Report generated from BNF with QVH Formulary provided by FormularyComplete (www.pharmpress.com). Accessed 09 10 2015

TA Title Formulary Status Section TA Link Annotation Number

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone ABIRATERONE Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and TA259 http://www.nice.org.uk/TA259 Not relevant to QVH. gonadotrophin-releasing hormone antagonists->Anti-

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Abraxane® Non Formulary drugs->Taxanes->PACLITAXEL->Albumin-bound Not relevant to QVH. formulation

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Adcetris® Non Formulary drugs->Brentuximab vedotin->BRENTUXIMAB VEDOTIN

8.2 Drugs affecting the immune response->8.2.2 Adoport® Non Formulary Corticosteroids and other immunosuppressants->TACROLIMUS

8.2 Drugs affecting the immune response->8.2.2 Corticosteroids and other Advagraf® Non Formulary immunosuppressants->TACROLIMUS->Modified release

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic AFATINIB Non Formulary TA310 http://www.nice.org.uk/TA310 Not relevant to QVH drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Afinitor® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->EVEROLIMUS

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Aflibercept Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic AFLIBERCEPT Non Formulary TA307 http://www.nice.org.uk/TA307 Not relevant to QVH drugs->Aflibercept

8.2 Drugs affecting the immune response->8.2.4 Aldesleukin Non Formulary Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 ALDESLEUKIN Non Formulary Other immunomodulating drugs->Aldesleukin 8.2 Drugs affecting the immune response->8.2.3 ALEMTUZUMAB Non Formulary TA312 http://www.nice.org.uk/TA312 Not relevant to QVH. Anti-lymphocyte monoclonal antibodies

8.1 Cytotoxic drugs->8.1.3 Alimta® Non Formulary Not relevant to QVH. Antimetabolites->PEMETREXED

8.1 Cytotoxic drugs->8.1.1 Alkylating Alkeran® Non Formulary drugs->MELPHALAN

8.1 Cytotoxic drugs->Treatment for Anthracycline side-effects Non Formulary cytotoxic-induced side-effects

ANTITHYMOCYTE 8.2 Drugs affecting the immune response->8.2.2 IMMUNOGLOBULIN Non Formulary Corticosteroids and other immunosuppressants (RABBIT)

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Aromasin® Non Formulary antagonists->8.3.4.1 Breast cancer->EXEMESTANE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Arsenic trioxide Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic ARSENIC TRIOXIDE Non Formulary drugs->Arsenic trioxide

8.2 Drugs affecting the immune response->8.2.3 Arzerra® Non Formulary Anti-lymphocyte monoclonal Not relevant to QVH. antibodies->OFATUMUMAB

8.1 Cytotoxic drugs->8.1.3 Atriance® Non Formulary Antimetabolites->NELARABINE

8.2 Drugs affecting the immune response->8.2.4 Aubagio® Non Formulary Other immunomodulating Not relevant to QVH. drugs->Teriflunomide->TERIFLUNOMIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Avastin® Non Formulary Not relevant to QVH for NICE indications. Consultant Ophthalmologist only. drugs->Bevacizumab->BEVACIZUMAB

8.2 Drugs affecting the immune response->8.2.4 Avonex® Non Formulary Other immunomodulating drugs->Interferon beta->INTERFERON BETA->Interferon beta-1a

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic AXITINIB Non Formulary TA333 http://www.nice.org.uk/TA333 Not relevant to QVH drugs->Protein kinase inhibitors

AZACITIDINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA218 http://www.nice.org.uk/TA218 Not relevant to QVH 8.2 Drugs affecting the immune response->8.2.4 BACILLUS Non Formulary Other immunomodulating drugs->BCG bladder CALMETTE-GUÉRIN instillation

8.2 Drugs affecting the immune response->8.2.2 BASILIXIMAB Non Formulary Not relevant to QVH. Corticosteroids and other immunosuppressants

8.2 Drugs affecting the immune response->8.2.4 BCG bladder instillation Non Formulary Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.2 BELATACEPT Non Formulary Corticosteroids and other immunosuppressants

BENDAMUSTINE Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs TA216 http://www.nice.org.uk/TA216 Not relevant to QVH. HYDROCHLORIDE

8.2 Drugs affecting the immune response->8.2.4 Betaferon® Non Formulary Other immunomodulating drugs->Interferon beta->INTERFERON BETA->Interferon beta-1b

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Bevacizumab Non Formulary Not relevant to QVH for NICE indications. Consultant Ophthalmologist only. drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEVACIZUMAB Non Formulary TA212 http://www.nice.org.uk/TA212 Not relevant to QVH for NICE indications. Consultant ophthalmologist only. drugs->Bevacizumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEVACIZUMAB Non Formulary TA178 http://www.nice.org.uk/TA178 Not relevant to QVH for NICE indications. Consultant ophthalmologist only. drugs->Bevacizumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEVACIZUMAB Non Formulary TA118 http://www.nice.org.uk/TA118 Not relevant to QVH for NICE indications. Consultant ophthalmologist only. drugs->Bevacizumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEVACIZUMAB Non Formulary TA242 http://www.nice.org.uk/TA242 Not relevant to QVH for NICE indications. Consultant ophthalmologist only. drugs->Bevacizumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEVACIZUMAB Non Formulary TA263 http://www.nice.org.uk/TA263 Not relevant to QVH for NICE indications. Consultant ophthalmologist only. drugs->Bevacizumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEVACIZUMAB Non Formulary TA284 http://www.nice.org.uk/TA284 Not relevant to QVH for NICE indications. Consultant ophthalmologist only. drugs->Bevacizumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEVACIZUMAB Non Formulary TA214 http://www.nice.org.uk/TA214 Not relevant to QVH for NICE indications. Consultant ophthalmologist only. drugs->Bevacizumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEVACIZUMAB Non Formulary TA285 http://www.nice.org.uk/TA285 Not relevant to QVH for NICE indications. Consultant ophthalmologist only. drugs->Bevacizumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Bexarotene Non Formulary drugs 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BEXAROTENE Non Formulary drugs->Bexarotene

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and BLEOMYCIN Non Formulary other cytotoxic antibiotics

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Bleomycin Non Formulary other cytotoxic antibiotics->BLEOMYCIN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Bortezomib Non Formulary Not relevant to QVH drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BORTEZOMIB Non Formulary TA129 http://www.nice.org.uk/TA129 Not relevant to QVH. drugs->Bortezomib

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BORTEZOMIB Non Formulary TA228 http://www.nice.org.uk/TA228 Not relevant to QVH. drugs->Bortezomib

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BORTEZOMIB Non Formulary TA311 http://www.nice.org.uk/TA311 Not relevant to QVH. drugs->Bortezomib

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Bosulif® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->BOSUTINIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BOSUTINIB Non Formulary TA299 http://www.nice.org.uk/TA299 Not relevant to QVH drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Brentuximab vedotin Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic BRENTUXIMAB VEDOTIN Non Formulary drugs->Brentuximab vedotin

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Gonadorelin analogues

8.1 Cytotoxic drugs->8.1.1 Alkylating Busilvex® Non Formulary drugs->BUSULFAN

BUSULFAN Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CABAZITAXEL Non Formulary TA255 http://www.nice.org.uk/TA255 Not relevant to QVH. drugs->Taxanes

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CABOZANTINIB Non Formulary drugs->Protein kinase inhibitors 8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Caelyx® Non Formulary other cytotoxic antibiotics->DOXORUBICIN HYDROCHLORIDE->Lipid formulation

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Calcium folinate Non Formulary Not relevant to QVH. side-effects->Chemotherapy-induced mucositis and myelosuppression->FOLINIC ACID

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Calcium Folinate Non Formulary side-effects->Chemotherapy-induced mucositis Not relevant to QVH. and myelosuppression->FOLINIC ACID->Calcium folinate

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Calcium levofolinate Non Formulary side-effects->Chemotherapy-induced mucositis and myelosuppression->LEVOFOLINIC ACID

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Calcium Levofolinate Non Formulary side-effects->Chemotherapy-induced mucositis and myelosuppression->LEVOFOLINIC ACID->Calcium levofolinate

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Campto® Non Formulary drugs->Topoisomerase I inhibitors->IRINOTECAN Not relevant to QVH. HYDROCHLORIDE

8.2 Drugs affecting the immune response->8.2.4 Canakinumab Non Formulary Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 CANAKINUMAB Non Formulary Other immunomodulating drugs->Canakinumab

CAPECITABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA61 http://www.nice.org.uk/TA61 Not relevant to QVH

CAPECITABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA263 http://www.nice.org.uk/TA263 Not relevant to QVH

CAPECITABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA212 http://www.nice.org.uk/TA212 Not relevant to QVH

CAPECITABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA191 http://www.nice.org.uk/TA191 Not relevant to QVH

CAPECITABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA100 http://www.nice.org.uk/TA100 Not relevant to QVH

8.1 Cytotoxic drugs->8.1.3 Capecitabine Non Formulary Not relevant to QVH Antimetabolites->CAPECITABINE 8.2 Drugs affecting the immune response->8.2.2 Capexion® Non Formulary Corticosteroids and other immunosuppressants->TACROLIMUS

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Caprelsa® Non Formulary drugs->Protein kinase inhibitors->VANDETANIB

8.2 Drugs affecting the immune response->8.2.2 Capsorin® Non Formulary Corticosteroids and other immunosuppressants->CICLOSPORIN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CARBOPLATIN Non Formulary Not relevant to QVH drugs->Platinum compounds

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Carboplatin Non Formulary Not relevant to QVH drugs->Platinum compounds->CARBOPLATIN

8.1 Cytotoxic drugs->Treatment for Cardioxane® Non Formulary cytotoxic-induced side-effects->Anthracycline side-effects->DEXRAZOXANE

CARMUSTINE Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs TA121 http://www.nice.org.uk/TA121 Not relevant to QVH.

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Catumaxomab Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CATUMAXOMAB Non Formulary drugs->Catumaxomab

8.2 Drugs affecting the immune response->8.2.4 Other immunomodulating Ceplene® Non Formulary drugs->Histamine->HISTAMINE DIHYDROCHLORIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Cetuximab Non Formulary Not relevant to QVH. drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CETUXIMAB Non Formulary TA172 http://www.nice.org.uk/TA172 Not relevant to QVH. drugs->Cetuximab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CETUXIMAB Non Formulary TA118 http://www.nice.org.uk/TA118 Not relevant to QVH. drugs->Cetuximab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CETUXIMAB Non Formulary TA145 http://www.nice.org.uk/TA145 Not relevant to QVH. drugs->Cetuximab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CETUXIMAB Non Formulary TA176 http://www.nice.org.uk/TA176 Not relevant to QVH. drugs->Cetuximab 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CETUXIMAB Non Formulary TA242 http://www.nice.org.uk/TA242 Not relevant to QVH. drugs->Cetuximab

Chemotherapy-induced 8.1 Cytotoxic drugs->Treatment for mucositis and Non Formulary cytotoxic-induced side-effects myelosuppression

CHLORAMBUCIL Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CISPLATIN Non Formulary drugs->Platinum compounds

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Cisplatin Non Formulary drugs->Platinum compounds->CISPLATIN

CLADRIBINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites

CLOFARABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Cometriq® Non Formulary drugs->Protein kinase inhibitors->CABOZANTINIB

8.2 Drugs affecting the immune response->8.2.4 Copaxone® Non Formulary Other immunomodulating drugs->Glatiramer Not relevant to QVH. acetate->GLATIRAMER ACETATE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Crisantaspase Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CRISANTASPASE Non Formulary drugs->Crisantaspase

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic CRIZOTINIB Non Formulary TA296 http://www.nice.org.uk/TA296 Not relevant to QVH drugs->Protein kinase inhibitors

CYTARABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites

8.1 Cytotoxic drugs->8.1.3 Cytarabine Non Formulary Antimetabolites->CYTARABINE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic DABRAFENIB Non Formulary TA321 http://www.nice.org.uk/TA321 drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic DACARBAZINE Non Formulary Not relevant to QVH. drugs->Dacarbazine and temozolomide

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Dacarbazine Non Formulary drugs->Dacarbazine and Not relevant to QVH. temozolomide->DACARBAZINE Dacarbazine and 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Non Formulary temozolomide drugs

8.1 Cytotoxic drugs->8.1.3 Dacogen® Non Formulary Antimetabolites->DECITABINE

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and DACTINOMYCIN Non Formulary other cytotoxic antibiotics

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Dactinomycin Non Formulary other cytotoxic antibiotics->DACTINOMYCIN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic DASATINIB Non Formulary TA241 http://www.nice.org.uk/TA241 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic DASATINIB Non Formulary TA251 http://www.nice.org.uk/TA251 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and DAUNORUBICIN Non Formulary other cytotoxic antibiotics

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Daunorubicin Non Formulary other cytotoxic antibiotics->DAUNORUBICIN

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Decapeptyl® SR Non Formulary gonadotrophin-releasing hormone antagonists->Gonadorelin analogues->TRIPTORELIN

DECITABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Non Formulary gonadotrophin-releasing hormone antagonists->Gonadotrophin-releasing hormone antagonists

8.1 Cytotoxic drugs->8.1.3 DepoCyte® Non Formulary Antimetabolites->CYTARABINE->Lipid formulation for intrathecal use

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Depot preparation Non Formulary antagonists->8.3.4.3 Somatostatin analogues->OCTREOTIDE 8.2 Drugs affecting the immune response->8.2.2 Initiation on advice of consultant for prevention of acute rejection episodes for ophthalmology. Available as Deximune® Non Formulary Corticosteroids and other 2% eye ointment - UNLICENSED. Consultant dermatologist and rheumatologist. immunosuppressants->CICLOSPORIN

8.1 Cytotoxic drugs->Treatment for DEXRAZOXANE Non Formulary cytotoxic-induced side-effects->Anthracycline side-effects

8.3 Sex hormones and hormone antagonists in Non Formulary malignant disease->8.3.1 Oestrogens

8.3 Sex hormones and hormone antagonists in Diethylstilbestrol Non Formulary malignant disease->8.3.1 Oestrogens->DIETHYLSTILBESTROL

8.2 Drugs affecting the immune response->8.2.4 Dimethyl fumarate Non Formulary Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 DIMETHYL FUMARATE Non Formulary Other immunomodulating drugs->Dimethyl TA320 http://www.nice.org.uk/TA320 Not relevant to QVH. fumarate

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Disodium folinate Non Formulary Not relevant to QVH. side-effects->Chemotherapy-induced mucositis and myelosuppression->FOLINIC ACID

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic DOCETAXEL Non Formulary TA109 http://www.nice.org.uk/TA109 Not relevant to QVH. drugs->Taxanes

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic DOCETAXEL Non Formulary TA101 http://www.nice.org.uk/TA101 Not relevant to QVH. drugs->Taxanes

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Docetaxel Non Formulary Not relevant to QVH. drugs->Taxanes->DOCETAXEL

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Doxorubicin Non Formulary other cytotoxic antibiotics->DOXORUBICIN Not relevant to QVH HYDROCHLORIDE

DOXORUBICIN 8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Non Formulary TA91 http://www.nice.org.uk/TA91 Not relevant to QVH. HYDROCHLORIDE other cytotoxic antibiotics

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Eldisine® Non Formulary etoposide->VINDESINE SULFATE 8.2 Drugs affecting the immune response->8.2.2 Corticosteroids and other Envarsus® Non Formulary immunosuppressants->TACROLIMUS->Modified release

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and TA316 http://www.nice.org.uk/TA316 Not relevant to QVH gonadotrophin-releasing hormone antagonists->Anti-androgens

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Epirubicin Non Formulary other cytotoxic antibiotics->EPIRUBICIN HYDROCHLORIDE

EPIRUBICIN 8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Non Formulary HYDROCHLORIDE other cytotoxic antibiotics

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Erbitux® Non Formulary Not relevant to QVH. drugs->Cetuximab->CETUXIMAB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Eribulin Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic ERIBULIN Non Formulary TA250 http://www.nice.org.uk/TA250 Not relevant to QVH drugs->Eribulin

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Erivedge® Non Formulary drugs->Vismodegib->VISMODEGIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic ERLOTINIB Non Formulary TA258 http://www.nice.org.uk/TA258 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic ERLOTINIB Non Formulary TA162 http://www.nice.org.uk/TA162 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic ERLOTINIB Non Formulary TA227 http://www.nice.org.uk/TA227 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Erwinase® Non Formulary drugs->Crisantaspase->CRISANTASPASE

8.1 Cytotoxic drugs->8.1.1 Alkylating Estracyt® Non Formulary drugs->ESTRAMUSTINE PHOSPHATE

ESTRAMUSTINE Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs PHOSPHATE 8.3 Sex hormones and hormone antagonists in Non Formulary malignant disease->8.3.1 Oestrogens

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Etopophos® Non Formulary etoposide->ETOPOSIDE

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and ETOPOSIDE Non Formulary etoposide

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Etoposide Non Formulary etoposide->ETOPOSIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic EVEROLIMUS Non Formulary TA295 http://www.nice.org.uk/TA295 Not relevant to QVH drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic EVEROLIMUS Non Formulary TA219 http://www.nice.org.uk/TA219 Not relevant to QVH drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.3 Evoltra® Non Formulary Antimetabolites->CLOFARABINE

8.3 Sex hormones and hormone antagonists in EXEMESTANE Non Formulary malignant disease->8.3.4 Hormone TA295 http://www.nice.org.uk/TA295 antagonists->8.3.4.1 Breast cancer

8.2 Drugs affecting the immune response->8.2.4 Extavia® Non Formulary Other immunomodulating drugs->Interferon beta->INTERFERON BETA->Interferon beta-1b

8.3 Sex hormones and hormone antagonists in Fareston® Non Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.1 Breast cancer->TOREMIFENE

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Faslodex® Non Formulary Not relevant to QVH antagonists->8.3.4.1 Breast cancer->FULVESTRANT

8.3 Sex hormones and hormone antagonists in Femara® Non Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.1 Breast cancer->LETROZOLE

8.2 Drugs affecting the immune response->8.2.4 Fingolimod Non Formulary Not relevant to QVH. Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 FINGOLIMOD Non Formulary TA254 http://www.nice.org.uk/TA254 Not relevant to QVH. Other immunomodulating drugs->Fingolimod 8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Firmagon® Non Formulary gonadotrophin-releasing hormone antagonists->Gonadotrophin-releasing hormone antagonists->DEGARELIX

8.1 Cytotoxic drugs->8.1.3 Fludara® Non Formulary Not relevant to QVH. Antimetabolites->FLUDARABINE PHOSPHATE

FLUDARABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA119 http://www.nice.org.uk/TA119 Not relevant to QVH. PHOSPHATE

FLUDARABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA29 http://www.nice.org.uk/TA29 Not relevant to QVH. PHOSPHATE

8.1 Cytotoxic drugs->8.1.3 Fludarabine phosphate Non Formulary Not relevant to QVH. Antimetabolites->FLUDARABINE PHOSPHATE

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Anti-androgens

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Flutamide Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Anti-androgens->FLUTAMIDE

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced FOLINIC ACID Non Formulary TA212 http://www.nice.org.uk/TA212 Not relevant to QVH. side-effects->Chemotherapy-induced mucositis and myelosuppression

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Foscan® Non Formulary drugs->Porfimer sodium and temoporfin->TEMOPORFIN

8.3 Sex hormones and hormone antagonists in FULVESTRANT Non Formulary malignant disease->8.3.4 Hormone Not relevant to QVH antagonists->8.3.4.1 Breast cancer

8.2 Drugs affecting the immune response->8.2.3 Gazyvaro® Non Formulary Anti-lymphocyte monoclonal antibodies->OBINUTUZUMAB 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic GEFITINIB Non Formulary TA192 http://www.nice.org.uk/TA192 Not relevant to QVH. drugs->Protein kinase inhibitors

GEMCITABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA116 http://www.nice.org.uk/TA116 Not relevant to QVH.

GEMCITABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA25 http://www.nice.org.uk/TA25 Not relevant to QVH.

8.1 Cytotoxic drugs->8.1.3 Gemcitabine Non Formulary Not relevant to QVH. Antimetabolites->GEMCITABINE

8.1 Cytotoxic drugs->8.1.3 Gemzar® Non Formulary Not relevant to QVH. Antimetabolites->GEMCITABINE

8.2 Drugs affecting the immune response->8.2.4 Gilenya® Non Formulary Other immunomodulating Not relevant to QVH. drugs->Fingolimod->FINGOLIMOD

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Giotrif® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->AFATINIB

8.2 Drugs affecting the immune response->8.2.4 Glatiramer acetate Non Formulary Not relevant to QVH. Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 GLATIRAMER ACETATE Non Formulary Other immunomodulating drugs->Glatiramer TA32 http://www.nice.org.uk/TA32 Not relevant to QVH. acetate

8.1 Cytotoxic drugs->8.1.1 Alkylating Gliadel® Non Formulary Not relevant to QVH. drugs->CARMUSTINE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Glivec® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->IMATINIB

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Gonapeptyl Depot® Non Formulary gonadotrophin-releasing hormone antagonists->Gonadorelin analogues->TRIPTORELIN

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Gonadorelin analogues

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Halaven® Non Formulary Not relevant to QVH drugs->Eribulin->ERIBULIN 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Herceptin® Non Formulary Not relevant to QVH. drugs->Trastuzumab->TRASTUZUMAB

8.2 Drugs affecting the immune response->8.2.4 Histamine Non Formulary Other immunomodulating drugs

HISTAMINE 8.2 Drugs affecting the immune response->8.2.4 Non Formulary DIHYDROCHLORIDE Other immunomodulating drugs->Histamine

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Hycamtin® Non Formulary Not relevant to QVH. drugs->Topoisomerase I inhibitors->TOPOTECAN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Hydrea® Non Formulary drugs->Hydroxycarbamide->HYDROXYCARBAMIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Hydroxycarbamide Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic HYDROXYCARBAMIDE Non Formulary drugs->Hydroxycarbamide

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Hydroxycarbamide Non Formulary drugs->Hydroxycarbamide->HYDROXYCARBAMIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Iclusig® Non Formulary drugs->Protein kinase inhibitors->PONATINIB

IDARUBICIN 8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Non Formulary HYDROCHLORIDE other cytotoxic antibiotics

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IDELALISIB Non Formulary drugs->Protein kinase inhibitors

IFOSFAMIDE Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs

8.1 Cytotoxic drugs->8.1.1 Alkylating Ifosfamide Non Formulary drugs->IFOSFAMIDE

8.2 Drugs affecting the immune response->8.2.4 Ilaris® Non Formulary Other immunomodulating drugs->Canakinumab->CANAKINUMAB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IMATINIB Non Formulary TA70 http://www.nice.org.uk/TA70 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IMATINIB Non Formulary TA326 http://www.nice.org.uk/TA326 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IMATINIB Non Formulary TA209 http://www.nice.org.uk/TA209 Not relevant to QVH. drugs->Protein kinase inhibitors 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IMATINIB Non Formulary TA241 http://www.nice.org.uk/TA241 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IMATINIB Non Formulary TA251 http://www.nice.org.uk/TA251 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IMATINIB Non Formulary TA86 http://www.nice.org.uk/TA86 Not relevant to QVH. drugs->Protein kinase inhibitors

8.2 Drugs affecting the immune response->8.2.4 ImmuCyst® Non Formulary Other immunomodulating drugs->BCG bladder instillation->BACILLUS CALMETTE-GU�RIN

8.2 Drugs affecting the immune response->8.2.4 Immukin® Non Formulary Other immunomodulating drugs->Interferon gamma->INTERFERON GAMMA-1b

8.2 Drugs affecting the immune response->8.2.4 Imnovid® Non Formulary Other immunomodulating drugs->Lenalidomide, pomalidomide, and thalidomide->POMALIDOMIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Inlyta® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->AXITINIB

8.2 Drugs affecting the immune response->8.2.4 Interferon beta Non Formulary Not relevant to QVH. Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 INTERFERON BETA Non Formulary TA32 http://www.nice.org.uk/TA32 Not relevant to QVH. Other immunomodulating drugs->Interferon beta

8.2 Drugs affecting the immune response->8.2.4 Interferon beta-1a Non Formulary Other immunomodulating drugs->Interferon beta->INTERFERON BETA

8.2 Drugs affecting the immune response->8.2.4 Interferon beta-1b Non Formulary Other immunomodulating drugs->Interferon beta->INTERFERON BETA

8.2 Drugs affecting the immune response->8.2.4 Interferon gamma Non Formulary Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 INTERFERON GAMMA-1b Non Formulary Other immunomodulating drugs->Interferon gamma

8.2 Drugs affecting the immune response->8.2.4 IntronA® Non Formulary Other immunomodulating drugs->Interferon alfa->INTERFERON ALFA 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Ipilimumab Non Formulary Not relevant to QVH. drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IPILIMUMAB Non Formulary TA268 http://www.nice.org.uk/TA268 Not relevant to QVH. drugs->Ipilimumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IPILIMUMAB Non Formulary TA319 http://www.nice.org.uk/TA319 Not relevant to QVH. drugs->Ipilimumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Iressa® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->GEFITINIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Irinotecan Non Formulary drugs->Topoisomerase I inhibitors->IRINOTECAN Not relevant to QVH. HYDROCHLORIDE

IRINOTECAN 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Non Formulary TA307 http://www.nice.org.uk/TA307 Not relevant to QVH. HYDROCHLORIDE drugs->Topoisomerase I inhibitors

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Isovorin® Non Formulary side-effects->Chemotherapy-induced mucositis and myelosuppression->LEVOFOLINIC ACID->Calcium levofolinate

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Jakavi® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->RUXOLITINIB

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Javlor® Non Formulary Not relevant to QVH etoposide->VINFLUNINE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Jevtana® Non Formulary Not relevant to QVH. drugs->Taxanes->CABAZITAXEL

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Kadcyla® Non Formulary drugs->Trastuzumab emtansine->TRASTUZUMAB EMTANSINE

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Kepivance® Non Formulary side-effects->Chemotherapy-induced mucositis and myelosuppression->PALIFERMIN

8.3 Sex hormones and hormone antagonists in LANREOTIDE Non Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.3 Somatostatin analogues

8.1 Cytotoxic drugs->8.1.3 Lanvis® Non Formulary Antimetabolites->TIOGUANINE 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic LAPATINIB Non Formulary TA257 http://www.nice.org.uk/TA257 Not relevant to QVH. drugs->Protein kinase inhibitors

8.2 Drugs affecting the immune response->8.2.3 Lemtrada® Non Formulary Anti-lymphocyte monoclonal Not relevant to QVH antibodies->ALEMTUZUMAB

8.2 Drugs affecting the immune response->8.2.4 LENALIDOMIDE Non Formulary Other immunomodulating drugs->Lenalidomide, TA322 http://www.nice.org.uk/TA322 Not relevant to QVH. pomalidomide, and thalidomide

8.2 Drugs affecting the immune response->8.2.4 LENALIDOMIDE Non Formulary Other immunomodulating drugs->Lenalidomide, TA171 http://www.nice.org.uk/TA171 Not relevant to QVH. pomalidomide, and thalidomide

Lenalidomide, 8.2 Drugs affecting the immune response->8.2.4 pomalidomide, and Non Formulary Not relevant to QVH. Other immunomodulating drugs thalidomide

8.3 Sex hormones and hormone antagonists in LETROZOLE Non Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.1 Breast cancer

8.3 Sex hormones and hormone antagonists in Letrozole Non Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.1 Breast cancer->LETROZOLE

8.1 Cytotoxic drugs->8.1.1 Alkylating Leukeran® Non Formulary drugs->CHLORAMBUCIL

8.1 Cytotoxic drugs->8.1.3 Leustat® Non Formulary Antimetabolites->CLADRIBINE

8.1 Cytotoxic drugs->8.1.1 Alkylating Levact® Non Formulary Not relevant to QVH. drugs->BENDAMUSTINE HYDROCHLORIDE

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced LEVOFOLINIC ACID Non Formulary side-effects->Chemotherapy-induced mucositis and myelosuppression

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Levofolinic Acid Non Formulary side-effects->Chemotherapy-induced mucositis and myelosuppression->LEVOFOLINIC ACID->Disodium levofolinate 8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Lipid formulation Non Formulary other cytotoxic antibiotics->DAUNORUBICIN

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Lipid formulation Non Formulary other cytotoxic antibiotics->DOXORUBICIN Not relevant to QVH HYDROCHLORIDE

Lipid formulation for 8.1 Cytotoxic drugs->8.1.3 Non Formulary intrathecal use Antimetabolites->CYTARABINE

8.1 Cytotoxic drugs->8.1.3 Litak® Non Formulary Antimetabolites->CLADRIBINE

LOMUSTINE Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs

8.1 Cytotoxic drugs->8.1.1 Alkylating Lomustine Non Formulary drugs->LOMUSTINE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Lysodren® Non Formulary drugs->Mitotane->MITOTANE

8.2 Drugs affecting the immune response->8.2.3 MabThera® Non Formulary Anti-lymphocyte monoclonal Not relevant to QVH for these indications. Patients would be referred for this treatment elsewhere antibodies->RITUXIMAB

MEDROXYPROGESTERONE 8.3 Sex hormones and hormone antagonists in Non Formulary ACETATE malignant disease->8.3.2

8.3 Sex hormones and hormone antagonists in Megace® Non Formulary malignant disease->8.3.2 Progestogens->MEGESTROL ACETATE

8.3 Sex hormones and hormone antagonists in Non Formulary malignant disease->8.3.2 Progestogens

MELPHALAN Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs

8.2 Drugs affecting the immune response->8.2.4 Mepact® Non Formulary Other immunomodulating Not relevant to QVH. drugs->Mifamurtide->MIFAMURTIDE

MERCAPTOPURINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites

8.1 Cytotoxic drugs->Treatment for MESNA Non Formulary cytotoxic-induced side-effects->Urothelial toxicity

8.1 Cytotoxic drugs->Treatment for Mesna Non Formulary cytotoxic-induced side-effects->Urothelial toxicity->MESNA 8.2 Drugs affecting the immune response->8.2.4 Mifamurtide Non Formulary Not relevant to QVH. Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 MIFAMURTIDE Non Formulary TA235 http://www.nice.org.uk/TA235 Not relevant to QVH. Other immunomodulating drugs->Mifamurtide

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Mitotane Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic MITOTANE Non Formulary drugs->Mitotane

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and MITOXANTRONE Non Formulary other cytotoxic antibiotics

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Mitoxantrone Non Formulary other cytotoxic antibiotics->MITOXANTRONE

8.2 Drugs affecting the immune response->8.2.2 Modified release Non Formulary Corticosteroids and other immunosuppressants->TACROLIMUS

8.2 Drugs affecting the immune response->8.2.2 Modigraf® Non Formulary Corticosteroids and other immunosuppressants->TACROLIMUS

8.2 Drugs affecting the immune response->8.2.1 Mycophenolic acid Non Formulary Antiproliferative immunosuppressants->MYCOPHENOLATE MOFETIL

8.2 Drugs affecting the immune response->8.2.1 Antiproliferative Myfortic® Non Formulary immunosuppressants->MYCOPHENOLATE MOFETIL->Mycophenolic acid

8.1 Cytotoxic drugs->8.1.1 Alkylating Myleran® Non Formulary drugs->BUSULFAN

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Myocet® Non Formulary other cytotoxic antibiotics->DOXORUBICIN HYDROCHLORIDE->Lipid formulation

8.2 Drugs affecting the immune response->8.2.4 Natalizumab Non Formulary Not relevant to QVH. Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 NATALIZUMAB Non Formulary TA127 http://www.nice.org.uk/TA127 Not relevant to QVH. Other immunomodulating drugs->Natalizumab 8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Navelbine® Non Formulary etoposide->VINORELBINE

NELARABINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Nexavar® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->SORAFENIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic NILOTINIB Non Formulary TA241 http://www.nice.org.uk/TA241 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic NILOTINIB Non Formulary TA251 http://www.nice.org.uk/TA251 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Nipent® Non Formulary drugs->Pentostatin->PENTOSTATIN

8.3 Sex hormones and hormone antagonists in NORETHISTERONE Non Formulary malignant disease->8.3.2 Progestogens

8.2 Drugs affecting the immune response->8.2.2 Nulojix® Non Formulary Corticosteroids and other immunosuppressants->BELATACEPT

8.2 Drugs affecting the immune response->8.2.3 OBINUTUZUMAB Non Formulary TA343 http://www.nice.org.uk/TA343 Anti-lymphocyte monoclonal antibodies

8.3 Sex hormones and hormone antagonists in OCTREOTIDE Non Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.3 Somatostatin analogues

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Octreotide Non Formulary antagonists->8.3.4.3 Somatostatin analogues->OCTREOTIDE

8.2 Drugs affecting the immune response->8.2.3 OFATUMUMAB Non Formulary TA344 http://www.nice.org.uk/TA344 Not relevant to QVH. Anti-lymphocyte monoclonal antibodies

8.2 Drugs affecting the immune response->8.2.3 OFATUMUMAB Non Formulary TA202 http://www.nice.org.uk/TA202 Not relevant to QVH. Anti-lymphocyte monoclonal antibodies

8.2 Drugs affecting the immune response->8.2.4 OncoTICE® Non Formulary Other immunomodulating drugs->BCG bladder instillation->BACILLUS CALMETTE-GU�RIN

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Oncovin® Non Formulary etoposide->VINCRISTINE SULFATE 8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Onkotrone® Non Formulary other cytotoxic antibiotics->MITOXANTRONE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic OXALIPLATIN Non Formulary TA100 http://www.nice.org.uk/TA100 Not relevant to QVH. drugs->Platinum compounds

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic OXALIPLATIN Non Formulary TA212 http://www.nice.org.uk/TA212 Not relevant to QVH. drugs->Platinum compounds

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Oxaliplatin Non Formulary Not relevant to QVH. drugs->Platinum compounds->OXALIPLATIN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PACLITAXEL Non Formulary TA91 http://www.nice.org.uk/TA91 Not relevant to QVH. drugs->Taxanes

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PACLITAXEL Non Formulary TA55 http://www.nice.org.uk/TA55 Not relevant to QVH. drugs->Taxanes

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PACLITAXEL Non Formulary TA108 http://www.nice.org.uk/TA108 Not relevant to QVH. drugs->Taxanes

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Paclitaxel Non Formulary Not relevant to QVH. drugs->Taxanes->PACLITAXEL

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced PALIFERMIN Non Formulary side-effects->Chemotherapy-induced mucositis and myelosuppression

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Panitumumab Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PANITUMUMAB Non Formulary TA242 http://www.nice.org.uk/TA242 Not relevant to QVH drugs->Panitumumab

8.3 Sex hormones and hormone antagonists in PASIREOTIDE Non Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.3 Somatostatin analogues

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PAZOPANIB Non Formulary TA215 http://www.nice.org.uk/TA215 Not relevant to QVH. drugs->Protein kinase inhibitors

8.2 Drugs affecting the immune response->8.2.4 Pegasys® Non Formulary Other immunomodulating drugs->Interferon Not relevant to QVH. alfa->PEGINTERFERON ALFA

8.2 Drugs affecting the immune response->8.2.4 PEGINTERFERON ALFA Non Formulary TA331 http://www.nice.org.uk/TA331 Not relevant to QVH. Other immunomodulating drugs->Interferon alfa 8.2 Drugs affecting the immune response->8.2.4 PEGINTERFERON ALFA Non Formulary TA200 http://www.nice.org.uk/TA200 Not relevant to QVH. Other immunomodulating drugs->Interferon alfa

8.2 Drugs affecting the immune response->8.2.4 PEGINTERFERON ALFA Non Formulary TA200 http://www.nice.org.uk/TA200 Not relevant to QVH. Other immunomodulating drugs->Interferon alfa

8.2 Drugs affecting the immune response->8.2.4 PEGINTERFERON BETA-1a Non Formulary Other immunomodulating drugs->Interferon beta

PEMETREXED Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA124 http://www.nice.org.uk/TA124 Not relevant to QVH.

PEMETREXED Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA190 http://www.nice.org.uk/TA190 Not relevant to QVH.

PEMETREXED Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA181 http://www.nice.org.uk/TA181 Not relevant to QVH.

PEMETREXED Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA309 http://www.nice.org.uk/TA309 Not relevant to QVH.

PEMETREXED Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA135 http://www.nice.org.uk/TA135 Not relevant to QVH.

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Pentostatin Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PENTOSTATIN Non Formulary drugs->Pentostatin

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Perjeta Non Formulary drugs->Pertuzumab->PERTUZUMAB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Pertuzumab Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PERTUZUMAB Non Formulary drugs->Pertuzumab

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Pharmorubicin® Non Formulary other cytotoxic antibiotics->EPIRUBICIN for HYDROCHLORIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Photofrin® Non Formulary drugs->Porfimer sodium and temoporfin->PORFIMER SODIUM

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and PIXANTRONE Non Formulary TA306 http://www.nice.org.uk/TA306 Not relevant to QVH other cytotoxic antibiotics

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Pixuvri® Non Formulary Not relevant to QVH other cytotoxic antibiotics->PIXANTRONE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Platinum compounds Non Formulary Not relevant to QVH. drugs 8.2 Drugs affecting the immune response->8.2.4 Plegridy® Non Formulary Other immunomodulating drugs->Interferon beta->PEGINTERFERON BETA-1a

8.2 Drugs affecting the immune response->8.2.4 POMALIDOMIDE Non Formulary Other immunomodulating drugs->Lenalidomide, TA338 http://www.nice.org.uk/TA338 pomalidomide, and thalidomide

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PONATINIB Non Formulary drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PORFIMER SODIUM Non Formulary drugs->Porfimer sodium and temoporfin

Porfimer sodium and 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Non Formulary temoporfin drugs

8.3 Sex hormones and hormone antagonists in Preparations Non Formulary malignant disease->8.3.1 Oestrogens->ETHINYLESTRADIOL

8.3 Sex hormones and hormone antagonists in Preparations Non Formulary malignant disease->8.3.2 Progestogens->NORETHISTERONE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Procarbazine Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic PROCARBAZINE Non Formulary drugs->Procarbazine

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Procarbazine Non Formulary drugs->Procarbazine->PROCARBAZINE

8.2 Drugs affecting the immune response->8.2.2 Prograf® Non Formulary Corticosteroids and other immunosuppressants->TACROLIMUS

8.2 Drugs affecting the immune response->8.2.4 Proleukin® Non Formulary Other immunomodulating drugs->Aldesleukin->ALDESLEUKIN

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Prostap® 3 DCS Non Formulary gonadotrophin-releasing hormone antagonists->Gonadorelin analogues->LEUPRORELIN ACETATE 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Protein kinase inhibitors Non Formulary Not relevant to QVH. drugs

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.2 Provera® Non Formulary Progestogens->MEDROXYPROGESTERONE ACETATE

8.1 Cytotoxic drugs->8.1.3 Puri-Nethol® Non Formulary Antimetabolites->MERCAPTOPURINE

RALTITREXED Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites Not relevant to QVH.

8.2 Drugs affecting the immune response->8.2.2 Rapamune® Non Formulary Corticosteroids and other Not relevant to QVH. immunosuppressants->SIROLIMUS

8.2 Drugs affecting the immune response->8.2.4 Rebif® Non Formulary Other immunomodulating drugs->Interferon beta->INTERFERON BETA->Interferon beta-1a

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic REGORAFENIB Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Removab® Non Formulary drugs->Catumaxomab->CATUMAXOMAB

8.2 Drugs affecting the immune response->8.2.4 Revlimid® Non Formulary Other immunomodulating drugs->Lenalidomide, Not relevant to QVH. pomalidomide, and thalidomide->LENALIDOMIDE

8.2 Drugs affecting the immune response->8.2.3 RITUXIMAB Non Formulary TA65 http://www.nice.org.uk/TA65 Not relevant to QVH for these indications. Patients would be referred for this treatment elsewhere Anti-lymphocyte monoclonal antibodies

8.2 Drugs affecting the immune response->8.2.3 RITUXIMAB Non Formulary TA308 http://www.nice.org.uk/TA308 Not relevant to QVH for these indications. Patients would be referred for this treatment elsewhere Anti-lymphocyte monoclonal antibodies

8.2 Drugs affecting the immune response->8.2.3 RITUXIMAB Non Formulary TA226 http://www.nice.org.uk/TA226 Not relevant to QVH for these indications. Patients would be referred for this treatment elsewhere Anti-lymphocyte monoclonal antibodies

8.2 Drugs affecting the immune response->8.2.3 RITUXIMAB Non Formulary TA193 http://www.nice.org.uk/TA193 Not relevant to QVH for these indications. Patients would be referred for this treatment elsewhere Anti-lymphocyte monoclonal antibodies

8.2 Drugs affecting the immune response->8.2.3 RITUXIMAB Non Formulary TA174 http://www.nice.org.uk/TA174 Not relevant to QVH for these indications. Patients would be referred for this treatment elsewhere Anti-lymphocyte monoclonal antibodies

8.2 Drugs affecting the immune response->8.2.3 RITUXIMAB Non Formulary TA137 http://www.nice.org.uk/TA137 Not relevant to QVH for these indications. Patients would be referred for this treatment elsewhere Anti-lymphocyte monoclonal antibodies 8.2 Drugs affecting the immune response->8.2.3 RITUXIMAB Non Formulary TA243 http://www.nice.org.uk/TA243 Not relevant to QVH for these indications. Patients would be referred for this treatment elsewhere Anti-lymphocyte monoclonal antibodies

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic RUXOLITINIB Non Formulary TA289 http://www.nice.org.uk/TA289 Not relevant to QVH drugs->Protein kinase inhibitors

8.2 Drugs affecting the immune response->8.2.2 Initiation on advice of consultant for prevention of acute rejection episodes for ophthalmology. Available as Sandimmun® Non Formulary Corticosteroids and other 2% eye ointment - UNLICENSED. immunosuppressants->CICLOSPORIN Consultant dermatologist and rheumatologist.

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Sandostatin Lar® Non Formulary antagonists->8.3.4.3 Somatostatin analogues->OCTREOTIDE->Depot preparation

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Sandostatin® Non Formulary antagonists->8.3.4.3 Somatostatin analogues->OCTREOTIDE

8.1 Cytotoxic drugs->Treatment for Savene® Non Formulary cytotoxic-induced side-effects->Anthracycline side-effects->DEXRAZOXANE

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Signifor® Non Formulary antagonists->8.3.4.3 Somatostatin analogues->PASIREOTIDE

8.2 Drugs affecting the immune response->8.2.4 SILTUXIMAB Non Formulary Other immunomodulating drugs->Siltuximab

8.2 Drugs affecting the immune response->8.2.2 Simulect® Non Formulary Corticosteroids and other Not relevant to QVH. immunosuppressants->BASILIXIMAB

8.2 Drugs affecting the immune response->8.2.2 SIROLIMUS Non Formulary Not relevant to QVH. Corticosteroids and other immunosuppressants

8.1 Cytotoxic drugs->Treatment for cytotoxic-induced Sodiofolin® Non Formulary side-effects->Chemotherapy-induced mucositis Not relevant to QVH. and myelosuppression->FOLINIC ACID->Disodium folinate 8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Somatuline Autogel® Non Formulary antagonists->8.3.4.3 Somatostatin analogues->LANREOTIDE

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Somatuline® LA Non Formulary antagonists->8.3.4.3 Somatostatin analogues->LANREOTIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic SORAFENIB Non Formulary TA189 http://www.nice.org.uk/TA189 Not relevant to QVH drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic SORAFENIB Non Formulary TA178 http://www.nice.org.uk/TA178 Not relevant to QVH drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Sprycel® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->DASATINIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Stivarga® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->REGORAFENIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic SUNITINIB Non Formulary TA178 http://www.nice.org.uk/TA178 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic SUNITINIB Non Formulary TA169 http://www.nice.org.uk/TA169 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic SUNITINIB Non Formulary TA179 http://www.nice.org.uk/TA179 Not relevant to QVH. drugs->Protein kinase inhibitors

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Suprefact® Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Gonadorelin analogues->BUSERELIN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Sutent® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->SUNITINIB

8.2 Drugs affecting the immune response->8.2.4 Sylvant® Non Formulary Other immunomodulating drugs->Siltuximab->SILTUXIMAB

8.2 Drugs affecting the immune response->8.2.2 Tacni® Non Formulary Corticosteroids and other immunosuppressants->TACROLIMUS 8.2 Drugs affecting the immune response->8.2.2 TACROLIMUS Non Formulary Corticosteroids and other immunosuppressants

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Tafinlar® Non Formulary drugs->Protein kinase inhibitors->DABRAFENIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Tarceva® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->ERLOTINIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Targretin® Non Formulary drugs->Bexarotene->BEXAROTENE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Tasigna® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->NILOTINIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Taxanes Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Taxotere® Non Formulary Not relevant to QVH. drugs->Taxanes->DOCETAXEL

8.2 Drugs affecting the immune response->8.2.4 Tecfidera® Non Formulary Other immunomodulating drugs->Dimethyl Not relevant to QVH fumarate->DIMETHYL FUMARATE

TEGAFUR WITH GIMERACIL AND Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites OTERACIL

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Temodal® Non Formulary drugs->Dacarbazine and Not relevant to QVH. temozolomide->TEMOZOLOMIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TEMOPORFIN Non Formulary drugs->Porfimer sodium and temoporfin

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TEMOZOLOMIDE Non Formulary TA23 http://www.nice.org.uk/TA23 Not relevant to QVH. drugs->Dacarbazine and temozolomide

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TEMOZOLOMIDE Non Formulary TA121 http://www.nice.org.uk/TA121 Not relevant to QVH. drugs->Dacarbazine and temozolomide

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Temozolomide Non Formulary drugs->Dacarbazine and Not relevant to QVH. temozolomide->TEMOZOLOMIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TEMSIROLIMUS Non Formulary TA178 http://www.nice.org.uk/TA178 Not relevant to QVH. drugs->Protein kinase inhibitors 8.1 Cytotoxic drugs->8.1.1 Alkylating Tepadina® Non Formulary drugs->THIOTEPA

8.2 Drugs affecting the immune response->8.2.4 Teriflunomide Non Formulary Not relevant to QVH Other immunomodulating drugs

8.2 Drugs affecting the immune response->8.2.4 TERIFLUNOMIDE Non Formulary TA303 http://www.nice.org.uk/TA303 Not relevant to QVH. Other immunomodulating drugs->Teriflunomide

8.1 Cytotoxic drugs->8.1.3 Teysuno® Non Formulary Antimetabolites->TEGAFUR WITH GIMERACIL AND OTERACIL

8.2 Drugs affecting the immune response->8.2.4 THALIDOMIDE Non Formulary Other immunomodulating drugs->Lenalidomide, TA228 http://www.nice.org.uk/TA228 Not relevant to QVH. pomalidomide, and thalidomide

8.2 Drugs affecting the immune response->8.2.4 Thalidomide Celgene® Non Formulary Other immunomodulating drugs->Lenalidomide, Not relevant to QVH. pomalidomide, and thalidomide->THALIDOMIDE

THIOTEPA Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs

8.2 Drugs affecting the immune response->8.2.2 Corticosteroids and other Thymoglobuline® Non Formulary immunosuppressants->ANTITHYMOCYTE IMMUNOGLOBULIN (RABBIT)

TIOGUANINE Non Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites

8.1 Cytotoxic drugs->8.1.3 Tomudex® Non Formulary Not relevant to QVH. Antimetabolites->RALTITREXED

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Topoisomerase I inhibitors Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TOPOTECAN Non Formulary TA184 http://www.nice.org.uk/TA184 Not relevant to QVH. drugs->Topoisomerase I inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TOPOTECAN Non Formulary TA183 http://www.nice.org.uk/TA183 Not relevant to QVH. drugs->Topoisomerase I inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TOPOTECAN Non Formulary TA91 http://www.nice.org.uk/TA91 Not relevant to QVH. drugs->Topoisomerase I inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Topotecan Non Formulary Not relevant to QVH. drugs->Topoisomerase I inhibitors->TOPOTECAN 8.3 Sex hormones and hormone antagonists in TOREMIFENE Non Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.1 Breast cancer

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Torisel® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->TEMSIROLIMUS

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Trabectedin Non Formulary Not relevant to QVH. drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TRABECTEDIN Non Formulary TA222 http://www.nice.org.uk/TA222 Not relevant to QVH. drugs->Trabectedin

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TRABECTEDIN Non Formulary TA185 http://www.nice.org.uk/TA185 Not relevant to QVH. drugs->Trabectedin

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Trastuzumab Non Formulary Not relevant to QVH. drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TRASTUZUMAB Non Formulary TA208 http://www.nice.org.uk/TA208 Not relevant to QVH. drugs->Trastuzumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TRASTUZUMAB Non Formulary TA257 http://www.nice.org.uk/TA257 Not relevant to QVH. drugs->Trastuzumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TRASTUZUMAB Non Formulary TA107 http://www.nice.org.uk/TA107 Not relevant to QVH. drugs->Trastuzumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TRASTUZUMAB Non Formulary TA34 http://www.nice.org.uk/TA34 Not relevant to QVH. drugs->Trastuzumab

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Trastuzumab emtansine Non Formulary drugs

TRASTUZUMAB 8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Non Formulary EMTANSINE drugs->Trastuzumab emtansine

TREOSULFAN Non Formulary 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs

8.1 Cytotoxic drugs->8.1.1 Alkylating Treosulfan Non Formulary drugs->TREOSULFAN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Tretinoin Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic TRETINOIN Non Formulary drugs->Tretinoin 8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone TRIPTORELIN Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Gonadorelin analogues

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Trisenox® Non Formulary drugs->Arsenic trioxide->ARSENIC TRIOXIDE

8.2 Drugs affecting the immune response->8.2.4 Tysabri® Non Formulary Other immunomodulating Not relevant to QVH. drugs->Natalizumab->NATALIZUMAB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Tyverb® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->LAPATINIB

8.1 Cytotoxic drugs->Treatment for Urothelial toxicity Non Formulary cytotoxic-induced side-effects

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic VANDETANIB Non Formulary drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Vectibix® Non Formulary Not relevant to QVH drugs->Panitumumab->PANITUMUMAB

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Velbe® Non Formulary etoposide->VINBLASTINE SULFATE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Velcade® Non Formulary Not relevant to QVH. drugs->Bortezomib->BORTEZOMIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic VEMURAFENIB Non Formulary TA269 http://www.nice.org.uk/TA269 Not relevant to QVH. drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Vepesid® Non Formulary etoposide->ETOPOSIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Vesanoid® Non Formulary drugs->Tretinoin->TRETINOIN

8.1 Cytotoxic drugs->8.1.3 Vidaza® Non Formulary Not relevant to QVH Antimetabolites->AZACITIDINE

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Vinblastine Non Formulary etoposide->VINBLASTINE SULFATE

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and VINBLASTINE SULFATE Non Formulary etoposide 8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Vincristine Non Formulary etoposide->VINCRISTINE SULFATE

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and VINCRISTINE SULFATE Non Formulary etoposide

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and VINDESINE SULFATE Non Formulary etoposide

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and VINFLUNINE Non Formulary TA272 http://www.nice.org.uk/TA272 Not relevant to QVH etoposide

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and VINORELBINE Non Formulary etoposide

8.1 Cytotoxic drugs->8.1.4 Vinca alkaloids and Vinorelbine Non Formulary etoposide->VINORELBINE

8.2 Drugs affecting the immune response->8.2.4 ViraferonPeg® Non Formulary Other immunomodulating drugs->Interferon Not relevant to QVH. alfa->PEGINTERFERON ALFA

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Vismodegib Non Formulary drugs

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic VISMODEGIB Non Formulary drugs->Vismodegib

8.2 Drugs affecting the immune response->8.2.2 Vivadex® Non Formulary Corticosteroids and other immunosuppressants->TACROLIMUS

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Votrient® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->PAZOPANIB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Votubia® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->EVEROLIMUS

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Xalkori® Non Formulary Not relevant to QVH drugs->Protein kinase inhibitors->CRIZOTINIB

8.1 Cytotoxic drugs->8.1.3 Xaluprine® Non Formulary Antimetabolites->MERCAPTOPURINE

8.1 Cytotoxic drugs->8.1.3 Xeloda® Non Formulary Not relevant to QVH Antimetabolites->CAPECITABINE 8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Xtandi® Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and Not relevant to QVH gonadotrophin-releasing hormone antagonists->Anti-androgens->ENZALUTAMIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Yervoy® Non Formulary Not relevant to QVH. drugs->Ipilimumab->IPILIMUMAB

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Yondelis® Non Formulary Not relevant to QVH. drugs->Trabectedin->TRABECTEDIN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Zaltrap® Non Formulary Not relevant to QVH drugs->Aflibercept->AFLIBERCEPT

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Zavedos® Non Formulary other cytotoxic antibiotics->IDARUBICIN HYDROCHLORIDE

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Zelboraf® Non Formulary Not relevant to QVH. drugs->Protein kinase inhibitors->VEMURAFENIB

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Zoladex® Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Gonadorelin analogues->GOSERELIN

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Zoladex® LA Non Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Gonadorelin analogues->GOSERELIN

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Zydelig® Non Formulary drugs->Protein kinase inhibitors->IDELALISIB

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Zytiga® Non Formulary Not relevant to QVH. gonadotrophin-releasing hormone antagonists->Anti-androgens->ABIRATERONE ACETATE

8.3 Sex hormones and hormone antagonists in On Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.1 Breast cancer 8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Anastrozole On Formulary antagonists->8.3.4.1 Breast cancer->ANASTROZOLE

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Arimidex® On Formulary antagonists->8.3.4.1 Breast cancer->ANASTROZOLE

8.2 Drugs affecting the immune response->8.2.1 AZATHIOPRINE On Formulary Dermatology and rheumatology initiation only Antiproliferative immunosuppressants

8.2 Drugs affecting the immune response->8.2.1 Azathioprine On Formulary Antiproliferative Dermatology and rheumatology initiation only. TPMT pre-dosing needed. immunosuppressants->AZATHIOPRINE

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone On Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Anti-androgens

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Bicalutamide On Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Anti-androgens->BICALUTAMIDE

Initiation on advice of consultant for prevention of acute rejection episodes for ophthalmology. Available as 8.2 Drugs affecting the immune response->8.2.2 0.2% eye ointment and 2% preservative free eyedrops- UNLICENSED. Capimune® On Formulary Corticosteroids and other immunosuppressants->CICLOSPORIN Consultant dermatologist and rheumatologist initation only CICLOSPORIN in BURNS

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone Casodex® On Formulary antagonists->8.3.4.2 Gonadorelin analogues and gonadotrophin-releasing hormone antagonists->Anti-androgens->BICALUTAMIDE

Initiation on advice of consultant for prevention of acute rejection episodes for ophthalmology. Available as 0.2% eye ointment and 2% preservative free eyedrops- UNLICENSED. 8.2 Drugs affecting the immune response->8.2.2 CICLOSPORIN On Formulary Corticosteroids and other immunosuppressants Consultant dermatologist and rheumatologist initation only CICLOSPORIN in BURNS 8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Cyprostat® On Formulary 100mg TDS DOSE gonadotrophin-releasing hormone antagonists->Anti-androgens->CYPROTERONE ACETATE

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone On Formulary antagonists->8.3.4.2 Gonadorelin analogues and 100mg TDS DOSE gonadotrophin-releasing hormone antagonists->Anti-androgens

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Cyproterone Acetate On Formulary 100mg TDS DOSE gonadotrophin-releasing hormone antagonists->Anti-androgens->CYPROTERONE ACETATE

8.2 Drugs affecting the immune response->8.2.1 Imuran® On Formulary Antiproliferative Dermatology and rheumatology initiation only. TPMT pre-dosing needed. immunosuppressants->AZATHIOPRINE

Dermatology and rheumatology initiation only. Weekly dose. Follow policy. METHOTREXATE On Formulary 8.1 Cytotoxic drugs->8.1.3 Antimetabolites Methotrexate Policy

8.1 Cytotoxic drugs->8.1.3 Methotrexate On Formulary Dermatology and rheumatology initiation only. Weekly dose. Follow policy Antimetabolites->METHOTREXATE

.Initiation on advice of consultant for prevention of acute rejection episodes for ophthalmology. Available as 8.2 Drugs affecting the immune response->8.2.2 0.2% eye ointment and 2% preservative free eyedrops- UNLICENSED. Neoral® On Formulary Corticosteroids and other immunosuppressants->CICLOSPORIN Consultant dermatologist and rheumatologist initation only CICLOSPORIN in BURNS

8.1 Cytotoxic drugs->8.1.3 Oral preparations On Formulary Dermatology and rheumatology initiation only. Weekly dose. Follow policy Antimetabolites->METHOTREXATE

8.3 Sex hormones and hormone antagonists in On Formulary malignant disease->8.3.4 Hormone Advise to stop 4 weeks before major breast surgery and restart 2 weeks after. antagonists->8.3.4.1 Breast cancer

8.3 Sex hormones and hormone antagonists in Tamoxifen On Formulary malignant disease->8.3.4 Hormone antagonists->8.3.4.1 Breast cancer->TAMOXIFEN Consultant dermatologist only as 2nd or 3rd line for autoimmune blistering. Funding agreement needed from 8.2 Drugs affecting the immune response->8.2.1 PCT. CellCept® Restricted Antiproliferative Ophthalmology consultant only for prevention of acute rejection in high risk patients with corneal grafts or immunosuppressants->MYCOPHENOLATE MOFETIL limbal stem cell grafts. Both UNLICENSED indications.

Ophthalmology only for ocular cicatricial pemphigoid see trust guidelines. Hand-held patient booklet and CYCLOPHOSPHAMIDE Restricted 8.1 Cytotoxic drugs->8.1.1 Alkylating drugs treatment plan from clinic. Cyclophosphamide Policy

8.1 Cytotoxic drugs->8.1.1 Alkylating Ophthalmology only for ocular cicatricial pemphigoid see trust guidelines. Hand-held patient booklet and Cyclophosphamide Restricted drugs->CYCLOPHOSPHAMIDE treatment plan from clinic.

Ophthalmology only topical or intra-ocular injection. Only available as 10mg in 0.4ml. UNLICENSED. FLUOROURACIL Restricted 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA307 http://www.nice.org.uk/TA307 Not relevant at QVH for NICE indication.

Ophthalmology only topical or intra-ocular injection. Only available as 10mg in 0.4ml. UNLICENSED. FLUOROURACIL Restricted 8.1 Cytotoxic drugs->8.1.3 Antimetabolites TA212 http://www.nice.org.uk/TA212 Not relevant at QVH for NICE indication.

8.1 Cytotoxic drugs->8.1.3 Ophthalmology only topical or intra-ocular injection. Only available as 10mg in 0.4ml. UNLICENSED. Fluorouracil Restricted Antimetabolites->FLUOROURACIL Not relevant at QVH for NICE indication.

Consultant ophthalmologist only. Injection (Roferon) -UNLICENSED use. 1million units/ml eyedrops, not 8.2 Drugs affecting the immune response->8.2.4 Interferon alfa Restricted routinely stocked must be ordered for individual patients and is only made every 4 weeks - UNLICENSED. PCT Other immunomodulating drugs funding approval needed before initiation of eyedrops.Not relevant to QVH for hepatitis

Consultant ophthalmologist only. Injection (Roferon) -UNLICENSED use. 1million units/ml eyedrops, not 8.2 Drugs affecting the immune response->8.2.4 INTERFERON ALFA Restricted TA200 http://www.nice.org.uk/TA200 routinely stocked must be ordered for individual patients and is only made every 4 weeks - UNLICENSED. PCT Other immunomodulating drugs->Interferon alfa funding approval needed before initiation of eyedrops.Not relevant to QVH for hepatitis

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone ACETATE Restricted antagonists->8.3.4.2 Gonadorelin analogues and Consultant Urologist only gonadotrophin-releasing hormone antagonists->Gonadorelin analogues

Ophthalmology only topical or intra-ocular injection. Must be ordered at least 3 full working days before 8.1 Cytotoxic drugs->8.1.2 Anthracyclines and MITOMYCIN Restricted required. Only available as 0.02% or 0.04% in 1ml injection or preservative-free 0.02% or 0.04% eyedrops. other cytotoxic antibiotics UNLICENSED.

Ophthalmology only topical or intra-ocular injection. Must be ordered at least 3 full working days before 8.1 Cytotoxic drugs->8.1.2 Anthracyclines and Mitomycin C Kyowa® Restricted required. Only available as 0.02% or 0.04% in 1ml injection or preservative-free 0.02% or 0.04% eyedrops. other cytotoxic antibiotics->MITOMYCIN UNLICENSED.

Consultant dermatologist only as 2nd or 3rd line for autoimmune blistering. Funding agreement needed from MYCOPHENOLATE 8.2 Drugs affecting the immune response->8.2.1 PCT. Restricted MOFETIL Antiproliferative immunosuppressants Ophthalmology consultant only for prevention of acute rejection in high risk patients with corneal grafts or limbal stem cell grafts. Both UNLICENSED indications. Consultant dermatologist only as 2nd or 3rd line for autoimmune blistering. Funding agreement needed from 8.2 Drugs affecting the immune response->8.2.1 PCT. Mycophenolate Mofetil Restricted Antiproliferative Ophthalmology consultant only for prevention of acute rejection in high risk patients with corneal grafts or immunosuppressants->MYCOPHENOLATE MOFETIL limbal stem cell grafts. Both UNLICENSED indications.

8.3 Sex hormones and hormone antagonists in malignant disease->8.3.4 Hormone antagonists->8.3.4.2 Gonadorelin analogues and Prostap® SR DCS Restricted Consultant Urologist only gonadotrophin-releasing hormone antagonists->Gonadorelin analogues->LEUPRORELIN ACETATE

8.2 Drugs affecting the immune response->8.2.4 Consultant ophthalmologist only. Injection (Roferon) -UNLICENSED use. 1million units/ml eyedrops, not Roferon-A® Restricted Other immunomodulating drugs->Interferon routinely stocked must be ordered for individual patients and is only made every 4 weeks - UNLICENSED. PCT alfa->INTERFERON ALFA funding approval needed before initiation of eyedrops.Not relevant to QVH for hepatitis

8.1 Cytotoxic drugs->8.1.2 Anthracyclines and DaunoXome® None other cytotoxic antibiotics->DAUNORUBICIN->Lipid formulation

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic IBRUTINIB None drugs->Protein kinase inhibitors

8.1 Cytotoxic drugs->8.1.5 Other antineoplastic Imbruvica® None drugs->Protein kinase inhibitors->IBRUTINIB