SDHAF2 Antibody Cat. No.: 6507

SDHAF2 Antibody

Specifications

HOST SPECIES: Chicken

SPECIES REACTIVITY: Human, Mouse, Rat

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (93%)

SDHAF2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SDHAF2. IMMUNOGEN:

The immunogen is located within the first 50 amino acids of SDHAF2.

TESTED APPLICATIONS: ELISA, WB

SDHAF2 antibody can be used for detection of SDHAF2 by Western blot at 1 μg/mL.

APPLICATIONS: Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

SDHAF2 antibody is predicted to not cross-react with other SDHAF family SPECIFICITY: members.

POSITIVE CONTROL: 1) Cat. No. 1464 - Rat Liver Tissue Lysate

Properties

PURIFICATION: SDHAF2 Antibody is affinity chromatography purified via peptide column.

September 24, 2021 1 https://www.prosci-inc.com/sdhaf2-antibody-6507.html CLONALITY: Polyclonal

ISOTYPE: IgY

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: SDHAF2 Antibody is supplied in PBS containing 0.02% sodium azide.

CONCENTRATION: 1 mg/mL

SDHAF2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one STORAGE CONDITIONS: year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: SDHAF2

SDHAF2 Antibody: PGL2, SDH5, C11orf79, PGL2, assembly ALTERNATE NAMES: factor 2, mitochondrial, Succinate dehydrogenase subunit 5, SDH assembly factor 2

ACCESSION NO.: NP_060311

PROTEIN GI NO.: 8923450

GENE ID: 54949

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

SDHAF2 Antibody: SDHAF2 (Succinate dehydrogenase complex assembly factor 2) encodes a mitochondrial protein needed for FAD cofactor attach to the SDH enzyme BACKGROUND: which plays a critical role in mitochondria. SDHAF2 is a tumor suppressor, but recent evidence suggests that somatic of the SDHAF2 are unlikely to contribute to parathyroid tumor development in sporadic primary hyperparathyroidism.

1) Hao HX, Khalimonchuk O, Schraders M, et al. SDH5, a required for flavination of REFERENCES: succinate dehydrogenase, is mutated in . Science 2009; 325:1139-42.

2) Burnichon N, Brière JJ, Libé R, et al. SDHA is a causing paraganglioma. Hum. Mol. Genet. 2010; 19:3011-20.

3) Kunst HP, Rutten MH, de Monnink JP, et al. SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma. Clin. Cancer Res. 2011; 17:247-54

4) Starker LF, Delgado-Verdugo A, Udelsman R, et al. Expression and somatic mutations of SDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism. Endocrine 2010; 38:397-401.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 24, 2021 2 https://www.prosci-inc.com/sdhaf2-antibody-6507.html