Curriculum Vitae: Saurabh Chatterjee, Ph.D. Education
2006: Ph.D. in Life Sciences University of Mumbai, India 1997: M.Sc. in Human Physiology University of Calcutta, India 1995: B.Sc. (Honors) in Human Physiology University of Calcutta, India
Professional Experience Saurabh Chatterjee, Ph.D.
Associate Professor (Tenured) 2020-Present: Adjunct Associate Professor, Department of Pathology, University of South Carolina, Microbiology and Immunology, University of South Carolina Arnold School of Public Health, School of Medicine, Columbia, SC. Department of Environmental Health 2019-Present: Research Health Scientist, US Department of Veterans Sciences, Columbia, SC. Affairs, Columbia, SC. Resident status: US Citizen 2017-Present: Adjunct Associate Professor, Department of Biological Sciences, Clemson University, Clemson, SC. 915 Greene Street, Discovery-1, Suite# 333, Columbia SC, 29208 2016-Present: Associate Professor (Tenured), University of South Carolina, ASPH, Environmental Health Sciences, Columbia, SC. 803-7778120 (Office) 919-5992278 (Cell phone) 2015-2020: Adjunct Associate Professor, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, [email protected] Columbia, SC.
Linkedin ; Research gate 2012-2016: Assistant Professor, University of South Carolina, ASPH, Chatterjee Lab Environmental Health Sciences, Columbia, SC.
2011-2012: Research Scientist (FTE), NIH/NIEHS, Division of Intramural About me______Research, Laboratory of Toxicology and Pharmacology, Dr. Chatterjee is a human physiologist with Research Triangle Park, NC specialized training in immunology. After 2011-2012: Postdoctoral fellow (under the K99 program), Division of completing his Ph.D in inflammation biology Gastroenterology, Duke University, Durham, NC (Life Sciences) at Bhabha Atomic Research Center affiliated to the University of Mumbai 2006-2011: Postdoctoral fellow NIH/NIEHS, Division of Intramural He pursued his postdoctoral work at the Research, Laboratory of Toxicology and Pharmacology, Laboratory of Pharmacology and Toxicology, Research Triangle Park, NC National Institute of Environmental Health
Sciences, NIH. Later he continued his Research Interest specialized research in chronic liver disease 1. Role of Microbiome (Liver-Gut-Brain Axis) in environment-linked at Duke Gastroenterology under the K99 NAFLD: Role of Climate Change Stressors-Harmful Algal Blooms (NIH portion of his NIH pathway to Independence funding received in 2018) Award. He has made significant contributions to the field of host microbiome 2. Microbiome alterations, gut-brain axis and Gulf War Illness and chronic multi-symptom illness Pathology (DOD funding received in 2018) interactions with redox biology, neuroimmune pathology and gut-brain 3. Exploring oxidative stress-epigenome signaling in obesity associated interactions in pro-inflammatory disease inflammatory liver diseases following environmental toxin and Gulf War processes like Gulf War illness, chronic and neuroimmune pathology (VA Merit funding received in 2019) multi-symptom illnesses and brain 4. Exploring the role of pattern recognition receptors (TLRS and NALP3) manifestations of liver diseases, drug and Damage Associated Molecular Patterns in toxicity associated discovery and gut-brain directed nonalcoholic steatohepatitis and neuroinflammation. therapeutics. He has been continually 5. Modulation of Nonalcoholic Fatty Liver disease (NAFLD) by alternative funded by NIH, DOD and the VA. Total: medicinal compounds (NIH funding received in 2014 and in 2018)
$7,564,895 million Extramural: $7,300,895; 6. Gut-Microbiome-Directed Therapeutics -Clinical Trial NIH (P20, P01), DOD (IIRFA), VA (Merit) (VA Merit funding received in 2021) grants.
Curriculum Vitae: Saurabh Chatterjee, Ph.D.
Grantsmanship
A: Grants and Contracts Received: Completed/Active
Total Amount and Start End Project Title Role Sponsor Share of Year Year Funding Free Radical mechanisms of environmental PI NIH/NIEHS (R00) $749,000 2012 2017 potentiation of hepatotoxicity (completed) CAM Center for Epigenetic Regulation of *Project NIH/NCC/AM $8 million; 2014 2020 Inflammation (Project 4). PI P01AT003961 Chatterjee "Sparstolonin B as a TLR antagonist in Share suppression of liver inflammation through $865,000 Epigenetic mechanisms" Under No- Cost Department of Defense, Gulf War Research PI DOD/CDMRP W81XWH- extension$26,895 2017 2018 Consortium Pilot Funding: 13-2-0072 IIFRA Department of PI DOD/CDMRP $ 1,002,520 2018 2022 Defense W81XWH1810374-02
NIH/NIEHS, P01 OHHI Center Grant *Project NIH: $ 1,425,000 2018 2023 PI 5P01ES028942-02-5262 NIH/NIGMS, P20, Inflammation and *Project NIH: $ 1,125,000 2018 2023 Epigenetics PI 5P20GM10364107-5993
VA Merit Award (CSRD) PI Department of $ 2,422,000 2019 2023 RFA: BX-18-007/CX-18-013 Veterans Affairs 1 I01 CX001923-01 VA Merit Award (CSRD) PI Department of Veterans $ 2,529,000 2022 2027 RFA: CX-21-013 Affairs NIH K01 (PI: Dr. Shuo Xiao) USC NIEHS $ 487,000 2018 2021 Mentor (No cost to Mentor) USC VPR ASPIRE I PI U of SC internal $ 15,000 2013 2014
USC VPR ASPIRE I PI U of SC internal $ 15,000 2014 2015
USC Smart State Center Co-I U of SC internal $ 10,000/year 2018 Present PI: Mitzi Nagarkatti USC Center for Teaching PI USC CTE $ 800 2018 2019 Excellence Pedagogy Grant *NIH Project PIs are independent PIs with induvial R01 like projects and are peer-reviewed in the same criteria as R01 projects. Blue: Funding obtained 2012-2016; Brown: Funding obtained 2016-2019; Peach: Funding obtained via internal mechanisms. P01 grants and the VA merit had 5-7% budget cuts in year 2 due to federal policies and the PI is not involved in the funding amount decisions.
Curriculum Vitae: Saurabh Chatterjee, Ph.D. B: Grants/Contract Proposals (Pending)
1. Department of Defense, CDMRP/Gulf war Illness Investigator New Investigator Award, Role: Co-PI, PI: Dr. Ratanesh Seth Total Costs: $750,595 (2022-2025) 2. Department of Defense, CDMRP/Gulf war Illness Clinical Evaluation Award, Role: PI, Total Costs: $2,050,595 (2022-2026) C: Grant/Contract Proposals (Not funded):
1. Department of Defense, CDMRP/Gulf war Illness Investigator-Initiated Research Focus Award, Role: PI, Total Costs: $857,000 (2019-2022) 2. NIH R01, (Collaboration with Clemson University), Role: Co-I Total costs: $39,211 (2019-2022) 3. Department of Defense, CDMRP/Gulf war Illness Investigator New Investigator Award, Role: Chief Mentor, PI: Dr. Ratanesh Seth (Postdoc) Total Costs: $357,000 (2019-2022) 4. NIH-China Initiative R01. Drinking water disinfection byproducts, Microbiome and Human NAFLD progression. Role Co-PI; PI: Dr. Susan Richardson, Total Costs: 1,010,000 (2020-2024) 5. Department of Defense, CDMRP/Gulf war Illness Investigator New Investigator Award, Role: Co-PI, PI: Dr. Ratanesh Seth Total Costs: $701,595 (2020-2023) 6. Department of Defense, CDMRP/Gulf war Illness Research Advancement Award Role: PI, Total Costs: $879,715 (2020-2023) 7. DoD/CDMRP (GRANT13137501) special call for COVID-19 proposal. Role: PI, Total Costs: $2,270,155 (2021-2025) 8. Department of Veterans Affairs (VA)- Merit Clinical Trial (Phase-II) Role: PI, Total Costs: $3,370,464 (2021-2025)
Courses Offered
1. ENHS 660: Concepts of Environment health 2. ENHS 592: Environment-linked Inflammatory Diseases 3. ENHS 324: Environment and Obesity 4. ENHS 790: Immune and Epigenome modulations in NASH 5. ENHS 793: Molecular techniques in Toxicology
Honors and Awards (Awards are highlighted in bold) 2021: Invited speaker at the Gulf War Illness Research Advisory Council meeting on progress of Biomarkers and Therapeutics, March 10th 2021; Host Professor Lawrence Steinman, Stanford University, Member, National Academy of Sciences, USA 2019: Part of the ASPH delegation and speaker at the Symposium on Environmental and Public Health at the Nanjing Medical University, Nanjing, China, 2019 2019: Panelist and plenary speaker at the Gordon Research Conference (Water, Urbanization and Food Security, Hong University and Technology, Honkong, 2019 2019: VA merit Award, 2019, 2018: Investigator Initiated Research Focus Award, Department of Defense, 2018 2017: Invited Panelist for Ford Foundation Fellowships and Biological and Biomedical Sciences, National Academy of Sciences, United States of America, 2017-2019 2017: Invited Strategic panelist, Veterans' Administration Strategic Group on Gulf War veterans' Illnesses, 2017: Nominated for the Arnold School of Public Health Outstanding Research Award, 2017. 2016: Awarded "2016 Breakthrough Star" from the office of Vice President of Research, USC, the highest research award for Junior faculty at the University. Curriculum Vitae: Saurabh Chatterjee, Ph.D. 2016: Nominated for the Arnold School of Public Health Outstanding Research Award 2016. 2015: Elected to the Program committee of the Immunotoxicology Specialty Section, Society of Toxicology 2015: Elected as a council member and Board of Directors, Association of Scientists of Indian Origin, Society of Toxicology, 2015. 2015: Outstanding Young Investigator Award 2015, Society of Toxicology, Immunotoxicology SS, recognizing the contributions to the field of immunotoxicology in the last 10 years. 2015: Board of Publications Honorable Mention Award, Category: National Award, Society of Toxicology (3 out of 300 publications (2013-2014) 2014: ASPIRE-I (Advanced Support Program for Innovative Research Excellence) award from the office of Vice President of Research, USC, 2014 2013: ASPIRE-I award from the office of Vice President of Research, USC, 2013 2012: Fellows Award for Research Excellence (FARE), National Institutes of Health, 2012 2011: Best Postdoctoral Abstract Award, Association of Scientists of Indian Origin (ASIO), 50TH Annual Meeting of Society of Toxicology, 2011 2010: Young Investigator Award, Society for Free Radical Biology and Medicine, 2010 2010: Fellows Award for Research Excellence (FARE), National Institutes of Health, 2010 2007: Intramural Research Training Award, National Institutes of Health, 2007 2006: Research Fellowship Award, University of Brighton, UK-India Education and Research Initiative, British Council (not accepted), 2006 1997: National Scholarship, Department of Science & Technology, Government of India, 1997 1996: National Talent Scholarship, Department of Education, Government of India, 1996
Peer-reviewed Publications: My Bibliography (NCBI) ⎯ Total Career Peer-Reviewed Research Publications (2003-Present): 81; (PubMed=79) (3-in press/review) ⎯ 2 Publications are listed in PubMed as S. Chatterjee. ⎯ Publications while at USC: 2012-present: 64 (Journal Impact factors as of May 2021 and may change) ⎯ Total career citations: 4334 (Web of Science) ⎯ Career h-index: 24 (Scopus); 22 (Web of Science) o Student author: Outlined in bold, italics. o Last/Senior/Corresponding author: underlined. 1. Mondal A, Saha P, Bose D, Chatterjee S, Seth RK, Xiao S, Porter DE, Brooks B, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S. Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood brain barrier dysfunction and neurodegeneration are NLRP3 and S100B dependent. Toxicology July, 2021 (Accepted, In press). IF:4.332 . Last/Senior/Corresponding author 2. Saha P, Skidmore PT, Holland LA, Mondal A, Bose D, Seth RK, Sullivan K, Janulewicz PA, Horner R, Klimas N, Nagarkatti M, Nagarkatti P, Lim ES, Chatterjee S. Andrographolide Attenuates Gut-Brain-Axis Associated Pathology in Gulf War Illness by Modulating Bacteriome-Virome Associated Inflammation and Microglia-Neuron Proinflammatory Crosstalk. Brain Sci. 2021 Jul 9;11(7):905. doi: 10.3390/brainsci11070905, IF:3.332 . Last/Senior/Corresponding author 3. Lovin LM, Kim S, Taylor RB, Scarlett KR, Langan LM, Chambliss CK, Chatterjee S, Scott JT, Brooks BW Differential influences of (±) anatoxin-a on photolocomotor behavior and gene transcription in larval zebrafish and fathead minnows. Environ Sci Eur. 2021;33(1):40. doi: 10.1186/s12302-021-00479-x. Epub 2021 Mar 30. PMID: 34367861 4. Chatterjee.S, Bose, D., Seth R., Host Gut Microbiome and current state of therapeutics in Gulf War Veterans' Illnesses: A short review. Life Sciences (Elsevier), 2021, IF- 5.02 First/Senior/Corresponding author 5. Abdulla OA, Neamah W, Sultan M, Chatterjee S, Singh N, Nagarkatti M, Nagarkatti P. AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response. Front Immunol. 2021 Feb 19;12:635903. doi: 10.3389/fimmu.2021.635903. eCollection 2021. PMID: 33679792; IF: 6.429; Curriculum Vitae: Saurabh Chatterjee, Ph.D. 6. Bose D, Saha P, Mondal A, Fanelli B, Seth RK, Janulewicz P, Sullivan K, Lasley S, Horner R, Colwell RR, Shetty AK, Klimas N, Chatterjee S. Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model. Nutrients. 2020 Sep 10;12(9):2764. doi: 10.3390/nu12092764. PMID: 32927823; PMCID: PMC7551189. IF: 4.546. Last/Senior/Corresponding author 7. Sarkar S, Saha P, Seth RK, Mondal A, Bose D, Kimono D, Albadrani M, Mukherjee A, Porter DE, Scott GI, Xiao S, Brooks B, Ferry J, Nagarkatti M, Nagarkatti P, Chatterjee S. Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Dec;238:108854. doi: 10.1016/j.cbpc.2020.108854. Epub 2020 Aug 8. IF: 2.892. Last/Senior/Corresponding author 8. Bose D, Punnag Saha, Kimono D, Ratanesh K. Seth, Ayan Mondal, Patricia Janulewicz, Kimberly Sulivan, Stephen Lasley, Ronnie Horner, Nancy Klimas, Chatterjee S. TLR Antagonism by Sparstolonin B alters microbial signature and modulates gastrointestinal and neuronal inflammation in Gulf War Illness preclinical model. Brain Sci. 2020 Aug 8;10(8). doi: 10.3390/brainsci10080532. IF:3.332 . Last/Senior/Corresponding author 9. Jiang B, Kauffman AE, Li L, McFee W, Cai B, Weinstein J, Lead JR, Chatterjee S, Scott GI, Xiao S. Health impacts of environmental contamination of micro- and nanoplastics: a review. Environ Health Prev Med. 2020 Jul 14;25(1):29. doi: 10.1186/s12199-020-00870-9. IF: 2.71 . 10. Al-Badrani M, Saha P, Mondal A, Seth RK, Sarkar S, Kimono D, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Chatterjee S. Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance. Environ Toxicol Pharmacol. 2020 Jul 17;80:103457. doi: 10.1016/j.etap.2020.103457. IF: 3.292 . Last/Senior/Corresponding author 11. Mohammed A, Alghetaa H, Zhou J, Chatterjee S, Nagarkatti P, Nagarkatti M . Protective Effects of Δ9- Tetrahydrocannabinol Against Enterotoxin-induced Acute Respiratory Distress Syndrome is Mediated by Modulation of Microbiota. Br J Pharmacol. 2020 Aug 4. doi: 10.1111/bph.15226. IF: 7.730 . 12. Kimono D, Dipro Bose, Ratanesh K. Seth, Ayan Mondal, Punnag Saha, Patricia Janulewicz, Kimberly Sulivan, Stephen Lasley, Ronnie Horner, Nancy Klimas, Chatterjee S. Host Akkermensia muciniphila abundance correlates with Gulf War Illness symptom persistence via NLRP3 mediated neuroinflammation and decreased brain derived neurotrophic factor. Neurosci Insights. 2020 Jul 27;15:2633105520942480. doi: 10.1177/2633105520942480. eCollection 2020.PMID: 32832901 IF: 3.10 . Last/Senior/Corresponding author 13. Mondal A, Bose D, Saha P, Sarkar S, Seth R, Kimono D, Albadrani M, Nagarkatti M, Nagarkatti P, Chatterjee S. Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis. J Neuroinflammation. 2020 Jul 4;17(1):201. doi: 10.1186/s12974-020-01876-4. PMID: 32622362. IF: 5.861 . Last/Senior/Corresponding author 14. Scarlett KR, Kim S, Lovin LM, Chatterjee S, Scott JT, Brooks BW Global scanning of cylindrospermopsin: Critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards. Sci Total Environ. 2020 Jun 2;738:139807. doi: 10.1016/j.scitotenv.2020.139807. PMID: 32585507 IF: 6.551. 15. Wang Y, Xu J, Stanley JE, Xu M, Brooks BW, Scott GI, Chatterjee S, Zhang Q, Zelinski MB, Xiao S. A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which identifies endocrine disrupting activity of microcystins. Reprod Toxicol. 2020 Feb 1;93:118-130. IF: 3.121 16. Philip B. Busbee, Lorenzo P Menzel, Haider R. Alrafas, Nicholas Dopkins, William Becker, Kathryn Miranda, Chuanbing Tang, Chatterjee S, Udai P Singh, Mitzi Nagarkatti, Prakash Nagarkatti. Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an interleukin 22-dependent manner. JCI Insight. 2020 Jan 16;5(1):e127551. doi: 10.1172/jci.insight.127551.PMID: 31941837. IF:6.205 17. Smith J, Neupane R, McAmis W, Singh U, Chatterjee S, Raychoudhury S. Toxicity of polycyclic aromatic hydrocarbons involves NOX2 activation. Toxicol Rep. 2019 Nov 6;6:1176-1181. doi: 10.1016/j.toxrep.2019.11.006. eCollection 2019. PubMed PMID: 31763181; PMCID: PMC6861563. IF:4.143 18. Sarkar S, Alhasson F, Kimono D, Muayad Albadrani, Ratanesh K. Seth, Shuo Xiao, Dwayne E. Porter, Geoff I. Scott, Bryan Brooks, Mitzi Nagarkatti, Prakash Nagarkatti, Chatterjee S, Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via nox-2-mir21 axis, Environmental Toxicology and Curriculum Vitae: Saurabh Chatterjee, Ph.D. Pharmacology,2019,103281,ISSN1382-6689,https://doi.org/10.1016/j.etap.2019.103.IF:3.292. Last/Senior/Corresponding author 19. Kimono D, Sarkar S, Albadrani M, Seth R, Bose D, Mondal A, Li Y, Kar AN, Nagarkatti M, Nagarkatti P, Sullivan K, Janulewicz P, Lasley S, Horner R, Klimas N, Chatterjee S. (2019). Dysbiosis-Associated Enteric Glial Cell Immune- Activation and Redox Imbalance Modulate Tight Junction Protein Expression in Gulf War Illness Pathology. Frontiers in Physiology. 10. 1229. 10.3389/fphys.2019.01229. IF: 4.134 . Last/Senior/Corresponding author 20. Seth RK, Maqsood R, Mondal A, Bose D, Kimono D, Holland LA, Janulewicz Lloyd P, Klimas N, Horner RD, Sullivan K, Lim ES, Chatterjee S. Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity in Experimental Gulf War Illness. Viruses. 2019 Oct 21;11(10). pii: E968. doi: 10.3390/v11100968. PMID: 31640184 IF: 3.841 . Last/Senior/Corresponding author 21. Janulewicz PA, Seth RK, Carlson JM, Ajama J, Quinn E, Heeren T, Klimas N, Lasley SM, Horner RD, Sullivan K, Chatterjee S. The Gut-Microbiome in Gulf War Veterans: A Preliminary Report. Int J Environ Res Public Health. 2019 Oct 4;16(19). pii: E3751. doi: 10.3390/ijerph16193751. PMID:31590322. IF:2.849 . Last/Senior/Co-Corresponding author 22. Neamah WH, Singh NP, Alghetaa H, Abdulla OA, Chatterjee S, Busbee PB, Nagarkatti M, Nagarkatti P. AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes. J Immunol. 2019 Oct 1;203(7):1830-1844. doi: 10.4049/jimmunol.1900291. Epub 2019 Sep 6. IF:4.886 . 23. Wang Y, Liu M, Johnson SB, Yuan G, Arriba AK, Zubizarreta ME, Chatterjee S, Nagarkatti M, Nagarkatti P, Xiao S. Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation. Toxicol Appl Pharmacol. 2019 Oct 15;381:114714. doi: 10.1016/j.taap.2019.114714. Epub 2019 Aug 19. PMID: 31437492. IF:3.347 24. Albadrani M, Seth RK, Sarkar S, Kimono D, Mondal A, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Jule Y, Diehl AM, Chatterjee S. Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G408-G428. doi: 10.1152/ajpgi.00061.2019. Epub 2019 Aug 8. PMID: 31393787. IF:3.725. Last/Senior/Corresponding author 25. Sarkar S, Kimono D, Albadrani M, Seth RK, Busbee P, Alghetaa H, Porter DE, Scott GI, Brooks B, Nagarkatti M, Nagarkatti P, Chatterjee S. Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease. Sci Rep. 2019 Jun 19;9(1):8742. doi: 10.1038/s41598-019-450091. IF:3.998 . Last/Senior/Corresponding author 26. Kadhim S, Singh NP, Zumbrun EE, Cui T, Chatterjee S, Hofseth L, Abood A, Nagarkatti P, Nagarkatti M. Resveratrol- Mediated Attenuation of Staphylococcus aureus Enterotoxin B-Induced Acute Liver Injury Is Associated With Regulation of microRNA and Induction of Myeloid-Derived Suppressor Cells. Front Microbiol. 2018 Dec 17;9:2910. doi: 10.3389/fmicb.2018.02910. eCollection 2018. IF: 4.076 27. Alharris E, Alghetaa H, Seth R, Chatterjee S, Singh NP, Nagarkatti M, Nagarkatti P. Resveratrol Attenuates Allergic Asthma and Associated Inflammation in the Lungs Through Regulation of miRNA-34a That Targets FoxP3 in Mice. Front Immunol. 2018 Dec 20;9:2992. IF: 6.429 28. Dattaroy D, Seth RK, Sarkar S, Kimono D, Albadrani M, Chandrashekaran V,Hasson FA, Singh UP, Seth RK, Scappinie E, Tucker JC, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B (SSnB) attenuates liverfibrosisvia a parallel conjugate pathway involving P53-P21 axis, TGF-betasignaling and focal adhesion that is TLR4 dependent. Eur J Pharmacol. 2018 Sep 5.pii: S0014-2999(18)30503-X. doi: 10.1016/j.ejphar.2018.08.040. [Epub ahead ofprint] PubMed PMID: 30194936. IF: 3.170. Last/Senior/Corresponding author 29. Seth RK, Kimono D, Alhasson F, Sarkar S, Albadrani M, Lasley SK, Horner R, Janulewicz P, Nagarkatti M, Nagarkatti P, Sullivan K, Chatterjee S. Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness. Toxicol Appl Pharmacol. 2018 Jul 1;350:64-77. doi:10.1016/j.taap.2018.05.006. Epub 2018 May 9. PubMed PMID: 29751049PubMedCentral PMCID: PMC6121708. IF:3.705 . Last/Senior/Corresponding author 30. Alhasson F, Seth RK, Sarkar S, Kimono DA, Albadrani MS, Dattaroy D, Chandrashekaran V, Scott GI, Raychoudhury S, Nagarkatti M, Nagarkatti P, DiehlAM, Chatterjee S. High circulatory leptin mediated NOX-2-peroxynitrite-miR21 Curriculum Vitae: Saurabh Chatterjee, Ph.D. axisactivate mesangial cells and promotes renal inflammatory pathology innonalcoholic fatty liver disease. Redox Biol. 2018 Jul;17:1-15. doi:10.1016/j.redox.2018.04.002. Epub 2018 Apr 7. PubMed PMID: 29660503;PubMedCentral PMCID: PMC6006523. IF:9.986 . Last/Senior/Corresponding author 31. Alghetaa H, Mohammed A, Sultan M, Busbee P, Murphy A, Chatterjee S, Nagarkatti M, Nagarkatti P. Resveratrol protects mice against SEB-induced acute lung injury and mortality by miR-193a modulation that targets TGF-β signalling.J Cell Mol Med. 2018 Mar 7. doi: 10.1111/jcmm.13542. IF: 4.688 32. Kenne GJ, Gummadidala PM, Omebeyinje MH, Mondal AM, Bett DK, McFadden S, Bromfield S, Banaszek N, Velez- Martinez M, Mitra C, Mikell I, Chatterjee S, Wee J, Chanda A. Activation of Aflatoxin Biosynthesis Alleviates Total ROS in Aspergillus parasiticus. Toxins (Basel). 2018 Jan 29;10(2). pii: E57. doi: 10.3390/toxins10020057. IF: 3.531 33. Gängler S, Charisiadis P, Seth R, Chatterjee S, Makris KC. Time of the day dictates the variability of biomarkers of exposure to disinfection byproducts. Environ Int. 2017 Dec 13;112:33-40. doi: 10.1016/j.envint.2017.12.013. [Epub ahead of print] . IF: 7.577 34. Chandrashekaran V, Seth RK, Dattaroy D, Alhasson F, Ziolenka J, Carson J, Berger FG, Kalyanaraman B, Diehl AM, Chatterjee S. HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. Redox Biol. 2017 Oct;13:8-19. doi: 10.1016/j.redox.2017.05.005. Epub 2017 May 10. IF: 9.986. Last/Senior/Corresponding author 35. Chitrala KN, Guan H, Singh NP, Busbee B, Gandy A, Mehrpouya-Bahrami P, Ganewatta MS, Tang C, Chatterjee S, Nagarkatti P, Nagarkatti M. CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice. Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6. IF: 5.179 36. Alhasson F, Das S, Seth R, Dattaroy D, Chandrashekaran V, Ryan CN, Chan LS, Testerman T, Burch J, Hofseth LJ, Horner R, Nagarkatti M, Nagarkatti P, Lasley SM, Chatterjee S. Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation. PLoS One. 2017 Mar 22;12(3):e0172914. doi: 10.1371/journal.pone.0172914. eCollection 2017. IF: 2.74 Last/Senior/Corresponding author 37. Seth RK, Das S, Dattaroy D, Chandrashekaran V, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM5, Bell PD, Liedtke W , Chatterjee S. TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. Free radical Biology and Medicine, 2016 IF: 6.17. Last/Senior/Corresponding author 38. Shamran H1, Singh NP1, Zumbrun EE1, Murphy A1, Taub DD2, Mishra MK3, Price RL4, Chatterjee S, Nagarkatti M1, Nagarkatti PS1, Singh UP6. Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation. Brain Behav Immun. 2016 Jun 17. pii: S0889-1591(16)30188-X. doi: 10.1016/j.bbi.2016.06.008. IF: 6.306. 39. Makris KC, Andrianou, XD, Pantelis Charisiadis P, Burch JB, Seth RK, Androniki Ioannou A, Michael Picolos M, Costas Christophi C, and Chatterjee S. Association between exposures to brominated trihalomethanes, hepatic injury and type II diabetes mellitus.Environ Int. 2016 May 9;92-93:486-493. doi: 10.1016/j.envint.2016.04.012. IF: 7.577. Last/Senior/Co-Corresponding author 40. Kaur K, Fayad R, Saxena A, Frizzell N, Chanda A, Das S, Chatterjee S, Hegde S, Baliga MS, Ponemone V, Rorro M, Greene J, Elraheb Y, Redd AJ, Bian J, Restaino J, Norris LB, Qureshi ZP, Love BL, Brookstaver B, Georgantopoulos P, Sartor O, Raisch DW, Rao G, Lu K, Ray P, Hrusheshky W, Schulz R, Ablin R, Noxon V, Bennett CL; Southern Network on Adverse Reactions (SONAR) project. Fluoroquinolone-related neuropsychiatric and mitochondrial toxicity: a collaborative investigation by scientists and members of a social network.J Community Support Oncol. 2016 Feb;14(2):54-65. doi: 10.12788/jcso.0167.PMID:26955658 IF: 0.34. 41. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Chatterjee S………(many authors) et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. No abstract available. IF: 9.77. 42. Dattaroy D, Seth RK; Chandrashekaran V; Das S; Alhasson F; Michelotti GA; Fan D, Nagarkatti M; Nagarkatti P; Diehl AM; Chatterjee S. Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4- Curriculum Vitae: Saurabh Chatterjee, Ph.D. trafficking in lipid rafts via NADPH oxidase activation. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G510- 25. doi: 10.1152/ajpgi.00259.2015. Epub 2015 Dec 30.PMID: 26718771 IF: 3.725. Last/Senior/Corresponding author 43. Singh NP, Singh UP, Rouse M, Zhang J, Chatterjee S, Nagarkatti PS, Nagarkatti M. Dietary Indoles Suppress Delayed- Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA. J Immunol. 2015 Dec 28. pii: 1501727. IF: 4.886 44. Chandrashekaran V, Das S, Seth RK, Dattaroy D, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis. Biochim Biophys Acta. 2016 Jan;1862(1):32-45. doi: 10.1016/j.bbadis.2015.10.009. Epub 2015 Oct 22.PMID:26474534 IF: 3.422. Last/Senior/Corresponding author 45. Alhasson F, Dattaroy D, Das S., Seth R.K., Chandrasekharan V., Schnellmann R.G., Chatterjee S. NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity. Am J Physiol Renal Physiol. 2016 Jan 1;310(1):F85-F101. doi: 10.1152/ajprenal.00243.2015. Epub 2015 Oct 7.PMID: 26447219. IF: 3.191. Last/Senior/Corresponding author 46. Baig MS, Zaichick SV, Mao M, de Abreu AL, Bakhshi FR, Hart PC, Saqib U, Deng J, Chatterjee S, Block ML, Vogel SM, Malik AB, Consolaro ME, Christman JW, Minshall RD, Gantner BN, Bonini MG. NOS1-derived nitric oxide promotes NFκB transcriptional activity through inhibition of Suppressor of Cytokine Signaling (SOCS-1). J Exp Med. 2015 Sep 21;212(10):1725-38. doi: 10.1084/jem.20140654. Epub 2015 Aug 31. PMID: 26324446. IF: 11.743 47. Chatterjee S., and Das S. P2X7 receptor as a key player in oxidative stress-driven cell fate in nonalcoholic steatohepatitis. Oxid Med Cell Longev. 2015;2015:172493. doi: 10.1155/2015/172493. Epub 2015 Mar 1.PMID: 25815106; IF: 5.076. First/Senior/Corresponding author 48. Burch JM, Everson T, Seth RK, Wirth M and Chatterjee S. Exposure to Trihalomethanes and Biomonitoring for the Chronic Liver Disease Indicator, Alanine Aminotransferase, in the United States Population (NHANES 1999-2006). Sci Total Environ. 2015 Jul 15;521-522:226-34. doi: 10.1016/j.scitotenv.2015.03.050. Epub 2015 Apr 2. PMID: 25847167. IF: 6.551. Last/Senior/Co-Corresponding author 49. Narsale A, Enos R, Puppa M, Chatterjee S, Murphy AE, Fayad R, Pena M, Durstine LJ and Carson J. Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression. PLoS One. 2015 Mar 19;10(3):e0119888. doi: 10.1371/journal.pone.0119888. eCollection 2015.PMID: 25789991. IF:2.740 50. Das S, Seth RK, Dattaroy D, Alhasson F, Pourhoseini S, Nagarkatti M, Nagarkatti P, Michelotti GA, Diehl AM, Chatterjee S. NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. Am J Pathol. 2015 Jul;185(7):1944-57. doi: 10.1016/j.ajpath.2015.03.024. Epub 2015 May 16.PMID: 25989356. IF: 4.069. Last/Senior/Corresponding author 51. Dattaroy D, Pourhosseini S, Das S, Alhasson F, Seth RK, Nagarkatti M, Michelotti GA, Diehl AM, Chatterjee S. Micro RNA 21 inhibition of SMAD 7 enhances fibrogenesis via leptin mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G298-312. doi: 10.1152/ajpgi.00346.2014. Epub 2014 Dec 11.PMID: 25501551 IF: 3.725. Last/Senior/Corresponding author 52. Pourhoseini S, Seth RK, Das S, Dattaroy D, Kadiiska MB, Xie G, Nagarkatti M, Michelotti GA, Diehl AM, Chatterjee S. Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. PLoS One. 2015 Feb 6;10(2):e0116780. doi: 10.1371/journal.pone.0116780. eCollection 2015.PMID: 25658689. IF: 2.740. Last/Senior/Corresponding author 53. Seth RK, Das S, Pourhoseini S, Dattaroy D, Igwe S, Basuray J, Fan D, Michelotti GA, Diehl AM, Chatterjee S. M1 Polarization bias and subsequent NASH progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1 induced oxidative stress in obese mice. J Pharmacol Exp Ther. 2015 Jan;352(1):77-89. doi: 10.1124/jpet.114.218131. Epub 2014 Oct 27.PMID: 25347994, IF: 3.867. Last/Senior/Corresponding author 54. Jia X, Iwanowycz S, Wang J, Saaoud F, Yu F, Wang Y, Hu J, Chatterjee S, Wang Q, Fan D., Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides. Exp Biol Med (Maywood). 2014 Aug;239(8):1025-1035. doi: 10.1177/1535370214530247. Epub 2014 Apr 16.PMID: 24740873. IF: 3.139 55. Seth RK, Das S, Kumar A, Chanda A, Kadiiska MB, Michelotti G, Manautou J, Diehl AM and Chatterjee S. CYP2E1- Dependent and Leptin-Mediated Hepatic CD57 Expression on CD8+ve T Cells aid Progression of Environment-Linked Nonalcoholic Steatohepatitis" has been received for consideration in Toxicology and Applied Pharmacology. Toxicol Curriculum Vitae: Saurabh Chatterjee, Ph.D. Appl Pharmacol. 2014 Jan 1;274(1):42-54. doi: 10.1016/j.taap.2013.10.029. Epub 2013 Nov 7.PMID: 24211274. IF: 3.705. Last/Senior/Corresponding author 56. Das S, Seth RK, Kumar A, Kadiiska MB, Michelotti G, Diehl AM and Chatterjee S. Purinergic Receptor X7 is a Key Modulator of Metabolic Oxidative Stress- Mediated Autophagy and Inflammation in Experimental Nonalcoholic Steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G950-63. doi: 10.1152/ajpgi.00235.2013. Epub 2013 Oct 24.PMID: 24157968. IF: 3.725. Last/Senior/Corresponding author 57. Miriyala S, Panchatcharam M, Landar A, Ramanujam M, Chatterjee S, Muthuswamy A. The janus of oxidative stress signaling in different pathophysiological conditions. Oxid Med Cell Longev. 2013 doi: 10.1155/2013/708796. Epub 2013 Jun 19. IF:5.076 58. Gomez-Mejiba SE, Zhai Z, Della-Vedova MC, Muñoz MD, Chatterjee S, Towner RA, Hensley K, Floyd RA, Mason RP, Ramirez DC. Immuno-spin trapping from biochemistry to medicine: Advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta. 2013 May 2. doi:pii: S0304-4165(13)00194-3. IF:3.422 59. Seth RK, Kumar A, Das S, Michelotti G, Kadiiska MB, Diehl AM and Chatterjee S. Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. Toxicol Sci. (2013) 134(2):291-303 . IF: 3.703. Last/Senior/Corresponding author 60. Kumar A, Ganini D, Deterding LJ, Ehrenshaft M, Chatterjee S, Mason RP. Immuno-spin trapping of heme-induced protein radicals: Implications for heme oxygenase-1 induction and heme degradation. Free Radic Biol Med. 2013 Apr 25;61C:265-272. IF: 6.170. 61. Das S., Kumar A., Seth R., Tokar EJ., Waalkes MP., Kadiiska MB., Mason RP., Chatterjee S. Proinflammatory Adipokine Leptin Mediates Disinfection Byproduct Bromodichloromethane-induced Early Steatohepatitic Injury in Obesity. Toxicol Appl Pharmacol. 2013 Jun 15;269(3):297-306 IF: 3.705. Last/Senior/Corresponding author 62. Sinha BK, Bhattacharjee S, Chatterjee S, Jiang J, Motten AG, Kumar A, Espey MG, Mason RP. Role of nitric oxide in the chemistry and anticancer activity of etoposide (VP-16,213). Chem Res Toxicol. 2013 Mar 18;26(3):379-87. IF:3.278 63. Chatterjee S*, Ganini D, Tokar EJ, Kumar A, Das S, Corbett J, Kadiiska M, Waalkes M, Diehl AM, Mason RP. Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental nonalcoholic steatohepatitis. J Hepatol. 2013 Apr;58(4):778-84 IF: 14.679 First/Corresponding author 64. Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol. 2013 Jan 15;266(2):224-32 IF: 3.705 65. Ansenberger-Fricano K, Ganini D, Mao M, Chatterjee S, Dallas S, Mason RP, Stadler K, Santos JH, Bonini MG. The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol Med. 2013 Jan;54:116-24. IF:6.17 66. Bhattacharjee S, Chatterjee S, Jiang J, Sinha BK and Mason RP. Detection and imaging of the free radical DNA in cells- -site-specific radical formation induced by Fenton chemistry and its repair in cellular DNA as seen by electron spin resonance, immuno-spin trapping and confocal microscopy. Nucleic Acids Res. 2012 Jul;40(12):5477-86. IF:11.502 67. Chatterjee S*, Rana R, Corbett J, Kadiiska MB, Goldstein J, Mason RP. P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice. Free Radic Biol Med. 2012 May 1;52(9):1666-79. IF: 6.17, First/Corresponding author 68. Bhattacharjee S, Deterding LJ, Chatterjee S, Jiang J, Ehrenshaft M, Lardinois O, Ramirez DC, Tomer KB, and Mason RP. Site-specific radical formation in DNA induced by Cu9II)-H2O2 oxidizing system, using ESR, Immunospintrapping, LC/MS and MS/MS. Free Radic Biol Med. 2011 Jun 1;50(11):1536-45. IF: 6.17 69. Chatterjee S, Lardinois O, Bhattacharjee S, Tucker CJ, Corbett J, Deterding L, Ehrenshaft M, Bonini M.G. and Mason RP. Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radic Biol Med. 2011 Apr 15;50(8):988-99. IF: 6.17, First/Corresponding author 70. Lardinois OM, Chatterjee S, Mason RP, Tomer KB, Deterding LJ. Biotinylated Analogue of the Spin-Trap 5,5-Dimethyl- 1-pyrroline-N-oxide for the Detection of Low-Abundance Protein Radicals by Mass Spectrometry. Anal Chem. 2010 Nov 15;82(22):9155-8. IF: 6.785 Curriculum Vitae: Saurabh Chatterjee, Ph.D. 71. Ranguelova K, Chatterjee S, Ehrenshaft M, Ramirez DC, Kadiiska M and Ronald P. Mason. Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite. J Biol Chem. 2010 Jul 30;285(31):24195-20. IF: 4.238 72. Chatterjee S*, Lardinois O, Bonini MG, Bhattacharjee S, Stadler K, Corbett J, Deterding L, Kadiiska M, Tomer KB and Mason RP. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol. 2009 Sep 15;183(6):4055-66 IF: 4.886, First/Corresponding author 73. Shukla J, Chatterjee S, Thakur VS, Premachandran S, Checker R, Poduval TB. L-Arginine reverses radiation-induced immune dysfunction: the need for optimum treatment window. Radiat Res. 2009 Feb;171(2):180-7. IF: 2.539 74. Chatterjee S*, Ehrenshaft M, Bhattacharjee S, Deterding LJ, Bonini MG, Corbett J, Kadiiska MB, Tomer KB, Mason RP. Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free Radic Biol Med. 2009 Feb 15;46(4):454-61. IF: 6.17, First/Corresponding author 75. Chatterjee S, Premachandran S, Shukla J, Poduval TB. Synergistic therapeutic potential of dexamethasone and L- arginine in lipopolysaccharide-induced septic shock. J Surg Res. 2007 Jun 1;140(1):99-108. IF: 2.187 76. Chatterjee S, Premachandran, S., Bagewadikar, RS.,Bhattacharya, S. , Chattopadhyay, S. and Poduval TB: Arginine metabolic pathways determine its therapeutic benefit in experimental heatstroke: Role of Th1/Th2 cytokine Balance. Nitric Oxide. 2006 Dec;15(4):408-16. IF: 3.311 77. Chatterjee S, Premachandran S, Sharma D, Bagewadikar RS, Poduval TB. Therapeutic treatment with L-arginine rescues mice from heat stroke-induced death: physiological and molecular mechanisms. Shock. 2005 Oct;24(4):341- 7. IF: 3.048 78. Chatterjee S, Premachandran S, Bagewadikar RS, Poduval TB. The use of ELISA to monitor amplified hemolysis by the combined action of osmotic stress and radiation: potential applications. Radiat Res. 2005 Mar;163(3):351-5. IF:2.539 79. Chatterjee S, Poduval TB, Tilak JC, Devasagayam TP. A modified, economic, sensitive method for measuring total antioxidant capacities of human plasma and natural compounds using Indian saffron (Crocus sativus). Clin Chim Acta. 2005 Feb;352(1-2):155-63. IF:2.535 80. Thakur VS, Shankar B, Chatterjee S, Premachandran S, Sainis KB. Role of tumor-derived transforming growth factor- beta1 (TGF-beta1) in site-dependent tumorigenicity of murine ascitic lymphosarcoma. Cancer Immunol Immunother. 2005 Sep;54(9):837-47 IF: 5.442 81. Poduval TB, Chatterjee S, Sainis KB. Effect of nitric oxide on mortality of mice after whole body hyperthermia. Int J Hyperthermia. 2003 Jan-Feb;19(1):35-44. IF: 3.98 Manuscripts under review/in preparation Book Chapter 1.Bose D, Chatterjee S, Older E, Seth RK, Janulewicz PA, Saha P, Mondal A, Decho A, Sullivan K, Klimas N, Lasley S, Li J, Chatterjee S. Gut resistome presents a unique biome signature in chronic multi-symptom illness patients and links persistent pro-inflammatory phenotype in a mouse model reversible by fecal microbiota transfer. Communications Biology (Nature Portfolio Journal) Jun 2021, (manuscript Under Revision). 3.Seth RK, Saha P, Bose D, Mondal A, Sullivan K, Janulewicz PA, Shetty A, O'Callaghan J, Klimas N, Chatterjee S. Ampakine CX546 ameliorate Gut-derived extracellular HMGB1 induced neurological ailment in experimental Gulf War Illness. (Manuscript under preparation) 4.Seth RK, Saha P, Bose D, Sullivan K, Janulewicz PA, Klimas N, Chatterjee S. Nexinhib 20 ameliorates hepatic extracellular HMGB1 mediated M1 polarization and liver inflammation in a mouse model of Gulf War Illness. (Manuscript under preparation)
Book Chapter
G Krishna, S Chatterjee, PA Krishna, RK Seth. Chapter 59: MicroRNA Expression as an Indicator of Tissue Toxicity and a Biomarker in Disease and Drug-Induced Toxicological Evaluation. Biomarkers in Toxicology (2nd Edition) 2019, 1047- 1072. https://doi.org/10.1016/B978-0-12-814655-2.00059-1 Curriculum Vitae: Saurabh Chatterjee, Ph.D.
Peer Reviewed Journal Conference Proceedings -Abstracts (Students and Postdocs):
List of Major Scientific Presentations, conference abstracts by students and postdocs (National and International conferences are marked by asterisks): 2012-2021 (2020 presentations were cancelled due to COVID19 however the abstracts were published).
1. Das S., Seth R.K., Kadiiska M.B. and Chatterjee S. Free Radical Metabolism Promotes Autophagy in Environment- Associated Steatohepatitic Lesions. North Carolina Society of Toxicology Regional Chapter; Spring meeting - February 21, 2013 at the U.S. EPA in Research Triangle Park. 2. Seth R.K., Kumar A., Das S., Kadiiska M.B., Tokar E.J., Waalkes M.P., Michelotti G., Diehl A.M. and Chatterjee S. Cytochrome P450 2E1, modulates disinfection byproduct bromodichloromethane induced Nonalcoholic Steatoheaptitis. North Carolina Society of Toxicology Regional Chapter; Spring meeting - February 21, 2013 at the U.S. EPA in Research Triangle Park 3. **Das S., Kumar A., Ganini D., Tokar E.J., Corbett J., Kadiiska M., Waalkes M., Diehl A.M., Mason R.P. and Chatterjee S. Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic stetatohepatitis. SOT-2013; 52nd Annual Meeting at San Antonio, Texas. March, 10-14: 2013. The toxicologist (Suppl to Toxicological Sciences),2013; 132 (1); 138. 4. **Seth R.K., Kumar A., Das S., Kadiiska M., Tokar E.J., Waalkes M., Michelotti G., Diehl A.M., and Chatterjee S. Chronic Exposure of Disinfectant Byproduct Bromodichloromethane Causes Nonalcoholic Steatoheaptitis, a Hepatic Manifestation of the Metabolic Syndrome. SOT-2013; 52nd Annual Meeting at San Antonio, Texas. March, 10-14: 2013. 2013 Annual Meeting Abstract Supplement (Suppl to Toxicological Sciences), page 34. 5. Das S., Seth R.K., Kadiiska M.B. and Chatterjee S. Exposure to Drinking Water Contaminants Promotes Autophagy in NASH of Obesity: It Takes Two to Tango! (Oral presentation at the Graduate Student Day of the University of South Carolina held on April 12, 2013 in USC, Columbia, South Carolina). 6. **Seth, R.K., Kumar, A., Das, S., Kadiiska, M.B., Michelotti, G., Diehl, A.M. and Chatterjee, S. Environmental Toxin-Linked Nonalcoholic Steatohepatitis and Hepatic Metabolic Reprogramming in Obese Mice. Gordon Research Conference on Cellular & Molecular Mechanisms of Toxicity, Proctor Academy in Andover NH United States. Aug 11-16:2013 7. **Seth, R.K., Das, S., Kumar, A., Chanda A., Kadiiska, M.B., Michelotti, G., Diehl, A.M. and Chatterjee, S. CYP2E1- dependent and Leptin-induced CD57-positive cytotoxic T cells are crucial for progression of nonalcoholic steatohepatitis. The Liver meeting 2013: The 64th Annual Meeting of the American Association for the Study of Liver Diseases at Washington DC. November 1-5, 2013. Hepatology, 2013; 58 (S1); 538A 8. **Das, S., Seth, R.K., Kumar, A., Kadiiska, M.B., Michelotti, G., Diehl, A.M. and Chatterjee, S. Purinergic receptor X7 is a Key Modulator of Metabolic Oxidative Stress-Mediated Autophagy and Inflammation in Experimental Non- alcoholic Steatohepatitis. The Liver meeting 2013: The 64th Annual Meeting of the American Association for the Study of Liver Diseases at Washington DC. November 1-5, 2013. Hepatology, 2013; 58 (S1); 538A 9. **Das, S., Seth, R.K., Michelotti, G., Diehl, A.M. and Chatterjee, S. Hepatic Vascular Endothelial Dysfunction in Environmental Toxin-Induced Nonalcoholic Steatohepatitis Is Regulated by TLR4-miR21- GRHL3 Axis. Henry M. and Lillian Stratton Basic Research Single Topic conference (AASLD): 'Non- coding RNAs in Liver Disease' at Miami, Florida, on March 8, 2014 10. **Das, S., Seth, R.K., Michelotti, G., Diehl, A.M. and Chatterjee, S. Hepatic Vascular Endothelial Dysfunction in Environmental Toxin-Induced Nonalcoholic Steatohepatitis Is Regulated by TLR4-miR21- GRHL3 Axis. SOT-2014; 53rd Annual Meeting at Phoenix, Arizona. March, 23-27: 2014. The Toxicologist (Suppl to Toxicological Sciences), 2014; 138 (1); 313-314. Curriculum Vitae: Saurabh Chatterjee, Ph.D. 11. **Seth, R.K., Das, S., Kumar, A., Chanda A., Kadiiska, M.B., Michelotti, G., Manautou, J.E., Diehl, A.M. and Chatterjee, S. Leptin Mediated CD57 Expression on CD8+ve Cytotoxic T Cells Are Crucial for Toxicity-Induced Nonalcoholic Steatohepatitis. SOT-2014; 53rd Annual Meeting at Phoenix, Arizona. March, 23-27: 2014. The Toxicologist (Suppl to Toxicological Sciences), 2014; 138 (1); 535. 12. Das, S., Seth, R.K., Michelotti, G., Diehl, A.M. and Chatterjee, S. Hepatic Vascular Endothelial Dysfunction in Environmental Toxin-induced Nonalcoholic Steatohepatitis is regulated by TLR4-miR21- GRHL3 axis. University of South Carolina Graduate Student Day Oral presentation, at USC Columbia Campus, South Carolina, in April 2014. 13. Pourhosseini, S., Seth, R.K., Das, S., Kadiiska, M.B., Michelotti, G., Nagarkatti, M., Diehl, A.M. and Chatterjee, S. Novel upregulation of miR21 and repression of its target protein GRHL3 by leptin is strongly associated with sinusoidal endothelial dysfunction and nonalcoholic steatohepatitis progression in obese mice. University of South Carolina Graduate Student Day Oral presentation, at USC Columbia Campus, South Carolina, in April 2014. 14. Das, S., Seth, R.K., Pourhosseini, S., Dattaroy, D., Alhasson, A., Nagarkatti, M., Michelotti, G., Diehl, A.M. and Chatterjee, S. TLR4 Recruitment in Hepatic Lipid Rafts following BDCM-Exposure: Role of Redox Signaling in NASH progression. Vernberg Lecture Series at Arnold School of Public Health, USC in October 2014. 15. Seth, R.K., Das, S., Kumar, A., Chanda A., Kadiiska, M.B., Michelotti, G., Manautou, J.E., Diehl, A.M. and Chatterjee, S. Leptin Mediated CD57 Expression on CD8+ve Cytotoxic T Cells Are Crucial for Toxicity-Induced Nonalcoholic Steatohepatitis. Vernberg Lecture Series at Arnold School of Public Health, USC in October 2014. 16. Pourhosseini, S., Seth, R.K., Das, S., Dattaroy, D., Kadiiska, M.B., Michelotti, G., Nagarkatti, M., Diehl, A.M. and Chatterjee, S. Mir21-induced sinusoidal injury following disinfection byproduct toxicity in obesity. Vernberg Lecture Series at Arnold School of Public Health, USC in October 2014. 17. Dattaroy, D., Pourhosseini, S., Das, S., Alhasson, A., Seth, R.K., Michelotti, G., Nagarkatti, M., Diehl, A.M. and Chatterjee, S. Mechanisms of environmental toxin-induced fibrogenesis in fatty liver disease. Vernberg Lecture Series at Arnold School of Public Health, USC in October 2014. 18. **Dattaroy, D., Seth, R.K., Das, S., Pourhosseini, S., Nagarkatti, M., Michelotti, G., Diehl, A.M. and Chatterjee, S. Micro RNA 21 inhibition of SMAD 7 enhances fibrogenesis via leptin mediated NADPH oxidase in experimental nonalcoholic steatohepatitis. The Liver meeting 2014: The 65th Annual Meeting of the American Association for the Study of Liver Diseases at Boston , MA. November 7-11, 2014. Hepatology, 2014; 60 (S1); 249A 19. **Seth, R.K., Das, S., Pourhosseini, S., Dattaroy, D., Igwe, S., BasuRay, J., Michelotti, G., Diehl, A.M. and Chatterjee, S. M1 Polarization bias and subsequent NASH progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1 induced oxidative stress. The Liver meeting 2014: The 65th Annual Meeting of the American Association for the Study of Liver Diseases at Boston , MA. November 7-11, 2014. Hepatology, 2014; 60 (S1); 762A 20. **Das, S., Seth, R.K., Pourhosseini, S., Dattaroy, D., Alhasson, A., Nagarkatti, M., Michelotti, G., Diehl, A.M. and Chatterjee, S. NADPH oxidase-induced TLR4 recruitment to hepatic lipid rafts mediates NASH progression. The Liver meeting 2014: The 65th Annual Meeting of the American Association for the Study of Liver Diseases at Boston , MA. November 7-11, 2014. 21. **Seth, R.K., Das, S., Pourhosseini, S., Dattaroy, D., Igwe, S., BasuRay, J., Fan. D., Michelotti, G., Diehl, A.M. and Chatterjee, S. M1 Polarization Bias and Subsequent Toxicity-Induced NASH Progression Is Attenuated by Nitric Oxide Donor DETA NONOate. SOT-2015; 54th Annual Meeting at San Diego, CA. March, 22-26: 2015. Abstract# 147 22. **Pourhosseini, S., Seth, R.K., Dattaroy, D., Das, S., Alhasson, F., Nagarkatti, M., Michelotti, G., Diehl, A.M. and Chatterjee, S. miR21 facilitated cyclin D1 protein surge is crucial for leptin mediated fibrogenesis in disinfection byproduct (DBP) -induced hepatotoxicity. SOT-2015; 54th Annual Meeting at San Diego, CA. March, 22-26: 2015. Abstract # 157 23. **Dattaroy, D., Pourhosseini, S., Das, S., Alhasson, F., Seth, R.K., Nagarkatti, M., Michelotti, G., Diehl, A.M. and Chatterjee, S. Mechanism of environmental toxin induced fibrogenesis in fatty liver disease. SOT-2015; 54th Annual Meeting at San Diego, CA. March, 22-26: 2015. Abstract# 122 Curriculum Vitae: Saurabh Chatterjee, Ph.D. 24. **Das, S., Seth, R.K., Pourhoseini, S., Dattaroy, D., Alhasson, F., Nagarkatti, M., Michelotti, G., Diehl, A.M. and Chatterjee, S. "Redox Signaling-Induced TLR4 Activation Is Crucial for Disinfection Byproduct (DBP)-Mediated NASH Progression". SOT-2015; 54th Annual Meeting at San Diego, CA. March, 22-26: 2015. Abstract #148. 25. **Alhasson, F., Dattaroy, D., Das, S., Seth, R.K., Pourhoseini, S., Schnellmann, R.G., Chatterjee, S. "Nonalcoholic Fatty Liver Disease Potentiates Disinfection Byproduct Induced Proximal Tubular Immunotoxicity by Mesanglial Cell Mediated Suppression of NKT Cells". SOT-2015; 54th Annual Meeting at San Diego, CA. March, 22-26: 2015. Late breaking submission 26. **Chandrashekaran, V., Das, S, Seth, R.K., Nagarkatti, P.S., Nagarkatti, M., Michelotti, G., Diehl, A.M., Chatterjee, S. "Purinergic Receptor X7 Modulates Glut4 Induction and Stellate Cell Activation Following Disinfection Byproduct-Mediated Potentiation of NAFLD". . SOT-2015; 54th Annual Meeting at San Diego, CA. March, 22-26: 2015. Late breaking submission 27. **Chandrashekaran, V., Das, S, Seth, R.K., Nagarkatti, P.S., Nagarkatti, M., Michelotti, G., Diehl, A.M., Chatterjee, S. "Purinergic Receptor X7 Modulates Glut4 Induction and Stellate Cell Activation Following Disinfection Byproduct-Mediated Potentiation of NAFLD". SOT-2015; 54th Annual Meeting at San Diego, CA. March, 22-26: 2015. Late breaking submission 28. Dattaroy, D., Seth, R.K., Das, S., Chandrashekaran, V., Alhasson, F., Michelotti, G., Fan, D., Nagarkatti, M., Nagarkatti, P.S. Diehl, A.M., and Chatterjee, S. Administration of Sparstolonin B Attenuates Early Steatohepatitic Injury. Graduate Student day, University of South Carolina, April 10, 2015. 29. Alhasson, F., Dattaroy, D., Das, S., Seth, R.K., Pourhoseini, S., Schnellmann, R.G., Chatterjee, S. "Nonalcoholic Fatty Liver Disease Potentiates Disinfection Byproduct Induced Proximal Tubular Immunotoxicity by Mesanglial Cell Mediated Suppression of NKT Cells". Graduate Student day, University of South Carolina, April 10, 2015. 30. Chandrashekaran V, Das S, Seth RK, Nagarkatti P, Nagarkatti M, Michelotti G, Diehl A, Chatterjee S. "Purinergic receptor X7 modulates GLUT4 induction and stellate cell activation following disinfection by-product mediated potentiation of NAFLD. Graduate Student day, University of South Carolina, April 10, 2015. 31. Alhasson F, Dattaroy D, Das S, Chandrashekaran V, Seth R, Schnellmann R, and Chatterjee S. "Environmental Liver Disease and ectopic glomerular dysfunction". Presented in ENHS seminar series, University of South Carolina, October 30, 2015 32. **Seth, R.K., Das, S., Dattaroy, D., Alhasson, F., Bell, D.P., Michelotti, G., Nagarkatti, M., Nagarkatti, P.S., Liedtke, W., Diehl, A.M. and Chatterjee, S. TRPV4 regulates inflammation and Kupffer cell activation in nonalcoholic steatohepatitis by attenuation of CYP2E1-mediated oxidative stress. The Liver meeting 2015: The 66th Annual Meeting of the American Association for the Study of Liver Diseases at San Francisco, CA. November 13-17, 2015 33. **Das, S., Seth, R.K., Chadrashekaran, V., Alhasson, F., Dattaroy, D., Michelotti, G., Nagarkatti, M., Nagarkatti, P.S., Bell, D.P., Liedtke, W., Diehl, A.M. and Chatterjee, S. TRPV4 deficiency enhances TLR4 recruitment to lipid rafts and exhibits exacerbated stellate cell activation and fibrosis in experimental nonalcoholic steatohepatitis. The Liver meeting 2015: The 66th Annual Meeting of the American Association for the Study of Liver Diseases at San Francisco, CA. November 13-17, 2015 34. **Dattaroy, D., Seth, R.K., Das, S., Alhasson, F., Fan, D., Nagarkatti, M., Nagarkatti, P.S. and Chatterjee, S. Sparstolinin B, a TLR4-antagonist attenuates early steatohepatitic injury in progressive nonalcoholic steatohepatitis. The Liver meeting 2015: The 66th Annual Meeting of the American Association for the Study of Liver Diseases at San Francisco, CA. November 13-17, 2015 35. **Dattaroy, D., Chandrashekaran, V., Seth, R.K., Alhasson, F., Michelotti, G., Daping F., Nagarkatti, M., Nagarkatti, P.S., Diehl, A.M. and Chatterjee, S. Sparstolonin B Attenuates Liver Fibrosis Induced By Cyp2e1 Mediated Redox Toxicity In Obese Liver. SOT-2017; 56th Annual Meeting at Baltimore, MD. March, 12-16: 2017. Curriculum Vitae: Saurabh Chatterjee, Ph.D. 36. **Seth, R.K., Dattaroy, D., Chandrashekaran, V., Alhasson, F., Michelotti, G., Nagarkatti, M., Nagarkatti, P.S., Liedtke, W., Bell, D.P., Diehl, A.M. and Chatterjee, S. TRPV4 attenuates M1 polarization and subsequent NASH progression by stalling CYP2E1-mediated redox toxicity via eNOS. Immunology 2016: The Annual Meeting of the American Association of Immunologist as Washington DC, May 12-16, 2017 37. **Chandrashekaran V, Seth RK, Dattaroy D, Alhasson F, Zielonka J, Carson J, Berger F Kalyanaraman B, Diehl AM and Chatterjee S. High mobility group box 1 (HMGB1)-RAGE interaction mediates ectopic Intestinal inflammation in NAFLD. Immunology 2016: The Annual Meeting of the American Association of Immunologist as Washington DC, May 12-16, 2017. 38. **Dattaroy, D., Chandrashekaran, V., Seth, R.K., Alhasson, F., Daping F., Nagarkatti, M., Nagarkatti, P.S., Diehl, A.M. and Chatterjee, S. Administration of Sparstolonin B- a TLR4 antagonist, attenuates hepatic fibrosis by inhibiting TLR4 mediated hepatic fibroblast proliferation. Immunology 2016: The Annual Meeting of the American Association of Immunologist as Washington DC, May 12-16, 2017. 39. **Alhasson, F; Das, S; Chandrashekaran, V; Dattaroy, D; Seth, R; Nagarkatti, M, Nagarkatti, P; Chatterjee, S. Adipokine Leptin mediated NOX-2 promotes kidney inflammation in nonalcoholic fatty liver disease via miR21 dependent mesangial cell immune activation. The Annual Meeting of the American Association of Immunologist as Washington DC, May 12-16, 2017. 40. **Alhasson, F; Chandrashekaran, V; Albadrani M; Seth, R; Nagarkatti, M, Nagarkatti, P; Chatterjee, S. Microcystin activates renal NOX2 and exacerbates nonalcoholic fatty liver disease-induced ectopic glomerulonephritis. The Society for Redox Biology and Medicine's 24th Annual Meeting (SfRBM 2017) November 29 – December 2, 2017 in Baltimore, MD, USA. 41. **Albadrani M, Alhasson, F; Dattaroy D; Chandrashekaran, V; Seth, R; Nagarkatti, M, Nagarkatti, P; Chatterjee, S. Microcystin exposure exacerbates nonalcoholic fatty liver disease (NAFLD) via NOX2 dependent activation of miR21-induced inflammatory pathways. The Society for Redox Biology and Medicine's 24th Annual Meeting (SfRBM 2017) November 29 – December 2, 2017 in Baltimore, MD, USA. 42. **Chandrashekaran, V; Johnson, S; Sarkar, S; Alhasson, F; Seth, R; Nagarkatti, M, Nagarkatti, P; Chatterjee, S. P2X7 receptor-NOX2 Axis mediates Tryptophan oxidation in murine and human non alcoholic fatty liver disease. The Society for Redox Biology and Medicine's 24th Annual Meeting (SfRBM 2017) November 29 – December 2, 2017 in Baltimore, MD, USA. 43. **D. Kimono,1 S. Sarkar,1 F. Alhasson,1 M.Albadrani,1 R. K. Seth*,1 G.Scott,1 M. Nagarkatti,2 P. Nagarkatti,2 P. Janulewicz Lloyd,3 S. Lasley,4 R. D. Horner,1 K. Sullivan,3 S. Chatterjee1;Microbial Dysbiosis In Gulf War Illness Correlates Well With Altered Metabolism And Toll Like Receptor TLR%-5 Expression That Is TLR-4 Dependent Conference: SOT 2018 San Antonio Texas 44. D. Kimono,1 s. Sarkar,1 f. Alhasson,1 m. Albadrani,1 r. K. Seth*,1 g. Scott,1 m. Nagarkatti,2 p. Nagarkatti,2 p. Janulewicz lloyd,3 s. Lasley,4 r. D. Horner,1 k. Sullivan,3 s. Chatterjee1. Gulf War illness, Cues from the silent liver; Discovery USC, University of South Carolina. Columbia. 2018, University of South Carolina 45. ** D. Kimono,1 S. Sarkar,1 F. Albadrani,1 R. K Seth,1 M. Nagarkatti,2 P. Nagarkatti,2 P. Janulewicz Lloyd,3 S. Lasley,4 R. D. Horner,1 K. Sullivan,3 N. Klimas5, S. Chatterjee Gulf war illness Virome signature and its effect on gastrointestinal inflammation, SOT 2019 Baltimore, Maryland
46. Diana Kimono. Firas Alhasson, Diptadip Dattaroy, Sutapa Sarkar, Muayad Albadrani, Ratanesh K. Seth, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterjee* SsnB Improves Outcomes In Nafld Induced Glomerular Nephritis (CAM/COBRE meeting 2018 Columbia South Carolina 47. ** M. Albadrani, F. Alhasson, D. Dattaroy, V. Chandrashekaran, R. Seth, G. I. Scott, M. Nagarkatti, P. Nagarkatti, and S. Chatterjee, Altered microbiome-enteric glial cell-NADPH oxidase axis is key to deployment-associated gastrointestinal inflammatory problems., SFRBM Chicago 2018. Curriculum Vitae: Saurabh Chatterjee, Ph.D. 48. **Diana Kimono, Sutapa Sarkar, Muayad Albadrani, Ratanesh Seth1, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sulivan, Stephen Lasley, Nancy Klimas, Saurabh Chatterjee Redox Signaling Is Key to Mir21 Mediated Potentiation Of Hepatic Immunotoxicity In Nafld Following Microcystin Exposure. Society of Toxicology Annual Meeting, held in San Antonio, Texas, March 2018. 49. **Muayad Albadrani, Firas Alhasson, Diptadip Dattaroy, Varun Chandrashekaran, Ratanesh Seth, Mitzi Nagarkatti, Prakash Nagarkatti, and Saurabh Chatterjee.Microcystin exposure exacerbates nonalcoholic fatty liver disease (NAFLD) via NOX2 dependent activation of miR21-induced inflammatory pathways. SfRBM 2017 SfRBM's 24th Annual Meeting Program and Abstracts November 29 – December 2, 2017 Hilton Baltimore Baltimore, MD USA. 50. **Sarkar S, Kimono DA, Albadrani M, Seth RK, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S. Microcystin exposure in NAFLD alters tight junction protein and modulates Paneth Cell pathology via NOX-2 activation. Society of Toxicology Annual Meeting, held in San Antonio, Texas, March 2018. 51. Sarkar S, Kimono DA, Albadrani M, Seth RK, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S Gut Feeling: An Environmental link to Non-Alcoholic Fatty Liver Disease. Carolina Society for Environmental Toxicology and Chemistry (CSETAC) Regional Meeting, held in Durham, North Carolina, April 2018. 52. Sarkar S, Kimono DA, Albadrani M, Seth RK, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S.Environmental Links to Non-Alcoholic Fatty Liver Disease DiscoverUSC, held in University of South Carolina, Columbia, South Carolina, April 2018. 53. Sarkar S, Dattaroy D, Seth RK, Kimono DA, Albadrani M, AlHassan F, Nagarkatti M, Nagarkatti P, Chatterjee S. Andrographolide attenuates fibrotic Liver Injury. COBRE Regional Meeting, held in Columbia, South Carolina, May 2018. 54. **Sarkar S, Kimono DA, Albadrani M, Seth RK, Scott GI, Porter DE, Nagarkatti M, Nagarkatti P, Chatterjee S. PP2A inhibition in NAFLD, leads to an underlying Intestinal Fibrotic Pathology that is NOX2 dependent. Society of Free Radical Biology and Medicine, held in Chicago, Illinois, November 2018. 55. **Diana Kimono, Sutapa Sarkar, Muayad Albadrani, Ratanesh Seth1, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sulivan, Stephen Lasley, Nancy Klimas, Saurabh Chatterjee. Altered microbiome-enteric glial cell-NADPH oxidase axis is key to deployment-associated gastrointestinal inflammatory problems. SfRBM 2018 - 25th Annual Conference of the Society for Redox Biology and Medicine, Chicago. Nov 15-17, 2018. 56. **Sarkar S, Kimono DA, Albadrani M, Seth RK, Scott GI, Porter DE, Nagarkatti M, Nagarkatti P, Chatterjee S. Microcystin exposure in NAFLD links ectopic intestinal fibrotic lesions: role of liver-gut crosstalk. Society of Toxicology Annual Meeting, held in Baltimore, Maryland, March 2019. 57. D. Bose, D. Kimono, S. Sarkar, M. Albadrani, A. Mondal, R. Seth, K. Sullivan, P. Janulewicz, M. Nagarkatti, P. Nagarkatti, R. Horner, N. Klimas and S. Chatterjee. Sparstolonin B, a TLR4 antagonist is a prime candidate to restore systemic inflammation and gut health in GWI mouse models in a GWI model. VISN7 3rd Annual Research Symposium at Birmingham VA Medical Center, November 14, 2019 58. P. Saha, D. Kimono, S. Sarkar, M. Albadrani, A. Mondal, R. Seth, K. Sullivan, P. Janulewicz, M. Nagarkatti, P. Nagarkatti, R. Horner, N. Klimas and S. Chatterjee. Potential therapeutic effects of Andrographolide in restoring gut-brain inflammatory surge in a mouse model of Gulf-war illness. VISN7 3rd Annual Research Symposium at Birmingham VA Medical Center, November 14, 2019. 59. D. Kimono, S. Sarkar, M. Albadrani, RK Seth, M. Nagarkatti, P. Nagarkatti, P. Janulewicz Lloyd, S. Lasley, R. D. Horner, K. Sullivan, N. Klimas, S. Chatterjee. Gulf war illness Virome signature and its effect on gastrointestinal inflammation. Military Health System Research Symposium (MHSRS) conference Aug 19-22, 2019 at Gaylord Palms Resort & Convention Center, Kissimmee, Fl. 60. Ratanesh K Seth, Ayan Mondal, Rabia Maqsood, Dipro Bose, Diana Kimono, Muayad Albadrani, LA Holland, Mitzi Nagarkatti, Prakash S. Nagarkatti, Patricia Janulewicz Lloyd, Stephen Lasley, Nancy Klimas, Ronnie D Horner, Curriculum Vitae: Saurabh Chatterjee, Ph.D. Kimberly Sullivan, Efrem S Lim, and Saurabh Chatterjee. Gut Virome-Bacteriome interplay regulate inflammatory phenotype in experimental Gulf War illness. VA Research Day Conference; Columbia SC May 29, 2019. 61. D. Bose, D. Kimono, S. Sarkar, M. Albadrani, A. Mondal, R. Seth, K. Sullivan, P. Janulewicz, S. Lasley, and S. Chatterjee. Sparstolonin B, a TLR4-Antagonist Attenuates NLRP3 Mediated Inflammasome Activation in GWI Model. VA Research Day Conference; Columbia SC May 29, 2019. 62. D. Kimono, S. Sarkar, M. Albadrani, RK Seth, M. Nagarkatti, P. Nagarkatti, P. Janulewicz Lloyd, S. Lasley, N. Klimas, R. D. Horner, K. Sullivan, S. Chatterjee. Altered microbiome induced reactive enteric glial cells contribute to gastrointestinal inflammatory phenotypes in Gulf War Illness. VA Research Day Conference; Columbia SC May 29, 2019. 63. **D. Kimono, S. Sarkar, M. Albadrani, RK Seth, M. Nagarkatti, P. Nagarkatti, P. Janulewicz Lloyd, S. Lasley, R. D. Horner, K. Sullivan, N. Klimas, S. Chatterjee. Gulf war illness Virome signature and its effect on gastrointestinal inflammation. SOT-2019; 58th Annual Meeting in Baltimore, Maryland. March 10–14, 2019. 64. P. Saha, D. Bose, D. Kimono, A. Mondal, S. Sarkar, R. Seth, K. Sullivan, P. Janulewicz, M. Nagarkatti, P. Nagarkatti, R. Horner, N. Klimas and S. Chatterjee. “Potential therapeutic effects of Andrographolide in restoring gut-brain inflammatory surge in a mouse model of Gulf-war illness” VISN7 3rd Annual Research Symposium at Birmingham VA medical Centre, Alabama, November 14, 2019. 65. **Ratanesh K Seth, Dipro Bose, Punnag Saha, Diana Kimono, Ayan Mondal, Patricia Janulewicz Lloyd, Nancy Klimas, Ronnie D Horner, Kimberly Sullivan, Efrem S Lim, Mitzi Nagarkatti, Prakash S. Nagarkatti, and Saurabh Chatterjee. Altered Gut DNA virome diversity associated HMGB1 release regulates reactive Astrocytes-induced IL6 release preferably via TLR4-NFkB pathway in experimental Gulf War Illness. AAI Annual Meeting, Honolulu, HI May 8, 2020 - May 12, 2020 66. **Ratanesh K. Seth, Dipro Bose, Punnag Saha, Diana Kimono, Sutapa Sarkar, Ayan Mondal, Muayad Albadrani, Patricia Janulewicz Lloyd, Ronnie D. Horner, James O’Callaghan, Kimberly Sullivan, and Saurabh Chatterjee. Ampakine CX546 ameliorate Gulf War agents exposure and stress-induced exosomal HMGB1 that causes neurological ailment in Experimental Gulf War Illness. SOT-2020; 59th Annual Meeting in Anaheim, California. March 15–19, 2020 67. **Ratanesh K. Seth 1, Rabia Maqsood 2, Ayan Mondal 1, Dipro Bose 1, Diana Kimono 1, LaRinda A. Holland 2, Patricia Janulewicz Lloyd 3, Nancy Klimas 4, Ronnie D. Horner 5, Kimberly Sullivan 3, Efrem S. Lim 2, and Saurabh Chatterjee 1,6 Altered Gut Virome-Bacteriome Diversity Regulate Inflammatory Phenotype and Neuronal Immunotoxicity in Experimental Gulf War Illness. SOT-2020; 59th Annual Meeting in Anaheim, California. March 15–19, 2020 68. **P. Saha1, D. Bose1, D. Kimono1, A. Mondal1, S. Sarkar1, R. Seth1, K. Sullivan2, P. Janulewicz 2, M. Nagarkatti3, P. Nagarkatti3, R. Horner4, N. Klimas5 and S. Chatterjee1. Potential therapeutic effects of Andrographolide in attenuating gut-brain inflammatory surge in a mouse model of Gulf-war illness. SOT-2020; 59th Annual Meeting in Anaheim, California. March 15–19, 2020 69. **D. Bose, D. Kimono, S. Sarkar, M. Albadrani, P. Saha, A. Mondal, R. Seth, K. Sullivan, P. Janulewicz, M. Nagarkatti, P. Nagarkatti, R. Horner, N. Klimas and S. Chatterjee. Sparstolonin B, a TLR4 Antagonist is a Prime Candidate to Combat Systemic Inflammation and Restore Gut Health in GWI Mouse Models. SOT-2020; 59th Annual Meeting in Anaheim, California. March 15–19, 2020 70. **D. Kimono, RK Seth, D. Bose, A. Mondal, P. Saha, M. Nagarkatti, P. Nagarkatti, P. Janulewicz Lloyd, S. Lasley, R. D. Horner, K. Sullivan, Nancy Klimas, S. Chatterjee. Exposure to Gulf war chemicals is associated with persistent neurological inflammation which is NLRP3 mediated. SOT-2020; 59th Annual Meeting in Anaheim, California. March 15–19, 2020 Curriculum Vitae: Saurabh Chatterjee, Ph.D. 71. **Mondal, A., Seth, R., Sarkar, S., Bose, D., Saha, P., Kimono, D., Albadrani, M., Nagarkatti, M., Nagarkatti, P. and Chatterjee, S., 2020. Lipocalin 2 Induces Neuroinflammation through Liver‐Brain Axis in Nonalcoholic Fatty Liver Disease. Experimental Biology-2020. The FASEB Journal, 34(S1), pp.1-1. 72. **Mondal, A., Seth, R., Bose, D., Nagarkatti, M., Nagarkatti, P. and Chatterjee, S., 2020. Butyrate Priming Improves Gut Health by Modulating Host Protease Activity in Murine Non‐Alcoholic Fatty Liver Disease. Experimental biology 2020. The FASEB Journal, 34(S1), pp.1-1. 73. **A. Mondal, D. Bose, P. Saha, R.Seth, M. Nagarkatti, P. Nagarkatti and S. Chatterjee. Environmental organophosphate co-exposure in pre-existing systemic inflammation can Increase susceptibility to SARS-COV-2 infection in human lung epithelial cells. Experimental Biology 2021, April 27-30, 2021. 74. **A. Mondal, D. Bose, P. Saha, R. Seth, GI Scott, S. Xiao, D Porter, B. Brooks and S. Chatterjee. Microcystin-LR exacerbates neuroinflammation and neurodegeneration in Nonalcoholic fatty liver disease. Experimental Biology 2021, April 27-30, 2021. 75. Bose D., Kimono D., Sarkar S., Albadrani M., Mondal A., Seth R, Sullivan K., Janulewicz P., Nagarkatti M., Nagarkatti P., Horner R., Klimas N., Chatterjee S. Sparstolonin B, a TLR4 antagonist is a prime candidate to restore systemic inflammation and gut health in GWI mouse models in a GWI model. VISN7 3rd Annual Research Symposium at Birmingham VA Medical Center, November 14, 2019. 76. **Bose D, Mondal A., Saha P., Seth R., Sullivan K., Janulewicz P., Horner R., Klimas N., Chatterjee S.Prolonged antibiotic use worsens neuroinflammation and increases the risk of neurodegeneration via elevated expression of systemic IL-6 in Gulf War Illness symptom persistence murine model. Experimental Biology 2021, April 27-30, 2021. Abstract R3563. 77. Bose D, Seth R, Mondal A, Saha P, Sullivan K, Janulewicz P, Klimas N, Horner R, Michelotti G, Chatterjee S. NLRP3 inflammasome knockdown ameliorates altered metabolic profile associated symptom persistance in murine model of Gulf War Illness. 2021 Military Health Research Symposium, August 23-26, 2021. Abstract MHSRS-21- 04554. (Submitted) 78. **P. Saha, P. T. Skidmore, L. A. Holland, A. Mondal, D. Bose, R. Seth, K. Sullivan, P. Janulewicz, R. Horner, N. Klimas, M. Nagarkatti, P. Nagarkatti, E. S. Lim, and S. Chatterjee. "Andrographolide Treatment Lessens Localized, Systemic Inflammation and Improves Other Pathophysiological Traits in a Mouse Model of Gulf War Illness" Experimental Biology, April 27-30, 2021 79. **Ratanesh K Seth , Punnag Saha , Dipro Bose , Ayan Mondal , Kimberly Sullivan , Patricia Janulewicz Lloyd Ronnie Horner , Nancy Klimas , Saurabh Chatterjee, Nexinhib 20 ameliorates hepatic extracellular HMGB1 mediated M1 polarization and liver inflammation in a mouse model of Gulf War Illness. Experimental Biology, April 27-30, 2021.
List of Presentations /seminars ⎯ Invited talks are highlighted in garnet-colored asterisk. ⎯ National and international acclaimed conferences/meetings where Dr. Chatterjee was invited as a leader in the field are underlined. 2012-2021
1. **Role of TRPV4 in environmental links to NAFLD, June 10, International conference of TRPV4 in health and Disease, Host American Physiological Society and Dr. Wolfgang Liedtke (Virtual), 2021 2. **Gulf War Illness: Linking Gut and Brain Health, May 19, 2021, Columbia VA Medical Center Research Seminar Series, VA Research Week 2021, Host Dr. Michael Ryan, ACOS-R VAMC ORD. 3. **Environmental exposures and Gut Brain Interactions, March 19, 2021, Department of Environmental Health, Indiana University School of Public Health. Host Dr. James Klaunig. 4. **Gut Microbiome in GWI, An unstable Resistome and Targeted Therapeutics. Invited presentation at the Curriculum Vitae: Saurabh Chatterjee, Ph.D. Research Advisory Committee on Gulf War Veterans’ Illnesses, March 10th, 2021 (Virtual) Host Dr. Lawrence Steinman, Stanford University and Dr. Karen Block, Department of Veterans Affairs. 5. **Microcystin priming and development of metabolic syndrome. Session on Human Populations and Influences in the Coastal Zone: Effects on Ocean and Human Health (OHH) III, American Geological Society annual meeting and international conference, Feb 19, 2020. San Diego CA 6. **Harmful Algal Blooms and chronic diseases: Role of Liver-Gut-Brain axis. Baylor University, Waco, Texas. Host: Professor Bryan Brooks, Baylor University, February 6th, 2020 7. **Early Life Exposure, Microcystin and Susceptibility to Hepatic Injury, Oceans and Human Health invited speaker at US HABS meeting, Pensacola Florida. November 8th, 2019. 8. ** "Algal blooms and Liver Disease" Panel speaker at the Joint Forum on Global Health organized by Nanjing Medical University, Nanjing, China, July 24th, 2019 9. ** "Cyanobacterial Toxins and the Liver-Gut-Brain Axis: Implications in Aging and Obesity," Plenary speaker at the Gordon Research Conference on Water, Urbanization and Food Security, July 21-26 2019, Hongkong University of Technology, Hongkong SAR. 10. **Gut Liver Axis in Liver Health, Invited speaker at the St Xaviers College, Department of Microbiology, University of Calcutta, India July 6th, 2019. Host Dr. Sudeshna Shyam Chowdhury. 11. ** "Drinking HABS and Gut-ting the liver". Session speaker at Oceans 2018, Charleston SC. Session Chair : Dr. Paul Sandifer 12. ** "Tolls take its toll in Gulf War Illness Pathology, Boston University School of Medicine, BUSPH, Boston, April 2018, Host Dr. Kim Sullivan 13. ** 'Microbiome in gut system health and probiotics for cure in Gulf War Veterans' illness. Dr. Saurabh Chatterjee, Military Health System Research Symposium, Orlando August 2017. Sponsored by Department of Defense 14. **Probiotic protection of Neurocognitive disturbances in Gulf War Chemical Exposures" GWVI Field Meeting at Palo Alto, CA. Organized by the Veterans Affairs Administration. 15. **Colonic Inflammation in Nonalcoholic Fatty Liver Disease: 2nd Southeast Cancer Immunology, Immunotherapy and Inflammation Research Retreat September 2017 (SCIIIR Retreat), Medical University of Georgia (Formerly Georgia Regents University). 16. **Clemson University, Environmental Toxicology Program, November, 2016. Host: Dr. Bill Baldwin, Professor 17. ** National Institutes of Health, Obesity Grantee meeting, September 21-22,2016 Bethesda MD. Host Dr. Jerry Heindel. 18. **TRPV4 and liver disease. Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, August 2016. Host: Dr. Stephen Lasley. 19. **Ion Channel proteins and chronic NAFLD. Department of Molecular Biology and Biophysics, University College of Science and Technology, University of Calcutta, June, 2016. Host: Professor (Dr.) Sharmistha Raychowdhury. 20. **Society of Toxicology, 2016, Advance CE Course speaker. Session AM002, New Orleans, LA. http://www.toxicology.org/pubs/docs/Prog/2016overview.pdf 21. **Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, October 14, 2014 Host: Dr. Rick Schnellmann, Chair. 22. **NIEHS/NIH sponsored Tamburro Environmental Liver Disease Symposium, University of Louisville, School of Medicine. September 9-11, 2014. Louisville, KY 23. Society of Toxicology 2014: Special symposium: "Does this chemical make my liver look fat". March 25 2014, University of Louisville. 24. Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Host : Dr. Mitzi Nagarkatti, October 2012 25. Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Host: Dr. James Carson, Chair. November 2012 26. **Department of Cell Biology and Pharmacology, College of Medicine, Florida International University, Miami FL, 2012. Host: Dr. George Petroianu, Chair. Curriculum Vitae: Saurabh Chatterjee, Ph.D.
Research Collaborations
1. Dr. Anna Mae Diehl, Division of Gastroenterology, Duke University School of Medicine, Durham, NC. 2. Dr. Maria Kadiiska, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NC 27709. 3. Dr. Mitzi Nagarkatti, Pathology, Immunology and Microbiology, USCMED. 4. Dr. Darwin Bell, University of Alabama at Birmingham 5. Dr. Wolfgang Liedtke, Duke University 6. Dr. Daping Fan, USC, SOM 7. Dr. Angela Murphy, USC, SOM 8. Dr. Konstantinos Makris, Harvard University 9. Dr. James Burch, Epidemiology and Biostatistics, USC. 10. Dr. Stephen Lasley, UIC Peoria 11. Dr. Ronnie Horner, USC Columbia 12. Dr. William Baldwin, Clemson University. 13. Dr. Kim Sullivan, Boston University 14. Dr. Patricia Janulewicz, Boston University 15. Dr. Nancy Klimas, Nova South Eastern University 16. Dr. Efrem Lim, Arizona State University
Professional Services:
Dates Duties/Details Recompense Manuscript reviews for journals listed below: 2012-present ⎯ Brain Behaviour and Immunity None ⎯ Toxicological Sciences ⎯ Drug Dis. Metab. ⎯ Experimental Biol. Med. ⎯ Free Radical Biology and Metabolism ⎯ Medical Principles and Practice ⎯ PloS ONE ⎯ Toxicology and Applied Pharmacology ⎯ Current Medicinal Chemistry ⎯ Chemical Research in Toxicology ⎯ Laboratory Investigation ⎯ World Journal of Gastroenterology ⎯ Hepatology ⎯ Journal of Clinical and Experimental ⎯ Gastroenterology ⎯ Nutrition Research ⎯ World Journal of Hepatology ⎯ BBA-Molecular Basis of Disease ⎯ BBA-Gene Regulatory Mechanisms ⎯ Scientific reports Curriculum Vitae: Saurabh Chatterjee, Ph.D. ⎯ British Journal of Pharmacology ⎯ Journal of Clinical investigation ⎯ Nature Communications ⎯ Life Sciences
Journal Editorial boards 2014-2017 ⎯ World Journal of Hepatology None 2019-Present ⎯ International Journal of Environmental Public Health 2020-Present ⎯ Frontiers in Immunology
Professional society memberships and service
2012-2015 ⎯ Full Member, American Association for the study of Liver None Diseases (AASLD) 2010- present ⎯ Full Member Society of Toxicology (SOT) 2008-present ⎯ Regular Member, American Association of Immunologists (AAI) 2007-present ⎯ Regular Member, American Physiological Society (APS) 2007-present ⎯ Full Member, Society for Free Radical Biology and Medicine(sFRBM)
Professional activities including federal responsibilities: 2012-2020
2017 ⎯ Veterans Affairs Strategic Planning Group member (Gulf War None Illness research) 2017-2018 ⎯ Society of Redox Biology and Medicine, Membership Committee ⎯ Society of Redox Biology and Medicine, Young Investigator 2017-2018 Awards Committee ⎯ Postdoctoral mentor SOT 2013-present ⎯ Postdoctoral/ Graduate student mentor: Society of Free 2012- present Radical Biology and Medicine (sFRBM) ⎯ Program committee member, Immunotoxicology Specialty 2015-2016 Section, SOT ⎯ Board of Directors, Association of Scientists of Indian Origin 2015-2016 Special Interest Group, SOT
Professional services at the University of South Carolina (U of SC)
2014-2017 ⎯ ENHS Representative for faculty senate None 2014-Present ⎯ Internal Grant review committee, Office of Vice President of Research (VPR) and School of Medicine (SOM) 2016-Present ⎯ Awards Committee, Office of VPR, 2017-2020 ⎯ Tenure Review Board
Professional services at the College (Arnold School of Public Health-ASPH) U of SC.
2012-2014 ⎯ Information Technology and resources committee None 2016-present ⎯ ASPH Tenure and Promotion committee 2016-present ⎯ MPH Core competencies Study Group 2017-2019 ⎯ ASPH new (2019) Tenure and Promotion guidelines 2019-present ⎯ ASPH Research Advisory committee Curriculum Vitae: Saurabh Chatterjee, Ph.D. Professional services at the Department (Environment Health Sciences- ENHS) U of SC.
2013-2014 ⎯ ENHS Chair search committee None 2013-2016 and 2019- ⎯ ENHS Admissions Committee present 2015-Present ⎯ ENHS Faculty Search Committee 2017-present ⎯ ENHS Ph.D. curriculum committee
Professional Activities (Grant Review Panels, Extramural/Intramural; 2013-present)
2019-present ⎯ NIH (NIDDK) R01 Special Emphasis panel ZRG1- EMNR-B (50)S Yes 2019- present ⎯ NIH (NIDDK) R01 Special Emphasis Panel ZRG1 EMNR A 51 2019- present ⎯ Austrian Science Foundation 2017-2019 ⎯ Ford Foundation, National Academy of Sciences, 2015 ⎯ Medical Research Council, United Kingdom 2015 ⎯ NIH K99/R00 (ZES1 JAB-J (KS) 2015 ⎯ SC Space Grant & SC NASA EPSCoR 2014 ⎯ NIH K99/R00 (ZES1 LWJ-K (K9) 2 2013-Present ⎯ Department of Science Education, Czech republic, Consortium of Science Development 2014 ⎯ University of South Carolina, Office of the vice president of Research, ASPIRE Track II review Panel. 2013-2014 ⎯ University of South Carolina, School of Medicine internal funding competition.
Professional Mentoring : Name Position Year Current position/Alumni Postdoctoral fellows (Major Advisor) Dr. Ratanesh Seth Postdoctoral fellow 2012-2017 Research Assistant Professor (University of South Carolina) Dr. Ayan Mondal Postdoctoral fellow 2019-2021 Postdoctoral fellow (Stanford University) Dr. Somdatta Chatterjee Research Associate 2021-Present - Graduate Students (Major Advisor) Dipro Bose Ph.D. (Student) 2019-Present - Punnag Saha Ph.D. (Student) 2019-Present - Macayla Upright M.S. (Student) 2020-Present - Dr. Diana Kimono Ph.D. (Completed) 2016-2020 Postdoc, NYU Langone Medical Center. Dr. Sutapa Sarkar Ph.D. (Completed) 2016-2019 Postdoc, Stanford University School of Medicine Dr. Muayad Albadrani Ph.D. (Completed) 2016-2019 Assistant Professor at Taibah University, Saudi Arabia. Dr. Firas Alhasson Ph.D. (Completed) 2014-2018 Postdoc, University of Calgary, Canada Dr. Varun Ph.D. (Completed) 2014-2017 Postdoc, Weill Cornell Medical College, NY Chandrashekaran Dr. Diptadit DattaRoy Ph.D. (Completed) 2014-2017 Postdoc, NIDDK/NIH Bethesda Dr. Suvarthi Das Ph.D. (Completed) 2012-2016 Postdoc, Stanford University School of Medicine Curriculum Vitae: Saurabh Chatterjee, Ph.D.
Ph.D. Students (Committee Member) Dr. Brandon Busbee Ph.D. (Completed) UofSC School of Medicine Dr. David Elliot Ph.D. (Completed) UofSC School of Medicine Dr. Pallavi Balte Ph.D. (Completed) UofSC School of Public Health Dr. Sunil Tomar Ph.D. (Completed) UofSC School of Medicine Dr. Mellisa Heintz Ph.D. (Completed) Clemson University Dr. Woorod Neamah Ph.D. (Completed) UofSC School of Medicine Dr. Faatma Saud Ph.D. (Completed) UofSC School of Medicine Yingzheng Wang Continuing UofSC School of Public Health Alkeiver Cannon continuing UofSC School of Medicine Hannah Burzynski Continuing UofSC School of Medicine Bryan Holloman Continuing UofSC School of Medicine