Mt Sinai 112831 Chair Report
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Publicity Waves Based on Manipulated Geoscientific Data Suggesting Climatic Trigger for Majority of Tsunami Findings in the Medi
Zeitschrift für Geomorphologie,Geomorphologie Vol. 58 (2014), Suppl. 3, XXX–XXX Open AccessArticle B Publishedpublished onlineJuly 2014 May 2018 Publicity waves based on manipulated geoscientific data suggesting climatic trigger for majority of tsunami findings in the Mediterranean – Response to ‘Tsunamis in the geological record: Making waves with a cautionary tale from the Mediterranean’ by Marriner et al. (2017) Andreas Vött, Hendrik J. Bruins, Matthijs Gawehn, Beverly N. Goodman-Tchernov, Paolo Marco De Martini, Dieter Kelletat, Giuseppe Mastronuzzi, Klaus Reicherter, Björn R. Röbke, Anja Scheffers, Timo Willershäuser, Pavlos Avramidis, Piero Bellanova, Pedro J.M. Costa, Claudia Finkler, Hanna Hadler, Benjamin Koster, Javier Lario, Eduard Reinhardt, Margret Mathes-Schmidt, Konstantin Ntageretzis, Daniela Pantosti, Ioannis Papanikolaou, Paolo Sansò, Giovanni Scicchitano, Alessandra Smedile, Witek Szczuciński with 3 figures and 3 tables Abstract. This article is a response to the publication by Nick Marriner, David Kaniewski, Christophe Morhange, Clément Flaux, Matthieu Giaime, Matteo Vacchi and James Goff entitled “Tsunamis in the geological record: Making waves with a cautionary tale from the Mediterranean”, published in October 2017 in Science Advances. Making use of radiometric data sets published in the context of selected palaeotsunami studies by independent research groups from different countries, Marriner et al. (2017) carried out statistical and time series analyses. They compared their results with an assessment of Mediterranean storminess since the mid-Holocene that was previously published by Kaniewski et al. (2016) based on a single-core study from coastal Croatia. Marriner et al. (2017) now present “previously unrecognized” 1500-year “tsunami megacycles” which they suggest correlating with Mediterranean climate deterioration. They conclude that up to 90 % of all the ‘tsunamis’ identified in original tsunami papers used for their study are “better as cribed to periods of heightened storminess”. -
Stephanie Wehner – Curriculum Vitae
Stephanie QuTech, Lorentzweg 1 2628 CJ Delft B [email protected] Wehner Born: 8 May 1977 Nationality: German Curriculum Vitae Languages: German, Dutch, English Highlights Science Over 70 publications (> 4800 citations of which > 1100 in 2016, hindex 35, i10- index 62, Google Scholar November 2017) in Science (2x), Nature (1x), Nature Communications (7x), PNAS (1x), IEEE Transactions on Information Theory (7x), CRYPTO (2x), Physical Review Letters (9x, 2x Editor’s suggestion) and others. Works selected for Science’s “Top 10 Breakthroughs of 2015”, Nature’s “Science Events that shaped 2015”, and voted in Top 10 of 2014 in physics news at phys.org. Leadership Co-Founder QCRYPT, now the largest annual international conference on quantum cryptography. Funding ERC Starting Grant 2015 (1.5M EUR), NWO VIDI Grant 2015 (800k EUR). Previous grants in Singapore (resigned) total ≈ 11.4 M EUR (personal share ≈ 1.4M EUR). Collaborative grants Netherlands (19.4M EUR). Press Popular science coverage in New York Times (Front Page), The Economist, TIME, The Times, Huffington Post, New Scientist, Wired, Vice, and others. Outreach Talks at TEDx, New Scientist Live, as well as the Dutch KNAW and others. Perspective article in Science in 2016. Education 11 distinct classes, of which one has received a perfect score on teaching evaluation. edX MOOC Quantum cryptography in fall 2016. Experience Academic appointments 2016-now Antoni van Leeuwenhoek Professor, QuTech, TU Delft, Delft, Netherlands. Roadmap Leader Quantum Internet 2014-2016 Associate Professor, QuTech, TU Delft, Delft, Netherlands. 2013-2014 Associate Professor, School of Computing, National University of Singapore (NUS), Singapore. 2010-2013 Assistant Professor, School of Computing, National University of Singapore, Singapore. -
Scientific Reasoning Competencies: a Case of Preservice Teacher Education
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by University of Dundee Online Publications University of Dundee Scientific Reasoning Competencies Khan, Samia; Krell, Moritz Published in: Canadian Journal of Science, Mathematics and Technology Education DOI: 10.1007/s42330-019-00063-9 Publication date: 2019 Document Version Publisher's PDF, also known as Version of record Link to publication in Discovery Research Portal Citation for published version (APA): Khan, S., & Krell, M. (2019). Scientific Reasoning Competencies: A Case of Preservice Teacher Education. Canadian Journal of Science, Mathematics and Technology Education, 19(4), 446-464. https://doi.org/10.1007/s42330-019-00063-9 General rights Copyright and moral rights for the publications made accessible in Discovery Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from Discovery Research Portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain. • You may freely distribute the URL identifying the publication in the public portal. Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 07. Dec. 2019 Can. J. Sci. Math. Techn. Educ. (2019) 19:446–464 https://doi.org/10.1007/s42330-019-00063-9 Scientific Reasoning Competencies: a Case of Preservice Teacher Education Samia Khan & Moritz Krell Published online: 19 November 2019 # The Author(s) 2019 Abstract In this study, we analysed the scientific reasoning competencies of preservice science teachers from a Canadian sample at the beginning and end of a science teacher education methods course. -
Antibiotics in Cancer Patients: Is the Verdict Still Out?
Editorial Page 1 of 3 Antibiotics in cancer patients: is the verdict still out? ManHee Suh1, Lei Sun2 1Protein Application Institute, SinoBio Scientific Inc., Shanghai 201203, China; 2CytoCares Inc., Shanghai 201203, China Correspondence to: Lei Sun. CytoCares Inc., Shanghai 201203, China. Email: [email protected]. Provenance: This is an invited Editorial commissioned by Section Editor Dr. Ziwei Li (Department of Surgery, The First Hospital Affiliated to Kunming Medical School, Kunming, China). Comment on: Gopalakrishnan V, Spencer CN, Nezi L, et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 2018;359:97-103. Routy B, Le Chatelier E, Derosa L, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 2018;359:91-7. Received: 30 December 2017; Accepted: 10 January 2018; Published: 30 January 2018. doi: 10.21037/amj.2018.01.09 View this article at: http://dx.doi.org/10.21037/amj.2018.01.09 Immune checkpoint inhibitors (ICI) have shown poor immunogenicity of tumor cells (6,7), defective antigen tremendous successes on treatment of multiple tumor presentation during the priming phase (8) and the absence malignancies, offering a valuable but rare commodity of functional tumor-infiltrating lymphocytes (9,10). Tumor to both patients and researchers (1-3). As an important mutational burden (TMB) increases immunogenicity of part of tumor immunotherapies, ICIs inspire the once- tumors and hence has been proposed as a biomarker for questioned idea that although inhibited our immune system response to anti-PD-1 therapy based on an extensive ORR is able to eliminate tumor cells in a similar way that it analysis by a John Hopkins team from an extensive literature does to infectious microorganisms. -
The Long Road to a Universal Influenza Virus Vaccine †
Abstract The Long Road to a Universal Influenza Virus Vaccine † Peter Palese Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; [email protected] † Viruses 2020 - Novel Concepts in Virology, Barcelona, Spain, 5–7 February 2020. Published: 8 July 2020 Abstract: Seasonal and pandemic influenza virus infections can cause significant disease worldwide. Current vaccines only provide limited, short-lived protection, and antigenic drift/shift in the hemagglutinin (HA) surface glycoprotein necessitates their annual reformulation and re-administration. To overcome these limitations, universal influenza virus vaccine strategies aim at eliciting broadly protective antibodies to conserved epitopes of the HA. We have developed two approaches. (1) The first is based on “chimeric” HA constructs that retain the conserved stalk domain of the HA and have exotic HA heads. Vaccination and boosting with such constructs successfully redirects the immune system in animals and in humans towards the conserved immune sub-dominant domains of the HA stalks; this results in an antigenic silencing of the HA heads and a protective immune response facilitated by the conserved HA stalks. In mice and ferrets, such a strategy protects the animals against homo-subtypic and hetero-subtypic challenge with influenza A strains as well as against influenza B variants. It is hoped that vaccine constructs expressing three components (i.e., conserved group 1 HA stalks, conserved group 2 HA stalks, and conserved influenza B HA stalks) will be protective against all future seasonal and pandemic strains. (2) The “mosaic” HA approach is based on antigenic silencing of the major immunodominant antigenic sites of the HA heads by only replacing those epitopes with corresponding sequences of exotic avian HAs, yielding “mosaic” HAs. -
Toward a Universal Influenza Virus (Revised)
TOWARDS A UNIVERSAL INFLUENZA VIRUS VACCINE Peter Palese Icahn School of Medicine at Mount Sinai New York OPTIONS IX 8-26-16 ISIRV - Options IX for the Control of Influenza Peter Palese, PhD Professor and Chair Department of Microbiology Icahn School of Medicine, New York Mount Sinai has submitted patent applications for a universal influenza virus vaccine Work has been supported by the NIH, The Bill & Melinda Gates Foundation, GSK My presentation does not include discussion of off-label or investigational use. Similar variation for influenza, HIV and HCV F. Krammer EIGHTEEN SUBTYPES OF INFLUENZA A VIRUS HEMAGGLUTININS Group 2 Influenza A Influenza B Group 1 bat HAs Influenza viruses circulating in the human population B pH1N1 H3N2 (Group2) A ? H2N2 (Group1) H1N1 (Group1) 1918 1940 1960 1980 2000 AVIAN INFLUENZA VIRUSES INFECTING HUMANS H5N6 China 2016 H7N9 China 2015, 2014, 2013 H10N8 China 2013 H6N1 Taiwan 2013 H10N7 Australia,Egypt 2010,2004 H7N3 Mexico,UK,Canada,Italy 2012,2006,04,03 H7N2 UK,USA 2007,2003 H9N2 Hong Kong 1999 H5N1 Asia,Europe,Africa, Hong Kong 2015-2003 , 1997 H7N7 Netherlands,UK,USA,Austr.,USA 2003,96,80,77,59 INFLUENZA VIRUS VACCINES INACTIVATED LIFE ATTENUATED RECOMBINANT INFLUENZA VIRUS VACCINE STRAINS 2016-2017 A/California/7/2009 (H1N1)pdm09 A/Hong Kong/4801/2014 (H3N2) B/Phuket/3073/2013 B/Brisbane/60/2008 • INFLUENZA VIRUS VACCINES ARE UNIQUE. • THEY HAVE TO BE GIVEN ANNUALLY, BECAUSE NOVEL VACCINE FORMULATIONS HAVE TO BE PREPARED REFLECTING THE RAPID ANTIGENIC CHANGE OF THE VIRUS. Antigenic diversity: analysis -
Sequence of the 1918 Pandemic Influenza Virus Nonstructural Gene (NS) Segment and Characterization of Recombinant Viruses Bearing the 1918 NS Genes
Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes Christopher F. Basler*†, Ann H. Reid*‡, Jody K. Dybing*§¶, Thomas A. Janczewski‡, Thomas G. Fanning‡, Hongyong Zheng†, Mirella Salvatore†, Michael L. Perdue§ʈ**, David E. Swayne§, Adolfo Garcı´a-Sastre†ʈ, Peter Palese†ʈ, and Jeffery K. Taubenberger‡ʈ †Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029; ‡Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306; and §Southeast Poultry Research Laboratory, United States Department of Agriculture, Athens, GA 30605 Contributed by Peter Palese, December 5, 2000 The influenza A virus pandemic of 1918–1919 resulted in an generation of influenza viruses from cloned cDNAs allow re- estimated 20–40 million deaths worldwide. The hemagglutinin combinant influenza viruses bearing genes of the 1918 pandemic and neuraminidase sequences of the 1918 virus were previously virus to be constructed. The resulting viruses can be studied in determined. We here report the sequence of the A͞Brevig Mission͞ vitro or in animal models (12, 13). 1͞18 (H1N1) virus nonstructural (NS) segment encoding two pro- The full-length sequences of the two predominant surface teins, NS1 and nuclear export protein. Phylogenetically, these proteins of the 1918 virus, hemagglutinin (HA) and neuramin- genes appear to be close to the common ancestor of subsequent idase (NA), have recently been described (2, 9). These sequences human and classical swine strain NS genes. Recently, the influenza were determined first because influenza pandemics are thought A virus NS1 protein was shown to be a type I IFN antagonist that to result from the emergence of influenza virus strains with novel plays an important role in viral pathogenesis. -
SKA-Athena Synergy White Paper
SKA-Athena Synergy White Paper SKA-Athena Synergy Team July 2018. Edited by: Francisco J. Carrera and Silvia Martínez-Núñez on behalf of the Athena Community Office. Revisions provided by: Judith Croston, Andrew C. Fabian, Robert Laing, Didier Barret, Robert Braun, Kirpal Nandra Authorship Authors Rossella Cassano (INAF-Istituto di Radioastronomia, Italy). • Rob Fender (University of Oxford, United Kingdom). • Chiara Ferrari (Observatoire de la Côte d’Azur, France). • Andrea Merloni (Max-Planck Institute for Extraterrestrial Physics, Germany). • Contributors Takuya Akahori (Kagoshima University, Japan). • Hiroki Akamatsu (SRON Netherlands Institute for Space Research, The Netherlands). • Yago Ascasibar (Universidad Autónoma de Madrid, Spain). • David Ballantyne (Georgia Institute of Technology, United States). • Gianfranco Brunetti (INAF-Istituto di Radioastronomia, Italy) and Maxim Markevitch (NASA-Goddard • Space Flight Center, United States). Judith Croston (The Open University, United Kingdom). • Imma Donnarumma (Agenzia Spaziale Italiana, Italy) and E. M. Rossi (Leiden Observatory, The • Netherlands). Robert Ferdman (University of East Anglia, United Kingdom) on behalf of the SKA Pulsar Science • Working Group. Luigina Feretti (INAF-Istituto di Radioastronomia, Italy) and Federica Govoni (INAF Osservatorio • Astronomico,Italy). Jan Forbrich (University of Hertfordshire, United Kingdom). • Giancarlo Ghirlanda (INAF-Osservatorio Astronomico di Brera and University Milano Bicocca, Italy). • Adriano Ingallinera (INAF-Osservatorio Astrofisico di Catania, Italy). • Andrei Mesinger (Scuola Normale Superiore, Italy). • Vanessa Moss and Elaine Sadler (Sydney Institute for Astronomy/CAASTRO and University of Sydney, • Australia). Fabrizio Nicastro (Osservatorio Astronomico di Roma,Italy), Edvige Corbelli (INAF-Osservatorio As- • trofisico di Arcetri, Italy) and Luigi Piro (INAF, Istituto di Astrofisica e Planetologia Spaziali, Italy). Paolo Padovani (European Southern Observatory, Germany). • Francesca Panessa (INAF/Istituto di Astrofisica e Planetologia Spaziali, Italy). -
Comparison of Turkish Elementary School Science Curriculum: 2005- 2013-2017
Comparison of Turkish Elementary School rch Article rch Science Curriculum: 2005-2013-2017 Resea Cihad ŞENTÜRK1 Mevlüt AYDOĞMUŞ 2 Abstract: Change is an inevitable reality of life. The developments in the world affect the International Journal of qualities expected from individuals and this reflects on the educational systems. For Modern Education Studies this reason, the high competitiveness of the countries in the international arena requires that the education systems comply with the requirements of the age. In December, 2017 Turkey, it is seen that the curriculum has been changed in various times since the Volume 1, No 1 announcement of the Republic. In 2005, a major change was done and the curriculum Pages: 46-57 was prepared in line with the philosophical and structural approach as well as the the http://www.ijonmes.net requirements of the age. These programs were updated in 2013 by reviewing the 4 + 4 + 4 education system which was designed in 2012. In 2017, the curriculum has been updated with stakeholder’s feedback in line with the problems faced by previously developed programs and practices. In this context, the aim of the study is to compare the elementary school science curriculums which were prepared based on the constructivist approach in 2005, updated in 2013 and re-revised in 2017, and to reveal their similarities and differences. In the study, the elementary school science curriculums (2005-2013-2017) were compared by investigating in terms of basic philosophy of the curriculum, the general aims of the curriculum, key competences in the curriculum, and the approaches during the teaching situations, the evaluation process, the subject areas, the achievements and the course hours. -
Scienti C Globalism During a Global Crisis:Research Collaboration and Open Access Publications on COVID-19
Scientic Globalism During A Global Crisis:Research Collaboration and Open Access Publications on COVID-19 Jenny J. Lee ( [email protected] ) University of Arizona https://orcid.org/0000-0003-2799-487X John P. Haupt University of Arizona Keywords: Global Science, International Research Collaboration, COVID-19 Posted Date: June 9th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-33977/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/11 Abstract This study sought to understand the nature of scientic globalism during a global crisis, particularly COVID-19. Findings show that scientic globalism can be observed differently during COVID-19 than pre-COVID-19. Despite the tense geopolitical climate, countries increased their proportion of international collaboration and open access publications during the pandemic. However, not all countries engaged more globally. Countries that have been more impacted by the crisis and those with relatively lower GDPs tended to participate more in scientic globalism than their counterparts. Introduction COVID-19 is undoubtedly the most pressing topic in global science research today. While scientists in every major region of the world are scrambling to understand and halt the virus’ spread, national tensions are increasing. Accusations about what country is to blame, what country is hoarding medical supplies, and what country will develop the vaccine, and the extent it will be shared, have fueled international tensions. Governmental warnings about the stealing of COVID-19 research data (National Cyber Security Centre, 2020) and accusations about the intentional spread of misinformation by some countries (Moore, 2020) has made international cooperation more challenging than in the past. -
Antigenic Sites in Influenza H1 Hemagglutinin Display Species- Specific Immunodominance
Antigenic sites in influenza H1 hemagglutinin display species- specific immunodominance Sean T.H. Liu, … , Florian Krammer, Peter Palese J Clin Invest. 2018. https://doi.org/10.1172/JCI122895. Concise Communication In-Press Preview Immunology Virology Hemagglutination inhibition (HI) titers are a major correlate of protection for influenza-related illness. The influenza virus hemagglutinin possesses antigenic sites that are the targets of HI active antibodies. Here, a panel of mutant viruses each lacking a classically defined antigenic site was created to compare the species-specific immunodominance of the antigenic sites in a clinically relevant hemagglutinin. HI active antibodies of antisera from influenza-virus infected mice targeted sites Sb and Ca2. HI active antibodies of guinea pigs were not directed against any specific antigenic site, although trends were observed towards Sb, Ca2, and Sa. HI titers of antisera from infected ferrets were significantly affected by site Sa. HI active antibodies of adult humans followed yet another immunodominance pattern, where sites Sb and Sa were immunodominant. When comparing the HI profiles between different species by antigenic cartography, animals and humans grouped separately. This study provides characterizations of the antibody-mediated immune responses against the head domain of a recent H1 hemagglutinin in animals and humans. Find the latest version: https://jci.me/122895/pdf 1 Title 2 Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance 3 4 Sean T. H. Liu1,2, Mohammad Amin Behzadi1, †, Weina Sun1, †, Alec Freyn1, Wen-Chun Liu1, Felix Broecker1, 5 Randy A. Albrecht1,3, Nicole M. Bouvier1,2, Viviana Simon1,3, Raffael Nachbagauer1, Florian Krammer1, and 6 Peter Palese1 7 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. -
Adolfo García-Sastre Professor, Department of Microbiology
Adolfo García-Sastre Professor, Department of Microbiology Fishberg Professor, Department of Medicine, Division of Infectious Diseases Director, Global Health and Emerging Pathogens Institute Icahn School of Medicine at Mount Sinai 1468 Madison Avenue, New York, NY 10029 [email protected]; Short Bio; Dr. Adolfo García-Sastre is Professor in the Departments of Microbiology and Medicine and Director of the Global Health and Emerging Pathogens Institute of Icahn School of Medicine at Mount Sinai in New York. He received his BSc and PhD from University of Salamanca, Spain and postdoctoral training at the Laboratory of Peter Palese at Mount Sinai School of medicine in New York City. Area of Research; For the past 30 years, his research interest has been focused on the molecular biology of influenza viruses and several other negative strand RNA viruses. During his post-doctoral training in the early 1990s, he developed, for the first time, novel strategies for expression of foreign antigens by a negative strand RNA virus, influenza virus. He has made major contributions to the influenza virus field, including 1) the development of reverse genetics techniques allowing the generation of recombinant influenza viruses from plasmid DNA, (studies in collaboration with Dr. Palese); 2) the generation and evaluation of negative strand RNA virus vectors as potential vaccine candidates against different infectious diseases, including malaria and AIDS, and 3) the identification of the biological role of the non structural protein NS1 of influenza virus during infection: the inhibition of the type I interferon (IFN) system. His studies provided the first description and molecular analysis of a viral- encoded IFN antagonist among negative strand RNA viruses.