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The Effect of Retrobulbar Irradiation on Exophthalmos, Ductions

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The Effect of Retrobulbar Irradiation on Exophthalmos, Ductions The effect of R. L. J. VAN RUYVEN, W.A. VAN DEN BOSCH, retrobulbar irradiation P.G.H. MULDER, W.M.H. EIJKENBOOM, on exophthalmos, A.D.A. PARIDAENS ductions and soft tissue signs in Graves' ophthalmopathy: a retrospective analysis of 90 cases Abstract Graves' ophthalmopathy affects about 50% of Purpose Retrospective analysis of the effect of dysthyroid patients.1 The disease is characterised retrobulbar irradiation on exophthalmos, ductions and soft tissue signs in patients with by a panorbital inflammation which may lead to Graves' ophthalmopathy. various degrees of exophthalmos, swelling of the Methods We analysed the charts of eyelids and restriction of eye movements. 111 consecutive patients who were treated with Because the disease is assumed to have an retrobulbar irradiation according to autoimmune aetiology, medical treatment aims standardised intake criteria between and 1992 at reducing the inflammatory reaction with After exclusion of patients who underwent 1997. immunosuppressive agents, such as prednisone other treatment (with steroids or orbital or cyclosporine? Unfortunately, such treatment decompression) shortly before or within 6 may be associated with considerable side-effects. months after irradiation, and on whom Retrobulbar irradiation as a means to insufficient data were available, patients were 90 included. For these patients, we analysed the suppress the orbital inflammation was 90 3 exophthalmometry, ductions, soft tissue signs introduced in 1914, and has been widely and visual acuity shortly before irradiation and applied since. The treatment consists of the after 3 and months, respectively. administration of 20 Gy of irradiation 6 R.L.J. van Ruyven Results In the whole group, the Hertel value retrobulbarly in daily fractions of 2 Gy within a 2 W.A. van den Bosch was on average mm (SO both before 4 5 22 2.9) week period. , In the literature, data on the A. D.A. Paridaens irradiation and after 3 and months of follow­ 6 results of retrobulbar irradiation are unclear and Orbital Department up. Separate analysis of data on 25 patients with conflicting. While some authors have reported Rotterdam Eye Hospital bilateral exophthalmos of more than mm also Rotterdam, The Netherlands 24 reduction of proptosis, others found improved revealed no change in exophthalmos at follow­ 11 eye motility or improved soft tissue signS.6- up. In the whole group, both abduction and P.G.H. Mulder In this paper, we present the results of a Department of Medical elevation had improved by about (SO 1° 6.6°; retrospective analysiS of the effect of retrobulbar Biostatistics P = after 3 months. This improvement has 0.05) Erasmus University little clinical significance. In a subgroup of irradiation on exophthalmos, ductions and soft 14 Rotterdam tissue signs in 90 consecutive patients treated patients who showed more than 10° of restricted Rotterdam, The Netherlands eye motility in one or more directions, both according to a standardised treatment protocol. abduction and elevation had increased by about W.M.H. Eijkenboom 4° (SO P = 0.02) at 3 and months follow-up. Department of 10°; 6 Soft tissue signs had improved at months after Methods Radiotherapy 6 irradiation. We found no change in visual acuity University Hospital Dijkzigt We reviewed the charts of 111 consecutive Rotterdam after irradiation. Rotterdam, The Netherlands Conclusion Retrobulbar irradiation in Graves' patients with Graves' ophthalmopathy who were treated with retrobulbar irradiation at our ophthalmopathy does not seem to reduce ADA Paridaens, MD, PhD � exophthalmos. It probably improves eye orbital service between 1992 and 1997. The Rotterdam Eye Hospital motility in patients with severe restrictions. The According to our treatment protocol, Schiedamsevest 180 late improvement in soft tissue signs may either retrobulbar irradiation was performed if the 3011 BH Rotterdam The Netherlands be a late effect of irradiation or be related to the patient had been euthyroid for at least 3 months natural history of the disease. and showed no signs of 'malignant' Graves' e-mail: [email protected] ophthalmopathy (corneal ulceration or Key words Graves' ophthalmopathy, Received: 15 December 1999 presumed optic nerve compression because of a Retrobulbar irradiation Accepted in revised form: diminished visual acuity or abnormal visually 25 February 2000 Eye (2000) 14, 761-764 © 2000 761 Royal College of Ophthalmologists Table 1. Numerical transposition of the NOSPECS classification to Results facilitate the scoring of soft tissue signs The mean Hertel value before radiotherapy was 22 mm Class Description Score (range 13-31 mm, SD 2.8 mm). At both 3 and 6 months 2 Soft tissue involvement follow-up the mean Hertel value remained 22 mm (range 0 None 0 a Minimal 1 14-31 mm, SD 2.8 mm). Separate analysis of the b Moderate 2 ex ophthalmometry of 25 patients with a bilateral Hertel c Marked 3 reading of more than 24 mm shortly before irradiation 3 Exophthalmos also showed no change of their exophthalmos at 0 < 23 mm 0 follow-up. a 23-24 mm The measurements of the ductions showed an b 25-27 mm 2 improvement of both abduction (p = 0.05) and elevation c >27 mm 3 (p = 0.02) of about 1° after 3 months. Virtually no further 4 Extraocular muscle involvement change occurred between 3 and 6 months follow-up 0 None 0 (Fig. 1). a Limitation of motion in extremes of gaze 1 b Evident restriction of motion 2 c Fixation of the globe or globes 3 -- -- 45 r- <7 -'�----��--�----��------� 40 evoked potentials). Furthermore, the symptoms and 37.4 37.2 signs had to have been present for less than 1 year, and 35 IT""f.." f�' I'·' '" I '" the patient had to show at least one symptom or sign within the following NOSPECS classes: moderate or 30 marked soft tissue signs (classes 2b and c), uni- or 25 bilateral exophthalmos of 23 mm or more (classes 3a, b and c) and limitation of eye motility (classes 4a, b and c) 20 (Table 1). Retrobulbar irradiation was performed according to 15 4 the method described by Kriss and Donaldson et al.5 A cumulative dose of 20 Gy was administered to the 10 retrobulbar space in 10 daily fractions of 2 Gy within a period of 2 weeks. 5 For retrospective analysis, patients were excluded in o �____ ______________� __________ � ____ � whom another intervention, such as orbital surgery or o 3 6 immunosuppressive treatment, had been performed within 3 months before or 6 months after irradiation. Using these criteria, 10 patients were excluded because orbital decompression had been performed. Two other 45 �---------------------------------------, patients had been treated with prednisone shortly before radiotherapy, 1 patient was lost to follow-up, and for 8 40 patients some data were lacking. Finally, 90 patients were included: 70 women (78%; mean age 47 years, SD 35 7.1 6.2 6.6 6.0 9.8 years) and 20 men (22%; mean age 40.5 years, SD 9 years). 30 For these 90 patients, the exophthalmos, soft tissue 25 signs, ductions and visual acuity were analysed. The ��I'Ii:' IiA exophthalmos had been assessed with a Hertel 20 -'-- exophthalmometer, the symptoms and signs had been 12 scored according to the NOSPECS classification. To 15 facilitate analysis, we transposed the NOSPECS classification into a numerical system, in which the a, b 10 and c categories were arbitrarily given 1, 2 and 3 points respectively, as depicted in Table 1. The ductions had 5 been measured with a synoptophore in four directions of O�______ Y- ____________Y- ____________T- ____� gaze at our orthoptic department. Normal ductions were o 3 6 defined as an abduction and adduction of more than 40° Fig. 1. Mean abduction (above) and elevation (below) with standard and an elevation and depression of more than 30°. The deviation of all patients. The horizontal axis shows the time in months visual acuity had been measured with a Snellen chart. after radiotherapy. The vertical axis shows duction in degrees. Statistical analysis was performed with the Wilcoxon High-low bars represent the standard deviation. Squares, right eye; paired samples test. triangles, left eye. 762 45 The numerical analysis of the soft tissue signs showed 6.8 7.1 4.9 -� an average score of 1.0 (SD 0.7) before irradiation and of 40 7.2 7.5 0.8 (SD 0.8, P = 0.6) at 3 months thereafter. At 6 months 35 -'-T �3 34.4 after irradiation the average score had improved to 0.6 I· (SD 0.6, P = 0.1). Table 2 summarises the NOSPECS score. 30 29.4 The visual acuity was on average 0.92 both before . "1 I. -'-- irradiation and at follow-up. t W 25 -----L- �'-- 20 Discussion 15 Our data reveal no effect of retrobulbar irradiation on exophthalmos. Even in patients with a large amount of 10 exophthalmos - in whom more effect might theoretically be expected - no reduction in exophthalmos could be 5 detected. A reduction in exophthalmos after irradiation 0 has been described by Petersen et a/. However, their 0 3 6 report was unclear regarding the amount of reduction achievedY Because of the retrospective character of our study, our data must be viewed with caution, since we cannot exclude the possibility that irradiation prevented 45 an increase in exophthalmos. This, however, seems unlikely in view of the reported natural history of the 40 disease. Perros et a/.14 studied the course of ophthalmopathy in a euthyroid group who did not 35 receive any immunosuppressive or surgical treatment. They found a spontaneous decrease in exophthalmos 30 9.4 5.7 8.8 4.7 8.3 after 1-3 months. After irradiation, both elevation and abduction 25 --1- 7.7 improved. However, this average increase of about 1 ° 22.1 20 holds little - if any - clinical significance, in contrast with 18JLI� __ 18.5 .
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