MAPK10 monoclonal antibody, member of the MAP family. MAP act as clone 2G12H3 an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such Catalog Number: MAB5533 as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific Regulatory Status: For research use only (RUO) form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase Product Description: Mouse monoclonal antibody plays regulatory roles in the signaling pathways during raised against partial recombinant MAPK10. neuronal . Beta- 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, Clone Name: 2G12H3 and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can Immunogen: Recombinant protein corresponding to phosphorylate, and inhibit the activity of this kinase, human MAPK10. which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants Host: Mouse encoding distinct isoforms have been reported. [provided Reactivity: Human by RefSeq]

Applications: ELISA, WB References: (See our web site product page for detailed applications 1. Role of - and stress-activated kinases in information) ischemic injury. Irving EA, Bamford M. J Cereb Blood Flow Metab. 2002 Jun;22(6):631-47. Protocols: See our web site at 2. Mitogen-activated protein kinase kinase 4 (MKK4). http://www.abnova.com/support/protocols.asp or product Cuenda A. Int J Biochem Cell Biol. 2000 page for detailed protocols Jun;32(6):581-7. 3. The Jnk1 and Jnk2 protein kinases are required for Form: Liquid regional specific apoptosis during early brain development. Kuan CY, Yang DD, Samanta Roy DR, Isotype: IgG1 Davis RJ, Rakic P, Flavell RA. Neuron. 1999 Apr;22(4):667-76. Recommend Usage: Western Blot (1:500-1:1000) ELISA (1:10000) The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)

Storage Instruction: Store at -20°C. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 5602

Gene Symbol: MAPK10

Gene Alias: FLJ12099, FLJ33785, JNK3, JNK3A, MGC50974, PRKM10, p493F12, p54bSAPK

Gene Summary: The protein encoded by this gene is a

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