VRX Circulatory System Support

Supports Healthy Function

60 Capsules

INGREDIENT S: Horse Chestnut , Witch-Hazel and Ginkgo Biloba

PRINCIPAL FUNCTIONS

Fights varicose , and varicose ulcers, prevents phlebitis,phlebitis, , swelling and bruising. Exerts venotonic, antantii -inflammatory effects, also an aid to wounds, intertrigo, , stretch marks,marks, burns and cerviccervicitis.itis. Combats cellulite, venous , cracked skin, improvesimproves blood flow,flow, increases resistance, fights chronic venous insufficiinsufficiency,ency, reduces itching, burning, pain from and reducesreduces of the llegs.egs.

FORMULATION AND BENEFITS OF ACTIVE INGREDIENTS

HORSE CHESTNUT (Aesculus hippocastanum L )

General

Horse chestnut originally comes from Northern India, Asia Minor and the Caucasus (a mountinous region dividing Europe and Asia). This tree grows to between 15-20m high, bearing its fruit which is a green, softly spiky capsule containing one nut-like seed called horse- chestnuts. It blooms from early spring to midsummer. The seed extract of horse chestnut is widely used in Europe to treat chronic venous insufficiency, a syndrome that includes leg swelling, varicose veins, leg pain, itching and skin sores. This extract is recommended for a variety of medical conditions and THERE IS STRONG SCIENTIFIC EVIDENCE IN SUPPORT OF HORSE CHESNUT USE FOR CHRONIC VENOUS INSUFFICIENCY.

BIOCHEMICAL COMPOSITION AND MECHANISM OF ACTION

Its main components include: Aescin (Reduces inflammation and edema formation) catechins, allantoin, capsulaescic acids, telaescin, fraxin, quercetin, saponins, aesculine, tannins, acetic acid, angelic acid, glucuronic acid and citric acid. Horse Chestnut is one of the best remedies used for toning the and , because of its composition of Aescin and Aesculine, as these ingredients have the ability of preventing edema formation and increasing resistance of the blood vessels.

CHRONIC VENOUS INSUFFICIENCY

Chronic venous insufficiency is a condition that has been diagnosed more frequently in Europe which includes the symptoms of swollen legs, varicose veins, leg pain, itching (pruritis) and skin sores. Laboratory research in animals and humans have shown that the seed extract of horse chestnut benefits patients with the condition. STUDIES HAVE REPORTED REDUCTIONS IN LEG INFLAMMATION, PAIN, ITCHING AND FATIGUE. There is even evidence suggesting they are as effective as .

BENEFICIAL USES:

Useful in Chronic Venous Insufficiency Reduces leg swelling Fights Itching and pain from Varicose Veins Reduces leg cramps and Sores Reduces Inflammation Helps prevent prostate hypertrophy and hemorrhoids Useful against Bladder Disorders Assists in incontinence and cystitis Useful for Pulmonary Edema (Oedema) Helpful for Gallbladder Disease Useful in the prevention of Pulmonary

SIDE EFFECTS

People with an allergy to horse chestnut, should use extreme caution in its use, patients with diabetes, should consult their doctor.

WITCH-HAZEL (Hamamelis virginiana )

General

Witch-Hazel is a shrub native to North America, especially Nebraska, Virginia, Minnesota, Texas and Florida, where it grows in wet or waterlogged forests in temperate zones. Formerly used by the Indians, it was introduced to Europe in the late 1800`s. Witch-Hazel leaves contain ASTRINGENT, VASOCONSTRICTOR, HEMOSTATIC, VITAMIN AND ANTIMICROBIAL properties. This plant is used mainly in venous circulation disorders, such as varicose veins, hemorrhoids, phlebitis, menopausal disorders. When used externally it is used as an astringent and wound healer, especially for certain types of dermatitis, skin irritations, sprains and bruises. It is also a plant commonly used in homeopathy, forming part of many remedies for both external and internal usage.

Scientific classification

Kingdom: Plantae Division: Magnoliophyta Class: Magnoliopsida Order: Saxifragales Family: Hamamelidaceae Genus: Hamamelis Species: H. virginiana

BIOCHEMICAL COMPOSITION AND MECHANISMS OF ACTION

The leaves contain a high proportion of tannins, gallic and caffeic acid and several flavone glycosides including quercetin, myricetin and kaempferol. It is also particularly rich in essential oils. THE CHEMICAL COMPOSITION OF THE BARK IS QUITE SIMILAR TO THAT OF THE LEAVES. ITS TANNINS AND OTHER ACIDS, FUNCTION AS ANTIOXIDANTS, PROVIDING PROTECTION AGAINST CELLULAR DAMAGE AND THE PREVENTION OF PREMATURE AGING.

It has ASTRINGENT, VASOCONSTRICTOR, REFRESHING, HAEMOSTATIC, VITAMIN, ANTIMICROBIAL AND DECONGESTANT PROPERTIES. It helps to inhibit perspiration and attenuates inflammation of the extremities. Helps improve venous circulation, especially in pelvic venous congestion syndrome, hemorrhoids, varicose veins and phlebitis. IMPROVES THE RESISTANCE OF SMALL BLOOD VESSELS and prevents breakage.

The distilled extract is used as a skin tonic for CALMING AND COOLING, PAINFUL SWELLING, DISINFECTION OF WOUNDS, IRRITATED SKIN RESULTING FROM SKIN CONGESTION, AN ASTRINGENT, HELPS HEAL POORLY HEALED WOUNDS AND FOR CERTAIN TYPES OF DERMATITIS. Also used in compresses, to treat bruises, swelling, sprains, pimples, and is widely used in menopausal disorders.

ASTRINGENT: Works as an astringent to remove excess in the skin, while closing irritated pores.

BENEFICIAL USES:

Useful for Phlebitis

Assists Blood Circulation

Astringent

Strengthens Blood Vessels Enhancing Circulation

Attenuates Vein Inflammation

Improves Blood Vessel Resistance

Eliminates fat content in the skin

Haemostatic

Helpful for Hemorrhoids and lessens the discomfort of varicose veins

Reduces Pain

Antidiarrheal

Antimicrobial

CONTRAINDICATIONS

No contraindications found in regard to contact with the skin, however, individuals sensitive to witch- hazel should use extreme caution.

GINKGO BILOBA (Ginkgo biloba )

General

Ginkgo Biloba has been used medicinally for thousands of years and is a unique species of tree with no close living relatives, with some specimens being claimed to be more than 1,000 years old. Originally from China, it is now cultivated worldwide. Ginkgo is used for the treatment of numerous conditions, backed up by scientific research, as a MEMORY AND CONCENTRATION ENHANCER, FOR DECREASING FATIGUE, DEPRESSION, ANXIETY, BLOCKAGES OF MANY OF THE EFFECTS OF PLATELET-ACTIVATING FACTOR (PLATELET AGGREGATION, BLOOD CLOTTING), THEREBY REDUCING THE RISK OF DEVELOPING THROMBOSIS.

There is EVIDENCE DEMONSTRATING GINKGO'S EFFICACY IN THE TREATMENT OF INTERMITTENT , ALZHEIMER'S, MULTI-INFARCT DEMENTIA, AS WELL AS " CEREBROVASCULAR INSUFFICIENCY" (a syndrome thought to be secondary to atherosclerotic disease, characterized by insufficient blood flow to the brain resulting in impaired concentration, confusion, decreased performance physical fatigue, headache, dizziness, depression and anxiety). It is equally useful for symptoms of Premenstrual Syndrome and vascular lesion reduction, induced by . A recent extensive study has now changed the evidence against the use of ginkgo for tinnitus.

Scientific classification

Kingdom: Plantae Division: Ginkgophyta Class: Ginkgoopsida Order: Ginkgoales Family: Ginkgoaceae Gender: Ginkgo Species: G. biloba

BIOCHEMICAL COMPOSITION AND MECHANISMS OF ACTION

The compounds that have pharmacological activity; terpene lactones, polyphenols and flavonoids exert ANTIPLATELET action, which reduces the tendency of platelets to clump together, so it reduces the formation of clots in veins and arteries. A very useful aid, if used as part of the recovery process from stroke and heart attack . It is an excellent cerebral oxygenator, due to its use of glucose in the production of Adenosine Triphosphate (ATP).

EFFECT OF FLAVONOIDS: The flavonoids in Ginkgo Biloba work by neutralizing free radicals, thus slowing down the aging process.

VENOUS CLAUDICATION characterized by (pain in the legs caused by atherosclerotic blockages more proximal to the affected area). Several studies indicate that Ginkgo biloba taken orally can produce improvements in symptoms from claudication (painful, aching, cramping, or tired feeling in the legs that occurs during walking due to blockages in the arteries).

DEMENTIA: multi-infarct dementia and alzheimer's. Scientific literature indicates that ginkgo benefits people with dementia at the initial stages of Alzheimer's disease and multi- infarct dementia and can be as helpful as acetylcholinesterase inhibitor drugs such as donepezil (Aricept ®).

CEREBROVASCULAR INSUFFICIENCY: Several clinical trials have evaluated ginkgo as a treatment of "cerebrovascular insufficiency" This condition includes symptoms such as impaired concentration, confusion, decreased performance physical fatigue, headache, dizziness, depression and anxiety. It is believed that cerebral insufficiency is a result of decreased blood flow to the brain due to blockages within the blood vessels. The research reports on the benefits of ginkgo in patients with these symptoms.

BENEFICIAL USES:

Useful as a Treatment for Chronic Venous Insufficiency Varicose Veins

Excellent for Hemorrhoids and Improvement of the Cardiovascular System

Anti-inflammatory

Helps Prevent

Assists in Asthma

Improves Blood Flow

Powerful Antioxidant

Helps Prevent Memory Impairment Associated with Aging Reduces the Side Effects of Chemotherapy

Enhances Cognitive Performance

Assists in Depressive Problems in Diabetics

Assists in Neuropathy; a disorder that occurs when nerves in the peripheral nervous system are damaged.

Useful for Gastric Cancer

Helpful for Multiple Sclerosis

Relieves Symptoms of Premenstrual Syndrome

Useful for Diabetic Retinopathy

Assists in Sexual Dysfunction

Helpful in cases of Stroke

Counteracts Vitiligo progression

SIDE EFFECTS:

People allergic to Ginkgo Biloba components, should use caution. In general, Ginkgo Biloba Extract use in healthy people has not given rise to any reports of discomfort. People with blood clotting problems, should consult with their doctor before use.

NBN Living

The best way of living / Tu mejor modo de vivir

vrx

HERBAL SUPPLEMENT

Witch-Hazel, Horse Chestnut, Ginkgo Biloba

60 Capsules

Directions/Instrucciones para su consumo:

As a dietary supplement, take one capsule in the morning and one at night orally with liquid / Como un suplemento alimenticio, tomar una cápsula por la mañana y otra por la noche por vía oral con líquido.

Supplement Facts / Datos del Suplemento

Serving Size / Tamaño de la Porción: 2 capsules / cápsulas

Servings per Container / Porciones por Envase: 30

Amount per Serving/Cantidad por Porción: %DV**/ %VD**

Witch-Hazel (bark) (Hamamelis virginiana ) 400 mg †

Horse Chestnut / Castaño de Indias 200 mg † (Aesculus hippocastanum ) (Seed Extract)

Ginkgo Biloba Root 200 mg †

† Daily Value (DV) not established / Valor Diario (VD) no establecido. **Percent Daily Values (%DV) are based on a 2,000 calorie diet / Porcentaje de Valores Diarios (%VD) se basa en una dieta de 2,000 calorías diarias.

Other Ingredients:

Gelatin (capsule) / Gelatina (cápsula), Rice Flour / Harina de Arroz, Corn Starch / Almidón de Maiz, Silicon Dioxide / Dióxido de Silicio, Magnesium Stearate / Estearato de Magnesio.

REFERENCES

1. Bassler D, Okpanyi S, Schrodter A, et al. Bioavailability of beta-aescin from horse chestnut seed extract: comparative clinical studies of two Galenic formulations. Adv Ther 2003 SepOct;20(5):295-304. 2. Bielanski TE, Piotrowski ZH. Horse-chestnut seed extract for chronic venous insufficiency. J Fam Pract 1999 Mar;48(3):171-2. 3. Birks J, Grimley Evans J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2007 Apr 18;(2):CD003120. 4. Carlson JJ, Farquhar JW, DiNucci E, et al. Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. J Am Diet Assoc 2007 Mar;107(3):422-32. 5. Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980 Jan;6(2):150-1. 6. Diehm C, Trampisch HJ, Lange S, et al. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet 2- 3-1996;347(8997):292-294. 7. Diehm C, Vollbrecht D, Amendt K, et al. Medical edema protection--clinical benefit in patients with chronic deep vein incompetence. A placebo controlled double blind study. Vasa 1992;21(2):188-192. 8. Ernst E, Pittler MH, Stevinson C. Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments. Am J Clin Dermatol 2002;3(5):341-8. 9. Facultad de lenguas y culturas, Universidad de Kyushu, Japón (en inglés) 10. Ginkgo biloba. Royal Botanic Gardens, Kew: World Checklist of Selected Plant Families. Consultado el 20 de marzo de 2010. 11. Hilton M, Stuart E. Ginkgo biloba for tinnitus. Cochrane Database Syst Rev 2004;(2):CD003852. 12. Issing W, Klein P, Weiser M. The homeopathic preparation Vertigoheel versus Ginkgo biloba in the treatment of vertigo in an elderly population: a double-blinded, randomized, controlled clinical trial. J Altern Complement Med 2005;11(1):155-160. 13. Kampman K, Majewska MD, Tourian K, et al. A pilot trial of piracetam and ginkgo biloba for the treatment of cocaine dependence. Addict Behav 2003;28(3):437-448. 14. Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res 2002;16 Suppl 1:S1-5. 15. Kohler S, Funk P, Kieser M. Influence of a 7-day treatment with Ginkgo biloba special extract EGb 761 on bleeding time and coagulation: a randomized, placebo-controlled, double-blind study in healthy volunteers. Blood Coagul Fibrinolysis 2004;15(4):303-309.

16. Lange S, Freitag G, Trampisch HJ. Practical experience with the design and analysis of a three-armed equivalence study. Eur J Clin Pharmacol. 1998 Sep;54(7):535-40. 17. Lovera J, Bagert B, Smoot K, et al. Ginkgo biloba for the improvement of cognitive performance in multiple sclerosis: a randomized, placebo-controlled trial. Mult Scler 2007 Apr;13(3):376-85. 18. Martín, Diana. (2001). Ginkgo Biloba. "Colección Farmacia natural". Madrid: Editorial Edaf. ISBN 84-414-0925-0 e ISBN 978-84-414-0925-5. 19. Mazza M, Capuano A, Bria P, et al. Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study. Eur J Neurol 2006 Sep;13(9):981-5. 20. Napryeyenko O, Borzenko I; GINDEM-NP Study Group. Ginkgo biloba special extract in dementia with neuropsychiatric features. A randomised, placebo-controlled, double-blind clinical trial. Arzneimittelforschung 2007;57(1):4-11. 21. Ottillinger B, Greeske K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC Cardiovasc Disord 2001;1(1):5. 22. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev 2006 Jan 25;(1):CD003230. 23. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992 Aug;47(4 Pt 2):380-3. 24. Pros Casas, Miguel. (2000). Salud para el cuerpo y la mente con el ginkgo biloba. "Colección La naturaleza cura". Barcelona: Editorial Océano. ISBN 84-494-1667-1 e ISBN 978-84-494-1667-5. 25. Rehn D, Unkauf M, Klein P, et al. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487. 26. Robertson SM, Davey RT, Voell J, et al. Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects. Curr Med Res Opin 2008 Feb;24(2):591-9. 27. Siebert U, Brach M, Sroczynski G, et al. Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta- analysis of randomized controlled trials and large observational studies. Int Angiol 2002;21(4):305-315. 28. Steven T. DeKosky, MD; Jeff D. Williamson, et al, Ginkgo biloba for Prevention of Dementia. A Randomized Controlled Trial JAMA. 2008;300(19):2253-2262. 29. Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. Adv Ther 2006 Jan- Feb;23(1):179-90. 30. Thomas M, Sheran J, Smith N, et al. AKL1, a botanical mixture for the treatment of asthma: a randomised, double-blind, placebo-controlled, cross-over study. BMC Pulm Med. 2007 Mar 20;7:4.

31. Van Dongen M, van Rossum E, Kessels A, et al. Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial. J Clin Epidemiol 2003;56(4):367-376.

32. Vayssairat M, Debure C, Maurel A, et al. Horse-chestnut seed extract for chronic venous insufficiency. Lancet 4-27-1996;347(9009):1182. 33. Wang J, Zhou S, Bronks R, et al. Supervised exercise training combined with ginkgo biloba treatment for patients with peripheral arterial disease. Clin Rehabil 2007 Jul;21(7):579-86. 34. Wolf HR. Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily? Drugs R D 2006;7(3):163-72. 35. Zeng X, Liu M, Yang Y, et al. Ginkgo biloba for acute ischaemic stroke. Cochrane Database Syst Rev 2005 Oct 19;(4):CD003691.