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V39N11(Suppl).Pdf AAMS Annals of the Academy of Medicine, Singapore VOLUME 39 (SUPPLEMENT) NUMBER 11 1st SHBC 2010 NOVEMBER 2010 Proceedings of the 1st Singapore Health & Biomedical Congress 12 - 13 November 2010 | Suntec Singapore International Convention & Exhibition Centre IMPROVING HEALTH IN OUR COMMUNITY A HOLISTIC AND INTEGRATED APPROACH Organised by Annals Editorial Board Specialist Advisory Panel Editor Balram Chowbay Eng King Tan Fun Gee Chen Tou Choong Chang Deputy Editors Kok Yong Fong Erle CH Lim Kei Siong Khoo Hui Kim Yap London Lucien Ooi Bien Soo Tan Associate Editors Hugo van Bever Kah Yin Loke Beng Yeong Ng Editorial Executive Pierce KH Chow Hui Chee Chan Deborah Tan Emeritus Editor Vernon MS Oh International Advisory Panel Board Members Juliana C N Chan, Hong Kong, SAR China Yock Young Dan Richard N Fine, USA Kenneth Kwek Yik Hong Ho, Australia KK Madhavan Edward Holmes, Singapore Stefan SL Ma Richard H Hunt, Canada Yih Yian Sitoh Ranga Krishnan, Singapore Seang Mei Saw Edison Liu, Singapore A Vathsala Harvey Marcovitch, UK Richard Sim Albert Singer, UK ACADEMY OF MEDICINE SINGAPORE ACADEMY OF MEDICINE SINGAPORE Immediate Past Editor Vernon MS Oh Ex-Officio Kok Chai Tan Boon Keng Ng We welcome submissions of cover images from Fellows and Friends of the Academy of Medicine for consideration for publication. Do submit interesting or unusual photographs or digitised images of original artwork, accompanied by a short write-up of about 30 words. Format: 8 by 12 cm, resolution of at least 300 dpi, in JPEG or TIFF. Please email your submission to [email protected] Printed by Straits Printers (Pte) Ltd ISSN 0304-4602 MICA (P) 184/10/2009 Academy of Medicine, Singapore Vol. 39 (Suppl) No. 11 November 2010 1st Singapore Health & Biomedical Congress (SHBC) 2010 CONTENTS List of Committees Finalists Singapore Clinician-Investigator Award…………………………………………………………..S1 Singapore Allied Health Award…………………………………………………………………...S6 Singapore Nursing Award…………………………………………………………………………S9 Singapore Young Investigator Award – Basic Science Research/Translational Research……....S12 Singapore Young Investigator Award – Clinical Research……………………………………....S15 Singapore Young Investigator Award – Quality, Health Services Research…………………….S18 SHBC Best Poster Award – Allied Health…………………………………………………….....S21 SHBC Best Poster Award – Basic Science Research/Translational Research…………………...S23 SHBC Best Poster Award – Clinical Research…………………………………………………...S26 SHBC Best Poster Award – Nursing……………………………………………………………..S29 SHBC Best Poster Award – Quality, Health Services Research…………………………………S31 Oral Presentation Abstracts Allied Health……………………………………………………………………………………..S34 Basic Science Research/Translational Research…………………………………………………S81 Clinical Research………………………………………………………………………………..S111 Nursing………………………………………………………………………………………….S207 Quality, Health Services Research ……………………………………………………………..S226 Poster Presentation Abstracts Allied Health……………………………………………………………………………………S254 Basic Science Research/Translational Research………………………………………………..S302 Clinical Research………………………………………………………………………………..S324 Nursing………………………………………………………………………………………….S371 Quality, Health Services Research……………………………………………………………...S377 Index of First Author.................................................................................................................S396 1st Singapore Health & Biomedical Congress (SHBC) 2010 Organising Committee Chairperson A/Prof Quek Swee Chye National University Hospital Members Dr Lee Chee Keong Jimmy Institute of Mental Health Dr Steven Thng National Skin Centre A/Prof Chng Wee Joo National University Hospital A/Prof Poh Kian Keong National University Hospital Dr Ong Kiat Hoe Tan Tock Seng Hospital Scientific Committee Chairperson A/Prof Chng Wee Joo National University Hospital Members Dr Lee Chee Keong Jimmy Institute of Mental Health Dr Tang Wern Ee National Healthcare Group Polyclinics Dr Steven Thng National Skin Centre A/Prof Lee Yung Seng National University Hospital Dr Christopher Khor National University Hospital A/Prof Poh Kian Keong National University Hospital Dr Ong Kiat Hoe Tan Tock Seng Hospital Scientific Review Committee (in alphabetical order, according to Institutions) Members Dr Sim Kang Institute of Mental Health Dr Verma Swapna Institute of Mental Health A/Prof Daniel Fung Institute of Mental Health Dr Lee Chee Keong Jimmy Institute of Mental Health Ms Poh Chee Lien Institute of Mental Health A/Prof Chong Siow Ann Institute of Mental Health Mr Cai Cong Cong Jurong General Hospital Ms Chua Gek Choo Khoo Teck Puat Hospital Ms Gladys Wong Khoo Teck Puat Hospital Prof Koh Kwong Fah Khoo Teck Puat Hospital Dr Tavintharan Khoo Teck Puat Hospital Dr Yip Chee Chew Khoo Teck Puat Hospital Dr Kenneth Mak Khoo Teck Puat Hospital A/Prof Lim Su Chi Khoo Teck Puat Hospital Dr Edwin Seet Khoo Teck Puat Hospital Dr Teh Hui Seong Khoo Teck Puat Hospital Ms Sharon Pek Khoo Teck Puat Hospital Dr Philip Yap Khoo Teck Puat Hospital Dr Tan Kok Yang Khoo Teck Puat Hospital Ms Chan Kar Lock Khoo Teck Puat Hospital Ms Toy Wan Ching Khoo Teck Puat Hospital Ms Chan Sue Mei Khoo Teck Puat Hospital Dr Heng Bee Hoon National Healthcare Group HQ Dr Melvin Leow National Healthcare Group HQ Ms Chan Soo Chung National Healthcare Group Pharmacy Dr Lew Yii Jen National Healthcare Group Polyclinics Dr Tang Wern Ee National Healthcare Group Polyclinics A/Prof Cheah Wei Keat National University Health System A/Prof Chng Wee Joo National University Health System A/Prof Paul Tambyah National University Health System A/Prof Raymond Lin National University Health System Dr Ross Soo National University Health System Ms Siti Zubaidah National University Health System A/Prof Tan Huay Cheem National University Health System Mr Wu Tuck Seng National University Health System A/Prof Adeline Seow National University Health System Prof Yong Eu Leong National University Health System A/Prof Lee Yung Seng National University Health System Dr Christopher Khor National University Health System Dr Raymond Wong National University Health System A/Prof Yeo Tiong Cheng National University Health System A/Prof Sunil Sethi National University Health System A/Prof Krishnakumar National University Health System Madhavan Dr James Yip National University Health System Dr Heng Chin Tiong National University Health System A/Prof Poh Kian Keong National University Health System A/Prof Saw Seang Mei National University Health System A/Prof Lai Poh San National University Health System A/Prof Lynette Shek National University Health System Dr Tai E-Shyong National University Health System Dr Tan Poh Lin National University Health System A/Prof Heng Chew Kiat National University Health System Ms Lee Yee Mei National University Health System Dr Mark Chan National University Health System A/Prof Ong Hian Tat National University Health System Prof Quak Seng Hock National University Health System A/Prof Ronald Lee National University Health System A/Prof Samuel Chong National University Health System Dr Alvin Wong National University Health System Dr Yeo Wee Lee National University Health System Dr Raymond Seet National University Health System Dr Gautam Sethi National University of Singapore A/Prof Fred Wong National University of Singapore A/Prof Reshma Taneja National University of Singapore A/Prof Shen Han Ming National University of Singapore Prof Desley Gail Hegney National University of Singapore A/Prof Charmaine Childs National University of Singapore Dr Antonio Bertoletti Singapore Institute for Clinical Sciences Ms Lee Leng Noey Tan Tock Seng Hospital Dr Leong Khai Pang Tan Tock Seng Hospital Dr Patrick Chan Tan Tock Seng Hospital Dr Richard Sim Tan Tock Seng Hospital Dr Stephen Teoh Tan Tock Seng Hospital Mr Wee Seng Kwee Tan Tock Seng Hospital Dr Wu Huei Yaw Tan Tock Seng Hospital Dr David Lye Tan Tock Seng Hospital Dr Liau Kui Hin Tan Tock Seng Hospital Dr Chan Kay Fei Tan Tock Seng Hospital Dr Ong Kiat Hoe Tan Tock Seng Hospital Dr Adrian Liew Tan Tock Seng Hospital Dr Michelle Jong Tan Tock Seng Hospital Dr Colin Tan Tan Tock Seng Hospital Dr Ng Tsun Gun Tan Tock Seng Hospital Dr Tay Jam Chin Tan Tock Seng Hospital 1st Singapore Health & Biomedical Congress 2010 SG-CIA-01 Velo-Cardio-Facial Syndrome Related Gene Influences Neurocognitive and Neuroanatomical Intermediate Phenotypes in Chinese Patients with Schizophrenia K SIM1, WY CHAN2, HQ LOW3, GL YANG4, PS WOON2, YY SITOH5, JJ LIU3, WL NOWINSKI4 1General Psychiatry, Institute of Mental Health, Singapore, 2Research, Institute of Mental Health, Singapore, 3Genome Institute of Singapore, A*STAR, Singapore, 4Biomedical Imaging Laboratory, A*STAR, Singapore, 5Neuroradiology, National Neuroscience Institute, Singapore Background/Hypothesis: There are notable similarities between Velo-Cardio-Facial Syndrome (VCFS) and schizophrenia in terms of neurocognitive deficits and brain structural abnormalities. These similarities have supported the role of the armadillo repeat gene deleted in VCFS (ARVCF gene) as a susceptibility gene in schizophrenia. This study investigates the relationships between haplotypes of ARVCF gene and specific intermediate phenotypes in schizophrenia. Based on extant data, we hypothesise that specific ARVCF gene haplotypes reduce the caudate nucleus volume, fractional anisotropy and neurocognitive functioning in schizophrenia. Methods: Blood samples from 200 Chinese participants (125 schizophrenia patients and 75 healthy controls) were genotyped, a subset of 166 participants underwent structural magnetic resonance imaging
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