Table S2: Differentially expressed identified by the human array platform. Highlighted genes were identified by more than one probe. Fold- p-value Probeset ID Symbol Gene Title Change (BIS/IIS) (BIS/IIS) 204948_s_at Fst follistatin 3.891 0.000 211571_s_at Vcan versican 2.762 0.001 CDC28 kinase regulatory 204170_s_at Cks2 2.551 0.006 subunit 2 eukaryotic translation initiation factor 201123_s_at Eif5a 2.532 0.000 5A heat shock protein 90kDa alpha 211969_at Hsp90aa1 2.397 0.001 (cytosolic), class A member 1 200750_s_at RAN, member RAS oncogene family 2.359 0.000 207345_at Fst follistatin 2.267 0.000 213911_s_at H2afz H2A histone family, member Z 2.120 0.002 203570_at Loxl1 lysyl oxidase-like 1 2.119 0.006 201090_x_at Tuba1b , alpha 1b 2.077 0.000 211072_x_at Tuba1b tubulin, alpha 1b 2.019 0.001 212639_x_at Tuba1b tubulin, alpha 1b 2.011 0.001 213646_x_at Tuba1b tubulin, alpha 1b 1.983 0.001 218073_s_at Ndc1 NDC1 transmembrane nucleoporin 1.943 0.004 proteasome (prosome, macropain) 200987_x_at Psme3 activator subunit 3 (PA28 gamma; 1.913 0.002 Ki) heterogeneous nuclear 209330_s_at Hnrnpd ribonucleoprotein D (AU-rich element 1.905 0.023 RNA binding protein 1, 37kDa 201787_at Fbln1 fibulin 1 1.898 0.001 37793_r_at Rad51d RAD51 homolog D (S. cerevisiae) 1.866 0.001 heterogeneous nuclear 221481_x_at Hnrnpd ribonucleoprotein D (AU-rich element 1.862 0.002 RNA binding protein 1, 37kDa 217733_s_at Tmsb10 thymosin beta 10 1.855 0.008 heterogeneous nuclear 200073_s_at Hnrnpd ribonucleoprotein D (AU-rich element 1.850 0.001 RNA binding protein 1, 37kDa 213476_x_at Tubb3 tubulin, beta 3 class III 1.848 0.004 polymerase (RNA) II (DNA directed) 213887_s_at Polr2e 1.846 0.010 polypeptide E, 25kDa 217786_at Prmt5 protein arginine methyltransferase 5 1.822 0.000 207688_s_at Inhbc inhibin 1.805 0.045 heat shock 60kDa protein 1 200807_s_at Hspd1 1.797 0.001 (chaperonin) 217356_s_at Pgk1 phosphoglycerate kinase 1 1.784 0.011 211750_x_at Tuba1c tubulin, alpha 1c 1.783 0.001 209251_x_at Tuba1c tubulin, alpha 1c 1.781 0.000 210220_at Fzd2 frizzled family receptor 2 1.772 0.002 211784_s_at Srsf1 serine/arginine-rich splicing factor 1 1.754 0.003 203418_at Ccna2 cyclin A2 1.746 0.006 211058_x_at Tuba1b tubulin, alpha 1b 1.745 0.000 heterogeneous nuclear 201277_s_at Hnrnpab 1.743 0.000 ribonucleoprotein A/B 215438_x_at Gspt1 G1 to S phase transition 1 1.742 0.005 synaptotagmin binding, cytoplasmic 217834_s_at Syncrip 1.737 0.004 RNA interacting protein protein phosphatase, Mg2+/Mn2+ 200913_at Ppm1g 1.730 0.006 dependent, 1G chaperonin containing TCP1, subunit 200877_at Cct4 1.727 0.002 4 (delta) 208863_s_at Srsf1 serine/arginine-rich splicing factor 1 1.715 0.005 heat shock protein 90kDa beta 200598_s_at Hsp90b1 1.712 0.011 (Grp94), member 1 tyrosine 3- monooxygenase/tryptophan 5- 213655_at Ywhae 1.703 0.004 monooxygenase activation protein, epsilon (YWHAE) proteasome (prosome, macropain) 201198_s_at Psmd1 1.699 0.005 26S subunit, non-ATPase, 1 218051_s_at Nt5dc2 5'-nucleotidase domain containing 2 1.690 0.001 eukaryotic translation initiation factor 201530_x_at Eif4a1 1.688 0.019 4A1 202779_s_at Ube2s ubiquitin-conjugating E2S 1.686 0.009 214845_s_at Calu calumenin 1.683 0.003 201742_x_at Srsf1 serine/arginine-rich splicing factor 1 1.677 0.029 203411_s_at Lmna lamin A/C 1.676 0.001 200754_x_at Srsf2 serine/arginine-rich splicing factor 2 1.672 0.002 216953_s_at Wt1 Wilms tumor 1 1.668 0.015 221348_at Nppc natriuretic peptide C 1.662 0.048 macrophage migration inhibitory 217871_s_at Mif 1.662 0.008 factor (glycosylation-inhibiting factor) 219118_at Fkbp11 FK506 binding protein 11, 19 kDa 1.655 0.003 synaptotagmin binding, cytoplasmic 217832_at Suncrip 1.654 0.004 RNA interacting protein 201912_s_at Gspt1 G1 to S phase transition 1 1.651 0.006 202154_x_at Tubb3 tubulin, beta 3 class III 1.628 0.004 phosphoribosyl pyrophosphate 215486_at Prps1l1 1.618 0.001 synthetase 1-like 1 205535_s_at Pcdh7 protocadherin 7 1.614 0.008 heterogeneous nuclear 205292_s_at Hnrnpa2b1 1.605 0.005 ribonucleoprotein A2/B1 213726_x_at Tubb4b tubulin, beta 4B class IVb 1.594 0.001 proteasome (prosome, macropain) 201114_x_at Psma7 1.594 0.000 subunit, alpha type, 7 AC004941.5 /// 217027_x_at OTTHUMG000 NULL /// NULL 1.589 0.002 00151502 eukaryotic translation initiation factor 211787_s_at Eif4a1 1.588 0.002 4A1 202899_s_at Srsf3 serine/arginine-rich splicing factor 3 1.565 0.007 AFFX- HUMGAPDH/ glyceraldehyde-3-phosphate Gapdh 1.564 0.004 M33197_M_a dehydrogenase t proteasome (prosome, macropain) 200786_at Psmb7 1.562 0.003 subunit, beta type, 7 200853_at H2afz H2A histone family, member Z 1.557 0.000 eukaryotic translation initiation factor 208726_s_at Eif2s2 1.549 0.000 2, subunit 2 beta, 38kDa 200020_at Tardbp TAR DNA binding protein 1.549 0.006 208775_at Xpo1 exportin 1 (CRM1 homolog, yeast) 1.547 0.020 201585_s_at Loc100996496 uncharacterized LOC100996496 1.542 0.013 proteasome (prosome, macropain) 201400_at Psmb3 1.542 0.013 subunit, beta type, 3 203109_at Ube2m ubiquitin-conjugating enzyme E2M 1.541 0.017 ATPase, Ca++ transporting, cardiac 209186_at Atp2a2 1.541 0.050 muscle, slow twitch 2 200680_x_at Hmgb1 high mobility group box 1 1.531 0.001 nuclear autoantigenic sperm protein 201970_s_at Nasp 1.524 0.004 (histone-binding) proteasome (prosome, macropain) 209853_s_at Psme3 activator subunit 3 (PA28 gamma; 1.522 0.006 Ki) heterogeneous nuclear 211931_s_at Hnrnpa3 1.516 0.020 ribonucleoprotein A3 Sjogren syndrome/scleroderma 203114_at Sssca1 1.510 0.031 autoantigen 1 eukaryotic translation initiation factor 200004_at Eif4g2 1.507 0.001 4 gamma, 2 221613_s_at Zfand6 zinc finger, AN1-type domain 6 -1.504 0.009 209031_at Cadm1 cell adhesion molecule 1 -1.514 0.011 214505_s_at Fhl1 four and a half LIM domains 1 -1.518 0.012 209099_x_at Jag1 jagged 1 -1.523 0.012 202583_s_at Ranbp9 RAN binding protein 9 -1.525 0.020 209216_at Wdr45 WD repeat domain 45 -1.537 0.004 217165_x_at Mt1f metallothionein 1F -1.550 0.005 217572_at -1.553 0.018 209905_at Hoxa9 homeobox A9 -1.556 0.001 214414_x_at Hba2 hemoglobin, alpha 2 -1.562 0.026 cytochrome P450, family 26, 206424_at Cyp26a1 -1.565 0.048 subfamily A, polypeptide 1 platelet-derived growth factor 203131_at Pdgfra -1.575 0.004 receptor, alpha polypeptide REV3-like, polymerase (DNA 208070_s_at Rev3l -1.575 0.002 directed), zeta, catalytic subunit 214988_s_at Son SON DNA binding protein -1.580 0.009 B-cell translocation gene 1, anti- 200920_s_at Btg1 -1.581 0.001 proliferative growth arrest and DNA-damage- 203725_at Gadd45a -1.585 0.023 inducible, alpha insulin-like growth factor binding 201162_at Igfbp7 -1.588 0.005 protein 7 PNN-interacting serine/arginine-rich 212176_at Pnisr -1.607 0.003 protein 212071_s_at Sptbn1 spectrin, beta, non-erythrocytic 1 -1.608 0.001 213033_s_at Nfib nuclear factor I/B -1.621 0.002 BTB and CNC homology 1, basic 221234_s_at Bach2 -1.627 0.005 leucine zipper transcription factor 2 potassium large conductance 221584_s_at Kcnma1 calcium-activated channel, subfamily -1.642 0.002 M, alpha member 1 A kinase (PRKA) anchor protein 8- 218064_s_at Akap8l -1.647 0.032 like RNA binding protein with multiple 209488_s_at Rbpms -1.659 0.017 splicing 203992_s_at Kdm6a lysine (K)-specific demethylase 6A -1.660 0.000 SRY (sex determining region Y)-box 219993_at Sox17 -1.716 0.010 17 212884_x_at Apoe apolipoprotein E -1.723 0.001 , gamma 2, smooth muscle, 202274_at Actg2 -1.739 0.035 enteric 206245_s_at Ivns1abp influenza virus NS1A binding protein -1.756 0.021 217732_s_at Itm2b integral membrane protein 2B -1.771 0.011 ATPase, Na+/K+ transporting, beta 1 201243_s_at Atp1b1 -1.783 0.012 polypeptide 212867_at Ncoa2 nuclear receptor coactivator 2 -1.787 0.027 OTTHUMG000 213158_at 00175755 /// NULL /// NULL -1.790 0.035 RP11-553L6.5 217202_s_at Glul glutamate-ammonia ligase -1.791 0.009 210298_x_at Fhl1 four and a half LIM domains 1 -1.882 0.005 203140_at Bcl6 B-cell CLL/lymphoma 6 -1.896 0.006 213649_at Srsf7 serine/arginine-rich splicing factor 7 -1.900 0.001 214500_at H2afy H2A histone family, member Y -1.904 0.025 spermidine/spermine N1- 210592_s_at Sat1 -1.985 0.013 acetyltransferase 1 201841_s_at Hspb1 heat shock 27kDa protein 1 -2.056 0.009 205366_s_at Hoxb6 homeobox B6 -2.077 0.007 201539_s_at Fhl1 four and a half LIM domains 1 -2.327 0.006 ATPase, Na+/K+ transporting, beta 1 201242_s_at Atp1b1 -4.074 0.000 polypeptide