PCP4 Rabbit Polyclonal Antibody – TA349214 | Origene

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for TA349214

PCP4 Rabbit Polyclonal Antibody Product data:

Product Type: Primary Antibodies Applications: IHC, WB Recommended Dilution: ELISA: 2000-10000, WB: 500-2000, IHC: 100-300 Reactivity: Human, Mouse, Rat Host: Rabbit Isotype: IgG Clonality: Polyclonal Immunogen: Fusion protein of human PCP4 Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln Concentration: lot specific Purification: Antigen affinity purification Conjugation: Unconjugated Storage: Store at -20°C as received. Stability: Stable for 12 months from date of receipt. Predicted Protein Size: 7 kDa Gene Name: Purkinje cell protein 4 Database Link: NP_006189 Entrez Gene 5121 Human P48539 Background: PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer?s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome. Synonyms: PEP-19

This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 PCP4 Rabbit Polyclonal Antibody – TA349214

Product images:

Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane: Mouse brain tissue, Primary antibody: (PCP4 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using (PCP4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using (PCP4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)