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Rheumatic Diswes This report contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the World Health Organization WHO Technical Report Series 816 RHEUMATIC DISWES Report of a WHO Scientific Groyp World Health Organization Geneva 1992 WHO Library Cataloguing in Publication Data WHO Scientific Group on Rheumatic Diseases Rheumatic diseases : report of a WHO scientific group. (WHO technical report series ; 816) 1. Rheumatic diseases I. Title 11. Series ISBN 92 4120816 3 (NLM Classification: WE 544) ISSN 0512-3054 © World Health Organization 1992 Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. For rights of reproduction or translation of WHO publications, in part or in toto, application should be made to the Office of Publications, World Health Organization, Geneva, Switzerland. The World Health Organi­ zation welcomes such applications. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. Printed in Switzerland 91/8919- Bentel1- 7500 Contents 1. Introduction 2. International cooperation in rheumatology 1 2.1 International League Against Rheumatism 1 2.1.1 Education and publications 2 2.1.2 Epidemiology 2 2.1.3 Clinical studies 3 2.1.4 National and international agencies 3 2.2 Recommendations for international cooperation 3 3. Educational programmes and opportunities for rheumatic diseases 3 3.1 Introduction 3 3.2 Public education 4 3.3 Undergraduate medical education 4 3.4 Postgraduate specialist education 5 3.5 Recommendations for training and research 6 4. Socioeconomic factors in rheumatic diseases 6 4.1 Introduction 6 4.2 International cooperation 8 4.3 Recommendations for research 8 5. Genetic factors in rheumatic diseases 9 5.1 Introduction 9 5.2 Recommendations for training and research 9 6. Rheumatoid arthritis 10 6.1 Introduction 10 6.1.1 Epidemiology 10 6.1.2 Clinical diagnosis 10 6.1.3 Pathogenesis 11 6.1.4 Rheumatoid factors and autoantibodies 11 6.2 Education 11 6.3 Cellular immunology 12 6.4 Lymphocyte trafficking and adherence 12 6.5 Regulation of the immune response 12 6.6 Recommendations for research 13 7. Systemic lupus erythematosus 14 7.1 Introduction 14 7.1.1 Clinical features 14 7.1.2 Diagnosis 14 7.1.3 Etiopathogenesis 15 7.1.4 Treatment 15 7.2 Education 16 7.3 Recommendations for research 16 8. Systemic sclerosis 17 8.1 Introduction 17 8.2 Pathophysiology 17 8.3 Treatment 19 iii 84 Prognosis and disease monitoring 19 8.5 Recommendations for research 20 8.5.1 Epidemiology 20 8.5.2 Immunology 20 8.5.3 Pathophysiology 21 8.54 Experimental therapeutics 21 9. Sjtigren syndrome 21 9.1 Introduction 21 9.2 Clinical spectrum 22 9.2.1 Diagnosis 22 9.2.2 Pathology 23 9.3 Education 24 94 Recommendations for research 24 9.4.1 Epidemiology 24 9.4.2 Immunopathology 24 94.3 Treatment 25 1 o. Lyme disease 25 10.1 Introduction 25 10.1.1 American history 25 10.1.2 European history 26 10.2 Clinical features 26 10.3 Diagnosis 27 104 Treatment 27 10.5 Education 28 10.6 Recommendations for research 28 1 0.6.1 Epidemiology 28 1 0.6.2 Clinical disease 29 1 0.6.3 Pathology 29 10.64 Prevention and treatment 29 11. Spondyloarthropathies 30 11.1 Introduction 30 11.2 Ankylosing spondylitis 31 11.3 Reiter syndrome 33 114 Psoriatic arthropathy 34 11.5 Education 34 11.6 Recommendations for research 35 12. Low back pain 36 12.1 Introduction 36 12.2 Treatment 37 12.3 Prevention 38 124 Recommendations for training and research 39 124.1 Etiology 39 124.2 Treatment 40 12.4.3 Long-term disability 40 13. Osteoarthritis 40 13.1 Introduction 40 13.1.1 Definition 41 13.1.2 Etiology 41 13.1.3 Pathology 42 iv 13.1 A Radiology 43 13.1.5 Clinical features 43 13.1.6 Treatment and outcome 44 13.2 Epidemiology 44 13.2.1 Prevalence 44 13.2.2 Risk-factors 45 13.2.3 The disease process 46 13.2.4 Impact and outcome 46 13.3 Education 46 13.4 Principal areas for research 48 13.4.1 Epidemiology 48 13.4.2 Clinical subsets 48 13.4.3 The role of trauma 48 13.4.4 The role of aging 49 13.4.5 The role of inflammation 49 13.4.6 The role of extracartilaginous structures 49 13.4.7 The role of the neuromuscular system 50 13.5 Recommendations for research 50 14. Soft-tissue rheumatism 52 14.1 Introduction 52 14.1.1 Fibromyalgia 52 14.1.2 Tendinitis, tenosynovitis, and bursitis 52 14.1.3 Polymyalgia rheumatica 53 14.1.4 Shoulder-hand syndrome 53 14.2 Education 54 14.3 Recommendations for research 54 14.3.1 General recommendations 54 14.3.2 Fibromyalgia 54 14.3.3 Tendinitis, tenosynovitis, and bursitis 55 14.3.4 Polymyalgia rheumatica 55 14.3.5 Shoulder-hand syndrome 55 15. Gout 55 15.1 Introduction 55 15.1.1 Hyperuricaemia 55 15.1.2 Crystal-induced inflammation 56 15.1.3 Population studies 56 15.1.4 Sustained hyperuricaemia 56 15.1.5 Juvenile familial gout 57 15.2 Treatment 57 15.3 Recommendations for research 58 Acknowledgements 59 V WHO Scientific Group on Rheumatic Diseases Geneva, 26-30 June 1989 Members• Professor E. Allander, Department of Social Medicine, Huddinge University Hospital, Huddinge, Sweden Professor L.l. Benevolenskaja, Institute of Rheumatology, Academy of Medical Sciences, Moscow, USSR Professor J.C. Bennett, Chairman, Department of Medicine, University of Alabama, Birmingham, AL. USA Professor K.D. Brandt, Head, Rheumatology Division, Indiana University School of Medicine, lndianapolis, IN, USA (Go-Rapporteur) Professor W.H. Chahade, Director, Rheumatology Service, Sao Paulo State Public Hospital, Sao Paulo, Brazil Professor Chang Nai-Cheng, Director of Rheumatology, Peking Union Medical College Hospital, Beijing, China Professor P. Dieppe, Professor of Rheumatology, Department of Medicine, University of Bristol, Bristol, England Professor L. Gordis, Chairman, Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD, USA Professor M. Homma, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan Professor A. N. Malaviya, Head, Clinical Immunology Service, Department of Medicine, All-lndia Institute of Medical Sciences, New Dehli, India Professor C.J. Menkes, Department of Rheumatology, Cochin Hospital, Paris, France Professor H. M. Moutsopoulos, Chairman, Department of Internal Medicine, University of loannina, loannina, Greece Or K.D. Muirden, Head, Rheumatology Unit, Department of Medicine, University of Melbourne, Victoria, Australia Professor A.L. Nachemson, Chief, Department of Orthopaedics, Gothenburg University, Gothenburg, Sweden Professor V.A. Nassonova, Director, Institute of Rheumatology, Academy of Medical Sciences of the USSR, Moscow, USSR Professor C. M. Plotz, Department of Medicine, State University of New York, Downstate Medical Center, New York, NY, USA Or J.T. Scott, Consultant Physician, Department of Rheumatology, Charing Cross Hospital, London, England (Go-Rapporteur) Or L.E. Shulman, Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA (Chairman) Professor J. Villiaumey, President, International League Against Rheumatism, Henri Mondor Hospital, Creteil, France (Vice-Chairman) * Unable to attend: Professor E. Munthe, Medical Director, Oslo City Department of Rheumatology, Oslo, Norway, and Professor H.A. Valkenburg, Department of Epidemiology, Erasmus University, Rotterdam, Netherlands. vi Secretariat Or E. Chigan, Director, Division of Noncommunicable Diseases, WHO, Geneva, Switzerland Or Hu Ching-Li, Assistant Director-General, WHO, Geneva, Switzerland Dr N.G. Khaltaev, Medical Officer, Diabetes and other Noncommunicable Diseases, WHO, Geneva, Switzerland (Secretary) vii 1. Introduction A WHO Scientific Group on Rheumatic Diseases met in Geneva from 26 to 30 June 1989. The meeting was opened by Dr Hu Ching-Li, Assistant Director-General, who welcomed participants on behalf of the Director­ General. The rheumatic diseases are a major cause of disability throughout the world. Chronic rheumatic conditions place a considerable social and economic burden on all societies, and not only on those with a high life expectancy. For example, the high prevalence of rheumatic complaints and disability in Indonesia, in both urban and rural areas, is similar to that in a more developed country such as Australia. Much research is taking place into the causes and treatment of rheumatic disease. Significant advances that will result in more effective prophylaxis and treatment have been made in the areas of genetics, immunology, pharmacology and connective tissue biochemistry. In other areas, however, such as epidemiology, rehabilitation, risk-factor identification, education, and the social consequences of rheumatic diseases, there is an urgent need for more research. This need is all the greater owing to the changing morbidity and mortality patterns in both developed and developing countries as a result of increasing life expectancy, the rapid growth of urban populations, changes in lifestyle, and other factors. In order to meet these new challenges effective rheumatological community control programmes are needed. These would encompass the education of professional staff and patients, community participation, early disease detection, and effective treatment and rehabilitation, and should be integrated into the existing primary health care system.
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