Supplementary Table 1 NF-B target genes1 were list on the basis of its expression was upregulated by 70% or more in -catulin-overexpressed A549 cells

Gene ID log2 Function category CTNNAL1 3.946 ADAM19* 0.716 Dendritic cell marker Cell-surface receptors ADORA2A 1.095 Adenosine receptor Cell-surface receptors AGER 4.942 Receptor for Advanced Glycation End products Cell-surface receptors AHCTF1* 3.566 Embryonic large molecule derived from yolk sac Transcription factors and their modulators ALOX12 0.966 Arachidonic acid metabolic Stress response ; 12-Lipoxygenase AMACR 1.458 alpha-methylacyl-CoA racemase Growth factors, ligands, and their modulators; ANGPT1 1.965 Tie-2 receptor ligand Angiopoietin APOC3 0.719 Apoprotein of HDL Miscellaneous AR 1.799 Hormone receptor Transcription factors and their modulators ARFRP1 0.914 GTPase Enzymes; ARF-related protein-1 Tripartite gene: aspartyl-beta-hydroxylase, junctin), ASPH 2.758 Miscellaneous junctate B2M 1.039 Chaperone for MHC class I-like molecules Immunoreceptors BCL2L11 1.818 Pro-apoptotic Bcl-2 homolog Regulators of apoptosis BMI1 4.039 Polycomb chromatin modifier Transcription factors and their modulators BMP2 0.867 Bone Morphogenic Protein-2 Growth factors, ligands, and their modulators BNIP3 2.667 Hypoxia-inducible death factor Regulators of apoptosis CAV1* 2.128 Lipid raft protein Miscellaneous CCL15 1.506 Chemokine for cell attraction Cytokines/Chemokines and their modulators CCL5 1.328 T-cell secreted factor Cytokines/Chemokines and their modulators CD83 1.407 T-cell development molecule Immunoreceptors CDK6 4.377 Cell-dependent kinase 6 Enzymes CDKN1A* 1.329 Cyclin-dependent kinase inhibitor Miscellaneous CEBPD 1.072 Transcription factor Transcription factors and their modulators CFLAR 0.700 Pro-survival factor Regulators of apoptosis CHI3L1 1.203 Chitinase Enzymes CYP2E1* 2.195 Cytochrome p450 Stress response genes DCTN4* 2.294 Non-proteasomal multi-ubiquitin chain binding protein Early response genes DPYD* 1.892 Dihydropyrimidine dehydrogenase Enzymes DUSP1* 1.281 MAP kinase phosphatase Enzymes E2F3 2.379 Cell cycle regulator Transcription factors and their modulators EGFR 1.335 Receptor for EGF Cell-surface receptors EGR1* 3.458 Mitogen-induced early response gene; zinc finger Early response genes EDN1 0.993 Vasoconstrictor peptide/mitogen Miscellaneous ENO2* 1.474 Enolase 2 gamma Enzymes FN1 0.869 Extracellular attachment Cell adhesion molecules FOS* 5.318 Proto-oncogene Transcription factors and their modulators GCLC 1.159 GSH biosynthesis Stress response genes GCLM 1.608 GCLC modifier protein Stress response genes GJB1* 0.781 Gap junction protein Miscellaneous GRIN1* 1.057 Subunit of neural receptor for N-methyl-D-aspartate Cell-surface receptors GRIN2A* 0.997 Neural receptor for N-methyl-D-aspartate Cell-surface receptors HIF1A 3.717 Hypoxia-inducible factor Transcription factors and their modulators HMGN1 0.910 High mobility group 14 Miscellaneous HSP90AA1 3.159 Heat shock protein Stress response genes 1 The indicated NF-kB targets are from publicly available resource in the Gilmore laboratory, Biology Department, Boston University. (http://www.bu.edu/nf-kb/gene-resources/target- genes/) * Indicates that the gene has a kB site in the promoter but has not clearly been shown to be controlled by NF-kB; or the gene expression is associated with increased NF-kB activity but has not been shown to be a target directly. Supplementary Table 1 NF-B target genes1 were list on the basis of its expression was upregulated by 70% or more in -catulin-overexpressed A549 cells (continued)

Gene ID log2 Function Gene category

IER2* 1.317 TPA-inducible, Jun-like transcription factor Transcription factors and their modulators IFI44L* 1.018 Homology to microtubule aggregating protein Miscellaneous IL23A 0.739 Interleukin-23 (p19 gene) Cytokines/Chemokines and their modulators IL2RA 1.143 IL-2 receptor subunit Immunoreceptors IL8 1.316 Interleukin-8, alpha-chemokine Cytokines/Chemokines and their modulators IRF1 1.413 Interferon regulatory factor-1 Transcription factors and their modulators IRF2 1.726 Interferon regulatory factor-2 Transcription factors and their modulators JUNB 2.091 Proto-oncogene Transcription factors and their modulators KITLG 1.886 Mast Cell Growth Factor Growth factors, ligands, and their modulators KLF10* 4.097 TGF-b early response gene; zinc finger protein Early response genes KLK3 1.050 Serum protein in Miscellaneous; Prostate-specific antigen LGALS3 1.044 b-galactosidase-binding lectin Miscellaneous; Galectin 3 MADCAM1 1.818 Mucosal addressin cell adhesion molecule Cell adhesion molecules MYB 1.130 Proto-oncogene Transcription factors and their modulators MYC 1.193 Proto-oncogene Transcription factors and their modulators MYLK 1.036 (Long) Myosin light chain kinase Enzymes MYOZ1 1.496 Muscle cell calcineurin-interacting protein Miscellaneous NFKB1 0.878 NF-kB p105 precursor Transcription factors and their modulators NFKB2 1.392 NF-kB p100 precursor Transcription factors and their modulators NR3C1* 2.819 Promoter 1B of the GR Transcription factors and their modulators NR4A2 3.876 Nuclear orphan receptor Transcription factors and their modulators NRG1 1.482 Neuregulin Growth factors, ligands, and their modulators PDE7A* 2.410 Phosphodiesterase 7A1 Enzymes PDGFB 1.540 Platelet-derived Growth Factor Growth factors, ligands, and their modulators Transcription factors and their modulators; PGR 2.662 Transcription factor Progesterone receptor PIGF 2.222 Placenta Growth Factor Growth factors, ligands, and their modulators PIK3CA 3.370 Phosphatidylinositol 3-kinase catalytic subunit Enzymes PTAFR 1.324 Platelet activator receptor Cell-surface receptors PTPN1 1.072 Protein tyrosine phosphatase 1B Enzymes PTPN13* 3.589 Protein phosphatase Regulators of apoptosis PTS* 2.146 6-pyruvoyl-tetrahydropterin synthase Miscellaneous RBBP4 2.903 Retinoblastoma-associated protein 48 Miscellaneous RELB 0.840 Transcription factor Transcription factors and their modulators REV3L* 4.621 DNA polymerase zeta Enzymes RIPK2* 2.645 Adaptor Miscellaneous SENP2 2.405 SUMO-specific protease Stress response genes SERPINE2 2.185 Serine protease inhibitor Miscellaneous SKP2 3.271 S-phase kinase-associated protein 2 Miscellaneous SLC11A2 1.593 Divalent metal ion transporter Miscellaneous SLC16A1 1.855 Monocarboxylate transporter isoform 1 Miscellaneous SLC6A6 1.535 Taurine Uptake Transporter Miscellaneous SPP1 1.173 Osteopontin Growth factors, ligands, and their modulators ST6GAL1 1.109 Sialyltransferase Enzymes TACR1 1.221 Neurokinin-1 Receptor Growth factors, ligands, and their modulators TIFA* 2.068 TRAF2 binding protein Regulators of apoptosis TNFAIP3 2.375 TNF-inducible zinc finger Transcription factors and their modulators TNFSF13B 1.142 B-cell Activating Factor Cytokines/Chemokines and their modulators TRPC1 4.204 Thrombin activation of protease-activated receptor-1 Miscellaneous TWIST1 1.214 Transcription repressor Transcription factors and their modulators VEGFC 1.456 Vascular Endothelial Growth Factor Growth factors, ligands, and their modulators XDH* 1.114 Oxidative metabolism of purines Enzymes XIAP 2.185 X-linked inhibitor of apoptosis Regulators of apoptosis YY1 1.638 Transcription factor Transcription factors and their modulators