Full Text PDF[1M]
Fundamental Toxicological Sciences (Fund. Toxicol. Sci.) 7 Vol.1, No.1, 7-13, 2014 Original Article Edematogenic and myotoxic activities induced by snake venom of Philodryas nattereri from the Northeast of Brazil Marinetes Dantas de Aquino Nery1, Hermano Damasceno de Aquino1, Rayane de Tasso Moreira Ribeiro2, Erik de Aquino Nery3, Dalgimar Beserra de Menezes4, Rafael Matos Ximenes5, Arislete Dantas de Aquino6, Lia Belchior Mendes Bezerra7, Natacha Teresa Queiroz Alves8 and Helena Serra Azul Monteiro8 1Department of Biology, Federal University of Ceará, 60455-760, Fortaleza, Ceará, Brazil 2Institut of Biosciences, University of São Paulo, São Paulo, São Paulo, Brazil 3General Hospital of Fortaleza, Fortaleza, Ceará, Brazil 4Departament of Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil 5Department of Antibiotics, Federal University of Pernambuco, Recife, Pernambuco, Brazil 6Department of Chemical Engineering, Federal University of Paraná, Curitiba, Paraná, Brazil 7Messejana Hospital, Fortaleza, Ceará, Brazil 8Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil (Received July 27, 2014; Accepted August 4, 2014) ABSTRACT — Philodryas nattereri is distributed in arid and semiarid regions of South America and is most common in northeastern Brazil. The aims of the work were to investigate the edematogenic and myotoxic effects promoted by P. nattereri venom. In this work, mice weighing 20-30 g (n = 4 for each experimental group) were used. For the edematogenic activity mice were injected in the subplantar region of the right foot pad with 50 μL of solutions containing different amounts of venom (3 and 10 μg) meas- ured by plethysmometry at 0.5, 1, 2, 3, 6, 12 and 24 hr and pretreated with indomethacin, dexamethasone and antibothropic serum, whereas the left foot pad was injected with 50 μL of NaCl 0.15 M.
[Show full text]