Functionally Distant HLA-B27 Sub- J. A. Mpez de Castro types Revealed by Alloreactive T Lymphocytes of Unusual Specificity I. F. Luescher. J. A. Lopez, B. 1003 Interaction of Antigenic Peptides with MHC Class I Molecules on Living Malissen, and J.-C. Cerottini Cells Studied by Photoaffinity Labeling M. Merkenschlager and A. G. 1012 Human Postnatal Thymocytes Generate Phenotypically Immature CD3d'm, Fisher CD5d'm,CD1abdght Progeny in Organ Culture M. T. Michalek. B. Benacerraf. 1016 The Class I1 MHC-Restricted Presentation of Endogenously Synthesized and K. L. Rock Ovalbumin Displays Clonal Variation, Requires Endosomal/Lysosomal Downloaded from Processing, and Is Up-Regulated by Heat Shock N. Ramesh. F. Spertini. P. 1025 A Toxic Shock Syndrome Toxin-1 Peptide that Shows Homology to Myco- Scholl. and R. Geha bacterial Heat Shock Protein 18 Is Presented as Conventional Antigen to T Cells by Multiple HLA-DR Alleles M. Riicken. J.-H. Saurat, andC. 1031 A Common Precursor for CD4+T Cells Producing IL-2 or IL-4 Hauser http://www.jimmunol.org/ J. Sen, P. Bossu, S. J. Burakoff, 1037 T Cell Surface Molecules Regulating Noncognate B Lymphocyte Activation: and A. K. Abbas Role of CD2 and LFA-1 W. C. A. Van Schooten. T. Ma- 1043 Purified HLA Class I1 Peptide Complexes Can Induce Adherence and Acti- iore, K. R. Jones, and L. Pa- vation of Peptide-Specific Human T Cell Clones borsky

CLINICALIMMUNOLOGY IMMUNOPATHOLOGY by guest on September 25, 2021

D. K. Bishop and W. Li 1049 Cyclosporin A and FK506 Mediate Differential Effects on T Cell Activation in Vivo R. C. Budd, J. 9. Russell, N. van 1055 CD2 ExpressionCorrelates with Proliferative Capacity of a@+ or y6+ Houten, S. M. Cooper, H. Ya- CD4-CD8- T Cells in Zpr Mice gita, and J. Wolfe R. Carlsson. C. Mirtensson, S. 1065 Human Peripheral Blood Lymphocytes Transplanted into SCIDMice Con- Kalliomiiki, M. Ohlin. and C. stitute an in Vivo Culture System Exhibiting Several Parameters Found A. K. Borrebaeck in aNormal Humoral Immune Responseand Are a Source of Immunocytes for the Production of Human Monoclonal Antibodies C. Cowing and G. L. Gilmore 1072 Allogeneic Chimerism in scid Mice after Neonatal Transfer of Bone Marrow M. K. Robinson, D. Andrew, H. 1080 Antibody against the Leu-CAM @-Chain(CDl8) Promotes Both LFA- 1- and Rosen. D. Brown, S. Ortlepp. CR3-Dependent Adhesion Events P. Stephens, and E. C. Butcher R. P. Schleimer. S. A. Sterbin- 1086 IL-4 Induces Adherence of Human Eosinophils and Basophils but not Neu- sky, J. Kaiser, C. A. Bickel, trophils to Endothelium:Association with Expression of VCAM- 1 D. A. Klunk, K. Tomioka. W. Newman. F. W. Luscinskas, M. A. Gimbrone. Jr.. B. W. McIntyre, and B. S. Bochner

Continued on page 5

THE JOURNAL OF IMMUNOLOGY (ISSN 0022-1767) is published twice each month by The American Association of Immunologists. 428 East Preston Street, Baltimore, MD 21202. Subscription rates $170 ($260 foreign): institutions $300 ($390 foreign): single copy $10 ($15 foreign). Indexed by CurrentContents and IndexMedicus. Secondclass postage paid at Baltimore. MD 21202and at additional mailing offices. POSTMASTER: Send address changesto The Journal of Immunology at 428 East Preston Street,Baltimore. MD 21202. Copyright (c) 1992 by The American Association of Immunologists. Continuedfrom page 3 C. J. G. M. Vennegoor, E. van 1093 Role of LFA-1 and VLA-4 in the Adhesion of Cloned Normal and LFA-1 de Wiel-vanKemenade, R. J. (CDll/CD18)-DeficientT Cells to Cultured Endothelial Cells: Indication F. Huijbens. F. Sanchez-Mad- for a New Adhesion Pathway rid, C. J. M. Melief. and C. G. Figdor

CYTOKINES 0 MEDIATORS 0 REGULATORY MOLECULES

A. Celada and R. A. Maki 1102 Transforming Growth Factor-8 Enhances the M-CSF and GM-CSF-Stimu- lated Proliferation of Macrophages Y.-H. Chin, J.-P. Cai, and X.”. 1106 Transforming Growth Factor-81 and IL-4 Regulate the Adhesiveness of xu Peyer’s PatchHigh Endothelial Venule Cells for Lymphocytes M. F. Gruber, D. S. A. Webb, 1113 Stimulation of Human Monocytes via CD45, CD44, and LFA-3 Triggers and T. L. Gerrard Macrophage-Colony-Stimulating Factor Production: Synergism with Li- popolysaccharide and IL- 18 M. A. Jagels and T. E. Hugli 11 19 Neutrophil Chemotactic Factors Promote Leukocytosis: A Common Mecha- nism forCellular Recruitment from Bone Marrow R. A. Mufson, J. Szabo, and D. 1129 Human IL-3 Induction of c-jun in NormalMonocytes Is Independent of Downloaded from Eckert Tyrosine Kinaseand Involves Protein Kinase C C. M. Roifman. G. Wang, M. 1 136 IL-7 Receptor Mediates Tyrosine Phosphorylation butDoes not Activate the Freedman. and 2. Pan Phosphatidylinositol-Phospholipase C-y 1 Pathway K. Taga and G. Tosato 1143 IL-10 Inhibits Human T-cell Proliferation and IL-2 Production http://www.jimmunol.org/ IMMUNOCHEMISTRY

M. S. Co, N. M. Avdalovic. P. C. 1149 Chimeric and Humanized Antibodies with Specificity for the CD33 Antigen Caron. M. V. Avdalovic, D. A. Scheinberg, and C. Queen W. H. Hildebrand. J. A. Madri- 1155 HLA-Bw22: A Family of Molecules with Identity to HLA-B7 in the cY,-Helix gal, A.-M. Little, and P. Par- ham

D. P. Snider1163 Immunizationwith Antigen Bound to Bispecific Antibody Induces Antibody by guest on September 25, 2021 that Is Restricted in Epitope Specificity and Contains Antiidiotype

Y. Buchmiiller-Rouiller. S. 1171 DifferentialEffects of Prostaglandinson Macrophage Activation Induced Betz-Corradin. and J. Mauel by Calcium Ionophore A23 187 or IFN-y

MICROBIAL IMMUNOLOGY

M. J. Carrier, S. N. Chatfield, 1176 Expression of Human IL-18 in Salmonella typhimurium: A Model System G. Dougan, U. T. A. Nowicka. for the Delivery of RecombinantTherapeutic Proteins in Vivo D. O’callaghan. J. E. Bees- ley, S. Milano. E. Cillari, and F. Y. Liew R. Chatelain, K. Varkila, and 1182 IL-4 Induces a Th2 Response in Leishmania major-Infected Mice R. L. Coffman M. Olivier, K. G. Baimbridge,1188 Stimulus-Response Coupling in Monocytes Infected with Leishmania: At- and N. E. Reiner tenuation of Calcium Transients is Related to Defective Agonist-Induced Accumulation of Inositol Phosphates

Continued onpage 7 Continuedfrom page 5 C. M. Rzepczyk, P. A. Csurhes, 1 197 Comparative Study of the T Cell Response toTwo Allelic Forms of a Malarial A. J. Saul, G. L. Jones, S. Vaccine Candidate Protein Dyer, D. Chee. N. Goss. and ~1 0. Irving K. Uyemura. J. Klotz, C. pir- 1205 Microanatomic Clonality of yS T Cells in Human Leishmaniasis Lesions me;, J. Ohmen. X.-H. Wang. C. Ho. W. L. Hoffman, and R. L. Modlin

MOLECULARBIOLOGY MOLECULAR GENETICS

K. M. Cerosaletti, J. G. Wood- 1212 Two Regions of the H-2 Dd Promoter Are Responsive to Dimethylsulfoxide ward, E. M. Lord, and J. G. in Line 1 Cells by a Mechanism Distinct From IFN-y Frelinger M. D'Addario, M. A. Wainberg, 1222 Activation of Cytokine Genes in HIV-1 Infected Myelomonoblastic Cells by and J. Hiscott Phorbol Ester and Tumor Necrosis Factor J. F. George, Jr. and H. W. 1230 Developmental Regulation of D/3 Reading Frame and Junctional Diversity

Schroeder, Jr. in TCell Receptor-@Transcripts from Human Thymus Downloaded from J. Jain, V. E. Valge-Archer. 1240 Analysis of the AP-1 Sites in the IL-2 Promoter and A. Rao C. R. Lassman, S. Matis, B. L. 1251 Plasma Cell-Regulated Polyadenylation atthe Igy2b Secretion-Specific Hall, D. L. Toppmeyer. and Poly(A)Site C. Milcarek J. Lee, W.-J. Kuang, G. C. Rice, 1261 Characterization of Complementary DNA Clones Encoding the Rabbit IL-8

and W. I. Wood Receptor http://www.jimmunol.org/ L. M. Shewey. J. S. Beaty, L. C. 1265 Differential Expression of Related HLA Class I1 DQ@ Genes Caused by Andersen. and G. T. Nepom Nucleotide Variation in TranscriptionalRegulatory Elements R. Watanabe-Fukunaga, C. I. 1274 The cDNA Structure, Expression, and Chromosomal Assignment of the Brannan. N. Itoh. S. Yone- Mouse Fas Antigen hara, N. G. Copeland. N. A. Jenkins, and S. Nagata

TUMORIMMUNOLOGY by guest on September 25, 2021

B. Bottazzi. S. Walter, D. Go- 1280 Monocyte Chemotactic Cytokine Gene Transfer Modulates Macrophage In- voni, F. Colotta. and A. Man- filtration, Growth, and Susceptibility toIL-2 Therapy of a Murine Mela- tovani noma

Letterthe to Editor 1286

Announcement 1286

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