The Chemistry of Permanganate Complexes Having Reducing Ligands – Beliefs and Facts

Exploring New Horizons in Chemical Sciences-2019

IT-1

The chemistry of permanganate complexes having reducing ligands – beliefs and facts

László Kótaia*, R. P. Pawarb, Fernanda Paiva Franguellia, Péter Németha and Imre Miklós Szilágyia

aResearch Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary. bDepartment of Chemistry, Deogiri college, Aurangabad (MS) - 431 005 India.

Correspoding author: [email protected]

Abstract: Compounds containing redox active permanganate anions and complex cations with reducing ligands

(M=Ag, Cu, Zn, Cd, Fe, Ni, Cr, Co, L=NH3, pyridine, 2,2’-bipyridine and urea) are used not only as selective and mild oxidants in organic chemistry but as precursors for nanocatalyst synthesis in low- temperature solid phase redox reactions. Their synthesis in pure form is challenging due to the high reactivity of the reactants toward each other. Here we show some new synthesis methods and application fields as well. Structural studies of these complexes show that the main reason for the appearance of unusual quasi-intramolecular solid phase redox reactions observed at these complexes is the existence of hydrogen bonds (N-H…O-Mn in ammine complexes and -C-H…O-Mn in pyridine complexes) between the reducing ligands and oxidizing anions. The [M(NH3)4](MnO4)2 type complexes (M=Cu, Zn and Cd) can be transformed into transition metal manganites (MMn2O4) used as sensors in NOx or CH3SH detection (M=Cd), as catalysts in hydrocarbon processing (M=Zn) or in oxidation of methane or exhaust gases (M=Cu). The known traditional routes to obtain crystalline

MMn2O4-type spinels resulted in crystalline (micrometer size) forms due to high synthesis temperature (>500 °C). Our new method is performed around 100 °C and results in amorphous and highly defective nanosized spinel catalysts with superior activity. The pyridinesilver complexes result in

Ag/Mn3O4 composites can be used as a catalyst in an anticancer drug (Gefitinib) manufacture.

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IT-2

Exploring methodology and molecular hybridization strategies against communicable and noncommunicable diseases

Prof. Rajshekhar Karpoormath

Departemnt of Chemistry, University of KwaZulu-Natal, Durban, South Africa.

Email: [email protected]

Abstract:

Quinazolinones are important heterocyclic scaffolds that are core moieties of many biologically active molecules and are privileged structures in drug development. These are widespread in both natural products and pharmaceuticals and are core structures in several marketed drugs such as Methaqualone, Etaqualone, Afloqualone, Chloroqualone, Quinethazone, Fluproquazone, Tiacrilast, Raltitrexed etc.We herein report a simple and highly efficient microwave-assisted, copper-catalyzed and ligand-free synthetic method for 2-substituted 4(3H)-quinazolinones as domino reaction. This reaction proceeds via self-condensation of substrate (2-bromo/iodobenzamide) in the presence of a strong base and copper catalyst. The substituted quinazolinones were obtained in one-pot reaction by intramolecular cyclization (condensation) via Ullmann–type intermediate. Both the intermediates and quinazolinones were obtained in good yield and can be further used as building blocks for developing the potential novel drug-like compounds. Tuberculosis is a chronic necrotizing bacterial infection caused by Mycobacterium tuberculosis (Mtb), which has been a bane to humanity for centuries and remains as one of the rampant health problems in the world. We here in report design and synthesis of styryl hydrazine thiazole hybrids from dehydrozingerone (bearing styryl portion) by hybridization approach as potential antimycobacterials against Multi Drug Resistance strains of Mtb.

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IT-3

A Step towards Sustainable Polymers: Utilization of Cashew Nut Shell Liquid (CNSL) and Lignin-Derived Aromatic Chemicals for Synthesis of Difunctional Monomers Suitable for Preparation of High Performance Polymers.

Prakash P. Wadgaonkar

Polymers and Advanced Materials Laboratory, Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411 008 E-mail: [email protected]; [email protected]

Abstract: Polymer is one of the most versatile materials having myriad of applications - from packaging to biomedical devices. Of late, the glittering concept of ‘sustainability’ has been able to infiltrate within the domain of polymer science and technology to significant extent - in both academia and industries. This field continues to grow rapidly. Along with polymer, other ingredients that are used to make polymer compounds and products would also be sustainable in future. Sustainable materials are defined as materials that can be produced without depletion of non-renewable resources and without disturbing the equilibrium between the environment and key natural resource systems. The range of these materials is huge - from natural rubber, bio-derived monomers and polymers to recyclable materials, etc. How the future polymeric materials could be developed using scientific principles would be discussed in this presentation. It is also interesting to demonstrate how science is helping to restore environment and society. The objectives of our research program since the last ten years have been to design and synthesize monomers and polymers from agricultural waste products, utilize bio-based monomers for synthesis of high performance polymers and understand structure-property relationship. In this context, cashew nut shell liquid (CNSL) and lignin-derived aromatic chemicals were explored as renewable starting materials to generate a library of difunctional monomers suitable for preparation of high performance polymers. These results will be covered in the presentation.

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IT-4

Chemistry of 1, 2, 3-selenadiazoles and their utility in nanotechnology

Pawan K Khanna

Quantum Dots R & D Lab, Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Ministry of Defence, Govt. of India, Girinagar, Pune-411021, India.

* Email: [email protected]

Abstract: The present lecture deals with various aspects of 1, 2, 3-selenadiazole and their role in materials chemistry and nanotechnology. The significance of selenadiazole will be highlighted throughout the session by adopting various experimental strategies. Chemistry of organoselenium compounds will be discussed by taking specific examples of a variety of selenadiazoles in order discuss their materials applications. Many reported and new semicarbazones and selenadiazoles will be covered in detail by rapid solventless practices. For example, the syntheses of bis(cycloalkeno)-1,4-diselenins from the corresponding cycloalkeno-1, 2, 3-selenadiazoles by a solvent-free microwave irradiation method will bring new ideas and information to the participants. The reactions of selenadiazoles with metal salts for useful semiconductor nanoparticles. Cd (II) and Zn (II) complexes as precursors for the preparation of the corresponding metal selenide quantum dots will be explained. Like wise the synthesis of magic-sized and regular sized quantum dots using different series of 1, 2, 3-selenadiazoles will be discussed along with polymorphs of selenium from cycloocteno- 1, 2, 3-selenadiazole by microwave irradiation. Understanding of organoselenium compounds, organometallic chemistry, inorganic chemistry, and materials chemistry will thus be effectively created in the minds the participants and other audience.

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IT-5

Transition State Models for Understanding Asymmetric Catalysis

Raghavan B. Sunoj

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076 India. Email: [email protected]

Abstract: Computational quantum chemistry has been increasingly employed toward rationalizing the stereochemical outcome in catalytic reactions. The approach typically involves the identification of kinetically significant transition states and intermediates. In our laboratory, ab initio as well as DFT methods are employed to gain insights into carbon-carbon and carbon-heteroatom bond-forming reactions of immediate practical significance. The key objective of our research is to gain molecular insights on the factors responsible for stereoselectivity and to exploit such insights toward in silico design of novel asymmetric catalysts. A number of examples wherein the conventional transition state models required systematic refinements toward accounting the observed product distribution and stereochemical outcome will be presented. Through this talk, we intend to propose the need for a timely rethink on a number of working hypotheses on asymmetric induction that places an over-emphasis on steric interaction. In general, the presentation would encompass a few contemporary themes in the domain of asymmetric multi-catalytic reactions. Interesting interpretations/rationalizations of experimental observations besides meaningful guidelines for rational improvements in the design of asymmetric catalysts would remain the key focus of the presentation. The contents are designed to cater to a broad and diverse group of audience; hence, the chemical insights would be emphasized, rather than a labyrinth of technical details.

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IT-6

Chemistry and Biology of Heterocycles: Few Examples from Our Journey towards Drug Discovery and Diagnostics

Dr. Srinivas Kantevari

CSIR- Indian Institute of Chemical Technology, Hyderabad, INDIA

E-mail: [email protected], [email protected]

Abstract: Heterocycles form by far the largest of classical divisions of organic chemistry and are of immense importance biologically and industrially. The vital interest of the pharmaceutical and agrochemical industries in heterocycles is often connected with their natural occurrence. The majority of pharmaceuticals and biologically active agrochemicals are heterocyclic while countless additives and modifiers used in industrial applications ranging from cosmetics, reprography, information storage and plastics are heterocyclic in nature. One striking structural features inherent to heterocycles, which continue to be exploited to great advantage by the drug industry, lies in their ability to manifest substituents around a core scaffold in defined three dimensional representations. More than 90% of new drugs contain heterocycles and the interface between chemistry and biology, at which so much new scientific insight, discovery and application is taking place is crossed by heterocyclic compounds. In this talk we discuss various natural and synthetic heterocyclic compounds and their analogues used in our laboratory for molecules towards drug discovery, development and diagnostics.

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IT-7

Recent research activities on environmental remediation using nanotechnology

C. Subramaniam

Department of Chemistry, Indian Institute of Technology Bombay, Powai Mumbai 400076.

Email: [email protected]

Abstract: The last two decades has seen the discovery of several nanomaterials ranging from one-dimensional carbon nanotubes to two-dimensional, homo-atomic and hetero-atomic nanosheets. These nanomaterials, in their isolated form, exhibit exotic properties such as ballistic electron transport, high specific surface area, exceptionally high thermal conductivity and high tensile strength. Translating these properties from their isolated state to ensembles and assemblies has been a major roadblock for realizing practical applications of these materials. For instance, an isolated single wall carbon nanotube (CNT) exhibits a thermal conductivity of ~ 4000 W/mK which degrades by more than 99% to 1 W/mK when present as ensembles. Our research activities at IIT Bombay focuses on developing ‘frugal’ scientific concepts and approaches for realizing applications of such materials. We adopt a top-down approach and target specific scientific applications of global and societal relevance using such ‘frugal’ approach. Specifically, I will be discussing our results using CNT-yarns and threads for developing applications towards ultra-efficient and rapid desalination of saline water using energy-efficient methods. The next part of the talk would focus on engineered nanocarbon surfaces for highly efficient adsorption-based removal of heavy metal ions from water streams. Such surface engineered nanocarbons exhibit the synergistic combination of morphological structure and chemical functionality for simultaneous scavenging of multiple heavy metal ions. Both these applications are realized by synergistically combining the high specific surface area and high electrical conductivity of carbon nanotube assemblies. The underlying scientific concepts to realize such frugal innovations would be discussed. Fundamentals of electrochemical non-Faradic energy storage systems and structure of double layer would be covered in this talk.

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IT-8 Supramolecular Chemistry: Organic Functional Structures on the Nanoscale Level Prof. Sheshanath V. Bhosale Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206 India.

Email: [email protected] Abstract: Machinery of life was developed biologically in long-term evolutionary processes, and there is no protocol about the experiments, which finally succeeded. Chemists have been successful with synthesis, isolation and analysis but not with the reproduction of the working molecular apparatus. The introduction of supramolecular self-assembly approach as an engineered phenomenon allowed us to address one of the great challenges on nanoscale level – the separation, containment and manipulation of individual molecules and allow studying molecular interactions, which would make it possible to answer some simple biological questions experimentally on nanoscale level, which are difficult to approach in complex biological modules. Supramolecular chemistry offers a paradigm shift for fundamental chemical research through hybridisation of organic, physical, inorganic, theoretical and biological sciences that focused on the development of emerging technologies for creation of functional material.1 For supramolecular self- assembly and self-organization of small organic molecules, new synthetic strategies are employed, whereby designer building blocks self-associate in a predictable fashion to form cutting edge materials. As a part a more diverse research program within our group in supramolecular chemistry, my team has been exploring new approaches to combating several unanswered questions in sciences. For example: 1) Can small molecules are sensitive and selective enough for sensing applications? 2) Are small molecules a valid approach for development of luminescent material? 3) Can the Photosynthetic Reaction Centre (PRC) effectively mimicked by synthetic systems for energy transduction? 4) Are small molecules a valid approach for molecular electronics? In this presentation, I will highlight the work of my team based on small organic molecules and present their achievements in relevant fields.2-4 This talk will focus on discussion of innovative and cutting- edge research program on smart functional material on the nanoscale level and their applications such as molecular recognition, environmental (purification, separation), energy (solar cells), and drug delivery.

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IT-9

Preparation and unexpected transformations of [tetraamminecopper(II)] molybdate Fernanda Paiva Franguelli1,2, Imre Miklós Szilágyi2, Rajendra P. Pawar3 and László Kótai1 1Department of Inorganic and Analytical Chemistry, Budapest University of Technology, Budapest, Hungary 2 MTA TTK Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary 3Deogiri College, Department of Chemistry, Deogiri College, Aurangabad-431005, India Email: [email protected]

Abstract:

Preparation of [Cu(NH3)4MoO4 and its solid and solution phase tranformations have been studied.

[Cu(NH3)4]MoO4 was subjected to moisture of open air at room temperature. Light blue orthorhombic

[Cu(NH3)(H2O)3]MoO4 was formed in 2 days as a result of an unexpected solid/gas phase ammonia−water ligand exchange reaction. This complex does not lose its last ammonia ligand on further standing in open air; but a slow quasi- intramolecular (self)-protonation reaction takes place producing a yellowish-green microcrystalline material, which has been identified as a new compound,

[NH4Cu(OH)MoO4]. The mechanisms of the sequential ligand exchange and the self-protonation reactions were clarified by ab initio quantum-chemical calculations and deuteration experiments. The

[Cu(NH3)(H2O)3]MoO4 intermediate transforms into NH4Cu(OH)(H2O)2MoO4, then two waters are lost with yielding of [NH4Cu(OH)MoO4]. Upon heating, both [Cu(NH3)4]MoO4 and

[Cu(NH3)(H2O)3]MoO4 decompose and stable [Cu(NH3)MoO4] is formed.

NH4Cu(OH)(H2O)2MoO4 can also be prepared by boiling the saturated aqueous solution of

[Cu(NH3)4]MoO4. All properties of [NH4Cu(OH)MoO4] match those of the active photocatalyst described earlier in the literature under the formulas (NH4)2[Cu(MoO4)2] and (NH4)2Cu4(NH3)3Mo5O20.

The NH4Cu(OH)(H2O)2MoO4 has been characterized with various spectroscopical and other analytical (IR, Raman, XPS, UV, TG-MS, DSC, XRD) methods.

[Cu(NH3)4]MoO4 ? [NH4(Cu(OH)MO4]

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IT-10

Key Elements in Antibiotic Research

Dr. Mahesh Patel

Wockhardt Research Centre, Aurangabad.

Abstract: Antibiotics have proved being not only lifesaving drug class but also the great enabler of bio-medical advance and very useful tools in fundamental biological research in the area of molecular biology and genetics. However the global spread of AMR has created scientific challenges in the discovery of new antibiotics and the world has been facing declining output of new antibiotics over last two decades. In the light of such scenario, the talk would cover the key elements of antibiotic research and what it takes to discover and develop a new antibiotic effective against contemporary multidrug resistant pathogens.

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IT-11

Role of Fluorine Chemistry in Pharmaceutical Drug Design

Dr. Nishikant D. Ghadge

Drug Development & Discovery Divison, Navin Pharma, Navin Fluorine Pharma Ltd, Dewas (M. P.) India.

Email: [email protected]

Abstract: The fluoro and fluoroalkyl groups are significant in chemistry dealing with pharmaceutical drug development, agrochemicals and speciality chemicals. Fluorine-containing compounds are part of many human-made materials, from the polymer Teflon used to coat pots and pans to medical drugs. Fluorine is the kingpin of drug discovery and many of the modern drugs contain one or more fluorine atoms. The role of fluorine in drug design and development is expanding rapidly as we learn more about the unique properties associated with this unusual element and how to deploy it with greater sophistication. The wide ranging applications of fluorine in drug design are providing a strong stimulus for the development of new synthetic methodologies that allow more facile access to a wide range of fluorinated compounds shall be discussed.

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IT-12

Flavopiridol analogues: CDK inhibitors and anticancer agents.

Dr. Jalinder Totre Drug Development & Discovery Divison, Navin Pharma, Navin Fluorine Pharma Ltd, Dewas (M. P.) India.

Email: [email protected] Abstract: Flavopiridol and its synthetically manipulated derivatives are flavonoid based anticancer agents targeting CDK’s. Flavopiridol is first synthetic flavonoid based (Rohitukine) on the extract from an Indian plant developed for potential treatment of cancer whose first clinical trials were initiated in 1994 as a frontline combination therapy for leukaemia. It is a potent Cyclin Dependent Kinase (CDK) inhibitor with preferential activity against CDK9. Several phase I and II trials using flavopiridol as a single agent and in combination with standard chemotherapeutic regimens and various tumor types are ongoing. Moreover, the combination of flavopiridol with gemcitabine, imatinib mesylate, SN-38 (the active metabolite of CPT-11) and doxorubicin show synergistic therapeutic effect in inducing mortality of cancer cells. Present study enlightens preparation of its derivatives and their anticancer properties, mostly towards CDK inhibition.

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IT-13

Chemically designed Nanomaterials for Thermoelectric Applications

Priyesh Vilas More* Department of Applied Chemistry, DIAT, Pune -411025.

Email: [email protected]

Abstract: Nanomaterials of metal oxides and quantum dots are a high end research target in nanotechnology including solar cell, thermoelectric and light emitting diode applications. Similarly, nanomaterials showing thermoelectric (TE) properties have attracted growing attention due to direct conversion between thermal energy to electrical energy. The Thermoelectric devices have been recognized for reducing global energy consumption, a long time solution and highly promising transformative technology. These energy utilizations are ecofriendly and non-polluting thus, such devices attract great attention by the global research and industrial communities. The present talk is based on designing and development of various nanoparticles, quantum dots and their composites for advanced application in area of thermoelectric devices. For this purpose, various materials such as light emitting II-VI metal chalcogenide Quantum dots, ZnO nanoparticles, TiO2 nanoparticles were synthesized with altered properties. In order to maximize the efficiency, the composites of these materials with conducting polymers such as PANI, PPY and PEDOT:PSS and/or RGO were also explored. A total approach “synthesis to application” will be presented describing the role of each material and parameter in the process.

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Oral Presentations

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OP-1 Synthesis of Sm doped CaWO4 phosphor using microwave initiated solid state metathesis A.M. Mukea*, S.V. Moharilb a Asst. Professor, Avvaiyar Government College for Women, Karaikal- Puducherry- India bEx- Professor, PGTD of Physics, RTM Nagpur University, Nagpur- India

Corresponding author: [email protected] Abstract: A novel microwave initiated solid-state metathesis synthesis of metal tungstates has been investigated. In solid state metathesis reaction, high lattice energy of NaCl drives the metathesis reaction (CaCl2·Sm +Na2WO4→2NaCl + CaWO4.Sm) in the forward direction to obtain the product. No extra fuel like urea is added to initiate combustion reaction. Thus, solid state metathesis using microwave technique is successfully employed to synthesize CaWO4: Sm phosphor. Simple and basic model microwave oven generally used in kitchen with output power of 900 W and frequency 2.45 GHz could be used for this preparatory technique. The alkaline–earth metal tungstates with chemical formula AWO4 (A = Ca, Sr, Ba) are excellent host materials and are found to be having good chemical and thermal stability due to the fact that W6+ is coordinated by four oxygen atoms in tetrahedral symmetry. Compound formed by this technique was characterized for crystallinity and morphology by X-Ray diffraction technique. 3+ Photoluminescence is also checked for this sample. CaWO4 doped with Sm can emit two intense 3+ 6 4 broad band with a maximum at 339 nm and 405 nm corresponded to Sm H5/2  L17/2 (339 nm) and 6 4 H5/2  K11/2 (405 nm) transitions respectively. An efficient blue emission is seen when it is excited by sources like ultraviolet radiation, x-rays, cathode rays, etc. Tungstates are used in many optical applications, such as solid-state laser, scintillator in medical devices and fiber-optical communication.

OP-2 One-pot synthesis of pyrazolo [3, 4-b] quinolines accelerated by Bakers yeast Anusaya S. Chavana, Arun S. Kharatb, Manisha R. Bhosalea, Sambhaji T. Dhumala and Ramrao A. Manea*

aDepartment of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India -431004 bDepartment of Microbiology, School of Life Sciences,Jawaharlal Nehru University. New Delhi, India 110067. Email: [email protected]

Abstract: Pyrazole and its derivatives are gaining importance in medicinal and organic chemistry. They have displayed broad spectrum of pharmacological and biological activities such as anti-bacterial, anti- depressant, and anti-hyperglycemic. Quinoline derivatives are found to possess anti-malarial, anti- inflammatory, anti-tuberculosis and anti-breast cancer activities. In view of the above therapeutic significance of pyrazoles and quinolones and considering need of alternative synthetic protocol, first time an efficient and greener protocol for the synthesis of pyrazolo[3,4-b]quinolines has been developed, allowing a cyclocondensation of 2-chloro-3-formyl quinolines and hydrazine hydrate/phenyl hydrazine in aqueous medium in the presence of readily available whole cell biocatalyst, Bakers yeast (Saccharomyces cerevisiae) at room temperature. This novel protocol is eco-friendly and cost effective. The details of the optimisation, role of catalyst, and advantages of the developed protocol will be shared.

O NHNH2

H Yeast, rt N H2O N N R N Cl R

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OP-3 Synthesis of thin film nanocomposite (TFN) membrane for enantiomer separation Pravin G. Ingole*, Swapanali Hazarika Chemical Engineering Group, Engineering Sciences and Technology Division, CSIR-North East Institute of Science and Technology, NH 37, Pulibor, Jorhat, Assam 785006, India. *Corresponding author: [email protected]

Abstract Enantiomer separation has always been a subject anxious by chemical and pharmaceutical societies. Enantio-selective polymeric membranes with high mechanical stability, enhanced surface area, tailored pore size, measured morphology shows the superior chiral recognition performance [1-3]. The enhanced enantiomeric separation of racemic intermediate compounds has been validated by the membrane based chiral resolution method using polysulfone flat sheet as well as hollow fiber membranes as a substrate material and chiral selective layer primed in situ by interfacial polymerization. The thin nanocomposite layer was prepared using a mixture of dibasic amino acid i. e. L-lysine and chiral carbon nanotube (CNT) with polyfunctional aromatic carbonyl chloride (1, 3, 5-Benzenetricarbonyl trichloride) on the top of polysulfone membrane. One of the exciting researches to the development of membrane for the separation of enantiomers using membrane technology for continuous separation is developed. The studies were carried out for diverse ratios and concentration of monomers and chiral CNT for membrane preparation, range of separation conditions were examined and optimum conditions for enantio-separations of racemic mixture of amino acids by thin film nanocomposite membranes were determined. The concentration of monomer along with nanoparticles and their ratio pointedly affected the enantio-separation performance of composite membrane [4-7]. The optical resolution of α-amino acids was performed in pressure driven process. Membrane permeates 98% enantiomeric excess for D- enantiomer of amino acids. All prepared TFN membranes were well characterized by various physicochemical techniques. The experimental study has been done at variable experiment conditions.

Fig. 1 Schematic representation of enantio-selective thin film nanocomposite chiral membrane prepared by interfacial polymerization.

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OP-4

Charaterization and Biodegradation Study of Bioplastic Synthesized using Sabudana as Starch Source

A. M. Kulkarni*, T. G. Joshi, O. U. Pendharkar Gogate Jogalekar College, Ratnagiri, 415612, Maharashtra, India

Corresponding author: [email protected]

Abstract Adverse impact of petroleum based plastic on environment has triggered the research in the field of bioplastic. Bioplastics are biodegradable materials derived from renewable biomass sources such as starch, cellulose, wood, sugar etc. There are basically two types of bioplastics: bio based plastic and biodegradable plastic. Bio based plastic is synthesized in whole or in part from renewable sources whereas biodegradable plastic may or may not be synthesized from renewable sources but have property of degradability. In present communication, bio based plastic samples have been prepared using sabudana as starch source. Four different compositions of bioplastic have been synthesized using sabudana as main constituent along with few materials like fly ash that will strengthen the bioplastic. The synthesized bioplastic films have been characterized by techniques like Infra-Red spectroscopy (IR), X-Ray Diffraction technique (XRD), Scanning Electron Microscope (SEM). The tensile strength of synthesized materials has been checked. Biodegradation study of synthesized material has also been carried out.

Keywords: Bioplastic, Sabudana, Fly-ash, Biodegradation study

OP- 5 Study of temperature effect on sensitivity of ammonia sensor based on Polythiophene Ashish B. Chourasia1,a *, Deepali S kelkar2,b and Vasnat V Chabukswar3, c 1 Electronic Science Department H. P. T. Arts and R. Y.K. Science College, Nashik-05 2Department of Physics, Govt. Institute of Science, Civil Lines, Nagpur, India. 3Department of Chemistry, Nowrosjee Wadia College, 19, V K Joag Path, Pune – 411001, India.

*Corresponding author: [email protected], [email protected] Abstract: Polythiophene has been chemically synthesized by using 2,5-dibromothiophene as a chemical precursor. The synthesized polymer was characterized by UV-Visible spectroscopy, FTIR and X-ray diffraction for its structural and morphological studies. Two probe method was used to calculate conductivity (σ) of polythiophene. D. C. electrical conductivity value of polythiophene was 2.067 X 10-9 S/cm. Log σ versus 1/T graph show semiconducting behavior of the sample. Ammonia (500 ppm and 1000 ppm) gas sensing was carried out using polythiophene at various temperatures ranging from room temperature (280C) to 1500C and also at various voltages from 1 V to 15 V. After exposure to ammonia the change in resistance of sensor was recorded as a function of time. At 500 ppm and 1000 ppm of ammonia gas polythiophene shows maximum sensitivity (S) at 1000C. Graph of % S versus voltage show maximum sensitivity at 1000C. The sensor shows maximum sensitivity (16%) at 1000C for 1000 ppm concentration of ammonia gas.

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OP-6 Synthesis of some new Heterocycles and their antimicrobial studies. S. Shah N. N.*, M. A. Baseer P.G. Department of Chemistry, Yeshwant College Nanded, Maharashtra (India). *Corresponding author: [email protected] Abstract: Chalcones are the important constituent of natural sources. They are firstly named by Kostanecki and Tambor. Chalcones posses 1, 3-diaryl-1-ones skeleton which withdraws the credit of biological importance. Chalcones are impossible to isolate from plants because it is converted into flavonones due to the presence of enzyme chalcone synthetase. The most employed method for the synthesis of chalcones is the Claisen-Schimdt condensation of equimolar ratios of aldehyde and ketone in presence of alkali. Chalcones are used as an intermediate for the synthesis of many heterocycles such as pyrimidines, pyrazolines, benzodiazepines, flavonone , isoxazoline, benzoxazolone, quinolines, indolinones etc thus being the precursor for the wide range of such type of bioactive molecules chalcones itself exhibits biological activities such as antimalarial , antiviral , antifungal , anticancer , cardiovascular and others . With this view we reported here the synthesis of some new Heterocycles by using chalcones which was synthesized by Clasien-Schimdt condensation of substituted ketones and 4-Piperidin-1-yl-benzaldehyde in presence of alkali at room temperature. These newly synthesized Heterocycles were screened for their antimicrobial studies which show moderate to good activity.

OP- 7

Studies on metal drug zidovudine (Azt) complexes with calcium (II) and some amino acids. 1K. R. Borude and *2B. C. Khade 1Department of Chemistry, K.K.M. College, Manwath Dist. Parbhani (M.S.) 431505, India. *2 Department of Chemistry & Research Centre, D.S.M. College, Parbhani (M.S.) 431401, India.

*Corresponding author: [email protected] Abstract: The metal ions play an important function in the biological systems and their complexation with the drugs is responsible to influence the bioavailability and some physiological properties. In the present investigation, stability constant of first approved anti retroviral drug zidovudine (AZT) used for the treatment of HIV with Ca (II) metal ion and some biologically important ligands such as L-glycine, L- alanine, DL-valine and DL-leucine studied by pH metrically at temperature 27 ± 0.1 0C and ionic -3 strength of 0.1 mol dm NaClO4. Ternary complexes are formed by a stepwise mechanism and concentration distribution curves of the various binary and ternary species in a solution were evaluated as a function of pH. The metal ion-AZT complexes formed through the nitrogen of the azide group explained on the basis of the species distribution curve.

Keywords: Zidovudine, Equilibriums; Binary complexes; Ternary complexes; Stability constants.

O HO NH

N O -N O N+ O N

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 18 Exploring New Horizons in Chemical Sciences-2019

OP- 8 Swertia densifolia flower extract as a dose-dependant attractant or repellent for Apis florea. Pradnya Deshpande* and Vasi Shaikh MIT WPU, Pune 38. *Corresponding author: [email protected] Abstract: Work towards developing attractants for Indian honey bees is an area of interest for researchers. As a result of this, number of commercial products has reached the market. Most of these products are either food based or pheromone based and a very few are derived from plant extracts. Similarly, the repellents for honeybees are also equally important as these compounds can keep honeybees away from certain areas; especially if they have been sprayed with toxic insecticides. The chemical constituents of Nasonov gland pheromone of the Indian honey bee Apis cerana indica were investigated and the attractant formulations were developed. The lures of A. florea were subsequently developed along similar lines. However, the activity of these lures was found to be limited to a very small range of concentrations of formulations. For this reason, alternate attractant formulations were researched. It is a common observation of beekeepers from Western Maharashtra that the plant Swertia densifolia (Griseb.) (Gentianaceae) is frequently visited by honeybees in their foraging activity. The genus Swertia contains 170 known species found in India. S. densifolia, commonly known as ‘Chirayata’ is a well- known Indian medicinal plant. As a part of present work, the properties of ethanolic flower extract on A. florea are studied. Ethanolic flower extract showed dose dependent repellent properties at lower concentration and attractant properties at higher concentrations. OP- 9 Simple, efficient and one-pot synthesis of different Tetra cyclic heterocycles pyrazolo imino pyrimido pyrazole. Sirsat Shivraj B*., Jadhav Anilkumar G., Chavan Nilesh B.,Vartale Sambhaji P. P.G. Research centre, Department of chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (MS) India.

*Corresponding author: [email protected] Abstract: We report simple and efficient synthesis of novel fused tetra cyclic hetrocyclic compounds Pyrazolo imino pyrimido pyrazole using 2,6-diimino-4,8 bis (methylthio) -2,6 dihydro-1H–pyrimido[1,2-a] pyrimidine-3-carbonitrile with hydrazine, substituted phenyl hydrazine and substituted hydrazino benzothiazole using potassium carbonate in DMF as a solvent under reflux condition to give 2N-7N- disubtituted-3,8-diamino-4,9-dimino-pyrazolo-[3,4-d]-pyrimido-[1,2-b]-1H-pyrimido-[4,5-c]-pyrazole. .

Keywords: Addition elimination reaction, pyrimido pyrimidine. Substituted hydrazine, Pyrazolo Pyrazole . R SCH3 N N CN NH N N 2 K CO , DMF NH N NH NH -NH-R 2 3 NH 2 Reflux, 6 h NH N HN SCH3 HN CN N N H N 2 R

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 19 Exploring New Horizons in Chemical Sciences-2019

OP-10

Greener approach for the synthesis of 3, 4-dihydropyrano[c]chromene derivatives using Envirocat-EPZG as an efficient catalyst under solvent- free conditions Surekha N. Deshmukha, Murlidhar S. Shingareb* a Department of Chemistry, Jawaharlal Nehru Engineering College, Aurangabad- 431 003, M.S., India. b* Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad- 431 004, M.S., India.

E-mail: [email protected]

Abstract: An efficient green protocol has been developed for the synthesis of 3, 4‐dihydropyrano[c]chromene derivatives involving the one‐pot three‐component reaction of 4‐hydroxycoumarin, malononitrile and aromatic aldehydes in the presence of Envirocat EPZG as a catalyst under solvent-free condition. There are several distinct advantages to this protocol, including high yields, short reaction time, operational simplicity and preclusion of toxic solvent.

Keywords: 3,4-dihydropyrano[c]chromene, Envirocat EPZG, Three-component reaction, Green protocol, Microwave irradiation.

OP-11

Green Synthesis of Nickel Nano particles and its Characterization

1 1 2 1* Vinod Lohakane , Ratnakar Hole , Sandesh Jaybhaye Achut Munde , 1Department of Chemistry, Milind College of Science Aurangabad MS-431001 2Department of Chemistry, B. K Birla College, Kalyan MS-421304.

*Corresponding Author: [email protected]

Abstract: Transition metal nanoparticles have diverse applications in different types of fields. These particles have structure with optical, catalytic and electronic properties. Nickel nano particles (NNPs) can be synthesized by physical and chemical methods. In this work Nickel nanoparticles are synthesized by using Green method. In aqueous solution of Nickel nitrate (1M) Azadirachta indica leaves extract is slowly added and ultra sonicated for 1Hr at 80oC. The solution is then directly heated and dried to get Nickel oxide powder. As obtained nickel oxide was then reduced to nickel at different range temperature (700- 900oC) in hydrogen atmosphere with varyingtemperature for getting different quality of NNPs.NNPswas then characterized by(XRD)X-ray diffraction,SEM (Scanning Electron Microscope) and FTIR (Fourier Transform Infra-Red Spectroscopy). Itwas found that the quality of nickel nanoparticles varies with different experimental conditions.

Keywords: Nickel nano particles, Green method, Ultra sonicated, Azadirachta indica, X-ray diffraction

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 20 Exploring New Horizons in Chemical Sciences-2019

OP-12

Chemical analysis of pigment produced by Haloalkalotolerent bacteria Paracoccus beibuensis SL2 Deepti D. Dhere1 and S. M. Dharmadhikari2 1Government Institute of Science, Aurangabad, (M.S.), India 2Government College of Arts and Science, Aurangabad, (M.S), India *Corresponding author: [email protected] Abstract: Crater, Buldhana, Maharashtra, India and was identified by conventional and advanced techniques. The 16s rRNA sequence was deposited to NCBI GenBank with accession number KY129665. In recent studies the bright orange pigment produced byParacoccus beibuensis SL2 was extracted and purified. The analysis of purified pigment was done by spectrophotometric method, chemical method, TLC, FT- IR and HPLC to know the chemical nature of pigment. The acetone extract of bright orange pigment showed maximum absorption at 480 nm with one peak spectra and broad shoulder region which indicates xanthophyll group pigment. The chemical test showed presence of polyene group in pigment. The TLC analysis showed similar RF value (0.74) with that of standard carotenoid from xanthophyll group i.e. trans-astaxanthin. The FT-IR analysis showed peaks at1739, 3380, 1647 and 1349 cm-1 which are stretching frequency values for O=C<, -OH, -C=C- and -C-C- group respectively which again confirms the xanthophyll nature of the carotenoid. The HPLC analysis of the pigment showed first major peak at 3 min. which was for all trans-astaxanthin and is major constituent of the pigment extract. The retention time matches with the retention time value of standard pigment trans-Astaxanthin. The overall studies showed that bright orange pigment produced by Paracoccus beibuensis SL2 is a carotenoid group pigment which is mainly a xanthophyll pigment showing similar characters with that of Astaxanthin which has a great commercial value as a natural colorant and therapeutic molecule.

OP- 13

Enantioselective organocatalytic synthesis of the chiral chromenes by domino oxa-Michael-aldol reaction Shrikant S. Pendalwar, Avinash V. Chakrawar, Sudhakar R. Bhusare* Department of Chemistry, Dnyanopasak College, Parbhani-431 401, MS, India *Corresponding Author: [email protected]

Abstract: The proline based chiral organocatalyst has been found to be an efficient catalyst for enantioselective domino oxa-Michael-aldol reaction. This catalytic system provided the synthesis of substituted 2-aryl- 2H-chromenes-3-carbaldehyde in good to high yields (73%-90%) with excellent enantioselectivity (up to 97%) and reasonable reaction times. The atom economy, high yield and mild reaction conditions are some of the important features of this protocol.

CHO CHO CHO i) + Activation via iminium intermediate OH Hydrogen bonding interaction O R R R1 1 2 Chiral pyrrolidine carbon skeleton

R2

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 21 Exploring New Horizons in Chemical Sciences-2019

OP-14 An Eco-friendly Approach for the Synthesis of Biodegradable Plastic from Potato Starch 1Sandip Rathod* 2Mulik Suraj, 3Khawale Vaibhav Deapartment of Chemistry, PDEA’S, Waghire College, Saswad, Tal: Purandar, Dist: Pune-412 301 *Corresponding Author: [email protected]

Abstract: Plastic pollution is accumulation of plastic products in the environment that adversely affect wild life habitat Humans, Animals. Plastic is acts as a major pollutant because the degradation of plastic are naturally not possible. Chlorinated plastic can release harmful chemicals in the surrounding soils. This can causes serious harm to living organism. The plastic in ocean degrade but not entirely in this process toxic chemicals such as Bisphenol-A, Polystyrene can cause serious effect on aquatic life. If plastic pollution not controlled, in future it shows very adverse effect on all living organism. Some researchers suggest that up to the year 2050, there could be more plastic than Fishes in ocean by weight. Therefore there is a need to replace polymer plastic and find another way to use biodegradable plastic from potato starch instead of polymer plastic. In the production of biodegradable plastic a starch extraction first carried out from potato using distilled water, after drying starch powder is obtained. The starch powder is used to make biodegradable plastic treating with hydrochloric acid and glycerol. The synthesized biodegradable Plastic from potato starch were characterized by modern instrumental techniques such as XRD, FT-IR, and SEM etc. This is a simple, easy and eco-friendly approach for synthesis of biodegradable plastic and it has many applications in daily life such as plates and dinnerware, making degradable plastic bags, cups, bowls etc.

OP-15 Iodine- DMSO Catalyzed Chemoselective Aromatization of tetrahydro-β- carbolines-3-carboxylic acid: Concise approach to synthesis of marine β- carboline alkaloids Sunil V. Gaikwad, Rohit Shinde, Milind D. Nikalje and Pradeep D. Lokhande* Center for Advance Studies, Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India. Corresponding Author: [email protected], [email protected]

Abstract: A novel protocol for a significantly improved practical and chemoselective aromatization of tetrahydro- β-carboline-3-carboxylic acids to unpredicted aromatic -β-carboline-3-carboxylic acids with catalytic + 25 mol % of I2 in DMSO/ H . The method was also successfully extended for the aromatization of tetrahydro- β-carboline-3-methyl esters &one-step synthesis of Marinacarbolines-D-analog.

Present Method. Metal free O O Chemoselective Oxidative aromatization I2 (25 mol%), NO-decarboxylation Liturature + OH report OH H , DMSO 25 mol% of molecular iodine Widely available, inexpensive, N NH N N o N Non- toxicity materials. N H 0-80 C, 1-2 h. H H R R R Up to 75% yield No External Oxidant 2a -2k 1 2a R = Ph, hetero

Liturature report, IBX-CeCl3, IBX, PhI(OAc)2, I2 in DMF, TCCA, NBS, NCS, DDQ, KMNO4 O K Cr O , S, SeO , MnO etc 2 2 7 2 2 N Oxidative decarboxylation H R = Use of External Oxidant N N MeO OMe ° HN Temp above 100 C H R OMe

Utility for the Syntheis of Hybrid Marinacarbolines-D analog reduce number of steps. Two step, High yield,

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 22 Exploring New Horizons in Chemical Sciences-2019

OP- 16 Facile synthesis of triazole thiazolidinone hybrids and it's a biological evaluation. Yogesh Patil,a Ramesh Shingare,a Amit Choudhari,b Dhiman Sarkar,b Balaji Madjea, * aDepartment of Chemistry, Vasantrao Naik Mahavidyalaya, Aurangabad 431003, Maharashtra, India bCombi Chem Bio Resource Centre, National Chemical Laboratory, Pune 411 008, India *Corresponding author: [email protected] Abstract: In the present investigation, a series of triazole thiazolidinone derivatives 6a-o were efficiently synthesized and characterized by IR, NMR (1H and 13C) and mass spectral analysis. Triazole thiazolidinone core moiety active methylene group treated with the aromatic aldehyde to get benzylidene derivatives (6a-o) by the Knoevenagel condensation reaction. Synthesized compounds 6a-o were inspected for their in vitro antitubercular activity against Mycobacterium tuberculosis (MTB) H37Ra using an established XTT Reduction Menadione assay (XRMA) both active and dormant state.The titled compounds exhibited minimum inhibitory concentration (MIC90) ranging from 1.52 to > 30 (µg/mL). Six compounds (6d,6e, 6l, 6m, 6n, and6o) were further confirmed from their dose- dependent effect against MTB. These compound were evaluated in THP-1 infection model where 6d (MIC90= 6.12µg/mL),6e (MIC90= 7.45µg/mL), 6l(MIC90= 4.11µg/mL), 6m(MIC90= 0.95µg/mL)and6o(MIC90=1.35µg/mL)demonstrated significant antitubercular activity. All the ex vivo active compounds showed insignificant cytotoxicity againsthuman cancer cell lines, HeLa, MCF-7 and THP-1.It also screened for antimicrobial activity against gram-positive or gram-negative bacteria. The results obtained suggest that reported compounds can provide a novel pharmacophore to synthesize lead compounds against tuberculosis and antimicrobial activity.

OP-17 Microwave assisted synthesis and antimicrobial studies of 2, 5 disubstituted 1, 3, 4-oxadiazole derivatives Bharat K Dhotre *1, Murtaza A. Patharia2, Santosh V. Raut3, Pathan Mohd Arif3 1Department of Chemistry, Swami Vivekanand Senior College Mantha, Maharashtra, India 2 Navin Research and Innovation Centre, NFIL Surat, Gujarat, India. 3Department of Chemistry, Maulana Azad College Aurangabad, Maharashtra, India.

*Corresponding author: [email protected]

Abstract: An rapid and efficient microwave-accelerated synthesis of fluorinated 2,5-disubstituted 1,3,4- oxadiazoles by reaction of 2,4-diflubenzohydrazide with substituted benzoic acid in presence of ceric ammonium nitrate in PEG. The synthesized compounds were evaluated for their antibacterial and antifungal activities, compared with ampicillin and fluconazole as standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Out of the compounds studied, compounds 5b, 5c, 5e and 5f showed significant inhibition, while compounds 5a, 5d, 5g and 5i showed moderate activity. The structural elucidation of these compounds is done by spectral data (IR, 1H NMR and MS). Advantage of the method is that the yield is good to excellent and the process is rapid.

Keywords: Microwave irradiation, ceric ammonium nitrate, polyethylene glycol (PEG), antibacterial activity, antifungal activity

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 23 Exploring New Horizons in Chemical Sciences-2019

OP-18 Stress-Strain Characteristics of Brick Masonry Prepared with Pond Ash in Cement Mortar Under Uniaxial Compressive Strength Dhirajkumar Lala, Aniruddha Chatterjee*,b, Arunkumar Dwivedi*1,c aPh.D. Student, Civil Engineering, North maharashtra University, Jalgaon-425001, India bAssociate Professor, Department of Plastic and Polymer Engineering, Maharashtra Institute of Technology, Aurangabad-431010, India cProfessor, CED, School of Engineering & Technology, Sandip University, Nasik-422002, India *Corresponding Author: [email protected]

Abstract: The waste from coal based thermal pawer plant in the form of pond ash is collected and utilized in the formation of environment friendly cement mortar with sand and cement. The current experimental work demonstrates the behavior of brick masonry, and cement mortar prepared with the replacement of pond ash in cement mortar. The pond ash is replaced in mortar with cement and sand with various replacement percentages. Mechanical property likes compressive strength under uniaxial loading of brick, mortar and brick masonry prism is conducted. The mathematical relationship of compressive stress between brick, mortar and masonry is developed for all the percentage of replacement. The compressive stress, strain and young’s modulus is calculated and a relation between young’s modulus and compressive stress is developed. The increase in the strength is observed in the mortar and brick masonry prism prepared with the replacement of pond ash. The pond ash generated by various thermal power plant causes a threat to environment; hence it is necessary to find the suitable way to dispose such a waste in a very useful purpose of improvement in the property of cement mortar. Keywords: Pond ash; cement mortar; compressive strength; Young’s modulus.

OP-19 Green synthesis of conducting polymer nanocomposites: Ultra-sensitive gas sensor and catalyst in organic synthesis Vasant V. Chabukswar* 1Department of Chemistry, Nowrosjee Wadia College, 19, V. K. Joag Path, Pune-411001, *Corresponding Author: [email protected] Abstract: Among the class of the nanocomposite materials of conducting polymers, polyaniline and its substituted derivatives have been commonly applied as a chemical sensor materials owing to their very good sensitivity, selectivity at room temperature and good environmental stability. Synthetic approach using natural organic acids such as tartaric acid, citric acid, lactic acid and oxalic acid provides several advantages as compared to strong inorganic acids such as HCl, H2SO4 and HNO3more eco-friendly and close to green route. The transition metal polymer nanocomposites are synthesized, characterized by using FT-IR, XRD, SEM techniquesand new smart, flexible sensors have been developed in our laboratory for detection of hazardous chemical vapours like NH3, NO2, H2S, and Cl2.We have also used the polymer and its nanocomposites for organic synthesis as recyclable catalyst and reduced time for the synthesis of highly bioactive organic heterocyclic molecules. Keywords: Conducting polymer, transition metal nanoparticlesnanocomposite, ultarsensitive sensor,heterogeneous catalyst, green route

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 24 Exploring New Horizons in Chemical Sciences-2019

OP-20 Synthesis of ethyl-4, 7-dihydro-7-aryl-5-phenyl-[1, 2, 4]-triazolo-[1, 5-a]pyrimidine-6- carboxylate derivatives. Shivaji S. Pandit, Amit S. Waghmare Research Centre and Post Graduate Department of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce, Pravaranagar, Ahmednagar, Maharashtra 413713, India *Corresponding author: [email protected] Abstract: Multi-component reactions (MCRs) have played a very important role in the synthesis of polyfunctionalized heterocyclic bioactive compounds. Heterocyclic compounds having purine and pyrimidine scaffolds show various biological and pharmaceutical activities. 1, 2, 4-Triazolo [1, 5-a] pyrimidine derivatives are obtained by modified Biginelli reaction in which analogous of amino azoles are used instead of urea/thiourea. 1, 2, 4-triazolo [1, 5-a] pyrimidine and its derivatives have remarkable therapeutic and pharmaceutical activities such as analgesic, anticonvulsant, anti-inflammatory, antimalarials, antimicrobials and antifungal effect. Furthermore, the chemistry of 1,2,4-triazolo[1,5- a]pyrimidines have received great attention due to their structural similarity with purines and hence several 1,2,4-triazolo[1,5-a]pyrimidines exhibited anticancer activity. The structural modification of these nitrogen-containing heterocyclic scaffolds is of considerable interest for both organic and medicinal chemistry. In the synthesis of 1,2,4-triazolo[1,5-a]pyrimidines the interactions of 3-amino- 1,2,4-triazole with aldehydes and a number of acyclic 1,3-dicarbonyl compounds, namely ethyl acetoacetate, methyl acetoacetate and ethyl trifluoro acetoacetate have been previously investigated. In some methods product obtained in two successive steps. OP-21 Silica Nanoparticles: An Efficient and Reusable Catalyst for Synthesis of 2, 3- Dihydroquinazolin-4(1H)-one Derivatives in Aqueous Medium Praveen V. Shitre, Rajkumar R. Harale, Bhaskar R. Sathe, Murlidhar S. Shingare Yeshwantrao Chavan College of Arts, Commerce and Science, Sillod. *Corresponding author: [email protected] Abstract: Silica Nanoparticles catalyzed an efficient protocol for the Synthesis of 2, 3-Dihydroquinazolin-4(1H)- one Derivatives in aqueous medium has been developed. This method offers rapid, relatively economical and ecofriendly protocol for the synthesis of 2, 3-Dihydroquinazolin-4(1H)-one for the first time. As synthesized catalyst was characterized by using different spectroscopic techniques like IR, XRD and TEM. Moreover, the catalyst can also be easily recovered and recycled with no loss of catalytic activity. . OP-22 Synthesis of Spiro[fluorene-9,9’-xanthene] and Cyanopyridone Functionalities as a Non-fullerene Electron Acceptor Gajanan G. Kadama and Sheshanath V. Bhosale*b aShri Datta ACS College, Hadgaon, Dist-Nanded bDepartment of Chemistry, Goa University *Corresponding author: [email protected] Abstract: We have synthesized structural fragments, spiro[fluorene-9,9’-xanthene] small molecule non-fullerene electron acceptor, (5Z,5'Z,5''E,5'''E)-5,5',5'',5'''-((((S)-spiro[fluorene-9,9'-xanthene]-2,2',7,7'- tetrayl)tetrakis(thiophene-5,2- diyl))tetrakis(methaneylylidene))tetrakis(4-methyl-1-octyl-2,6-dioxo- 1,2,5,6-tetrahydropyridine-3-carbonitrile) [A1] we have synthesized for bulk heterojunction as an electron acceptor with different types of donor molecules. A1 displayed promising optoelectronic properties, and energy levels complementing those of the conventional donor polymers poly(3- hexylthiophene) [P3HT] and Poly({4,8- bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b’]dithiophene-2,6- diyl}{3-fluoro-2-[(2 ethylhexyl)carbonyl]-thieno[3,4- b]thiophenediyl}) [PTB7]. Given its energy levels, solubility and excellent film forming capability, A1 was used in bulk- heterojunction devices as an n-type semiconducting component. The device performances [D: A 1: 1.2 = 5.84% (P3HT); 7.21% (PTB7)] validated the design and use of A1 as an efficient non-fullerene acceptor. It is fully characterised NMR and Mass spectroscopy. International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 25 Exploring New Horizons in Chemical Sciences-2019

OP- 23 Hydrogen as source of Energy - Production methods Himanshu Patil1, Vishnu A. Gite2 1,2MGM’S Jawaharlal Nehru Engineering College, N-6, Cidco, Aurangabad Corresponding author: [email protected] Abstract: Hydrogen is simplest element in existence and it is also one of the most abundant elements in the earth’s crust. Hydrogen as a gas is not found naturally on Earth and must be manufactured. Natural hydrogen is always associated with other elements in compound form such as water, coal and petroleum. Since hydrogen does not exist on Earth as a gas, it must be separated from other compounds. Two of the most common methods used for the production of hydrogen are electrolysis and steam reforming. Steam reforming is currently the least expensive method for producing hydrogen. It is used in industries to separate hydrogen atoms from carbon atoms in methane. The other method for the production of hydrogen is electrolysis. Electrolysis involves passing an electric current through water to separate water into its basic elements, hydrogen and oxygen. Unfortunately, electrolysis is a very expensive process. Besides regular electrolysis, electrolysis using microbes is another possibility with biocatalysed electrolysis, hydrogen is generated after running through the microbial fuel cell and a variety of aquatic plants can be used. These include reed sweet-grass, cord-grass, rice, tomatoes, lupines, and algae. Using biomass to extract hydrogen, the moisture content should be kept below a certain level by drying or supercritical steam gasification. Photoelectrolysis uses photoelectrochemical light collecting systems to power the electrolysis of water. When exposed to sunlight, a semiconductor photoelectrode, submerged in an aqueous electrolyte, will generate sufficient electrical energy to promote hydrogen and oxygen evolution reactions. Biomass can also be processed to make renewable liquid fuels, such as ethanol or bio-oil, which are relatively convenient to transport and can be reacted with high-temperature steam to produce hydrogen at or near the point of use. Coal is an abundant and relatively inexpensive domestic resource. It is important to note that hydrogen can be produced directly from coal via gasification, rather than by using coal-generated electricity to produce hydrogen. Hydrogen fuel is a zero- emission fuel when burned with oxygen. It can be used in electrochemical cells or internal combustion engines to power vehicles or electric devices. Hydrogen is renewable energy sources and is virtually non-polluting. Hydrogen has great potential as a way to reduce reliance on imported energy sources such as oil. OP- 24 Atom-Efficient, Solvent-free, Green Synthesis of 1, 3-diaryl-2-propene containing benzyloxy phenyl ring system by Grinding Method Sainath Zangade a and Pravinkumar Patil b aDepartment of Studies in Chemistry, Madhavrao Patil ACS College, Palam, Dist. Parbhani-431720 (M S) India. bDepartment of Chemistry, N.E.S. Science College, Nanded (MS) India-431605. *Corresponding author: [email protected]

Abstract: A simple, rapid, efficient, and environmentally benign procedure for synthesis of 1,3-diaryl-2-propene has been described by reacting substituted 2’-hydroxyacetophenone with substituted benzyloxy aldehydes under solvent-free grinding technique. The short reaction time, cleaner reaction, easy workup, higher yields, and mild reaction conditions make this protocol practical and economically attractive in comparison with the classical reaction.

OH OH O R COCH3 1 NaOH H Grinding at R.T. R1 5-8 Mins. + OHC R2

H R2 X X

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OP- 25

Benzene sulfonamide pyrazole clubbed oxadiazole hybrid as potential antimicrobial and antitubercular agents Ramesh Shingare,1 Yogesh Patil,1 Jaiprakash Sangshetti,2 Rajesh Patil,3 Dhanji Rajani,4 Balaji Madje1, * 1Department of Chemistry, Vasantrao Naik Mahavidyalaya, Aurangabad 431003, Maharashtra, India 2Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad 431001, Maharashtra, India 3Sinhgad Technical Education Society's, Smt. Kashibai Navale College of Pharmacy, Pune 411048, Maharashtra, India 4Microcare Laboratory and Tuberculosis Research Center, Surat 395003, Gujarat, India *Corresponding author: [email protected]

Abstract: A novel series of Benzene sulfonamide pyrazole clubbed 1,3,4-oxadiazole hybrids have been synthesized by reaction of 4-(5-(3-fluoro-4-methoxyphenyl)-3-(hydrazinecarbonyl)-1H-pyrazol-1-yl) benzenesulfonamidewith different substituted benzoic/pyridinyl/indolyl acids in phosphorous oxychloride, characterized by IR, 1H NMR, 13C NMR, MS analytical data and evaluated for their antimicrobial as well as antitubercular activity. Molecular docking studies against Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase A, (Kas-A) was carried out to understand the possible mode of its inhibition and potential of synthesized compounds as antitubercular agents. Antibacterial activity of compounds 5d (4-(3-(5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl)-5-(3-fluoro-4- methoxyphenyl)-1H-pyrazol-1-yl)benzenesulfonamide) and 5f (4-(3-(5-(2,4-dichlorophenyl)-1,3,4- oxadiazol-2-yl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl)benzenesulfonamide) were found good against E. coli, P. aeruginosa, S. aureus and S. pyogenes as compared to standard Ampicillin. Compound 5d (4-(3-(5-(3-chlorophenyl)-1, 3, 4-oxadiazol-2-yl)-5-(3-fluoro-4-methoxyphenyl)-1H- pyrazol-1-yl) benzenesulfonamide) was found active antitubercular agents against M. tuberculosis H37Rv.

OP- 26 Analytical Determination of Antioxidant & Acidity Regulator as Additives in Fruit Juices Available in Indian market Shazia Khanum Mirza, Sayyad Sultan Kasim Maulana Azad College of Arts, Science and Commerce, Aurangabad (M.S) India *Corresponding author: [email protected] Abstract: The increasing demand for ready-to-drink juices has led to challenges for food distributors regarding the safety & quality of their foods hence Food additives are added to foods to keep them fresh ,control its pH & improve the flavour, texture, colour or chemical preservatives, taste & appearance. The present work aimed Quantitative determination of additives as ascorbic acid & citric acid contents in a variety of fruit juices available on the Aurangabad market using the classical titration method, in order to check whether the current uses of these additives are accordance to the Food Safety & Standard Authority of India. Consuming too much amount of vitamin C may increase the amount of oxalate in your kidneys which has the potential to lead to kidney stone problem. The high intake of citric acid leads to stomach pain, diarrhoea, nausea or vomiting, increased sweating & fast heart rate, vomiting . In this study we had selected 14 different popular juice samples which are mostly consumed by the Indian children. The objective of this research was to evaluate the physical & chemical parameters. Each sample was analyzed for organoleptic or physical test such as colour, texture, flavour, taste & pH. These findings indicated that the current use of ascorbic acid & citric acid in all juices by the fruit juice industry is in below permitted limit of FSSAI and are safe for the consumption of Indian children.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 27 Exploring New Horizons in Chemical Sciences-2019

OP- 27

11-molybdo-1-vanadophosphoric acid: An efficient catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones under ultrasound irradiation Laxmikant D. Chavana, Sunil G. Shankarwarb*

a Department of Chemistry, Jawaharlal Nehru Engineering College, Aurangabad- 431 003, M.S., India b* Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad - 431 004, M.S., India.

a Corresponding author: [email protected]

Abstract: A one-pot three-component condensation of ethyl acetoacetate, aldehydes and urea in the presence of 11-Molybdo-1-vanadophosphoric acid catalyst under ultrasound irradiation have been carried out to form the corresponding 3,4-dihydropyrimidin 2(1H)-ones in high yields. The 11-molybdo-1- vanadophosphoric acid (H4PMo11V1O40) was prepared and characterized by FT-IR spectroscopy, thermal analysis and XRD analysis techniques. The present method offers advantages such as simple work-up, shorter reaction time, excellent yields, recovery and reusability of catalyst.

Keywords: 3, 4-Dihydropyrimidin-2(1H)-ones, Heteropoly acids, 11-Molybdo-1-vanadophosphoric acid, Ultrasound irradiation. OP- 28

Zinc Ferrite Magnetic Nanoparticles: A versatile Catalyst for Microwave Irradiated solvent free Synthesis of Chalcones Ravikumar M. Boradea, Swati B. Kaleb, Pavan R. Shindec, Rajendra P. Paward aDepartment of Chemistry, The Institute of Science, Mumbai (M.S.) India 400032 bDepartment of Applied Science, Government Polytechnic, Aurangabad (M.S.) India 431004 cDepartment of Chemistry, Govt. College of Arts and Science, Aurangabad (M.S.) India 431001 dDepartment of Chemistry, Deogiri College , Aurangabad (M.S.) India 431004 Email: [email protected] Abstract: A highly efficient magnetically recoverable nano zinc ferrite catalyst was fabricated via sol-gel auto combustion method. The synthesized nanocatalyst has been fully characterized by X-ray powder diffraction, scanning and transmission electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), FT-IR, UV-Visible, Photoluminescence (PL), thermal study (TGA-DTA), magnetic, dielectric study, and Brunauer-Emmett–Teller (BET) isotherm method. Zinc ferrite nanoparticles having high saturation magnetization, high dielectric constant, good colloidal stability, high specific absorption rate (SAR) and a monodispersed nature. All these properties Zinc nanoferrite become as excellent candidate for microwave absorption. Chalcones are natural products possess various bioactivities that are widely found in the different plants. An efficient and versatile microwave irradiated solvent free synthesis of chalcone derivatives has been developed using magnetic and high dielectric zinc nanoferrite catalyst. The salient features of this new protocol are solvent free reaction, cost effective, environmental friendliness, absence of work-up step, high yields, short reaction times and recovery and reuse of zinc ferrite nanocatalyst. O O O

H ZnFe2O4 MNP's R' R' R" MW, Solvent free R"

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 28 Exploring New Horizons in Chemical Sciences-2019

OP- 29 Novel organic Fluorophores: Synthesis, Characterization and Aggregation-Induced Emission Enhancement Sandeep Jadhav, Balaji Madje*

Department of Chemistry, Vasantrao Naik Mahavidyalaya, Aurangabad (MS) 431003, Maharashtra, India.

Corresponding author: [email protected] Abstract: A series novel organic Fluorophores with different color have been synthesized by reaction of Substituted (1-hydrazonoethyl)-[1,1'-biphenyl]-4-ol with different Substituted Benzaldehyde and Substituted acetophenone, in presence of ethanol and catalytic amount of acetic acid. Synthesized compounds was characterized by IR Spectroscopy, 1H-NMR, 13C-NMR, HR-MS analytical data and evaluated for Aggregation Induced Emission Enhancement (AIEE) characteristics.

OP-30 Use of Ultrasonic Interferometer to Study Solvent-Solvent Interaction in an Aqueous Medium at Different Temperatures Sanjeev. R. Dudhat*1, Sonali S. Chine2, C. S, Patil3

1Engg. Sciences, SRES’s, College of Engineering, Kopargaon, SPPU, Pune, Maharashtra, India 2Engg.Sciences, SRES’s, College of Engineering, Kopargaon, SPPU, Pune, Maharashtra, India 3Department of Chemistry, Deogiri college, Aurangabad, Dr.BAMU, India.

Corresponding author: [email protected], [email protected]

Abstract: Theoretical velocities of ternary liquid mixtures of Acetone + Propanol-2 + Chloroform have been evaluated at 308.15, 313.15, and 318.15 K. The basic parameters like viscosity (η), density (ρ) and velocity (U) can be measured by ultrasonic Interferometer. From these three parameters various thermodynamical and acoustical parameters such as specific acoustic impedance (Z), Intermolecular free length (Lf), adiabatic compressibility ‘s (β) etc can be estimated using standard relations from measured values of Ultrasonic viscosities, densities and velocities in the wide range of concentrations at different temperatures for Acetone + Propanol-2 +chloroform tertiary system. The solvent-solvent interactions are studied on the basis of increase or decrease in ultrasonic velocity, density, viscosity and other derived acoustical parameters in terms of structure making and structure breaking tendencies of various solvent molecules.

Keywords: Density, Ultrasonic Interferometer, Ultrasonic Velocity, Viscosity, Water Bath

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 29 Exploring New Horizons in Chemical Sciences-2019

OP-31 A Green Protocol for Benzimidazole Synthesis using Fly Ash as Reusable Catalyst Sonali S. Chinea, C. S. Patil*b and Rajendra P. Pawarb a. Department of Engineering Sciences, SRES Sanjivani College of Engineering (S.P.P.U, Pune), Kopargaon, Dist. Ahmednagar, (M.S.) 423601, India. b. Department of Chemistry, Deogiri College (Dr. B.A.M.U., Aurangabad), Aurangabad, M.S., India, *Corresponding Author: [email protected] Abstract: This paper reveals greener protocol for the synthesis of benzimidazoles by cyclocondensation of aromatic aldehydes and orthophenylene diamine in presence of Na2S2O5 and fly ash as heterogeneous, reusable catalyst in solvent ethanol:water; by means of microwaves.

OP-32 Efficient And Thermally Stable For Pervoskite Solar Cells Material As Naphthalenediimide-Based Small Molecules. Sopan M. Wagalgavea, Avinash L. Puyad, Sheshanath V. Bhosale, Sidhanath V. Bhosalea* a Poymers and functional material Division and Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Technology, (CSIR-IICT) Hyderabad-500007. *Corresponding author: [email protected], [email protected]

Abstract: Organic-inorganic hybrid material with lead halide (CH3NH3PbI) Pervoskite has been widely investigated in optoelectronics properties both theoretically and experimentally. We design and synthesis of thermally stabilized material for Pervoskite solar cells with the help of Novel naphthalenediimide motifs. To replace the expensive PCBM in inverted Pervoskite solar cells (PSCs), herein we demonstrated two Naphthalenediimide (NDI) based novel molecule of W-3 and W-4, and found that the inverted Pervoskite solar cells with W-3 and W-4 as an electron transporting layer can reach a power conversion efficiency (PCS) up to 7.6 % and 9.2%, respectively and in This passivation results in less charge recombination, therefore delivering a higher Voc and PCE.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 30 Exploring New Horizons in Chemical Sciences-2019

OP-33 Synthesis and Characterization of Cobalt Nanoparticles by Wet Chemical Method Ratnakar Hole1, Vinod Lohakane1, Achut Munde1* and Sandesh Jaybhaye2 1Department of Chemistry, Milind College of Science, Aurangabad MS-431001 2Nanotechnology Research Lab, Department of Chemistry, Birla College, Kalyan MS-421304 *Corresponding author: [email protected] Abstract: Cobalt nanoparticles were produced by using the wet phase reduction method. The effect of urea and alkali additives on the formation and growth mechanism of cobalt nanoparticles was investigated. The Co-precipitation method was employed in the laboratory for synthesis of cobalt catalyst. The cobalt nitrate salt and urea (1:2) was mixed in little quantity of distilled water and heated at 400°C in muffle furnace with constant stirring. As obtained cobalt oxide was powdered and reduced to Cobalt nano particles in hydrogen gas at different temperature (700- 800oC). The synthesized nano-catalyst was further evaluated using key analytical techniques viz. XRD (X-ray Diffractometry), FTIR (Fourier Transform Infra-Red Spectroscopy) and SEM (Scanning Electron Microscopy). Further studies were done to conclude the impact of varying reducing temperatures and the mole ratio of metal salt and Urea.

OP-34 Performance of baker’s yeast in the preparation of beverage obtained by fermentation of honey Gauri Kallawar *1 Ganesh Pandhre 1 Suyog Pande 2 1Department of chemical technology, Dr.Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra-431005 Institute of Chemical Technology, Matunga, Mumbai 2 *Corresponding author: [email protected] Abstract: Beverage is an important part of diet in majority of countries. The art, craft and science of beverage making is regarded as special area of study. Honey has potential to provide innovative beverages. The drink prepared by fermenting honey is popularly known as mead. It is an alcoholic beverage. The process of mead making has been practiced in many parts of the world. History has in store many experiments of this simple and popular drink. However the simplicity and complexity of mead making process needs to be readdressed. There is need to pay attention to the science of mead making. In the present work efforts are made to characterize the beverage prepared from fermentation of honey. The parameters like specific gravity, alcohol strength, total dissolved solids, conductivity, alcohol percentage, degree of fermentation, haze value etc are determined. In the experiment dry yeast is used for fermentation. The challenges of the process are discussed. For farmers honey bees will serve dual purposes as pollinators and as a source of honey bee products. Also this may prove to be good source of income for farmers. The work is done to promote the idea of simple product manufacture with easily available ingredients in region.

Keywords: Beverage, mead, honey-bee products, fermentation, Saccharomyces cerevisiae.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 31 Exploring New Horizons in Chemical Sciences-2019

OP-35 Ultrasonicator Assisted Rapid and Facile Green Synthesis of Gold Nanoparticles: Study of its Application for Detection of Extracted Dichlorvos Residue from Different Samples Spectrophotometrically

Indranil Suryawanshi, Mayuri Kolhapure, Dr.S.G. Pande, D.S.Bhagat* Department of Forensic Chemistry and Toxicology, Government Institute of Forensic Science, Aurangabad-431005 (M.S.) *Corresponding author: [email protected]

Abstract: Gold nanoparticles (Au-Nps) were synthesized from Chloroauric acid (HAuCl4) using leaf extract of Citrus Limonum. This protocol was found to be simple, efficient, faster and greener approach by using ultrasonication in an aqueous medium and aqueous leaf extract of Citrus Limonum. The use of renewable aqueous solvent, reducing biocatalyst and ultrasonicator assisted method, seems to be a green chemical approach for synthesis of gold nanoparticles with well controlled size, structure and shape. The advancement in science and technology in past few decades has also increased applications of nanoparticles remarkably. By this the emerging field nanoscience could be interestingly introduced in Forensic Science. The compounds of gold and gold nanoparticles contribute excellently in detection of fingerprint and illicit drugs. This method not only enhances visual detection but also helpful for qualitative and quantitative analysis of organophosphate insecticide, “Dichlorvos” extracted from different samples like soil, cloth etc. as well as body fluid samples. The characterization of synthesized gold nanoparticles was done by EDS, FE-SEM, UV-VIS, TLC and FT-IR.

OP-36

Silica Supported Polyphosphoric Acid Catalyzed Synthesis of Substituted Indazole Raut S V*1. Dhotre B K2. Tidke A D1. More S P3. Pathan Mohd Arif1. 1Maulana Azad College and Research Center Rouza Bagh Aurangabad (M.S.) India. 2Swami Vivekanand Sr. College Mantha, Jalna (M.S.) India. 3Late. Ku. Durga K. Banmeru Science College Lonar (M.S.) India. *Corresponding Author: [email protected]

Abstract: A simple and clean methodology developed for the synthesis of substituted indazoles using silica supported polyphosphoric acid (PPA-SiO2) catalyzed condensation reaction between substituted 2- hydroxy benzaldehydes or acetophenones and hydrazine hydrate or phenylhydrazine. The reaction conditions are optimized for different solvents at different temperatures. The yield of the products improved to 88 to 90 % using silica supported polyphosphoric acid as catalyst which is reusable, cost effective and simple to synthesize.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 32 Exploring New Horizons in Chemical Sciences-2019

Poster Presentations

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 33 Exploring New Horizons in Chemical Sciences-2019

PP-1

Synthesis and Evaluation of F-18 Labeledc RGD Peptides viaCopper-free Click Chemistry for micro PET Imaging Study.

Dr. Sachin U Kalme1 1Department of Chemistry, S.S.J.E.S., ACS College, Gangakhed, 431514, MS, India Shri Sant Janabai Education Society’s ACS College, Gangakhed, Dist. Parbhani-431514 (MS)

Corresponding author: [email protected]

Abstract: A series of 18F-labeled cRGD peptides have been developed based on chemo-orthogonal strain- promoted cycloaddition using aza-dibenzocyclootyne-substitutedmono- and di- cRGD peptides as 18 precursors with F-azide synthon for positron emission tomography (PET) imaging of tumor αvβ3 integrin expression. In this study, the SPAAC reaction and subsequent chemo-orthogonal purification reaction with azide resin proceeded quickly and selectively under physiologically friendly reaction condition (i.e., toxic chemical reagents-free, aqueous medium, room temperature, pH≈7), provided 18F- labelled tumor targetable bioactive peptides in high radiochemical yield and high specific activity. In vitro binding assay and in vivo PET molecular imaging study using the 18F-labelled mono-, di- cRGDpeptides also demonstrated successful application of our 18F-labeling protocol.

Keywords: Integrinαvβ3; RGD multimer; tumor angiogenesis; Catalyst-free click chemistry; Fluorine- 18; RGD Peptide labeling; PET imaging

PP-2

Impact of mobile chemistry Apps onTeaching, Learning and Research Ravindra S. Shinde*, Rupali Rajendra Patil Department of Chemistry, Dayanand Science College, Latur-413512, Maharashtra, India.

*Corresponding author: [email protected]

Abstract: The mobile chemistry Apps useful for learning, Teaching and research process. Our objective on this ongoing research program the implementation of smartphones Apps for improving their research, teaching and learner process. It was applied to a theoretical course taught. The accessibility of Chemistry apps on smartphones and other portable electronic devices affords chemical experts and chemistry student’s powerful and compact tools to solve problems.

Keywords: Electronic Device, mobile apps, m-classroom, M-tesching

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 34 Exploring New Horizons in Chemical Sciences-2019

PP-3

Synthesis, spectral study, characterization of Cobalt (II) and Copper (II) complexes of chalcones

S. N. Ipper1, N. K. Raut2, P. P. Dixit3, G. K. Kakade4 1Dept. of Chemistry, Sunderrao Solanke Mahavidyalaya, Majalgoan Dist.Beed (India) 2Dept. of Physics, Sunderrao Solanke Mahavidyalaya, Majalgoan Dist. Beed (India) Corresponding author: [email protected], [email protected].

Abstract: Metal complexes of Co(II) and Cu(II) have been synthesized with newly prepared biologically active ligands. These ligands were prepared by the Claisen-Schmidt condensation method of 2, 6, dihydroxy acetophenone and 5-methyl-2-furaldehyde. The structures of the complexes have been proposed by the analytical data, conductivity measurement, magnetic moment, IR spectrum, Electron absorption spectrum, thermal studies and XRD analysis. Analytical data confirmed 1:2 stoichiometry and the electronic spectral data, IR, magnetic moment, TG-DTA suggest that Co(II) and Cu(II) complexes has octahedral geometry. Presence of coordinated water molecules in Co(II) and Cu(II) complexes is confirmed by TG-DTA studies. The conductivity data show that all these complexes are non electrolytes. Microbial activities of complexes with selected bacterial strain carried out and the results have been compared with commercial standards. In this paper we prepare chalcone of 5-methyl furfural by Claisen-Schmidt condensation method and synthesize Co(II) and Cu(II) metal complexes and characterize them by Infra red, Electronic absorption spectra, magnetic susceptibility, CHO analysis, solution conductivity, XRD study, TG-DTA and microbial activity.

PP-4 Synthesis, spectral characterization, molecular docking, antioxidant and antimicrobial screening of 1, 3-diones with their metal (II) complexes

D. M. Suryawanshia, D.N.Gaikwadb, R.K.Manjulb, P.D. Kashidb, A. S. Rajbhojc, S. T. Gaikwad *c aDepartment of Chemistry, Rayat Shikshan Sanstha’s S.S.G.M. College, Kopargaon, bDepartment of Chemistry, Rayat Shikshan Sanstha’s S.S.G.M. College, Kopargaon, cDepartment of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (M.S.), India 431 004 Corresponding author: [email protected]

Abstract: Three series of 1, 3-diones 4(LA- LC) and their transition metal complexes 5LA (a-e), 5LB (a- e) and 5LC (a-e) have been synthesized, spectroscopically characterized and their in vitro efficacies were evaluated. Bidentate ligands were derived from substituted aromatic acids and substituted ortho hydroxy acetophenone under ultrasound irradiation methods at low temperature. The simple substitution reactions between the metal nitrate and ligands yielded the titled complexes. However, in situ procedure gives high yield with formation of single products as evident by TLC. Elemental analysis, IR, 1H and 13C-NMR, Mass spectra, UV-Vis., magnetic susceptibility and conductance measurements were done to characterize the ligands and their metal complexes. All the evidences suggested that the complexes have octahedral geometry. The stoichiometry of the complexes was found to be 1:2 (metal: ligand). The antioxidants activity of the ligands and their metal complexes have been carried out using DPPH free radical scavenging activity and found to be most effective. The antibacterial and antifungal activity of the ligands and their complexes have been carried out and on the basis the molecular docking study against the peptide deformylase of the most effective complexes has been reported.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 35 Exploring New Horizons in Chemical Sciences-2019

PP- 5 Equilibrium Studies of Binary Complexes of sulfanilamide

Shaikh Abdul Rahim1*, Mazahar Farooqui2

1Dept. of Chemistry, Milliya Arts, Sci. and Management College, Beed 2Dept. of Chem. Dr. Rafique Zakariya College for Womens, Aurangabad

*Corresponding Author: [email protected] Abstract: Study reports interaction between selected metal ions with sulfanilamide in aqueous media at room temperature pH metrically involving Irving Rossoti titrimetric method. Use of cheap and easily reagents NaNO3 and HNO3 are the salient features of the work. Protonation and stability constant values are determined. Order of stability determined which is in agreement with Irving Williams Natural order.

Keywords: Irving Rossoti method, stability constant

PP- 6

Multicomponant synthesis of xanthene derivatives using TBAHS with their biological studies

Sunil S. Choudhare1, Gopinath S. Khansole 2, Ashok R. Karad3, Navanand B.Wadwale4 and Vijay N. Bhosale*4

1. Department of Chemistry, S.D. College, Soegaon, Aurangabad (M.S.) India. 2. Department of Chemistry, D. A. B. N. Arts & Science College, Chikhali, Sangli (M.S.) India. 3. Department of Chemistry, M.G. College, Ahmedpur Latur (M.S.) India. 4. P. G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded (M.S.) India. Email-id: [email protected]

Abstract: Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. A simple, efficient and green protocol has been developed for the synthesis of xanthane derivatives.The reaction of dimedone with various substituted aromatic aldehydes afforded the corresponding substituted xanthene derivatives. Reaction proceeds via initial Knoevenagel, subsequent Michael addition reaction and final cyclization reactions using tetra butyl ammonium hydrogen sulphate (TBAHS) as a catalyst. Short reaction time, environmentally friendly procedure, no need to use cumbersome apparatus for the purification of the products and excellent yields are the main advantages of this procedure. Synthesized compounds were screened for their Antimicrobial activity. These newly synthesized compounds were evaluated by their spectral analysis.

Keywords: Dimedone, Aromatic aldehyde, MCRs, TBAHS, xanthene etc.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 36 Exploring New Horizons in Chemical Sciences-2019

PP-7

One-pot three components synthesis of pyrazolo[3,4-b] quinoline derivatives catalysed by L-proline 1 2 1 3 Vijay N. Bhosale* , Sunil S. Choudhare , Navanand B.Wadwale , Ashok R. Karad , Prafullkumar A. Kulkarni1

1P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded (M.S.) India. 2Department of Chemistry, S.D. College, Soegaon, Aurangabad (M.S.) India. 3Department of Chemistry, M.G. College, Ahmedpur Latur (M.S.) India.

*Corresponding Author:[email protected] Abstract: Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. A simple, efficient and green protocol has been developed for the Synthesis of pyrazolo[3,4-b]quinoline derivatives from a one pot three component condensation of amino pyrazole, dimedone and different substituted aromatic aldehydes was refluxed independently in ethanol using L-Proline as a efficient and green catalyst. L- Proline can play catalytic role in the organic reactions. This methodology has number of advantages such as use of very small amount of catalyst, easy work up, short reaction times, high yields, easy access, use of non-toxic and hazardous catalyst and solvents.

Keywords: Aromatic aldehydes, Dimedone, amino pyrazole, L-Proline, green protocol etc.

PP-8

Synthesis and Evaluation of imino triazolo pyrimidine carbonitrile and its derivatives with their antioxidant activity

Navanand B. Wadwale1, Ashok R. Karad2, Gopinath S. Khansole3, Sunil S. Choudhare4, Vijay N. Bhosale*1 1P.G. Research Centre, Dept. of Chemistry, Y. M. Nanded 431 602 (M.S.) India. 2Dept. of Chemistry, M. G. M. Ahmedpur, Dist.Latur (M.S.) India. 3Dept. of Chemistry, D. A. B. N. College, Chikhali, Dist. Sangli (M.S.) India. 4Dept. of Chemistry, S.D. College, Soegaon, Dist. Aurangabad (M.S.) India.

*Corresponding Author:[email protected] Abstract: Multi-component reactions (MCRs) have emerged as an essential implement for building of diverse and complex organic molecules through carbon–carbon and carbon–heteroatom bond formations taking place in tandem manner. The 2-(bis(methylthio) methylene) malononitrile on treatment with 1H-1,2,4- triazol-3-amine in N,N-dimethyl formamide (DMF) and anhydrous potassium carbonate to form 7- imino-5-(methylthio)-1,7-dihydro-[1,2,4]triazolo[1,5-a] pyrimidine-6-carbonitrile. The formed parent compound is reacted with selected N-, O- and C-nucleophiles such as aryl amines and compounds containing active methylene compounds to form different substituted derivatives. The confirmations of the synthesized compounds were confirmed by IR, LCMS, 1HNMR and 13CNMR spectroscopic studies. Newly synthesized compounds were screened for their biological studies.

Keywords: MCR, Triazole, 2-(bis(methylthio)methylene)malononitrile, Antioxidant activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 37 Exploring New Horizons in Chemical Sciences-2019

PP-9

Microwave-assisted Solvent free one-pot three-component synthesis of novel pyrano pyrimidine trione derivatives

Vijay N. Bhosale1,*Ashok R.Karad2, Navanand B. Wadwale1, Gopinath S Khansole3, Jaman A. Angulwar4, Sunil S.Choudhare5

1P.G.Research Centre, Dept.of Chemistry, Y. M. Nanded (MS) India. 2Dept. of Chemistry, M. G. M. Ahmedpur, Latur (MS) India. 3Dept. of Chemistry, D. A. B. N. College, Chikhali, Sangli (M.S.) India. 4Department of Chemistry, D. S. C. Latur (M.S.) India. 5Dept. of Chemistry, S.D.College, Soegaon, Dist.Aurangabad (M.S.) India

*Corresponding Author: [email protected]

Abstract: Multicomponent reactions (MCRs) have been develop in recent years in form of commanding and constructive tools in synthetic organic chemistry and have paying attention because of complex molecules and drugs can be prepared from cheap and easily available starting materials. A green, mild, most efficient, eco-friendly, time saving, solvent free, simple procedure has been developed for the synthesis of pyrano [2,3-d]pyrimidine-2,4,7-triones derivatives using substituted aromatic aldehydes, barbituric acid and meldrum acid in single vessel under microwave condition using Cesium carbonate (Cs2CO3) as an efficient and mild base catalyst. Synthesized compounds were screened for their Antimicrobial activity. These newly synthesized compounds were evaluated by their spectral analysis.

Keywords: Barbituric acid, Aromatic Aldehydes, Meldrum acid, Solvent free, MCRs. .

PP- 10

Substituent Effect on the Oxidation of 2-Chloro-3-Formylquinoline by Ceric Ammonium Nitrate

Smt. Pawar S. P.*, Adhyapak M. S.*, Shioorkar M. G.*, Ubale S. B.+ *Department of Chemistry, Vivekanand College, Aurangabad +Department of Chemistry, Deogiri College, Aurangabad.

*Corresponding Author: [email protected] Abstract: The kinetic profile of oxidation of 2-chloro-3-formylquinoline by ceric ammonium nitrate can be altered by varying specific parameters. 2C3FQ and a substituent, 8-methyl-2-chloro-3-formylquinoline was synthesized by Vilsmeier-Haack cyclisation. In the kinetic study of oxidation of 2C3FQ and the substituent by C.A.N. at different temperatures the rate of oxidation was found to be enhanced in case of the substituent 8M2C3FQ as compared to that of 2C3FQ. It is therefore recommended to prefer 8M2C3FQ over 2C3FQ for enhanced efficiency in desired domain.

Keywords: Substituent, Kinetic study, 8-methyl-2-chloro-3-formylquinoline, ceric ammonium nitrate

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 38 Exploring New Horizons in Chemical Sciences-2019

PP-11

Efficient Protocol for the Synthesis of PyrazoloPyrimidines using Potassium Carbonate as Green Catalystand Its Biological Screening

Datta S. Kawale, Prashant N. Ubale and Sambhaji P. Vartale* PG Research Center, Department of Chemistry, Yeshwant Mahavidyalaya Nanded-431602 (MS) India

*Corresponding Author: [email protected]

Abstract: Pyrazole and pyrimidine derivatives attracted organic chemist due to their potent biological and chemotherapeutic significance. Pyrimidine heterocyclic core is an important scaffold because it is building block of nucleic acid. In addition to this pyrimidine ring is also present in vitamin B1andbarbituric acid. Heterocyclic fusion of two bioactive rings such as pyrimidine and pyrazole to form pyrazolopyrimidines which has high impact in the field of pharmaceutical science and shows considerable biological activities such as antibacterial, anti-inflammatory, antiasthmatic, analgesics, anticancer activity. Keeping in view of their divers biological activities, encourage us to synthesize some novel pyrazolopyrimidines. So, in present communication a new efficient method for synthesis of pyrazolopyrimidine derivatives were described by condensing 4-amino-2-phenyl-6- (methylyhio)pyrimidine -5-carbonitrile with hydrazine hydrate derivatives using potassium carbonate as catalyst. The structure of newly synthesized compounds were elucidated on the basis of IR, MASS, 1H- NMR spectroscopy. All the newly synthesized compounds were investigated for their antimicrobial activity.

PP-12

Measurement of Formaldehyde in Selected Cosmetic Products by Fast Liquid Chromatography Sushama Ambadekar1∙ Deepak Baburao Nikam2. Department of Chemistry, Institute of Science, Madam Kama Road, Fort, Mumbai 400032

*Corresponding Author: [email protected]

Abstract Fast, specific and highly sensitive High performance liquid chromatographic (HPLC) method was developed for the quantification of formaldehyde in selected cosmetic products. The sample was dissolved in selected solvent and treated with 2,4-dinitrophenylhydrazine in order that formaldehyde was derivatized to form 2,4-dinitrophenylhydrazone with high UV absorbance. The separation was carried out using C18 column. The detection wavelength was 365nm for the derivative of formaldehyde. The results showed that derivatization had no effect on the determination of formaldehyde. The limit of detection (LOD) for this method is as low as 0.006ppm and limit of quantification (LOQ) for this method is as low as 0.0125ppm. This method is successfully validated and results are obtained are positive for each parameter recommended by ICH Q2 B guidance. This method is applied for determination of formaldehyde in selected cosmetic product.

Keywords: RP-HPLC, Formaldehyde, Chromatography, Validation, ICH.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 39 Exploring New Horizons in Chemical Sciences-2019

PP- 13 Polymer Supported Reagent: Clean Oxidation of Primary Alcohols to Carbonyl compounds by kinetically Vilas Y. Sonawane

Department of Chemistry, B. Raghunath Arts, Commerce and Science College, Parbhani, 431401, Maharashtra, India

*Corresponding Author: [email protected]

Abstract: Reactive functionalized polymer has recently found wide spread applications as reactive materials in a variety of biological and technological uses based on the advantages of the functional group and the properties of the polymer molecule. The polymeric anionic oxidizing reagents are mainly based on polystyrene supported quaternary ammonium salts, polyvinyl pyridine ions; polymeric benzyl triethyammonium dichloride and dibromate are recently reported polymer-supported quaternary ammonium salts. Oxidation of alcohols to carbonyl compounds is a reaction of pre-dominant importance in synthetic organic chemistry and now considerable attention has been focused on the development of convenient and inexpensive oxidation methods without restoring to a stiochemetric amount of metal reagents such as chromic acid, potassium permanganate, periodic acid etc.In the present work done aromatic substituted primary alcohols are oxidized by using polymer supported oxidizing agent like KMnO4 ion and compare the rate of reaction kinetically.

Keywords: Polymer, Reagent, Primary alcohol, Co-oxidant

PP- 14

Microwave-assisted synthesis of some new bis-1, 3-benzoxazines and their antimicrobial activity

Avinash T. Shindea*, Nagesh J. Deshmukha, Sainath B. Zangadeb

a PG Department of Chemistry, N.E.S.Science College, Nanded (MS),India-431605 b Department of Chemistry, M.P. College, Palam, Parbhani (MS),India-431720

*Corresponding author: [email protected] Abstract: A series of bis-1, 3-benzoxazines were synthesized from reduced product of propane-1, 3-diamine Schiff bases in the presence of formalin under conventional heating and microwave irradiation. The structures of newly synthesized diamines and bis-1, 3-benzoxazines were established on the basis of spectroscopic data. Further, all the synthesized compounds were screened for antimicrobial activity. Some of the compounds showed very good activity compared to standard drugs against all pathogenic bacteria and fungi.

Keywords: Bis-schiff bases, Bis-1, 3-propane diamines, Microwave irradiation, Antimicrobial activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 40 Exploring New Horizons in Chemical Sciences-2019

PP-15 Electrochemical Detection of Paracetamol Drugs by using Ag@C60 Hybrid Nano Materials

Shankar S. Narwade and Bhaskar R. Sathe*

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad -431004 (MS) India.

*Corresponding author:[email protected]

Paracetamol, also known asacetaminophen is a medication used to treatpainandfever.It is typically used for mild to moderate pain.There is poor evidence for fever relief in children.It is often sold in combination with other ingredients such as in manycold medications.In combination withopioid pain medication, paracetamol is used for more severe pain such ascancer painand after surgery.It is typically used either by mouth or rectallybut is also availableintravenously.Paracetamol was discovered in 1877.It is the most commonly used medication for pain and fever in both the United States and Europe.

Fig.2 Electrochemical detection of Paracetamol

Novel electrocatalyst (Ag@C60) is highly sensitive, cost effective, excellent selectivity for food, pharmaceutical and clinical analysis.Those catalyst used in electrochemical activities and its size of Ag NPs decorated on Fullerene C60 10 ± 0.5 nm and C60 15 ± 2 nm. Modified 2mm dia. Modified Glassy Carbon Electrode (GCE) was investigated for paracetamol oxidation reaction.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 41 Exploring New Horizons in Chemical Sciences-2019

PP- 16 Synthesis and Antimicrobial Evaluation of Some Novel 2, 3-Dihydro-1, 5- Benzothiazepine Derivatives

1,2 Kendre M. M.* ,2S. Shah N. N. and 2Baseer M. A. 1Shri sant Gadge Maharaj Mahavidyalaya Loha, Dist. Nanded. 431708, Maharashtra, India. 2Research Chemistry Laboratory, Yeshwant Mahavidyalaya, Nanded-431602, Maharashtra, India.

*Corresponding author:[email protected] Abstract: For more than a century heterocycles have constituted one of the largest areas of research in organic synthesis. Over the last two decades, synthesis of nitrogen and sulphur containing heterocyclic compounds especially benzothiazepines retained the interest of researchers due to the unique structural properties and broad spectrum of biological activities of these compounds such as antimicrobial, anti- inflammatory, antimalarial, antioxidant and antitubercular. Benzothiazepines have their role in the treatment of cardio vascular disorders. Pharmaceuticals whose molecules contain the 1, 5- benzothiazepine moieties are widely used in medical practice. Keeping in view this broad spectrum of biological activity associated with these compounds, we have reported earlier the synthesis of some 2, 3-dihydrobenzothiazepines with dimethyl amino group substituted on ring A and halogen group substituted on ring B.

N

R2 S R3 R1 N HS 10 m mol % La(NO ) R1 3 3 N EtOH, reflux 1hr R4 H2N R2 O (1a-l) (2a-l) R3 R4 PP- 17

Au-MOPS coupled catalyst for the synthesis of 3-Amino Alkylated Indoles Suryakant Sapkal1*, Sadanand Guhe1, Sanjay Harke2, Balaji Madje3, Suchita Gadekar3

1MGM’s Jawaharlal Nehru Engineering College, Aurangabad-431 004, India, 2MGM’s Institute of Bioscience and Technology, Aurangabad-431 004, India, 4Vasantrao Naik College, Aurangabad-431 004, India. *Corresponding author:[email protected] Abstract: Gold nanoparticles (Au NPs) coupled with 3-morpholinopropane-1-sulfonic acid (MOPS) for catalytic performance to the cyclocondensation reaction of aromatic/heteroaromatic/aliphatic aldehydes, indole and aromatic/hereroaromatic amines have been demonstrated for the first time in favor of 3-amino alkylated indoles in ethyl alcohol at reflux temperature. Reaction conditions are just like ambient nevertheless all chemical transformations completed smoothly contributing worthwhile for the synthesis of 3-amino alkylated indoles. OCH HO 3

CHO NH 2 N H Au-MOPS/EtOH H Strring / Reflux H3CO N OH H N 1 2 3 4 International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 42 Exploring New Horizons in Chemical Sciences-2019

PP- 18

Synthesis of Neurokinin Substance P (+)-L-733,060

Mahendra N. Lokhande Avvaiyar Government College for Women, Karaikal Pondicherry (U.T)-609602

*Corresponding Author: [email protected]

Abstract: Enantioselective formal synthesis of Neurokinin Substance P (+)-L-733,060 was achieved using Jacobsen’s hydrolytic and Kinetic resolution strategy. Intermediate tert-butyl (2S, 3S)-3-hydroxy-2- phenylpiperidine-1-carboxylate 1has been synthesized via sequential reactions starting from cinnamyl alcohol with 10.25 % overall yield.

Keywords: Formal synthesis, Neurokinin substance, Enantioselective, Jacobsen’s hydrolytic Kinetic resolution

Boc HN N HN CF3

HN OH O CF3 1 2 3 OMe Figure 1. Non-peptidic Neurokinin NK1 receptor antagonists. PP- 19

An efficient method for the synthesis of isooxazole derivatives

Prashant M. Kulkarni, Wamanrao N. Jadhav and Sudhakar R. Bhusare* Department of Chemistry, Dnyanopasak College, Parbhani-431401, MS, India

*Corresponding Author: [email protected]

Abstract: Isoxazole is a five membered heterocyclic compound containing oxygen and nitrogen atoms in the 1, 2 positions, its partially saturated analogs are called isoxazolines and completely saturated analog is isoxazolidine. Isoxazoles are an important class of heterocycles, which are largely employed in the area of pharmaceuticals and therapeutics such as insecticidal, anti-bacterial, anti-biotic, anti-tumor, anti- fungal, anti-tuberculosis, anti-cancer and ulcerogenic. Isoxazole derivatives are used in the market as COX-2 inhibitor and anti-inflammatory drugs. With the literature survey and interest in this area we studied synthesis of isoxazoles derivatives by using nickel chloride as catalyst in solvent ethanol (Scheme 1).

R

O O O i) + ii) N Cl R Cl R O

Cl

Scheme 1 Reagents and Conditions: i) NaOH, EtOH, 2hr, RT, ii) NH2OH.HCl, NiCl2, NaOH, EtOH, RT. . International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 43 Exploring New Horizons in Chemical Sciences-2019

PP- 20

Density Functional Theory Investigation of Bond Length, Bond Angle And Thermodynamic Parameters in 4-Amino-2-Hydroxy-6-Phenylpyrimidine-5- Carboxamide A.V. Kardel1, J.S. Aher2*, M. R. Gaware3, D. D. Lokhande3

1Department of Chemistry, KGDM Arts, Commerce and Science College, Niphad, 422 303 Dist. Nashik (MS), India. 2 Department of Chemistry, K.R.T. Arts, B.H. Commerce and A.M. Science College, Shivaji Nagar, Gangapur Road Nashik 422 002, (MS), India 3 Department of Chemistry, KPG Arts, Commerce and Science College, Igatpuri, 422 402, Dist. Nashik (MS), India.

*Corresponding Author: [email protected]

Abstract: Theoretical chemistry method has been adopted to correlate the structural and electronic properties such as bond length, bond angle, Mullikan’s charges, HOMO-LUMO energy values, energy gap, dipole moment (μ), electron affinity (A), ionization potential (I), electronegativity (χ), global hardness (η), softness(σ), electrophilicity index (ω) and thermodynamic parameters using Density Functional Theory (DFT) at the B3LYP/6-311 G ++ (d, p) basis set of 4-amino-2-hydroxy-6- phenylpyrimidine-5-carboxamide.

Keywords: DFT, HOMO-LUMO, dipole moment, energy gap, thermodynamic parameter.

PP- 21

An effective organocatalytic enantioselective synthesis of 3-(α- hydroxyaryl)indoles Avinash V. Chakrawar, Shrikant S. Pendalwar and Sudhakar R. Bhusare* Department of Chemistry, Dnyanopasak College, Parbhani-431401, MS, India *Corresponding Author: [email protected] Abstract: 3-(α-hydroxyaryl) indoles are unstable towards both bases and acids, due to their propensity to go through dehydration to form stable vinylogous iminium intermediaries. This iminium genus generated in situ activates a number of chemical renovation. 3-(α-hydroxyaryl)indoles can be utilized in the synthesis of unsymmetrical bis(indolyl)alkanes, as a initiative material for obtaining prochiral compound4b and α-indolylketones. Apart from these, a few selected heteroaromatic substituted 3-(α- hydroxyaryl) indoles were reduced to their respective 3-(aryl)methylindoles that are functional in the preparation of indole alkaloids, pyridiocarbazoles, and 4-skatylpiperidines. As a result of our interest in developing new and efficient synthetic methodologies for the enantioselective synthesis of chiral organic molecules, we report herein a convenient, mild and environmentally benevolent method for the enantioselective synthesis of 3-(α-hydroxyaryl)indoles by substituted aromatic aldehydes, substituted indoles and caesium carbonate together with organocatalyst NFMPPC was stirred at room temperature in DMF as solvent for proper time (Scheme 1). HO O * R1 H i) N N H R1 H 1 2a-k 3a-k

Scheme1 Reagents and Conditions: i) NFMPPC, Cs2CO3, DMF, 30 °C.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 44 Exploring New Horizons in Chemical Sciences-2019

PP-22 Design and Synthesis of new N-bridged heterocycles as a potent Xanthine oxidase inhibitor. P. D. Gavhane*, S. N. Kadam, M. J. Hebade, S. V.Hese, B.S.Dawane*.

School of Chemical Sciences, S.R.T.M.University Nanded-431606(M.S) India.

*Corresponding Author:[email protected]

Abstract: Heterocyclic compounds with thiazolopyrimidine possess several pharmacological properties. They have been also applicable as analgesic, antiparkinsonian agents, anticancer agents, phosphate inhibitor, acetyl cholinesterase inhibitors and xanthine oxidase inhibitory activity. Considering various pharmacological applications of thiazolopyrimidine in mind we aimed to report a series of novel derivatives of 2-organosulfur substituted 5-oxo-7-(methylthio)-3-substituted phenyl-5H-thiazolo[3,2- a]pyrimidine-6-carbonitrile. All the newly synthesized compounds were confirmed by spectral analysis. All the newly formed compounds were subjected to xanthine oxidase inhibitory activity which is responsible for pathological condition gout. Some of them show good activity. .

PP- 23

A novel chromogenic spray reagent for Thin-Layer chromatographic analysis of Paraquat and design of an ultra-low-cost sensor for on-the-field detection of viologens Asif M. Pathan1, Mohammad A. Baseer2, Archana B. Kadam2 and Subhash B. Junne2* 1Regional Forensic Science Laboratory, Nanded, Maharashtra, India; 2Post graduate department of chemistry, Yeshwant Mahavidyalaya, Nanded, Maharashtra, India

*Corresponding Author:[email protected] Abstract: A novel spot test and chromogenic regent is reported for thin-layer chromatographic detection and identification of popular and highly toxic herbicide paraquat. Alkaline phenylhydrazine instantly reduces paraquat to intense purple radical cation. Surprisingly, 2,4-dinitrophenylhydrazine doesn’t show this colour test. Interaction of two drugs containing related functional groups is also studied. Based on this novel colour reaction, a simple, ultra-low-cost filter paper based sensor is also designed for direct field testing of suspicious forensic samples.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 45 Exploring New Horizons in Chemical Sciences-2019

PP- 24

Synthesis of some bioactive 4-thiazolidinone derivatives Bhaskar. S. Bhise, Sudhakar R. Bhusarea and Dinkar P. Kotwal*b a Department of Chemistry, Dnyanopasak College, Parbhani-431401 (M.S.) India. b Department of Chemistry, Dnyanopasak College, Jintur-431509 (M.S.) India.

*Corresponding Author: [email protected]

Abstract: 4-Thiazolidine derivatives are an important class of heterocyclic compounds known for their potential pharmaceutical applications. Recently, this framework containing compounds were effective against antimicrobial, antischistosomal activity, antifungal, antiinflammatory , antimalarial, herbicidal, antiviral, antidiabetic and antioxidant activities. In the present work we synthesized Schiff bases from aromatic carbonyl compounds followed by cyclisation with thioglycolic acid to produce 4-thiazolidinone heterocyclic compounds (Scheme 1).

R" S O R" O NH2 N R"

i) ii) R' + R' R R' R R

Scheme 1 Reagent and Conditions: i) Solvent ii) Thioglycolic Acid PP- 25 Facile and Efficient Synthesis β-Lactum Derivatives via Schiff’s Bases Manoj S. More and Sudhakar R. Bhusare* Department of Chemistry, Dnyanopasak College, Parbhani-431401 (MS) India

*Corresponding Author: [email protected] Abstract: Natural and synthetic azetidinone derivatives occupy a central place among medicinally important compounds due to their diverse and interesting antibiotic activities. The utility of azetidinones as synthons for various biologically active compounds, as well as their recognition as cholesterol absorption inhibitors and enzyme inhibitors has given impetus to these studies. Synthesis of the β-lactum (azetidin-2-one) derivatives involve the synthesis of Schiff’s base followed by cyclization with ketene, which produced by reacting triethyl amine with the acetyl chloride in situ. In this present study a series of β-lactum (azetidin-2-one) derivatives were synthesized with excellent yields Scheme 1. O

N NH2 CHO N

i) R' ii) R +

R R' R

R'

Scheme 1 Reagent and Condition: i) Solvent, r. t, ii) Acetyl Chloride & TEA.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 46 Exploring New Horizons in Chemical Sciences-2019

PP-26

Ionic liquid catalyzed a facile three component one-pot synthesis of 3, 4, 6- triarylpyridazines Madhavi S. Menkudle, Wamanrao N. Jadhav and Sudhakar R. Bhusare* Department of Chemistry, Dnyanopasak College, Parbhani-431401, MS, India *Corresponding Author: [email protected] Abstract: Pyridazines are structurally important moiety in several biologically active and medicinally potent. Pyridazine and its derivatives continue to attract a great deal of attention due to their wide occurrence in natural products. The pyridazine nucleus is an integral to several medicinally useful drugs such as analgesics, antibacterial, antidepressant, and anti-diabetic drugs. Agricultural science takes advantage of their high biological activity in the preparation of potent insecticides, fungicides, cardiotonics and bacteriocides. Also, new methods of synthesis of various pyridazines with the unique structural features have been already reported and reviewed. As interest in the development for the synthesis of heterocycles using ionic liquid as a catalyst, herein we describe an efficient synthesis of 3,4,6-triarylpyridazines starting from benzil, various aromatic acetophenone and hydrazine hydrate using [Hmim]HSO4 as a catalyst at ambient temperature condition (Scheme 1).

COCH3 O N i) N Ph + R Ph + NH2NH2. H2O Ph O R 1 2a-j 3 4a-j Ph

Scheme 1 Reagent and Condition: i) [Hmim]HSO4, EtOH, RT. PP- 27 A Convenient One-Pot Four Component Synthesis of 1H-Pyrazolo[1,2-b]phthalazine- 5,10-diones catalyzed by Nickel Nitrate Santosh V. Goswami and Sudhakar R. Bhusare* Department of Chemistry, Dnyanopasak College, Parbhani-431401, MS, India *Corresponding Author:[email protected] Abstract: Nitrogen-containing heterocyclic compounds are widespread in nature, & their applications in biologically active pharmaceuticals, agrochemicals, and functional materials are getting more and important.Furthermore pyrazoles are usually the core fragment of many biologically active compounds, such as Celecoxib, Viagra, Pyrazofurine, and so on. Recently, heterocycles containing a phthalazine moiety have attracted extensive attentions. Phthalazine derivatives have been reported to possess anticonvulsant, cardiotonic, vasorelaxant, cytotoxic antimicrobial, antifungal, anticancer and anti- inflammatory activities. In addition, the titled compounds, pyrazolo[1,2-b]phthalazine-diones, were also found to have analgesic, antihypoxic, and anti-pyretic activities. The development of simple methods for the synthesis of pyrazolo[1,2-b]phthalazine-5,10-diones is very important. Herein we wish to report the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives by a one-pot 4-component condensation reaction of phthalimide, hydrazine hydrate, aromatic aldehydes & malononitrile or ethyl cyanoacetate catalyzed by Lewis acid nickel nitrate in solvent ethanol (Scheme 1). R

O CHO O X i) N NH + NH2NH2.H2O + + X N CN R O 1 2 3 4a-j O 5a-j NH2 Scheme 1 Reagents and Conditions: Nickel nitrate (10 mol%), EtOH, Reflux.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 47 Exploring New Horizons in Chemical Sciences-2019

PP-28

An efficient synthesis of trisubstituted quinolines using ammonium metavanadate as a catalyst

Sharad S. Idhole and Sudhakar R. Bhusare* Department of Chemistry, Dnyanopasak College, Parbhani-431401, MS, India

*Corresponding Author: [email protected] Abstract: Quinoline and their derivatives are receiving increasing importance due to their wide range of biological activities as anti-malarial, anti-bacterial, anti-asthmatic, anti-hypertensive, anti-inflammatory, anti- platelet activity and as tyro-kinase PDGF-RTK inhibiting activity. In addition, quinoline has also been employed in the study of bio-organic and bio-organometallic processes. Due to such a wide range of applicability in medicinal, bioorganic, industrial as well as in the fields of synthetic organic chemistry, there has been increasing interest in the development of efficient methodologies for the synthesis of quinolines. Herein we wish to report a highly efficient and environmentally benign protocol for the synthesis of 2,4,6-trisubstituted quinolines using ammonium metavanadate as catalyst (Scheme 1). O CH3 O X O O X CH3 i) R + H3C R NH2 N CH3 X = H, Cl

Scheme 1 Reagents and Conditions: NH4VO3 (10 mol %), EtOH, RT. PP- 29

[Hmim]HSO4 catalyzed an effective synthesis of quinazoline derivatives Suresh C Jadhavar,a Madhukar S. Gaikwad,a Anil S. Kirdantb and Sudhakar R. Bhusarec*

aDepartment of Chemistry, Yogeshwari Mahavidyalaya, Ambajogai, MS, India. bDepartment of Chemistry, Vasant Mahavidyalaya, Kaij, MS, India. cDepartment of Chemistry, Dnyanopasak College, Parbhani, MS, India

*Corresponding Author: [email protected] Abstract: The quinazoline moiety generally exists in a variety of naturally occurring alkaloids presenting a broad range of the biological activities. Quinazolines retains an important place in synthetic organic chemistry for their significant appliances in clinical, chemical and biological area. Medicinally quinazoline has been applied in numerous areas as an anti-oxidant, analgesic, anti-inflammatory, anti-cancer, anti- bacterial, anti-convulsant, anti-mycobacterial and anti-fungal agents. It has also been found in the cure of malaria. Owing to the availability of quinazoline moiety in lots of naturally occurring alkaloids, it has a huge significance to chemists and biologists. In continuation of our interest on MCRs, herein we have developed an useful approach for the synthesis of quinazoline derivatives with excellent yields using ionic liquid [Hmim]HSO4 as a catalyst (Scheme 1). CH3 COCH3 CHO [Hmim]HSO4 N OH + + NH4OAc MeCN, 50 oC Cl OH R1 N R1 1 2a-j 3 4a-j Scheme 1 International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 48 Exploring New Horizons in Chemical Sciences-2019

PP-30

Synthesis of 훃-amino ketones by Mannich reaction using Ionic liquids containing carboxyl functional group in aqueous media.

Balaji D. Kokane Department of Chemistry, Shri Kumarswami Mahavidyalaya, Ausa Dist. Latur (M.S.) 413520.

*Corresponding Author:[email protected] Abstract: Homogeneous catalysts gives us better selectivity, efficiency and results under the mild conditions.But the in homogeneous catalysis recovery of catalyst is difficult. In heterogeneous catalysis the problem of recovery of catalyst is not created. However researcher requires both the catalytic condition so we need to develop such catalyst that can work in homogeneous and heterogeneous catalytic condition we named this new suitable catalyst as ‘functionalized ionic liquids.’ In the present study synthesis of β-amino ketones was carried out by Mannich reaction using ionic liquids containing carboxyl functional group in aqueous media.

PP- 31

Biobased, Nano formulations of nonedible vegetable oils for pesticidal applications

Kartiki Jadhav

Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai-400019

*Corresponding Author: [email protected]

Abstract: The field of emulsion technology is expanding rapidly and offers distinct possibilies of meeting the various needs of day today life. Surfactant plays a key role in stabilizing these emulsions.Most of these formulations are stabilized by using either ionic or nonionic surfactants. If these surfactants are not biodegradable then they pose severe problems to the environment. Biobased surfactants can replace them partially and reduce the problem to some extent.Soapnut (reetha) and Balanitse Aegyptia (hingot) used as natural surfactant for emulsion formation with nonedible oils such as Neem oil, Karanja oil and Castor oil. The proposed study would lead to cheaper, simple and feasible optimized process of emulsification of nonedible vegetable oils using biosurfactant.This process would produce natural products with enhanced application characteristics.The obtained formulations will be used as agrochemical which will overcome the problems associated with the conventional equivalent products having synthetic excipients.

Keywords: Surfactants, Nonedible oils, Pesticides.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 49 Exploring New Horizons in Chemical Sciences-2019

PP- 32

Effect of pH on soil quality and productivity

Nana Sahebrao Mirgea, Digambar D. Gaikwadb

aAssistant. Professor, Dept. of Chemistry National Collage, Bharadi, Tq. Sillod, Dist. Aurangabad 431113, India bDepartmentof Chemistry Govt. Arts & Science Collage, Aurangabad, Pin code, India

*Corresponding Author: [email protected]

Abstract: The most important property of soil as related to plant nutrition is its hydrogen ion activity, or pH (the term "reaction" is also used, especially in older literature). Soil reaction is intimately associated with most soil-plant relations. To collect soil sample from different selected placeless in different season, to know the pH of different collected soil. To check the effect of pH on quality of Macronutrient in soil. To suggest reliable remedies to the farmers, Different type of quality soil will available at different places. There will be variation in pH of in different soil.Variation in pH will be affect on the macronutrient in soil.

PP-33

Peel Extract Associated Oxidative Green Dakin Synthesis of some Phenols using Water Extract of Banana (WEB) as a Catalyst

a a a b Ishwari A. Kale , Aniket P. Sarkate , Kshipra S. Karnik , Pravin S. Wakte, Bhagwan K. Sakhalea, Dattatraya N. Pansareb

aDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, MS, India. bDepartment of Chemistry, Deogiri college, Station road, Aurangabad-431005, MS, India.

*Corresponding Author:[email protected] Abstract: The green Dakin reactions can be performed by employing the gallic acid as an oxidizing agent. Implementation of gallic acid helps to avoid the usage of catalyst, ligand and any toxic or hazardous oxidizing agent. Gallic acid accelerates the conversion of the atmospheric oxygen into hydrogen peroxide, which helps in the oxidation of aldehydes in situ. Mango peel, potato peel, pomegranate pomace, grape pomace extract contains the rich source of gallic acid that performs the oxidations in a natural feedstock. The best results were obtained by mango peel as well as potato peel extract giving excellent yields with minimum time at room temperature. The ‘Water Extract of Banana’ (WEB), in the said conversion plays a dual role of catalyst and a base. The reported work can be considered as environmental friendly Dakin oxidation, as it is carried out in neat WEB at room temperature under aerobic conditions with low reaction time and better yield.

Keywords: Dakin reaction, Gallic acid, Water extract of Banana, Mango peel, Potato peel, Pomegranate pomace, Grape pomace.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 50 Exploring New Horizons in Chemical Sciences-2019

PP- 34

Synthesis of 2-((5-benzylidene-4-oxo-4, 5-dihydrothiazol-2-yl)-amino) acid and its derivatives as anticancer and antimicrobial agents

Rohini N. Shelkea · Dattatraya N. Pansareb*· Chandraknat D. Pawarc · Satish U. Deshmukhb · Aniket P. Sarkatec · Rajendra P. Pawarb · Nileema S. Goree · Devanand B. Shinded · Shankar R. Thopatea

aDepartment of Chemistry, Prof. John Barnabas Post Graduate School of Biological Studies, Ahmednagar College, Ahmednagar-414001, MS, India bDepartment of Chemistry, Deogiri college, Station road, Aurangabad-431 005, MS, India. cDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, MS, India. dShivaji University, Vidyanagar, Kolhapur- 416 004, MS, India. eMGM’s Institute of Biosciences & Technology, N-6, Cidco, Aurangabad-431003, MS, India.

*Corresponding Author: [email protected] Abstract: A series of rhodanine derivatives 3, 4 and 6(a-l) were synthesized by knoevenagel condensation. All the synthesized compounds were also tested for their in vitro anticancer activity against MCF-7 and BT-474 human breast cancer cell lines. All the synthesized compounds were characterized and screened for their antimicrobial activity against bacterial and fungal strain. Majority of the compounds showed good to moderate anticancer and antimicrobial activity. Among these compounds 6j showed promising activity against gram-positive bacteria B. subtilis and S. aureus when compared with ampicillin. Some of the most potent compounds, namely 6g, 6h and 6j possessed selective antimicrobial activity.

Keywords: 2-Thioxothiazolidin-4-One; Knoevenagel Condensation; Anticancer Activity; Antimicrobial Activity. PP- 35 Thionyl chloride catalyzed convenient synthesis of some novel benzamides from benzoic acid and amines under solvent free conditions Shritesh D. Jagtapa, Aniket P. Sarkatea, Ishudeep K. Narula,a Kshipra S. Karnika, Dattatraya N. Pansareb aDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, (MS), India. bDepartment of Chemistry, Deogiri college, Station road, Aurangabad 431 005, MS, India. *Corresponding Author:[email protected]

Abstract A new method of thionyl chloride catalyzed synthesis of novel benzamides under solvent free conditions has been developed using benzoic acid and amines. The benzamides were synthesized through a coupling reaction of benzoic acid and different amines using thionyl chloride at room temperature. The above mentioned technique helped in the preparation of substituted benzamides which were obtained in good yields within 2-4 h using conventional heating. Also the above method is ligand free. The developed method is flexible, economic, having minimum environmental impact; also are catalyst, ligand and solvent free and has major importance in industry and laboratory.

Keywords: Thionyl chloride, Coupling reaction, Benzamides, Benzoic acid, Conventional heating, ligand free, solvent free.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 51 Exploring New Horizons in Chemical Sciences-2019

PP- 36

Catalyst Free Convenient Synthesis of Some Substituted Pyridine Benzamides from Aryl Aldehydes

Vaishnavi S. Jambhorkara, Aniket P. Sarkate,a Aishwarya P. Rajhans,a Kshipra S. Karnik,a Sajed H. Ansari,a Shambala U. Chavan,a Dattatraya N. Pansareb

aDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, (MS), India. bDepartment of Chemistry, Deogiri college, Station road, Aurangabad 431 005, MS, India.

*Corresponding Author: [email protected] Abstract: A new method of amides synthesis under catalyst free condition has been developed by using aldehydes and aminopyridine. The amides were synthesized by using different aldeydes and aminopyridine using ethanol as a solvent and hydrogen peroxide as oxidant. The mentioned method helps in preparation of amides which were acquired in good yield within 4-5 h using conventional heating. The reported reaction is catalyst free. The developed method is easy, economic and flexible having marked importance in industry and laboratory.

Keywords: Ethanol, Benzamide, Aldehyde, Aminopyridine, Conventional Heating, Hydrogen Peroxide, Catalyst Free.

PP- 37

Simple chromium catalyzed oxidative synthesis of Quinazolinones and Benzoxazinones from 2-aminobenzamide and anthranilic acid with arylaldehydes a a a b Ashwini V. Izankar , Kshipra S. Karnik , Aniket P. Sarkate, Pramod S. Patil, Dattatraya N. Pansarec

aDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, (MS), India. bDepartment of Physics, School of Nanoscience and Technology, Shivaji University, Vidyanagar, Kolhapur-416004, MS, India. cDepartment of Chemistry, Deogiri college, Station road, Aurangabad 431 005, MS, India.

*Corresponding Author: [email protected] Abstract: An easy and efficient protocol for oxidative synthesis of quinazolinones and benzoxazinones using novel catalyst chromium trioxide has been developed. Here chromium trioxide acts as a catalyst as well as an oxidant. Newly developed method demonstrates a new alternative to existing method which is a cost effective approach to synthesize important moieties like quinazolinones and benzoxazinones from easily available starting materials in good to excellent yields.

Keywords: Quinazolinones; Benzoxazinones; Chromium Trioxide; Catalyst; Oxidant.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 52 Exploring New Horizons in Chemical Sciences-2019

PP- 38

One-Pot synthesis of coumarine under green approach using ferrous sulphate as catalyst

Gurumeet C Wadhawa,1 Dattatraya N. Pansare,2 Harshada Deshmukh,1 Vitthal S. Shivankar,1 Yashwant A Gaikwad1

1Assistant Professor at Post Graduate Department of Chemistry, Karmaveer Bhaurao Patil College Vashi sector 15 A Navi Mumbai, 400703, Maharashtra, India. 2Department of Chemistry, Deogiri college, Station road, Aurangabad 431 005, MS, India.

*Corresponding Author: [email protected]

Abstract: Synthesis of various substituted coumarins from substituted phenol and β-ketoester (Ethyl Acetoacetate) via Pechmann condensation using heterogeneous catalyst like red mud solvent free condition under sonication. Reaction required low reaction time, very mild reaction condition, at room temperature and easy workup with good yield of the product.

Keywords: Coumarins, Pechmann condensation, Solvent free reaction, sonication

PP- 39

Synthesis and Biological Evaluation of New Schiff’s Bases as Anti-infective Drugs

Pawan Suryakant Hardas, Mahadev Gangaram Landge and Babasaheb Vaijnath Kendre*

Department of Chemistry, Vaidyanath College, Parli-Vaijnath Dist. Beed (MS) India

*Corresponding Author: [email protected]

Abstract: An efficient synthesis of novel Schiff’s bases 3a-l containing aryl sulfonamide functionality has been carried out by the condensation reaction of chromenes 1 with 2-amino-1, 3, 4 oxadiazole and 2-amino-1, 3, 4 thiadiazole 2 in methanol under reflux conditions for 1-2h. Synthesized compounds were tested for their antimicrobial activities and a few of them have displayed potent anti bacterial and anti-fungal activities.

Key words: Sulfonamide, Oxadiazole, Thiadiazole, Chromene

N N R CHO N N R i + N X TsHN O O X 1 H2N 2 TsHN O O 3a-l X = O, S

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 53 Exploring New Horizons in Chemical Sciences-2019

PP- 40

Absorption spectra of rhodamine-6 G in aqueous electrolyte solution.

Pandurang D. Talap

Department of Chemistry Govt. Arts & Science Collage, Aurangabad, Pin code, India

*Corresponding Author: [email protected]

Abstract: The self-aggregation of rhodamine–6G [1*10-6 to 4*10-4] in water and in aqueous solution of LiCl, NaCl, KCl, [0.1 M, 0.3 M, 0.5 M, 0.7 M] has been investigated by recording electronic spectra in the wavelength range 460-600 nm. Analysis of the spectral data yielded the dimer dissociation constant individual characteristics monomer and dimer spectra. By applying the excitation model for the first time, the interaction energy between the rhodamine–6G molecules in dimer species has been evaluated. Further, information about the dimer geometry twist angle between the dipoles of the Rh-6G molecule has been obtained.

PP- 41 Ultrasound Promoted One-pot Synthesis of Substituted Pyrazoles Using Glyoxylic Acid as a Catalyst under Solvent-free Condition

Chandrashekhar G. Devkate*1, Ajay M. Patil2, Digambar D. Gaikwad3, Mohammad Idrees M. Siddique4

*1Dept. of Chemistry, Indraraj Arts, Commerce and Science College, Sillod, Aurangabad-431112 2Dept. of Chemistry, Pratishthan Arts, Comm. and Science College, Paithan, Aurangabad-431107 3Dept. of Chemistry, Govt. College of Arts and Science, Aurangabad-431001 4Dept. of chemistry, Government Institute of Science, Nagpur-440008

*Corresponding Author:[email protected]

Abstract: Synthesis of substituted pyrazoles by one pot condensation reaction of substituted cinnamaldehydes and tosylhydrazine in the presence of glyoxy;ic acid under solvent free condition. The methodology highlights the use of ultrasonic irradiation as non conventional sources. The catalyst used is readily available and cost effective which makes the method more green and efficient.

Key words: 3-Substituted pyrazole, Glyoxylic acid, Ultrasound irradiation.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 54 Exploring New Horizons in Chemical Sciences-2019

PP-42

Synthesis and various biological activities of tetrahydroquinoline, and pyrimidine derivatives Pravin N. Chavan1*, Dattatraya N. Pansare2, Shivaji L. Jadhav3, Megha J. Rai4

1Department of Chemistry, Doshi Vakil College, Goregaon, District-Raigad, (MS), India. 2Department of Chemistry, Deogiri College, Station road Aurangabad, (MS), India. 3Department of Chemistry, Tarai College, Paithan, Aurangabad, (MS), India. 4Department of Chemistry, Dr. Rafiq Zakaria College for Woman, Aurangabad, (MS), India.

Corresponding Author: [email protected], [email protected]

Abstract: A series of new tetrahydroquinoline derivatives (4a-j) were prepared by one pot multicomponent, (4+2) cycloaddition route from 4- amino naphthalene, aromatic aldehydes, DHF by using InCl3 catalyst under reflux temperature and also, pyrimidine derivatives (4a-n) were prepared by same route from Benzamidazole, aromatic aldehydes, maleic anhydride by using piperidine catalyst under ultrasonic irradiations. The synthesized tetrahydroquinoline and pyrimidine derivatives were characterized (IR, 1H NMR, 13C NMR). The synthesized tetrahydroquinoline and pyrimidine derivatives have been evaluated for antimicrobial, anti-tuberculosis and anti- inflammatory activities.

Keywords: Tetrahydroquinoline; Pyrimidine; Biological Activity.

PP- 43

Synthesis and anticancer evaluation of benzenesulfonamide derivatives Rohini N. Shelkea · Dattatraya N. Pansareb*· Chandraknat D. Pawarc · Satish U. Deshmukhb · Pravin N. Chavand · Rajendra P. Pawarb · Shankar R. Thopatea

aDepartment of Chemistry, Prof. John Barnabas Post Graduate School of Biological Studies, Ahmednagar College, Ahmednagar-414001, MS, India bDepartment of Chemistry, Deogiri college, Station road, Aurangabad-431 005, MS, India. cDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, MS, India. dDepartment of Chemistry, Doshi Vakil College, Goregaon, District-Raigad, (MS), India.

*Corresponding Author: [email protected]

Abstract: A highly efficient protocol was developed for the synthesis of Synthesis of 3-(indoline-1-carbonyl)-N- (substituted) benzene sulfonamide analogues with excellent yields. The new 3-(indoline-1-carbonyl)-N- (substituted) benzene sulfonamide derivatives (4a-g and 5a-g) were evaluated in vitro anticancer activity against a series of different cell lines like A549 (Lung Cancer cell), HeLa (Cervical), MCF-7 (Breast Cancer cell) and Du-145 (Prostate Cancer cell) respectively. The results of the anticancer activity data revealed that most of the tested compounds showed IC50 values from 1.98-9.12 µM in different cell lines. Compounds 4b, 4d, 5d and 5g were the most potent, with IC50 values ranging from 1.98-2.72 µM. in different cell lines.

Keywords: Indoline, Sulfonamide, Anticancer.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 55 Exploring New Horizons in Chemical Sciences-2019

PP- 44

L-pyrrolidine-2-carboxylic acid sulfate: A new ionic liquid for the synthesis of bioactive 3, 4-Dihydropyrano[c]chromenederivatives

V. W. Godsea, S. S. Rindhea, A. E. Atharea, B. H. Zawarea, P. Y. Pawarc and Rajendra P. Pawarb* aDepartment of Chemistry, NACS College, Ahmednagar, 414001, Maharashtra, India. bDepartment of Chemistry, Deogiri College, Aurangabad, 431005, Maharashtra, India. cDepartment of Pharmaceutical Chemistry, Pad. Dr. V. V. P. Foundation’s, College of Pharmacy, Ahmednagar, 414001, Maharashtra, India.

*Corresponding Author: [email protected], [email protected]

Abstract: A Clean, simple and highly efficient protocol for the synthesis of 3, 4-Dihydropyrano[c]chromene derivatives utilizing novel bronsted acidic ionic liquid; L-Pyrrolidine-2-carboxylic acid sulfate (LPCAS) as a catalyst has been reported. Distinguishing features of the methodology are excellent yield of products in shorter reaction time, cleaner reaction profile, environmentally friendly nature and the use of inexpensive catalyst.

R

O O OH LPCAS R CN CN H water + + O o CN 100 C O O O NH 10-30 min 2

PP- 45 Synthesis of Highly Substituted Furan catalyzed by NBS

Gangadhar. B. Gundlewad,1* Bhagwan. R. Patil,2 Vikas V Borgaonkar3 1Department of Chemistry, Shri Shivaji College, Parbhani, 431401, Maharashtra. 2Department of Chemistry, Sharda Mahavidyalaya, Parbhani, 431401, Maharashtra. 2Department of Chemistry, Shri Siddheshwar Mahavidyalaya, Majlgaon, 431131, Mharashtra

*Corresponding Author: [email protected] Abstract A series of 5-aryl-2-methylfuran-3-carboxylate were synthesized by one pot reaction of ethyl aceto- acetate and α-chloroacetophenone in presence of NBS. These compounds were characterized by IR, 1HNMR & Mass Spectral data and elemental analysis.

OC2H5 R1 O R OC2H5 1 R2 R2 Cl O NBS + i-Pr-OH O O R3 R3

R4 1a-f 2 3a-f R4

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 56 Exploring New Horizons in Chemical Sciences-2019

PP- 46

Enantioselective synthesis of Cytotoxic and Topoisomerase-II inhibitor Deoxythysanone, catalyzed by chiral spiroborate ester

Manojkumar U. Chopadea,b*, Milind D. Nikaljeb, Anil U. Chopade,

a SantDnyaneshwarMahavidyalaya, Department of Chemistry, Soegaon, Dist: Aurangabad, b Department of Chemistry, Savitribai Phule University, Pune, cDahiwadi College, Dahiwadi, Rayat Shikshan Sansthan, Satara, Shivaji University Kolhapur 415508,

*Corresponding Author: [email protected]

Abstract: Pyranonaphthoquinone bioactive analogous (1R,3S)-Deoxythysanone, (1R,3S)-Thysanone and (1R,3S)- Demethoxythysanone are efficiently synthesized from common intermediate (S)-3-methyl-3,4-dihydro- 1H-isochromene-5,8-dione. We developed pyranonaphthoquinones antibiotics short synthetic route, which involve enantioselective reduction of homobenzylic ketone by chiral spiroborate catalyst with 87% enantiomeric excess as a key step. Further Oxa-Pectet-Spengler reaction followed by oxidative demethylation to furnish Deoxythysanone.

Keywords: Homobenzylic Ketone; Spiroborate esters; Asymmetric Reduction; Alcohol; Deoxythysanone

PP-47

pH-metric study of metal-ligand stability constant of transition metal complexes with pharmacologically active ligand N, -[(E)-(4-Hydroxy- 3methoxyphenyl)methylene]isonicotinohydrazide

Zamzam Taher Omar (Al-Ahdal), Shivaji Jadhav, Megha Rai*

Department of Chemistry, Dr.Rafiq Zakaria College for Women, Aurangabad - 431001, MS, India.

*Corresponding Author: [email protected], [email protected] Abstract: The interaction of Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) metal ions with organic ligand (Schiff base) N, -[(E)-(4-Hydroxy-3methoxyphenyl)methylene]isonicotinohydrazide have been studied by pH- 0 metric technique at 27±1 C in 70%(v/v) ethanol - water medium at 1M (NaClO4) ionic strength. Organic ligand (Schiff base) was synthesized by condensation of equimolar mixture of Anti- mycobacterial agent (nicotinohydrazide) with aromatic aldehyde. The reaction progress and purity of organic ligands were confirmed by thin layer chromatography. Formation of organic ligands was confirmed with the help of MP, IR, 1H NMR, 13C NMR and elemental analysis. The stability constants of these binary complexes were evaluated and order of stability constant found as Cu (II) > Co (II) > Mn (II) > Ni (II) > Zn (II).

Keywords: Ph-Metric Technique, Binary Complexation, N,-[(E)-(4-Hydroxy- 3methoxyphenyl)Methylene]Isonicotinohydrazide, Transition Metals.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 57 Exploring New Horizons in Chemical Sciences-2019

PP-48

Biological Significance of Pyrimidine Derivatives: Review

Abhay Bagul1, D.D. Gaikwad2, Sanjay Karjodkar3, Vikarm Vichare4

1Departmentof Chemistry, Govt. College of Arts and Science, Aurangabad, 431004, India 1Departmentof Chemistry, Vasntatrao Naik Mahavidyalay, Aurangabad, 431003, India

*Corresponding Author: [email protected] Abstract: Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six-member ring show wide range of biological activities. In recent decades, numerous methods for the synthesis of pyrimidine and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Pyrimidine possess wide spectrum of biological activities including anti- inflammatory, antifungal, antibacterial, antioxidant, anticonvulsant, antitubercular, antiviral, antimalarial, anticancer, anti-HIV, analgesic activity. This article aims to review the recent works on pyrimidine derivatives together with the biological potential during the past years.

Keywords: Pyrimidine, Synthesis, Biological activities.

PP-49

One-Pot Three Components Synthesis of Pyrazolo[3, 4-b] Quinoline Derivatives Catalysed By DBU

1 2 1 3 Vijay N. Bhosale* , Sunil S. Choudhare , Navanand B.Wadwale , Ashok R. Karad , Prafullkumar A. Kulkarni1

1.P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded (M.S.) India. 2. Department of Chemistry, S.D. College, Soegaon, Aurangabad (M.S.) India. 3. Department of Chemistry, M.G. College, Ahmedpur Latur (M.S.) India.

*Corresponding author:[email protected]

Abstract: Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. A simple, efficient and green protocol has been developed for the Synthesis of pyrazolo[3,4-b]quinoline derivatives from a one pot three component condensation of methyl-1H-pyrazol-5-amine, dimedone and different substituted aromatic aldehydes was refluxed independently in ethanol using 1, 8-diazabicyclo [5.4.0] undec-7-ene (DBU) as a efficient and green catalyst. DBU can play catalytic role in the organic reactions. This methodology has number of advantages such as: use of very small amount of catalyst, easy work up, short reaction times, high yields, easy access, use of non-toxic and hazardous catalyst and solvents.

Keywords: Aromatic aldehydes, Dimedone, methyl-1H-pyrazol-5-amine, DBU, green protocol etc.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 58 Exploring New Horizons in Chemical Sciences-2019

PP-50

Impact of industrial waste on water quality around Mahad MIDC area district Raigad Maharashtra

1Srikant Kekane, 2Dr. R P Chavan 1Department of chemistry I. C. S. College, Khed (Maharastra) India. 2Department of chemistry Dnyanasadhana College, Thane west (Maharastra) India.

*Corresponding Author: [email protected] Abstract: Most recently, there have been a growing number of publications focusing on water pollution, considering this the assessment of ground water quality of Mahad M.I.D.C. industrial area carried out. Water around this area is utilized for domestic and drinking purpose and therefore it is important to assess the quality of water. The mass industrialization and the rising urbanization are key reasons for the abrupt increasing pollution of water. Therefore, focusing this issue, the present study aims to validate the water pollution due to heavy metals. The samples of water were collected from wells and revers around the industrial area at each month throughout the year. The heavy metals namely iron, copper, zinc, manganese, nickel, chromium, cobalt and lead were determined by using Atomic Absorption Spectrophotometer. The evidence from this study suggests that, the few of the heavy metal concentration in this area is increasing unexpectedly.

Keywords: Water, heavy metal, Pollution.

PP- 51 A novel Schiff base of 3-formyl-6-methylchromone and 3-aminoquinoline and its Cu(II) and Co(II) complexes: Synthesis, Characterization and Antimicrobial screening studies

Sushil K. Ghumbre1,*, Atul S. Renge2, Bhimrao C. Khade3

1Department of Chemistry, I.C.S. College of Art’s, Commerce and Science, Khed-415 709, INDIA 2Department of Chemistry, Konkan Gyanpeet Karjat College of A.S.C., Karjat, INDIA 3Department of Chemistry, Dnyanopasak College of Art’s, Commerce & Science, Parbhani-431 401, INDIA

*Corresponding Author: [email protected] Abstract: A novel Schiff base 6-methyl-3-((quinolin-3-ylimno) methyl)-4H-chromen-4-one obtained by the condensation of 3-formyl-6-methylchromone and 3-aminoquinoline and synthesis of its Cu(II) and Co(II) complexes. Schiff base and its complexes have been characterized by analytical data, elemental analysis, molar conductance, magnetic moment and thermogravimetric analysis. The structural elucidation of prepared compounds carried out by UV-Visible, infrared 1HNMR spectroscopic techniques. The elemental analysis revealed metal to ligand stoichiometry was 1:2. Spectroscopic studies and magnetic moment data interpret octahedral geometry of the complexes. The measured low molar conductance values in DMF indicate that complexes are non-electrolyte. The synthesized compounds were evaluated by in vitro antimicrobial analysis and results were compared with standard tetracycline. Schiff base and its metal complexes shown remarkable antibacterial and antifungal activity.

Keywords: Schiff base, Antimicrobial activity, 3-Aminoquinoline, 3-Formyl-6-methylchromone.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 59 Exploring New Horizons in Chemical Sciences-2019

PP-52 Ionic Liquid Assisted Synthesis of Benzylidene-1, 3-thiazolidine-2, 4-diones

Sharad K. Awatea, Sandeep B Kotwalb, Prajakta S Moreb andPrashant B. Thorat*b

a Department of Chemistry, S.I.C.E.S. College, Ambarnath Thane 421505, MS, India b Department of Chemistry, Smt. C. H. M. College, Ulhasnagar, Thane, 421003 MS India *Corresponding Author: [email protected]

Abstract: Thiazolidinedione acts as significant heterocyclic ring system for manydrugs and a privileged scaffold in medicinal chemistry.The activity of thiazolidinediones can be tuned by variable substitutions at 3 and 5 positions, but greatest change in structure and properties is possible by substitution at position 2. Owing to its wild and flexible nature, thiazolidinedionesand its derivatives are found to have extensiverange of pharmacological activities such as antihyperglycemic,antimicrobial, antiviral, antioxidant, aldose reductase inhibitors, anticancer, anti-inflammatory,anti-plasmodial, COX inhibitors, PPARg agonists/modulatorsand many more. Literature reveals thatvarious efforts have been going on worldwide to determine vast biological profile of thiazolidinediones. Because of unique properties of IL, such as non-infammability, low volatility, negligible vapour pressure, reusability and high thermal stability the have been used employed as solvent / catalysts. Ionic liquidimidazoliumcations are the effective powerful reaction media at room temperature and can be easily synthesized. These ionic liquids also act as catalysts showing good performance in many reactions. In present work, our recent interest has been in the development of new synthetic methods using ionic liquids as reaction media for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2- thioxothiazolidin-4-one derivatives. O O CHO HN [Bmim][BF4] + NH RT, 8-10 h S S R X N(Et)3 R O

Scheme 1: Synthesis of Benzylidene-1, 3-thiazolidine-2, 4-diones PP- 53 Kinetics and Mechanism of Oxidation of L-isoleucine by Tributylammonium Chlorochromate in acetic acid medium Prabhakar Kute1 Nandkishor Chaudhari* 1Department of Chemistry, Pratishthan Mahavidyalaya Paithan, Aurangabad - 431107 (M.S) India. *Department of Physics, Pratishthan Mahavidyalaya Paithan, Aurangabad - 431107 (M.S) India.

*Corresponding Author: [email protected], *[email protected]

Abstract: Kinetics and Mechanism of Oxidation of L-isoleucine (Ile) by Tributylammonium Chlorochromate in acetic acid medium were studied spectrophotometrically at 445 nm. The reaction is first order with respect to both oxidant and substrate and positive fractional order with respect to H+. The reaction between isoleucine and oxidant in acid medium exhibit 1:1 stoichiometry. By changing the salts had no significant effect on the rate of reaction. The reaction was studied at different temperatures and the activation parameters were calculated. The main product was identified as the corresponding carbonyl compound by spot test. A plausible mechanism was proposed to explain the results of kinetic studies, reaction stoichiometry and product analysis.

Keywords: Kinetics, Tributylammonium chlorochromate, Isoleucine, Oxidation.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 60 Exploring New Horizons in Chemical Sciences-2019

PP- 54 A Convenient and “Greener” Synthesis of Polyhydroquinoline Derivatives Sanjay S. Kotalwar,a Amol D. Kale,b Ram B Kohire,b Vasant B. Jagrut *b

aDept. of Chemistry, Lal Bahadur Shastri. Sr. College, Partur -431501 (MS) India * bDept. of Chemistry, Swami Vivekanand Senior College, Mantha-431504 (MS) India

*Corresponding Author:[email protected]

Abstract: The most used organic solvents for organic transformation are hydrocarbons, ethers and alcohols; they have a detrimental impact on the health and environment, therefore the choice of the solvent play crucial role in a chemical reaction. The search for a better reaction system for the organic transformation in term of mild reaction conditions, economic viability, selectivity and environmental concerns continues to attract the interest of synthetic organic chemists. In this context, more attention is found to be directed on use of nonvolatile organic solvents as an alternative like PEGs, water and ionic liquids. However all these are having own limitations. Keeping in view here, we have developed efficient, safer and greener synthetic route for polyhydroquinoline derivatives using P-TSA as catalyst in cosolvent (glycerol-water mixture) as greener reaction medium. The mild reaction conditions, non- toxic and biodegradable reaction medium manufactured from renewable sources, use of inexpensive and non-hazardous catalyst are unique features of this method.

O O R OEt O O 2 CHO NH4OAc P-TSA,10mol% O O O R 4 glycerol-water N 1 H 5 3 PP-55 Synthesis of 4, 5-Diarylidene-1, 2, 3, 4, 5, 6, 7, 8-octahydro-9-arylacridine Using Cellulose sulfuric acid Catalyst: Green Approach

1 2 3 1 Rupali L. Magar , Prashant B. Thorat , Bhagvan R. Patil and Rajendra P. Pawar * 1Deogiri College, Aurangabad- 431005, MS, India. 2Smt. C. H. M. College, Ulhasnagar, Thane, 421003 MS India. 3Sharda Mahavidyalaya, Parbhani- 431401, MS, India.

*Corresponding Author: [email protected] Abstract: Method describes an efficient synthesis of cycloalkenopyridine derivatives using aromatic aldehyde, cyclic ketone and ammonium acetate in presence of heterogeneous catalyst cellulose sulfuric acid under solvent free conditions. The catalyst was able to catalyze reaction for various aromatic aldehydes to provide excellent yields for products. The present protocol gives several advantages such as green reaction conditions, easy work-up, easy separation of catalyst and reusability of catalyst. O Ph

CSA 3 Ph O + 2 + NH4OAc Solvent, N Temperature 1a 2 3 Ph 4a Ph

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 61 Exploring New Horizons in Chemical Sciences-2019

PP-56

Efficient Synthesis Of 2, 4, 5 -Triaryl imidazole: An Anti-inflammatory

Arshia Parveen, Shaikh Kabeer Ahmed, R.P.Pawar

Department of Chemistry, B. Raghunath College, Parbhani-431401(MS) Department of Chemistry, Sir Sayyed College, Aurangabad. Department of Chemistry, Devgiri College, Aurangabad.

*Corresponding Author: [email protected], [email protected]

Abstract: An efficient and rapid one-pot synthesis of 2, 4, 5-triaryl imidazole is carried out at 75oC using aromatic aldehyde, benzil or benzoin in the presence of catalytic amount of ceric ammonium nitrate. Excellent yield in short reaction time is characterized by simple work up procedure and efficient recovery. Key words: ceric ammonium nitrate CAN, 2, 4, 5-triaryl imidazole, aromatic aldehyde, benzil, benzoin,

CHO H O O N R` or CAN,NH4OAc o N 0 OH CH3CN, 75 C R' 2 3a-3o 1a 1b PP- 57

A New Approach To The Synthesis Of 4-Thiazolidinone Using Silica gel as Catalyst and to study their Anti-Microbial activities

R. M. More, S. P. Dalvi, S. B. Junne* Organic synthesis laboratory, PG Department of Chemistry, Yeshwant Mahavidyalaya Nanded *Corresponding author:[email protected]

Abstract: Interesting scaffold 2,3-disubstituted 4-Thiazolidinone has been synthesized by three component reaction between substituted 1,3-disubstitued pyrazole- 4-carbaldehyde, Heterocyclic Amines and Thiogycolic acid using Silica gel as a catalyst the reaction is monitored on TLC plate, these synthesized compounds conformed on the basis of spectral analysis such as IR, NMR and Mass spectroscopy. These newly synthesized compounds show good to moderate microbial activities as compared with standard drug. Keywords: 4-Thiazolidinone, 1,3-disubstitued pyrazole- 4-carbaldehyde, Thiogycolic acid.

R2 R O R H 3 R2 N O OH N HS N N N + R N NH+ Silica Gel 3 2 N O S THF, rt 4 hr

R1 R

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 62 Exploring New Horizons in Chemical Sciences-2019

PP- 58 An efficient synthesis of 2-arylbenzothiazoles: A natural approach Uddhav N. Chaudhar1 and Kabeer A. Shaikh2*

1Department of Chemistry, Kalikadevi Art’s, Science & Commerce College, Shirur (Ka.) Dist. Beed-413 249 [M.S.]-India. 2P. G. Department of Chemistry, Sir Sayyed College of Art’s, Commerce & Science, Aurangabad-431 001 [M.S.]-India

*Corresponding Author: [email protected]

Abstract: An efficient, simple and green protocol has been developed for the synthesis of 2-arylbenzothiazole via condensation of 2-aminothiophenol with various types of aromatic aldehydes using tamarind juice as a natural catalyst. The key advantages of this method are mild reaction conditions, inexpensive catalyst, short period of time and high to excellent yield.

Keywords: 2-arylbenzothiazole, Aromatic aldehydes, Tamarind juice, 2-Aminothiophenol

CHO

NH2 N R Tamarind Juice + R.T, 30-40 min. S SH R 3a-l 1 2

. PP- 59 Synthesis, characterization, antibacterial and antifungal studies of binuclear metal complexes of Cu(II) Ni(II) and Co(II)Via Inter –complex Reaction 1 2 Dr. Mahananda A. Raut , Dr. Archana A. Kachare Department of Chemistry, Prathisthan mahaviadhylaya Paithan .Dist Aurangabed (M.S.) India

*Corresponding Author: [email protected]

ABSTRACT: Binuclear Schiff base complexes of Cu(II),Ni(II) and Co (II) were prepared by inter-complex reaction between the corresponding metal complexes of 3-ethoxy Salicyaldehyde and 2-amino 3-hydroxy pyridine. The complexes were characterized by elemental analysis and estimation of metals. Thermal behavior of the complexes was studied by TG-DTA analysis. Structures of the complexes were elucidated by spectroscopic methods like, infrared spectroscopy, UV-visible spectroscopy, mass spectrometry and 1HNMR spectroscopy. The powder X-ray diffraction study suggested crystalline nature of the complexes with tetragonal geometry. Magnetic moments and electronic spectra reveal tetrahedral structure of the complexes. Antibacterial activity of complexes were studied against Gram- positive bacteria, Staphylococcus aureus, Bacillus subtilis and Gram-negative bacteria, Salmonella typhi, Escherishia coli by agar cup method. Their antifungal activity was also tested against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergillus flavus by poison plate method using potato dextrose agar medium at one percent concentration. All complexes show considerable antimicrobial activity.

Keywords: Schiff base, inter-complex reaction, binuclear complex, biological activity

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 63 Exploring New Horizons in Chemical Sciences-2019

PP- 60

Synthesis, Characterization and Antimicrobial Study of Some Cu (II), Ni (II), Co (II) and Zn (II) Schiff Base Metal Complexes Dinkar P. Kotwal1, S. R. Bhusare2 and N. W. Choudhari3 1,3Department of Chemistry, Dnyanopasak Shikshan Mandal’s Arts, Commerce and Science College, Jintur-431 509, MS, India 2Department of Chemistry, Dnyanopasak College, Parbhani-431401, MS, India

*Corresponding Author: [email protected]

Abstract: Schiff base ligand 2-Hydroxy-4,5-diiodo-benzylidene-4-hydroxy-aniline and its complexes with Cu (II), Ni (II), Co (II) and Zn (II) were prepared and characterized by analytical, spectroscopic (IR, UV-Vis) techniques, electrical conductivity, thermal study and magnetic measurements. The results indicate that the ligand coordinate through azomithine nitrogen and oxygen of enolic group. The complexes were further screened for antimicrobial activity.

Keywords: Schiff base, metal complexes, microbial study.

PP- 61

Identification of Novel Degradation Impurities in Solifenacin Succinate and Development of Rapid Stability-Indicating RP-HPLC Method Rajiv A. Jadhav1,2 Sanjay A. Jadhav2, Shashikant B. Landge2, Navanath C. Niphade2 , Prabhakar R. Pawar2 and Saroj R. Bembalkar2 1Wockhardt Research centre, Wockhardt Ltd, D-4, MIDC Chikalthana MIDC, Aurangabad, 431006; 2 Department of Chemistry, Deogiri College, Aurangabad, 431005, India.

*Corresponding author: [email protected]

Abstract: A simple, inexpensive, rapid and novel stability indicating reversed phase liquid chromatographic method employing a Zorbax-CN column has been developed and validated for the determination of both assay and related substances of solifenacin succinate in drug substance and drug product . During the forced degradation at acid, base, oxidative, photolytic and thermal stressed conditions, the degradation results were only observed in the acid and base stress condition. The novel degradation impurities have been identified by LC-MS and characterized by MS, 1H NMR and FT-IR spectroscopy. Good separations were achieved by a gradient elution of phosphate buffer (pH 3.5) and solvents mixture (acetonitrile, methanol and water), at a flow rate of 1.0 mL min−1. The detection was at 220 nm. The developed RP-LC method was validated in agreement with ICH requirements. The force degradation studies prove the stability indicating power of the method and therefore, the validated method useful for the routine analysis of solifenacin succinate as bulk drug and in respective dosage forms. The presented method could be applied for assay and related substances determination of solifenacin succinate in pharmaceutical laboratories and industries.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 64 Exploring New Horizons in Chemical Sciences-2019

PP- 62 A one pot three component approach for the synthesis of Spirooxindole derivatives using Copper nanoparticles grafted on carbon microsphere as heterogeneous catalyst.

N. S. Kaminwara, S. B. Patwaria, Pravin Kendrekarb, Samson Masheleb, and R. P. Pawarc* aDepartment of Chemistry, L.B.S. College, Dharmabad. bDepartment of Health Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa. cDepartment of Chemistry, Deogiri College, Aurangabad.

*Corresponding author:[email protected] Abstract: The metal organic framework of Copper nanoparticles grafted on carbon microsphere is employed for an efficient one pot three component synthesis of spirooxoindole derivatives involving isatin, malononitrile and enolisable C-H acids such as 3-methyl 1-phenyl 2-pyrazolin 5-one, 4-hydroxy 6- methyl 2-pyrone and 1-methyl 4-hydroxy quinoline 2-one. The cheap starting material, easy separation, high catalytic efficiency and reusability of the catalyst for several times without loss of its efficiency, good yield of products and simple workup are promising features of the reaction under 1:1 aqueous alcoholic media. O

O O O NH2 R Cu-NP/C NC CN R CN O + + 1:1 Ethanol, reflux O N O N H H 1 a-f 2 3 a-d CH 4 a-l 3 CH3 OH OH

O 3a = N 3b = 3c= O N 3d = Cl N O H3C O O CH3

PP- 63 Nanoceria as an efficient and green catalyst for the chemoselective N-tert- butyloxycarbonylation of amines under the solvent-free conditions Ajit P Ingalea R H Taleb and Sandeep V Shindec

aDepartment of Chemistry, Dada Patil College, Karjat, Ahmednagar. bSchool of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded. cDepartment of Chemistry, Pratibha Niketan College, Nanded. *Corresponding author: [email protected] Abstract: A simple, efficient and green protocol has been developed for chemoselective N-Boc protection of amines by using nano cerium oxide catalyst under the solvent-free conditions at room temperature. The varieties of functionalized aliphatic, aromatic as well as heteroaromatic amines were protected by using developed protocol. Aliphatic as well as aromatic diamines were converted to exclusively mono-Boc protected derivatives without formation of ureas or bis-N-Boc derivatives. The rapid reaction rate, mild conditions, functional group tolerance, excellent yield, solvent-free reaction, easy recovery and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 65 Exploring New Horizons in Chemical Sciences-2019

PP- 64 Design, Synthesis and Antimicrobial Activity of someTriazine Chalcones Ravindra S. Shinde *1, Satish A. Dake2, Rajendra P. Pawar2 1Research Center in Chemistry, Dayanand Science College, Latur-413512, MS, India 2Department of Chemistry, Deogiri College, Aurangabad-431 005, MS, India

*Corresponding Author: [email protected].

Abstract: The triazine chalcones have been synthesized by the Claisen-Schmidt condensation usingtriazine ketone andsubstituted benzaldehyde in methanol.The obtained compounds were confirmed by spectral data (IR,1H NMR and Mass spectroscopy). All the synthesized derivatives (3a-l) were biological screened for their anti-bacterial and antifungal activities. The synthesized compounds are found antibacterial against human pathogenic microorganisms. All compounds are found potential anti-fungal against Candida albicans MTCC 227, Candida glabrata NCIM 3236, Candida tropicalis NCIM 3110, and Aspergillusniger NCIM 545 fungi were used for study.

O N O

N N O CHO O NH N H Methanol N N R + R NaOH N O 1 2 3a-l O PP-65

Synthesis, Molecular Docking and Antimicrobial Activity of 3,5-diaryl-4,5- dihydro-N-phenyl pyrazolines: Structure-Activity and Relationship Ravi R. Vidulea,b, G. B. Rahatikarb , Mohammad A. Baseerb*.

aDepartment of Chemistry, Shri Sant Gadge Maharaj Mahavidylaya Loha, Nanded-431608, India aDepartment of Chemistry, Yeshwant Mahavidyalaya, Nanded- 431603, India

*Corresponding Author:[email protected] Abstract: Pyrazolines are the well known nitrogen containing heterocyclic compounds, the substituted pyrazolines derivatives in which the substitutions like halogens, electron donating, electron withdrawing groups were occupying the prime position because of their miscellaneous biological applications. A novel series of 3,5-diaryl-4,5-dihydro-N-phenyl pyrazolines (2a-d) from 3,5-substituted-2- hydroxyacetophenones (1a-d) derivatives and phenyl hydrazine were refluxed in ethanol in an acidic medium. The synthesized derivatives were characterized by FT-IR, 1H NMR, 13C NMR, LCMS and elemental analysis. The molecular docking study of the synthesized derivatives performed. All these synthesized derivatives screened for antibacterial and antifungal. OH O R1 OH R1 NH2-NH-Ph R3

R3 EtOH/ A. A. R2 N N R2 Ph (1a-d) (2a-d)

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 66 Exploring New Horizons in Chemical Sciences-2019

PP- 66

HEPES Buffer mediated synthesis of 3, 4-dihydro-3, 3-dimethyl-9- phenylacridin-1-ones under reflux temperature

Suchita S. Gadekara, Suryakant B. Sapkalb, Balaji R. Madjea* aDepartment of Chemistry Vasantrao Naik College, Aurangabad-431003, India. bDepartment of Chemistry, Jawaharlal Nehru Engineering College, Aurangabad-431 004, India.

Corresponding author: [email protected] Abstract: One pot three component synthesis of 3,4-dihydro-3,3-dimethyl-9-phenylacridin-1(2H,9H,10H)-one derivatives has been described by the cyclocondensation of aromatic aldehydes, aromatic amines and dimedone in the presence of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) in ethanol on magnetic stirrer at reflux condition. Besides buffering agent, HEPES as an organocatalyst has been used for the first time in multicomponent organic transformation and succeeded along with various merits of green chemistry practices. Reaction is mechanized by zwitterionic interactions between organocatalyst and reactants to form targeted molecules.

Keywords: HEPES Buffer, phenylacridin-1-ones, reflux temperature, Organocatalyst

PP- 67 A novel Schiff base of 3-formyl-6-methylchromone and 3-aminoquinoline and its Cu (II) and Co (II) complexes: Synthesis, Characterization and Antimicrobial screening studies Sushil K. Ghumbre1,*, Sachin S. Sagar1, Atul S. Renge2, Bhimrao C. Khade3

1Department of Chemistry, I.C.S. College of Art’s, Commerce and Science, Khed-415 709, India 2Department of Chemistry, Konkan Gyanpeet Karjat College of A.S.C., Karjat, India 3Department of Chemistry, Dnyanopasak College of Art’s, Commerce and Science, Parbhani-431 401, India

*Corresponding author:[email protected]

Abstract: A novel Schiff base 6-methyl-3-((quinolin-3-ylimno) methyl)-4H-chromen-4-one obtained by the condensation of 3-formyl-6-methylchromone and 3-aminoquinoline and synthesis of its Cu (II) and Co (II) complexes. Schiff base and its complexes have been characterized by analytical data, elemental analysis, molar conductance, magnetic moment and thermogravimetric analysis. The structural elucidation of prepared compounds carried out by UV-Visible, infrared 1HNMR spectroscopic techniques. The elemental analysis revealed metal to ligand stoichiometry was 1:2. Spectroscopic studies and magnetic moment data interpret octahedral geometry of the complexes. The measured low molar conductance values in DMF indicate that complexes are non-electrolyte. The synthesized compounds were evaluated by in vitro antimicrobial analysis and results were compared with standard tetracycline. Schiff base and its metal complexes shown remarkable antibacterial and antifungal activity.

Keywords: Schiff base, Antimicrobial activity, 3-Aminoquinoline, 3-Formyl-6-methylchromone.

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PP-68

Study of some new corrosion inhibitor of mild steel in HCl and H2SO4 acid

Bhagat S. M.

Department of Chemistry I.C.S. College of Art’s, Comm. and Science, Khed. Dist.-Ratnagiri-415709

*Corresponding Author:[email protected]

Abstract: Corrosion is electrochemical process, due to this process corrosion takes place. Corrosion is challenge in industrial field as well as construction field. It directly affect on economy of these field i.e. economical loss is there. The aim of this research is that to minimize the corrosion or nullify by using some new inhibitor to control the corrosion. In this work mild steel is used which is available in local market. 0.1 M solution of hydrochloric acid and sulfuric acid are used as corrosive media and some d- block metal ion chelates are used as corrosion Inhibitor. Weight loss method is used to analyze the result. Results show the d-block metal ion chelates acts as corrosion Inhibitor.

Keywords: Corrosion, Inhibitor, Mild steel, Hydrochloric acid, Sulfuric acid.

PP-69

Development and evaluation of green synthesized silver nanoparticle gel of Aegle Marmelos leaves extract for skin diseases

Shweta Saboo Government College of Pharmacy, Aurangabad.

*Corresponding author: [email protected]

Abstract: The present study was carried out to prepare and characterize silver nanopartilce gel of methanolic extract of leaves of A.Marmelos. For the study A.Marmelos leaves were collected from local area of Bhagyanagar area Dist.Aurangabad and authenticated by botany department of Dr. Babasaheb Ambedkar Marathwada University, Aurangabad. Macroscopic features and physicochemical parameters of leaves were determined by standard methods. Leaves were extracted firstly with pet ether to remove fatty material and then with methanol by Soxhlet extraction assembly to extract water soluble phytoconstituents. Then methanolic extract was evaluated qualitatively by using various chemical tests and quantitatively by using standard methods. Positive results were given by chemical tests for alkaloid, carbohydrate, protein, steroid, flavanoids, tannins, fixed oil, phenolic compounds. Quantitative estimation carried out for flavonoids and tannins. AgNP's were successfully synthesized by using extract of A. Marmelos and evaluated for their antibacterial activity. Plant extract of A.Marmelos served as a green source for reducing silver nitrate to AgNP's. AgNP's gel (0.5 % w/w) when compared with marketed 0.2% w/w silver nitrate gel showed moderate zone of inhibition against pathogenic bacteria like S.Aureus and C.Albicans responsible for skin diseases. Compared to extract, Silver Nanoparticles Gel is more effective. Besides that Silver Nanoparticle Gel exhibited cytotoxic activity against melanoma cell lines in vitro.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 68 Exploring New Horizons in Chemical Sciences-2019

PP- 70 Acoustic and Thermodynamic Properties of Binary Liquid Mixtures Using DMSO at Different Temperatures S. R. Dandwate1*, S. B. Deshmukh2 1 Research Student, Department of Engineering Science, SRES, Sanjivani College of Engineering, Kopargaon, 423 603, (Maharashtra), India 2Department of Physics, JES College Jalna, 431203, (Maharashtra), India *Corresponding author: [email protected] Abstract: Using fundamental parameters ultrasonic velocity, density and viscosity; different acoustic and thermodynamic properties have been studied over wide range of concentrations at different temperatures from 295.15 K to 315.15 K for binary liquid mixtures of DMSO andbutanol. Isentropic compressibility, acoustic impedance, molar volume, intermolecular free length, available volume and their excess values have been calculated. Redlich-Kister polynomial equation has been used to correlate deviation in viscosity, excess isentropic compressibility and excess molar volume. Insights of non-ideal behavior of liquid mixture and intermolecular interactions have been discussed by correlating the experimental data using Jouyban-Acree model.

Keywords: Acoustic, thermodynamic, binary, Jouyban-Acree model, Redlich-Kister polynomial equation

PP- 71 Kinetic and Isotherm models for the Adsorption of Acid Red 1 from aqueous solution by Parthenium hysterophorus L. A. M. Zinea, S. N. Thoreb, R. P. Pawarb, S. D. Pardeshic, N.M. Ligdec, J. P. Sonarc aDepartment of Chemistry, Majalgaon Arts, Science and Commerce College, Majalgaon, Dist. Beed- 431131, Maharashtra, India. bDepartment of Chemistry, Vinayakrao Patil Mahavidyalaya, Vaijapur, Aurangabad-423701, Maharashtra, India cDepartment of Chemistry, Deogiri College, Station Road, Aurangabad- 431 005, Maharashtra, India. *Corresponding Author: [email protected] Abstract: The adsorption behavior of Acid red 1 onto Parthenium hysterophorusL from aqueous solution was investigated. Adsorption kinetics, equilibrium, and thermodynamics were investigated as a function of initial concentration and temperature. Three kinetic models – the pseudo first-order, second order and Elovich were used to investigate the adsorption mechanism. Evaluation of kinetic models showed that the pseudo first order kinetic model was found to correlate the experimental data. The adsorption data were modeled by using Langmuir, Freundlich and Temkin adsorption isotherms. The data were well represented by Langmuir isotherm equation and the calculated thermodynamic parameters indicated a spontaneous and exothermic nature of the adsorption process.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 69 Exploring New Horizons in Chemical Sciences-2019

PP- 72 Chemoselective thiocyanation of imidazothiazole derivatives through one pot multicomponent protocol Shuddhodan N. Kadam, Ajay N. Ambhore, Rahul D. Kamble,Madhav J. Hebade, Shrikant V. Hese, Milind V. Gaikwad, Priya D. Gavhane, Bhaskar S. Dawane* School of chemical sciences, Swami Ramanand Teerth Marathwada University, Nanded (MS), India 431606. *Corresponding author: [email protected] Abstract: A chemoselective multicomponent protocol for thiocyanation of imidazothiazole derivatives at room temperature is described. Current protocol offers chemoselectivety for electrophilic substitution in imidazothiazoles against nucleophilic substitution. Present protocol provides metal free and efficient access for C-3 thiocyanation of imidazothiazole bearing alcoholic as well asC (sp2)-Hbond functionality.

PP- 73 Synthesis, Characterization and Biological Studies of Transition Metal Complexes of N-4-Disubstituted Thiosemicarbazone

Vrushali. S. Gavhane, Anjali. S. Rajbhoj, Suresh. T. Gaikwad* Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, (M.S) India-431 004

*Corresponding author: [email protected]

Abstract: Complexes of transition metal ions with N-4-disubstituted thiosemicarbazone were synthesized. Salicylidene N-4-substituted thiosemicarbazones were prepared through condensation of salicylaldehyde and N-4-disubstituted thiosemicarbazide. The characterization of newly formed compounds was carried out by 1H-NMR, FTIR spectroscopy, elemental analysis, molar conductance, magnetic measurement. In addition, the structure of the complex has been determined by X-ray diffraction method. IR spectrum of ligand and the metal complexes indicate the existence of bidentate as well as tridentate nature of ligand which undergoes coordination to metal ions with ONS donor atom sets. The ligand and its metal complexes were also tested for biological activities.

Keywords: N-4-Disubstituted thiosemicarbazide, Biological studies.

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PP- 74 One pot synthesis of pyranopyrazole using sodium lactate as a efficient catalyst J. P. Sonar a, G. M. Bhavar a, S. D. Pardeshi a, S. A. Dokhe a, S. U. Tekale c, A. M. Zine b, S. N. Thore c,*

aDepartment of Chemistry, VinayakraoPatil Mahavidyalaya, Vaijapur, Aurangabad-423701, Maharashtra, India bDepartment of Chemistry, Majalgaon Arts, Science and Commerce College, Majalgaon, Dist. Beed- 431131, Maharashtra, India. cDepartment of Chemistry, Deogiri College, Station Road, Aurangabad- 431 005, Maharashtra, India.

*Corresponding Author:[email protected]

Abstract: One pot synthesis of pyranopyrazole has been achieved from hydrazine hydrate, methyl acetoacetate, aromatic aldehydes and malononitrile efficiently. We are reporting sodium lactate as catalyst in aqueous media at 80oC temperature. This method is highly efficient to give pyrano pyrazole in short time.

Keywords: Sodium lactate, one pot multicomonent CHO

R R NH2 N NH 2 Sodium Lactate CN O + aq. Ethanol N N N EtO H O NH2 O

Scheme 1: Sodium lactate catalyzed synthesis of pyranopyrazole

PP- 75 Green Approach for the Synthesis of Biologically Active Heterocyclic Compounds R. E. Khadse Department of Chemistry, Late Pundalikrao Gawali Arts and Science College, Shirpur (Jain) Tal. Malegaon Dist. Washim *Corresponding Author:[email protected] Abstract: Synthesis of N, O and S containing heterocycles has owing to a wide variety of their biological activity. Green chemical one-pot multicomponent condensation reaction is found to be catalyzed by AgO (Silveroxide) using water as a good solvent to give the corresponding Schiff bases in good yields. This method is experimentally simple, clean, high yielding and reduced reaction times. Syntheses of heterocycles under solvent-free, microwave irradiation condition have appeared. The important role of solvent-free condition coupled with microwave activation and their advantages in the synthesis of Substituted 14-aryl-14-14H-dibenzo xanthene, Substituted 3-Styrylchomone and Substituted 5- benzylidine2,4-thiazolidine. This heterocyclic compound shows biological activities, includes anti- bacterial, anti-fungal, anti-diabetic, cardiotonic and anti-convulsant.

Keywords: Solvent Free Synthesis, Solid Support, Microwave Irradiation, Green Synthesis, Bioactive Heterocycles.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 71 Exploring New Horizons in Chemical Sciences-2019

PP- 76 An Overview of Recent Advances in Analytical Instrumentation Shinde Achut Ramrao Department of Chemistry & Analytical Chemistry, SanjeevaneeMahavidyalaya, Chapoli, Tq. Chakur, Dist. Latur. *Corresponding author: [email protected] Abstract: The major revolution in the analytical chemistry was observed in between the year 1920 and 1950. Within these period major changes in the natural science was observed due to the advancement in the analytical instrument. Prior 1920 analytical chemist determine chemical composition of unknown substance by performing series of chemical test with known compound and observing the kind of reaction they underwent.After 1950 different varieties of analytical instruments advised and were used by the chemical analyst for the determination of chemical constitution of unknown compounds. Analytical instruments determine chemical constitution by the decrementing physical properties of the constituent. Analytical instrumentation is the back bone of the scientific research and over all development of scientific research in many developing countries. Since from last many decade there is tremendous advancement in the analytical instruments were done with the help of science and technology. Many problems related analysis and identification is solved with the help of advanced analytical instruments such as spectrophotometers, flame photometers, turbidometers, colorimeter, mass spectrometer, NMR instrument, conductometer, potentiometer, polarography, atomic force microscope, X-ray, electron microscopy. Chromatography and distillation is widely used separation techniques in the various branches of the science. In the present study an over view of some widely used instruments and their application in the various branches of science were mentioned.

Keywords: Analytical instruments, Spectrophotometers, Flame photometers, Chemical constitution.

PP- 77 Removal of Heavy Metals by Low Cost Material 1 2 3 4 Sayyed Hussain , Momin Kalimoddin , Farooque Ansari , Deepak Kayande

1Post Graduate Department of Chemistry, Sir Sayyed College, Aurangabad 2Rasjashree Shahu College Latur 3RizviCollege, Bandra (W) Mumbai 4 SB College Auranagbad *Corresponding author: [email protected]

Abstract: In the Present work the enicostemmalittoraleare used as adsorbent for removal of heavy metals like Fe(III), Cu(II), Cr(II) from aqueous solution. The adsorption characteristics of all three metals on enicostemmalittorale were evaluated as a function of varying adsorbent dose, tempera ture and time. The percentage removal of Fe(III), Cu(II), Cr(II) bytitanium oxide enicostemmalittorale carried under different conditions, during this findings was significant. The order of adsorption ontitanium oxide enicostemmalittorale of metals ions were Cu >Fe>Cr during the findings. The adsorption data fitted well into Freundlich and Langmuir adsorption models. The results show that titanium oxide enicostemmalittorale hold a great potential in removal of metal ions from aqueous solution. The Thermodynamic study has showed that the Fe(III), Cu(II), Cr(II) ions adsorption on the surface of titanium oxide enicostemmalittorale was physical adsorption and the process was spontaneous and exothermic.

Keywords: Enicostemmalittorale, Heavy metal ions, Freundlich isotherm, Langmuir isotherm, Low cost material

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PP- 78

Synthesis and application of acetic anhydride as organic reagent by novel methods V. M. Kamble*, Megha Shankar Gharge

Department of Chemistry, the Institute of Science-15, Madam Cama Road, Mumbai-32

*Corresponding author: [email protected]

Abstract: Simple and improved methods have been found to carry out the preparation of acetic anhydride from acetic acid. This preparation was performed by using calcium chloride. This method should be cheaper, greener and less hazaradous. This preparation method involves following steps refluxing, distillation, and recrystallization and finally acetic anhydride was examined and identified by spectroscopic analysis. The advantage of this method is operational simplicity and avoidance of use of organic solvent and eco-friendly preparation.

Keywords: Glacial acetic acid, Calcium chloride.

PP- 79

Visible-light photocatalytic activity of Cr-doped TiO2 nanoparticles by modified sol-gel method

D. V. Aware Department of Chemistry, Shri Dnyaneshwar Mahavidyalaya, Newasa, MS, India

*Corresponding Author: [email protected] Abstract Chromium doped titaniana nanoparticles have been successfully synthesized by modified sol-gel process. After calcination at 500oC, the resultants Nanomaterials have been characterized by XRD, SEM-EDX and UV–vis absorption spectroscopy. The powder XRD result revealed that decrease in grain size with increase in dopant concentration. The SEM micrographs revealed the spherical-like morphology while EDX confirm presence proper proportion elements in the synthesized Nanomaterials. The absorption edges of TiO2 nanoparticles shift towards longer wavelengths (i.e. red shifted) from 400 nm to about 700 nm with increasing Cr concentration, which greatly enhances TiO2 nano-materials on the absorption of solar spectrum. The small grain size, high crystallinity and decrease in the band gap energy of doped Titania may be responsible for the high photocatalytic activity.

Keywords: Ferrite, Sol-Gel, XRD, SEM; EDX; UV-Vis DRS, dye degradation.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 73 Exploring New Horizons in Chemical Sciences-2019

PP- 80

Effect of Strontium Doping on Properties of CuFe2O4 Synthesized by Modified sol-gel Method R.Y. Darkunde and C. S. Patil* Department of Chemistry, Shri Dnyaneshwar Mahavidyalaya, Newasa, MS, India *Department of Chemistry, Deogiri College, Aurangabad, MS, India

*Corresponding author: [email protected] Abstract: Series of Sr- doped copper tartarate precursors were synthesized by modified sol-gel method and were calcined at 700 0C. The resultant ferrite material was characterized by sophisticated analytical techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX). Powder XRD pattern results the formation of nano crystalline single phase spinel structure with average grain size in the range 12 to 27 nm in all the ferrite composites. The XRD pattern confirms the decrease in grain size with dopant concentration. The SEM images revealed the clustered nano particles with irregular morphology. The presence of proper proportion of elements in the nano-composites was confirmed by EDS study. The effect of strontium doping on the structural and electrical properties of copper ferrites calcined at high temperature have been examined.

Keywords: Ferrite, Sol-Gel, XRD, Spinel Structure; SEM; EDX; Electrical Properties.

PP- 81

Preliminary Phytochemical Screening of Selected Medicinal Plants in Saptashrungi Ghad of Nashik District (M.S) India

M. R. Bacchav Department of Chemistry, Karm. Ramraoji Aher Arts, Science & Commerce College

*Corresponding Author:[email protected]

Abstract: A survey was carried on Saptashrungi gad and the surrounding area of Dhodalmal ghad, etc. for the study purpose. The aim of present study is to test the presence of various Phytochemical in selected medicinal plants from Saptashrungi Ghad used in treatment of different types of diseases. An interview was taken of the local tribal people who are using medicinal plants for the treatment of various types of diseases around the selected area from last many decades. For this study four medicinal plants such as Centalla Asiatica, Vitex negundo, Tylophora indica, Eostar igeneiy (Insulin) were selected and found to be useful in the treatment of various diseases such as asthma, cough, yellow fever, malaria, ringworm, boil, eczema, typhoid and diabetes.

Keywords: Medicinal plants, Ghad, Fever, Diseases

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 74 Exploring New Horizons in Chemical Sciences-2019

PP- 82

Synthesis of Benzimidazole Derivatives using Recyclable Ionic Liquid at Room Temperatutre.

Dr. Sangita Sanjay Makone* and Naushaba Tazeen School of Chemical Sciences, S. R. T. M. University, Nanded-431606, Maharashtra.India. *Corresponding Author: [email protected] Abstract: The new method of synthesis of benzimidazole derivatives by a mixture of o- phynylenediamine with substituted aldehydes was stirred at room temperature in the solution of ethanol, catalysed by ionic liquid. The structure of the novel benzimidazole compounds were confirmed by various spectroscopic analyses and further tested for its biological activity. To overcome the drawbacks of chemical method there is growing demand for the development of organic reactions in environment friendly conditions. This method has several advantages such as simple work-up procedure, involving short reaction time, high yields of the product formation, eco-friendly and reusability of catalyst.

Keywords: Ionic liquid, Benzimidazole, o- Pheylenediamine, Ethanol O

NH2 N R H IL EtOH NH RT R 2 N

PP- 83

Novel oxadiazole incorporated quinoline derivatives induced G2/M arrest and apoptosis in human breast cancer MCF-7 cell line Dr. Vidya S. Dofe Deparment of Chemistry, Shiv Chhatrapati College Aurangabad, Maharashtra India.

*Corresponding author: [email protected]

Abstract: In search of novel anticancer agents, we designed and synthesized a series of quinoline-based oxadiazole derivatives and assayed in vitro cytotoxic efficacy against human breast cancer MCF-7 cell line. The most promising compounds in the present series (Q8, S3, S6) showed excellent activity and inhibited growth of breast cancer cell MCF-7 with 50% inhibitory concentration (IC50) of 8.31 µM, 9.81 µM, and 9.96 µM, respectively. The results of the present study reveal reduced IC50 values in dose- dependent mode with high specificity for MCF-7 (IC50 of 10 µM at 24h) versus normal breast cells. Apoptosis assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) also suggested that this compound induced cell death by apoptosis.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 75 Exploring New Horizons in Chemical Sciences-2019

PP- 84 Synthesis of N-2-(4-Substituted benzylideneamino)ethyl)morpholine-4- carboxamide as potent Pharmacologically Biologically Important Scaffolds.

Archana A. Sawale* & Rajlakshmi A. Sawale**

*Late P.R.Patil Utkarsha Jr. College, Virar West-401303. **Indian Institute of Science Education and Research, Pashan, Pune-411008.

*Corresponding Author: [email protected]

Abstract: N-(2-aminoethyl)morpholine-4-carboxamide (I) when treated with aryl/heteryl aldehyde(s)(II) gives N- 2-(4-Substituted benzylideneamino)ethyl)morpholine-4-carboxamide(s)(III). Compound (III) is screened for anti bacterial, anti fungal and anti cancer activities.

Keywords: morpholine-4-carboxamide, benzylideneamino, anti cancer, antifungal and antibacterial.

PP- 85 Complex Equilibrium studies of Sitagliptin drug with Different Metal ions G. B. Akata and B. K. Magareb aDepartment of Chemistry, Kohinoor College Khultabad Dist.Aurangabad (MS) India. bDepartment of Chemistry, Shivaji College Kannad Dist.Aurangabad (MS) India.

*Corresponding author: [email protected]

Abstract: In this present work we investigate the stability constant of Sitagliptin drug with transition metal ions such as Fe(III),Co(II),Ni(II),Cu(II),Zn(II) & Cd(II) using PH metric technique in 20%(v/v) water- ethanol mixture at different temperature conditions and at an ionic strength of specific 0.1M Sodium percholrate. The pH metry is a very useful and successful system utilized for metal complex estimations. The Calvin and Bjerrum method, as modified by Irving and Rossotti, was used to determine the metal- line stability constant values (logK). It is observed that a transition metal ion forms 1:1 and 1:2 complexes. The thermodynamic parameter Free energy (G), Enthalpy (H) and Entropy (S) were calculated from values of stability constant at various temperatures. The synthetic methodology of metal complexes was found to be spontaneous in nature. Sitagliptin is a drug used to treat diabetes mellitus type 2, and it belongs to a new therapeutic class called dipeptidyl peptidase IV inhibitors. This hypoglycemic drug is commercially available in coated tablets containing 25, 50, and 100 mg of sitagliptin base. The purpose of this study was to develop and validate the conditions for the dissolution test by investigating a possible in vivo-in vitro correlation. The sink condition and specificity were determined in all media tested during method development. The parameters evaluated to validate the method were specificity, linearity, precision, and accuracy.

Keywords: Stability Constant, Transition metal, PH metry, Sitagliptin drug, Thermodynamically.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 76 Exploring New Horizons in Chemical Sciences-2019

PP-86 Green Chemistry Approach for the Synthesis of Novel Tetrazole Derivatives and Evaluation of Antifungal Activity *N. D. Bhoge1, B. K. Magare2, P. B. Mohite3, M. S. Jangale4 1*Shri Dnyaneshwar Mahavidyalaya, Newasa, Tal- Newasa, Dist-Ahmednagar, Maharashtra-414105 2Shivaji Arts, Commerce and SciencecollegeKannad, Dist-Aurangabad, Maharashtra-431103. 3MES’s College of Pharmacy, Sonai, Tal- Newasa, Dist-Ahmednagar, Maharashtra-414105. 4Arts, Commerce and Science College Sonai, Tal- Newasa, Dist-Ahmednagar, Maharashtra-414105

*Corresponding author: [email protected] Abstract: In this context new 2-Substituted-4-(5-phenyl-1H-tetrazol-1-yl)-2,3,5a,9a-tetrahydro-1H-1,5- benzodiazepine derivatives were synthesized by conventional as well as microwave method. Benzonitrile and sodium azide in presence of ammonium chloride and DMF produces 5- phenyltetrazole; this on reaction with acetic anhydride forms 5-phenyl 1-acetyl tetrazole which reacted with different aromatic aldehydes in presence of alkaline medium, to yield corresponding chalcones. Chalcones on further reaction with O-phenyldiamine yielded 2-Substituted-4-(5-phenyl-1H-tetrazol-1- yl)-2, 3, 5a, 9a-tetrahydro-1H-1,5-benzodiazepine (4a-4j). The structures of newly synthesized compounds were characterized by physical and spectral characteristics by FT-IR and 1H NMR spectroscopy. All synthesized compound were evaluated for their anti-Fungal activity by MIC (Broth dilution Method) against A.niger and C.Albicans. All synthesized compounds shows moderate to good antifungal activity in which compound (4g) shows more MIC at 120 µg/ml.

Keywords: Chalcones; Tetrazole; Anti-Fungal activity, MIC.

PP- 87

A Review on Green Approaches for Synthesis of Quinoxaline and its Derivatives

Ghorpade P. K.1*, Dr. Mrs. Patil C. S.2, Dr. Pawar R.P.3

1*Shri Dnyaneshwar Mahavidyalaya, Newasa, Dist- Ahmednagar, Maharashtra 414603 2,3Deogiri College, Aurangabad, Maharashtra- 431005.

*Corresponding author: [email protected], [email protected]

Abstract: Quinoxaline and its derivatives are important N-containing heterocyclic compounds. Substituted quinoxalines constitute the bulding blocks of wide range of compounds having antibacterial, antifungal, antitubular antidepressant, antitumor and antituberculer activities. It attracts the researchers to find out more its biological activity.But its traditional synthesis suffers from disadvantages such as pollution, high cost, low yield, tedious work up and long reaction time. Recently different methods have been developed for synthesis of quinoxaline derivatives (Green routes). In present study we provide a concise review on history, chemistry, different methods of Quinoxaline synthesis & biological activity.

Keywords: Quinoxaline, Green route

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 77 Exploring New Horizons in Chemical Sciences-2019

PP-88 Cuprous Bromide Catalysed Oxidative Coupling of Terminal Alkynes with activated SP3-C of Diethyl sulphate

Tukaram S. Choudhare, Vijay T. Kadam, Ajit A. Kharpe and Prashant D. Netankar*

*Maulana Azad Arts Science and Commerce College, Aurangabad-431005

*Corresponding author: [email protected]

Abstract: Alkynes and its derivatives areimportant structural motifs found in a wide range of active pharmaceutical agents and natural product.The inherent characteristics make them useful building blocks in organic syntheses. Transition-metal-catalysed alkylation of terminal alkynes has recently emerged as a powerful synthetic strategy to obtained valuable molecules via the formation of new of C(sp)−C(sp3)bonds. The reported methods commonly use terminal alkynes, haloalkynes, alkynyl carboxylic acids, and other alkynyl analogues or precursors as the substrates. However, the reaction conditions often have some limitations; for instance, bimetal catalytic systems or other activators were required to realize alkynylation by a transmetallization reaction, harsh reaction condition, low yieldand an inert atmosphere was usually necessary to avoid side reactions. Therefore, mild and efficient methods for the formation of C(sp)−C(sp3)bonds developed by using diethyl sulphate in the presence of cuprous oxide as catalyst.

Keywords:, C(sp)-C(sp3) bonds, diethyl sulphate, cuprous oxide.

O CuBr, NaHCO O S O 3 O THF, RT R R

PP- 89

New Synthetic Route for the Synthesis of Naphthoxazoles and its Antifungal Study S. R. Patil*1, J. P. Sonawane2 1PG & Research Department of Chemistry, MGSM A.C.S. College, Chopda, Dist.-Jalgaon 2Department of Chemistry, R. C. Patel A. S. C. College, Shirpur, Dist.-Dhule

*Corresponding author:[email protected], [email protected] Abstract: On the basis of biological and structural properties, 1, 4-naphthoquinones are considered privileged structures in medicinal chemistry. This study deals with the synthesis, characterization of structures and the finding of antifungal properties centered on new 1,4-naphthoquinone nucleus having an oxazole moiety, which can be further useful for biological applications. Multistep synthesis starting from 2- hydroxy-1, 4-naphthoquinone undergo selective nitration followed by reduction, yielded key intermediate 2-hydroxy-3-amino-1, 4-naphthoquinone. The reaction of the latter with various substituted aryl carboxylic acids furnished the title compounds. The in vitro antifungal potential of the newly synthesized compounds was evaluated in a panel of fungal strains.

Keywords: Heterocyclic synthesis, 1, 4-Naphthoquinone, Naphthoxazole, Antifungal activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 78 Exploring New Horizons in Chemical Sciences-2019

PP- 90

Synthesis, Characterization and antimicrobial study of novel tri-iodo 1, 3- diketones and its metal complexes

Sandeep N. Sampal, Premkumar B.Thombre, Sonali A. Korde, Sudarshan S. Dipake, Suresh T. Gaikwad*

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004 (MS) India *Corresponding author: [email protected]

Abstract: The two novel 1,3-diketones such as 1-(2-hydroxy phenyl)-3-(2,3,5 triiodo phenyl) propane 1,3-dione (L1), 1-(5-bromo-2-hydroxy phenyl)-3-(2,3,5 triiodo phenyl) propane 1,3-dione (L2) and its metal complexes with transition metals have been synthesized from 2,3,5 Triiodo aromatic benzoic acid and substituted ortho-hydroxy acetophenone by conventional methods. All the metal complexes synthesized by metal nitrate with 1, 3- Dione (L1 & L2) in the ratio 1:2 stiochimetry. The synthesized ligands and its complexes characterized by Elemental analysis, UV-Visible spectroscopy, Infrared spectroscopy, 1H- NMR, 13C-NMR, Magnetic Susceptibility, Molar Conductance, Powder XRD and TGA. All metal complexes have octahedral geometry with monoclinic crystal system. The synthesized 1, 3-diones and their transition metal complexes have been screened for in vitro antimicrobial activity using Resazurin 96 well plate method. This method is simple, sensitive, rapid, and reliable. It achieves more accurate minimum inhibitory concentration (MIC). The transition metal complexes and ligands showed moderate to excellent antimicrobial activity against all tested bacteria and fungi. Better antioxidant activities for ligands and its metal complexes were observed as compared to the standards.

Keywords: 1, 3-Dione, Metal-complexes, Magnetic susceptibility, XRD, TGA, Antimicrobial activity

PP- 91

Synthesis, Characterization and Catalytic Studies of CuFe2O4 Nanoparticles

1*S. D. Tapsale, 2D. V. Mane, 3S. G. Patil, 4K. M. Jadhav 1Department of Chemistry, Modern College, Pune, (M.S.) India 2Department of Chemistry, S.C.S. College, Omerga (M.S.) India 3Maharashtra Udaygiri Mahavidyalay, Udgir, (M.S.) India 4Department of Physics, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, (M.S.) India *Corresponding author: [email protected]

Abstract: In present work, the synthesis and catalytic properties of the copper ferrite nanoparticles have presented. The wet chemical synthesis technique was employed for the synthesis of copper ferrite nanocatalyst. The purity and crystallinity of the CuFe2O4 nanoparticles were checked by the XRD. The lattice constant and crystallite size were evaluated from the XRD data. The magnetic properties of the prepared copper ferrite catalyst were studied by pulse field hysteresis loop tracer technique at room temperature. The catalytic studies on the copper ferrite nano catalyst were carried for the preparation of coupling reactions derivatives using different solvents by a typical procedure.

Keywords: Copper ferrite nanoparticles, X-Ray diffraction, Infrared, Catalytic activity

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 79 Exploring New Horizons in Chemical Sciences-2019

PP- 92

Synthesis of Diketopyrrolopyrrole (DPP) using ionic liquid as a co-solvent

Virbhadra G. Kalalawe 1, Raju P. Kagne 2, Raoji D. Gutte3, Satej S. Dharmapurikar3* Dashrath R. Munde3*

1Department of Chemistry, Yogeshwari Mahavidyalaya, Ambajogai, Maharashtra. 2Department of Chemistry, Wilingdon College, Sangali, Maharashtra. 3*Department of Chemistry, N.E.S.Science College, Nanded.Maharashtra.

*Corresponding author:[email protected]

Abstract: Diketopyrrolopyrrole (DPP) as an important monomer, precursor for many synthesis conjugated polymers and organic pigments. Herein, we modify the synthesis DPP preparation method, using ionic liquid as a co-solvent. In this study, Furan DPP, Thiophene DPP and Pyridine DPP are synthesized at 70 oC with improved yield reported by previous method. The effect of ionic liquid on the yield is monitored by changing the volume of ionic liquid and t-amyl alcohol. These DPPs are characterized by 1H NMR and 13C NMR. The optical properties are recorded and textures of DPP films are also analyzed.

Keyword: Diketopyrrolopyrrole, Ionic liquid, co-solvent and 1-Methylimidazolium hydrogen sulphate PP- 93

Waterborne polyurethane coatings: HPTS based fluorescente and pH stimuli Dr. Rajesh S. Bhosale School of Sciences, Indrashil University, Rajpur, Taluka Kadi, District Mehsana, Gujarat -382740 *Corresponding author: [email protected]

Abstract: A water-soluble pyrene dye HPTS, was employed to develop highly fluorescent waterborne polyurethane (WPU) via physical dispersion in WPU matrix. Negatively charged sulfonate ions present in HPTS moiety facilitate in homogeneous dispersion of HPTS in WPU matrix. The optical characterization of HPTS-WPU emulsion and films were done by UV-Vis and PL spectroscopy. It exhibit high fluorescence emission in emulsion state as well as in solid state even at very low concentration. The fluorescence intensity was found to increase with increasing weight % of the HPTS dye in WPU matrix. Sensing behavior of these films such as pH was also investigated by exposing to tri fluoroacetic acid (TFA) vapor (pka = 0.23) and ammonia (NH3) vapor (pkb = 9.25). Systematic study revealed that HPTS retained not only its highly green fluorescent nature in WPU matrix but also exhibited pH sensing behavior. The overall analysis suggested that HPTS-WPU could be used to develop an environmentally friendly high fluorescent smart coatings and textiles inheriting real-time pH sensing property.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 80 Exploring New Horizons in Chemical Sciences-2019

PP- 94 Hydrometallurgical recovery of ruthenium (III) by 2-dodecylaminopyridine Umrao B. Shep & Balasaheb R. Arbad*

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (M.S.) India, 431 004. *Corresponding author: [email protected]

Abstract: A Newapproach was designed to extract ruthenium (III) from organic acid solutions via solvent extraction method. In this work extraction of ruthenium (III) from synthetic mixtures of precious and base metals using lipophilic amine: 2-dodecylaminopyridine as the extractant was examined. The extraction performanceof ruthenium (III) was investigated as function of numerousparameters: pH and organic acid concentration of aqueous phase, concentration of extractant, A/O phase volume ratio, equilibrium time, diluents and stripping from organic phase. Under the optimal conditions, extraction efficiency of ruthenium (III) was quantitative which indicate that it is an efficient extraction system for recovery of ruthenium.

Keywords: Solvent extraction, ruthenium (III), ion pair complex, stripping, foreign ions.

PP- 95

Synthesis and anti-inflammatory activities of chromeno pyrimidines towards selective COX-2 inhibitors with better gastric profile Santosh S. Undarea, Navnath J. Valekarb, Dattatraya. K. Jamalec, Aniket P. Sarkated, Shankar P. Hangirgekarb and Prashant V. Anbhuleb* a Medicinal Chemistry Research Lab., Department of Chemistry, Balbhim college, Beed-431122., M.S., India. bMedicinal Chemistry Research Lab., Department of Chemistry, Shivaji University, Kolhapur- 416004., M.S., India. c Shri Shivaji Mahavidyalaya, Barshi-413401., M.S., India. dDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431002., M.S, India. Corresponding author: [email protected] Abstract: A series of chromeno pyrimidine derivatives 1-11 were synthesized and evaluated in vivo anti- inflammatory activity using carrageenan-induced rat paw edema assay. It is found that compounds 4 and 11 shown potent activities with edema inhibition percentage of 90.48 % as compared to diclofenac (96.93%). The results of ulcerogenicity revealed that compounds 3, 6 and 7 have remarkable ulcer index (UI= 2.70-2.80) in comparing with diclofenac (UI= 6.56). Compounds 4 and 11 were potent selective inhibitors to COX-2 than COX-1. According to the docking study, there are Pi-Pi stacking interactions between phenyl rings of compounds 2, 5, 7, 11 and the aromatic amino acid residues like Trp355, Trp387 and Tyr385 respectively.

Keywords: Chromeno pyrimidines, Anti-inflammatory, Ulcerogenic study, COX-2 inhibitors, Molecular docking.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 81 Exploring New Horizons in Chemical Sciences-2019

PP-96

Effect of temperature on Ultrasonic Properties of polar with Non polar liquid. A G Patil 1, Aruna P. Maharolkar 2, A. G. Murugkar 3

1 Vivekanand Arts Sardar Dalipsing Commerce and Science College, Aurangabad, (M.S.) -431004, India 2 G. S. Mandal’s Marathwada Institute of Technology, Aurangabad, (M.S.) -431004, India 3 Department of Physics, Dr. B. A. M. University, Aurangabad, (M.S.) -431004, India.

*Corresponding author: [email protected]

Abstract: Density, viscosity and ultrasonic study for the binary mixtures of Acetone and toulene over the entire concentration range were measured at temperatures 303 K, 308 K. The experimental data then used to calculate the compressibility, and acoustic impedance, molecular free length, Inverse relaxation time and Excess Parameters. The values of excess properties further fitted with Redlich–Kister polynomial equation to estimate the binary coefficients. The resulting excess functions were interpreted in terms of the interactions between the molecules in the binary mixtures. Results confirm that strength of bond depends on concentration and temperature.

Keywords: Compressibility, Acoustic Impedance Binary mixtures, Ultrasonic velocity, Excess parameters

PP- 97

Enhanced photocatalytic activity of Activated carbon loaded porous flower like CdS structures synthesized by solvothermal synthesis

K. S. Bhavsar*a, B. M. Sapkala, P. K. Labhanea, G. H Sonawaneb and R. B. Dhakec aPost Graduate Department of Chemistry, MGSM’S A.S.C.College Chopda, Dist:-Jalgaon, (M.S.), India bKisan Arts, Commerce and Science College, Parola, Maharashtra, India c D. D. N. Bhole College, Bhusawal, Maharashtra, India.

*Corresponding author: [email protected]

Abstract: In this study, activated carbon (AC) loaded flower-like Cadmium sulfide nanocomposite was successfully synthesized by solvothermal method using DETA and ethanol (2:1). The morphology of the as-prepared samples was analyzed by scanning electron microscopy (SEM), powder X-ray diffraction (XRD), and UV-vis diffuse reflectance spectra. BET analysis confirms the higher specific surface area of CdS-AC composites than CdS. The FESEM observations displayed CdS samples exhibit flower-like structure, each flower structure is constructed of several assembled nanosheets. The photocatalytic efficiencies were evaluated by degradation of Rhodamine B dye under sunlight. The CdS-AC exhibits superior photocatalytic efficiency towards the photodegradation of Rhodamine B under sunlight radiation due to combined effect; adsorption and photocatalysis.

Keywords: Diethylene triamine (DETA), Cadmium sulfide (CdS)

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 82 Exploring New Horizons in Chemical Sciences-2019

PP-98

Silica supported Co(ClO4)2: Preparation, Characterization & Synthetic applications * Dr. Nagesh Raghunath Sutar* Department of Chemistry, Smt. Chandibai Himathmal Mansukhani College, Ulhasnagar-421003.

*Corresponding author: [email protected]

Abstract: Silica supported Co(ClO4)2 catalyst was successfully prepared following simple method. Its characterization by TGA indicated its thermal stability up to 350oC giving scope to use it at elevated temperature. Its analysis by standard B.E.T. technique proved diffusion of Co(ClO4)2 in silica support forming -Si-O-Co(ClO4) linkages. It was found to be stable to moisture as well in contrast to free Co(ClO4)2.6H2O. Catalytic activity of silica supported cobalt perchlorate was investigated in one-pot synthesis of biologically active heterocyclic organic compounds where in it was found to be an efficient, recyclable catalyst. The synthetic applications have advantages of high yield, mild conditions and simple work-up procedure.

Keywords: Silica supported, Thermal stability, Diffusion, Catalytic activity

PP-99

Adsorption Thermodynamics and Corrosion inhibition behaviour of Expired Glimepiride on Mild Steel in Hydrochloric acid solution.

L. P. Chaudhari1, S. N. Patel2,* 1, 2*PG and Research Department of Chemistry, S. P. D. M. College, Shirpur, Dist. Dhule, Maharashtra, India

*Corresponding author: [email protected] Abstract: Expired Glimepiride (EG) was usedas corrosion inhibitor for mild steel in 2M hydrochloric acid solutionThe corrosion inhibition efficiency of EG on mild steel (MS) have been investigated using Gravimetric measurements, potentiodynamic polarization studies andelectrochemical impedance spectroscopy (EIS). Expired Glimepirideshows good inhibition on mild steel in HCl medium even at low concentrations and the inhibition efficiencies increases with increase in concentration of the inhibitor.The effect of temperature on the corrosion rate of mild steel in the absence and presence of EG was also studied. Adsorption study suggest Langmuir adsorption isotherm. Thermodynamic parameters are calculated which confirms that the adsorption process is spontaneous.

Keywords: Expired Glimepiride, Acid, Corrosion, Adsorption isotherm

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 83 Exploring New Horizons in Chemical Sciences-2019

PP- 100

A novel Schiff base of 3-formyl-6-methylchromone and 3-aminoquinoline and its Cu(II) and Co(II) complexes: Synthesis, Characterization and Antimicrobial screening studies

Sushil K. Ghumbre1*, Sachin S.Sagar2, Atul S. Renge3, Bhimrao C. Khade4

1Department of Chemistry, I.C.S. College of Art’s, Commerce and Science, Khed-415 709, India 2Department of Chemistry, I.C.S. College of Art’s, Commerce and Science, Khed-415 709, India 3Department of Chemistry, Konkan Gyanpeet Karjat College of A.S.C., Karjat, India 4Department of Chemistry, Dnyanopasak College of Art’s, Commerce and Science, Parbhani-431 401, India

*Corresponding author:[email protected]

Abstract: A novel Schiff base 6-methyl-3-((quinolin-3-ylimno) methyl)-4H-chromen-4-one obtained by the condensation of 3-formyl-6-methylchromone and 3-aminoquinoline and synthesis of its Cu(II) and Co(II) complexes. Schiff base and its complexes have been characterized by analytical data, elemental analysis, molar conductance, magnetic moment and thermogravimetric analysis. The structural elucidation of prepared compounds carried out by UV-Visible, infrared 1HNMR spectroscopic techniques. The elemental analysis revealed metal to ligand stoichiometry was 1:2. Spectroscopic studies and magnetic moment data interpret octahedral geometry of the complexes. The measured low molar conductance values in DMF indicate that complexes are non-electrolyte. The synthesized compounds were evaluated by in vitro antimicrobial analysis and results were compared with standard tetracycline. Schiff base and its metal complexes shown remarkable antibacterial and antifungal activity.

Keywords: Schiff base, Antimicrobial activity, 3-Aminoquinoline, 3-Formyl-6-methylchromone. PP- 101

Synthesis of Silver Nanoplates its Characterization and Optical Properties

Dr. Ashish. A. Rokade1, Prof. Seong Soo Park2, Dr. D. D. Gaikwad1*

1 Govt College of Science Aurangabad, Maharashtra, India. 2 Pukyong National University, Busan, South-Korea.

*Corresponding author:[email protected]

Abstract: Ag nanoplates were synthesized by reducing silver nitrate (AgNO3) with poly (vinyl pyrrolidone) as reducing and stabilizing agent and citrate as shape regulating agent. Morphologies of the synthesized Ag nanoplates were investigated using transmission electron microscopy (TEM) and field emission scanning electron microscopy (FESEM,). Samples were prepared by placing a drop of Ag nanoplate solution on the carbon-coated copper grid and left dry at room temperature. SEM and AFM samples were prepared by placing a drop of Ag nanoplate solution on the silicon wafer and dried at room temperature. UV-Vis-NIR spectra were check at room temperature using spectrophotometer. The reflectance and absorption spectra of thin films of Ag nanoplates were further studied by applying then on PET substrate.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 84 Exploring New Horizons in Chemical Sciences-2019

PP- 102 Ammonium chloride: An efficient catalyst for one pot multicomponent synthesis of tetrasubstitutedimidazoles under MW irradiation. Sandip S. Shelke, Shubham S. Shende, Rushikesh G. Vitnor, Shivaji S. Pandit*, aResearch Centre and Post Graduate Department of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce Pravaranagar, Lonikd. Tal. Rahata. Dist. Ahmednagar 413713. (MS). India. *Corresponding author: [email protected] Abstract: Imidazole was prepared in 1858 by debus. Imidazoles have received significant attention of researchers due to their biochemical properties. The imidazoles are one of the most important structures found in a large number of natural products and pharmacologically active compounds. Recently, the application of imidazoles as ionic liquids referred as green catalyst. The synthesis of 1, 2, 4, 5-tetrasubstituted imidazoles was done by several ways as: N-alkylation of trisubstitutedimidazoles, condensation of β- carbonyl-N-acyl-N-alkylamines with ammonium acetate and by hetero-cope rearrangement. Also, tetrasubstitutedimidazoles can be prepared by MCRs of diones, aldehydes, primary amines and ammonium acetate. In the four-component reaction proceeds with low yields, use of hazardous, toxic, and expensive reagent, long reaction time, side reactions, moderate yield. Therefore, the development of a new catalytic system to overcome these shortcomings and fulfill the criteria of green chemistry protocol for the synthesis of highly substituted imidazoles is an important task. In the present work we report the catalytic role of ammonium chloride for one pot MCRs for the synthesis of tetrasubstitutedimidazoles under microwave irradiation. PP-103 Guanidine carbonate: An Efficient Catalyst for Knoevenagel condensation of Barbituric acid and Aryl Aldehydes.

Rushikesh G. Vitnor, Sandip S. Shelke, Shubham S. Shende, Shivaji S. Pandit* aResearch Centre and Post Graduate Department of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce Pravaranagar, Lonikd. Tal. Rahata. Dist. Ahmednagar. 413713 (MS). India. *Corresponding author: [email protected]

Abstract: Barbituric acid, strong acid in aqueous medium which easily undergoes Knoevenagel condensation reaction with aldehydes or ketones to produce 5-arilidine barbiturates, it acts as central nervous system depressants. The derivatives of barbituric acid have plays important role in pharmaceutical chemistry. Their biological activities range from classical applications in medical treatments as sedative, hypnotic, anticonvulsant, antiplasmodic and local anaesthetic drugs. In addition to these kinds of application, some of these derivatives have been investigated as non‐linear optical materials and dyes. Numerous synthetic method have been reported by solvent free grinding, using NH2SO3H, MW irradiation, IL mediated condensation, and uses variety of catalysts such as ZnCl2, CdI2, NiSiO2, KFAl2O3, BiCl3,L-proline, basic alumina,CuO-NP, SiO2.12WO3.24H2O, DBSA,natural phosphate and synthetic phosphate, dry condensation with acidic clay catalysts, Ni nanoparticles and CoFe2O4 nanoparticles etc. However these methods are plagued by limitation of longer reaction time, effluent pollution, bis-addition and self condensation, lower yields, and use of hazardous organic solvents. The present methodology offers several advantages and makes the process environmentally benign.

O H O H O Guanidine Carbonate Ar N N (5 mol%) + O O Ar H Solvent free, RT N N Stone Grinding O H O H

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 85 Exploring New Horizons in Chemical Sciences-2019

PP- 104 Potentiometric study of complexation of Labetalol drug with transition metal ions in 20 %(v/v) ethanol-water mixture Ramesh Ware1, M. A. Sakhare2, Shailendrasingh Thakur1 1Department of Chemistry, Milliya College, Beed. 2Department of Chemistry, Balbhim College, Beed.

*Corresponding author: [email protected], [email protected] Abstract: In the present work we investigate the stability constant of Labetalol hydrochloride drug with transition metal ions Co, Ni, Cu, Zn, and Cd using potentiometric titration technique in 20%(v/v) ethanol-water mixture at 27ºC temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand ratio=1:5 & 1:1}The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton ligand (pKa) and metal-ligand stability constant (logK) values. It is observed that a transition metal ion forms 1:1 and 1:2 complexes.

O NH2

OH

.HCl

NH

OH PP- 105

Condition based divergence in the synthesis of 3-Indole derivative by using choline hydroxide

Amol U. Khandebharad, Swapnil R. Sarda, Kishor N. Tapdiya, Arvind R. Mahajan, Brijmohan R. Agrawal* Department of Chemistry, J. E. S. College, Jalna,(MS) India. . *Corresponding author: [email protected]

Abstract: A simple, efficient and straightforward three components one pot synthesis of biologically important and highly potent 3-Indole derivatives has been described by condition based divergence approach. The target molecule has been rationalized via tandem reaction of aldehyde, malononitrile and indole in the presence of choline hydroxide. Use of minimum amount of water shown a dramatic effect on the diffusion of ions and forms the micro heterogeneous system by water depleted Ionic liquid media. Energy efficiency, high atom economy and metal free synthesis and eco-friendliness are the distinguishing features of this newly developed protocol. R

O CN CN Ch-OH: Warter CN CN N R H 40°C N H

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 86 Exploring New Horizons in Chemical Sciences-2019

PP-106

Synthesis, Characterisation and In-Vitro Biological Activities of Co (Ii) Complexes of 2-(4-methaylbenzylideneamino) Pyrimidine-4, 6-Diol D. T. Sakharea, B.K. Magareb, A. G. Shankarwarc a,b U.G. & P.G. Department of Chemistry, Shivaji , Art’s, Comm. & Science College Kannad. c U.G. & P.G. Department of Chemistry, S.B.E.S. College of Science, Aurangabad.

*Corresponding author:[email protected] Abstract: The transition metal complex of Co (II) was prepared from bidentate Schiff base. The Schiff base ligand 2-(4-methaylbenzylideneamino) pyrimidine-4, 6-diol (L4) derived from the condensation of P- methylbenzaldehyde and 2-amino -4,6 dihydroxypyrimidine in alcohol medium. These metal complexes were characterized on the basis of their micro analytical data, molar conductance, magnetic susceptibility, IR, UV-Vis, 1H NMR, X-ray diffraction, therogravimetric analysis. The ligand and their metal complexes were screened for fungicidal activity against various fungi like Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergllus flavus and antibacterial activity against various bacteria like Escherichia coli, Salmonellatyphi, Staphylococcus aurious, B.subtilis. The result indicated that the complexes exhibited good antifungal and antibacterial activities.

Keywords: Schiff bases, Transition metal complexes, Thermal analysis, Powder X-ray diffraction, Antimicrobial activity. PP- 107 Synthesis, Characterization and Antimicrobial Studies of some Lanthanide Metal Complexes of Tetradented Ligand S. M. Jadhav1, V. A. Shelke2, S. G. Shankarwar3

2Department of Chemistry, Siddharth Art, Science and Commerce College Jafrabad Dist. Jalna-431206, India Department of Chemistry, Indraraj Arts, Science and Commerce College Sillod Dist. Aurangabad-431112, India 4Department of Chemistry, Dr.Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, India

*Corresponding author:[email protected]

Abstract: The solid complexes of La(III), Ce(III), Pr(III), Nd(III), Sm(III) and Gd(III) have been synthesized from 4-mehyl–o-phenylenediamine, 3-Acetyl 6-methyl-pyran-2,4-dione and 2-hydroxy benzaldehyde and characterized by spectral and other physicochemical techniques such as 1H-NMR, UV-vis molar conductivity, magnetic susceptibility, thermal analysis, X-ray diffraction, FTIR, and mass spectroscopy. The analytical data of these metal complexes showed metal: ligand ratio (1:1).). The IR spectral data reveal that the ligand behaves as dibasic tetradented ligand with ONNO donor atom sequence towards central metal ion. The molar conductance values of metal complexes suggest their non electrolyte nature. The x-ray diffraction data suggest orthorombic crystal system for La(III) complex and orthomboic crystal system for Ce(III) complex. Thermal behavior (TG/DTA) and kinetic parameters calculated by Coats-Redfern method are suggestive of more ordered activated state in complex formation. The ligand and their metal complexes were screened for antibacterial activity against Staphylococcus aureus and Escherichia coli and fungicidal activity against Aspergillus Niger and Trichoderma.

Keywords: Schiff base, Metal complexes, Thermal analysis, XRD, Antimicrobial study.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 87 Exploring New Horizons in Chemical Sciences-2019

PP- 108

Environmentally-benign Synthesis of Silver Nanoparticles and their Optical and Catalytic properties

Dr. Ashish. A. Rokade, Prof. Park Seong Soo, Prof. R.P. Pawar, Dr. M. B. Swami.

1Hu. Bahirji Smarak Mahavidyalaya- Basmatnagar, Hingoli, Maharashtra* 2Pukyong National University, Busan, South-Korea. 3 Deogiri College of science, Aurangabad, Maharashtra.

*Corresponding author: [email protected]

Abstract: Silver nanoparticles receive significant attention due its versatile physical and chemical properties. In this work, we report green-synthetic method for synthesis of Ag nanoparticles. Cinnomani extract was used to synthesize Ag nanoparticles. The Ag nanoparticles were synthesized by UV-spectrophotometer, TEM, SEM and XRD analysis. The characteristics UV absorbance was observed at 400 nm and above for Ag nanoparticles. These Ag nanoparticles catalytic activities were investigated for 4-nitrophenol reduction.

PP- 109

Ultrasonic Irradiation: Synthesis, Characterization, and Primary Antibacterial Activity of Novel series of 1, 3, 5-triazine Derivatives Containing Thymol Moiety

A. A. Patil 1 S. R. Patil 1 1PG & Research Department of Chemistry, MGSM A.C.S. College, Chopda, Dist.-Jalgaon *Corresponding author: [email protected], [email protected]

Abstract: Considerable interest has been attracted in s-triazine scaffold and its derivatives because of their large variety of pharmacological activities. In this study, novel series of 1, 3, 5-triazines containing thymol derivatives were synthesized employing ultrasonic irradiation. The ultrasonication gave the target products in higher yields and purity in shorter reaction time. IR and NMR confirmed the structures of the new products. The antibacterial activity was evaluated for all the prepared compounds against some selected Gram-positive and Gram-negative bacterial strains.

Keywords: S-Triazine, Thymol, Ultrasonication, Antibacterial activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 88 Exploring New Horizons in Chemical Sciences-2019

PP- 110

A Study on The Synthesis And Anti-Microbial Activity Of Some New Ethylenediamine Bis-Schiff Bases Ligands and Metal Coplexes

Chandrakant V. Magar

Department of Chemistry, Sant Tukaram College of Arts and Science Parbhani, 431401 (MS)

*Corresponding author: [email protected]

Abstract: A number of transition metal complexes of Ni (II), Cu (II) And Zn (II) with bi-dentate ligand, Bis-(4- Hydroxy -3 Methoxy -5-Benzylidene ethylenediamine) were prepared in Methanol Separately in stoicheometric proportion1;2 together, Mixture was reflex for 6 hours , Adjust the PH of solution 7-8 by using alcoholic ammonia solution. The metal Complexes has been characterized on the basis of elemental analysis, conductance .The ligand and metal complexes were screened for their Antimicrobial activities against Escherichia Coli, Stphylococcus Aureus, Salmonella Typhi.

Keywords: Schiff Bases, Ligands, Metal Coplexes, Anti-microbial activity.

PP-111 Review on different recent methods for synthesis of some tetrazoles and different biological activities

Jagdish B. Musmadea, Kabeer Shaikhb, Priyali B. Darandalea, Jayashree R. Kakadea, Yogesh B. Salvea, Nitin D. Bhogec, Mahesh M. Jangalea, Vishal M. Pawara.

aP.G. Department of Chemistry, Arts, Commerce and Science College, Sonai bP.G. Department of Chemistry, Sir Sayyad College, Roshangate, Aurangabad cP.G. Department of Chemistry, ShriDnyaneshwarMahavidyalay, Newasa.

*Corresponding author: [email protected]

Abstract: This review includes several recent methods for synthesis of tetrazoles like integrating multicomponent Ugi-azide reaction with the molecular hybridization approach, using tributyltinchloride in presence of sodium azide, using sodium azide and triethylorthoformate with aromatic amines in glacial acetic acid, aryl tetrazole amines via desulphurization/substitution/electro cyclization/C-N cross coupling reactions from thiourea with the use of cheap, readily available and air stable copper source as catalyst, carboranyltetrazoles, using various nitriles and sodium azide in the presence of urea and acetic acid, using the azido- Ugi reaction. Also some tetrazole containing ligands complexes can be synthesized, also tetrazole amides. Which showed broad-spectrum of biological properties including anti-tubercular and anti-malarial activities, and some tetrazole-based compounds have already been used in clinics for the treatment of various diseases like Alzheimers's disease, antileukemic activity against an extensive panel of human cancer cell lines, MV4-11 AML cell line, and antileishmanial activities, anti- allergic/anti-asthmatic, and anti-inflammatory, anti-neoplastic activities, antimicrobial activity anti- inflammatory activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 89 Exploring New Horizons in Chemical Sciences-2019

PP- 112

Silica Supported Polyphosphoric Acid Catalyzed Synthesis of Substituted Indazole Raut S .V.*1. Dhotre B. K2. More S P3. Tidke A D1. Pathan Mohd Arif1

1Maulana Azad College and Research Center Rouza Bagh Aurangabad (M.S.) India. 2Swami Vivekanand Sr. College Mantha, Jalna (M.S.) India. 3Late. Ku. Durga K. Banmeru Science College Lonar (M.S.) India.

*Corresponding author: [email protected] Abstract: A simple and clean methodology developed for the synthesis of substituted indazoles using silica supported polyphosphoric acid (PPA-SiO2) catalyzed condensation reaction between substituted 2- hydroxy benzaldehydes or acetophenones and hydrazine hydrate or phenylhydrazine. The reaction conditions are optimized for different solvents at different temperatures. The yield of the products improved to 88 to 90 % using silica supported polyphosphoric acid as catalyst which is reusable, cost effective and simple to synthesize.

R3 R R3 O 2 PPA-SiO2 (Cat.) R4 R4 R2 Solvent N + NH2-NHR1 R N R OH 5 5 2 R1 1 3a-l PP- 113

Synthesis and Characterization of New Schiff Bases Derived from Substituted Salicylaldehyde with m-Xylylene Diamine and their Biological Activity

Lande A.A.1, Kolapwar B.G.1, Karamunge K.G.2

1Department of Chemistry, Shri Renukadevi Arts, Commerce and Science Mahavidyalaya, Mahur. 2Department of Chemistry, Baliram Patil College, Kinwat.

*Corresponding author: [email protected]

Abstract: The new series of Schiff bases were synthesized by reacting substituted Salicylaldehyde with m- Xylylene diamine and Acetic acid under reflux. The title compound have been characterized by spectral techniques IR,1HNMR,C13 and Mass spectral data. The synthesized compound were evaluated for their qualitative antibacterial and antifungal activity by agar method respectively. In general the title compounds have shown mild to moderate anti bacterial and antifungal activity.

Keywords: m- Xylylene diamine, Characterization, Anti bacterial and antifungal activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 90 Exploring New Horizons in Chemical Sciences-2019

PP- 114 BF3.CH3CN as a novel catalyst for one pot solvent free synthesis of Pyrazole derivatives N. H. Mutkule1, N. V. Bugad1, S. N. Mokale2, M. B. Ubale1* 1Department of Chemistry, Vasantrao Naik Mahavidyalya, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, India 2Department of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad-431 004, India *Corresponding author: [email protected]

Abstract: Solvent free synthesis is receiving tremendous attention in recent times and is an integral part of research especially in green synthesis. Development of catalyst and establishing a new catalyst in synthesis is also the current trend of research. BF3.CH3CN is one of such rarely explored catalyst. The BF3.CH3CN has been found as an efficient effective catalyst for synthesis of substituted in pyrazole. It is first report of combination of BF3.CH3CN in solvent free reaction condition to yield Pyrazole derivatives. The main advantage of this protocol is establishing BF3.CH3CN as a catalyst, shorter reaction time, high atom economy and simple work-up procedure.

CN CHO HN NH2 H2N

CN N BF3.CH3CN N R CN Solvent Free R 1a-l 2 3 4a-l

Keywords: BF3.CH3CN, Pyrazole, Green synthesis, Solvent Free, Atom economy PP- 115 Novel designed for Silica supported Al@ZnO Nanoparticles by Sol – Gel Method R. M. Tigote*a, S. K. Kazi a, A. A. Malkharea, K. P. Havala, D. P. Kambleb aDepartment of Chemistry, Dr. B.A.M. University Subcampus Osmanabad-413510 (MS) bDepartment of Chemistry, S. B.E.S. College of Science Aurangabad-431002. *Corresponding author: [email protected], [email protected]

Abstract: Currently, herein designed newly silica supported Al@ZnO nanoparticles & their processing technique as using sol-gel method at room temperature. The synthesized nanoparticles are amorphous& their other property has been studied such as optical properties, particle size, conductivity etc. The optical properties of synthesized nanomaterial were studied using UV – Visible spectrometer with the wavelength as 295 nm .The particle size of sample as 56nm were calculated by using X – Ray Diffraction technique.

8000

7000 Smp Al@ZnO@SiO 2

6000 7 samp 1 5000 6 samp 2 samp 3 5 4000

Intencity 4 3000

3 Absorbance 2000 2

1000 1

0 0 0 10 20 30 40 50 60 70 80 90 240 260 280 300 320 340 360 2 Theta Wavwlwngth

Fig.: XRD of Al@ZnO Nanoparticles Fig.: UV of Al@ZnO Nanoparticles

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 91 Exploring New Horizons in Chemical Sciences-2019

PP-116 Efficient Knoevenagel Condensation Reaction catalyzed by activated Zinc based Metal organic Framework. V. N. Rathod, M. K. Lande Department of Chemistry, Dr.Babasaheb Ambedkar Marathwada University, Aurangabad. *Corresponding author: [email protected]

Abstract: A porous co-ordination solid of Zinc(II) pyridine 2,5 dicarboxylic acid has been synthesized by the solvothermal method. The synthesized Zinc(II) pyridine 2,5 dicarboxylic acid was designated by the general formula [Zn3(pydc)2(OH)2(H2O)2]n .Metal organic framework used as an efficient heterogeneous acid catalyst. MOF-catalyzed reaction and summarize catalytic center, including the open metal site, bifuctional acid- base site. Zinc based metal organic framework catalyst termed Zn(pydc) ( pydc = Pyridine 2,5 dicarboxylic acid) MOF was successful applied to the synthesis of the Knoevenagel Condensation Reaction between malononitrile and aldehyde to form malononitrile-derivatives under the reflex condition .The remarkable catalytic activity of Zn(pydc) MOF was proven by the successful synthesis of Knoevenagel reaction in high yield. The solid acid catalyst was characterized using variety of different technique, including X-ray diffraction (XRD), Therogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), BET.

PP-117

Extraction of phytochemicals and study of its antimicrobial activity from Phyllanthus Niruri L.

S. P. Mahire, Dr. S. N. Patel

S. P. D. M. College, Shirpur, Dist. Dhule, Maharashtra, India.

*Corresponding author:[email protected]

Abstract: Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytodrugs and some medicinal herbs have proven hepatotprotective potential. The present paper deals with the phytochemical screening of therapeutic importance from Phyllanthus Niruri L., an important medicinal plant. Phyllanthus niruri originated in India, usually occurring as a winter weed throughout the hotter parts. The Phyllanthus genus contains over 600 species of shrubs, trees and annual or biennial herbs distributed throughout the tropical and subtropical areas. This study involves the preliminary screening; Results show that nine of thirteen phytochemicals screened for were present. They are; alkaloid, cardiac glycosides, carbohydrate, flavonoids, phenols, saponins. The plant extracts showed antibacterial activity and antifungal activity against bacteria and fungi used. Further studies are required in order to isolate the active components from the crude plant extracts for proper drug development.

Keywords: Phytochemicals, extract, Phyllanthus Niruri L., Antimicrobial

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 92 Exploring New Horizons in Chemical Sciences-2019

PP-118 Synthesis, characterization and antimicrobial activity of metal complexes of Mn(II), Ni(II), and Cu(II) with derivatives of 4-(5-methyl-1H-tetrazol-1- yl)benzenamine as new ligands

Rajkumar G. Momle,1 Suresh G. Vedpathak,2Prashant P. Dixit,3Gopal K. Kakade4 1Late Shankarrao Gutte ACS College Dharmapuri, Maharashtra, 431 515 India. 2Department of Chemistry, S. M. Dnyandeo Mohekar College, Kallam, 413 507 (MH), India 3Department of Microbiology, Dr. B. A. Marathwada University, Sub-Campus Osmanabad 413501 (MH), India 4Department of Chemistry, MSP Mandal’s ASC College, Kille-Dharur, 431 124 (MH), India *Corresponding author: [email protected]

ABSTRACT: Ni(II), Cu(II), and Mn(II) complexes synthesized from novel Schiff bases of 4-(5-methyl-1H-tetrazol-1- yl)benzenamine and salicyaldehyde in hot alcoholic solution. The synthesized complexes were characterized by FTIR spectroscopy, UV-visible spectroscopy, X-ray defraction and thermal studies. The octahedral geometry of complexes was confirmed by electronic spectra and thermo gravimetric analysis. Furthermore, the complexes were subjected for their antimicrobial screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Ni(II) complexes were found significant antibacterial activity with an MIC of 17 µg/ml compared with standard tetracycline (20 µg/ml) while Mn(II) complex has shown noticeable antibacterial activity at the same concentration. Antifungal activity of the ligand has enhanced on complexation with Cu(II) and Ni(II) ions, while Mn(II) complexes shows superior antifungal activity than the other complexes.

PP- 119 β-cyclodextrin in Water (β-CD/H2O):An Efficient and Recyclable Catalyst for the Rapid Synthesis of (E)-2-amino-N-(2-benzylidenehydrazinecarbonothioyl) benzamides Amol S. Nipate, Chetan K. Jadhav , Asha V. Chate, Charansingh H. Gill*

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, M.S., India. Fax: +01 240 2400491, Phone No. +91 240 2403311.

*Corresponding author: [email protected]

Abstract: Quinazoline and its derivatives are an important class of heterocyclic compounds, which have attracted a considerable attention for their anti-cancer activity,1 and have also been tested for their potential biological and pharmacological activities, for example anti-hypertensive,2 anti-tumor,3 anti- inflammatory,4 and anti-bacterial activity, Hence, the synthesis of Quinazoline derivatives is currently of great interest both in organic synthesis and medicinal chemistry.3 Due to the importance of such activities of these compounds, the synthesis of quinazolinone and its derivatives. In this work, we developed a new green protocol which is efficient and environmental benign catalyst β-CD for the synthesis novel hybrid Synthesis of (E)-2-amino-N-(2-benzylidenehydrazinecarbonothioyl) benzamide.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 93 Exploring New Horizons in Chemical Sciences-2019

PP- 120 A Review on Various Applications of Drugs in Research Field

Jyoti M. Weldode1, Changdev V. Mane1, Arjun V. Nakhate2, Satish A. Dake1* 1Department of Engineering Chemistry, Deogiri Institute of Engineering and Management Studies, Station Road, Aurangabad-431005, (MS), India 2Department of Engineering Chemistry, Marathwada Institute of Technology, Beed by pass Road, Aurangabad-431028, (MS), India *Corresponding author:[email protected] Abstract: Drug innovation is very important process in the various fields such as Pharmacology, Biology, Organic Chemistry, Analytical Chemistry, Polymer Chemistry, Medicinal Chemistry, Biotechnology, and Nanotechnology. Drugs play an important role in the life of human beings and other living organisms. Drugs and their metal complexes provide opportunities for building structures. Various types of diseases and their treatment are based on the metabolism of inorganic constituents. To enhance the biological activity of drugs molecules coordination compounds can be used. Literature Survey reveals that, as compared to the parent drug the complexes of metallic salts are more effective and less toxic. Some inorganic based drugs are acts as anti-tumor, anti-arthritic and antidepressants. This paper reviews on various applications of drugs in research field.

PP-121 A novel one-pot three component efficient synthesis of α-aminophosphonates using phosphonium ionic liquid Sunil K. Wasmatkara, Swapnil R. Sardab, Rashmi D. Pathrikrc, Suresh D. Kulkarnid, Rajendra P. Pawar a* aDepartment of Chemistry, Deogiri College, Aurangabad, (MS) India. bDepartment of Chemistry, J. E. S. College, Jalna, (MS) India. cRajeshree Shau Arts Commerce and Science college, Pathri, (MS) India. dMaharashtra Mahavidyala, Nilanga, (MS) India. *Corresponding author:[email protected] Abstract: The α-aminophosphonates are pharmacologically active substances displaying a broad range of biological activity. Their synthesis has been received considerable interest because of their structural similarity to α-amino acids. Herein we describe a simple and convenient method for the synthesis of α- aminophosphonates using tetradecyl-(trihexyl)-phosphonium-chloride ionic liquid [PhosIL-Cl] at room temperature in excellent yields with short reaction time. The mixture of aldehyde (1 mmol), amine (1 mmol), diethylphosphite (1 mmol) and tetradecyl- (trihexyl)-phosphonium-chloride [PhosIL-Cl] ionic liquid (2 ml) was added in 50 ml round bottom flask and the contents were stirred at room temperature for the appropriate time. After completion of reaction water and hexane (5+5 ml) were added to the reaction mixture which resulted in the formation of a three-phase system, organic layer on the top, ionic liquid in the middle, and the aqueous layer at the bottom. The product was isolated from the organic layer by successive extractions. Ionic liquid was washed with water and hexane, dried and reused several times to carry out the same experiment. CHO H H Ionic Liquid N R2 R1 P [PhosIL-Cl] R NH P 1 2 EtO OEt RT R O EtO OEt 2 O [Scheme-I]

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 94 Exploring New Horizons in Chemical Sciences-2019

PP-122 Synthesis of Vanadium, Niobium and Tantalum doped TiO2 and investigation of its photocatalytic performance Shrinivas Motekara,* and Sudhir S. Arbujb aDepartment of Chemistry, Sunderrao Solanke Mahavidyalaya, Majalgaon, Beed-431131, India bMaterials for Renewable Energy and Sensors Division, Centre for Materials for Electronics Technology, off Pashan Road, Panchwati, Pune-411008, India.

*Corresponding author:[email protected] / [email protected] Abstract: Herein, the synthesis of metal (V, Nb and Ta) doped TiO2 nanostructures have been synthesized using solid-state route with doping concentration 0.1 and 1 mol%. The prepared nanostructures were analyzed with different spectroscopic techniques and studied its photocatalytic activity towards methylene blue (MB) dye degradation. XRD indicate the existence of anatase phase of TiO2 with 0.1 and 1 mol% doping of V, Nb and Ta respectively. The diffuse reflectance absorbance spectra of V doped TiO2 shows red shift in the absorbance profile while the Nb and Ta doped TiO2 does not showed any marginal change. FE-SEM analysis indicates the formation of distorted spherical morphology having size in the range of 50 to 100 nm. TEM analysis validates the FE-SEM results and indicates the spherical shaped particles. The photocatalytic activity of V, Nb and Ta doped TiO2 towards aqueous MB degradation shows enhanced photocatalytic activity as compared to pristine TiO2, V2O5 Nb2O5 and Ta2O5 respectively. Among the prepared compositions the Nb doped TiO2 with 0.1 mol% doping shows highest photocatalytic MB degradation.

PP- 123

Synthesis of Benzimidazole Derivatives Using Recyclable Ionic Liquid at Room Temperatutre Dr. Sangita Sanjay Makone* and Naushaba Tazeen

School of Chemical Sciences, S. R. T. M.University, Nanded-431606 Maharashtra. India.

*Corresponding author: [email protected] Abstract: The new method of synthesis of benzimidazole derivatives by a mixture of o- phynylenediamine with substituted aldehydes was stirred at room temperature in the solution of ethanol, catalysed by ionic liquid. The structure of the novel benzimidazole compounds were confirmed by various spectroscopic analysis and further tested for its biological activity. To overcome the drawbacks of chemical method there is growing demand for the development of organic reactions in environment friendly conditions. This method has several advantages such as simple work-up procedure, involving short reaction time, high yields of the product formation, eco-friendly and reusability of catalyst.

Keywords: Ionic liquid, Benzimidazole, o- phenylenediamine, Ethanol O

NH2 N R H IL + EtOH R + RT N NH2 H

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 95 Exploring New Horizons in Chemical Sciences-2019

PP- 124 Cellulose acetate blended Poly (vinylidene fluoride) PVDF membrane with ionic liquid and their hydrophilicity measurement for treatment of textile industry waste Hrishikesh Sarmah, Monti Gogoi, Rajiv Goswami, Swapnali Hazarika* Chemical Engineering Group, Engineering Science & Technology Division, CSIR-North East Institute of Science and Technology. *Corresponding author: [email protected]

Abstract: Poly(vinylidene fluoride) (PVDF) membranes have immense application in the recent membrane research and industrial process as it possess exceptional properties such as high thermal stability, good chemical resistance and membrane forming properties. Phase inversion via immersion precipitation is the most widely used membrane preparation method for PVDF membrane. The interest in ionic liquids (IL) is considered for its unique properties, such as thermal stability, wide electrochemical stability and tunability of properties. ILs has been highlighted as solvents for liquid membrane separation besides other application such as liquid-liquid extraction, organic synthesis etc. In view of this our aim is to develop PVDF/ILM membranes for waste water treatment. We have prepared PVDF membrane blended with cellulose acetate (CA) and IL namely 1-hexyl-3-methylimidazolium tetrafluoroborate and Polyethylene glycol as the additives. The contact angle for each of the membranes was evaluated using the sessile drop method which gave an insight about the membrane surface properties. It was observed that due to the addition of CA and IL, the membranes become hydrophilic. Apparently, the concentration ratio of both CA and IL performs a crucial role in aggravating the hydrophilicity of the membrane and the lowest contact angle recorded was 43°. The membrane has been tested for the treatment of waste water of textile industries and observed appreciable results for dye rejection.

Keywords: Ionic liquid, Contact angle, hydrophilicity, cellulose acetate PP-125 Ionic Liquid Catalysed Synthesis of New 1, 5-Benzothiazepines Dr.Mrs.Sangita Sanjay Makone*, Miss. Priyanka Sunil Pinate

School of Chemical Sciences, S.R.T.M.University, Nanded-431606.Maharashtra.India. *Corresponding author: [email protected] Abstract: The Compounds bearing 1,5-bezothiazepine moiety has stimulated interest in developing new synthetic protocols for their synthesis due to its broad spectrum of biological activities. The most utilized route to 1,5-bezothiazepines is via the reaction of 2-aminothiophenols with chalcone which proceeds through the thia-Michael addition of the thiol group to the enone functionally of the chalcone to form the intermediate followed by the cyclization of this intermediate to 1,5-bezothiazepine. Various synthetic 1, 5-bezothiazepine have been reported to possess useful biological activities such as antimicrobial, antitumor. Some are used as anti-cancer, antifungal, anti-HIV, antibacterial. In the present study we synthesized 1,5-bezothiazepines by condensation of 2-aminothiophenol with novel chalcones catalyzed by Dicationic acidic organic salt (MCAOS) i.e. Ionic Liquid. The reuse of the Ionic Liquid is a major factor in a new synthetic green procedure. Used ionic liquids were recovered after absorption either by washing with water followed by drying or by distillation. This environmentally friendly methodology with excellent green chemistry credentials, such as atom economy, use of non-toxic, thermally stable ionic liquid and shorter reaction time without any by-product.

Keywords: 2-Aminothiophenols, Chalcone, Dicationic acidic organic salt (DCAOS), 1, 5- bezothiazepine

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 96 Exploring New Horizons in Chemical Sciences-2019

PP-126

Synthesis of Benzthiazole Derivatives by Using Dicationic Ionic Liquid

Miss. Priyanka Sunil Pinate Dr.Mrs.Sangita Sanjay Makone*, Navashaba Tazeen

School of Chemical Sciences, S.R.T.M.University, Nanded-431606.Maharashtra.India.

*Corresponding author: [email protected]

Abstract: Nowadays Ionic Liquids have gained importance in several organic transformations due to their interesting reactivity also for economic and environmental reasons. In continuation of our work to develop greener alternatives for organic transformations, organic reactions in Ionic Liquid have attracted interest as green alternative and environmentally benign conditions. In the present study we synthesized bezthiazole derivative by condensation of 2-aminothiophenol with benzaldehyde catalyzed by Dicationic Ionic Liquid (DIL) as a catalyst. Various synthetic bezthiazole have been reported to possess useful biological activities such as antimicrobial, antitumour, anti-cancer, antibacterial. The present methodology has advantages like catalyst reusability, high yield of product, short reaction time, and simple workup procedure. Keywords: 2-Aminothiophenol, Benzaldehyde, Dicationic Ionic Liquid, bezothiozole PP- 127

Performance Evaluation of Membrane for isomeric separation of DL-alanine Monti Gogoia,b, Rajiv Goswamia,b, Hrishikesh Sarmaha, Swapnali Hazarikaa,b* aChemical Engineering Group, Engineering Science & Technology Division aCSIR-North East Institute of Science and Technology bAcademy of Scientific and Innovative Research, CSIR-NEIST Campus, India.

*Corresponding author: [email protected] Abstract: Chiral compounds are very much essential for biological systems and the effect of enantiomers may vary because of the stereoselective nature of the enzymatically catalyzed reactions inside the body. Homochiral compounds react with each racemic drug separately and stabilize each isomer by a different pathway to give a separate pharmacological output. The effectiveness and safe use of varying bioactive chiral compounds are possible if they are available in pure and optically active forms. The use of the membrane for chiral separation propounds various advantages such as continuous and high-efficiency resolution, cost-effective and relatively simple operation technique. Alanine plays a vital role in the different metabolic processes that take place in the body. When synthesized in the laboratory, alanine is available as DL mixtures in most of the times. So it is very important to resolve the mixture into separate components prior to its application In view of this, thin film membrane was developed from a condensation product of glutaraldehyde and amino acid, studied the adsorption and permeation of alanine isomers separately. The adsorption behavior of the isomers on to the membrane was investigated through equilibrium adsorption isotherms and relevant kinetic data for the adsorption process was investigated. Apparently, the optical resolution of the membrane was studied by performing permeation experiment and observed the enantioselectivity over more than 98%.

Keywords: Chiral moiety; Polymeric membrane; Interaction energy; Chiral resolution; Enantiomeric excess

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 97 Exploring New Horizons in Chemical Sciences-2019

PP- 128

Tartaric Acid: An Efficient, Catalyst for the Synthesis of Trisubstituted Imidazole under Microwave Irradiation

Sachin R. Kolsepatil1, S. Chandole2, Satish U. Deshmukh3, Dinesh L. Lingampalle1* 1Department of chemistry, Vivekananad College, Aurangabad, Maharashtra, India. 2Department of Chemistry, S. G. B. College, Purna (Jn.) Parbhani, Maharashtra, India. 3Department of chemistry, Deogiri College, Aurangabad, Maharashtra, India.

*Corresponding author:[email protected]

Abstract: An efficient for synthesis of trisubstituted imidazole from benzil/benzoin, aromatic aldehyde and ammonium acetate in water under microwave irradiation. Tartaric acid is an inexpensive mild catalyst and the remarkable advantages such as mild reaction condition, shorter reaction time, simple procedure and excellent yield.

Keywords: Trisubstituted imidazole, Tartaric acid, Water, microwave irradiation.

PP- 129 Preparation and performance evaluation of nanoparticles incorporated membrane for removal of Crystal violet dye

Rajiv Goswamia,b, Monti Gogoia,b, Hirok Jyoti Boraha, Hrishikesh Sarmaha, Pravin G. Ingolea, Swapnali Hazarikaa,b* aChemical Engineering Group, Engineering Science & Technology Division aCSIR-North East Institute of Science and Technology bAcademy of Scientific and Innovative Research, CSIR-NEIST Campus, India.

*Corresponding author: [email protected]

Abstract: Process effluents from pharmaceutical, textiles, papers, plastics, cosmetics industries contain dyes as the major contaminant with other organic components in aqueous form and this is an unprecedented problem worldwide. Membranes preferentially play a crucial role in separation process in various industries. Nanoparticle incorporation in the polymeric membranes has gained widespread interest due to the remarkable changes in properties as compared with the pure polymeric membrane. The incorporation of Pd(0) nanoparticles into the polymeric membrane enhance the membrane performance in terms of permeability, selectivity, strength and antifouling nature due to increase in hydrophilicity. In this regard a polysulfone nanofiltration membrane containing Pd(0) nanoparticles has been developed to enhance the properties of the membrane in terms of flux, dye rejection, hydrophilicity, mechanical strength, antifouling and salt rejection. The performances of the membranes were evaluated using crystal violet dye. Nanoparticles incorporated polysulfone membranes showed improvement in various properties. The membrane containing 2% Pd(0) nanoparticles showed more hydrophilicity and dye rejection (99%) with breaking stress 7.85 mPa. Thus, the improvement in the properties of the nanocomposite membranes depends on the concentration of Pd(0) nanoparticles.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 98 Exploring New Horizons in Chemical Sciences-2019

PP- 130 Synthesis and antibacterial activity of pyrazole anchored Chalcones Mhaske S D 3, Salve S P1, Karale2 B K, Falke D B1, Ghungurde R D1 & S J Takate1* 1Department of Chemistry, New Arts, commerce and Science College, Ahmednagar, India, 414001. 2Shri Chhatrapati Shivaji College, Satara, India, 415001. 3Dada Patil Rajale college, Adinathnagar India.

*Corresponding author: [email protected] Abstract: Need of potential therapeutic agents is the basis for current research in synthetic organic chemistry. Nature contains widespread molecules with rings containing heteroatoms and provides key leads for drug discovery. Lead modification is an important step in current drug design and development. Recently pyrazole containing compounds have attracted researchers because of their wide applications in the field of medicines. Flavonoids belong to a large family of natural products which have been extensively studied for their biological potential. Chalcones are key precursors in flavonoid synthetic pathway. Chalcones are well known for their bioactivities including antibacterial, antitubercular, anti- inflammatory, antimalarial, antifungal and antiviral activities. In present study pyrazolyl chalcones were studied for their antibacterial activities against E. coli and B. subtilis. All the compounds were inactive against E. coli while some of them were promisingly active against B. subtilis at concentration of 2 mg/ml.

PP-131 Volumetric and Viscometric Behaviour of Acrylates with 2-Decanol

Sunil R. Mirgane** and Sujata S. Patil* ** P. G. Dept. of Chemistry, J. E. S. College, Jalna - 431 203, (M. S.), India. * Dept. of Applied Science, Matsyodari Shikshan Sansths’s College of Engineering & Technology, Jalna -431 203, (M. S.), India.

*Corresponding author: [email protected]

Abstract: Densities and viscosities for three binary liquid mixtures of methyl acrylate, ethyl acrylate and butyl acrylate with decane-2-ol at temperature 298.15 K and at atmospheric pressure were measured over the whole composition range. These values were used to calculate excess molar volumes (VE) and deviation in viscosities (∆η) which were fitted to Redlich-Kister polynomial equation. Recently proposed Jouyban Acree model was also used to correlate the experimental values of density and viscosity. The mixture viscosities are correlated using Hind, Choudhary-Katti, Grunberg-Nissan, Tamura and Kurata, Heric – Brewer, McAllister three and four body model equations. The calculated excess molar volume and deviation in viscosity were found to be positive and negative respectively for all the binary liquid mixtures at 298.15 K temperature. The typical variations in these properties of the binary liquid mixtures as a function of ester mole fraction are explained in terms of structure breaking dispersion. A graphical representation of excess molar volumes shows positive nature whereas deviation in viscosity shows negative nature at all temperatures for three binary liquid mixtures. Positive values show that volume expansion is taking place causing rupture of H-bonds in self associated alcohols. The results are discussed in terms of molecular interactions prevailing in the mixtures.

Keywords: Binary mixtures, Acrylic esters + decane-2-ol, Excess molar volume, Viscosity deviation, Jouyban Acree model.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 99 Exploring New Horizons in Chemical Sciences-2019

PP- 132

Efficient Knoevenagel Condensation catalyzed by Nickel Complexes

Manojkumar U. Chopadea*, Anil U. Chopadeb, Santosh V. Padghana aSant Dnyaneshwar Mahavidyalaya, Department of Chemistry, Soegaon, Dist: Aurangabad 431120 India bDahiwadi College, Dahiwadi, Rayat Shikshan Sansthan, Satara, Shivaji University Kolhapur 415508 India *Corresponding author: [email protected]

Abstract During recent years transition metal has found its way to the synthesis of biologically active natural product in organic synthesis.The continue internet to synthesis of biologically active compound we have plan for development ofNickel catalyzed novel methodology, Knoevenagel condensation of aldehyde with ethyl cyano acetate to provide Alpha cyano ethyl cinnamate. The corresponding adducts were obtained in good yields (78-92%) under simple and clean condition. CHO COOEt COOEt Ni(acac)2 CN CN DMSO R R 3 1 2 R = H, Cl, OMe, NO2, OH

PP- 133 Synthesis and Bioevaluation of Dimeric 1, 2, 3-Triazolyl Monocarbonyl Curcumin Analogues

Tejshri R. Deshmukh1, Vagolu S. Krishna2, Dharmarajan Sriram2, Jaiprakash N. Sangshetti3, Bapurao B. Shingate1,* 1Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, Maharashtra, India. 2Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad 500 078, Telangana, India. 3Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Dr.RafiqZakaria Campus, Aurangabad 431 001, Maharashtra, India.

*Corresponding author: [email protected] Abstract: The monocarbonylcurcumin analogues were modified from curcumin to achieve more stable and active compounds as compared to curcumin. Curcumin is already an active component of turmeric. It was needed to be modified into monocarbonylcurcumin analogues as it shows poor solubility, stability and bioavailability. Therefore, we designed and synthesized a library of eighteen dimeric 1, 2, 3-triazolyl monocarbonylcurcumin analogues (8a-r) and evaluated them for their in vitroantitubercular, antifungal and antioxidant activities against their respective strains. Results of biological activities reveal that most of the compounds of the series show good antitubercular as well as antioxidant activities. The compound 8m was the most active antitubercular agent with MIC 3.125 µg/mL. The other compounds like 8c, 8d, 8e and 8gwere also shows potent antitubercular activity against Mtb H37Rv whereas, the compounds 8e and 8o were shows potent antioxidant activities with IC50 values 15.60 and 15.49 µg/mL, respectively. In support to activities, in silico ADME properties prediction have been also carried out in this study.

Keywords: Dimeric 1, 2, 3-triazoles, Monocarbonylcurcumin analogues, Antitubercular activity, Antioxidant activity, Antifungal activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 100 Exploring New Horizons in Chemical Sciences-2019

PP- 134 Microwave Assisted Synthesis and Screening for Antimicrobial Activity of Some Novel Benzimidazolechalcones

Balasaheb B. Musle 1 Satish V. Gaikwad 2 and Subhash M. Lonkar * Shri Guru Buddhiswami Mahavidhyalaya, Purna (Jn.), Dist: Parbhani.M.S. (India) B.Raghunath Arts, Commerce and Science College, Parbhani.M.S. (India) * P.G. Research Center, Department of Chemistry, Shri Shivaji College, Parbhani.M.S. (India) *Corresponding author: [email protected]

Abstract: A series of benzimidazolechalcones (3a-3i) were synthesized from benzimidazole 2-carbaldehyde and substituted acetophenone by using microwave irradiation. Chalcones had been synthesizing by conventional way of heating which has taking a long time, So as to improve the yield and to minimize the reaction time. Benzimidazolechalcones were elucidated on the basis of spectral analysis such as IR, NMR, and Mass spectroscopy. Synthesized chalcones were shown the highest antibacterial and antifungal activity against all strains with higher values.

Keywords: Benzimidazole-2-carbaldehyde, Substituted acetophenone, MWI, Benzimidazolechalcones, Antimicrobial PP- 135

A novel one-pot three component reaction in ionic liquid: An efficient synthesis of 12-Phenyl-2, 3, 4, 12-tetrahydro-benzo[4,5]thiazolo[2,3-b]quinazolin-1-one aSwapnil R. Sarda, bSunil K. Wasmatkar, bRajendra P. Pawar, cWamanrao N. Jadhav

aDepartment of Chemistry, J. E. S. College, Jalna, India. bDepartment of Chemistry, Deogiri College, Aurangabad, India. cOrganic Chemistry Synthesis Laboratory, Dnyanopasak College, Parbhani, India. *Corresponding author: [email protected]

Abstract: The development of environmentally benign and clean synthetic procedures has become the goal of present day of organic synthesis. Multicomponent reactions (MCRs) are useful in developing different heterocyclic Scaffolds. Due to a wide range of applicability in medicinal, bioorganic, industrial and in the fields of synthetic organic chemistry, there is increasing interest in the development of efficient methodologies for the synthesis of quinazolin-1-one. Herein we report the synthesis of 12-Phenyl-2,3,4,12-tetrahydro-benzo[4,5]thiazolo[2,3-b]quinazolin-1- one promoted by the ionic liquid, ethyl ammonium nitrate [EtNH3]NO3, in excellent yield with shorter reaction time (Scheme-1). A mixture of 1,3-diketone (1 mmol), 2-aminobenzothiazol (1 mmol), aromatic aldehyde (1 mmol) and 2 mL ionic liquid EAN dissolve in acetonitrile, reflux for 3 hours. After completion of the reaction, the reaction mixture was poured onto ice-cold water, filtered, washed with cold water and dried. The ionic liquid can be recycled and reused several times. R

H O O O S EAN NH2 N CH CN, Reflux O N 3 R N S (Scheme-I)

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 101 Exploring New Horizons in Chemical Sciences-2019

PP- 136 DMAP catalysed greener synthesis of pyrano [2, 3-d] pyrimidine diones under ultrasonic irradiation.

Paresh G. Patil and Dhananjay H. More Post Graduate and Research Recognized Department of Chemistry, S.P.D.M. College Shirpur, Dist: - Dhule, (M.S.), India, School of Chemical Sciences, North Maharashtra University Jalgaon, (M.S.), India Paresh G.Patil *Corresponding author:[email protected]

Abstract: DMAP was found to be effective catalyst for the efficent synthesis of pyrano[2,3-d] pyrimidine diones at room tempreture under ultrasonic irradiation. This procedure has many advantages such as excellent yields, simple procedure, short reaction times and milder conditions.

Keywords: Multicomponent reaction, pyrimidine-6-carbonitrile, DMAP, Ultrasonication, Green Chemistry.

PP- 137

An acid catalysed efficient synthesis of dihydropyrimidone derivatives using phosphoric acid Kabeer Shaikh1*Yogesh Salve2Jagdish Musmade3

1P.G. Department of Chemistry, Sir Sayyed College of Arts, Commerce and Science College, Roshangate, Aurangabad,431001, India. 2, 3P.G. Department of Chemistry, Arts, Commerce and Science College Sonai Tal-Newasa, Dist-Ahmednagar, 414105, India.

*Corresponding author:[email protected]

Abstract: The requirement of simple and clean synthesis of heterocyclic compound have been largely increase due to hazardous nature of chemical, so we developed acid catalysed one pot synthesis of dihydropyrimidone derivativesusing aryl aldehyde, keto ester and urea at room temperature results in desired product. Simple and low cost methodology, short reaction time, excellent yield, easy and clean work-up process are important features of the synthesis.

Keywords: Simple and low cost methodology, short reaction time, excellent yield.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 102 Exploring New Horizons in Chemical Sciences-2019

PP-138

Solvent free synthesis and characterization of few metal complexes of Schiff base derived from 2-Amino-5, 6-dimethyl benzimidazole & Syringaldehyde

M. G. Undegaonkar1, V. N. Bhosale2& S. R. Mirgane3

1Dept. of chemistry, ASC College Badnapur, Dist.-Jalna [MS] 2Principal, Shri Shivaji College Kannad, Dist. - Aurangabad [MS] 3Dept. of Chemistry, JES College Jalna, Dist.-Jalna [MS]

*Corresponding author: [email protected] Abstract: A solvent free synthesis of tetra dentate Schiff base ligand was carried out by treating 2-Amino-5, 6- dimethyl benzimidazole & Syringaldehyde in 1:1 molar proportion under scientific microwave oven. Excellent yield was obtained after purification. Few metal complexes of Schiff base were synthesized by using Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ag(I)metal salts in microwave oven under solvent free condition. All metal complexes showed distinct color at the end of reactionand melting point of each complex confirmed the formation of product. A detailed characterization of both Schiff base & its metal complexes carried out by several analytical & spectral techniques.Bioactivity of Schiff base & respective metal complex was studied in various cultures showing significant increase in bioactivity of the metal complex comparing to Schiff base ligand.

Keywords: Solvent free, 2-Amino-5, 6-dimethyl benzimidazole, Syringaldehyde.

PP-139 Microwave assisted synthesis and characterization of some metal complexes of Schiff base ligand derived from 2-Hydrazino benzothiazole & benzil

S.P. Moharir1, S.R. Mirgane2& R.P. Pawar3

1Siddharth ASC College Jafrabad, Dist.-Jalna [MS] 2JES College Jalna, Dist.-Jalna [MS] 3Deogiri College Aurangabad, Dist.-Aurangabad [MS]

*Corresponding author: [email protected]

Abstract: A microwave assisted synthesis of tetra dentate Schiff base ligand was performed by heating 2- Hydrazino-benzothiazole & benzil in 2:1 molar proportion in scientific microwave oven. Yield obtained of product was nearly 90% after purification. Purity of product was confirmed byelemental analysis& spectral analysis i.e. IR, PMR and LC-MS. Some metal complexes of this Schiff base were also synthesized under microwave irradiationby using Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ag(I) metal salts. Each metal complex showed different color asreactions proceed.A thorough characterization of these complexes was also carried out by UV, IR, XRD and TGA/DTA. Antimicrobial activity of both Schiff base &metal complexes studied in various cultures showing markedincrease in bioactivity of the metal complex as compare to Schiff base.

Key Words: 2-Hydrazino benzothiazole, benzil, microwave, XRD, TGA/DTA

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 103 Exploring New Horizons in Chemical Sciences-2019

PP-140

Physicochemical Properties of Metformin HCl in Aqueous Solvent Systems at Different Temperatures S. B. Ingole1, C. D. Thakur2, A. G. Shankarwar3 1, 2, 3Department of Chemistry, S.B.E.S. College of Science, Aurangabad

*Corresponding author: [email protected]

Abstract: The study of the volumetric behavior of Metformin HCl as electrolytes in solution provides information useful to elucidate ion–ion, ion–solvent, and solvent–solvent interactions. Apparent molar volumes (Φv), and excess viscosity for Metformin HCl in aqueous system have been determined from density (ρ) and viscosity (η) measurements at four different temperatures using the ANTON PAAR densitometer and Mansing Survismeter respectively. Various concentrations of aqueous solutions of Metformin HCl ranging from 0.02 to 0.1 M were prepared. The apparent molar volumes were calculated from the density data. In addition adiabatic compressibility and acoustic impedance is also determined. The concentration dependence of the apparent and partial molar volumes can be used to study ion–ion interactions, whereas the partial molar volumes at infinite dilution provide information on ion–solvent interactions.

PP-141

Synthesis, Spectral and Biological Studies of Cu (II), Ni (II), Fe (III), Co (II), Mn(II) and Cd(II) Metal Complexes of DHA Schiff Base Derived From 4- Aminomethyl pyridine D. G. Palke, S. D. Salunke* *Department of Chemistry & Analytical Chemistry, Rajarshi Shahu Mahavidyalaya, Latur, India.

*Corresponding author:[email protected], [email protected]

Abstract The solid metal Complexes of Cu (II), Ni (II), Fe (III), Co (II) Mn (II) and Cd (II) with novel Schiff base ligand. ((E)-1-((pyridin-4-yl)methylimino)ethyl)-4-hydroxy-6-methyl-2H-pyran-2-one derived from DHA (3-acetyl-4-hydroxy-6-methyl-2H-pryan-2-one) and aromatic primary amine, 4- aminomethyl pyridine were synthesized and characterized by elemental analysis , FTIR , UV-VIS and 1HNMR spectroscopic techniques. The signals of 1HNMR spectrum and important bands in IR spectra are considered and discussed in relation to molecular structure of ligand. The UV-VIS absorption bands are assigned to corresponding electronic transitions and are also studied by magnetic study. The biological (Anti-bacterial and Ant-fungal) activity of ligand and metal complexes have been screened in vitro against Bacillus subtilis, Staphylococcus aureus, Aspergilus niger and Candida albicans. Schiff base ligand as well as all metal complexes have shown harmonious biologically activities.

OH OH O N-R + H2O + H2N-R O O O O DHA DHA Schiff Base

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 104 Exploring New Horizons in Chemical Sciences-2019

PP-142 Synthesis, Characterization and Biological Screening of Some Novel Halogenated Flavones V. R. Phatake1, M. S. Jangale1 and B. R. Madje2

1Department of Chemistry, Arts, Commerce & Science College Sonai,Tal- Newasa,Dist,Ahmednagar,414105,India 2Department of Chemistry, V. N. College, Aurangabad *Corresponding author: [email protected] Abstract: The flavones are a class of naturally occurring compounds that are widely distributed in vascular plants and posses biological activities such as anticancer, antibacterial and antifungal etc. Chalcones on reaction with catalytic amount of I2 in DMSO gives flavones. In present work we have synthesize some halogenated 2-pyrazoyl Chalcones by Clasien-Schmidt condensation. This Chalcones the react with catalytic amount I2 in DMSO gives flavones in good yield. Then obtained halogenated flavones are studied for antifungal and antibacterial biological activity.

Keywords: Chalcones, Flavones, Claisen-Schmidt condensation, Biological activity

PP-143

Synthesis and characterization of cobalt oxide nanomaterial in CTAB as a surfactant using eco-friendly sol-gel method in aqueous medium.

J. S. Godse1, S. B. Gaikwad2, V. B. Bhise3, R.P.Pawar2, S. B. Ubale1* 1Department of chemistry, Deogiri College, Aurangabad (MS), India. 2Department of Chemistry, L P G Arts and Science College, Shirpur (Jain), Washim (MS), India. 3Department of Physics, L P G Arts and Science College, Shirpur (Jain), Washim (MS), India.

*Corresponding author: [email protected] Abstract: A new green synthetic approach of cobalt oxide (Co3O4) nanomaterial in CTAB using sol-gel method was investigated.Investigation of nanomaterial was done by X-ray diffraction (XRD), Transmission electron microscopy (TEM), Energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR) and UV–Visible spectroscopy. Highly dispersed characterization results were shown by the synthesized nanomaterial. This green approach proves an effective, eco-friendly, simple and valuable approach for the synthesis of Co3O4 nanomaterial.

Keywords: Nano cobalt oxide, Green synthetic approach, Nanomaterial.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 105 Exploring New Horizons in Chemical Sciences-2019

PP- 144

Nanoparticle Catalysis in Organic Synthesis: Milestones and Challenges

Mujahid Kazafi1, Javed Shaikh2, K. M. Doke2, Yusufi Mujahid2*

1) Department of Chemistry, MGV’s Arts, Commerce and Science College, Malegaon City- 423203(Affiliated to SPPU, Pune) 2)Post Graduate Department of Chemistry, Abeda Inamdar Senior College of Arts, Science and Commerce, Pune-411001 (Affiliated to SPPU, Pune)

*Corresponding author: [email protected]

Abstract: In the present times, catalytic role of Nano-particles (NPs) has gain significant focus. Green Chemistry methods for the syntheses of NPs and their use as catalysts in organic reactions have been on the rise. There has been a remarkable development in this particular area and a review on this subject is relevant for researchers interested in the field of Green Chemistry and NPs catalyzed organic synthesis. The present review covers catalytic role played by nanoparticles in many organic reactions.

Keywords: Nanoparticles, Coupling reactions, Green chemistry

PP- 145

Kinetic Study of the reaction of Schiff base with Thioglycolic acid Spectrophotomerically

Bhausaheb K. Magar Department of Chemistry, Shivaji Arts Commerce and Science College Kannad, Dist.Aurangabad, Maharashtra, India.

*Corresponding author:[email protected]

Abstract: The second order reaction rate constant for the reaction of Schiff base with thioglycolic acid have been reported in ethanol at temperature range 303 to 318 k .The rate of reaction is first order with respect to Schiff base and thioglycolic acid. The rate of reaction increases with increases in temperature. The thermodynamic parameters are used to explain the nature of reaction. Suitable reaction mechanism has been suggested for the formation of 4-thiazolidinone. From the effect of temperature on the rate of reaction various thermodynamic parameter have been evaluated.

Keywords: Schiff base, Thioglycolic acid, 4-Thiazolidinone, Kinetics.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 106 Exploring New Horizons in Chemical Sciences-2019

PP-146 Synthesis of Novel Spiro[ Chroman-2,4-piperidin]-4-one Derivatives and its Biological Study.

Abhay S. Bondgeⱡ¥, Kalimoddin I. Momin‡ⱡ, Vikas B. Suryawanshiⱡ, Jairaj K. Dawleⱡ*

ⱡResearch Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH- 413521. ¥ Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra- -413544. ‡Rajarshi Shahu College, Latur, Maharashtra-413512

*Corresponding author: [email protected]

Abstarct: we have synthesized novel spirochromone derivatives with moderate to good yield. The starting material is commercially available and it is cheap. We have screen these compounds for biological activity, the compounds S-6,S-9,B-6, shown good antimicrobial activity against C.albicans, C.neoformans cells. By using this protocol library of compounds can be synthsized and their biological activity can be study.

PP-147 A novel highly efficient Taurine catalyzed environmentally-compatible Approach for the synthesis of Multicomponent tandem reaction of valuable novel benzylpyrazolyl coumarin in water in-water: Green chemical methodologies in organic synthesis

Chetan K. Jadhav, Amol S. Nipate, Asha V. Chate, Charansingh H. Gill* Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, M.S., India. *Corresponding author: [email protected]

Abstract: Green chemistry is likely to be ideal partners for accessing novel chemical spaces and define highly efficient synthetic tools. A highly efficient domino protocol for synthesis of pharmaceutically interesting diverse kind of a new series of functionalized 2-benzoyl-4-((4-hydroxy-2-oxo-2H-chromen- 3-yl)(phenyl)methyl)-5-methyl-1H-pyrazol-3(2H)-one derivatives 5 (a-k) has been developed using Taurine as a bio-organic natural catalyst in a green reaction medium at 70 οC temperature with a very short reaction time 35-45 min. The salient features of this protocol performing the MCRs in a green approach based on recoverability, recyclability and avoidance of waste, efficient and highly economical procedure, no need of column chromatographic purification with high atom economy, eco-friendliness and, therefore, such features make processes in flow highly interesting in terms of developing a green and sustainable chemistry.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 107 Exploring New Horizons in Chemical Sciences-2019

PP- 148 Anti-proliferative activity and Kinase inhibition studies 2-(2-(trifluoromethyl)- 6-(3-fluorophenyl) imidazo [1, 2-a] pyrimidin-3-yl)-N-substituted cetamide derivatives Chandrakant D. Pawara*, Sadhana L. Chavana, Umakant D. Pawarb, Dattatraya N. Pansarea, Santosh L. Chavanc, Rajendra P. Paward, Devanand B. Shindee aDepartment of Chemical Technology, Dr. Babasahaeb Ambedkar Marathwada University, Aurangabad, 431004 (MS), India bRegional Forensic Science Laboratories, Aurangabad, 431004(MS), India cMaharashtra Pollution Control Board, Aurangabad, 431004(MS), India dDepartment of Chemistry, Deogiri College, Aurangabad, 431005 (MS), India eShivaji University,Vidyanagar, Kolhapur- 416 004(MS), India *Corresponding author: [email protected]

Abstract: A series of novel imidazo [1, 2-a] pyrimidin-3-yl)-N-substituted amide derivatives were synthesized from a 2, 5-dichloropyrimidine. A simple strategy was developed for the synthesis of imidazole and pyrimidine derivatives in fused ring were reported via a series of steps. The structure of the synthesize compounds were confirmed by IR, 1H NMR, 13C NMR,19F NMR, mass spectra, elemental analysis and purity is checked by HPLC. All synthesized compounds were screened for anticancer activity against A- 549 and MCF-7 cancer cell lines by MTT assay. The preliminary bioassay suggests that most of the compounds show anti-proliferation with different degrees, doxorubicin was used as positive control. The synthesized compound shows IC50 values in the range of 1.44-16.17 µM in both cell lines. Most of the derivatives were active for MCF-7 cancerous cell line as compared with standard. PP-149

Synthesis, anti-proliferative activity studies of 2-(2-(trifluoromethyl)-6- (substituted)imidazo[1,2-b]pyridazin-3-yl)-N-(substituted)acetamide derivatives Chandrakant D. Pawara*, Sadhana L. Chavana, Umakant D. Pawarb, Dattatraya N. Pansared, Santosh L. Chavanc, Rajendra P. Paward, Devanand B. Shindee aDepartment of Chemical Technology, Dr. Babasahaeb Ambedkar Marathwada University, Aurangabad, 431004 (MS), India bRegional Forensic Science Laboratories, Aurangabad, 431004(MS), India cMaharashtra Pollution Control Board, Aurangabad, 431004(MS), India dDepartment of Chemistry, Deogiri College, Aurangabad, 431005 (MS), India eShivaji University,Vidyanagar, Kolhapur- 416 004(MS), India.

*Corresponding author:[email protected] Abstract A series of novel imidazo [1,2-b]pyridazin-3-yl acetamide derivatives were synthesized from a 3,6- dichloropyridazine. We have developed a simple strategy for the synthesis of functionally diverse imidazole and pyridiazine derivatives were reported via a series of steps. The work involves bicyclic imidazo-pyridazine ring formation, halogenation, cynation, hydrolysis, peptide coupling and Buchwald reaction. The structure of the synthesize compounds were confirmed by IR, 1H NMR, 13C NMR,19F NMR, mass spectra, elemental analysis and purity is checked by HPLC. All synthesized compounds were screened for anticancer activity against A-549 and Du-145 cancer cell lines by MTT assay. The preliminary bioassay suggests that most of the compounds show anti-proliferation with different degrees, doxorubicin was used as positive control. The synthesized compound shows IC50 values in the range of 1.74-16.17 µM in both cell lines. The compounds 9e, 9g and 9h were active compared with doxorubicin in both the cell lines. The compounds having cyclopentyl ring are active compared with higher and lower carbon analogues.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 108 Exploring New Horizons in Chemical Sciences-2019

PP- 150 Application of Organic clays for Biginelli reaction by microwave as greener method. V. M . Kamble *, Supriya P. Babar Department of Chemistry, The Institute of Science, 15, Madam Cama Road, Mumbai-32.

*Corresponding author: [email protected]

Abstract: Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4- dihydropyrimidin-2 (1H) –one derivatives. This synthesis was performed in the presence of Red, White and Black clay as a catalyst. These reactions were performed under solvent-free conditions with microwave irradiation as the energy source. This new method has the advantage of excellent yields (90- 95%). The advantages of this novel protocol include the excellent yield, operational simplicity, short time, and the avoidance of the use of organic solvents and eco-friendly preparations.

Keywords: 3, 4- dihydropyrimidin-2 (1H) -ones, Solvent-free, Microwave irradiation, red, white and black clay PP-151 Synthesis of N-(6, 7-dihydro-7-oxo-5-substituted-thiazolo [5, 4-d] pyrimidin-2- yl)-4-substitued amide derivatives showing anti-proliferative activity

Dattatraya D. Gaikwada , Chandrakant D. Pawarb*, Sadhana L. Chavana, Umakant D. Pawarc, Dattatraya N. Pansarea, Santosh L. Chavand, Rajendra P. Pawara, Ashok M. Zinea

aDepartment of Chemistry, Deogiri College, Aurangabad, 431005 (MS), India bDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004 (MS), India cRegional Forensic Science Laboratories, Aurangabad, 431004(MS), India dMaharashtra Pollution Control Board, Aurangabad, 431004(MS), India

*Corresponding author:[email protected] Abstract: A series of novel substituted-thiazolo [5, 4-d] pyrimidin-2-yl amide derivatives were synthesized starting from thiourea and (E)-3-chloro-3-nitroacrylonitrile. Total 12 analogous were synthesized by using cyclization, reduction, displacement and coupling reactions. For displacement and cyclization we have used lewis acid as catalyst to get good yields. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, 19F NMR, LCMS, elemental analysis and purity is confirmed by HPLC. All synthesized compounds were screened for anticancer activity against HeLa, A-549 and Du-145 cancer cell lines by MTT assay. The preliminary bioassay suggests that most of the compounds show anti- proliferation with different degrees; doxorubicin was used as positive control. The synthesized compound shows IC50 values in the range of 1.24-8.17 µM in different cell lines. The compounds were active than standard doxorubicin. The compounds having electron withdrawing substituents were most active compared with electron donating groups. Keywords: Thiazole, Pyrimidine, Amide, Cyclization, Anticancer

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 109 Exploring New Horizons in Chemical Sciences-2019

PP-152 High Performance Thin Layer Chromatographic Detection of Organophosphorous Herbicide Glyphosate in visceral samples

Umakant D. Pawar1, Chandrakant D. Pawar2. Rajendra K. Pardeshi3* 1Department of Chemistry Dr Rafiq Zakaria College for woman Navkhanda Aurangabad. MS, India. 2Department Chemical Technology Dr. Babasahab Ambadker Marathwada University Aurangabad .MS, India. 3Department of Chemistry Sant Ramdas College Ghansawangi, Jalna, MS, India. *Corresponding author:[email protected] Abstract: The agricultural use of organophosphorus herbicides was used to kill weeds, especially annual broadleaf weeds and grasses that compete with crops have increased vastly in recent years. In India the ready availability of these herbicides has leads to a highlyexpand the ratio in human poisoning cases. The herbicide Glyphosate (N-(phosphonomethyl)glycine or 2-[(hydroxy- oxidophosphoryl)methylamino]acetic acid), is often misused for homicidal or suicidal and accidental poisioning cases. During 2015 the Forensic Science Laboratories of Maharashtra state detected approximately 100 cases of human poisoning by glyphosate. Because of the large number of visceral samplesreceived for detection of poison, high performance thin-layer chromatography (HPTLC) is the method of choice because of its speed, low cost and versatility.

Key Words: High Performance Thin-layer chromatography, Organophosphorousherbicide, Glyphosate, Visceral Samples. PP-153

Synthesis and antimicrobial screening of 5-(substituted phenyl)-N-(2-oxo-2- substituted-phenylethyl)-N-methylfuran-2-sulfonamide derivatives

Santosh V. Deshmukha , Chandrakant D. Pawarb*, Sadhana L. Chavanc, Umakant D. Paward, Dattatraya N. Pansareb, Rajendra P. Pawarc, Milind B. Ubalea

aDepartment of Chemistry, Vasantrao Naik college, Aurangabad, 431004(MS), India bDepartment of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004 (MS), India cDeogiri College, Aurangabad, 431004(MS), India dRegional Forensic Science Laboratories, Aurangabad, 431004(MS), India.

*Corresponding author:[email protected]

Abstract: At present work we synthesized substituted furan sulfonamides compounds. We have developed reaction conditions for series of 5-(substituted phenyl)-N-(2-oxo-2-substituted-phenylethyl)-N- methylfuran-2-sulfonamide derivatives (4a-4m). We have optimized methodology for targets from milligram scale to multi gram scale. The structure of synthesized compounds was elucidated and confirmed by 1H NMR, 13C NMR, LCMS and purity was checked by HPLC. All the synthesized final compounds (4a-4m) are screened for antimicrobial activity (minimum inhibitory concentration) against a series of strains of Bacillus subtillis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus niger for antifungal activity. The results of antimicrobial screening data revealed most of compounds (4a-4m) showed moderate to promising microbial inhibitions.

Keywords: Furan, Sulfonamide, Suzuki, Antimicrobial activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 110 Exploring New Horizons in Chemical Sciences-2019

PP-154 β-CD Catalyzed Facile and Efficient Synthesis of Pyrido[2,3-d:6,5- d']dipyrimidin-4-methylbenzenesulfonamide viaMulticomponent Approach Satish V. Akolkar and Bapurao B. Shingate* Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, Maharashtra (India)

*Corresponding author: [email protected]

Abstract: Pyridopyrimidines and their derivatives areimportant heterocyclicmoiety that is the essential family of naturalproducts and drug molecules with remarkable structural featuresand a wide range of useful pharmacological and biological properties.1 Moreover, some of pyridopyrimidines also displays important biological activities such as; tyrosine kinase inhibitors,2antitumor3etc.Considering the significance of pyridopyrimidines here, we have developed a simple and efficient protocol for the synthesis of pyridopyrimidines derivatives via multicomponent reaction of aromatic aldehyde, barbituric acid and 4-methylbenzenesulfonohydrazide in presence of of β-Cyclodextrin (β-CD) as catalyst in water.Developed method has important advantages, such as simple and green method, easy workup and safer alternative to hazardous and corrosive solvents.

PP- 155

Synthesis of Diketopyrrolopyrrole (DPP) using ionic liquid as a co-solvent

Virbhadra G. Kalalawe & Dashrath R. Munde Department of Chemistry, N.E.S.Science College, Nanded.Maharashtra. *Corresponding author: [email protected]

Abstract: Diketopyrrolopyrrole (DPP) as an important monomer, precursor for many synthesis conjugated polymers and organic pigments. Herein, we modify the synthesis DPP preparation method, using ionic liquid as a co-solvent. In this study, Furan DPP, Thiophene DPP and Pyridine DPP are synthesized at 70oC with increase in the yield reported by previous method. These DPPs are characterized by 1H NMR and 13C NMR. The optical properties are recorded and textures of DPP films are also analyzed. DPPs are structurally based on 2, 5-dihydropyrrolo [4, 3- c] pyrrolo-1,4-dione as shown in the following figure 2 Ar H 1 N 3 O 6a 3a O 4 6 N5 H Ar

DPPs have been rapidly adopted for numerous industrial applications such as pigments in paints, varnishes, and high quality printing ink. The DPP has attracted considerable research interest over the last few years. DPP has a planar structure and can induce strong intermolecular H-bonding and p–p stacking with neighboring molecules. Present work illustrated in the following scheme.

CN Ar H O Ionic liquid N O OEt Ar + EtO Solvent O O N H Ar

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 111 Exploring New Horizons in Chemical Sciences-2019

PP-156 Green synthesis of 4-methoxybenzylidene thiazole derivatives catalyzed by potassium carbonate under ultrasound irradiation

Dattatraya N. Pansare,a* Rohini N. Shelke,a Rajiv A. Jadhav,a Saroj R. Bembalkar a aDepartment of Chemistry, Deogiri college, Station road, Aurangabad 431 005, MS, India.

*Corresponding author: [email protected]

Abstract: An environmentally benign aqueous protocol for the synthesis of novel 2-((5-(4-methoxybenzylidene)- 4-oxo-4,5-dihydrothiazol-2-yl)amino)substituted acid by using potassium carbonate as a catalyst has been achieved. These ultrasound irradiation and conventional technique reaction proceed efficiently in water in the absence of organic solvent. In comparison with conventional methods, our protocol is convenient and offers several advantages, such as shorter reaction time, higher yields, milder conditions and environmental friendliness.

Keywords: 4-Methoxybenzylidene; Water; Ultrasonic irradiation; Potassium carbonate.

PP- 157 A Robust Synthesis of 4-substituted 1,5- BenzodiazepinesUtilising Silica Supported-TBAF as a Recyclable Catalyst in Solvent-free Conditions

Pranav K. Pawarb,Yogesh R. Deokarc, Vijay P. Pagorea, Shivaji B. Mundea, Vivekanand B. Jadhav*a aDepartment of Chemistry, Shri Muktanand College, Gangapur, Tq.-Gangapur, Dist.-Aurangabad, Maharashtra, India.Pin-431109. bDepartment of Chemistry, Arts, Science & Commerce College, Rahuri, Tq.-Rahuri, Dist.-Ahmednagar, Maharashtra, India.Pin-413705. cDepartment of Chemistry, Sanjivani College, Vaijapur, Tq.-Vaijapur, Dist.-Aurangabad, Maharashtra, India.Pin- 423701. *Corresponding author:[email protected] Abstract: Benzodiazepines have gathered name and fame in the market as they are one of the major constituents of drugs that are utilized for psychotropic, Anti-anxiety, Schizophrenia, Platelet-activating factor inhibitor and as Muscarinic receptor-M1 antagonist drugs. Benzodiazepine and their derivatives are one of the highly sold psychoactive drugs across the globe. In addition to this 1,5-benzodiazepines based fused ring system containing heterocyclic compounds has widened their medicinal utility as anantidepressant, anti-inflammatory, hypnotic, anticoagulant, antibacterial,analgesic and antiepileptic agents. All these pharmaceutical importance has the triggered notable attention from the researchers worldwide &thus we thought of developing a facile route that can push back all these drawbacks and also meet with theconcept of green chemistry also. Hence we have utilized a recyclable Silica supported-TBAF, as a novel catalyst for the three component reaction of dimedone, 1, 2-diamine and Aromatic Aldehyde in solvent-free conditions at 1000C giving the product in anexcellent amount of yield within 30 minutes of reaction time. Thus we have introduced an efficient, clean, solvent-free reaction protocol that uses a cheaper, environmentally benign, recyclable catalyst that can deliver the product with theexcellent amount of yield in shorter reaction time.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 112 Exploring New Horizons in Chemical Sciences-2019

PP- 158

Waste Plastic to Useful Fuel: A Review Bhawna N. Visputea, R. P.Pawarb*, Dr. S. N. Patelc* aNMU,Jalgaon, b*-Deogiri college Aurangabad,c*-S.P.D.M.college Shirpur. *Corresponding author: [email protected]

Abstract: Increasing plastic waste is a serious issue facing all over the world. Its non-bio degradability makes it harmful for all living things. Simultaneously, world facing shortage of energy source materials which are non renewable .This review focused synthesis of energy source material by degradation of plastic waste. Keywords: Energy source, polymerization, pyrolysis, degradation, Thermosets, thermoplastic, hydrocarbons etc.

PP- 159

Synthesis of Pharmaceutically Valued Coumarin Based Pyrazolone Conjugates Yogesh R.Deokara, Pranav K. Pawarb, Vijay P. Pagorec, Vivekanand B. Jadhav*c

aDepartment of Chemistry, Sanjivani College, Vaijapur, Tq.-Vaijapur, Dist.-Aurangabad, Maharashtra, India.Pin-423701. bDepartment of Chemistry, Arts, Science & Commerce College, Rahuri, Tq.-Rahuri, Dist.-Ahmednagar, Maharashtra, India.Pin-413705. cDepartment of Chemistry, ShriMuktanand College, Gangapur, Tq.-Gangapur, Dist.-Aurangabad, Maharashtra, India.Pin-431109.

*Corresponding author: [email protected] Abstract: It is well awared across the globe within scientific community that majority of Coumarin and their derivatives possess a remarkably biological activities ranging from antibacterial, antifungal , anti- inflammatory, anticoagulant, antitumour, antioxidant and anti-HIV. Among the various Coumarin derivatives, basically hydroxyl derivatives, 4- and 7- hydroxycoumarins, are biologically most potent and very important for the synthesis of other coumarin based conjugates derivatives. This may lead an enahanced activity or may drag down the biological potential of synthesized scaffolds. So an attempt is made to synthesize Coumarin based Pyrazolone derivatives and it’s possible screening for it’santituberculosis and antimicrobial activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 113 Exploring New Horizons in Chemical Sciences-2019

PP- 160

A clean and highly efficient synthesis of 4,4’-(phenylmethylene)bis(3-methyl-

1H-pyrazol-5-ols) using Mg(SO4).7H2O as homogeneous catalyst

Arvind K. Aghao1*, S. B. Jadhav1, D. P. Gholap2 1Department of Chemistry, Balbhim College, Beed - 431 122 (M.S.) India. 2Department of Chemistry, Smt.C.H.M. College, Ulhasnagar, Dist.Thane-421003(M.S.) India.

*Corresponding author: [email protected]

Abstract: The synthesis of 4,4’-(phenylmethylene)bis(3-methyl-1H-pyrazol-5-ols) was performed effectively by the reaction of aryl aldehydes and 3-methyl-1H-pyrazol-5(4H)-one in the presence of a catalytic amount of Mg(SO4).7H2O as environmentally friendly catalyst in DMF-Methanol (1:1) solution on stirring for 30 min in 80-98% yields. All of the obtained compounds were characterized by ethanol and characterized by IR, H1NMR, Elemental analysis, 13C NMR. The method has the advantages of high yields, short reaction time, and simple work-up. Keywords: 4, 4’-(Phenylmethylene)bis(3-methyl-1H-pyrazol-5-ol), 3-methyl-1H-pyrazol-5(4H)-one,

Mg(SO4).7H2O,Green approach, Multi component reaction. PP- 161

Synthesis, Characterization and Biological Activity of Transition Metal Complexes of Schiff Base Ligand containing 1, 3, 4 Thiadiazole Moiety.

Ajay M Patil*a, Chandrashekhar G.Devkateb, Rajendra P Pawarc, Sunil R Mirganed

*aDepartment of Chemistry, Pratishthan College Paithan, Aurangabad-431107 India bDepartment of Chemistry, Indraraj Arts, Commerce, Science, College, Sillod, Aurangabad-431112 India. cDepartment of Chemistry Deogiri College,Aurangabad-431001 dDepartment of Chemistry, J.E S College,Jalna-431203 *Corresponding author:[email protected]

Abstract: New 1,3,4 Thiadiazole moieties containing Ligand and their metal complex of Fe(III), Co(II), Ni(II) was prepared by using 5-amino-1,3,4-thiadiazole-2-thiol and substituted Salicyladehyde derivatives. The ligand and its metal complexes were analyzed and characterized by different spectroscopic techniques (UV, FT-IR, 1HNMR, 13CNMR, HRMS), Magnetic Susceptibility and molar conductance, elemental analysis. The transition metal complexes show moderate to excellent antifungal activity against Aspergillus Niger and Fusarium Oxysporum and antibacterial activity against Staphylococcus aureus and Bacillus subtilis using Kirby-Bauer disc diffusion method. The synthesis of new potential metal derived drug.

Keywords: Salicyladehyde, Thiadiazole, Schiff Base, Metal complexes, Antimicrobial activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 114 Exploring New Horizons in Chemical Sciences-2019

PP- 162 Synthesis and Antimicrobial Activities of some Schiff base and their metal complexes.

R.U. Ambhure,1 D.U.Thombal 2.S. R. Mirgane3 Dept of Applied Science I.O.K.College of Engineering, Pimple Jagtap, Tal Shirur Dist Pune (M.S.), 41208. Dept of Chemistry L.B.S. College Partur Dist Jalna (M.S.) 431501 P.G. Dept of Chemistry J.E.S. College Jalna Dist Jalna (M.S.) 431203

*Corresponding author: [email protected], [email protected] Abstract: Schiff base and their metal complexes were synthesized. All synthesized Schiff base and their metal complexes were characterized and screened for antimicrobial activity.

Key words: Synthesis, activities, Schiff base, Metal Complexes

PP-163

Microwave assisted Ionic liquid catalyzed one-pot synthesis of hexahydroquinoline derivatives

Amol V. Sapkal, Balaji R. Madje* Department of chemistry, Vasantrao Naik Mahavidyalaya, Aurangabad, (MS)- 431003, India. *Corresponding author: [email protected] Abstract: Ionic liquid catalyzed one-pot synthesis of hexahydroquinoline derivatives using dimedone, ammonium acetate, aryl aldehydes and malononitrile has been described under microwave irradiation. The protocol utilizes mild reaction conditions excellent yield, shorter reaction time, and a simple workup procedure. The synthesized derivatives were obtained in 90-95% yields and were characterized by IR, 1H NMR, and Mass spectra.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 115 Exploring New Horizons in Chemical Sciences-2019

PP-164

Design and Synthesis of Diketopyrrolopyrrole (DPP) based conjugated organogels M. V. Kanetkar1, S.S. Dharmapurikar2, V. G. Kalalawe1, J. M. kondre1 and G. K. Kakade3

1Yogeshwari Mahavidyalaya Ambajogai. 2N. E. S. Science College Nanded. 3Arts, Science and commerce college Kille-Dharur.

*Corresponding author: [email protected] Abstract: The supramolecular self-assembly of π-conjugated materials and organic dyes is a very attractive approach towards synthesis of novel organogelators. In fact, through a rational chemical design and careful selection of the building block, it is possible to control the molecular self-organization process and packing arrangement, which define important properties such as charge transport, absorbance/fluorescence, stretchability, etc. Herein, we synthesized hydrogen bonded urethane side chain substituted Diketopyrrolopyrrole (DPPurethane) organogelators. Further we investigated compatibility of DPP toward formation of organogels by substituting different side chains i.e. DPPurea and DPP alkyl. Further, we manipulate the structure of DPP such conjugated back-bone and position of hydrogen bonding to study the supramolecular organization and consequently their gelation properties. The gelation properties are studied using NMR, UV-Vis absorbance spectra and SEM microscopy.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 116 Exploring New Horizons in Chemical Sciences-2019

PP-165

Physico thermal and biological studies of some Transition metal ion chelae of 2-(4, 5dhydro-1H-Pyrazol-5-yl) phenol

S. B. Garud, S. D. Ballal

1. Department of Chemistry, Vasantrao Naik Collage. Nanded. Maharashtra, India. 2. Department of Chemistry, Sharda Mahavidalaya, Parbhani, Maharashtra, India.

*Corresponding author: [email protected]

Abstract: The solid metal ion Chelates of Cu (II), Ag(II), with 2-(4.5dihydro-1H-pyrazol-5-yi) phenol were synthesized and characterized by physicochemical, biological, spectral analysis. This research paper includes thermo gravimetric study and antimicrobial activities were studied. The thermal decomposition of the entire metal ion Cheats were studied by the Thermogravimetry (TG) method and the differential thermal analysis (DTA). The synthesized ligand and its metal ion Chelates were screened for their antibacterial activity against three Gram-negative disease causing pathogenic bacteria (Escherichia coli, Shigella sp. and Salmonella typhimurium) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains using agar-well diffusion method using Chloramphenicol as control standard and for in antifungal activity agar diffusion method against the fungi Aspergillus niger, Pencillum notatum, Fusarium oxysporium and Rhizoctoniasolani using Nystatin as standard. The results of these studies showed the metal ion chelate to be more antibacterial/antifungal against one or more species as compared with the chelating agent. Keywords: 2-(4.5-Dihydro-1H-pyrazol-5-yi) phenol; biological study; Transition metal ion chelate. PP- 166 Synthesis and antibacterial activities of α-hydroxyphosphonates by highly efficient one pot synthesis of novel quinoline-phosphonate derivatives catalyzed by eco-benign catalyst alum.

V. A. Tidke 1*, R. U. Pokalwar 2 Vai. Dunda Maharaj Degloorkar Mahavidhyalay, Degloor, Dist- Nanded, MS, India.

*Corresponding author: [email protected]

Abstract: Highly efficient route for one pot synthesis of novel quinoline-phosphonate derivatives has prepared by treating 2-chloroquinoline-3-carbaldehyde and diethyl phosphate by modified Abramov reaction using chloro [trimethyl] silane [TMSCl] in the presence of alum as a catalyst at room temperature. Compare to other methods, the present scheme is a green protocol as it eliminate the need for toxic volatile organic solvent and additional catalyst and other advantages such as shorter reaction duration, high yield of product, simple operating procedure, mild reaction condition. The synthesized α- hydroxyphosphonates compounds were screened for antibacterial activities. The compound showed comparative activity against their standard streptomycin.

Keyword: Quinoline-phosphonate, 2-chloroquinoline-3-carbaldehyde, Abramov reaction, alum, α- hydroxyphosphonates, TMSCl, streptomycin.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 117 Exploring New Horizons in Chemical Sciences-2019

PP-167 A Green Synthesis of Isoquinolines Using Ru(II)/PEG-400 as Homogeneous Recyclable Catalyst via C-H/N-N bond Activation Shrinivas L. Nakkalwar, Hanmant M. Kasralikar, Nitish S. Kaminwar, Shivaji B. Patwari and Vivekanand B. Jadhav* aDepartment of Chemistry, L. B. S. Mahavidyalaya, Dharmabad, Dist. Nanded, MS, India. bDepartment of Chemistry, Shri Muktanand Mahavidyalaya, Gangapur,Dist. Aurangabad MS, India. *Corresponding author: [email protected] Abstract: Isoquinoline ring has been found to possess wide range of biological and pharmacological applications such as antimalarial, anti-HIV, insect growth retarding antitumor, antimicrobial, antileukmic antibacterial and Parkinson's disease activity. In addition to this, isoquinoline represents one of important structural scaffold found in various natural products and pharmaceutical compounds. To investigate this chemical space several protocols have been developed for the synthesis of isoquinoline ring. In present work, a novel and green synthesis of 1-Phenyl Isoquinoline derivatives have been developed by using Ru(II)/PEG-400 as homogeneous recyclable catalyst via C-H/N-N bond activation via C-H/N- N functionalization of 1-(diphenylmethylene) hydrazine and Aryl substituted acetylenes. In order to make the proposed protocol Cu(OAc)2 and AgSbF6 are used as an oxidant and additive respectively in PEG-400 biodegradable solvent. This protocol gives a simple extraction procedure, biodegradable solvent, high atom economy, reusable catalytic system, wide substrate scope with high yield of product for the synthesis of isoquinoline derivatives.

H N 2 N

i + R 1 R2 N

R1 R2 1 2(a-n) 3(a-n)

PP-168

Facile synthesis of 3, 4-dihydropyrimidin-2(1H)-ones using Yttrium oxide catalyst Suresh U. Shisodia[a]*, Sudam S. Pandule[a], Pooja U. Pawar[a], Rajendra P. Pawar[a] [a]Department of Chemistry,Deogiri College, Station Road, Aurangabad-431 005, MS, India.

*Corresponding author:[email protected] Abstract: An efficient synthesis of known biologically active3, 4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, β-ketoester and urea is reported by using heterogeneous Yttrium oxide as a recyclable catalyst. The advantages of this method are mild reaction conditions, low loading of catalyst, short reaction time and excellent yields with high purity. Yttrium oxide is heterogeneous, recyclable, mild and cheap catalyst. The catalyst can be used several times without loss of much activity. Factors affecting on yield of the reaction such as temperature, amount and recyclability of catalyst are also studied.

Keywords: Multi-component reaction, Yttrium Oxide (Y2O3), Catalysis, 3, 4- dihydropyridiumidin- 2(1H)-one.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 118 Exploring New Horizons in Chemical Sciences-2019

PP-169 L-Proline Based Chiral Bifunctional Thiourea-Organocatalyst For Efficient Asymmetric Michael Addition of Cyclic Ketones to β-nitrostyrenes. Hanmant M.Kasralikara, Shrinivas L. Nakkalwarb, Shivaji.B. Patwaric and Sudhakar R. Bhusarea* a,b,cDepartment of Chemistry, L.B.S. College, Dharmabad-431809, MS, India a*Department of Chemistry, Dnyanopasak College, Parbhani-431 401, MS, India *Corresponding author: [email protected]

Abstract: Novel two L-Proline analogues of organocatalysts were synthesised, first is the assembly of a structurally well-defined cyclohexane scaffold with thiourea moieties and amine functionalities could constitute a new class of organocatalysts. Second is the triazole-3-thione analogue. The first one found to be efficient catalysts for the direct Michael addition between ketones and β-nitrostyrenes. The catalysts exhibited high catalytic activity, diastereoselectivity and excellent enantioselectivity at room temperature with a low loading.

O S N NH N N N N H H H N H S Catalyst 1 Catalyst 2 O O NO NO 2 * * 2 + i n R 1 2 3

PP- 170

One-Pot Facile Synthesis of New 1, 2, 3-Triazole-Appended α-Aminophosphonates Ashruba B. Danne and Bapurao B. Shingate* Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, Maharashtra (India) *Corresponding author: [email protected] Abstract: Organophosphorous compounds have found a wide range of applications in the agriculture, organic and medicinal chemistry owing to their biological and pharmacological properties as well as synthetic intermediates. The α-aminophosphonates is well-known privileged structure and have wide range of applications in medicinal chemistry and are structural analogues of amino acids.2 The α- aminophosphonates possesses a wide spectrum of biological activities including antifungal, antimicrobial, antiviral, anticancer and anti-inflammatory activities. The 1,2,3-triazole are well known pharmacophoric scaffolds in medicinal chemistry.3 Herein, we would like to present the new α- aminophosphonates bearing 1,2,3-triazolyl moiety were easily synthesized by one-pot reaction of 1- aryl-1H-1,2,3-triazole-4-carbaldehydes, anilines and trimethyl phosphite in good to excellent yields. The synthesised compounds were characterised by spectral analysis. These new 1, 2, 3-triazole- appended α-aminophosphonates may be potential biological compounds due to the presence of both important moieties like 1, 2, 3-triazole and aminophosphonates.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 119 Exploring New Horizons in Chemical Sciences-2019

PP-171

Monosodium Glutamate: An efficient and green catalyst for the synthesis of bis(pyrazol-5-ol)s under solvent free condition

aManoj P Palve*, aJaysing M Dinore, bRajendra P Pawar, cRajita D Ingle aDepartment of Chemistry, Indraraj Arts, Commerce and Science College, Sillod. bDepartment of Chemistry, Deogiri College, Aurangabad. cR. B. Attal College of Arts, Science and Commerce, Georai, Beed.

*Corresponding author: [email protected]

Abstract: In this work, a simple and efficient method for the synthesis of highly functionalized bis (pyrazol-5-ol)s derivatives has been developed by using Monosodium Glutamate as a catalyst under solvent free condition. Due to significant reduction in cost and eco-efficient MSG as most abundance in nature and safe for consumption it may be considered as an attractive approach for the synthesis of Bis (pyrazol-5- ol)s.Synthesized compoundswere characterized byspectral techniques FT-IR, 1H-NMR and 13C-NMR . The present synthetic route is a green protocol offering several advantages, such as high yield of products, shorter reaction time, mild reaction conditions, minimizing chemical waste and easy work-up procedure.

Keywords: Aromatic aldehyde, Ethyl acetoacetate, Phenyl hydrazine, Monosodium Glutamate.

PP-172

Structural, Vibrational and Thermal studies of Glutamine doped LaF3: Dy nanoparticles for Biological Applications.

Shirish B. Patil1, S.S. Dongare2, M. M. Khandpekar3 and A. T. Singh4

1Department of Physics, K G Karjat College of ASC, Karjat, Raigad-410201, India. 2Department of Physics, JSM’s SGASGPC College,Shivle, Murbad, Thane-421401, India. 3Department of PhysicsBirla College of Arts, Commerce and Science Kalyan (W).Thane-421304,India. 4Department of Physics, K. M. Agrawal College,Kalyan (W).Thane-421301,.India.

*Corresponding author:[email protected]

Abstract: Coprecipitation method has been used to synthesize water soluble nanoparticles of Glutamine doped LaF3:Dy using chlorides of Lanthanum and dysprosium along with ammonium fluoride and glutamine.The structural studies have been done using X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy(TEM), EDAX and SAED pattern. The vibrational studies were done using FTIR and FT-RAMAN Spectroscopy. The vibrational studies gave the peaks indicating the organic functional group attachments on the core LaF3:Dy molecules. The thermal studies have been done using Thermo gravimetric analysis (TGA) and Differential Thermal Analysis (DTA). The thermal analysis gave the stability of the synthesized nanoparticles.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 120 Exploring New Horizons in Chemical Sciences-2019

PP-173

Effect of chromium substitution in nickel ferrite nanoparticles on structural and thermoelectric properties Ram S. Barkulea, D.R. Shenguleb, K.M. Jadhavc aDepartment of Physics, S. M. College of Arts, Commerce and Science, at Cholai, Poladpur, Raigad, (M.S.), India -402303 bDepartment of Physics, Vivekanand Arts, Sardar Dalip Singh Commerce and Science College, Auragabad, (M.S.), India - 431001 c Department of Physics, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, (M.S.), India- 431004 *Corresponding author: [email protected] Abstract: Aluminum substituted nickel ferrite having generic formula NiCrxFe2-xO4 (0 ≤ x ≤1.0) has been synthesized by sol-gel auto combustion technique using high purity nitrates. The X-ray diffraction patterns (XRD) were recorded at room temperature to determine the structure of chromium substituted nickel ferrite nanoparticles. The samples confirmed single phase spinel structure. Thermoelectric power (α) measurement studies were carried out over a temperature range 300 K- 475 K by the differential method. The temperature difference between two ends of the sample was kept at 10 K throughout the temperature range studied. Electrical transport properties of aluminum substituted nickel ferrite been investigated from room temperature to well beyond the Curie temperature. Based on the Seebeck coefficient the ferrites under investigation have been classified as P-type semiconductors.

Keywords: Spinel ferrite, thermoelectric properties.

PP-174

A Review: Common milk adulteration and their detection techniques S. P. Gawali1, M. R. Walle2 Department of chemistry, Sundarrao More College of Art’s, Commerce and Science, Poladpur, Poladpur - Raigad-402303

*Corresponding author:[email protected] Abstract: Milk is a nutritious dairy product and it’s consumed by a majority of the population worldwide for drinking as such, as well as via dairy products. The gap between production, consumption and inability of regulatory authorities to check adultarion to make easy money through the adulteration, at the cost of health and nutrition of consumers. A large number of research papers have been published on milk adulteration and detection including some review papers. This paper to review on some common milk adulterants, on methodologies adopted to adulterate the milk and the health hazards related to the adulteration. This review intends to contribute towards the common knowledge base regarding possible milk and their detection techniques.

Keywords: Milk, Adulteration, Adulterants, Detection techniques, Health hazards.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 121 Exploring New Horizons in Chemical Sciences-2019

PP-175

Analysis of soil samples for its physicochemical parameters from Ladawali Mahad.

Snehal Kamble

Dept.of Chemistry, Sundarrao More College of Arts Commerce and Science Poladpur, Raigad 402303 (MS) India.

*Corresponding author: [email protected]

Abstract: In the present investigation the physicochemical study of soil is based on various parameters like total Organic Carbon, Phosphorus (P2O5), Potassium (K2O), pH and Conductivity. This study leads us to the conclusion of the nutrient’s quantity present in soil of Ladawali, Tal Mahad District Raigad (Maharashtra). In order to study the effect of phosphate fertilizer, phosphorus to increase percentage yield of crops. This information will help farmers to solve the problems related to soil nutrients, amount of which fertilizers to be used to increase the yield of crops.

PP-176 Separation and Quantification of Structurally Similar Impurities by HPLC Method of Vortioxetine hydrobromide- An antidepressant drug

Shashikant B. Landge,a Sunil B. Dahale,a Sachin J. Devadhe,a Dattatray G. Deshmukh,a Pavankumar V. Solanki,a Sanjay A. Jadhava and Saroj R. Bembalkarb aDepartment of Process Research and Development, Megafine Pharma (P) Ltd., 201, Lakhmapur, Dindori, Nashik-422 202, Maharashtra, India, bDepartment of Chemistry, Deogiri College, Aurangabad, 431005, India.

*Corresponding author: [email protected]

Abstract: A new, specific, and robust normal phase liquid chromatographic (NP-LC) method for the determination of structurally similar Impurities (Positional Isomers) of Vortioxetine hydrobromide has been developed and validated. The good chromatographic resolution between the structurally similar Impurities (Positional Isomers) and Vortioxetine hydrobromide was achieved on Chiralpak-ADH(250 x 4.6mm ID), 5µ column.The mobile phase was consisting of n-hexane, ethanol, diethyl amine, and Trifluoroacetic acid in the ratio (75:25:0.05:0.05,v/v/v/v) and the flow rate was maintained at 1.0 mLmin-1. UV detection was carried out at 235nm. The resolution between all positional isomers and Vortioxetine hydrobromide was found not less than 2. An effect of column oven temperature on resolution was also studied and found to be ≥ 2.0. Three structurally similar Impurities (Isomer-1, Isomer-2, and Isomer-3) have been detected in test sample of Vortioxetine hydrobromide by developed NP-LC method. Further, these isomeric impurities were characterized by mass spectrometry, 1H NMR and FT-IR spectral data.The developed method was validated as per ICH guide line and found to be specific, robust, and selective. This developed NP-LC method was successfully applied to the analysis of drug substance and drug product samples of Vortioxetine hydrobromide.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 122 Exploring New Horizons in Chemical Sciences-2019

PP-177 Synthesis of 1, 8-dioxooctahydroxanthene and 3, 3 Arylindene Bis (4- hydroxycoumarin) derivatives using efficient and reusable catalyst in aqueous medium.

Walle M. R.a, Kamble S.S.a, Pawar R. P.b aDepartment of Chemsitrty, Sundarrao More Arts, Commerce, Science college, Cholei, Poladpur (MS) India. bDepartment of Chemsitrty, Deogiri college, Aurangabad (MS) India.

*Corresponding author: [email protected] Abstract: A rapid, green and efficient method for the synthesis of 1,8-dioxooctahydroxanthene derivatives and 3,3 Arylindene Bis (4-hydroxycoumarin) through a one-pot condensation with various aromatic aldehydes in the presences of efficient and reusable catalysts. Catalyst used under solvent-free conditions and can be recovered and reused. Compared with other synthetic methods, this new method has advantages such as milder reaction conditions, good to excellent yields, short reaction times, and environmentally benign procedure.

Keywords: Solvent-free; 1, 8-Dioxooctahydroxanthene; 3, 3 Arylindene Bis (4-hydroxycoumarin); reusable catalyst

PP-178

A Study of Adsorption on textile dye Using Tamarind Pod Shells.

G. C. Upadhye, V. H. Singh. K. K. Gadge Department of chemistry, Konkan Gyanpeeth, Karjat College of A.S.C., Karjat, Raigad, Maharashtra.

*Corresponding author:[email protected] Abstract: In the present study, agriculture waste tamarind (Tamarind us indica) pod shells were used for adsorption of M-Navy Blue dye. The variables studied were initial concentration, initial PH, adsorption dosage and contact time. The experimental data obtained were fitted to Freundlich and Langumur adsorption isotherms. The maximum adsorption of M-Navy Blue is 71.04 mg/g of the adsorbent. The optimum PH for the adsorption of dye in the range of PH 6-12.The tamarind pod shells is an excellent low cost adsorbent for the removal of dye from waste water effluents. The kinetic study shows that it follows a pseudo first order kinetics.

Keywords: Dye adsorption, M-Navy Blue, tamarind pod shells, Low cost adsorbent, Kinetic study.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 123 Exploring New Horizons in Chemical Sciences-2019

PP-179 Synthesis of 1-H indazole using Lemmon peal powder as an efficient catalyst Swati S. Ghodke1, R. D. Ingale1, P. M. Khandare1, Akshay Takwale2, R. P. Pawar1*

1Department of Chemistry, Deogiri College, Aurangabad. 2Korean Research Institute of Chemical Tecnhology, Yusong-gu, Korea.

*Corresponding author: [email protected]

Abstract: Bioactive 1-H indazole has been synthesized from 2-substituted aromatic aldehyde and hydrazine hydrate using DMSO and efficient catalyst.

Keywords: 2-Substituted aldehydes, hydrazine hydrate, catalyst and DMSO.

PP-180

Review on “Analysis of Drinking Water of Different Places’’

S. A. Peerzade1*, A. J. Khan1, Mazhar Farooqui, 2 Sayed Abed 3

1. Department Of Chemistry, Milliya Arts Science & Management Science College Beed Maharashtra State India Pin Code 431122 2. Department Of Chemistry, Dr. Rafiq Zakaria College for Women Aurangabad, Maharashtra, India 3.Department Of Chemistry,Government College of Arts & Science Aurangabad, Maharashtra, India

*Corresponding author: [email protected] Abstract: The study is based on the analysis of drinking water parameters in an educational institute situated in Hingna MIDC area in Nagpur District Maharashtra India. In these study different authors papers are summarized on water analysis & their treatment processes in different region which is helpful to know the different treatment processes & Parameters used in the study. Drinking water samples were collected from different area. After collection of different samples, different parameters like PH. Total alkalinity, Total hardness, chloride, sulphate, Flouride, Total Dissolved solid, conductivity, cabondioxide, Calcium, etc. were studied. Result showed that seasonal variation in water parameters at different area. The chemical analysis of water was carried out in the light of APHA (1985) & compared with WHO ICMR & ISI standard.

Key words: Drinking water, alkalinity, sulphate, TDS, Total hardness, Water quality, APHA, WHO

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 124 Exploring New Horizons in Chemical Sciences-2019

PP-181

Potentiometric Study of Nicotinic acid (Vit B3) complexes with transition metal ions S. T. Dengle a, A. S. Rajbhojb* aDepartment of Chemistry, Vivekanand Arts, S.D. Commerce and Science College Aurangabad-431002 (M. S.) India. b*Department of Chemistry, Dr.Babasaheb Ambedkar Marathwada University, Aurangabad-431005 ( M. S.) India. *Correspondence author: [email protected]

Abstract: The stability constants of Nicotinic acid (vitamin B3) complexes with transition metal ions V(II), Cr(II), Fe(III), Co(II), Ni(II), Cu(II) & Zn(II) were determined pH metrically for various ionic strengths 0.1M, 0.3M & 0.6M NaClO4.The temperature 298K maintained constant.The stability constants of Nicotinic acid (vitamin B3) and transition metals ie pK1 and logK1 have been calculated and studied.

PP-182 Synthesis of (±)-Baclofen M. D. Nikalje,1 P. A. Kulkarni,2 M. N. Lokhande,3 R. G. Shinde,1 D. R. Birhade*2 1Department of Chemistry, S. P. Pune University, Pune 2Department of Chemistry, Yeshwant Mahavidyalaya, Nanded 3Department of Chemistry, Avvaiyar Govt. College for Women, Karaikal. *Corresponding author: [email protected] Abstract: Glutamate and GABA are the most abundant neurotransmitters in the central nervous system, and especially in the cerebral cortex, where thinking occurs and sensations are interpreted. Glutamate acts as an excitatory neurotransmitter while GABA does the opposite.

COOH NH2 NH HOOC COOH H2N COOH 2

Glutamate GABA Cl (R,S)-Baclofen

Figure 1 Baclofen is an analog of GABA, but unlike GABA, it can cross the blood brain barrier. Baclofen is the reference selective agonist for the GABA receptor, and racemic baclofen is widely used as an antispastic agent.Baclofen is the one most important lipophilic derivative of GABA acts as an inhibitory neurotransmitter in central nervous system. The excitatory effect of active compounds such as benzodiazepine, barbiturates, etc. can be reduced with the help of Baclofen. Baclofen is also one of the most promising drugs in the control and treatment of the paroxysmal pain of trigeminal neuralgia as well as spasticity of spine without influencing the sedation. So we decided to design a simple, general and sustainable protocol for the synthesis of Baclofen and here we developed the same. Here, we reported a new methodology for the preparation of Baclofen using Wittig-Claisen olefination methodology starting from p-chloro benzaldehyde.

COOH

CHO NH2

Cl Cl

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 125 Exploring New Horizons in Chemical Sciences-2019

PP-183 Synthesis of 2-Amino-4[H]chromenes and their antimicrobial activity. Priya M. Khandare1, Rajita D. Ingle1 S. N. Salve 1, A.pukale2 Rajendra P. Pawar1* 1Department of Chemistry, Deogiri College, Station Road, Aurangabad - 431 005 (MS) - India. 2Dr.Babasaheb Ambedkar College, Mahad, Dist. Raigad-402301

*Corresponding author:[email protected] Abstract: A simple and one pot synthetic protocol for the synthesis of bioactive 2-Amino-4[H]chromene compounds at room temperature in H2O has been developed using An efficient catalyst. This method provides operational simplicity and environment friendly green approach.

Keywords: Chromene, Antifungal activity.

PP- 184

Rapid and Efficient one pot synthesis of polyhydroquinoline derivatives through the Hantzsch condensation by bleaching earth clay and PEG-600

Giribala M. Bondle, Sandeep T. Atkore*

Department of Chemistry and Department of Biochemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004,Maharashtra, India *Corresponding author:[email protected]

Abstract: Polyhydroquinoline derivatives have been efficiently prepared via one-pot condensation of ethyl acetoacetate, dimedone, ammonium acetate andthe appropriate aromatic aldehyde in the presence of Polyethylene glycol (PEG-600) as green reaction solvent under microwave irradiation by using bleaching earth clay catalyst. The procedure provided the target compounds in excellentyield and purity with a facile work-up procedure. O R O O O O MW, PEG-600 OEt R CHO OEt NH4OAc O bleaching earth clay 1 2 N 3 4 H 5a-l Keywords: Polyhydroquinoline, One-pot, Microwave, Aromatic aldehydes, Bleaching earth clay, PEG- 600

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 126 Exploring New Horizons in Chemical Sciences-2019

PP-185

Synthesis, Characterization and Antibacterial Activityof mixed Cobalt- Transition metals Compounds.

C. S. Patila*, N. S. Dhavaleb, V. B. Tadkeb, S. M. Vhankateb, S.S. Pawarb, and S. K. Dhanmaneb aChemistry Department Deogiri College, Aurangabad, Maharashtra bChemistry Department, Fergusson College Pune, Maharashtra

*Corresponding author: [email protected] Abstract: Solid mixed metal complexes were synthesized by conventional method using bidentated tartrate ligand. When ligand treated with corresponding transition metal salts in a molar proportion it forms metal complexes in the ratio of [M1M2(T)3] xH2O, Where M1 = Cu(II), Zn(II) or Cd(II), M2 = Co(II), x = no. of H2O molecules and the ligand T= Tartrate. These metal complexes were characterized by elemental analysis, X-ray diffraction, AAS, IR spectroscopy as well as by TGA. On the basis of these studies, it is proposed that tartrate ion act as a bidentate ligand and co-ordinate to metal through donor oxygen of COO- group. The ligand as well as metal complexes has been screened for their antimicrobial activity against Escheriachia Coli, Bacillus Subtillis, Staphylococcus Aureus etc and results are discussed.

Keywords: Bidentated, Tartrate, Antimicrobial

PP- 186

Synthesis and spectroscopic characterization of transition metal complexes of a 14-memberd tetraza [N4] macrocyclic ligand

S. S. Patil and S. G. Shankarwar Department of chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, Maharashtra, India.

*Corresponding author:[email protected]

Abstract: The metal complexes of Mn[II], Fe[III], Co[II] and Cu[II] have been synthesized with newly synthesized biologically active macrocyclic ligand. The ligand was synthesized by condensation of β- diketone 1-(3-chlorophenyl)-3-(2-hydroxyphenyl) propane-1,3-dione and O-phenyl diamine. All the complexes were characterized by spectral and other physic-chemical techniques such as elemental analysis, molar conductivity, magnetic susceptibility, thermal analysis, X-ray diffraction, FT-IR, 1H- NMR, UV-Visible spectroscopy and mass spectroscopy. From the analytical data, the stoichiometry of complexes was found to be 1:2 (metal : ligand). Thermal behavior (TG-DTA) and kinetic parameters were calculated by Horowitz-Metzer and Coats-Redfern method suggested more ordered activated state in complex formation. All the complexes are of high spin type and six co-ordinated, on the basis of FT- IR, electronic spectral studies and magnetic behavior; an octahedral geometry has been assigned to these complexes. The anti-bacterial and anti-fungal activities of the ligand and its metal complexes, has been screened in vitro against Staphylococcus aureus, Escherichia coli and Aspergillus niger, Trichoderma respectively.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 127 Exploring New Horizons in Chemical Sciences-2019

PP-187

Synthesis and antibacterial activity of new 2-amino substituted pyrimidines

C. U. Dhanwad1, V N Kale2, P A Kulkarni1, Yogesh S. Nalwar3, G. S. Waghmare1 *. 1PG Department of Chemistry, Yeshwant Mhavidaylaya Nanded. 2PG Department of Chemistry, Degloor College Degloor. 3Toshniwal ACS College, Sengaon, Hingoli. *Corresponding author:[email protected].

Abstract: New 4-([1, 1’-biphenyl]-4-yl)-6-(4-isopropylphenyl) pyrimidin-2-amine have been prepared by the reaction of (E)-1-([1, 1’-biphenyl]-4-yl)-3-(4-isopropylphenyl) prop-2-en-1-one and Gaunidine hydrochloride in presence of KOH in methanol. The compound (E)-1-([1, 1’-biphenyl]-4-yl)-3-(4- isopropylphenyl) prop-2-en-1-one was synthesised from 4- acetyl Biphenyl and 4- isopropyl benzaldehyde in 10 % KOH in methanol. All the synthesised compounds were characterised by spectroscopic analysis. Synthesised chalcone, pyrimidine and its derivatives were screened for antibacterial activity against S.aureus and E.coli, exhibited good activity.

Keywords: 4-Acetyl Biphenyl, Chalcone, Gaunidine hydrochloride Pyrimidine.

PP-188

A novel method for protection of diols using iodine and dimethoxypropane

Ravibhushan S. Kulkarni, Praful P. Ingle, Radhakrishnan M. Tigote, Kishan P. Haval*

aDepartment of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Sub Campus, Osmanabad 413501 (MS) India

*Corresponding author: [email protected]

Abstract: The protection and cleavage of isopropylideneacetals are important aspect in the chemistry of carbohydrates, nucleosides and alkaloids. As a result, numerous methods using acid catalysts have been developed. Herewith, we have reported novel method for protection of diol as an acetonide using iodine and dimethoxypropane. The ease of handling, cost and activity of the catalyst, good to excellent yields and neutral reaction conditions are some of the highlights of the reported method.

Keywords: Acetonide, Diol protection, Iodine, Dimethoxypropane, Green chemistry.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 128 Exploring New Horizons in Chemical Sciences-2019

PP- 189

Synthesis, characterization and evaluation of some new substituted 2-phenoxynicotinaldehydes as an α-amylase inhibitor

Ravibhushan S. Kulkarni,aNitin B. Haval,aJitendra A. Kulkarni,bPrashant P. Dixit,cKishan P. Havala* aDepartment of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, SubCampus, Osmanabad 413501 (MS) India bDepartment of Biotechnology, Dr. Babasaheb Ambedkar Marathwada University, SubCampus, Osmanabad 413501 (MS) India cDepartment of Microbiology, Dr. Babasaheb Ambedkar Marathwada University, SubCampus, Osmanabad 413501 (MS) India

*Corresponding author: [email protected] Abstract: Diabetes mellitus is a chronic endocrine disorder that affects the metabolism of carbohydrates, proteins, fat, electrolytes and water.α-Amylaseand α-glucosidase are the important enzymes required for the digestion of the carbohydrate. These enzymes plays a vital role in the breakdown of starch in the diet and its activity has been correlated to postprandial blood glucose levels, the control of which is essential for maintaining quality of life for diabetic patients. Herewith, we are reporting the synthesis, characterization and biological evaluation of some new substituted 2-phenoxynicotinaldehydes as anα- amylase inhibitors.

Key words: Diabetes, α-Amylase, α-Glucosidase, 2-Phenoxynicotinaldehydes.

PP- 190

Synthesis Characterization and Antimicrobial, Antioxidant Activity of Some Novel Pyrazolines

G. B. Rahatikara, Ravi R. Viduleb, S. N. Lakhekarb, M. A. Baseerb*

*b,aP.G. Research Center, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602.

*Corresponding author: [email protected]

Abstract: Some substituted N-acetyl pyrazoline derivatives were synthesized from appropriate substituted 1,3- diphenyl 2-en-1-one (chalcone) on reaction with hydrazine hydrate, acetic acid and KOH in ethanol. The synthesized compounds were structurally elucidated on the basis of IR, 1H-NMR and Mass spectral data. All of the synthesized compounds were screened for their antimicrobial and antioxidant activity. Few compounds show moderate result.

Keywords: N-Acetyl pyrazoline, Antimicrobial, Antioxidant activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 129 Exploring New Horizons in Chemical Sciences-2019

PP- 191

Synthesis and Antimicrobial Activity of 1-(2’Hydroxy-3’/5’-chloro-5’/3’- chloromethylphenyl)-3-(aryl/heteroaryl)-2-propen-1-ones.

K. G. Huge*1,2, V. M. Gurav2, K. R. Borude1, S. U. Tekale3

1 K.K.M. College, Manwath. Dist. Parbhani, Maharashtra, India-431505 2Yeshwant College, Nanded, Maharashtra, India- 431602 3Deogiri College, Aurangabad, Maharashtra, India - 431005.

*Corresponding author: [email protected]

Abstract: A series of ten chalcones with chloromethyl group were synthesized from trisubstituted acetophenones with chloromethyl group as one of the substituent in high yield and purity by Claisen-Schemidt condensation.The structure of these compounds are confirmed by taking IR, H1- NMR & Mass spectra of the representative member of series and these compounds are screened for antibacterial and antifungal activities against selected human and plant pathogens.

Keywords: Claisen-Schemidt condensation, Chloromethyl chalcones, trisubstituted acetophenone, antibacterial and antifungal activity.

PP- 192

Kinetics of Isothermal Annealing of Gamma-Irradiated Eutectic Mixture of NaNO3-KNO3

S. S. Pawar1 and S. F. Patil2 1) Department of Chemistry, Fergusson College (Autonomous), Pune-411004, Maharashtra, India. 2) Ex-Professor, Department of Chemistry, Savitribai Phule Pune University, Pune 411007, Maharashtra, India.

*Corresponding author: [email protected]

Abstract: Considerable amount of work has been reported on isothermal annealing of pure alkali and alkaline earth metal nitrates. In the present work, initially, the eutectic of NaNO3-KNO3 was prepared by mixing 0 NaNO3 (45%) and KNO3 (55%) fused at 225 C and cooled naturally. The samples of eutectic of 60 NaNO3-KNO3 were irradiated in Co – gamma source. The radiation decomposition of eutectic mixture takes place. Present work mainly deals with the study of isothermal annealing of radiation damage in eutectic mixture of NaNO3-KNO3. This data has been analyzed by using conventional kinetics and the Waite Model. Results of annealing show that a major fraction of annealing obeys second order kinetics except in the initial short period. The energies of activation are calculated by two methods and are found to agree.

Key Words: Annealing, Kinetics, Gamma-irradiation, Eutectic of NaNO3-KNO3.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 130 Exploring New Horizons in Chemical Sciences-2019

PP- 193

Studies of stability Constant of mixed ligand complexes of bio-molecules and amino acids with Cu (II) by potentiometric titration method

Rajendra P. Phase1*, Anil G. Shankarwar2, Sanjay S. Kotalwar3, Vasant B. Jagrut4 *1,3 Department of Chemistry, L. B. S. Sr. College, Partur 431501, (M.S) (India) 2 Department of Chemistry, S. B. E. S. College of Science, Aurangbad, (M.S) (India) 4 Department of Chemistry, S. V. Sr. College, Mantha, (M.S) (India)

*Corresponding author: [email protected] Abstract: The stability constant of (1:1:1) ternary chelates of bivalent Cu(II) metal ion with some Biomolecules (drugs) as primary ligand and amino acids as secondary ligand have been carried out in 20% (v/v) H O ethanol-water medium p - metrically at 30 C and 0.1 M (NaClO4) ionic strength. The stability constant of binary complexes ML and ML2 are also determined under similar experimental conditions. The stability constant of ternary complexes are evaluated and their relative stabilities compared to the corresponding binary complexes are expressed in terms of Statistical parameters ΔlogK, KR, KL and Kr. Formation of complex species with respect to pH have been discussed by Irving-Rossoti technique and evaluated by using the computer SCOGS program.

Keywords: Biomolecules, binary complex, ternary complex, stability constant, SCOGS.

PP- 194 Synthesis, Characterization and Antimicrobial Analysis of Some New Schiff Bases

Amol J. Shirsat1, Sunil S. Bhagat1, Balaji D. Rupnar1, Ajit K. Dhas2, Prashant Dixit3, Gopal K. Kakade4*

1Department of Chemistry, R. B. Attal Arts, Science & Commerce College, Georai, Beed, Maharashtra, India. 2Department of Chemistry, Deogiri College, Aurangabad, Maharashtra, India. 3Department of Microbiology, Dr. Babasaheb Ambedkar Marathwada University Sub-Center, Osmanabad, Maharashtra, India. 4Department of Chemistry, Arts, Commerce & Science College, Kille- Dharur, Beed, Maharashtra, India. *Corresponding author: [email protected] Abstract: Schiff bases are generally one of the most commonly used organic moieties. They shows wide variety of applications in diverse fields including biological, analytical and inorganic chemistry they used as catalysts, pigments and dyes, intermediates in organic synthesis. Herein we report novel fluorine containing Schiff bases from 3-(5-bromothiophen-2-yl)-1-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde and fluoroaniline. All synthesized Schiff bases were well characterized by spectral analysis and were screened for antimicrobial activity and they showed moderate activity.

Keywords: Schiff bases, Pyrazole aldehyde, Fluoroaniline, Antimicrobial, Gram +ve and Gram –ve microorganisms.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 131 Exploring New Horizons in Chemical Sciences-2019

PP-195 Green Synthetic Approach for the Synthesis of Quinazoline Schiff Bases using p-TSA under Microwave Irradiation in Ethanol Balaji D. Rupnar*a, Vijay P. Pagoreb,c, Sunil S. Bhagata, Amol J. Shirsata, Ajit K. Dhasb, Rajendra P. Pawarb aDepartment of Chemistry, R. B. Attal College Georai, Dist- Beed-431127 (MS) India bDepartment of Chemistry, Deogiri College Aurangabad-431005 (MS) India. cDepartment of Chemistry, Shri Muktanand college, Gangapur, 431109 (MS) India.

*Corresponding author: [email protected]

Abstract: Quinazolines and quinazolinones, as nitrogen-rich heterocycles represent a unique class of diversified frameworks exhibiting a broad spectrum of biological functions. Recently intensive medicinal chemistry efforts have generated numerous structurally functionalized quinazoline and quinazolinone derivatives. In early years, the use of solid acid catalyst has gained importance in organic synthesis because of their several advantages such as operational simplicity, low cost, non-toxicity, reusability, and easy isolation after completion of the reaction. Herein we have developed a green protocol for the synthesis of Quinazoline Schiff bases using p-TSA as solid acid catalyst from benzhydrazide and various aromatic aldehyde under microwave irradiation in ethanol. All the synthesized Schiff bases are well characterized by various spectroscopic techniques and compared with reported methods. Compared to previously reported methods, moreover, the mild reaction conditions, easy work-up, clean reaction profiles, lower catalyst loading and cost efficiency render this approach as an interesting alternative to the existing methods.

PP- 196

Synthesis, and Antibacterial activities of Newer6-(3-(1, 2-dihydro-6-phenyl-2- aminopyrimidin-4-yl)phenylamino) pyridazin-3(2H)-one

Shrikrishna D. Tupare1, Santosh D. More2, Sanjay K. Vyawahare2, R. P. Pawar3 1Department of Chemistry, K. E. S. Anandibai Pradhan Science College, Nagothane Tal. Roha Dist. Raigad. M.S. India- 402106. 2 Department of Physics, Deogiri College, Aurangabad MS India- 431005. 3 Department of Chemistry, Deogiri College, Aurangabad MS India- 431005. *Corresponding author:[email protected] Abstract: Several substituted pyridazone derivative of Acetophenone are condensed with aromatic aldehydes, and resulting Chalcones are used for the synthesis of Diarylpyrimidines. Organic compounds containing pyrimidines, thiopyrimidines as a core unit are known to exhibit various biological activities and pharmaceutical activities. So, allnewly synthesized compounds were screened for their antibacterial activity. Most of the compounds showed significant antibacterial activities.

O O HN NH HN 2 N O N N N HN NH KOH HN + H2N NH2 Ethanol

R R 1 2 3

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 132 Exploring New Horizons in Chemical Sciences-2019

PP- 197

Oxidation of Unusual groups using Periodate in Homogeneous and Phase Transfer Condition. Dr. J. H. Deshmukha Dr. S. G. Patilb aMahatma Basweshwar Mahavidlaya, Latur bMaharashtra Udaygiri Mahavidyalaya,Udgir. *Corresponding author:[email protected]

Abstract: In the present article we report oxidation of some unusal gropus using periodate under homogenopeus and phase transfer conditions. Oxidation of sulphides, 2-hydroxyacids, 2-bromoketones and arylacetic acid was not easily oxidized, for that we have used tetrabutylammonium periodates [TBAPI]. Earlier researcher for oxidation of benzylic halides used sodium chromate in HMPA or Potassium Dichromate in polyethylene glycols or bis[tetrabutyl ammonium chromate ] but during this there is nucleophilic displacement of halides will forms chromate ester which further forms carbonyl compounds.

PP- 198 “Valorization of biomass byproducts to pharmaceutical compounds: acid- catalyzed or solvent free synthesis of glycerol derivatives with antifungal activity by grinding at room temperature”

Suresh U. Shisodia1, Attilio Citterio.1* 1Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy. *Corresponding author: [email protected]

Abstract: In recent years development of environmentally friendly chemical synthesis is gaining considerable interest both in academia and industrial research. In this context, the replacement of toxic and volatile organic reagents and solvents as reaction media with environmentally acceptable alternatives such as chemicals from renewable resources (biomass products) are preferable. Polyfunctional molecules that are C-3 natural polyols like glycerol or its derivatives such as glycerol carbonate and diglycerol, serinol, iso-serinol have been proposed as valuable starting materials for synthesis of pharmaceutical compounds, monomers and polymers. Glycerol, in particular, has potential as green solvent for catalysis, organic synthesis, separations and materials chemistry,1 but can also be converted into value- added new chemicals.2 In this context we have focused our attention on the valorization of glycerol/glycerol derivatives3 in green conditions, with or without catalyst and solvent in mild conditions. The direct high-yield synthesis of mono, di and tri substituted ferrocenyl methyl ethers and their derivatives from ferrocenemethanol and vicinal oxygenated alcohols (derived from biomass) without solvent in presence of acidic catalyst at room temperature, by grinding method is reported here. The peculiar ability of these classes of non acidic compounds to favour the dehydrative nucleophilic substitution is attributed to the presence of vicinal oxygen atoms to the reactive group able to build a hydrogen bonding network with the reactant4. The in vitro anti-fungal activity of some of these derivatives was investigated on plant fungi, and found moderate to good activity.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 133 Exploring New Horizons in Chemical Sciences-2019

PP- 199 Synthesis, Characterization and Antioxidant Activity of New Halogen substituted Chalcones

S. N. Lakhekar, G. B. Rahatikar, M. A. Baseer P.G. Research Center, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602. *Corresponding author: [email protected] Abstract: In the recent century, chalcones are found to be fundamental constituents of heterocyclic compounds viz., pyrazolines, pyrimidines, pyridines, isoxazolines, flavones, flavonols, benzodiazepines, benzothiazepines. In the present work, a series of chalcones were synthesized by Claisen-Schmidt base catalysed condensation of suitable halogen substituted hydroxy acetophenones with different aromatic aldehydes and assessed for their anti-oxidant activity. Their synthesis was monitored by TLC and compounds synthesized were purified by recrystalization, further confirmed by IR, MASS ,1 H-NMR spectroscopic analysis. Keywords: Chalcones, Claisen -Schmidt Condensation, Antioxidant

PP-200

Preparation and investigation of Photophysical, Electrochemical and Thermal properties of pyrene doped 2-naphthol luminophors for optoelectronic devices

K. G. Mane1, P. B. Nagore1, S. R. Pujari*

1Doshi Vakil Arts & G.C.U.B. Sci. & Comm. College, Goregaon-Raigad-Maharashtra-India-402103 *D.B.F.Dayanand College of Arts and Science, Solapur-Maharashtra-India-413002.

*Corresponding author: [email protected]

Abstract: A new series of pyrene doped 2-Naphthol luminophors were prepared using conventional solid state reaction technique. These novel luminophors emits at longer wavelength. Their optical properties were studied by fluorescence spectroscopy while the electrochemical properties were studied by cyclic voltammetry technique. Sharp peaks in XRD revealed the crystallinity and homogeneity of the doped luminophors. The fluorescence spectrum of doped 2-naphthol with 1x10-3 mole pyrene shows structured monomeric emission of pyrene. The increased addition of pyrene enhances the pyrene emission towards longer wavelength side. The broad fluorescence band of 2-naphthol containing 1x10-1 mole pyrene is centered at 451 nm. The excitation energy transfer (EET) process is observed from host 2-naphthol to the pyrene. Electrochemical data reveals that the HOMO and LUMO energy levels of the prepared luminophors are well in the range of 5.70–5.72 eV and 3.02–3.09 eV, respectively. TGA-DSC analysis confirmed the thermal stability of prepared luminophors. So, that’s confirmed that prepared luminophorsare promising candidate for optoelectronic devices.

Keywords: EET, Monomeric emission, Luminophors, Optoelectronic device

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 134 Exploring New Horizons in Chemical Sciences-2019

PP-201

Synthesis, Characterization and Antioxidant Activity of New Halogen substituted Chalcones

S. N. Lakhekar, G. B. Rahatikar, M. A. Baseer P.G. Research Center, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602. *Corresponding author: [email protected] Abstract: In the recent century, chalcones are found to be fundamental constituents of heterocyclic compounds viz., pyrazolines, pyrimidines, pyridines, isoxazolines, flavones, flavonols, benzodiazepines, benzothiazepines. In the present work, a series of chalcones were synthesized by Claisen-Schmidt base catalysed condensation of suitable halogen substituted hydroxy acetophenones with different aromatic aldehydes and assessed for their anti-oxidant activity. Their synthesis was monitored by TLC and compounds synthesized were purified by recrystalization, further confirmed by IR, Mass, 1 H-NMR spectroscopic analysis.

Keywords: Chalcones, Claisen-Schmidt condensation, Antioxidant

PP- 202 Synthesis and Antifungal Activity of Novel 1, 2, 3-Triazole Linked 2-Amino-4- aryl-6-(phenylsulfanyl)-3, 5-dicyanopyridines

Smita P. Khare,1Jaiprakash N. Sangshetti,2 Bapurao B. Shingate*1 1Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431 004, India. 2Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, 431 001, India.

*Corresponding author: [email protected]

Abstract: Heterocyclic compounds are widely distributed in nature and also present in variety of drug molecules. Among the heterocyclic compounds, pyridine is one of the important heterocyclic scaffolds.1Specifically, 3-cyanopyridines possess diverse biological activities like PIM1 kinase inhibitor, anticancer, Aurora A kinase inhibitor and phosphodiesterase3 (PDE3) inhibitor. In recent years,triazole chemistry has evolved to a great extentdue to its important pharmacological properties.2In the present work, a series of novel triazole linked 2-amino-4-aryl-6-(phenylsulfanyl)-3,5- dicyanopyridines have been synthesized via multicomponent reaction approach will be presented. All the newly synthesized compounds were evaluated for their in vitro antifungal activity and showed good to excellent activity with lower MIC value.

Keywords: 1, 2, 3-Trizole; Dicyanopyridines; Multicomponent reactions; Antifungal activity

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 135 Exploring New Horizons in Chemical Sciences-2019

PP- 203 Synthesis of flavones and there equivalent using Aldehyde and Acetophenone by conventional and non-conventional methods

R. S. Mirgea, S. R. Bembalkarb a Department of Chemistry, Yeshwantrao Chavan College, Sillod, Aurangabad, MS, India 431005 b Department of Chemistry, Deogiri College, Aurangabad, MS, India 431005 *Corresponding author: [email protected], [email protected] Abstract: Flavonoids are important natural biological moiety many researcher works on this moiety majority of the data is on the role of flavonoids as antioxidant agent and interaction between plant and insect. Flavonoids are the group of Phenolic compound widely present in plant kingdom and shows different biological activity like antioxidant, antifungal, neuron transmitter etc.The synthesis of flavonoids and there equivalent have been reported in excellent yield. In this article we are discuss about the synthesis of flavones by conventional and non-conventional methods which gives excellent yield. Synthesis of flavones and there Equivalent are prepared separately by conventional and non-conventional routes with different product yield is reported. The substituted Aldehyde and Acetophenone gives chalcones in excellent yield at room temperature by conventional method. These chalcones gives flavones by cyclisation in better yield by non-conventional method. (Grinding). In two step flavones are synthesized, in first step conventional (magnetic stirrer) gives chalcones and second step cyclisation of chalcones by non-conventional methods (grinding) gives flavones. O O O O H Grinding NaOH R OH R - H2O I2 O OH R O-Hydroxyacetophenone Substituted benzaldehyde Chalcones Flavones X Y z PP- 204

A 8-hydroxypyrene-1, 3, 6-trisulfonic acid trisodium salt (HPTS) basedcolorimetric and green turn-on fluorescent sensor for the detection of arginine and lysine in aqueous solution. Ganesh V. Shitrea,b, Praveen V. Shitrec, Krishna Keleb, Parmeshwar Shendgeb, Rajesh S. Bhosalea*, Sidhanath V. Bhosalea* aPolymers and Functional Material Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007 Telangana, India. bVaishnavi Mahavidyalaya, Wadwani, Beed, 431144. cYeshwantrao Chavan Mahavidyalaya, Sillod, Aurangabad 431112.

*Corresponding author: [email protected], [email protected]

Abstract: Amino acid is the organic compound in which amine and carboxylic group bonded with α-carbon atom. There are twenty natural amino acids are present in the nature, among the all amino acids arginine (Arg)and lysine (Lys) are plays crucial role in many biological processes.Here in use of 8- hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) as a colorimetric and green turn-on fluorescent probe for the recognition of arginine and lysine in aqueous solution. Competitive studies indicatedthat HPTS can recognise Arg and Lys even in the presence of several other amino acids. UV- vis absorption studies of PTS with Arg & Lys revealed that the presence of acidic OH functional group in HPTS probe is essential for the detection of Arg & Lys.The limitof detection(LOD) was found to be 1.941 × 10−6M, whereas for Lys the LOD was 3.106 × 10−6 M, respectively. Interestingly, the probe also shows reversibility by addition of tetrabutylammonium phosphate (TBAP).

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 136 Exploring New Horizons in Chemical Sciences-2019

PP- 205

Studies of stability constants of 4-((3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4- yl)methyleneamino)-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol with Co(II), Ni(II), Mn(II) and Zn(II) ions Ashvini V. Sonone Department of Chemistry, Dr. Rafiq Zakaria College for Women, Navkhanda, Aurangabad.

*Corresponding author: [email protected]

Abstract: pH-metry is one of the most successful techniques used for measurement of simultaneous equilibrium of transition metals. Binary complexes of transition metal ions Co(II), Mn(II), Ni(II) and Zn(II) with 4- ((3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methyleneamino)-5-(pyridin-4-yl)-4H-1,2,4-triazole-3- thiol as a ligand studied by Calvin-Bjerrun titration technique modified by Irving and Rossotti. Stability constant were studied at 27±1. It observed that the transition metal ion forms the 1:1 complex with ligand.

PP- 206

Synthesis of coumarin derivative based fluorescent probe for detection of HOCl

Milind S. Thakare* a, Santosh S. Dipkeb, Pravin M. Yeolec a,bPratap College, Amalnerc, R. L College Parola *Corresponding author: [email protected]

Abstract: We herewith present a new reaction basedcoumarin derived fluorescent probe 7-(4 aminophenoxy)-4- methyl-2H-chromen-2-one which was designed and synthesized for detection of HOCl. On exposing the probe to HOCl showed marked increase in fluorescence intensity .The key aspects of the synthesized fluorescent probe were low detection limit, nice selectivity and great sensitivity which had been confirmed by UV-vis, fluorescence spectral study.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 137 Exploring New Horizons in Chemical Sciences-2019

PP-207

UV- Spectrophotometric simultaneous estimation: Method development and validation of Metoprolol succinate and Cilnidipine content in drug substances and drug products

Rajesh S. Jadhav, Milind B. Ubale and Jagdish V. Bharad*

Department of Chemistry, Vasantrao Naik Mahavidyalaya, Aurangabad-431003, (M.S) India.

*Corresponding author:[email protected]

Abstract: A simple, easy, rapid, specific, accurate and precise and accurate method has been developed and validated for simultaneous estimation of Metoprolol succinate and Cilnidipine. Metoprolol succinate showed the absorption maxima at 221 nm and Cilnidipine confirmed the absorption maxima in at 240 nm and found was linear for a range of 5µg/ml–25µg/ml with correlation coefficient of 0.9992 and 0.9997 respectively for Metoprolol succinate and Cilnidipine. The proposed analytical method- validation was performed by carrying out precision and accuracy studies. The Accuracy parameter was assessed by recovery studies and was found to be within range of percentage 98.1% to 101.5% respectively for Metoprolol succinate and Cilnidipine. The estimated analytical method established overall precision (Intra and Inter) with relative standard deviation 1.67% and 1.24% for Metoprolol succinate and Cilnidipine which is less than 2. The estimated analytical method was validated for the test parameter Specificity, Precision, Linearity and range, Ruggedness, Accuracy and recovery, hence developed analytical method for simultaneous estimation of Metoprolol succinate and Cilnidipine content in formulation drug and drug products by UV Spectrophotometric technique found simple, time saving, easy, accurate and precise, reasonable and can be applied for the day to day routine analysis purpose in Laboratory QC.

Keywords: λ-max, Validation, Metoprolol succinate, Cilnidipine, UV-Spectrophotometer. PP-208

Kinetic Study of Oxidation of Cyclic Alcohols by N-Bromosaccharin in Acetic Acid-Water Medium.

Sardarsingh Rajput, Jagdish Bharad, Milind Ubale and Jaishree Chamargore* Department of Chemistry, Vasantrao Naik Mahavidyalaya, Aurangabad. (M.S.) India.

*Corresponding author: [email protected]

Abstract: Kinetic investigations of oxidation of some cyclic alcohols (cyclopentanol, cyclohexanol and cycloheptanol) by N-Bromosaccharin (NBSA) in aqueous acetic acid medium have been studied. The reaction exhibits a first order rate dependence with respect to oxidant, while it is fractional order in + cyclic alcohols. The variation of ionic strength, Hg(OAC)2 , H have insignificant effect on reaction rate. Effect of varying dielectric constant of medium on the rate has been studied. Activation parameters have been evaluated from Arrhenius plot by studying the reaction at different temperature. The rate law has been derived on the basis of obtained data.

Keywords: Kinetics, Oxidation, Cyclic alcohols, N-Bromosaccharin.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 138 Exploring New Horizons in Chemical Sciences-2019

PP- 209 Reduction of p-Nitrophenol to p-Aminophenol by Using NiO Catalysts: A Comparative Study Radhakrishna S. Sutar, Rani P. Barkul, Meghshyam K. Patil* Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Sub- Campus Osmanabad- 413 501, Maharashtra, India.

*Corresponding author: [email protected]

Abstract: In the present study, different nickel oxide catalysts have been prepared by simple precipitation method using different nickel precursors and using surfactant sodium dodecyl sulfate (SDS)or without surfactant. The prepared catalysts have been characterized by using XRD and particle size have been calculated by using Scherrer equation. The nickel oxide catalyst prepared by using nickel acetate as precursor and surfactant SDS has shown less particle size as compare to other catalysts prepared by using other precursors. Also, nickel oxide catalyst prepared using nickel acetate precursor and surfactant SDS, has shown higher catalytic activity for reduction of p-nitrophenol (PNP) to p-aminophenol (PAP) using sodium borohydride (NaBH4). Also, reaction parameters such as concentration of p-nitrophenol and amount of NaBH4have been studied.

1.8

1.6 Catalyst: NiAC-SDS PNP PNP-NaBH 4 1.4 2 min 1.2 4 min 8 min 1.0

0.8

0.6 Absorbance (a. u.) (a. Absorbance 0.4

0.2

0.0

-0.2 200 300 400 500 600 Wavelength (nm) PP- 210

Facile Synthesis of Aromatic Substituted Nitriles in aq. Ethanol

Suresh U. Shisodia,1* Sudam S. Pandule,1 Pooja U. Pawar,2 Ravindra Janjal,2 1Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy. 2Department of Chemistry, Deogiri College, Aurangabad-431005, Maharashtra, India.

*Corresponding author: [email protected] Abstract: Aromatic substituted nitriles have gain importance as they are very useful starting materials for the synthesis of different biologically important heterocyclic compounds. The direct transformation of benzaldehydes into the corresponding aromatic nitriles is one of the most important reactions in organic transformations. Thus considerable efforts have been directed towards developing efficient methods for the conversion of aldehydes into corresponding nitriles. Among the numerous methods to prepare nitriles, the dehydration of aldoximes has been served as one of the most useful method.The high yield efficient synthesis of aromatic nitriles from substituted benzaldehydes and hydroxylamine hydrochloride, in aq. ethanol (66 %) as a solvent to give oxime which subsequently on dehydration in acetic anhydride gives nitriles in excellent yields, at low cost under mild reaction conditions are described here. This approach represents new “green” route and provides several advantages such as environmentally friendly, short reaction time (20-30 minutes), high yields and simple work-up procedure. International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 139 Exploring New Horizons in Chemical Sciences-2019

PP-211

One pot BF3.ACN complex catalyzed solvent free synthesis of 3, 4- dihydropyrimidine-2-one analogues.

1 1 1* A. A. Kharpe , T. S. Choudhare , S. N. Mokale, Prashant. D. Netankar 1Department of Chemistry, Maulana Azad College, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, India.

*Corresponding author: [email protected]

Abstract: One-pot solvent free three components coupling of aryl aldehydes,β-dicarbonyl compounds, urea and thio urea was performed to afford corresponding3,4-dihydropyrimidine-2-ones and their sulfur analogs 3,4-dihydro-pyrimidine-2-thiones. It is first report of BF3.ACN complex catalyzed solvent free synthesis of pyrimidone analogues.

Keywords: BF3.ACN complex, Solventfree, 3,4-Dihydropyrimidine-2-one;3,4-Dihydropyrimidine-2- thione

PP- 212 Synthesis and characterization of a novel schiff base metal complexes: An eco- friendly study

Sadashiv N. Sinkar1, Sunil R. Mirgane2, Rajedra P. Pawar3

1Department of Chemistry, Arts Science &Commerce College Ambad-431204(M.S.) India. 2Department of Chemistry, J.E.S. College Jalna -431203(M.S.) India. 3Department of Chemistry, Deogiri College Aurangabad -431001(M.S.) India.

*Corresponding author: [email protected] Abstract: A rapid, efficient, clean and environment benign exclusive synthesis of new Schiffbase ligand has been developed using condensation of 2-amino benzimidazole with syringaldehyde an excellent yields under microwaveirradiation. Schiff bases were used for complexation withMn(II),Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ag(I)ions. All the synthesized Schiff bases and their metal complexes were characterized by elemental analysis, UV, IR, 1H, NMR, MASS spectra, and TG-DTA analysis and powder X-ray diffraction method. Further the synthesized ligands and complexes were evaluated for antibacterial activity against four gram-negative and two gram-positive bacterial stains using agar-well diffusion method. Some Schiff bases and complexes were found to exhibit low to moderate activity. Different Schiff bases which were inactive before complexation; became active upon coordination with mentioned bivalent transition metal ions.

Keywords: Microwave irradiation, Schiff bases, 2-Amino Benzimidazole, Syringaldehyde, Biological activities.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 140 Exploring New Horizons in Chemical Sciences-2019

PP- 213 Effect of Deposition Temperature on Structural and Optical Properties of Chemically Sprayed Zinc Sulfide Thin Films

B. L. Shinde1 C. S. Patil2* 1Department of Chemistry, Arts, Commerce & Science College Sonai, Newasa, Dist. Ahmednagar. 2Department of Chemistry. Deogiri College Aurangabad.

*Corresponding author: [email protected]

Abstract: The II-VI group semiconductors are of great importance due to their applications in various optoelectronic devices. Among these semiconductors; zinc sulfide is the most suitable for its utility in optoelectronic devices. Zinc Sulfide has been prepared on glass substrate by using spray pyrolysis method. The effect of changing substrate temperature (200, 250, 300, 350 and 400 °C) on structure and optical properties is presented. The films have been characterized by X- ray diffraction (XRD), photoluminescence (PL) spectroscopy and field emission scanning electron microscopy (FESEM). Optical properties of these films have been studied in the wavelength range 380-1000-nm using UV- VIS spectro-photometer. All the deposited ZnS films show a cubic structure, while crystallinity and morphology are found which depend on spray temperature. PL analysis indicates the presence of violet and green emissions arising from Zn and S vacancies. The value of band gap of ZnS films is found to decrease slightly with increasing substrate temperature; changing in the range 3.52–3.25eV, most probably associated with the formation of Zn(S, O) solid solution.

Keywords: Zinc sulfide; Spray pyrolysis; Photoluminescence; Scanning electron microscopy; Defects

PP-214

FT-IR, Volumetric and Viscometric Studies of Interaction between Alkyl Formates and iso-butanol at Temperature 298.15, 303.15, 308.15 & 313.15 K.

Satishkumar D. Thakare, Mehdi Hasan, Vijaykumar M. Joshi #,

#K. R. A. Arts, Science and Commerce College, Deola, Pin- 423102.

*Corresponding author: [email protected]

Abstract: Densities and viscosities of binary mixtures of iso-butanol with ethyl formate, butyl formate and hexyl formate have been measured over the entire range of composition, at T= (298.15, 303.15, 308.15 and 313.15) K and at atmospheric pressure. The VE values are positive for all the binary mixtures studied over the entire composition range, while ∆η are negative for all the binary mixtures. These parameters have been fitted to Redlich-Kister polynomial equation. McAllister’s multibody model has been used to co-relate the kinematic viscosities of the binary mixtures. Neat FT-IR spectra are also taken.

Keywords: Excess molar volumes, Deviation in viscosity, FT-IR, Isobutanol, Ethyl formate, Butyl formate, Hexyl formate.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 141 Exploring New Horizons in Chemical Sciences-2019

PP- 215

Synthesis of Schiff’s Bases from 2-Amino-4H-1, 3 - Oxazine/Thiazine and Substituted Aldehydes and their transition metal complexes

* D.T. Biradar, M. B. Swami, D. B. Muley Department of Chemistry, Research Centre, Shivaji Mahavidyalaya, Udgir Dist. Latur (M.S.) Department of Chemistry, Bahirji Smarak Mahavidyalaya, Basmat

*Corresponding author: [email protected], [email protected]

Abstract: One pot multi-component synthesis of Schiff’s base as new ligand an their complexes with Ni, Fe, Co and Cu and developed using 2-amino-4H-1,3 xazines/thiazines and substituted Aldehydes, different catalyst are used to synthesize of 2-amino 4H-1,3 oxazines. Its characterization is confirmed by taking IR, NMR spectra. The Schiff’s base act as ligand, is bidentate when it is treated to metal complexes in 1:1 ratio (metal: ligand) complexes are formed.

Keywords: Schiff’s bases, 2-Amine-4H-11, 3 oxazines, Aldehydes, Coordination complexes

Ar O Ar X H O, C 2 120-250 N M-WR, 30 min. Ar H CH H2N H2N Ar X NH2

PP- 216

Facile, Rapid and One Pot Synthesis of Pyrano[2,3-c]Pyrazole in Aqueous Medium

A. P. Katariya, S. U. Deshmukh, M. V. Katariya*, R. P. Pawar*

Department of Chemistry, Deogiri College, Station Road, Aurangabad 431 005, MS, India.

*Corresponding author: [email protected], [email protected]

Abstract: An efficient synthesis of Pyrano[2,3-c]Pyrazole derivatives by four component one pot condensation of hydrazine hydrate, ethyl acetoacetate, aldehyde and malononitrile catalyzed by potassium tertiary butoxide in aqueous medium is described. This method follows the principles of green chemistry and being an environment friendly method for synthesis of Pyrano[2,3-c]Pyrazole.

Keywords: Pyrano[2,3-c]pyrazole,Green chemistry, Aqueous medium, Environment friendly.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 142 Exploring New Horizons in Chemical Sciences-2019

PP- 217

Phytochemical and physicochemical properties of conventional extraction and microwave assisted extraction of Cestrum necturm Leaves

Samreen Fatema1, Mohd Imran Anees2, Mazahar Farooqui3, and Pathan Mohd Arif*1 1Post graduate and research center, Maulana Azad College, Aurangabad (MS), India 431001. 2Y.B Chavan College of Pharmacy, Aurangabad (MS) India 431001. 3Dr. Rafiq Zakaria College for women, Navkhanda, Aurangabad (MS) India 431001. *Corresponding author: [email protected]

Abstract: Cestrum nocturnumLinn. belongs to solanaceae. It is commonly known as Raat rani, lady of night or night Jessamine have great medicinal value. The plant was extracted using conventional extraction as well as microwave assisted extraction. The phytochemicals such as carbohydrate, proteins, amino acid, glycoside, phenolic compounds and tannins has been qualitatively determined. The physicochemical properties such as relative density, viscosity, surface tension and refractive index were determined. All properties of microwave assisted extract were found to be more than aqueous extract. UV-Vis and IR data was compared. The extract was screened for biological activity and aqueous extract is found to be active against E. coli, B. Subtillis, S. Typhi, S. Aureus, Tuberculosis, and Malaria.

PP- 218

Synthesis, Spectral and Antibacterial Studies of Some Transition Metal Complexes Derived From Schiff Base Ligand

S. A. Survase1, C. S. Patil2, M. A. Sakhare1, Y. N. Bharate1 1Department of Chemistry, Balbhim College, Beed. (MH) 2Department of Chemistry, Deogiri College, Aurangabad. (MH) *Corresponding author: [email protected], [email protected]

Abstract: Schiff base complexes have remained an important and popular area of research due to their simple synthesis, versatility and diverse range of applications. Metal complexes of Schiff base ligands possess a variety of applications in the biological, analytical, clinical and industrial areas. In recent times, transition metal complexes of Schiff base ligands have gained considerable attention, not only due to their spectroscopic properties and applications but also due to their remarkable antifungal, antibacterial and antitumor activities. Due to presence of the imine group, the electron cloud of the aromatic ring and electro negative nitrogen, oxygen and sulphur atoms are in the Schiff’s base molecules, these compound effectively prevent corrosion of mild steel, copper, Aluminum, zinc in acidic medium. Transition metal complexes with salen ligands are used in catalytic reactions. Such salen complexes are used to catalyze the peroxidation reaction of olefins. For example, Mn2+ salen complex has been used for chiral peroxidation. In view of these facts, reaction of the transition metal salts and Schiff bas ligands has been carried out and structure of the resulting complex was investigated using spectroscopic techniques and Thermal analysis. Considering the importance of metal ligand complexes of transition metal. We have prepared N-N bis (salicylidene)ethylene-1,2-diamine (salen) Ligand derived from the 2:1 molar condensation of Salicyladehyde and ethylenediamine by simple stirring method and characterized by elemental analysis, FT-IR, 1H NMR analysis. The transition metal complexes of salen have been characterized by UV- visible FT-IR, TGA-DTA.Ligand and their transition metal complexes were screened for antibacterial activity against Escherichia coli, pseudomonas aerugenosa and Bacillus spp.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 143 Exploring New Horizons in Chemical Sciences-2019

PP- 219 Dithiafulvenyl-Naphthalenediimide-Based Electron- Transport Layer for Inverted Perovskite Solar Cells

Dada B. Shaikh,1 Avinash L. Puyad,2 Sheshanath V. Bhosale,3 Sidhanath V. Bhosale1* 1Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, Telangana, India and Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India. 2School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded-436106, Maharashtra, India 3Department of Chemistry, Goa University, Taleigao Plateau, Goa-403206, India.

*Corresponding author: [email protected]; [email protected]

Abstract: The present work is concerned with the synthesis of novel derivative of naphthalenediimide core substituted dithiafulvenyl (DTF) DS1 and DS2 as a perovskite material, to replace expensive PCBM in inverted perovskite solar cells (PSCs). These two chemical entities were synthesized and characterized by advanced analytical tools for apply to electron transport layer (ETL) to make inverted PSCs based on CH3NH3PbI3-xClx. These two molecules showing good power conversion efficiencies (PCEs) of inverted PSCs based on DS1 and DS2 exhibit 9.6 % and 11.4%, respectively. The rising of PCE values in DS2 compared to DS1 because of two DTF units are present on NDI core and one DTF unit present on NDI core. The result showing that the NDI based small entity can apply as a hopeful ETL in inverted PSCs to obtain high efficiency.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 144 Exploring New Horizons in Chemical Sciences-2019

PP-220 Supramolecular Self-Assembly of Water Soluble Aie-Active Sulphonated Tetraphenylethylene (Su-Tpe) With Spermine.

Jotiram N. Malegaonkara, Sheshanath V. Bhosale, Sidhanath V. Bhosale*a a Polymer and Functional Material Division, CSIR-Indian Institute of Chemical Technology, ( CSIR- IICT), Hyderabad-500607 Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.

*Corresponding author: [email protected], [email protected]

Abstract: The Su-TPE is non-emissive in aqueous solution and strongly luminescent upon the addition of an Organic Solvent such as THF (fTHF = 95%) which is opposite phenomenon with traditional AIE active molecules. Here we demonstrate the effect of spermine with different equivalents on morphologies of supramolecular structures. Nanobelts, nanosheets, globular and nanotubular structures indicating possible self assembly of Su-TPE with Spermine. The Self aggregation of Su-TPE with different equivalent of Su-TPE at various pH was confirmed by using UV-Vis absorption, Fluorescence emission spectroscopy, FT-IR, DLS, SEM and XRD technique.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 145 Exploring New Horizons in Chemical Sciences-2019

PP- 221 Phytochemical Screening of Methanolic extract of Tulsi (Ocimum santum L.)

D. J. Jain, S. K. Rajurkar

Department of Botany, Deogiri Collage, Aurangabad (M.S) *Corresponding author: [email protected]

Abstract: Ocimum santumL.is serves as medicine in Indian medicinal system in ancient time and today’s .This plant is potential source of bioactive molecules. In recent years, the indigenous systemof medicineare getting more importance because of therapeutic value of these medicinal plants. In present study primary biochemical analysis followed by HRLCMS analysis leads to the identification of 98 secondary metabolite. In which Triparanol has cholesterol lowering effect. Quercitrin is antioxidant and antileshmanial agent. Khivorinis is an aromatic compound. Nivalenol is important glucoside. Ketotifenuseful in eyes disorderand Tuberonic acid and Ecgonine are various chemical compounds getting eluted from chemical profile of methanol extract of Tulsi leaf.

PP-222 One Pot Green Synthesis of Bioactive Pyranopyrazoles a a b c a* Hanuman D. Bhosale , Suresh U. Shisodia , Rajita D. Ingle , Shivaji B. Munde , Rajendra P. Pawar aDepartment of Chemistry, Deogiri College, Station Road, Aurangabad-431005 (MS) India. bDepartment of Chemistry, R. B. Attal Arts, Science & Commerce College, Georai, Beed, Maharashtra, India. cDepartment of Chemistry, Shri Muktanand College, Gangapur (MS)-431 109 India.

*Corresponding author: [email protected], [email protected] Abstract: Pyrano pyrazoles are fused heterocyclic compounds; they are having wide range of biological activities. The fused ring system adds functional diversity to the molecule and provides fruitful area to study the bioactivity. Pyranopyrazole scaffold has shown bioactivity such as anticoagulant, spasmolytic, hypnotic, diuretic,1 insecticidal,2 anti-inflammatory,3 anticancer,4 antibacterial and antifungal5, as well as antimicrobial.6 Being bioactive molecule, scientists have developed several methodologies for the synthesis of pyranopyrazoles by using different catalysts. In continuation of our efforts for the development of ecofriendly synthetic methodologies towards the synthesis of bioactive heterocyclic compounds, herein we wish to report one pot four component synthesis of pyranopyrazoles by the reaction of aromatic aldehyde, malononitrile, ethyl acetoacetate, hydrazine hydrate using pipyridine as a catalyst in aqueous medium under ultrasound irradiation method in short time.

O O O CN H CN Water + + NH2NH2.H2O + N CN O Ultrasonication N O NH H 2

Scheme: Synthesis of pyrano-pyrazole

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 146 Exploring New Horizons in Chemical Sciences-2019

PP- 223 Different Shodhana Procedures and HPLC analysis of Kupilu

Dr. Megha R. Survase1*, Dr. Aparna S. Taware2 and Manisha R. Survase3

1Assistant Professor, Department of Panchakarma, CSMSS Ayurveda Mahavidyalaya, Aurangabad. 2Assistant Professor, Department of Botany, Deogiri College, Aurangabad. 3Research Scholar, Institute of Biosciences and Technology, MGM, Aurangabad

*Corresponding author: [email protected] Abstract: Kupilu is the ayurvedic drug, which though toxic in nature, can be used for therapeutic purpose, after proper processing. In Ayurveda different types of shodhana procedures are mentioned to reduce the toxicity of drug, so that it can be used safely for medicinal purpose. Present study was carried out to know effect of different shodhana procedures on the chemical constituents of kupilu. Five different shodhana procedures are used and HPLC analyses were done. The media selected for Shodhana were cow’s milk, cows dung, cow’s urine, cow’s ghee and kanji. All the shodhana procedures brought about significant changes in Strychnine and Brucine. Significant reduction of Strychnine and Brucine were observed in cow milk shodhana sample.

PP-224 Targeting and tuning nucleic acid structures for therapeutic and biotechnology applications Ambadas B. Rode Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad - 121 001, Haryana (NCR Delhi), India. Corresponding author: [email protected] Abstract: Our group uses synthetic organic chemistry, molecular biology and biophysical chemistry techniques to get insights into the nucleic acids structure-function relationship in human and bacteria. Next, we apply this obtained knowledge to develop synthetic molecules to target the nucleic acid structures for therapy or to create synthetic nucleic acids tools to solve problems in biotechnology.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 147 Exploring New Horizons in Chemical Sciences-2019

PP-225 Copper silicate catalyzed efficient synthesis of 2, 4, 5 trisubstituted Imidazole derivatives. Ajit K. Dhasa, Satish U. Deshmukha, Amol J. Shirsatb, Rajendra P. Pawara, Gopal K. Kakadec*.

aDepartment of Chemistry, Deogiri College, Aurangabad, (MS), India. bDepartment of Chemistry R. B. Attal College, Georai, Dist.-Beed (MS)India cDepartment of Chemistry, Arts, Commerce & Science College, Kille Dharur, Dist.-Beed (MS)India. **Corresponding author: [email protected]

Abstract: An efficient method for the synthesis of 2, 4, 5 trisubstituted Imidazole derivatives has been developed by using substituted aldehydes, benzil and ammonium acetate in ethanol and copper silicates as catalyst. This synthetic protocol has some advantages such as short reaction time, high yield, reusable catalyst and easy workup procedure.

Keywords: Substituted aldehydes, benzil, ammonium acetate, copper silicate.

CHO R R O 1 2 R5 R1 N Ammonium acetate, Copper-Silicate R3 N O R4 R2 Ethanol, Reflux H R5 R4 R3

Scheme: Synthesis of substituted 2, 4, 5 trisubstituted imidazole derivatives. PP-226 One-pot synthesis of 4,4-(aryl methane)bis(3-methyl-1H-pyrazol-5-ol)s using ionic liquids Satish U. Deshmukha, Ram D. Isankarb, Om B. Pawarc, Rajendra P. Pawara* aDepartment of Chemistry, Deogiri College, Aurangabad, 431005 (MS), India. bGovernment Vidharbha Institute of Science and Humanities Amravati (MS) India. cRajaram college, Kolhapur (MS) India. *Corresponding author: [email protected] Abstract: One-pot synthesis of 4,4-(arylmethane)bis(3-methyl-1H-pyrazol-5-ol)s has been developed using substituted aldehydes and 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one in ethanol and ionic liquids as catalyst. The synthetic method has several advantages such as high yields, reusable catalyst and easy workup procedure.

Keywords: Ionic liquids, 4,4-(arylmethane)bis(3-methyl-1H-pyrazol-5-ol)s, aldehydes and 3-methyl- 1-phenyl-1H-pyrazol-5(4H)-one.

R1

CHO N Ionic liquids N O N 2 N Ethanol N N Reflux HO HO R1

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PP-227 Microwave-assisted synthesis of some new bis-1, 3-benzoxazines and their antimicrobial activity

Avinash T. Shindea*, Nagesh J. Deshmukha, Sainath B. Zangadeb

aDepartment of Chemistry, N. E. S.Science College, Nanded (MS), India-431605 bDepartment of Chemistry, M. P. College, Palam, Parbhani (MS), India-431720.

*Corresponding author: [email protected]

Abstract: Benzoxazines based heterocyclic compounds forms an important class of benzfused heterocycles with wide spectrum of biological activity. In the present work, the series of bis-1, 3-benzoxazines were synthesized from reduced product of propane-1, 3-diamine Schiff bases in the presence of formalin under conventional heating and microwave irradiation. The structures of newly synthesized diamines and bis-1, 3-benzoxazines were established on the basis of spectroscopic data. Further, all the synthesized compounds were screened for antimicrobial activity. Some of the compounds showed very good activity compared to standard drugs against all pathogenic bacteria and fungi.

PP-228 Microwave assisted synthesis of 2-azetidinone derivatives as promising antimicrobial analogs

Sainath Zangade1, Avinash Shinde2, Yogesh Nalwar3 and Pravinkumar Patil2 1 U. G. Department of Studies in Chemistry, Madhavrao Patil ACS College, Palam, Dist. Parbhani-431720 (M S) India. 2 Department of Chemistry, N.E.S. Science College, Nanded (MS) India-431605. 3 Department of Chemistry, Toshniwal ACS College, Sengaon, Dist. Hingoli (M S) India- 431542. Corresponding author: [email protected] Abstract: Several substituted 4‐azetidinone derivatives ii have been synthesized from halogenohydroxy substituted Schiff bases i under microwave irradiation technique. The reactions were carried out using ethanol: 2-methoxyethanol mixture as efficient reaction solvent system to afford high yield of product. The structures of newly synthesized compounds have been established on the basis of elemental analysis, IR, 1H & 13C NMR and mass spectral data. Further, all newly synthesized compounds were screened for their in vitro antimicrobial activity. The antifungal and antibacterial effects of the tested compounds are due to their molecular structure and substituent present. Ar'

MWI N EtOH: 2-methoxyethanol Ar Ar-C=N Ar' Chloroacetyl chloride o (0.002 mmol) H3C CH3 i ii Cl

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PP-229 Resin-immobilized palladium nanoparticle catalysts for Suzuki coupling reaction in aqueous media Satish B. Manjarea, Shankar R. Thopateb, Rajendra A. Chaudharic* aDepartment of Chemistry, Rizvi College of Arts,Commerce and Science, Bandra (W), Mumbai 400050. M.S. India. bProf. John Barnabas school for biological studies, Department of Chemistry, Ahmednagar College, Ahmednagar, Station Road, Ahmednagar 414001. M.S. India. cDepartment of Chemistry, Rizvi College of Arts,Commerce and Science, Bandra (W), Mumbai 400050. M.S. India.

*Corresponding author: [email protected] Abstract: Macroporous ion-exchange resins were used to immobilize palladium (Pd) metal in order to produce nanoparticle catalysts. The complexation of palladium acetate and following reduction with sodium borohydride to Pd nanoparticles carried out by two macroporous ion exchange resins. Palladium loading was quantified by inductively coupled plasma-mass spectrometry (ICP-MS), Field emission scanning electron microscope/energy-dispersive X-ray spectrometry (FE-SEM/EDX). Palldium nanoparticles immobilized on a macroporous resins exhibited excellent catalytic activity for Suzuki coupling reaction. Furthermore, the catalyst can be recycled without significant loss of its catalytic activity.

Keywords: Palladium nanoparticles (PdNP), Ion-exchange resin, Green synthesis, Suzuki coupling

PP-230 Green Tea Coated Nanocellulose for Multifunctional Applications Farsa Ram, 1, 2 Sithara R.3 and Kadhiravan Shanmuganathan*1,2 1Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, 3) Dr. Homibhabha Road, Pune, Maharashtra-411008, India 2 Academy of Scientific and innovative Research,CSIR-National Chemical Laboratory, 4) Dr. Homibhabha Road, Pune, Maharashtra-411008, India 3Department of Polymer Science and Rubber Technology, Cochin University of Science and Technology, Kochi, Kerala 682022. *Corresponding author: [email protected] Abstract: Camellia Sinensis commonly known as tea is a widely consumed beverage in the Indian subcontinent, which is a rich source of dietary polyphenols. Polyphenols are traditionally used as dyes, in the coating, nanoparticle synthesis, and surfactants, etc. The polyphenols act as an antioxidant, metal chelators, antimicrobial agents and radical scavengers. The steamed or pan-fired tea leaves are known as green tea. The green tea extract has epigallocatechin-3-gallate in the higher amount which is responsible for antioxidant properties of the green tea. The green tea extract can coat on various surfaces due to the higher concentrations of polyphenols. We took advantage of its coating nature and brewed the green tea along with renewable polymer nanocellulose. The obtained green tea coated nanocellulose (GT@NC) was used for cationic dye adsorption and scavenging of radicals. Methylene blue (MB) which is organic effluent from textile industries could be adsorbed by GT@NC. The GT@NC could remove the MB up to 60-85% with varying the concentration of MB from 16 mg/L to 2 mg/L. The kinetics of dye adsorption studied using pseudo first order, pseudo-second order, Langmuir and Freundlich adsorption isotherm. The GT@NC also showed a significant reduction in the concentration of 2, 2-diphenyl-1- picrylhydrazyl (DPPH) radicals.

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PP-231 Synthesis of new aggregation-induced-emission (AIE)-active luminophores for supramolecular self-assembly Vishal G. More, Mahesh D. Burud, and Sheshanath V. Bhosale* Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206, India. *Corresponding author: [email protected]

Abstract: Aggregation Induced emission luminogens (AIEgens) have attracted great attention of the researcher due to their applications in materials and biotechnology such as organic light-emitting diodes, sensors, multistimuli-responsive materials etc.Various AIEgens with excellent luminescence properties in the solid state have been developed, which includes hexaphenylsilole (HPS). 1,1-Dimethyl-2,3,4,5- tetraphenylsilole (DMTPS), tetraphenylethene (TPE), tetraphenylpyrazine (TPP), tetraphenyl-1,4- butadiene (TPBD) etc.1,2 Nevertheless, some suffer from intrinsic drawbacks for examples TPE and TPBD contains double bonds which usually give rise to E/Z isomerisation.Thus, there was a need to develop AIEgens with good stability and excellent luminescence properties. In 2013, Gryko reported for the first time synthesis of Tetraaryl-1,4-dihydropyrrolo[3,2-b]pyrroles (TAPP) and their derivatives.3 However, failed to improve yield of TAPP even by changing the solvents, adding mild oxidants (dimethyl sulfoxide, DDQ, DMSO, Ce(NH4)2(NO3)6, and nitrobenzene), even chaining order of reagent addition and prolonging the reaction time did not change the % yield of the compounds. However, given the importance of the ring structure, further improvement required to high the yield protocol. Herein, we report the synthesis of TAPP by cyclocondensastion ofaromatic amine, aromatic aldehyde and 2, 3-butanedione with 10 mol% catalyst. This three components reaction is carried out in acetonitrile at 90 oC for 3h, a fluorescent yellow crystalline product started to precipitate from the reaction mixture (Scheme 1). This protocol offers four main advantageous: i) improved yield to 75%, ii) simple work-up, iii) after completion of the reaction solvent acetonitrile can distil and reuse, and iv) pyrrolopyroles can be prepared in gram quantities by simple filtration.

PP-232 Synthesis and antimicrobial activity of some novel 2-(substituted styrene)benzo[d]oxazol derivatives a a b a a R. A. Shastri* , P. P. Joshi , S. B. Jadhav , D. D. Kayande , A. M. Dodkey aP.G. Department of Chemistry S.B.E.S. College of Science, Aurangabad 431001, Maharashtra, India, bBalbhim Arts, Science and Commerce College, Beed-431122, Maharashtra, India. *Corresponding author: [email protected] Abstrcat: Some novel 2-(substituted styrene)benzo[d]oxazol(3a-h) have been synthesized starting fromsubstituted cinnamic acid (1a-h) with o-aminophenol (2) in the presence of POCl3. The advantages of this method are excellent yields, short reaction time, no-side reaction, operational simplicity and ease in experimental procedure. Their structures have been established on the basis of spectral data, and evaluated for antimicrobial activity by disc diffusion method and poisoned plate method. Compounds (3a-h) exhibit good antibacterial activity and antifungal activity.

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PP-233 Controlled supramolecular helical assembly from achiral molecule triggered by solvent Dinesh N. Nadimetla, Mahesh D. Burud and Sheshanath V. Bhosale* Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206, India. *Corresponding author: [email protected] Abstract: The rational design of chemical entities which are able to self-assemble into stable and dynamically ordered chiral/helical superstructures is essential if supramolecular materials are to be implemented in applications such as biomedicine, catalysis, optoelectronics and materials chemistry. Furthermore, stimuli-triggered self-assembly plays an important role in the control of structural transformations in supramolecular living entities on the molecular, cellular, and macroscopic domains. Several parameters drive supramolecular self-assembly of synthetic molecules, including the nature of the solvent, temperature, and molecular design to control electronic and functional properties. To achieve controlled supramolecular structures, diverse molecular non-covalent interactions have been used, including hydrogen bonding, hydrophobic, van der Waals, ionic and electrostatic interactions, solvophobic effects, and π-π stacking between adjacent aromatic planes. Among the aggregation-induced-emission (AIE)-active luminophores developed so far, tetraphenylethene (TPE) derivatives have attracted significant attention due to their weak intermolecular interactions and excellent solubility in organic solvents, with a structure that is susceptible to functionalization on the planar phenyl groups, which may lead to AIE activity. In this work, we described in detail the synthesis, properties and applications of novel TPE-derivatives and their supramolecular self-assembly. Importantly, we present work we demonstrate the induction of chirality in supramolecular self-assembled nanostructure made from AIE-active achiral molecules.Various technique used to characterise the formation of helical structure for example solution dependent assembly was characterised by circular dichrosium, UV-vis absorption and fluorescence spectroscopy. Finally Scanning Electron Microscopy (see image) used to visualises nature of helicity in the solid/aggregated states.

PP-234 Synthesis of multicomponent reaction for the preparation of dihydro pyrimidinones and thiones by using pivalic acid as a catalyst Rahul B. Shinde,a Dattatraya N. Pansare, b Mukund N. Bangal,a Ashok M. Zine*c aVinayakrao Patil Mahavidyalay Vaijapur, Aurangabad 423701, MS, India bDepartment of Chemistry, Deogiri college, Station road, Aurangabad 431 005, MS, India. cSundarrao Solanke Mahavidyalaya Majalgaon, Beed, 411 131, MS, India. *Corresponding author: [email protected] Abstract: One pot three components Biginelli reaction substituted aldehydes, urea, thiourea and β-dicarbonyl compound by using pivalic acid as a catalyst. In conventional methods, our protocol is convenient and offers advantages, such as shorter reaction time, higher yields.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 152 Exploring New Horizons in Chemical Sciences-2019

PP-235 Hybrid Nanoflowers from a kanamycin antibiotics and inorganic cations Template by a Hierarchical Supramolecular Scaffold

Ratan W. Jadhav, Asha D. Jangale and Sheshanath V. Bhosale* Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206, India. *Corresponding author: [email protected]

Abstract: The rational design of chemical entities which are able to self-assemble into stable and dynamically ordered superstructures is essential if supramolecular materials are to be implemented in applications such as biomedicine, catalysis, optoelectronics and materials chemistry. Furthermore, stimuli-triggered self-assembly plays an important role in the control of structural transformations in supramolecular living entities on the molecular, cellular, and macroscopic domains.To achieve controlled supramolecular structures, diverse molecular non-covalent interactions have been used, including hydrogen bonding, hydrophobic, van der Waals, ionic and electrostatic interactions, solvophobic effects, and π-π stacking between adjacent aromatic planes. Nevertheless, functional supramoleculare structures by self-assembly between inorganic salts and organic molecules have attracted much attention in recent years. A various method is reported for fabricating hybrid organic–inorganic nanoflowers using copper (II) ions as the inorganic component and natural amino acids as the organic component. However, utilising aminoglycosides flower-like structures are never been studied given that aminoglycosides antibiotics are very important molecule in everyday life. Herein, we report the design, synthesis and the self-assembly of inorganic cations and kanamycin in PBS buffer at environmental pH. It can be clearly seen that cations and kanamycin assembled into beautiful flower superstructure. ScanningElectron Microscopy (see image) clearly shows growth of flower and x-ray diffraction showing crystalline nature of flowers. The results clearly indicate that the interactions between copper ions with kanamycin cause the growth of the flowers via C, N, cation, and O elements. The flowers have porous structure and high surface-to-volume ratios, which may be beneficial for applying its peroxidase-like activity or water pollutant dyes.

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PP-236 Synthesis, characterization and anticancer activity of novel hydrazone C. B. Khillarea*, Shaikh Kabeer Ahmeda

a*P G Department of Chemistry, Maulana Azad College of Arts, Science and Commerce, Aurangabad, India aP G Department of Chemistry, Sir Sayyed College of Arts, Science and Commerce, Aurangabad, India. *Corresponding author: [email protected] Abstract: In the present study, novel Ligands of (E)-4-(((5Hcyclopenta[1,2-b:5,4-b’]dipyridin 5ylidene)hydrazono)methyl)-2,6-diiodophenol, (E)-4-(((5H-cyclopenta[1,2-b:5,4-0b’]dipyridin-5 ylidene)hydrazono)methyl)-2-bromo-6-methoxyphenol are synthesized and characterized by 1H NMR, 13C NMR, MASS, UV, IR, elemental analysis, and their in vitro anticancer activity is also tested. 4,5-diazafluoeren-9-one was synthesized using 1, 10-Phenanthroline hydrate, potassium hydroxide,potassium permanganate according to the previously reported method1.then the 4,5- diazafluoren-9-hydrazone was synthesized by refluxing 4,5-diazafluoeren-9-one with hydrazine hydrate in presence of acetic acid for 3h .Then a mixture of 4,5-diazafluoren-9-hydrazone and aldehyde was refluxed for 18 h in presence of acetic acid to produce the novel ligand.

Keywords: Hydrazone, 1, 10-phenanthroline

N N N KMnO NH2 4 15ml MeOH O + NH2NH2H2O N reflux reflux 3h N 1.5 h N N

4,5-diazafluoeren-9-one 4,5-diazafluoeren-9-hydrazone 1,10 phenanthroline + R R R R CHO N MeOH N R Acetic acid R R C reflux18h N H R N R R

PP-237 A review on biological activities of schiff base and their metal complexes.

P. M. Jadhav Department of Chemistry, Shri Muktanand College, Gangapur (MS), India.

*Corresponding author: [email protected] Abstract: Schiff bases and their metal complexes are wide range of biological applications and are synthesized from the condensation reaction of amino compounds with carbonyl compounds. Schiff base and their metal complexes have a wide variety of applications in food and dye industry, agrochemical, polymer, catalysis, analytical chemistry, antifertility, anti-inflammatory activity, antiradical activity, and biological system as enzymatic agents. Several have reviewed them of their antimicrobial, antibacterial, antifungal, antitumor, and cytotoxic activities. This review summarized the most promising biological activities of Schiff bases and their metal complexes.

Keywords: Schiff bases, metal complexes, biological activity. International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 154 Exploring New Horizons in Chemical Sciences-2019

PP-238 Assessment of sustainable Self Compacting Concrete with Nano particles at early stages Patil Hiteshkumar a, Arunkumar Dwivedi b, Aniruddha Chatterjee c a, Research Scholar, North Maharashtra University,Jalgaon-4225001(MS) India b Professor & Dean (Academics), Sandip University Trimbak Road Nashik-422213 (MS) India, 422213. c, Assistant Professor & Head, Plastics and Polymer Engineering Department, MIT, Aurangabad, Maharashtra- 431010(MS) India

*Corresponding author: [email protected], [email protected]

Abstract: In this exploration work the rheological properties of Self Compacting Concrete (SCC) with expansion of Nano composite materials are investigate. The Zinc Ash (ZA) and Blasting Grit (BG) are squander results of paint industry and accessible effortlessly. According to the exploration the ZA and BG are fused by weight of cement and fine aggregate in extent of 0 to 0.75%. Amid this exploration it was discovered that all usefulness properties as passing capacity, filling capacity, protection from isolation were increments when contrasted with typical SCC. The outcomes demonstrate that the all working capacity properties are increment when the level of expansion of material up to 0.5% and result increments up to 23% than ordinary Self Compacting Concrete, after 0.5% increase of ZA & BG the workability properties of SCC were diminishes. The consequence of Nano Composite SCC is on preferable side over Normal SCC because of increment, in particular gravity of SCC. The expansion of Nano Composite is constrained to 0.5% just, past this the solid turned out to be weak, and it required more W/C with the goal that the nature of SCC will be decreased. The cement utilized according to the blend configuration arranged is not as much as those of typical blend plan of SCC accessible in market. Subsequently Nano SCC is more prudent than typical SCC. The separation of ingredients additionally decreases up to extensive level with enhancement of functionality properties.

PP-239 Synthesis of pyrano[2,3-d]pyrimidone derivatives

Vijay P. Pagorea, Priti N. Bajadb, Sunil U. Tekalec, Rajendra P. Paward* aDepartment of Chemistry, Shri Muktanand College, Gangapur (MS)-431 109 India. bDepartment of Zoology, Shri Muktanand College, Gangapur (MS)- 431 109 India. caDepartment of Chemistry, Deogiri college, Aurangabad (MS)- 431 005 India.

*Corresponding author:[email protected]

Absrtact: A simple and efficient one-pot synthesis of pyrano[2,3-d]pyrimidine derivatives has been developed via three component condensation of aldehyde, malononitrile andbarbituric acid. An ionic liquid [EMIM] OH is used as catalyst methanol under microwave irradiations. Method offers simple, clean and rapid path for environmental benign synthesis of pyrano[2,3-d]pyrimidine derivatives.

R CHO X O CN CN HN NH [EMIM]OH HN R CN mw O O X N O NH2 H

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 155 Exploring New Horizons in Chemical Sciences-2019

PP-240 Organobase catalyzed one-pot four-component synthesis of multifunctionalized dihydropyridines

S. S. Kauthalea, S. U. Tekalea, V. P. Pagoreb, K. G. Hugec, A. M. Dodkeyd, R. P. Pawara*

aDepartment of Chemistry, Deogiri college, Aurangabad (MS)- 431 005 India. bDepartment of Chemistry, Shri Muktanand College, Gangapur (MS)-431 109 India. cK.K.M. College, Manwath. Dist. Parbhani, Maharashtra, India-431505. dDepartment of Chemistry S.B.E.S. College of Science, Aurangabad 431001, Maharashtra, India,

*Corresponding author: [email protected] Abstract: An atom efficient synthesis of polysubstituted dihydropyridine derivatives was successfully accomplished by the one-pot four-component condensation of aldehyde, amine, dialkyl acetylene dicarboxylate and active methylene compound such as malononitrile or ethyl cyanoacetate using morpholine as a catalyst at ambient temperature. Use organobase as a simple catalyst, room temperature conditions render the method protocol significant for the existing methods for the synthesis of multifunctionalized dihydropyridines.

PP-241

Green protocol for the Synthesis of 1, 5-Benzothiazepine Derivatives

Asgar Jafar Khana, S A Peerzadea and Mohammed A Baseerb a Laboratory of Organic Synthesis, Milliya College, Beed, (M.S), India b Organic Chemistry Research Laboratory, Yeshwant Mahavidayalaya, Nanded, India

*Corresponding Author: [email protected] Abstract: Heterocyclic compounds containing nitrogen and sulphur such as benzothiazepines have received considerable attention in recent years. Due to remarkable chemotherapeutic and pharmacological properties Benzothiazepine derivatives are nowadays utilized in drug research. Their derivatives are widely used as analgesic, sedative, antidepressive, and hypnotic, antiulcer, antifeedant, anticonvulsant, antianxiety, maintenance of Ca++ ion concentration and antimicrobial agents. Keeping in view their important utility, several procedures of synthesis are introduced in the literature. Their synthesis can be conveniently performed by condensation of α, β –unsaturated ketones with 2 aminothiophenol, for this condensation many reagents have been reported. Some of reported methods have several disadvantages and above all they are not eco-friendly. In this communication a green protocol for the synthesis of biologically active Benzothiazepine derivatives through novel catalyst under mild condition is reported.

Keywords: 1, 5-benzothiazepines, 2-aminothiophenol, Aromatic aldehydes, 1, 3-dicarbonyl compounds.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 156 Exploring New Horizons in Chemical Sciences-2019

PP-242 Microwave Assisted Synthesis of Hydroxy Chalcones and Their In-Vitro Antioxidant and Cytotoxic Activity G. D. Kottapallea, N. J. Deshmukha, B. T. Vhanalea, A. T. Shinde*a a. P.G. Department of Chemistry, N.E.S. Science College, Nanded (MS) -431602. *Corresponding author: [email protected] Abstract: New hydroxyl chalcones (1a-1e) have been synthesized by Claisen Schmidt condensation of aromatic hydroxy ketone and substituted aromatic aldehyde through microwave irradiation methods. The structures of synthesized compounds were established by spectroscopic technique. Further all compounds screened for invitro antioxidant and cytotoxic activity. Most of the compounds show potent activity.

Keywords: Aromatic hydroxyl ketone, Substituted aromatic aldehyde, microwave irradiation, antioxidant activity, cytotoxic activity.

PP-243 Silica-Suported perchloric Acid: A Efficient and Recyclable Catalyst for Benzimidazolo-[2, 3-b] quinazolinones Synthesis

Vinod V. Throat1, Maya V. Katariya1, R. D. Ingle1 Samson Mashele2, P. S. Kendrekar*2 and Rajendra P. Pawar*1, 1Department of Chemistry, Deogiri College, Aurangabad-431005, MS, India. 2Departmental Health Science, Central University of Technology, Free State, South Africa.

*Corresponding author: [email protected], [email protected] Abstract: Synthesis of benzimidazolo-quinazolinone derivatives in excellent yields by using silica supported perchoric acid (HClO4-SiO2) as a mild and reusable heterogeneous catalyst has been reported. The procedure is simple, environmental benign and has the advantage of enhanced atom economy. Furthermore, the catalyst can be recovered and reused efficiently number of times without substantial loss of catalytic activity.

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PP-244 Mild, Efficient Synthesis and Antimicrobial Activity of (E)-2-(benzo[d]thiazol- 2-yl)-3-phenylacrylonitrile Derivatives using ZnFe2O4 in Ethanol at Ambient Temperature. Pramod D. Jawale Patil, [a] Rajita D. Ingle, [a] Sidhanath V. Bhosale,[b] Rajendra P. Pawar*[a] a Department of Chemistry, Deogiri college, Aurangabad-31005 b Polymer and Functional Material Division, CSIR-Indian Institute of Chemical Technology, (CSIR-IICT), Hyderabad-500607 *Corresponding author: [email protected], [email protected]

Abstract: The development of practical, environmentally benign and highly economic protocols for the synthesis of heterocyclic compounds has remained to be a challenging task for researchers in synthetic organic chemistry. Herein we developed a mild and efficient protocol for the synthesis of (E)-2- (benzo[d]thiazol-2-yl)-3-phenylacrylonitrile derivatives from 2-(benzo[d]thiazol-2-yl) acetonitrile and various aromatic aldehydes by using ZnFe2O4 as a heterogeneous catalyst in ethanol at ambient temperature. All the synthesized compounds were screened for antimicrobial activity; most of them showed moderate antimicrobial activity. Short reaction times, avoidance of toxic solvents, high yields and no needs of column chromatographic purification are the valuable features of the present protocol.

PP-245 The Effect of Bis-Carboxylic Groups of Squarylium Dyes on the Performance of Dye-Sensitized Solar Cells Sultan A. Al-horaibi, Eman M. Garoon, Suresh T. Gaikwad, Anjali S. Rajbhoj*

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra 431001, India. *Corresponding author: [email protected], [email protected], Abstract: Symmetric squarylium dye (SQIND-1) with bi-carboxylic groups has been synthesized and photovoltaic properties have been studied in comparison with its non-functionalized analogue groups (SQIND-2). The experimental results showed that the introduction of anchor carboxylic groups in SQIND-1 sensitizer provides a more intimate contact with nanoparticles TiO2 which increases the number of charge carriers transferred from the SQIND-1 to the semiconductor. The theoretical calculations and absorbance results show that the electron density of LUMO of SQIND-1 is delocalized in the whole chromophore, leading to strong electronic coupling between SQIND-1 sensitizer and conducting band of TiO2, resulting in improved dye-sensitized solar cell efficiency compared to SQIND-2. Hence, the SQIND-1 sensitized exhibit better photovoltaic performance. Although, the absence of any linker groups in the SQIND-1, then SQIND-1 was perfect efficiently sensitized on porous TiO2 with the long UV-Vis and NIR region up to 800 nm of the spectrum and showed higher remarkable performance of values, such as an η of 3.3%, a Jsc of 7.6 mA/cm2, a Voc of 0.59 and a FF of 0.73.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 158 Exploring New Horizons in Chemical Sciences-2019

PP-246 A Highly Sensitive Electrochemical Senor by Using Zinc Oxide Nanostructure- Modified Glassy Carbon Electrode for the Determination of Dopamine. Methaq Al-Hubaishi, Suresh Gaikwad, Anjali Rajbhoj*

Department of Chemistry, Dr. Babasaheb Ambedkar Marthwada University, Aurangabad, India.

*Corresponding author: [email protected]

Abstract: In this study, an electrochemical dopamine sensor was constrcuted on glassy carbon electrode modifide with zinc oxide nanostrcture(ZnO NS) by using Cyclic Voltametry(CV) and Differential Pulse Voltametry (DPV) methods. ZnO NS was synthesized via electrochemical reduction method by using zinc foil as scarificial anode and platenum foil as cathode. Tetrapropylammonuim bromide was used as capping agent in aqueous solution at 18 mA/cm2 current density. FTIR, XRD, FESEM and HRTEM results showed that ZnO NS were pure and polycrystalline with a hexagonal wurtzite phase and have rod and spherical shaped with size 53.9 nm. The ZnO NS –GCE modifide electrode observed reversible behavior with ferricynide system which had about 2.94 times more surface area and exhibited higher currents for dopamine oxidation and reduction compared to bare GCE. Dopamine was sensed in range of 50 µM to 350 µM. From the linear regression plotted R2 = 0.914 and R2= 0.987, the sensitivity was found to be 0.477 µA/µM.cm2 and 0.636 µA/µM.cm2. The detection limit was found to be 2.9 µM. These results indicated that ZnO NS exhibited good platform and could be used for voltametric determination of dopamine.

Keywords: Electrochemical Reduction Method, Cynclic Voltammetry , ZnO NS, Dopamine, Electrochemical Sensor.

PP-247 Synthesis, Characterization and Temperature Dependent Study of SAPO-11

G. S. Duthade1*, U. D. Joshi, Mahendra Lokhande3

1 Department of Physics, Yeshwant Mahavidyalaya, Nanded (M.S, India) 2 Principal, Yogeshwari Mahavidyalaya Ambajogai, Dist. Beed (M.S, India) 3Department of Chemistry, Avviyar Goverment College for Women, Karaikal, 69602 Affiliated to Pondecharry University, India. Corresponding author: [email protected]

Abstract: SAPO-11 molecular sieves synthesized successfully by hydrothermal method, using a single agent di-n- propylamine (DAP) as an organic template. The effect of the temperature on crystallization of synthesized product was studied. Obtained powder form of the sample was calcined at 550OC for 5½ hours to remove single agent, to get high crystallization. Properties of the final product ware investigated. The synthesized sample ware characterized by XRD and IR techniques. Result revealed that the acidic character of the product increases with increase in temperature. It shows that effect of temperature plays an important role in formation of product with varied bonding in Si-P.

Keywords: Hydrothermal, SAPO-11, Characterization, Catalytic activity, Powder X-RD

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PP-248 Physico Chemical Studies of Heavy Metal Content of Ground Water: Challenges and Opportunities Ansari Farzana W1* 1Department of Chemistry, J.A.T Arts, Science and Commerce College (for women), Malegaon Dsit. Nashik, 423203,

*Corresponding author: [email protected]

Abstract: Water has been central to all life forms since the Big Bang and hence has the capacity to promote life on this planet and acts as universal solvent. Fast industrialization and urbanization has caused purity of surface and ground water at risk causing contamination in both reserves of potable water. Heavy metals like Pb, Cd, Hg, Cu, Zn, As, Sb are found in various water samples in study, which is cause for potential risk to living beings. This work is aimed at the comparison of reported work with the US EPA data for admissible limits and to account for the study of areas covered under study. Four reported work are were assessed for heavy metal contamination with reference to EPA Drinking water Standards and found much variation in the concentrations with changing climatic conditions. More challenges are ahead for coming researchers to study physical, chemical and geochemical studies of water in future vis a vis provides opportunity to study the groundwater content of traces of elemental metals and their impact on living beings.

Keywords: Groundwater, Heavy metals, contamination, surface water

PP-249 Extraction of Active Constituent of Ipomoea Carnea byusing Ultra Sonication and Study of Anti-Bacterial Activity Shubham Sawant, Indranil Suryawanshi, Pawan Yeole, D. S. Bhagat*

Department of Forensic Chemistry and Toxicology, Government Institute of Forensic Science, Aurangabad-431005 (M.S.)

*Corresponding author: [email protected]

Abstract: Ipomoea Carnea belong Convolvulaceae family. It is popularly known as Besharam (Marathi), Bahaya (Hindi) and morning glory (English).It is mainly found in aquatic, muddy and terrestrial environment. This plant found in almost all parts of world. The plant extract shows excellent antibacterial, antifungal, antioxidant and wound healing activity. The extract of Ipomoea Carnea contains alkaloids, fatty acid, phenol’s flavanoids, ester and steric acid. The active ingredients of Ipomoea Carnea show better extraction in methanol and diethyl ether by solvent extraction. The extraction of active ingredient was done by ultrasonication. The ultrasonicwave increases the efficiency of extraction.The crude extract of Ipomoea Carnea shows excellent anti-microbial activity against E. coli and proteus vulgaris.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 160 Exploring New Horizons in Chemical Sciences-2019

PP-250 Synthesis of Chemosensor and Study of Its Application for Detection of Toxic Metal Ions - A Forensic Approach

P. B. Chavan, S. N. Tapase, R. R. Rangari, S. G. Pande, D. S. Bhagat1*

Department of Forensic Chemistry and Toxicology, Government Institute of Forensic Science, Aurangabad-431005 (M.S.)

*Corresponding author: [email protected]

Abstract: In recent decades increase in industrialization results into pollution of metal ions in environment. These metal ions interact with living systems and cause hazardous effects on human health, which results into intoxication and poisoning.So, the identification and quantification of metal ions became essential part in investigation of toxic metal ion poisoning cases in field of forensic science. Thechemosensor is a sensory receptor that shows detectable change in colour and photophysical properties. In present work, the ultrasonicator assisted synthesis of chemosensor using benzoyl chloride and diethylenetriamine in acetonitrile was carried out.Synthesized chemosensor is confirmed by TLC, UV-VIS spectroscopy and FT-IR. The synthesizedchemosensor interacts with metal ions and produce a notable change in colorimetric measurements. It is observed that as concentration of metallic ions increases, absorbance also increases. So chemosensor can be used for quantitative estimation.

PP-251 Functionalized silver nanoparticle as a probe for the detection of lindane

S. N.Tapase, N. D. Deshpande, A. A. Sukhadeve*, S. G. Pande

Department of Forensic Chemistry and Toxicology, Government Institute of Forensic Science, Aurangabad-431005 (M.S.)

*Corresponding author:[email protected]

Abstract: Nanotechnology is a developing field in chemical science. Nanotechnology is highly efficient and sophisticated technique in chemical analysis and therapeutic treatments. Silver nanoparticles are popularly recognized for their simple, easy and cheap method of synthesis. Silver nanoparticles are highly sensitive and show notable change even in less concentration. In present work the ultrasonicator assisted functionalized silver nanoparticles are used for detection of hexachlorocyclohexane (lindane) pesticide in various spiked samples. The interaction between lindane and silver nanoparticles was studied by Colour test, TLC, UV-Visible and FT-IR spectrophotometer. Present study shows that the citrate capped silver nanoparticles can be effectively used for detection of hexachlorocyclohexane (lindane) pesticide in various spiked samples.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 161 Exploring New Horizons in Chemical Sciences-2019

PP-252 Synthesis, characterization and transition metal complex of 3H-1, 2, 4-triazole- 3-thione, 2, 4-dihydro-4-[[(2-hydroxy-4-methoxyphenyl) methelene] amino]- ligand and their microbial studies

Someshwar P. Bhalea, Ashok R. Yadava, Pintu G. Patharea, Atam B. Tekaleb, Rajendra P. Pawara*

aDepartment of Chemistry, Deogiri College, Aurangabad-431005, MS, India. bDepartment of Chemistry, Shri Shivaji College,Parbhani-431401, MS, India

*Corresponding author:[email protected]

Abstract: A novel nitrogen containing 3H-1,2,4-triazole-3-thione,2,4-dihydro-4-[(2-hydroxy-4-methoxyphenyl) methelene]amino ligand(H2L)was synthesized by using equimolar ratio of 4-amino-1,2,4-triazole-3- thioneand 2-hydroxy-4-methoxybenzaldehyde. Aseries of Mn (II), Fe (II), Co (II), Ni (II), Cu (II), Zn (II), Cd (II) transition metal complexes were preparedby1:1 ratio. The structure of synthesized ligand and their metal complexes were characterized byusing IR, 1HNMR, 13CNMR, Mass spectrometry, UV, Powder XRD andTGA investigation method. On the basis of spectral data it was found that ligand acts as tridentate SNO donor. Synthesized H2L ligand and their metal complexes were screened for antimicrobial activity.The biological activity result show that the transition metal complexes have moreantifungal as well as antibacterial activity than the parent H2L ligand against one or more microbial species.

Keywords: SNO donor ligand, transition metal complexes, spectroscopic analysis, antimicrobial activity.

PP-253 Synthesis, Antimicrobial Activity of Substituted Fluoro- N-((1, 3-diphenyl-1H- pyrazol-4-yl) methylene) benzenamines and Fluoro-3-phenyl-2-(1, 3-diphenyl- 1H-pyrazol-4-yl) thiazolidin-4-ones Sunil S. Bhagat1*, Balaji D. Rupnar1, Amol J. Shirsat1, Ajit K. Dhas2, Charansingh H. Gill3

1Department of Chemistry, R. B. Attal Arts, Science & Commerce College, Georai, Beed, Maharashtra, India. 2Department of Chemistry, Deogiri College, Aurangabad, Maharashtra, India. 3Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India. *Corresponding author:[email protected] Abstarct: Nitrogen- and sulfur-containing heterocycles play an important role, not only for life science, but also in many other industrial fields related to special and fine chemistry. The chemistry of thiazolidin-4-one ring systems is of considerable interest as it is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities. In addition to this pyrazole also shows unique pharmaceutical activity. Herein we report synthesis of thiazolidin-4-one from various substituted formyl pyrazole and substituted fluoroaniline.

Keywords: Schiff bases, Pyrazole imines, 4-thiazolidinone., antimicrobial, Gram +ve and Gram –ve microorganisms

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 162 Exploring New Horizons in Chemical Sciences-2019

PP-254 Synthesis and antibacterial evaluation of some 2,4-dichloro-6-(2-(5-Chloro-3- methyl-1-phenyl-1H Pyrazol-4-yl)2,3-dihydro-1H-benzo[b][1,4]diazepine- 4yl)phenol Derivative Shaikh Abdul Baseer Department of Chemistry, Sir Sayyed College Roshan Gate Aurangabad 431001.

*Corresponding author: [email protected]

Abstract: An simple, efficient access, single step and environmentally benign synthesis of a new series of pyrazole containing 2,4-dichloro-6-(2-(5-Chloro-3-methyl-1-phenyl-1H Pyrazol-4-yl)2,3-dihydro-1H- benzo[b][1,4]diazepine-4yl)phenol Derivativewas described here by the condensation of chalcones with o-phenylenediamine using piperidine in polyethylene glycol (PEG-400) as a reaction solvent. The advantages of this protocol are easy work-up, excellent yield, mild reaction condition and avoidance of volatile organic solvent. Furthermore, these newly synthesized compounds were screened for their antimicrobial activity.

Keywords: PEG-400, Chalcones, o-Phenylenediamine, and Antimicrobial activity

PP-255 Production of Polybetahydroxybutyrate (PHB) by Bacterial species isolated fromrhizospheric soil samples of Osmanabad region. P. S. Jakotiya, S. D. Patil and R. M. Khobragade* Department of Microbiology, Dr. Babasaheb Ambedkar Marathwada University, Sub-campus, Osmanabad 413501 (M.S.) *Corresponding author: [email protected] Abstract: Plastic material has become an integral part in our daily life as a basic need, but it is causing serious environmental problems. Synthetic polymers obtained from petrochemicals cause air pollution on combustion as well as they are non-degradable in soil for long time. A microbial plastic PHB has gained importance because of its easily completely degradable nature. PHB's are reserve material polymer produced by a range of bacteria. They are accumulated as granules which are stored in the form of carbon & energy materials. The present study aims, isolation & production of PHB from Bacillusspecies isolated from rhizospheric soil samples of different crops. The total 25 different bacteria (C1 to C25) were isolated from the soil samples collected from rhizosphere of different crop plants located in Osmanabad region. Out of these 8 isolates were found to be PHB positive. All 8 PHB positive isolates were subjected to different production media. Production of PHB was quantitatively estimated by using UV-VIS Spectrophotometer. Mediaused M-9 media & Minimal Salt Media showed PHB yield in the range of 34.69 to 50.76 mg/ml and 70.52 to 77.59 mg/ml respectively. The C1 colony showed highest yield of PHB and it was 70.40 mg/ml. These isolates can be used further for the production of PHB on large scale.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 163 Exploring New Horizons in Chemical Sciences-2019

PP-256 Synthesis and Characterization of Mixed Ligand Complexes of Vanadium Using Diazo Compounds of 2-Amino Phenol and Salicyldehyde With 3-Nitroaniline and 4-Nitroaniline

1Sonaji V. Gayakwad, 2Vikas D. Ragole and 3Dnyaneshwar S. Wankhede 1Department of Chemistry, Mrs. K.S.K. College, Beed (MS) 2Late Ramesh Warpudkar Art’s, Commerce and Science College Sonpeth, Dist Parbhani (MS) 3School of Chemical Sciences, S.R.T.M. University, Nanded (MS)

*Corresponding author: [email protected] Abstract: In this article presents synthesis of mixed ligand complexes of vanadium metal by using diazo compounds as ligands. The diazo compounds of 3-nitroaniline and 4-nitroaniline with salicyldehyde and 2-aminophenol by using diazotization reaction using sodium nitrate. Four different ligand molecules, 4 (4-Nitro) benzoazosalicyldehyde (L1), 4(3-Nitro) benzoazosalicyldehyde (L2), 4(4-Nitro) benzoazoaminophenol (L3) and 4(3-Nitro) benzoazoaminophenol (L4) were prepared by using above mention compound and synthesis of their mixed ligand complexes with vanadium metal at room temperature. The structures of both diazo ligands and their complexes were identified by elemental analyses, FT-IR, 1H-NMR, UV-VIS, magnetic susceptibility, and mass spectral data.

Keywords: Diazoligands, Vanadylsulphate, 3-Nitroaniline, 4-Nitroaniline, Salicyldehyde, 2- Aminophenol

PP-257 Synthesis of Tetradentate Ligands by Using Propane-1, 3-diamine and Substituted 2-Hydroxybenzaldehyde. Sachin A. Khiste1, Prashant K. Vibhute2, Mukesh S. Kadam3, Dnyaneshwar S. Wankhede4

1. Department of Chemistry, Vaishnavi Mahavidyalaya, Wadwani Dist. Beed. 2. Department of Chemistry, Balbhim College, Beed. 3. Department of Chemistry, LGMACS College, Mandangad Dist. Ratnagiri. 4. School of Chemical Sciences, S.R.T.M.University, Nanded.

*Corresponding author: [email protected]

Abstract: In this work compound III were synthesized and characterized with the help of IR, 1H NMR and mass spectrometry. It acts as tearadentate ligand1 with transition and inner transition metals. Propane-1, 3-diamine (I) (1 mmol) and substituted 2-hydroxybenzaldehyde (II) (2 mmol) in the molar ratio 1:2 were dissolved in methanol. Acid catalyst (0.1 mmol) was added to this solution and heated at reflux for 2 hrs. After completion of the reaction as seen from the TLC, methanol was removed under reduced pressure. The reaction was quenched with sat. NaHCO3 (20 ml) and extracted with DCM (20 ml x 3). Combined organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure to get the desired compound (III) as yellow liquid.

OH Dil.HCl N N H2N NH2 2 O Methanol R R R OH HO I II III

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 164 Exploring New Horizons in Chemical Sciences-2019

PP-258 Enantioselective Synthesis of (+)-Safinamide: Anti-Parkinson Agent Using D- proline catalyzed α-amination reaction

Sanjay S. Gaikwad* Department of Chemistry, MES Abasaheb Garware College, Pune

*Corresponding author: [email protected] Abstract: Highly enantioselective synthesis of anti-Parkinson agent, Safinamide is achieved from L-proline catalyzed - amination of propanal in 5 steps. Described route can provide easy access to congeners like ralfinamide.

NH R N 2 H R' O O

R = F, R' = H (+)-Safinamide (1) R = H, R' = F (+)-Ralfinamide(2)

We have developed first synthetic approach to (+)-safinamide starting form achiral starting material. We obtained (+)-safinamide in 39% overall yield. This route provides easy access to the congeners of (+)- safinamide and avoids hazardous reagents. PP-259 Smart Polymers: Synthesis and Applications

1Kalpana N. Handore, 1Sumit B. Sharma, 2Santosh Mishra, 3Vasant V. Chabukswar* 1Modern Education Society’s College of Engeneering (MESCOE), Pune 2G. H. Raisoni College of Engeneering and Management, Pune 3Department of Chemistry, Nowrosjee Wadia College. 19, Late Prin. V. K. Joag Path, Pune- 411001. Maharashtra (India).

*Corresponding author: [email protected]

Abstract: Smart and intelligent hybrid polymeric materials havecharacteristic property that changes according to the environment also called as stimuli responsive polymer. This hybrid polymeric materials are sensitive to number of factors including humidity, temperature, chemicals, electrical and magnetic fields and responds in various ways, like altering the color or transparency, becoming conductible or permeable to water or changing shape. Shape memory polymers shows sufficient changes in polymer propertieson changing environmental condition. Smart polymeric hybrid materials are used for the production of hydrogels, biodegradable packaging and biomedical engineering applications. Biopolymers which are humidity sensitive used in self adaptive wound dressing. Conducting polymeric nanocomposites are also used as sensors, catalyst in organic synthesis. The present work is focused on the entire features of smart polymers, characterization techniques and their relevant applications in various field.

Keywords: Smart hybrid polymers, Stimuli responsive materials, hydrogels, biodegradable packaging, conducting polymer nanocomposite.

International Symposium Organized by Department of Chemistry Deogiri College, Aurangabad (MS) India Page 165