heterodontus underlay baboon mouse rat 1 20k 40k 60k

Evx2

80k HoxD13 HoxD12 HoxD11 100k

HoxD10

120k HoxD8

140k HoxD4

160k HoxD3 175667 HoxD1 100% baboon 50% mouse

rat heterodontus

0k 2k 4k 6k 8k 10k 12k 14k 16k 18k 20k

baboon

mouse

rat heterodontus

20k 22k 24k 26k 28k 30k 32k 34k 36k 38k 40k

baboon

mouse

rat heterodontus

40k 42k 44k 46k 48k 50k 52k 54k 56k 58k 60k

Evx2 HoxD13 3 2 1 1 2

baboon

mouse

rat heterodontus

60k 62k 64k 66k 68k 70k 72k 74k 76k 78k 80k HoxD12 HoxD11 1 2 1 2

100% baboon 50% mouse

rat heterodontus

80k 82k 84k 86k 88k 90k 92k 94k 96k 98k 100k

HoxD10 HoxD9 HoxD8 1 2 1 2 1 2

baboon

mouse

rat heterodontus

100k 102k 104k 106k 108k 110k 112k 114k 116k 118k 120k

HoxD4 1 2

baboon

mouse

rat heterodontus

120k 122k 124k 126k 128k 130k 132k 134k 136k 138k 140k HoxD3 1 2

100% baboon 50% mouse

rat heterodontus

140k 142k 144k 146k 148k 150k 152k 154k 156k 158k 160k

HoxD1 1 2

baboon

mouse

rat heterodontus

160k 162k 164k 166k 168k 170k 172k 174k 175667 •64096 67765 (0; LocusLink) ☞ •76904 78719 (0; LocusLink) ☞ •82370 82596 (0; Regulatory) Genetic analysis of a Hoxd-12 regulatory element reveals global ver- sus local modes of controls in the HoxD complex. Herault Y,Beck- ers J, Kondo T,Fraudeau N, Duboule D. Development. 1998 May;125(9):1669-77. ☞ full text ☞ •83791 84749 (0; LocusLink) ☞ •88252 88478 (0; Regulatory) Transgenic analysis of a potential Hoxd-11 limb regulatory element present in tetrapods and fish. Beckers J, Gerard M, Duboule D. Dev Biol. 1996 Dec 15;180(2):543-53. ☞ full text ☞ •90836 91017 (0; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ •91142 91286 (0; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ •91345 92060 (1; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ •91345 93131 (0; LocusLink) ☞ •92210 92342 (1; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ •92896 93131 (1; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ •93311 93400 (0; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ •93481 93657 (0; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ •94266 94413 (1; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ •94396 94686 (0; Regulatory) corresponds to mouse element. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. Gerard M, Duboule D, ZakanyJ.EMBO J. 1993 Sep;12(9):3539-50. ☞ in vivo targeted mutagenesis of a regulatory element required for po- sitioning the Hoxd-11 and Hoxd-10 expression boundaries. Gerard M, Chen JY,Gronemeyer H, Chambon P,Duboule D, ZakanyJ. Dev1996 Sep 15;10(18):2326-34. ☞ •100823 103220 (0; LocusLink) ☞ •104221 104808 (0; Regulatory) corresponds to mouse element. Comparison of mouse and human HOX-4 complexesdefines conserved sequences involved in the regu- lation of Hox-4.4. Renucci A, Zappavigna V,ZakanyJ,Izpisua-Bel- monte JC, Burki K, Duboule D. EMBO J. 1992 Apr;11(4):1459-68. ☞ •105348 105666 (0; Regulatory) corresponds to mouse element. Comparison of mouse and human HOX-4 complexesdefines conserved sequences involved in the regu- lation of Hox-4.4. Renucci A, Zappavigna V,ZakanyJ,Izpisua-Bel- monte JC, Burki K, Duboule D. EMBO J. 1992 Apr;11(4):1459-68. ☞ •106064 106192 (0; Regulatory) corresponds to mouse element. Comparison of mouse and human HOX-4 complexesdefines conserved sequences involved in the regu- lation of Hox-4.4. Renucci A, Zappavigna V,ZakanyJ,Izpisua-Bel- monte JC, Burki K, Duboule D. EMBO J. 1992 Apr;11(4):1459-68. ☞ •106085 106199 (1; Regulatory) HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. Zappavigna V,Renucci A, Izpisua-Bel- monte JC, Urier G, Peschle C, Duboule D. EMBO J. 1991 Dec;10(13):4177-87. ☞ •106788 108164 (0; LocusLink) ☞ •114356 115601 (0; LocusLink) ☞ •132941 133083 (0; Regulatory) HOXD4 retinoid-responsive enhancer.Invitro and transgenic analy- sis of a human HOXD4 retinoid-responsive enhancer.Morrison A, Moroni MC, Ariza-McNaughton L, Krumlauf R, Mavilio F.Dev el- opment. 1996 Jun;122(6):1895-907. ☞ full text ☞ •135623 136931 (0; LocusLink) ☞ •153152 156263 (0; LocusLink) ☞ •155768 156087 (1; Regulatory) antisense transcripts Analysis of the Hoxd-3 gene: structure and lo- calization of its sense and natural antisense transcripts. Bedford M, Arman E, Orr-Urtreger A, Lonai P.DNA Cell Biol. 1995 Apr;14(4):295-304. ☞ •159230 162103 (0; TIGR) corresponds to Tiger clusters THC522703, THC523348 ☞ •172791 174131 (0; LocusLink) ☞

Annotations legend

·· LocusLink : Blue ·· Regulatory : Orange ·· TIGR : Gray ·· NCBI : Green ·· PubMed : Red

Underlays legend

·· elementX : Yellow ·· HNF1 : LightPurple ·· RARE : LightOrange ·· HOX : LightRed ·· nuclear : Blue