US007691419B2

(12) United States Patent (10) Patent No.: US 7.691,419 B2 DiLeva (45) Date of Patent: Apr. 6, 2010

(54) COMPOSITIONS AND METHODS FOR 6,440,437 B1 8/2002 Krzysik et al. TREATING SKIN CONDITIONS IN 6,495,148 B1 12/2002 Abbiati MAMMALS 6,576,269 B1 6/2003 Korneyev 6,579,543 B1 6/2003 McClung (76) Inventor: Rose Marie DiLeva, 20 Park La., Glenn 7,226,627 B1 * 6/2007 Eckert et al...... 424,766 2003/0091618 A1* 5, 2003. Seth et al...... 424/443 Mills, PA (US) 19342 2004/0234628 A1* 11/2004 Kearns et al...... 424,736 ck ... 424,669 (*) Notice: Subject to any disclaimer, the term of this 38.2 A. ck S. oliveira - - - - ... 604/292 patent is extended or adjusted under 35 2006/0172022 A1* 8, 2006 SZanzer ... 424/757 U.S.C. 154(b) by 0 days. 2007, 0166241 A1* 7, 2007 Baker ...... 424/47 2007/02071 15 A1* 9/2007 Liegeois ...... 424/74 (21) Appl. No.: 11/961,333 FOREIGN PATENT DOCUMENTS (22) Filed: Dec. 20, 2007 CN 1433,753 A * 8, 2003 (65) Prior Publication Data KR 2006092333 A * 8, 2005 US 2009/O1623O4 A1 Jun. 25, 2009 * cited by examiner (51) Int. Cl Primary Examiner Michele Flood Asik 3661 (2006.01) Assistant Examiner Qiuwen Mi A6 IK 36/886 (200 6,015 (74) Attorney, Agent, or Firm Fox Rothschild LLP; Gerard A6 IK 36/53 (2006.01) P. Norton; Roman Fayerberg A6 IK 36/00 (2006.01) A6 IK 36/87 (2006.01) (57) ABSTRACT A 6LX 3L/355 (2006.01) A topical composition for treating skin diseases is provided (52) U.S. Cl...... 'Tis7:E.A. The composition comprises calendula, tea tree oil, eucalyp s s tus oil, grape seed oil, and Aloe vera. In some embodiment, (58) Field of Classification Search ...... None the composition may also include beeswax, vegetable oil. See application file for complete search history. Vitamin E. rosemary oil, or shea butter or combinations (56) References Cited thereof to further enhance its beneficial effects. In some embodiments, the composition may also include herbs. Kits U.S. PATENT DOCUMENTS and methods for treatment of skin diseases are also disclosed. 4,784.842 A * 1 1/1988 London et al...... 424/45 6,063,406 A * 5/2000 Hornack ...... 424,678 4 Claims, No Drawings US 7.691,419 B2 1. 2 COMPOSITIONS AND METHODS FOR actions that include increasing blood flow to the affected area TREATING SKIN CONDITIONS IN and promoting the production of collagen proteins. Calen MAMMALS dula also possesses antiseptic and anti-inflammatory effects due to its flavonoid content. It has been widely used on the FIELD OF THE INVENTION skin to treat minor wounds, skin infections and inflamma tions, burns, bee stings, Sunburn, warts, and cancer, Surgical This invention relates to a composition for treatment of incisions, skin irritations, chapped lips, cracked skin among skin diseases. others. Aside from allergic reactions, few severe reactions to calendula have been found in published reports. BACKGROUND OF THE INVENTION 10 Although Calendula oil is readily available from commer cial sources described below, it may also be made from Veg The largest organ of our bodies, the skin is what separates etable, soy or other oils in which 60-80grams of dried cal us from the outside world. It holds body fluids in, preventing endula herb is placed in 1 gallon of the oil and allowed to sit dehydration, and keeps harmful microbes out—without it in the Sun for a natural extraction process for a period of at mammals would succumb to infection. Unfortunately, it is 15 least 3 months. The mixture may be agitated 2 to 7 times a Susceptible to a variety of diseases. Skin diseases include week. This process can be accelerated if demand Surpasses rashes, blisters, acne, fungal infections such as athlete's foot, Supply, using heat extraction, by heating the mixture over a ringworm, burns, insect bites, microbial infections, Sunburn, slow heat from 30 minutes to a period of hours depending Scabies, scrapes and cuts, among many others. Over the years, upon the Volume desired. various compositions have been developed to treat these dis Tea Tree Oil: Teatree oil or melaleuca oil is an essential oil eases. Most of these compositions, however, are only Suitable obtained by steam distillation of the leaves of the Melaleuca for treatment of a single disease. alternifolia tree. The oil is believed to have beneficial cos Accordingly, there is still a need for a composition that may metic and medical properties. It is believed to possess anes be utilized to successfully treat various diseases. thetic, anti-bacterial, antiseptic and anti-fungal properties. As 25 Such, it is valuable as a first aid treatment for a range of SUMMARY OF THE INVENTION complaints. It makes an excellent topical oil to prevent infec tions and accelerate the healing of Small cuts and grazes, and In one aspect, a topical composition for treating skin dis also bruises. It removes the itch and irritation caused by insect eases is provided. The composition comprises calendula, tea bites. Tea tree oil can also be applied to areas of severe tree oil, eucalyptus oil, grape seed oil, and Aloe vera. The 30 composition may also include beeswax, vegetable oil, Vita sunburn to provide relief and prevent blistering. min E. Rosemary oil, or Shea butter. Eucalyptus oil: Eucalyptus oils are obtained by distillation The composition may be presented in the form selected of the leaves of Eucalyptus. The Eucalyptus oils are used for from the group consisting of sticks, bars, gels, lotions, pastes, medicinal, perfumery and industrial purposes. Medicinal oils are characterized by a high eucalyptol content which has been balms, creams and ointments, body washes, face washes, 35 rinses, sprays and oral tinctures. demonstrated to reduce inflammation and pain. The composition may further comprise at least one second Grape Seed Oil: Grape seed oil is a vegetable oil pressed ary active agent. In one embodiment, the secondary active from the seeds of various varieties of Vitis vinifera grapes. It ingredient comprises herbs. Alternatively, the secondary used primarily for its high proanthocyanidin content which active ingredient may be selected from the group consisting 40 is bioflavonoid with a demonstrated anti-oxidant properties. of vitamins, antimicrobial agents, anti-inflammatory agents, Proanthocyanidins are also considered helpful in improving non-steroidal cosmetic soothing agents, skin lightening and preserving the elasticity of skin by stabilizing collagen agents, anti-wrinkle agents, anti-itching agents, antioxidants, and elastin. Accordingly, the grape seed oil is commonly used fragrances, conditioners, and combinations thereof. for treatment of damaged and stressed tissues. It can help skin In another aspect, a kit for treating skin diseases is pro 45 retain the normal structure of epithelium cells and nerve cells vided. It comprises a composition as described above and a via Supporting the cell membranes. set of instructions. In some embodiments, it may also include Aloe Vera: Transparent gel from the pulp of the meaty an applicator for applying the composition to the skin. leaves of Aloe vera has been used topically for thousands of In yet another aspect, a method of treating a skin affected years to treat wounds, skin infections, burns, and numerous by a skin disease in a mammal is provided. Such method 50 other dermatologic conditions. Many of Aloe vera's benefi comprises administering an effective amount of a composi cial properties may be attributed to polysaccharides Such as tion as described above to the affected area. glucomannan and acemannan. In some embodiments, Suit able Aloe vera may be used either in water or oil-based liquid DETAILED DESCRIPTION forms. In other embodiments, water may be added to oil 55 based aloe liquid to adjust the oiliness of the liquid. Applicant has unexpectedly discovered that a composition Beeswax: Beeswax is a product from a beehive, specifi comprising calendula, tea tree oil, eucalyptus oil, grape seed cally the hive of any species of honeybee (the genus Apis). It oil, and Aloe vera is effective in treatment of various skin is purified to remove impurities using well known techniques diseases in mammals. Addition of beeswax, vegetable oil, to produce the commercial product. Vitamin E. Rosemary oil, herbs, Shea butter, or combinations 60 Vegetable oil: Vegetable oils are substances derived from thereof to such composition may further enhance its benefi plants that are composed of triglycerides. The oils are cial effects. extracted from vegetables by chemical extraction or physical Main Ingredients: extraction methods and purified. Examples of vegetable oils Calendula. Calendula is a genus of about 12-20 species of include, but are not limited, to Soybean oil, corn oil, coconut annual or perennial herbaceous plants in the daisy family 65 oil, carrot oil, Sunflower oil, rapeseed oil, peanut oil, castor Asteraceae. Calendula contains chemicals that have been oil, pumpkin seed oil, cottonseed oil, palm oil, sesame oil, or shown in animal studies to speed up wound healing by several combinations thereof. US 7.691,419 B2 3 4 Shea butter: Shea Butter is a natural butter extracted from A person skilled in the art can select both the appropriate the nuts of the Shea tree by traditional techniques, i.e. using presentation form and the method for preparing it on the basis water as an extraction solvent, or using other solvents such as, of his general knowledge, taking into account on the one hand for example, ethanol or hexane. Shea butter is known for its the nature of the constituents used, and on the other hand the properties as a moisturizer and emollient and as an anti intended use of the composition. The compositions may be inflammatory agent. prepared by any method known and practiced in the art. For Vitamin E: The term Vitamin E, Tocopherol, refers to a example, U.S. Pat. Nos. 4,246,285; 4,847,068; 6,927.205: series of organic compounds that include methylated phenols. 5,824,323; 5,143,940; 6,030,931; and 7,186,416, which are Here, the term Vitamin Ealso includes the various derivatives incorporated herein by reference, disclose various skin care of these compounds. Vitamin E is a fat-soluble antioxidant. It 10 compositions in the form of lotions, creams, solutions, gels, is also known to promote healing of skin wounds. foams and Solids. In addition, various Solid formulations of Rosemary Oil: Rosemary essential oil may be extracted gel Stick compositions are disclosed, for example, in U.S. Pat. from Rosemary herb by steam distillation. The main chemical Nos. 4,518.582; 4,719,102; 4,722,835, incorporated herein components of rosemary oil are a-pinene, borneol, b-pinene, by reference. camphor, bornyl acetate, camphene, 1,8-cineole and 15 For example, if the composition is used as a skin moistur limonene. Rosemary oil is used for its many therapeutic prop izer it may preferably, be of an ointment consistency. If the erties such as analgesic, antidepressant, astringent, carmina composition is used as a lip balm the Viscosity of the compo tive, cephalic, cholagogue, cordial, digestive, diuretic, emme sition may preferably be increased to make a firmer product. nagogue, hepatic, hypertensive, nervine, rubefacient, The changes in Viscosity of the composition may beachieved, stimulant, Sudorific and tonic propterties. for example, by adjusting the amount of beeswax among The ingredients described above are readily available com other methods. mercially in various forms from, for example, The Herbarie at The topical compositions may beformulated with liquid or Stoney Hill Farm, Inc. of Prosperity, S.C., or HERBSMD Solid emollients, solvents, thickeners, or humectants. Emol .COM of Torrance, Calif., among many other sources. lients include, but are not limited to, Stearyl alcohol, mink oil, A person skilled in the art should be able to select the 25 cetyl alcohol, oleyl alcohol, isopropyl laurate, polyethylene appropriate amount of ingredients on the basis of his general glycol, olive oil, petroleum jelly, palmitic acid, oleic acid, and knowledge, taking into account on the one hand the nature of myristyl myristate. Emollients may also include natural but the constituents used, and on the other hand the intended use ters extracted from various plants, trees, roots, or seeds. of the composition. For example, adjustments in the propor Examples of such butters include, but are not limited to, shea tions of Tea Tree Oil and Eucalyptus Oil may be decreased, 30 butter, cocoa butter, avocado butter, aloe butter, coffee butter, for example, in conditions where the composition is used as mango butter, or combination thereof. an ear ointment, so as not to cause a tingling or burning Suitable solvents include, without limitation, ethyl alco sensation in severe cases of otits externa, otitis media or otitis hol, isopropanol, acetone, diethylene glycol, ethylene glycol, interna (mild to severe ear infection/inflammation), where dimethyl sulfoxide, and dimethyl formamide. serious ulceration of the area may exist. 35 By way of non-limiting example, a composition may gen Suitable humectants include, but are not limited to, acetyl arginine, algae extract, aloe barbadensis leaf extract, 2.3- erally include from between about 20% to about 65% weight butanediol, chitosan lauroylglycinate, diglycereth-7 malate, per volume of Calendula Oil, from about 0.01% to about 5% diglycerin, diglycol guanidine Succinate, erythritol, fructose, weight per volume of Tea Tree Oil, from about 0.01% to about glucose, glycerin, honey, hydrolyzed wheat protein/polyeth 15% weight per volume of Eucalyptus Oil, from about 0.01% 40 ylene glycol-20 acetate copolymer, hydroxypropyltrimo to about 15% weight per Volume of Grape Seed Oil, and from nium hyaluronate, inositol, lactitol, maltitol, maltose, manni about 0.01% to about 20% weight per volume of Aloe Vera tol, mannose, methoxy polyethylene glycol, Oil. In some embodiments, the composition may also include myristamidobutyl guanidine acetate, polyglyceryl Sorbitol, from about 0.01 to 8% weight per volume of Vitamin E, from potassium pyrollidone carboxylic acid (PCA), propylene gly about 0.00 to 20% weight per volume of Shea Butter, from 45 about 0.01% to about 2% of weight per volume Rosemary oil, col, sodium pyrollidone carboxylic acid (PCA), sorbitol, and from about 0.00% to about 40% weight per volume of bees sucrose. Other humectants may be used for yet additional wax, from about 15% to about 55% weight per volume of embodiments of this invention, as will be appreciated by vegetable oil, from about 0.00% to 40% weight per volume of those skilled in the art. herbs, or combinations thereof. Some embodiments may also 50 Suitable thickeners include, but are not limited to, polysac include white vinegar or gentian violet. charides, in particular Xantham gum, guar-guar, agar-agar, Topical Compositions: alginates, carboxymethylcellulose, relatively high molecular In one embodiment of the present invention, the composi weight polyethylene glycol mono- and diesters offatty acids, tion may be applied on the surface of the affected skin area in polyacrylates, polyvinyl alcohol and polyvinylpyrrolidone, adequate quantity and in the manner conventional in the rel 55 Surfactants such as, for example, ethoxylated fatty acid glyc evant field. The topical composition may be in a solid, semi erides, esters offatty acids with polyols such as, for example, Solid, or liquid form. Suitable solid topical compositions pentaerythritol or trimethylpropane, fatty alcohol ethoxylates include, for example, Sticks or bars similar to deodorant or alkyl oligoglucosides, and electrolytes, such as sodium Sticks. Suitable semi-solid mixtures topical compositions chloride and ammonium chloride. may include, for example, gels, lotions, pastes, balms, creams 60 The composition may further comprise one or more pen and ointments. Suitable liquid topical compositions include, etrants, compounds facilitating penetration of active ingredi for example, body or face washes, rinses, and sprays. Such ents into the skin of a patient. Non-limiting examples of topical compositions are useful for treating skin diseases Suitable penetrants include isopropanol, polyoxyethylene which include, but are not limited to, rashes, blisters, acne, ethers, terpenes, cis-fatty acids (oleic acid, palmitoleic acid), fungal infections, bacterial infections, burns, insect bites, 65 acetone, laurocapram dimethyl sulfoxide, 2-pyrrolidone, microbial infections, Sunburn, Scabies, scrapes, cuts and com oleyl alcohol, glyceryl-3-Stearate, cholesterol, myristic acid binations thereof. isopropyl ester, and propylene glycol. US 7.691,419 B2 5 6 Additionally, the compositions may include Surfactants or In one preferred embodiment, the composition is in the emulsifiers for forming emulsions. Either a water-in-oil or tincture form. Tinctures are herbal extracts. They may be oil-in-water emulsion may be formulated. Examples of Suit prepared by using solvents to extract oils from herbs by either able emulsifiers include, but are not limited to, stearic acid, percolation or maceration techniques. Suitable solvents may cetyl alcohol, PEG-100, stearate and glyceryl Stearate, cet include, but are not limited to, water, glycerin, propylene earylglucoside, polysorbate 20, methylcellulose, Sodium car glycol, alcohol, vegetable oil, mineral oil, or combinations boxymethylcellulose, glycerin, bentonite, ceteareth-20, cetyl thereof. Processes for preparing tinctures are well known in alcohol, cetearyl alcohol, lanolin alcohol, riconyl alcohol, the art and are disclosed, for example, in U.S. Pat. No. 4,952, self-emulsifying wax (e.g., Lipowax P), cetyl palmitate, 603 ElFerally, et al., and U.S. Pat. Nos. 6,555,074 and 6,656, Stearyl alcohol, lecithin, hydrogenated lecithin, Steareth-2, 10 437 to Sweet, which are incorporated herein in their entirety. Steareth-20, and polyglyceryl-2 Stearate. Furthermore, tinctures are available commercially from com In some formulation, such as in aerosol form, the compo panies indicated above. sition may also include a propellant. Preferably, hydrofluo Secondary Active Ingredients: roalkanes (HFA) such as either HFA 134a (1,1,1,2,-tetrafluo In some embodiments, in addition to the ingredients dis roethane) or HFA 227 (1,1,1,2,3,3,3-heptafluoropropane) or 15 closed above, secondary active agents may be included into combinations of the two, may be used since they are widely the present compositions. In some embodiments, such sec used in medical applications. Other Suitable propellants ondary active ingredient may include herbs in concentrations include, but are not limited to, mixtures of volatile hydrocar of between about 0.01% and about 40% weight per volume. bons, typically propane, n-butane and isobutane, dimethyl Examples of herbs include, but are not limited to Chinese ether (DME), methylethyl ether, nitrous oxide, and carbon herbs and other herbs such as Althea officinalis, Bei xi xin, dioxide. Ashwagandha, Beixie, Ali Pian, Bei Zicao, Annan Zi Bixie, Those skilled in the art will readily appreciate that emol An Xi Xiang, Bian dou, Ba dou, Bian xu, Badou rou, Bieia, lients, solvents, thickeners, humectants, penetrants, Surfac Baji; Canger Cao, Baji tian, Canger zij Bajiao wu tong, tants or emulsifiers, and propellants, other than those listed Cang Zhu, Bai ai; Caoguo, Baibu, Cao long dan, Baiguo, may also be employed. 25 Cao wu, Bai he, Chai hu. Baiji; Chan tui Baiji li; Chang Oral Compositions: Shan, Baijuezi. Chenpi, Baiju hua, Chongcao, Bai longgu, Chi Zhu, Baimao gen, Chuan beinu, Baiqian, Chuan duan, The compositions may also be administered orally either in Bai Shao, Chuan fu Zi Bai Shaoyao, Chuan gao ben, Bai Solid or a liquid form. For oral administration, the composi shen, Chuan honghua, Baitou weng, Chuan huang bai, Bai tions may be presented in the form of tablets, lozenges, pills, 30 weigen, Chuan lian, Baixian pi; Chuan lian zi; Bai Zhi, capsules, elixirs, powders, lyophilized powders, Solutions, Chuan mu tong, Baizu, Chuan yujin, Ban bian lian, Chuan granules, suspensions, emulsions, syrups, and tinctures. Con zu, Ban la gen, Chuan Xiong, Ban mao, Chunhua, Ban xia, ventionally known methods may be used to prepare the com Chun pii Ban Zhi lian, Cun dong, Bei he shi; Cordyceps position in different forms. Sinensis, Da beinu, Beilian qiao, Da Chong Zuangjuan, Bei Solid forms for oral administration may contain binders 35 qi Da huang, Bei wu weizi Daji, Dama ren, Feizi Dasha acceptable in human and Veterinary pharmaceutical practice, shen, Fen dan pii Da Suan, Fangfang, Da Zao, Fu hai she, Sweeteners, disintegrating agents, diluents, flavourings, coat Dan Cao, Fu hua, Dan pii Fu ling, Dan qin, Fu ling pi; Dan ing agents, preservatives, lubricants and/or time delay agents. sha, Fu pen zi; Dan Shen, Fu She, Dangguishen, Fu xiao Suitable binders include, but are not limited to gum acacia, mai; Danggui tou, Fu zi; Danggui tou, Gian cao, Danggui gelatine, corn starch, gum tragacanth, Sodium alginate, car 40 wei, Gian dihuang, Danggui, Gandi long, Dangshen, Gan boxymethylcellulose or polyethylene glycol. Suitable sweet ge gen, Dibie chong, Gangen, Diding, Ganjiang Digu pi; eners include, but are not limited to. Sucrose, lactose, glucose, Gian jiu hua Di long Gian qi. Dingfeng cao Gan Shi Dong aspartame or saccharine. Suitable disintegrating agents chongcao Gao ben Dongchongxia cao Gao lishen Donggua include, but are not limited to, corn starch, methylcellulose, ren Gegen Donghua Gejie Du huo Gou qizi Dou chi Gua polyvinylpyrrolidone, guar gum, Xanthan gum, bentonite, 45 di Du Zhong Gua lou Shi Dong Zhu Guan gui, Eguan Shi alginic acid or agar. Suitable diluents include, but are not Guan huang bai, Ejiao Guan mu tong, E Zhu Guangyuji Er limited to, lactose, Sorbitol, mannitol, dextrose, kaolin, cel cha Guangzhi mu, Er chou Giu ban Erhua-Guiban jiao Fa lulose, calcium carbonate, calcium silicate ordicalcium phos banxia Haier Shen Fanxieve, Han, Fang dang Hangju hua phate. Suitable flavouring agents include, but are not limited Fangfeng He shou wu, Fangii, Hei xuan Shen Fang ling kuai to, peppermint oil, oil of wintergreen, cherry, orange or rasp 50 Hong hua Fei Zhi mu, Hong Shen Fen dan pii Hong sixian berry flavouring. Suitable coating agents include, but are not Fengfang Houjiang Fengguo Hou po Fo Shou hua Hugu, limited to, polymers or copolymers of acrylic acid and/or Huihuang lian Lian ren Hua Shidan Lian rou Huaihua Lian methacrylic acid and/or their esters, waxes, fatty alcohols, Shi Huai mi: Lian ren Huangbo, Lian Xu Huangdan Lianxin Zein, shellac or gluten. Suitable preservatives include, but are Huang lian Ling cishi Huang qi Ling xian gen Huang qin not limited to, sodium benzoate, Vitamin E, alpha-tocopherol, 55 Lingyangjiao Huangyao Zi-Liu huang Huo maren Liu jinu, ascorbic acid, methyl paraben, propyl paraben or sodium Ji Cai Liu jinu Cao Ji neiji; Long dan Jilin Shen Long dan Cao bisulphite. Suitable lubricants include, but are not limited to, Ji Zhiun pi; Longgu, Juan beinu, Long hu Cao Jiang huang magnesium Stearate, Stearic acid, sodium oleate, sodium Longyan rou Jiang banxia Lou ren Jiangjun Lu bazi, Jiang chloride or talc. Suitable time delay agents include glyceryl jun Lu dangshen Jie geng Lufengfang Jie Sui Lu hui Jingeng monostearate or glyceryl disteaae. 60 Lujiaojiao Jin gian cao Lupijiao Jin wen Lurong Jinyin hua Liquid forms for oral administration may contain, in addi Luo hanye, Ju hua Luo Shuichen Jun Zi Ma huang Kong sha tion to the above agents, a liquid carrier. Suitable liquid car Shen Ma huanggen Kuding xiang Maidong Ku lian pi; Mai riers include, but are not limited to, water, oils such as olive men dong Ku qin Manjing shi Ku Shen Manjing Zi, Kun bu; oil, peanut oil, sesame oil, Sunflower oil, safflower oil, arachis Mao hua Kun Cao Mao Zhu Lai fi Zi, Moyao Lancao Ming oil, coconut oil, liquid paraffin, ethylene glycol, propylene 65 tian ma, Lao sang Zhi Mu dan pi; Leiwan Mu fangji, Lilu, glycol, polyethylene glycol, ethanol, propanol, isopropanol, Mu bei Zi Li Zhi he, Mu tong Lian fang Mu xiang Lian peng glycerol, fatty alcohols, triglycerides or mixtures thereof. Nan wu weizi, Lianqiao Nanxing Nao Zi; Sangji Sheng Nei US 7.691,419 B2 7 8 in Sang piao Xiao Nen qin Sangshen Ning Shui Shi Sangshen Additionally, the designer of the product can use vitamins, zii Nui zi; Sangye, Oujie Sang Zhi Pang da hui Sharen Pao antimicrobial agents, anti-inflammatory agents, non-steroi jiang Sharenke, Penge Zhu Shayuan jili, Peng Zhu Shan dou dal cosmetic Soothing agents, skin lightening agents, anti gen Pipa ve. Shan qi. Pianjiang huang Shan Shen Pian qin wrinkle agents, anti-itching agents, antioxidants, fragrances, Shan yao Pogu Zhi Shanyu rou Pu huang Shan Zhizi Oi ai; conditioners, and other agents or any combination thereof. Shang lu, Qilin jie Shenjiang Qizi. Shen San qi. Ouan Cao Those skilled in the art will readily appreciate that substances Shengdi, Qian Caogen-Sheng dihuang Oian dan Shengjiang other than those listed in the non-limiting examples below Oian hu. Sheng ma, Oiang huoeng Sheng Shai Shen Qin pi; may also be employed. Sheng tie luo Qin jiao Shigao Qinghao Shiliu hiang Qingpi; Non-limiting examples of useful vitamins include, but are 10 not limited to, Vitamin A, vitamin B-B, biotin, vitamin C, Shizhi Cao Qiu chaihu, Shou wu, Ou mai Shi di Ouan chong pantothenic acid, vitamin K. Vitamin D. Vitamin E and mix Shu di huang Quan danggui Shujiao Quan gua lou Shu in tures thereof. Non-limiting examples of useful antimicrobial teng Quan Xie Shuanghua Ren doing ha, Shuangsangye, Ren agents include, but are not limited to, beta-lactam drugs, Shen Su he xiang Renshen lu, Suan Zao ren Ren Shenye, Tai quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, Zishen Rou congrong Tangshen Roudou kou Tao ren Rougui 15 erythromycin, amikacin, 2.4,4'-trichloro-2'-hydroxy diphe Tian dong Ruan chaihu, Tiangua di San qi. Tian ma; San qi nyl ether, 3,4,4'-trichlorobanilide, phenoxyethanol, phenoxy hua Tian ma jiao Sang baipi; Tian men dong Sanggen baipi; propanol, phenoxyisopropanol, doxycycline, capreomycin, Tianqi, Sangji, Tiaoqin Tufi ling, Xing tou Cao, Tong Shen, chlorhexidine, chlortetracycline, oxytetracycline, clindamy Xiong dan, Tongjili, Xiong qiong Tugou qi, Xu duan Tu niu cin, ethambutol, hexamidineisethionate, metronidazole, pen xi Xuan hu; Tusi, Xuan hu Suo Tuoli Cao Xuan Shen Wa leng tamidine, gentamicin, kanamycin, ketoconazole, lineomycin, Xue danshen Wa long Zi, Xuejie Weigen Xue po, Weijing Ya methacycline, methenamine, minocycline, neomycin, danzi Wei lian Yalian Weiling xian Yan hu: Wen Zhu Yan hu netilmicin, paromomycin, streptomycin, tobramycin, suo Wu bei Zi, Yang huo Wu gong Yejiao teng Wu hua longgu, miconazole, tetracycline hydrochloride, erythromycin, Zinc Yeju, Wu ling Zhi Yeju hua Wu mei Yiren Wu tou Yi viren Wi erythromycin, erythromycin estolate, erythromycin Stearate, weizi, Yizhi ren Wuyue ai, Yin chai hu. Wu Zeigui Yinchen 25 amikacin Sulfate, doxycycline hydrochloride, capreomycin hao Xi chaihu, Yin er: Xigua Yinguo ye, Xihonghua Yin hu. sulfate, chlorhexidine gluconate, chlorhexidine hydrochlo Xihuang Yin hua Xijiao Yinxing Xixiang ru, Yinyang huo Xi ride, chlortetracycline hydrochloride, oxytetracycline hydro Xin Yinyang lian Xiyang Shen Ying chai hu, Xia ku Cao Ying chloride, clindamycin hydrochloride, ethambutol hydrochlo chunhua Xian he cao Yu baifi, Xian lingpi, Yuguo Xian mao ride, metronidazole hydrochloride, pentamidine Yujin Xiang baizhi Yu liren Xiang bei Yu Zhu Xiang chi Yuan 30 hydrochloride, gentamicin Sulfate, kanamycin Sulfate, line cun xiang Xianggao ben Yuan hu, Xiang gua di Yuan Shen omycin hydrochloride, methacycline hydrochloride, meth Xiao hui Yuan wei ban Xie ye, Yuan wu ban Xie bai Yuan Zhi enamine hippurate, methenamine mandelate, minocycline Xinyi. Yueyue hong Xin vihua Yun lian Xing ren Yun ling hydrochloride, neomycin Sulfate, netilmicin Sulfate, paromo Zang honghua Zaojiao, Zao pii Zelan Zeqi, Ze xie Zhang mycin Sulfate, Streptomycin Sulfate, tobramycin Sulfate, nao Zhe bei Zhe bei mu, Zhe chong Zheshi Zhenzhu Zhi ke; 35 miconazole hydrochloride, amanfadine hydrochloride, Zhiinu, Zhimu rou Zhinan xing Zhizi; Zhuerqing Zhu huang amanfadine Sulfate, octopiroX, parachlorometa Xylenol, nys Zhu li; Zhu ling Zhu sha Zhuye, Zhu you Zi beifi ping Zi bei tatin, tolnaftate, Zinc pyrithione; clotrimazole; alantolactone; tian kui Zicao Zi Caogen Zidan Shen Zidi ding Zimu tong Zi isoalantolactone; alkanet extract (alaninin); anise; arnica ran tong Zisu vei Zisu Zi Ziwan Zizhu Zi Zhu Cao Zong lu extract (helenalin acetate and 11, 13 dihydrohelenalin); Di. 40 Aspidium extract (phloro, lucinol containing extract); bar Additional herbs include, but are not limited to, herbs such berry extract (berberine chloride); bay sweet extract; bay as Ashwagandha, Artemisia sp., Angelica sp., Burdock root berry bark extract (myricitrin); benzalkonium chloride; ben (Arctium lappa), Blessed thistle (Cerbenia benedicta), Bro Zethonium chloride; benzoic acid and its salts; benzoin, melain, Boswellia serrata, Cameliaaia sinensis, Cayenne benzyl alcohol; blessed thistle; bletilla tuber; bloodroot; bois (Capsicum anuum), Cat's claw, Chapareal (Larrea divari 45 de rose oil; burdock; butyl paraben; cade oil; CAE (available cata), Cinchona sp., Comfrey (Symphytum officinale), Dal from Ajinomoto, located in Teaneck, N.J.), cajeput oil; Cang mation (Sage sp), Dandelion (Taraxacum sp.), Devil's claw Zhu: capsicum frutescens extract; caraway oil; cascarilla bark (Harpagophytum procumbens), Echinacea angustifolia, (sold under the tradename ESSENTIAL OIL); cedarleaf oil; Eluthero, Eucalyptus globulus, Euphrasia, Eyebright (Eu chamomille; chaparral; chlorhexidine gluconate; chlo phrasia officinalis), Fennel (Foeniculum vulgare), Fenugreek 50 rophenesin; chlorXylenol; cinnamon oil; citronella oil; clove (Trigonella foenumgraecum), Feverfew (Pyrethrum parthe oil; Crinipan AD (available from Climbazole); 2.3-dihydro nium), Frankincense, Gentian root (Gentiana lutea), Ginger farnesol; dehydroacetic acid and its salts; dill seed oil; (Zingiberis officinalis), Ginko leaf/root, Goldenseal (Hydras DOWICIL 200 (available from Dow Chemical, located in tis Canadensis), Gotu kola (Centella asiatica), Guggal (Com Midland, Mich.); echinacea; elenolic acid; epimedium; ethyl miphora mukul), Horehound (Marrubium vulgare), Hyssop 55 paraben: Fo-Ti; galbanum; garden bumet: GERMALL 115 (Hyssopus officinalis), Kavakava (Piper methysticum), Lico and GERMALL II (available from ISP-Sutton Labs, located rice root (Glycyrrhiza sp.), Lobelia inflata, Meadowsweet in Wayne, N.J.); German chamomile oil; giant knotweed; (Filipendula ulmaria), Mughal garam, Mullein (Verbascum GLYDANT (available from Lonza, located in Fairlawn, N.J.); tapsus), Myrrh (Commiphora nayrrha), Nettle (Urtica GLYDANT PLUS (available from Lonza); grapefruit seed urens), Partridge berry (Mitchella repens), Pennyroyal (Men 60 oil; 1.6 hexanediol; hexamidine diisethionate; hinokitiol; tha pullegium), Periwinkle, Plantain (Plantago psyllium), honey; honeysuckle flower, hops; immortelle; iodopropynl psyllium, Pueraria flower, Rehmannia root, Rosemary (Ro butyl carbamide (available from Lonza); isobutyl paraben; Sarinus officinalis), Silybum sp. (Milk thistle), Scuttelaria isopropyl paraben; JM ACTICARE (available from Micro (Skullcap), Slippery elm (Ulmus filva), St. john’s wort (Hy bial Systems International, located in Nottingham, NG): juni pericum perforatum), Tumeric, Uva ursi (Arctostaphylos sp), 65 per berries; KATHON CG (available from Rohm and Haas, Valerian (Valerian sp.), Wild yam root (Dioscorea villosa), located in Philadelphia, Pa.): kojic acid; labdanum; lavender; Yarrow (Achillea millefolium), Yellowdock (Rumex crispus) lemon balm oil; lemon grass; methyl paraben; mint, mume; US 7.691,419 B2 9 10 mustard; myrrh, neem seed oil; ortho phenyl phenol; olive ture), mints, mistletoe, Modulene (available from Seporga), leaf extract (available from Bio Botanica); parsley; patchouly mono or diglucosides of glabridin, mono or diglucosides of oil; peony root; 1.2 pentandiol; PHENONIP (available from gentisin, MTA (5'-deoxy-5'-methylhioadenosine), mung Nipa Labs, located in Wilmington, Del.); phenoxyethanol: bean extract, musk, N-methyl arginine, oat beta glucan, oat phytosphingosine; pine needle oil; PLANSERVATIVE extract, orange, panthenol, papain, phenoxyacetic acid, (available from Campo Research); propyl paraben; purslane; peony bark, peony root, Phytoplenolin (available from Bio quillaira, rhubarb; rose geranium oil; rosemary; Sage; Sali Botanica), phytosphingosine, Preregen (available from Pen cylic acid; Sassafras; Savory; Sichuan lovage; Sodium meta tapharm), purslane, QUENCH T (available from Cen bisulfite: sodium sulfite; SOPHOLIANCE (available from terchem), quillaia, red sage, rehmannia, rhubarb, rosemary, Soliance, located in Compiegne, France); Sorbic acid and its 10 roSmarinic acid, royal jelly, rue, rutin, Sandlewood, Sandi, salts; sphingosine; Stevia; storax; Sucrose esters; tarmic acid; sarsaparilla, saw palmetto, SENSILINE (available from tea; tea tree oil (cajeput oil); thyme; triclosan; triclocarban; Silab), SIEGESBECKIA (available from Sederma), stearyl tropolone; turpentine; umbelliferone (antifungal), yucca; and glycyrrhetinate, Stimutex (available from Pentapharm), sto mixtures thereof. rax, strontium nitrate, Sweet birch oil, Sweet Woodruff, tag Non-limiting examples of anti-inflammatory agents useful 15 etes, tea extract, thyme extract, tienchi ginseng, tocopherol, herein include, but are not limited to, hydrocortisone, non tocopheryl acetate, triclosan, turmeric, urimei, ursolic acid, steroidal anti-inflammatory agents such as oxicans, salicy white pine bark, witch hazel Xinyi, yarrow, yeast extract, lates, acetic acid derivatives, fenamates, propionic acid yucca, and mixtures thereof. derivatives, pyrazoles, Substituted phenyl compounds, Non-limiting examples of anti-itch ingredients useful 2-naphthyl containing compounds, hydrocortisone, triamci herein include, but are not limited to, Stimu-tex (available nolone acetonide and natural anti-inflammatory agents such from Pentapharm); Takanal (available from Ikeda-Distrib as aloe Vera. Examples of anti-inflammatory agents are uter); Ichthyol (available from International Sourcing-Dis described in U.S. Pat. No. 5,487,884, the entire content of tributor); Oxygenated Glyceryl Triesters (available from which is incorporated herein by reference. A preferred anti Seporgia); hydrocortisone; Pramoxine and mixtures thereof. inflammatory agent used in the practice of the invention is 25 Non-limiting example of antioxidants useful herein triamcinolone acetonide. include, but are not limited to, vitamin E, tocopheryl acetate, Non-limiting examples of useful cosmetic soothing agents betaglucan, coenzyme Q10, butylated hydroxy toluene include, but are not limited to, acetyl salicylic acid, ibuprofen, (BHT), butylated hydroxy anisole BHA, superoxide dismu naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, tose, propylgallate, and the like. ketoprofen, indoprofen, pirprofen, carprofen, Oxaprozin, pra 30 Non-limiting examples of useful skin conditioners include, noprofen, miroprofen, tioxaprofen, Suprofen, alminoprofen, but are not limited to, mineral oil, petrolatum, vegetable oils tiaprofenic acid, flu profen, bucloxic acid, absinthium, aca (such as soybean or maleated soybean oil), dimethicone, cia, aescin, alder buckthorn extract, allantoin, aloe, APT dimethicone copolyol, cationic monomers and polymers (available from Centerchem), amica, astragalus, astragalus (such as guar hydroxypropyl trimonium chloride and dis root extract, azulene, Baicalin SR 15 (available from Barnet 35 tearyl dimethyl ammonium chloride) as well as combinations Products Dist.), baikal skullcap, baizhu, balsam canada, bee thereof. Illustrative moisturizers are polyols such as sorbitol, pollen, BIOPHYTEX (available from Laboratories Serobi glycerin, propylene glycol, ethylene glycol, polyethylene ologiques), bisabolol, black cohosh, black cohosh extract glycol, polypropylene glycol, 1,3-butane diol, hexylene gly blue cohosh, blue cohosh extract, boneset, borage, borage oil, col, isoprene glycol, Xylitol, fructose and mixtures thereof. bradykinin antagonists, bromelain, calendula, Calendula 40 Kits: extract, Canadian Willowbark Extract (available from In another aspect, a kit for treating skin conditions is pro Fytokem), candelilla wax, Cangzhu, canola phytosterols, vided. According to one embodiment, the invention com capsicum, carboxypeptidase, celery seed, celery stem extract, prises a container containing a composition comprising cal CENTAURIUM (available from Sederma), centaury extract, endula, tea tree oil, eucalyptus oil, grape seed oil, and aloe chamaZulene, chamomile, chamomile extract, chaparral, 45 vera. A person skilled in the art will be able to select a chaste tree, chaste tree extract, chickweed, chicory root, container based on the form of the composition and its chicory root extract, chirata, chishao, collodial oatmeal, com intended use. For example, an aerosol spray may be supplied frey, comfrey extract, CROMOIST CMGLUCAN (available in a pressurized can, whereas a lotion may be provided in a from Croda), darutoside, dehurian angelica, devil's claw, plastic bottle. In some embodiments of the kit, an applicator, divalent metals (such as, magnesium, strontium, and manga 50 Such as a gauze, a cotton Swab or a brush, may also be nese), doggrass, dogwood, Eashave (available from Pentap included. harm), eleuthero, ELHIBIN (available from Pentapharm), In addition, a set of instructions is provided. The set of ENTELINE 2 (available from Secna), ephedra, epimedium, instructions preferably includes information necessary for esculoside; ethacrynic acid, evening primrose, eyebright, proper use of the kit, such as dosage and timing of adminis Extract LE-100 (available from Sino Lion), Fangfeng, fever 55 tration of the composition disclosed herein. The set of instruc few, ficin, forsythia fruit, Fytosterol 85 (available from tion may comprise instructions on treating skin diseases Such Fytokem), ganoderma, gaoben, Gatuline A (available from as rashes, blisters, acne, fungal infections, burns, insect bites, Gattefosse), gentian, germanium extract, gingko billboa microbial or infections, Sunburn, Scabies, scrapes, cuts Surgi extract, ginkgo, ginseng extract, goldenseal, gorgonian cal incisions, skin irritations, chapped lips, cracked skin and extract, gotu kola, grapefruit extract, guaiac wood oil, guggal 60 combinations thereof. A person of ordinary skill in the art will extract, helenalin esters, henna, honeysuckle flower, hore appreciate that the set of instructions can be in any Suitable hound extract, horsechestnut, horsetail, huzhang, hypericum, medium, including, without limitation, printed, video-taped, ichthyol, immortelle, ipecac, job’s tears, jujube, kola extract, digital, and audio-recorded. LANACHRYS 28 (available from Lana Tech), lemon oil, Methods for Treatment Skin Diseases: lianqiao, licorice root, ligusticum, ligustrum, lovage root, 65 The kit provides a practitioner with many of the tools lufa, mace, magnolia flower, manjistha extract, margaspidin, necessary to treat skin affected by a skin disease. These meth matricin, melatonin, MICROAT IRC (available from Nur ods comprise administering an effective amount of composi US 7.691,419 B2 11 12 tion as described above to the effected skin. Skin diseases that Twenty-four hours after treatment started the swelling and can be treated by these methods include, but are not limited to, inflammation was resolved. The owner said, “It’s like a rashes, blisters, acne, fungal infections such as athlete's foot, miracle, the Swelling is down, overnight the paw was better. ringworm, burns, insect bites, microbial infections, Sunburn, There was no need for the e-collar at any time. Scabies, scrapes, cuts, and combinations thereof. The terms “treat”, “treatment' or “treating refer to execut Example 3 ing a protocol, which may include administering one or more drugs to a patient (human or otherwise), in an effort to alle 'Ares, a 3 yr Old Male, Intact, Portuguese Waterdog viate sighs or symptoms of the disease. Alleviation can occur prior to signs or symptoms of disease appearing, as well as 10 Dog was in a fight with another dog that resulted in a 4 cm after their appearance. Thus, “treat”, “treating or “treat long wound on the leg. The wound required debridement ment includes “prevent”, “preventing or “prevention' of under anesthesia. Applying the composition topically 3-4 the disease. In addition, “treat”, “treating or “treatment 99 times a day for the next 7 days resulted in a completely healed does not require complete alleviation of signs or symptoms, area without any evidence of infection, odor, Swelling or does not require a cure, and specifically includes protocols 15 inflammation at any time. which have only a marginal effect on the patient. The term “effective amount’ means a quantity of an agent Example 4 which, when administered to a patient or subject, is sufficient to result in an improvement in patient’s condition. The “Zoe'; a 7 yr old, Female, Intact, DSH (Domestic improvement maybe determined in a variety of ways. Addi Short Haired) Feline tionally, the improvement does not mean a cure and may include only a marginal change in patient’s condition. Presented with a puncture wound of unknown origin A person with ordinary skill in the art will undoubtedly be located along the caudal dorsum at the midline level. The capable of determining the effective amount of the composi Surrounding tissue was injured as noted by the purple, black tion needed for a particular treatment. Such amount may 25 & blue discoloration. Composition was applied topically 2-3 depend on the strength of the composition or extent of the times a day. As a result of this patient being hospitalized due disease. Although a person with ordinary skill in he art will to the placement of a /4 inch Penrose drain, assessment of the know how to select a treatment regimen for a specific condi wound was possible on a daily basis. Observations showed tion, preferably, the composition may be applied 2 to 3 times that within 24 hrs the skin bruising and discoloration was a day or 3 to 4 times a day. It is foreseeable in some embodi 30 improving significantly. Skin Swelling was decreased and ments that the composition is administered over a period of discharge from the puncture had stopped. Within 72 hours the time. The composition may be applied for a day, multiple drain was pulled and the Swelling and inflammation was days, a week, multiple weeks, a month, or even multiple approximately 75% reduced. At no time did “Zoe' attempt to months in severe circumstances. Alternatively, the composi remove the drain or interfere with the healing process. tion may be applied only once when the skin condition is 35 Example 5 mild.

EXAMPLES “Kuma'; a 13 yr Old, Male, Neutered, Akita Presented with chronic “hotspots” (acute moist dermatitis) Example 1 40 of many years duration. Severely swollen, irritated and inflamed digits and paws were present with a deep pyoderma “Dublin': a 11 yr Old, Male, Neutered, Doberman (deep skin infection) of all the paws and digits. All paws were extremely red, weeping with a strong odor. The owners were Anal mass (hepatoid/perianal) adenoma approximately 3 told to apply the composition topically a minimum of four cm.x2 cm was removed. Composition was applied to incision 45 2-3 times a day. 4 days post-op incision looked great. Inflam times a day, noting that the more contact time on the effected mation and Swelling completely resolved. Dog has not skin the better the response. This situation had been going on attempted to bite or lick at incision site due to the salves a number of years and was chronic and quite severe. ability to decrease the irritation, inflammation and Swelling Example 6 that usually comes along with the healing of a Surgical inci 50 Sion. 3 week post-op exam showed complete resolution of “George'; a 11 yr Old, Male, Neutered, DSH incision site and the beginnings of hair regrowth. At no time did this dog attempt to pull out Stitches from the Surgical site. Presented with a distribution of pustules and scabs under his ventral chin of 6 months duration. He was diagnosed with Example 2 55 Feline Acne. Treatment involved topical application of the composition liberally to the effected areas 2-4 times a day. “Minx”: a 1/2 yr Old Domestic Short Haired (DSH) The entire area was healed at the re-examination 10 days Cat, Male, Neutered latter. The owner commented that George did not scratch or rub the area during the treatment period. Presented with right forelimb lameness of 2 weeks dura 60 tion. Swelling developed, according to the owner, four days Example 7 after the lameness started. Minx was constantly licked at this paw. He was taken to the local veterinarian who put him on “Sasha'; a 9 yr Old, Male, Neutered, Yorkshire antibiotics and placed an e-collar on him to prevent him from Terrier touching the leg. After examination at hospital, it was noted 65 that an insect bite or spider bite was the cause of the problem. Presented with severe puriritis (itching) and generalized Composition was prescribed topically 2-3 times a day. hair loss as a result of allergic skin disease. The skin between US 7.691,419 B2 13 14 the digits had numerous Superficial abrasions and ulcerations. to the illustrative embodiments and that other arrangements Serum was oozing from the nail beds indicating possible may be devised without departing from the spirit and scope of bacterial or fungal infection. The composition was applied the present invention as defined by the appended claims. liberally and topically to all the effected areas of skin 2-3 What is claimed is: times a day. Within 4 days the inflammation was significantly 1. A method of treating skin affected by a skin disease in a improved and the ulcerations were 80% healed. mammal comprising: identifying a Subject having an area of skin affected by a Example 8 skin disease selected from the group consisting of rash, blister, fungal infection, burn, bacterial infection, insect “Bunkers'; a 8 yr Old, Male, Neutered, Dalmatian 10 bite, microbial infection, Sunburn, Scrape, cut, Surgical incision, skin irritation, chapped lips, cracked skin, der Presented with a raised, inflamed, swollen skin lesion that matitis and combinations thereof, and resulted from an engorged brown dog tick that was attached to administering to the affected area of the patient's skin an the skin. The tick was removed but the mouths parts of the tick effective amount of a composition consisting of 20% to were embedded in the skin. These were subsequently excised. 15 about 65% weight per volume of Calendula Oil, from The composition was applied topically 2-4 times a day. The about 0.01% to about 5% weight per volume of Tea Tree swelling and inflammation resolved completely by day 2. The Oil, from about 0.01% to about 15% weight per volume dog did not attempted to remove the composition or lick it off of Eucalyptus Oil, from about 0.01% to about 15% indicating that pain, discomfort or itching were not present. weight per volume of Grape Seed Oil, and from about Example 9 0.01% to about 20% weight per volume of Aloe Vera Oil, from about 0.01 to 8% weight per volume of Vitamin E, from about 0.00 to 20% weight per volume of Shea “Catie': a 7 yr Old, Female, Spayed, Collie Butter, from about 0.01% to about 2% of weight per volume Rosemary oil, from about 0.00% to about 40% Presented with a laceration of the front medial pad and 25 Surrounding tissues. Composition was applied topically 2-4 weight per volume of beeswax, from about 15% to about times a day and resolved within a week. No infection, swell 55% weight per volume of vegetable oil and from about ing or inflammation developed. Owner was able to apply 0.00% to about 40% weight per volume of herbs. composition easily to area. 2. The method of claim 1, wherein the skin disease is fungal infection, bacterial infection, microbial infection or a combi Example 10 30 nation thereof. 3. A method of treating skin affected by a skin disease in a “Jax'; a 5 yr Old, Male, Intact, Ferret mammal comprising: identifying a Subject having an area of skin affected by a Presented with superficial abrasions and ulcerations of the skin disease selected from the group consisting of rash, inguinal areas as a result of urine scald. This was the result of blister, fungal infection, burn, bacterial infection, insect the acidic nature of urine and its ability to burn the skin if not bite, microbial infection, Sunburn, Scrape, cut, Surgical washed off and treated. The patient was treated 3 times a day incision, skin irritation, chapped lips, cracked skin, der for 1 week and entire skin regrowth occurred. The composi matitis and combinations thereof, and administering to tion could potentially have a similar effect with human burn 40 the affected area of the patient’s skin an effective amount victims. of a composition consisting of 20% to about 65% weight per volume of Calendula Oil, from about 0.01% to about Example 11 5% weight per volume of Tea Tree Oil, from about 0.01% to about 15% weight per volume of Eucalyptus “Tootsie’: a 8 Months Old, Female, Spayed, Beagle Oil, from about 0.01% to about 15% weight per volume 45 of Grape Seed Oil, and from about 0.01% to about 20% Presented because of a self-inflicted wound that resulted weight per volume of Aloe Vera Oil, from about 0.01 to from constant licking at her front paw. There are various 8% weight per volume of Vitamin E, from about 0.00 to medical and non-medical reasons why a pet might do this, 20% weight per volume of Shea Butter, from about however, the result in this case was ulceration and Subsequent 0.01% to about 2% of weight per volume Rosemary oil, infection of the skin between the toes (interdigital dermatitis). 50 from about 0.00% to about 40% weight per Volume of Salve was applied 3-4 times a day and complete resolution beeswax, from about 15% to about 55% weight per occurred within 5 days. volume of vegetable oil, from about 0.00% to about 40% Although the invention herein has been described with weight per Volume of herbs, water, and an emulsifier. reference to particular embodiments, it is to be understood 4. The method of claim 3, wherein the composition is in a that these embodiments are merely illustrative of the prin 55 form of water-in-oil or oil-in-water emulsion. ciples and applications of the present invention. It is therefore to be understood that numerous modifications may be made