A Systematic Umbrella Review and Meta-Analysis of Alzheimer's
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Health Economics & Decision Science
School of Health And Related Research Health Economics & Decision Science (HEDS) Discussion Paper Series Factors influencing the use of research for policy-making: an umbrella review protocol Authors: Erika E. Atienzo, Eva Kaltenthaler, Susan K. Baxter Corresponding author: Erika E. Atienzo ScHARR, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA Fax: (+44) (0)114 222 0749 Email: [email protected] No. 16.07 Disclaimer: This series is intended to promote discussion and to provide information about work in progress. The views expressed in this series are those of the authors. Comments are welcome, and should be sent to the corresponding author. This paper is also hosted on the White Rose Repository: http://eprints.whiterose.ac.uk/ FACTORS INFLUENCING THE USE OF RESEARCH FOR POLICY-MAKING: AN UMBRELLA REVIEW PROTOCOL Erika E. Atienzoa*, Eva Kaltenthalera, Susan K. Baxterb a Health Economics and Decision Science, School of Health and Related Research, University of Sheffield b Public Health, School of Health and Related Research, University of Sheffield *Corresponding author: Erika E. Atienzo ScHARR, University of Sheffield Regent Court, 30 Regent Street Sheffield, S1 4DA (UK) [email protected] March 2016 ABSTRACT Over the last two decades, there has been an emphasis on the concept of evidence-based policy. However, evidence-based policy remains a major challenge and a gap exists in the systematic translation of scientific knowledge into policies. The awareness of this evidence- policy gap has led to a proliferation of research. As the demand for evidence-informed policy-making escalates, so does the need to unveil the mechanisms by which we can influence the process of research uptake. -
Are Nsaids Useful to Treat Alzheimer's Disease Or Mild Cognitive
REVIEW ARTICLE published: 21 May 2010 AGING NEUROSCIENCE doi: 10.3389/fnagi.2010.00019 Are NSAIDs useful to treat Alzheimer’s disease or mild cognitive impairment? Bruno P. Imbimbo1*, Vincenzo Solfrizzi 2 and Francesco Panza 3 1 Research and Development Department, Chiesi Farmaceutici, Parma, Italy 2 Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy 3 Department of Medical Sciences, Geriatric Unit and Gerontology-Geriatrics Research Laboratory, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Foggia, Italy Edited by: Several epidemiological studies suggest that long-term use of non-steroidal anti-infl ammatory Elena Galea, Universitat Autònoma de drugs (NSAIDs) may protect subjects carrying one or more ε4 allele of the apolipoprotein E Barcelona, Spain (APOE ε4) against the onset of Alzheimer’s disease (AD). The biological mechanism of this Reviewed by: Mathieu Lichtenstein, Universitat protection is not completely understood and may involve the anti-infl ammatory properties of Autònoma de Barcelona, Spain NSAIDs or their ability of interfering with the β-amyloid (Aβ) cascade. Unfortunately, long-term, Merce Boada, Institut Català de placebo-controlled clinical trials with both non-selective and cyclooxygenase-2 (COX-2) selective Neurociències Aplicades, Spain inhibitors in mild-to-moderate AD patients produced negative results. A secondary prevention Elena Galea, Universitat Autònoma de Barcelona, Spain study with rofecoxib, a COX-2 selective inhibitor, in patients with mild cognitive impairment *Correspondence: was also negative. A primary prevention study (ADAPT trial) of naproxen (a non-selective COX Bruno P. Imbimbo, Research and inhibitor) and celecoxib (a COX-2 selective inhibitor) in cognitively normal elderly subjects with Development Department, Chiesi a family history of AD was prematurely interrupted for safety reasons after a median period Farmaceutici, Via Palermo 26/A, 43100 of treatment of 2 years. -
(12) Patent Application Publication (10) Pub. No.: US 2012/0202780 A1 Gavin Et Al
US 20120202780A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0202780 A1 Gavin et al. (43) Pub. Date: Aug. 9, 2012 (54) CARRIER COMPOSITION Publication Classification (76) Inventors: Paul David Gavin, Chadstone (51) Int. Cl. (AU); Mahmoud El-Tamimy, A6II 47/24 (2006.01) Meadow Heights (AU); Jeremy A6II 3/196 (2006.01) James Cottrell, Caulfield South A6IP5/00 (2006.01) (AU); Giacinto Gaetano, South A 6LX 3/573 (2006.01) Melbourne (AU); Nicholas John A6IP 23/00 (2006.01) Kennedy, Boronia (AU) A6IP 29/00 (2006.01) A6II 3/167 (2006.01) (21) Appl. No.: 13/501,494 A63L/407 (2006.01) (22) PCT Fled: Dec. 22, 2010 (52) U.S. Cl. ......... 514/180: 514/785: 514/788: 514/772: 514/626; 514/567; 514/413: 514/179 (86) PCT NO.: S371 (c)(1), (57) ABSTRACT (2), (4) Date: Apr. 12, 2012 A carrier composition of the present invention comprises a phosphate compound of an electron transfer agent and a rela Related U.S. Application Data tively high concentration of a polar protic solvent. A biologi (60) Provisional application No. 61/289,507, filed on Dec. cally active compound may be formulated with a carrier com 23, 2009. position of the present invention to provide a formulation. Patent Application Publication Aug. 9, 2012 Sheet 1 of 5 US 2012/0202780 A1 - - if solvent E. -ie-20% solvent 3. ". S. .t E FGURE 1 Patent Application Publication Aug. 9, 2012 Sheet 2 of 5 US 2012/0202780 A1 -H 10 LC2 s -C- 20 ulcm2 . - a 30 ulcm2 t E re FIGURE 2A HO licm2 80i -o- 20 ul/cm2 'i -A-30 ul/cm2 140 EO 10 8 8 4) O O FIGURE 2B Patent Application Publication Aug. -
A Meta-Review of Transparency and Reproducibility-Related Reporting Practices in Published Meta- Analyses on Clinical Psychological Interventions (2000-2020)
A meta-review of transparency and reproducibility-related reporting practices in published meta- analyses on clinical psychological interventions (2000-2020). Rubén López-Nicolás1, José Antonio López-López1, María Rubio-Aparicio2 & Julio Sánchez- Meca1 1 Universidad de Murcia (Spain) 2 Universidad de Alicante (Spain) Author note: This paper has been published at Behavior Research Methods. The published version is available at: https://doi.org/10.3758/s13428-021-01644-z. All materials, data, and analysis script coded have been made publicly available on the Open Science Framework: https://osf.io/xg97b/. Correspondence should be addressed to Rubén López-Nicolás, Facultad de Psicología, Campus de Espinardo, Universidad de Murcia, edificio nº 31, 30100 Murcia, España. E-mail: [email protected] 1 Abstract Meta-analysis is a powerful and important tool to synthesize the literature about a research topic. Like other kinds of research, meta-analyses must be reproducible to be compliant with the principles of the scientific method. Furthermore, reproducible meta-analyses can be easily updated with new data and reanalysed applying new and more refined analysis techniques. We attempted to empirically assess the prevalence of transparency and reproducibility-related reporting practices in published meta-analyses from clinical psychology by examining a random sample of 100 meta-analyses. Our purpose was to identify the key points that could be improved with the aim to provide some recommendations to carry out reproducible meta-analyses. We conducted a meta-review of meta-analyses of psychological interventions published between 2000 and 2020. We searched PubMed, PsycInfo and Web of Science databases. A structured coding form to assess transparency indicators was created based on previous studies and existing meta-analysis guidelines. -
Review on Evaluating the Role of Nsaids for the Treatment of Alzheimer's Disease
International Journal of Applied Pharmaceutics ISSN- 0975-7058 Vol 13, Issue 1, 2021 Review Article REVIEW ON EVALUATING THE ROLE OF NSAIDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE KRISHNENDU P. R.a, ARJUN B.a, VIBINA K.b, NIVEA CLEO T. S.c, DRISYA N. K.c, RADHIKA MOHANDASb, SUBIN MARY ZACHARIAHd* a,dDepartment of Pharmaceutical Chemistry and Analysis, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, AIMS, Kochi 682041, Kerala, India, bDepartment of Pharmaceutical Chemistry, Lecturer, Crescent College of Pharmaceutical Science, Madayipara, P O. Payangadi (R. S.), 670358, Kannur, Kerala, India, cDepartment of Pharmaceutical Chemistry, Lecturer, KMCT College of Pharmaceutical Sciences, Technical Campus, Kallanthode, NITC, Calicut,673601, Kerala, India *Email: [email protected] Received: 05 Oct 2020, Revised and Accepted: 27 Nov 2020 ABSTRACT Recently, several studies have been reported that nonsteroidal anti-inflammatory drugs can fight against neurodegenerative disorders by various mechanisms. Currently, available therapies of neurodegenerative disorders (NDs) provide only symptomatic relief. This is the point at which we need an alternative that acts on the root cause of disease. Parkinson’s disease and Alzheimer’s disease are the two NDs concentrated here. Since the drug profile is already known, drug repurposing is a promising technique in research, thereby reducing the cost and period effectively. Epidemiological studies on various nonsteroidal anti-inflammatory drugs (NSAIDs) showed good results, but when it came to clinical studies the results are found to be poor. Hence, it can be concluded that NSAIDs provide its neuroprotective activity on its long-term use only, as the brain accessibility of this kind of drug is poor due to its lower lipophilicity. -
Phenotype-Based Drug Screening Reveals Association Between Venetoclax Response and Differentiation Stage in Acute Myeloid Leukemia
Acute Myeloid Leukemia SUPPLEMENTARY APPENDIX Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia Heikki Kuusanmäki, 1,2 Aino-Maija Leppä, 1 Petri Pölönen, 3 Mika Kontro, 2 Olli Dufva, 2 Debashish Deb, 1 Bhagwan Yadav, 2 Oscar Brück, 2 Ashwini Kumar, 1 Hele Everaus, 4 Bjørn T. Gjertsen, 5 Merja Heinäniemi, 3 Kimmo Porkka, 2 Satu Mustjoki 2,6 and Caroline A. Heckman 1 1Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki; 2Hematology Research Unit, Helsinki University Hospital Comprehensive Cancer Center, Helsinki; 3Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland; 4Department of Hematology and Oncology, University of Tartu, Tartu, Estonia; 5Centre for Cancer Biomarkers, De - partment of Clinical Science, University of Bergen, Bergen, Norway and 6Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland ©2020 Ferrata Storti Foundation. This is an open-access paper. doi:10.3324/haematol. 2018.214882 Received: December 17, 2018. Accepted: July 8, 2019. Pre-published: July 11, 2019. Correspondence: CAROLINE A. HECKMAN - [email protected] HEIKKI KUUSANMÄKI - [email protected] Supplemental Material Phenotype-based drug screening reveals an association between venetoclax response and differentiation stage in acute myeloid leukemia Authors: Heikki Kuusanmäki1, 2, Aino-Maija -
Therapeutic Benefits of Glutamine: an Umbrella Review of Meta-Analyses
576 BIOMEDICAL REPORTS 6: 576-584, 2017 Therapeutic benefits of glutamine: An umbrella review of meta-analyses MARC P. McRAE Department of Basic Science, National University of Health Sciences, Lombard, IL 60148, USA Received February 8, 2017; Accepted March 9, 2017 DOI: 10.3892/br.2017.885 Abstract. Glutamine may be an essential amino acid in and shortening of the length of stay in hospital. Furthermore, patients with catabolic disease, as it has been demonstrated glutamine supplementation appeared to reduce the rate of that circulating glutamine levels drop during critical illness in-patient mortality, but the majority of meta-analyses did and following major surgery; this may result in an increase in not reach statistical significance. However, researchers must secondary infection risk, recovery time and mortality rates. appreciate the positive results with caution in light of the However, there is much discrepancy in the literature with fact that there exists statistically significant heterogeneity for regards to randomized controlled studies, and therefore, the the majority of meta-analyses, and statistically significant present study is an umbrella review of published meta-analyses, publication bias in almost half. conducted to examine the effectiveness of glutamine's role as a therapeutic agent. A search using PubMed, Cochrane Library Introduction and CINAHL from January 1st, 1980 to December 31st, 2016 was conducted using the following strategy: ‘Glutamine AND Glutamine may be a conditionally essential amino acid in (meta-analysis OR systematic review)’ and publications were patients with catabolic disease as it has been demonstrated retrieved, which provided quantitative statistical analysis of that circulating plasma glutamine concentrations drop during pooled treatment effects on the relative risks of infectious critical illness and following major surgery (1). -
Ozone Exposure and Health Effects: a Protocol for an Umbrella Review and Effect-Specific Systematic Maps
Open access Protocol BMJ Open: first published as 10.1136/bmjopen-2019-034854 on 13 August 2020. Downloaded from Ozone exposure and health effects: a protocol for an umbrella review and effect-specificsystematicmaps Tianyu Zhao ,1,2,3,4 Iana Markevych,1,2,3,5 Christian Janßen,4 Dennis Nowak,1,2 Nadine Steckling- Muschack,1,6 Joachim Heinrich1,2,3,7 To cite: Zhao T, Markevych I, ABSTRACT Strengths and limitations of this study Janßen C, et al. Ozone Introduction Ambient ozone exposure may be adverse exposure and health effects: to health. Since the reported associations between ozone ► To the best of our knowledge, this protocol is the a protocol for an umbrella and health effects are heterogeneous and the underlying review and effect- specific first one for an umbrella review or a systematic map pathways are indistinct, the overall relationship remains systematic maps. BMJ Open focusing on ozone exposure and health outcomes. unclear. Only a few overall syntheses of the evidence 2020;10:e034854. doi:10.1136/ ► The umbrella review will provide a comprehensive regarding ozone and health effects are available to date. bmjopen-2019-034854 outline of the currently available systematic reviews Methods and analysis We plan to summarise the current on ambient ozone exposure and health outcomes, ► Prepublication history and evidence on ozone- related health effects systematically. and an epidemiological evidence reservoir accessi- additional material for this First, to identify the possible associations between paper are available online. To ble to the public. ambient ozone exposure and health outcomes, we will view these files, please visit ► The systematic map of a specific ozone-rela ted conduct an umbrella review. -
Wo 2011/060944 A2
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date _ . ... _ 26 May 2011 (26.05.2011) WO 2011/060944 A2 (51) International Patent Classification: (74) Agents: CARVAJAL Y URQUIJO, Isabel et al; A61K 9/16 (2006.01) A61K 9/50 (2006.01) Clarke, Modet & Co., C/Goya 11, 28001 Madrid (ES). A61K 9/48 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/EP20 10/007024 AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (22) International Filing Date: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 19 November 2010 (19.1 1.2010) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (25) Filing Language: English KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (26) Publication Langi English NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (30) Priority Data: SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 200931026 20 November 2009 (20.1 1.2009) ES TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicants (for all designated States except US): GP (84) Designated States (unless otherwise indicated, for every PHARM, S.A. [ES/ES]; Poligono Industrial Els Vinyets- kind of regional protection available): ARIPO (BW, GH, Els Fogars, Ctra. -
Identifying Approaches for Assessing Methodological and Reporting
Pussegoda et al. Systematic Reviews (2017) 6:117 DOI 10.1186/s13643-017-0507-6 RESEARCH Open Access Identifying approaches for assessing methodological and reporting quality of systematic reviews: a descriptive study Kusala Pussegoda1, Lucy Turner1, Chantelle Garritty1,2, Alain Mayhew1, Becky Skidmore1, Adrienne Stevens1,2, Isabelle Boutron3, Rafael Sarkis-Onofre4, Lise M. Bjerre5,6,7, Asbjørn Hróbjartsson8, Douglas G. Altman9 and David Moher10* Abstract Background: The methodological quality and completeness of reporting of the systematic reviews (SRs) is fundamental to optimal implementation of evidence-based health care and the reduction of research waste. Methods exist to appraise SRs yet little is known about how they are used in SRs or where there are potential gaps in research best-practice guidance materials. The aims of this study are to identify reports assessing the methodological quality (MQ) and/or reporting quality (RQ) of a cohort of SRs and to assess their number, general characteristics, and approaches to ‘quality’ assessment over time. Methods: The Cochrane Library, MEDLINE®, and EMBASE® were searched from January 1990 to October 16, 2014, for reports assessing MQ and/or RQ of SRs. Title, abstract, and full-text screening of all reports were conducted independently by two reviewers. Reports assessing the MQ and/or RQ of a cohort of ten or more SRs of interventions were included. All results are reported as frequencies and percentages of reports. Results: Of 20,765 unique records retrieved, 1189 of them were reviewed for full-text review, of which 76 reports were included. Eight previously published approaches to assessing MQ or reporting guidelines used as proxy to assess RQ were used in 80% (61/76) of identified reports. -
Summarizing Systematic Reviews: Methodological Development
METHODOLOGY PAPER Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach Edoardo Aromataris,1 Ritin Fernandez,2 Christina M. Godfrey,3 Cheryl Holly,4 Hanan Khalil5 and Patraporn Tungpunkom6 1The Joanna Briggs Institute, University of Adelaide, Adelaide, South Australia, 2School of Nursing, University of Wollongong; Centre for Research in 05/21/2018 on BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD3gy8G8VagVy1noQVV3wH2du7UHDCprP5m8mBdFQ69S0Y= by https://journals.lww.com/ijebh from Downloaded 3 Downloaded Nursing and Health, St George Hospital, Sydney, Australia, Queen’s Joanna Briggs Collaboration, Queen’s University School of Nursing, Kingston, Ontario, Canada, 4Northeast Institute for Evidence Synthesis and Translation Rutgers, University School of Nursing Newark, New Jersey, USA, 5 6 from Monash University, School of Rural Health, Victoria, Australia, and Thailand Centre for Evidence Based Nursing, Midwifery, and Health Science: https://journals.lww.com/ijebh a Collaborating Centre of JBI, Faculty of Nursing, Chiang Mai University, Chiang Mai, Thailand ABSTRACT by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD3gy8G8VagVy1noQVV3wH2du7UHDCprP5m8mBdFQ69S0Y= Aims: With the increase in the number of systematic reviews available, a logical next step to provide decision makers in healthcare with the evidence they require has been the conduct of reviews of existing systematic reviews. Syntheses of existing systematic reviews are referred to by many different -
An Umbrella Review and Narrative Synthesis of the Effectiveness Of
International Journal of Environmental Research and Public Health Review An Umbrella Review and Narrative Synthesis of the Effectiveness of Interventions Aimed at Decreasing Food Prices to Increase Food Quality Chiara Milani 1, Chiara Lorini 2,* , Alberto Baldasseroni 3, Claudia Dellisanti 3 and Guglielmo Bonaccorsi 2 1 School of Specialization in Hygiene and Preventive Medicine, University of Florence, 50134 Florence, Italy 2 Department of Health Sciences, University of Florence, 50134 Florence, Italy 3 Department of Prevention, Local Health Unit Toscana Centro, 50135 Florence, Italy * Correspondence: chiara.lorini@unifi.it; Tel.: +39-0552751065 Received: 12 June 2019; Accepted: 1 July 2019; Published: 2 July 2019 Abstract: Background: sustainability of population diet is a public health concern: the high price of healthy food is one of the main causes of diet-related health problems. The aim of this study is to synthesize the evidence produced by systematic reviews that evaluated the effectiveness of decreasing healthy food prices to improve accessibility in order to positively modify the dietary pattern. Methods: We carried out a review of systematic reviews that examined the effects of the interventions, by exploring the online databases PubMed, Embase, Web of Science, Cochrane Library and hand-searching the reference lists. Results: after screening by titles and abstracts, we selected 11 systematic reviews that met the inclusion criteria, plus one that was hand-searched. The review generally presented a good quality. Studies concluded that measures aimed at modifying the prices of targeted healthy food were effective in improving population diet by modifying what people buy. Conclusions: the complexity of the outcome—population diet—as well as the poor transferability of data across populations and geographical areas makes it obligatory to provide clear and universal conclusions.