Table S1. List of all presented as fold change in Figure 1C of BLC vs CD20+, BLC vs CD20-, and CD20- vs CD20+.

Log2 Fold change Gene discription BLC vs CD20+ BLC vs CD20- CD20- vs CD20+ ACP5 Acid phosphatase 5, tartrate resistant -7,311 -5,670 -1,641 ADA Adenosine deaminase 2,571 0,511 2,060 BCL10 B-cell CLL/lymphoma 10 -1,230 -0,160 -1,070 CAPN1 Calpain 1, (mu/I) large subunit -1,091 -1,076 -0,015 CAPN2 Calpain 2, (m/II) large subunit -7,865 -8,678 0,813 CD63 CD63, lysosome-associated membrane glycoprotein 1,557 -0,013 1,570 CTNS Cystinosin, lysosomal cystine transporter -1,157 -0,996 -0,162 CTSC Cathepsin C 4,297 2,484 1,813 CTSD Cathepsin D 2,057 -0,618 2,674 CTSH Cathepsin H -1,534 -1,428 -0,106 CTSK Cathepsin K -1,964 -3,386 1,423 CTSL Cathepsin L1-like 6,783 -0,721 7,504 CTSS Cathepsin S -1,691 -1,899 0,208 CTSW Cathepsin W 3,639 -4,101 7,739 CYB561A3 cytochrome b ascorbate-dependent 3-like -2,098 -0,093 -2,005 DRAM2 DNA-damage regulated autophagy modulator 2 -0,991 -0,236 -0,755 FASLG Fas ligand (TNF superfamily, member 6) 3,379 -0,061 3,440 GAA Glucosidase alpha acid 1,516 1,294 0,222 GLMP Lysosomal protein NCU-G1-like 1,727 0,726 1,001 GNS Glucosamine (N-acetyl)-6-sulfatase 1,399 1,034 0,365 HPSE Heparanase -3,266 -5,381 2,115

LAMP2 Lysosomal-associated 2 1,317 1,005 0,312 LAMP3 Lysosomal-associated membrane protein 3 6,380 6,592 -0,212 LDLR Low density lipoprotein receptor 3,475 1,379 2,096 LGMN Legumain 3,969 -0,865 4,834 Lysosome MARCH1 Membrane-associated ring finger (C3HC4) 1 -7,194 -5,233 -1,961 MARCH3 Membrane-associated ring finger (C3HC4) 3 -2,272 -1,827 -0,445 MARCH8 Membrane-associated ring finger (C3HC4) 8 -2,028 -1,691 -0,337 NAAA N-acylethanolamine acid amidase -4,962 -4,876 -0,086 NAPSA Napsin A aspartic peptidase -5,740 -5,963 0,223 NEU1 sialidase 1 (lysosomal sialidase) 1,407 1,059 0,348 NPC2 Niemann-Pick disease type C2 1,330 -0,733 2,063 NRAMP1 -5,006 -5,793 0,787 PLBD2 Phospholipase B domain containing 2 3,807 2,943 0,864 PLEKHF1 Pleckstrin homology domain containing, family F member 1 5,907 -0,408 6,315 RAB12 Putative Ras-related protein Rab-12-like -1,423 -1,455 0,031 RAB9A RAB9A, member RAS oncogene family 1,567 1,609 -0,042 RRAGA Ras-related GTP binding A 0,994 0,836 0,158 RRAGD Ras-related GTP-binding protein D-like 6,506 4,300 2,207 SCARB2 Scavenger receptor class B, member 2 -2,586 -4,065 1,479 SMPD1 Sphingomyelin phosphodiesterase 1, acid lysosomal 1,084 0,349 0,735 SRC V-src sarcoma -3,030 -5,799 2,770 STX7 Syntaxin 7 -0,864 0,607 -1,471 TMEM97 Transmembrane protein 97 3,097 2,626 0,471 TPCN2 Two pore segment channel 2 -1,936 -4,003 2,068 UNC13D Unc-13 homolog D 1,307 0,211 1,096 ZC3HAV1 finger, C3HC-type containing 1 0,129 0,376 -0,247

Log2 Fold change Gene Gene discription BLC vs CD20+ BLC vs CD20- CD20- vs CD20+ PSMA6 subunit alpha 6 3,145 1,196 1,948 PSMD9 Proteasome 26S subunit, non-ATPase 9 1,482 0,575 0,907 PSMG2 Proteasome assembly chaperone 2 1,002 0,814 0,188 KIAA0368 Proteasome-associated protein ECM29 1,935 0,323 1,612 C-terminal proteasome-interacting domain of thioredoxin- PITHD1 0,767 0,729 0,038 like domain 1 POMP Proteasome maturation protein 1,126 -0,120 1,245 PSMA1 Proteasome subunit alpha 1 1,140 0,367 0,773 PSMA2 Proteasome subunit alpha 2 0,887 0,490 0,396

PSMA3 Proteasome subunit alpha 3 1,594 0,215 1,379 PSMA4 Proteasome subunit alpha 4 1,105 0,678 0,427 PSMA6 Proteasome subunit alpha 6 1,759 0,951 0,809 PSMB2 Proteasome subunit beta 2 0,966 0,806 0,160 PSMB5 Proteasome subunit beta 5 1,600 0,450 1,150 )proteasome - PSMB7 Proteasome subunit beta 7 1,217 0,667 0,550 PSMC3 Proteasome 26S subunit, ATPase 3 1,064 1,019 0,045 PSMD1 Proteasome 26S subunit, non-ATPase 1 0,906 0,485 0,421 (immuno PSMD11 Proteasome 26S subunit, non-ATPase 11 1,035 0,136 0,898 PSMD14 Proteasome 26S subunit, non-ATPase 14 1,856 0,129 1,727 PSMD3 Proteasome 26S subunit, non-ATPase 3 1,024 0,516 0,508 PSMD7 Proteasome 26S subunit, non-ATPase 7 0,680 0,377 0,303 PSME2 Proteasome activator subunit 2 1,814 1,393 0,421 PSMF1 Proteasome inhibitor subunit 1 1,491 0,415 1,076 PSMG1 Proteasome (prosome, macropain) assembly chaperone 1 1,585 0,358 1,227 PSMG3 Proteasome (prosome, macropain) assembly chaperone 3 1,214 0,870 0,344 SHFM1 26S proteasome complex subunit DSS1 1,440 1,051 0,390 UBR1 protein ligase E3 component n-recognin 1 -0,691 -0,506 -0,185

Log2 Fold change Gene Gene discription BLC vs CD20+ BLC vs CD20- CD20- vs CD20+ CD1B CD1B molecule, T cell surface glycoprotein -6,162 0,154 -6,316 CD1D CD1D molecule, antigen-presenting glycoprotein 1,632 0,241 1,391 CD40 CD40 molecule, TNF receptor superfamily member 5 -1,156 -1,878 0,723 CD70 CD70 molecule, TNF ligand superfamily 7 6,402 0,403 5,999 CD74 CD74 molecule, MHC class II invariant chain -1,961 -0,650 -1,311 CD80 CD80 molecule, T lymphocyte activation antigen 3,882 -1,490 5,372 CD86 CD86 molecule, T lymphocyte activation antigen -3,844 -0,733 -3,111 CIITA Major histocompatibility complex class II transactivator -3,864 -2,685 -1,179 NLRC5 NOD-like receptor family CARD domain containing 5 -3,360 -2,887 -0,473 TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 (OX40L) 5,355 4,477 0,878 Uncharacterized protein, involved in Ag F7G2C5 -1,041 -0,085 -0,956 processing/presentation FCGRT IgG receptor FcRn large subunit p51 -1,816 2,208 -4,023 HFE Hemochromatosis 2,099 1,501 0,598 IFNG Interferon-gamma 2,387 2,578 -0,191 MAMU- Macaca mulatta major histocompatibility comples class II DM -2,833 -0,557 -2,276 DMA alpha MAMU- Macaca mulatta major histocompatibility comples class II DM -2,971 -1,038 -1,933 DMB beta Antigen presentation MAMU- Macaca mulatta major histocompatibility comples class II DO -2,848 -2,050 -0,798 DOA alpha MAMU- Macaca mulatta major histocompatibility comples class II DO -3,981 -1,682 -2,299 DOB beta MAMU- Macaca mulatta major histocompatibility comples class II -2,138 -1,088 -1,050 DQA DQA alpha 1 Major histocompability complex class I polypeptide-related MICB 1,518 0,006 1,512 sequence B MR1 Major histocompatibility complex Class I-Related 5,610 0,255 5,354 PDCD1 Programmed cell death 1 -5,935 0,093 -6,028 RAB27A Ras-related protein Rab-27A 0,958 1,336 -0,377 RAB32 Ras-related protein Rab-32 -3,642 1,781 -5,423 RAB3C Ras-related protein Rab-3C -3,792 -1,595 -2,197