University of Vermont ScholarWorks @ UVM Graduate College Dissertations and Theses Dissertations and Theses 2016 Homology Modeling and Molecular Docking of Antagonists to Class B G-Protein Coupled Receptor Pituitary Adenylate Cyclase Type 1 (PAC1R) Suzanne Louise Stanton University of Vermont Follow this and additional works at: https://scholarworks.uvm.edu/graddis Part of the Chemistry Commons Recommended Citation Stanton, Suzanne Louise, "Homology Modeling and Molecular Docking of Antagonists to Class B G-Protein Coupled Receptor Pituitary Adenylate Cyclase Type 1 (PAC1R)" (2016). Graduate College Dissertations and Theses. 624. https://scholarworks.uvm.edu/graddis/624 This Thesis is brought to you for free and open access by the Dissertations and Theses at ScholarWorks @ UVM. It has been accepted for inclusion in Graduate College Dissertations and Theses by an authorized administrator of ScholarWorks @ UVM. For more information, please contact
[email protected]. HOMOLOGY MODELING AND MOLECULAR DOCKING OF ANTAGONISTS TO CLASS B G-PROTEIN COUPLED RECEPTOR PITUITARY ADENYLATE CYLCASE TYPE 1 (PAC1R) A Thesis Presented by Suzanne Louise Stanton to The Faculty of the Graduate College of The University of Vermont In Partial Fulfillment of the Requirements for the Degree of Master of Science Specializing in Organic Chemistry/Chemistry October, 2016 Defense Date: May 9, 2016 Thesis Examination Committee: Matthias Brewer, Ph.D., Advisor Jose Madalengoitia, Ph.D. Victor May, Ph.D. Rory Waterman, Ph.D. Cynthia J. Forehand, PhD., Dean of the Graduate College ABSTRACT Recent studies have identified the Class B g-protein coupled receptor (GPCR) pituitary adenylate cyclase activating polypeptide type 1 (PAC1R) as a key component in physiological stress management.