TMED10 Polyclonal Antibody Without Affecting Its Epsilon-Secretase Activity

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Lieferung: frei Haus Bestellung auf Rechnung SZABO-SCANDIC Lieferung: € 10,- HandelsgmbH & Co KG Erstbestellung Vorauskassa Quellenstraße 110, A-1100 Wien T. +43(0)1 489 3961-0 Zuschläge F. +43(0)1 489 3961-7 [email protected] • Mindermengenzuschlag www.szabo-scandic.com • Trockeneiszuschlag • Gefahrgutzuschlag linkedin.com/company/szaboscandic • Expressversand facebook.com/szaboscandic TMED10 polyclonal antibody without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset Catalog Number: PAB13236 familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq] Regulatory Status: For research use only (RUO) References: Product Description: Rabbit polyclonal antibody raised 1. TMP21 is a presenilin complex component that against synthetic peptide of TMED10. modulates gamma-secretase but not epsilon-secretase activity. Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai Immunogen: A synthetic peptide corresponding to T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, internal region 18 amino acids of human TMED10. Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Host: Rabbit Westaway D, St George-Hyslop P, Fraser P. Nature. 2006 Apr 27;440(7088):1208-12. Reactivity: Human,Mouse,Rat 2. Functional reconstitution of gamma-secretase through Applications: IHC-P, WB-Ti coordinated expression of presenilin, nicastrin, Aph-1, (See our web site product page for detailed applications and Pen-2. Periz G, Fortini ME. J Neurosci Res. 2004 information) Aug 1;77(3):309-22. 3. Tmp21 and p24A, two type I proteins enriched in Protocols: See our web site at pancreatic microsomal membranes, are members of a http://www.abnova.com/support/protocols.asp or product protein family involved in vesicular trafficking. Blum R, page for detailed protocols Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I. J Biol Chem. 1996 Jul Form: Liquid 19;271(29):17183-9.

Recommend Usage: Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS (0.02% sodium azide)

Storage Instruction: Store at 4°C for three months. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 10972

Gene Symbol: TMED10

Gene Alias: P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I

Gene Summary: This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity

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