USA College of Medicine Annual Report 2017-2018
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2017-2018 COM ANNUAL REPORT COM ANNUAL 2017-2018 ANNUAL REPORT COLLEGE OF MEDICINE October 1, 2017 – September 30, 2018 USA College of Medicine niagOr tiza Chlaon ar t April, 2018 e d VP for M ical Affairs sst. Dea n , Dean, College of Medicine Medical Science Foundation Board ance &Joh n V. Marymont M.D., M.B.A n R . S A uniF sa Administration Director, trkeMa ing & Commun., COM e s S ansing Paul Taylor rP ident, Medical Science Foundation John V. Marymont, M.D., M.B.A. I. T o Se Anior ssociate Dean, COM Mary wnsley, Ph.D Associate Dean, Asst. VP Medical Affairs, Interim Chair, B coi hemistry & Associate Dean, Faculty Affairs Chair, Emergency Medicine Medical Education & Student Affairs Assoc. Dean, Diversity & Inclusion Molecular Biology Vacant Edward A. Panacek, M.D., M.P.H. Susan P. Ledoux, Ph.D. R. Franklin Trimm, M.D. Jonathan G. Scammell, Ph.D. Division of Medical Education Director, Faculty Affairs t ion Nicole C. Schultz, M.S. Assistant Dean, Diversity & Inclusion Chair, Compa ar tive Medicine Chai ,r Family Medicine Johnson Haynes, M.D. Jonathan G. Scammell, Ph.D. R. Allen Perkins, M.D., .M.P H. Assistant Dean, Medical Educa Assista n Benj niam Estrada, M.D. Assistant Dean, Accreditation & Planning Timothy Gilbert, Ph.D. t Dean and DIO, GME Chair, Microbiology & Immunology Chair, Internal Medicine Assistant Dean, Medical Education Samuel McQuiston, M.D. David O. Wood, Ph.D. Errol D. Crook, M.D. Anthony L. Gard, Ph.D. Assistant Dean, Admissions Jonathan G. Scammell, Ph.D. , Ph Assistant Dean, Medical Education Director, Sickle Cell Center Chair, Pharmacology Chair, Neurology Jeffrey S. Sosnowski, M.D .D. Johnson Haynes, M.D. Mark N. Gillespie, Ph.D. Dean K. Naritoku, M.D. Director, Admissions Assista n Mark Scott Office of Student Affairs Director Chair, Physiology and Cell Biology Chair, Neurosurgery Center for Healthy Communities Te r e y, Director, Anatomical Gifts Troy Stevens, Ph.D. Anthony M. Martino, M.D. t Dean, Student Affairs Errol D. Crook, M.D. ry J. Hundl M.D. Vaughn Lee, Ph.D. Co-Director, Research Ed. & Training, Dir ce tor, Center for Lung Biology Chair, OB/GYN Assistant Dean, Student Affairs a , Pipeline & Career Development Troy Stevens, Ph.D. Lisa B. Spiryda, M.D., Ph.D. Kelly P. Roved M.D. Thomas C. Rich, Ph.D. Co-Director, Research Ed. & Training, Director, Health Sciences Educational Technology & Svcs. Graduate Program Chair, Orthopaedics Development & Alumni Relations Mark S. Taylor, Ph.D. Richard M. Marks, M.D. Mul mit edia Production Manager Racheal B. Banks Joanne K. Brookfield Director, USA Health System Grants Administration & Development Interim Co-Chairs, Pathology D ri ector, Student Health C il nic Ashley Turbeville, M.B.A.,C.R.A. Andrea Kahn, M.D., Beverly Kellen Elliot Carter M.D. Manager, COM Support Services Marcina Lang, M.P.A. Chair, Pediatrics David A. Gremse, M.D. Operations Manager, COM Research Facilities Howard Shell tor , Chair, Psychiatry Direc Radiation & Laser Safety Ronald D. Franks, M.D. David Wiik i ol r for Interim Director, Chair, Rad ogy Cente Strategic Health Innovation Maria Figarola, M.D. Susan R. Sansing Director, Center for Disaster Healthcare Preparedness Chair, Surgery David L. Wallace William O. Richards, M.D. Director, Co nnti uing Medical Educa it on Shar ir e Cranford, LGSW ANNUAL REPORT UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE October 1, 2017 through September 30, 2018 TABLE OF CONTENTS Page I. Reports from Departments and Centers Biochemistry and Molecular Biology .........................................................................1 Comparative Medicine ................................................................................................5 Emergency Medicine ...................................................................................................7 Family Medicine .........................................................................................................11 Internal Medicine .......................................................................................................13 Microbiology and Immunology ................................................................................22 Neurology ....................................................................................................................27 Neurosurgery ..............................................................................................................34 Obstetrics and Gynecology........................................................................................36 Orthopaedic Surgery .................................................................................................41 Pathology ....................................................................................................................44 Pediatrics ....................................................................................................................47 Pharmacology .............................................................................................................59 Physiology and Cell Biology ......................................................................................65 Psychiatry ...................................................................................................................72 Radiology ....................................................................................................................75 Surgery ........................................................................................................................80 Center for Lung Biology ............................................................................................92 Center for Healthy Communities .............................................................................95 Center for Strategic Health Innovation ...................................................................98 Center for Disaster Preparedness...........................................................................101 Comprehensive Sickle Cell Center .........................................................................104 II. Report from Office of Development and Alumni Relations .......................................107 III. Report from Division of Medical Education and Student Affairs .............................110 IV. Report from Admissions................................................................................................125 V. Report from Continuing Medical Education ..............................................................128 VI. Report from Graduate Medical Education .................................................................129 VII. Report from Medical Student Summer Research Program ......................................134 VIII. Report from the Graduate Program in Basic Medical Sciences ................................139 IX. Summary of Extramural Support ................................................................................143 2017-2018 Summary of Scholarly Activities Department of Biochemistry & Molecular Biology I. PUBLISHED JOURNAL ARTICLES, BOOK CHAPTERS, AND PATENTS Balczon R, Francis M, Leavesley S, Stevens T. Methods for detecting cytotoxic amyloids following infection of pulmonary endothelial cells by Pseudomonas aeruginosa. J Vis Exp. 2018 Jul 12;(137):e574447. Available from: https://www.jove.com/pdf/57447/jove- protocol-57447-methods-for-detecting-cytotoxic-amyloids-following-infection Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W. PP1: tautomycetin complex reveals a path toward the development of PP1- specific inhibitors. J Am Chem Soc. 2017 Dec 13;139(49):17703-17706. Hamilton CL, Abney KA, Vasauskas AA, Alexeyev M, Ni L, Honkanen RE, Scammell JG, Cioffi DL. Serine/threonine phosphatase 5 (PP5C/PPP5C) regulates the ISOC channel through a PP5C-FKBP51 axis. Pulm Circ. 2018 Jan-Mar;8(1):2045893217753156. Available from: http://journals.sagepub.com/doi/pdf/10.1177/2045893217753156 Hamilton CL, Kadeba PI, Vasauskas AA, Solodushko V, McClinton AK, Alexeyev M, Scammell JG, Cioffi DL. Protective role of FKBP51 in calcium entry-induced endothelial barrier disruption. Pulm Circ. 2018 Jan-Mar;8(1):2045893217749987. Available from: http://journals.sagepub.com/doi/pdf/10.1177/2045893217749987 II. PUBLISHED ABSTRACTS Abney K, Grankvist N, Nilsson R, Swingle MR, D’Arcy B, Papke CM, Rusin SF, Kettenbach A, Honkanen RE. CRISPR-Cas9 mediated disruption of PPP5C expression in human cells enabled the identification of novel roles for PP5C in metabolism and provide molecular insights to help explain why PPP5C-/- mice exhibit reduced fasting glycaemia and resistance to high fat diet-induced weigh gain. FASEB 2018 Science Research Conferences: Protein Phosphatases; 2018 Jul 15-20; Snowmass, CO. Abstract no. P32. Berrou M, Stevens R, Voth SB, Caesar Williams CD, Balczon R, Stevens T. Pseudomonas aeruginosa induced lung endothelial amyloid proteinopathy: characteristics and inhibitors. Am J Respir Crit Care Med. 2018;197:A5724. Available from: https://www.atsjournals. org/doi/pdf/10.1164/ajrccm-conference.2018.197.1_MeetingAbstracts.A5724 Haldar B, Hamilton CH, Solodushko V, Scammell JG, Cioffi DL. The role of S100A6 in the PP5C-FKBP51-mediated inhibition of endothelial ISOC. FASEB J. 2018;32:917.1. Kim JH, Stone JK, Li J, Richard A, Vukadin L, Gillespie GY, Sobol RW, Lim ST, Ahn EYE. SON controls the oncogenic alternative splicing program in glioblastoma by regulating PTBP1/2 switch and RBFOX2 activity. American Association for Cancer Research 2018 Annual