Efficient Professional and Antibody Platforms TACSTD2 Antibody Basic information: Catalog No.: UPA60264 Source: Rabbit Size: 50ul/100ul Clonality: Polyclonal Concentration: 1mg/ml Isotype: Rabbit IgG Purification: Protein affinity purified. Useful Information: WB:1:500-1:2000 Applications: ICC:1:50-1:200 IHC:1:50-1:200 Reactivity: Human Specificity: This antibody recognizes TACSTD2 protein. Immunogen: Recombinant protein. TROP-2, also known as tumor-associated calcium signal transducer 2 (TAC- STD2), pancreatic carcinoma marker protein GA733-1, membrane compo- nent 1, surface marker 1 (M1S1) or epithelial glycoprotein-1 (EGP-1), is a cell surface glycoprotein receptor. It is a single pass type I containing one thryoglobulin type-1 domain, an epider- mal growth factor-like repeat, a phosphatidylinositol binding site and tyro- Description: sine phosphorylation sites near the C-terminus. TROP-2 plays a role in tran- ducing intracellular calcium signals. It is expressed in trophoblast cells, cor- nea and multistratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells. Muta- tions in the encoding TROP-2 can result in gelatinous drop-like corneal dystrophy (GDLD) also referred to as lattice corneal dystrophy type III, an autosomal recessive disorder that causes severe visual impairment. Uniprot: P09758(Human) BiowMW: 35 kDa Buffer: 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. Storage: Store at 4°C short term and -20°C long term. Avoid freeze-thaw cycles. Note: For research use only, not for use in diagnostic procedure. Data:

Gene Universal Technology Co. Ltd www.universalbiol.com Tel: 0550-3121009 E-mail: [email protected] Efficient Professional Protein and Antibody Platforms Western blot analysis of TROP2 on A431 cell ly- sate using anti-TROP2 antibody at 1/500 dilution.

ICC staining TROP2 in A431 cells (green). The nu- clear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Immunohistochemical analysis of paraf- fin-embedded human lung cancer tissue using anti-TROP2 antibody. Counter stained with he- matoxylin.

Immunohistochemical analysis of paraf- fin-embedded human liver cancer tissue using anti-TROP2 antibody. Counter stained with he- matoxylin.

Gene Universal Technology Co. Ltd www.universalbiol.com Tel: 0550-3121009 E-mail: [email protected]