JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity Amendola, Pier Giorgio; Zaghet, Nico; Ramalho, João J; Johansen, Jens Vilstrup; Boxem, Mike; Salcini, Anna Elisabetta Published in: P L o S Genetics DOI: 10.1371/journal.pgen.1006632 Publication date: 2017 Document version Publisher's PDF, also known as Version of record Document license: CC BY Citation for published version (APA): Amendola, P. G., Zaghet, N., Ramalho, J. J., Johansen, J. V., Boxem, M., & Salcini, A. E. (2017). JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity. P L o S Genetics, 13(2), [e1006632]. https://doi.org/10.1371/journal.pgen.1006632 Download date: 29. sep.. 2021 RESEARCH ARTICLE JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity Pier Giorgio Amendola1,2, Nico Zaghet1,2, João J. Ramalho3, Jens Vilstrup Johansen1,2, Mike Boxem3, Anna Elisabetta Salcini1,2* 1 Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark, 2 Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark, 3 Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, CH Utrecht, The Netherlands a1111111111 a1111111111 *
[email protected] a1111111111 a1111111111 a1111111111 Abstract The eukaryotic genome is organized in a three-dimensional structure called chromatin, con- stituted by DNA and associated proteins, the majority of which are histones. Post-transla- OPEN ACCESS tional modifications of histone proteins greatly influence chromatin structure and regulate Citation: Amendola PG, Zaghet N, Ramalho JJ, many DNA-based biological processes.