Practitioner Quality Compounds Herbal Sleep Remedy

Active Ingredients Each 10mL contains extracts equivalent to: Passion Flower (Passifl ora incarnata) 2000mg (Withana somnifera) 2000mg Zizyphus (Ziziphus jujuba) 2000mg Also contains: Glycerol Ginger (Zingiber offi cinale) Lemon oil Herbal Sleep Remedy vs. no sleep; one night’s poor sleep vs. chronic problems) and • Relief of insomnia and sleeplessness the tasks and responsibilities of • May assist in falling asleep and aiding restful sleep the day. • Helps relieve nervous tension and mild anxiety • Contains herbs traditionally used in Herbal Sleep Remedy has as a sleep aid been professionally formulated Indications to assist a good night's sleep • Insomnia and sleeplessness by helping patients get to sleep, and stay asleep, so they • Prepares the body for natural sleep can wake feeling refreshed. Three key herbs have been • Nervous unrest chosen from Western, Ayurvedic and Traditional Chinese Medicine (TCM) modalities to produce a complex formula Sleep is an important part of reaching health goals. It that covers all aspects of sleep health. is essential for survival, providing rest and recuperation for the mind and body. Shakespeare called sleep In the ancient Indian system of medicine and lifestyle, ‘the chief nourisher in life's feast’. Adequate sleep is a (the science of life), sleep is considered one of primary component of a healthy lifestyle and the quest for the essential factors to lead a healthy life. In Ayurveda longevity. It is as important to wellbeing as a healthy diet the tridoshas (or energetic forces) i.e. Vata, Pitta and and regular exercise, and just as diffi cult to achieve and Kapha are described as the Tristhuna (three main pillars). maintain. Although often the undesirable result of our busy Similarly Aahara (food), Nidra (Sleep) and Bramhacharya lives, insuffi cient sleep may also be indicative of imperfect (Abstinence) are described to be the Trayopasthambas health and can itself lead to future health problems.1 (three supportive pillars). Nidranasha is the Ayurvedic term used for loss of sleep (insomnia). Acharya Charaka Most people experience some sort of sleep disturbance (born c. 300 BC) was one of the principal contributors to during their lifetime. If it happens sporadically then it is Ayurveda. He is referred to as the Father of Medicine. not a problem however; when it starts becoming a regular He said that happiness and misery, proper and improper occurrence then treatment is paramount. Whatever a growth, good strength and weakness, potency and sterility, person’s individual needs, lack of sleep or poor sleep knowledge and ignorance, and life and death of an quality can have far reaching consequences including: individual depend on proper and improper sleep.2 poor attention span, concentration and memory, irritability and other mood disturbances, impaired judgement From the TCM perspective, sleep disorders are superfi cial and reaction time and poor physical coordination manifestations of underlying imbalances of body energies. (dangerous for driving). The seriousness of these Based on the patient’s symptoms and signs, TCM effects depends on how bad the sleep practitioners describe the patterns of bodily disharmony in deprivation is (e.g. less sleep terms of eight major parameters: yin and yang, external

More full monographs available on: The www.herbalextracts.com.au Version: oct14/01 Herbal ExtractCompany of Australia Herbal Sleep Remedy full monograph and internal, hot and cold and excess and defi ciency. the constituents are considered to be important Additional systems, such as qi (life force similar to the in this respect. Dysfunction of the gamma-aminobutyric doshas in Ayurveda), blood and body-fl uid differentiation, acid (GABA - the chief inhibitory neurotransmitter in the and zang fu (organ) differentiation are also used. The top vertebrate central nervous system) system is implicated three TCM patterns in insomnia are defi ciency of both the in many neuropsychiatric conditions including anxiety heart and spleen, hyperactivity of fi re due to yin defi ciency and depressive disorders. According to a 2011 study it and liver-qi stagnation transforming into fi re.3 is plausible that binding to the GABA-site of the GABAa receptor is one mode of action of the extract.10 Animal Insomnia, or sleeplessness, is a disorder characterised behavioural models have shown non-sedative anxiolytic by a person’s incapability to fall or stay asleep for a effects.11 As a herb with anxiolytic, mild sedative, hypnotic desirable period of time.4 It is a common affl iction in and anodyne properties, passionfl ower addresses some Western societies, with the prevalence of general sleep of the major causes of insomnia which are anxiety, disturbance experienced by people over a year estimated depression and pain.8 at approximately 85%, while diagnosed chronic insomnia is estimated at around 10%.5 Almost 40% of adults Withania (Withania somnifera) with insomnia suffer from psychiatric disorders such as Withania has a long history of use in traditional Ayurvedic depression and anxiety. Insomnia is a symptom, not medicine as a tonic herb, and an adaptogen, to assist a disease, so during treatment its cause needs to be the body in adapting to various types of stress. Withania 6 identifi ed and corrected. may also assist in promoting memory, and physical and mental health. The species name somnifera means sleep- Recuperative sleep is conducive to a greater sense inducing in Latin. The in withania are said to be of wellbeing. Herbal Sleep Remedy will manage sedative and reduce blood pressure and heart rate. An sleeplessness and insomnia by promoting restful sleep Indian study explored the role of withania root extract in and improving sleep quality. The use of hypnotic, sleep-disturbed rats. The results suggest the involvement anxiolytic and adaptogenic actions in the formula will aid in of a GABA-ergic mechanism in the sleep promoting effects the restoration of sleep. Herbal Sleep Remedy also helps of withania in a sleep-disturbed state. An earlier study by alleviating nervous tension and anxiety, a key cause of by the same authors investigated the protective effect of insomnia. It can be used regularly to assist in the relief withania on the behavioural and biochemical alterations in of sleeping diffi culties without the additive side effects, sleep disturbed mice. The results suggested that withania tolerance and dependence associated with prescription root extract can be used in the management of sleep loss 7 drugs. and associated oxidative stress.12 Herbal Sleep Remedy provides a safe, effective and Zizyphus (Ziziphus jujuba) reliable treatment strategy aimed at addressing both Zizyphus is traditionally used in TCM to assist in falling the symptoms and causes of insomnia. It has a non asleep and staying asleep, for irritability, to assist in the drowsy, mild sedative action allowing patients to wake relief of anxiety and nervous exhaustion and to aid in the up refreshed. Herbal Sleep Remedy does not contain relief of excess sweating and night sweats. It is classifi ed (Valeriana offi cinalis) which is useful for those as a tranquilising herb that tonifi es yin, astringes and people who experience a paradoxical reaction to valerian, collects, anchors the yang and tonifi es the blood.13 A feeling nervous, anxious and restless after taking it instead 2013 animal study found that zizyphus has a sedative of calm and sleepy. and hypnotic effect and the mechanism may be related to regulating the content of amino acid neurotransmitters Herbal components in the hypothalamus.14 Jujuboside A has proven to be a Passion Flower (Passifl ora incarnata) major hypnotic-sedative component of zizyphus.15 Spanish conquerors of the Americas fi rst learned of passionfl ower from pre-Colombian people who traditionally Contraindications and cautions used it as a sedative to treat insomnia and nervousness. None known. They took passionfl ower to Europe where it became widely cultivated and was introduced to European folk Administration and dosage medicine becoming a popular traditional phyotherapeutic Dose: Take 10mL with water or juice before bedtime or as remedy, as well as a homoeopathic remedy, for the relief professionally prescribed. of mild symptoms of mental stress, anxiety and mild sleep For the best results, the use of two doses, with an disorder. Currently researchers believe that only a portion additional dose taken in the early evening (around 5pm), of the pharmacologically active compounds have is recommended. The initial dose will exert a hypnotic been precisely identifi ed and the mechanism of and anxiolytic effect that will prepare the body and mind action is still under discussion, although for sleep. The next dose one hour to 30 minutes before the fl avonoid and possibly sleep will boost serum levels of the constituents and, in

2 of 3 Herbal Sleep Remedy full monograph combination with good sleep hygiene techniques, should 8. Currie G, Wheat J. Insomnia: An Overview Of Herbal Treatments. facilitate sleep.16 The Internet Journal of Alternative Medicine. 2007;5(2). 9. Miroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S. Herbal Sleep Remedy may be compounded with other Passifl ora incarnata L.: Ethnopharmacology, clinical application, herbal extracts to tailor a bespoke formula for the individual safety and evaluation of clinical trials. J Ethnopharmacol. 2013 Oct patient’s requirements. 17. pii: S0378-8741(13)00698-3. doi: 10.1016/j.jep.2013.09.047. [Epub ahead of print] Herbal Sleep Remedy is a unique, pleasant tasting herbal 10. Miroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S. complex in a glycerol base. Glycerol imparts a sweet Passifl ora incarnata L.: Ethnopharmacology, clinical application, fl avour, which is enhanced with ginger and the added oil safety and evaluation of clinical trials. J Ethnopharmacol. 2013 Oct 17. pii: S0378-8741(13)00698-3. doi: 10.1016/j.jep.2013.09.047. component of lemon. A wide range of patients will fi nd this [Epub ahead of print] compound easy to take. 11. Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G. Modulation of the γ-aminobutyric acid (GABA) system by Passifl ora References incarnata L.Phytother Res. 2011 Jun;25(6):838-43. doi: 10.1002/ 1. Dr Weil Live Well [Internet]. Tempe (AZ): Weil Lifestyle; c2014[cited ptr.3352. Epub 2010 Nov 19. 2014 Jul 28] Available at http://www.drweil.com/drw/u/ART02037/ 12. Dhawan K, Kumar S, Sharma A. Anxiolytic activity of aerial and sleep-aid. underground parts of Passifl ora incarnata. Fitoterapia. 2001 2. Pokharel S, Sharma AK. Evaluation of Insomrid Tablet and Dec;72(8):922-6. Shirodhara in the management of Anidra (Insomnia). Ayu. 2010 13. Kumar A, Kalonia H. Protective effect of Withania somnifera Dunal Jan;31(1):40-7. doi: 10.4103/0974-8520.68209. on the behavioral and biochemical alterations in sleep-disturbed 3. Poon MM, Chung KF, Yeung WF, Yau VH, Zhang SP. Classifi cation mice (Grid over water suspended method). Indian J Exp Biol. 2007 of insomnia using the traditional chinese medicine system: a Jun;45(6):524 8. systematic review. Evid Based Complement Alternat Med. 14. Hempen CH, Fischer T. A Materia Medica for Chinese Medicine. 2012;2012:735078. doi: 10.1155/2012/735078. Epub 2012 Jul 30. Munich:Churchill Livingstone Elsevier 2007. p. 448. 4. Dey A, Dey A. Phytotherapy against insomnia: extravagant claims 15. Gao JR, Ji WB, Jiang H, Chen JF. [Article in Chinese] [Effects of or an alternative medicine? Pak J Biol Sci. 2013 Feb 1;16(3):148- extracts from ziziphi spinosae semen and schisandrae chinensis 50. fructus on amino acid neurotransmitter in rats with insomnia 5. Sarris J, Panossian A, Schweitzer I, Stough C, Scholey induced by PCPA]. Zhong Yao Cai. 2013 Oct;36(10):1635-9. A. Herbal medicine for depression, anxiety and insomnia: a 16. Liu Z, Zhao X, Liu B, Liu AJ, Li H, Mao X, et al. Jujuboside A, A review of psychopharmacology and clinical evidence. Eur neuroprotective agent from semen Ziziphi Spinosae ameliorates Neuropsychopharmacol. 2011 Dec;21(12):841-60. doi: 10.1016/j. behavioral disorders of the dementia mouse model induced by Aβ1- euroneuro.2011.04.002. Epub 2011 May 23. 42. Eur J Pharmacol. 2014 May 30. pii: S0014-2999(14)00403-8. 6. Roth T. Insomnia: defi nition, prevalence, etiology, and doi: 10.1016/j.ejphar.2014.05.041. [Epub ahead of print] consequences. J Clin Sleep Med. 2007 Aug 15;3(5 Suppl):S7-10. 17. Sarris J, Wardle J. Clinical Naturopathy.Chatswood 7. Ancoli-Israel S, Roth T. Characteristics of insomnia in the United (NSW):Churchill Livingstone Elsevier; 2010. p. 267-68. States: results of the 1991 National Sleep Foundation Survey. I. Sleep. 1999 May 1;22 Suppl 2:S347-53.

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