The Annual Report as App for the iPad Research, Development and selected events at the IPHT were supported by:

Prof. Dr. Jürgen Popp // Scientific Director Frank Sondermann // Administrative Director

Dear readers,

» this annual report appears in a Just as in the past, this report In all of these years, IPHT has been new look: In addition to the printed provides you with an overview of able to count on a few crucial con- edition, which presents selected the current research and strategic stants: the willingness and capability highlights from the past year in the developments taking place at IPHT. of the scientific council, the board of HORIZON 2020 form of a magazine, this entire report The successes reported on here would trustees, and its members to act in – including detailed contributions on not have been possible without the an advisory capacity, as well as the current research and additional video continual support of the Free State of awesome dedication of its employees material – will appear for the first Thuringia and the federal government. to continue on this path together. Very time as an iOS app for the iPad We would like to take this opportu- special thanks go out to all of these (further formats will follow). As usual, nity to extend our appreciation. Many persons and committees. all content can, of course, be down- thanks as well to all of our partners loaded as a PDF from our website with whom we have collaborated www.ipht-jena.de. Using these differ- closely and on a strong basis of trust Prof. Dr. Jürgen Popp ent distribution channels, our goal is on research projects and in work- Scientific Director to reach a wider audience, regardless groups and networks. of the preferred reading habits of each Frank Sondermann individual. We have also for the first Since its founding, IPHT has been Administrative Director time published two separate versions in a continuous state of flux, always – one in German and one in English. developing and sharpening its profile. 22 | IPHT in Outer Space Content IPHT’s thermoelectric sensor is one Spot our of many components on the Philae lander, which was sent into outer 05 | Annual Report as App space as part of the ESA’s Rosetta Annual Report as App! 06 | Annual Review mission in 2004. In 2014 he landed on the Chury comet. There, he is 08 | Optical Medical Technology – Jürgen Popp in a discus- supposed to perform noncontact » The IPHT app for the iPad is directly available at the App Store. In addi- This symbol refers to addi- sion with Michael Bauer temperature measurements of the tion to the content of the printed version the user friendly app contains current tional information (for example comet’s surface – within a tenth of scientific contributions from the research areas of Biophotonic, Fiber Optics and scientific contributions on the 12 | Infection Diagnostics a Kelvin. Photonic Detection. The textual content is made up by multimedial features and subject or videos) in the app. 16 | Raman4clinics a detailed appendix including the entire publication list of the IPHT. Moreover 17 | Medicars – A Compact the integrated news feed informs about the latest reports and press releases. Microscope Used in Medical The app running on other devices will be launched soon. Diagnostics 18 | Fiber-based Spectroscopy – A Key to the Individual Treatment of Vascular Disease 22 | IPHT in Outer Space 26 | Micro and Nanotechnolo- gies from the Cleanroom 28 | Shaping the Future of En- ergy with Light 08 | Optical Medical Technology – Jürgen Popp in a discussion 32 | Scientific Contributions in with Michael Bauer the App 34 | Equal Opportunity Prof. Dr. Jürgen Popp, scientific director of IPHT, and Prof. Dr. Michael Bauer, assistant director of anesthesiology and intensive care at the 35 | Awareness of Reconciling Family and Work University Hospital of Jena, have been working together for many years in the field of biophotonics with a focus on optical medical technology. They 36 | Excellent Young Scientists met at the University Hospital of Jena to take stock of the present and 38 | 24. International Confer- discuss the future of biophotonics. ence on Raman Spektros- copy

40 | Regionally Rooted – Inter- 18 | Fiber-based Spectros- nationally Connected copy – A Key to the Indi- 42 | Key Figures 2014 vidual Treatment of Vascular Disease 44 | IPHT Celebrates the Inter- national Year of Light Fiber optics and biophotonics are Installation Manual: 46 | Organization Chart two of three main research areas 1. Open the App Store on 46 | Research Units at IPHT. To optimize the in-vivo your iPad. diagnosis and treatment of cardio- 47 | Scientific Advisory Board 2. Enter „IPHT“ to the vascular disease, male and female search box and pick the 48 | Members of the Conven- scientists at IPHT have combined IPHT app out of the hit tion their know-how in these research list. 49 | Budget of the Institute focuses. An exciting project in 3. Click „load“ to activate 50 | Staff of the Institute which a range of limits are ex- the automatic installation ceeded. process. 51 | Imprint ------6 _Journal project, mainly focusingproject, there on five years. IPHT is participating in the provide and cleara visionfornextthe the group wasto set concrete goals started in2014. The first main task of Monitoring,Therapy” and officially “Medical Engineering: Diagnostics, researchalliance coordinated by IPHT, in the planning stages. The Leibniz or are up areects setcurrently being intensified newand collaborative proj with other Leibniz institutes has been collaboration scientific existing work: as well as from the large Leibniz net reputation of theLeibniz association Christoph Matschie at the IPHT.MatschieatChristoph EU-Commissioner Johannes Hahn (in the middle) along with the Thuringian Ministers Uwe Höhn and » tional researchcommunity. ter visibilitywithinthenationalandinterna ciation. Sincejoining,IPHThasenjoyedbet taken itsplaceamongtheranksofAsso sociation formorethanayearnowandhas IPHT hasbeenamemberoftheLeibnizAs Annual Review

IPHT profits IPHT from the excellent - - - researchprojects, to effectivelyutilize these actions areto nationalcombine nating twoCOST The actions. goals of At the European level, is IPHT coordi transfer. fundamental research to industrial to coverentirethe value chainfrom gether partners, with its intendsIPHT field of opticalmedical technology.To within theresearch communityin the centralitself asa to establish figure compatible with IPHT’sstrategic goal timodal Imaging”.These activities are “Point-of-Care Diagnostics” and “Mul- search performed by the workgroups »

------Jena Centertheand Abbe of Photon the Friedrich Schiller University of hostedby IPHTin cooperation with on Raman Spectroscopy (ICORS2014) The 24th International Conference sepsis. dementia, and sis, as, forexample, cancer, arteriosclero theof clinicaldiagnosis diseasessuch Raman-based technologies for usein vancement ofresearch the in field of thecountries aread workingon scientists fromtwenty-two European source. In Raman4Clinics, research is to create energynever-ending a the in laboratory.principle The goal targeted structures toimitate this splittinginduced of water create and institutes to examine thelight- approximately 100 European research combinestH2O” competencies from experts. The COST action “Perspec createdfor research applications and cific subject-related networks be will ingnetworks. Within four years,spe - financial resources, and to build last knowledge, technical equipment, and the existingEuropean-wide source of Kick-off InternationalYear ofLights - - - - - zation of the InternationalCongress IPHT is currently assisting in organi- Activein the organization of events, of ICORS. tory largest symposium in the 48-year his 47the countries,conference wasthe With more than 925 participants from leading role this research in field. twenty yearsis evidence of IPHT’s ence Germany in for the first time in to organize theinternational confer of 2014.The fact that it waspossible Jenaicsin was oneof thehighlights in the federalin youth forscht“. competition„Jugend LuckyThe teamwinner: by supervised the gotIPHT the firstplace Ages Middle experiencedand unforgettablean evening minnesongs. jugglers and with knights, the Dinner during XXIV.Gala International Conference Ramanon Spectroscopy at the historic marketplace Jena: 1.000 madeguests a time travel to the - - and optimal working conditionsand at The excellent research infrastructure Sparkassen-Arena. 2,700delighted visitors theat Jena the city-operated company JenaKultur, Precision and OpticsEngineering and the Fraunhofer Institute for Applied nizedby IPHTin cooperation with orga Year was the which ofLight, Year ofTheLight. opening event of activities partas of the International Florence,several in well as as on Biophotonics 2015 (ICOB2015) medal for theirpatent of solar cells tissues. on Duringtheinventor iENA fair IPHTscientists were awarded withthe bronze - mobility ofmobility research scientists. researchan areato and improve the sion serve to promote Europe joint a byestablished the European Commis at IPHT. The Marie-Curie measures toresearch scientists for their stay stipendswere Marie-Curie awarded petitive EU application process, two example, aspart of thehighly-com - came to theinstitute toresearch. For abroad. This past year, 24 scientists scientists,visiting domestic from and attractiveness of theinstitute among formbasistheIPHT forincreasingthe pages 40 to 50. pages 40to50. statistics couldbefound on current keyfigures and staff the organizational structure, Detailed information about + Appendix including the list ofpublications ------7 _Journal ------8 _Journal discussion with Michael Bauer discussion withMichael Bauer JürgenPoppina Optical Medical Technology – biophotonics. discuss thefuture of of thepresentand of Jenatotakestock University Hospital They metatthe medical technology. a focusonoptical biophotonics with years inthefieldof together formany have beenworking Hospital ofJena, at theUniversity and intensivecare of anesthesiology assistant director Michael Bauer, and Prof.Dr. director ofIPHT, Popp, scientific Prof. Dr.Jürgen

» ------9 _Journal ------10 _Journal preparethem for use. clinical seek to develop state-of-the-artmicroscopic spectroscopicand methods and We arenow to able stepone go further. In closecollaboration withdoctors, we tissuemarkertion from quickly bodily and and fluids free. way; with the help of light, we can obtain biochemical and molecular informa - Biophotonicsrecord can monitor non-contact celland conditionsa in gently and diagnosis treatmentand of the aforementionedmedical diseases. the course of thepast ten years.They have thepotential to add value to the Jürgen Popp: more quicklyprecisely and treat diseases. reliable results; however, we doctors require more exact diagnostic methods to is often timesensitive.The standard diagnosticmethods to used dateprovide In the treatmenttient. addition, ofinfectious serious diseases, such as sepsis, influenced by many factors that differ inrange depending on the individual pa- continues to rise. These diseases are highly complex, theirand course is often such as cardiovascular disease,respiratory dementia, diseases,diabetes, and Bauer: Michael play amoresignificantroleintheyearstocome.Why? »

Prof. Bauer,Popp,optically-basedmedicaltechnologywill Biophotonic technologies have been continuously developed over Theoccurrence ofboth age-related widespread and diseases, is important is important for doctors to know in cal compositionofThis the deposits. wereceive information the on chemi With of thehelp Raman spectroscopy, canlead to heart a attack or stroke. If “arterial buildup” continues, this cellsinner arterialthe walls. collect on madeof rosis,plaque deposits fat and the arteries. In arteriosclein plaque solution for the exactidentification of Forexample, we discoveredoptical an search solutions tomedicalproblems. technology,medical torewell as as biophotonics and, inparticular, optical strengthpersonnel as topromote ogy. Wetechnicalthis use can as well technology,micro/nanotechnol and technology,photonic detection,system the fieldsof nologicalbasisin fiber excellentknow-how an tech and Jürgen Popp: achieve thisatIPHT? Prof. Popp,areyouableto At IPHT Atwehave IPHT the - - - - - ultimately validated foreveryday clini- an application-orientedmanner and laboratory prototypes can be tested in bySecond, collaboratingtogether, together.weighed and identified be Existing needs and challenges have to of the technologicalpossibilities. time, same doctorsbe aware should to know how doctors Atwork. the itisimportant forFirst, scientists Bauer: Michael technology? in thefieldofopticalmedical many yearssoclosetogether have youbeenworkingforso Prof. Bauer,Popp,why medical problems. molecularlevel provides solutions to the of and genesis diseases at the to better understand cell processes technologiesmethods and imaging theAlso development ofimproved fromjust few a dropsof blood. tion for appropriate treatment quickly toused therequired obtain informa a miniature laboratory which can be researchour development and workis biophotonic able The solution. goal of partners throughoutEurope on suit a Jena University Hospital and research group of Prof. Bauer (CSCC) at the the with We working are currently is anotherexample.good Sepsis during endoscopic examination. edge of operation the tumor during or mal changes and evenrecognize the healthy tissue the onsetand of abnor in a position to distinguish between dardizedtechniques, doctors willbe thehelp of Withlight. these stan- and characterizing cancertissue with standardtechniques foridentifying We areresearching anddeveloping Cancersufficient. is another example. Inmany treatment cases, drug is needs tobe treated by setting stents. Not all plaque is life threatening and order toinitiate treatment. individual For many reasons: - - - University Hospital in Jena (e.g., in laborationbetween the the IPHT and long tradition a of successful col Bauer: Michael opment of new imaging methods. fastpoint-of-care tests the develand theresearchon developmentand of network, IPHTconcentrates primarily entire innovation chain. As part of this laboratory equipment, spanning the researchtal to the development of comprehensive from– fundamen in “Optical Medical Technology” is fields. The range of research covered pertise fromof anynumber different tion, we can take advantage of ex year. As part of the Leibniz Associa- Therapy”and was initiated this past Engineering: Diagnostics, Monitoring, the Leibniz research alliance “Medical researchary approach aswell. Thus, the medical field, but an interdisciplin- requires collaboration withpartners in only not technology medical Optical and the training of technical experts. young male and female researchers especially concerning the supportof guarantees self-sustaining research – of a technology. The close interaction rectlyintothe further development users end can beintegrated di Jürgen Popp: allows appropriate adjustments. cal use. This because isimportant it Feedback from clinical In addition, thereis Inaddition, - - - - - focus at IPHT.focusat technologycal strategic asa research our todecision optical establish medi centraltopics withfuturea fortified photonicsoptics and as identified all federal havegovernment, theand EU Thuringian state government, the competitiveness.The fact that the termsespeciallyin ofincreasing lasting development, positive, and within biophotonics is an important, profile. ofThis sharpening profile our deepens ourexistingand research technology is parta of biophotonics photonic detection. Optical medical focuses:biophotonics, optics,fiber and around the threemain research researchdevelopment revolves and ences,medicine. The and focus of our areas oflife and environmental sci- solutions toproblems specific to the areresearching customizedoptical forLife” “Photonics at IPHT, we Jürgen Popp: in thefuture? medical technologyplayatIPHT Prof. Popp,whatrolewilloptical diagnostics. pathogen foodor acuteinfections, such as tuberculosis, inexpensive and on-site analysis of are developingsolutions forthe fast campus).More than thirtypartners part of the InfectoGnosticsresearch researchsepsis theCSCC within or as As part As of our motto ------11 _Journal ------12 _Journal Infection Diagnostics countries arethe working developon research scientists from sixEuropean partAs of projectthe EU HemoSpec, reliably and sepsis. diagnose the patient, it is important to quickly To given. is antibiotic treat effectively sepsis is suspected, broad-spectrum a patient’s chances of survival.Thus, if of effective antibiotics worsens the passeswithout the administration at least Every 24hours. hour that analysis,such blood as a culture, after potential isprovided via biochemicala pathogengering resistance its and »

Reliableinformation the on trig

© Lukiyanova Natalia/frenta/Shutterstock.com - - a diagnosissofar. heavily on theirexperience when making rious diseases.Doctors,therefore,rely breathing can alsobesignsofotherse- andrapidclear. Fever,increased pulse, The symptoms ofsepsisarenot always cause aseriousmultiple organ failure. gans in ashortamount oftime whichcan an infection thatspreadstoalltheor- entire body.Theorganism responds with spread throughthebloodstream tothe cases, thepathogensand theirtoxins disease toitsorigin; however,in some Normally, thebodyisabletorestrict infection causedbybacteria. Sepsis begins withalocalized has infection, morean leukocytes are body. the in viruses, If and body the foreign organisms, such bacteriaas blood cells (i.e., leukocytes). They fight biochemicalinformation whiteon Neugebauer ismolecularseeking and With of thehelp Raman spectroscopy, to is designed combine. that unit this searching oneof threekey technologies she isre light, Using this project. in Control and Care (CSCC) is participating Centerthetist at and IPHT for Sepsis Dr. Ute Neugebauer, researcha scien these medical needs. ment of miniaturea laboratory to meet - » -

Hercolleagues at are IPHT working leukocytes,” Dr. said Neugebauer. based the on activation state of the thepatient is suffering from sepsis outif wefind can determine whether of Raman spectroscopy. Our goal is to recognizethis difference help the with deactivated leukocytes. “We want to Thus, activatedleukocytes differ from messengers. orchemical as antibodies release and of such certainmolecules, cytosis(devouring) or theproduction harmless, for example, throughphago - to begin and render these intruders detectpathogen,they are a activated present the in blood. If the leukocytes

------13 _Journal // Biophotonics_ Photonic Detection ------14 _Journal DielectrophoresisRaman setup preparationsSample frompatientssamples Urin The fundamentaltechnology wasre for targeted treatment. nation ofpathogens thusthebasis and basis forthe fastpositive determiand database for fewa yearsnow. It the is ofhave Jena this workingon been at(IPC) the Friedrich Schiller University the Chemistry Institute ofPhysical and femaleMale and scientists from IPHT relevant pathogens is time consuming. base of culprits” with the spectra of fingerprint. Thus, compiling a “data- is very individual, much like a person’s tion step. ofThe spectrum pathogen a theneed for time-consuminga cultiva- – directlybodilyin fluids and without cellsbut diseasepathogenson as well biochemical information on white blood onlypossible to molecular obtain and RamanUsing spectroscopy, itisnot University Hospital. patientseighty with at Jena run being The first clinicalstudies are currently that itmeets clinical requirements. working closely withdoctorsto ensure Therefore, nurses. the scientists are can be operated by both doctors and be handy user and friendly so that it Thehours. miniature laboratory should a few dropsof blood within a few reliableobtain information from just bepossible ittoshould unit, a single By combining thesetechnologiesin controls everything. the and development of software that Ramanfluorescencethe and analysis, velopment of modules for miniaturized of fluorescence-basedmethods,the de biomarkers the in blood with the help partners, who arereading workingon performed by the European project are supplementedby theresearch theplatform.Theseon elements to separate distributeand theblood countthe cells microfluidic and a chip laboratory: holographic microscopy to otheron of elements theminiature - - - within a little more than half an hour. pathogens Raman using spectroscopy to theidentify subsequently collected phoresis) microstructured in regions (dielectroelectric fields using chip a scientists capture thepathogens on and directly from patient material. The nificantlyless than twenty-fourhours) pathogens more much quicklysig (in that makes itpossible to detect group developed innovativean method Raman setup, the youngresearchers’ With combined dielectrophoresisa treatment isbound to fail. ofincreasing resistances, this form of However,possible.quickly as time at a often tobegun counter theinfection as is antibiotics with treatment calculated twenty-four hours. In thistime, standarding methods takes atleast their sensitivity to antibioticsus the identification of pathogens and pathogens. In medical microbiology, bauer focuses tracturinary on infection groupers’ headed by Ute Neuge research at IPHT. The young research- to antibioticsimportantis an areaof pathogens, theof subject resistances In toaddition theidentification of ofability the Particle Bio Explorer. ization toand optimizethemanage qualityreproducibility and of character - is workingrap.ID with to improve the matter of a few hours. Presently, IPHT pathogensbe detected can a within to database,isolated criminal thea samples withthe database,similar contaminated.By comparingthese water or and are air samples samples many patients’ bloodgerms urine and ifand so, with which and withhow Explorer identifies whether or not, cal analysis method, the Particle Bio in combinationand with statistia - spectroscopic measurement method commercialuse. With of thehelp a developedtechnologythis further for Thecompany Berlin-based IPC. ­rap.ID searchedby IPHTin collaboration with - - - - -

sooner with antibiotics can be started much enterococci.Patient-specific treatment was verified with Vancomycin-resistant antibiotics within just 3.5 hours. This informationresistancespossible on to an antibiogram, this method provides resistances. thepreparationUnlike of existing to about draw conclusions using this method,itispossible From theRaman spectra obtained between the twomonitored.is then toapplied the chip.The interaction wereincubated with antibiotics are In seconda step, thepathogens that R and forensics. cine, art,archaeology, geology, ferent fields, including medi- spectroscopy isusedin verydif- unique asafingerprint. Raman gas) under examination isas the sample(solid,liquid, or Raman spectrum gained from winner SirC.V.Raman. The dian physicistand Nobel Prize which isnamed after theIn is basedon theRaman effect, characterization. Thismethod analysis method formaterial . a non-contact, optical a non-contact, optical aman spectroscopyis + Corporate filmHemoSpec ------15 _Journal // Biophotonics_ Photonic Detection Raman4clinics Medicars – Epithelium A Compact Microscope Used in Medical Diagnostics Fat tissues » Differentiating between healthy without staining the samples. This tural, and functional information about and malignant tissue (e.g., in cancer) allows diseased tissue to be precisely the tissue. is an integral part of medical diagnos- localized and removed in a targeted tics. To distinguish between cancer manner. Unlike with staining, the To gain clinically relevant information and altered, benign tissue, a sample multimodal images can be produced during an operation, the Medicars of the tissue is removed during opera- within a matter of minutes. microscope was developed in such a tion, stained, and evaluated under the way that its total footprint, includ- Connective tissues microscope. The technological basis of the Medi- ing its controls and laser, is suitable cars microscope is an imaging method for the operating room and that the As part of a project funded by the known as coherent anti-Stokes Raman unit can be operated by non-expert Federal Ministry of Education and spectroscopy (CARS), which utilizes personnel trained in its use. The goal Muscle tissues

_Journal Research (BMBF), research scientists the lipid content of epithelial tissue, is to improve patient care, especially Optics Fiber Biophotonics_ _Journal // at IPHT designed a compact micro- connective tissue, and fatty tissue, for during surgical treatment. Medicars 16 17 ------scope together with partners from the example, to distinguish between the has been explored and developed ------Technical University of Dresden, the different types of tissue. In addition within the research focuses bio- University of Heidelberg, the Univer- to this method, two other contrast photonics and fiber optics. The new sity of Stuttgart, the University of mechanisms are used (i.e., two-pho- photonic process has been researched Konstanz, and the Institute of Applied ton fluorescence (TPF) microscopy and and developed within the research Physics in Jena. With this microscope, second harmonic generation (SHG)). focuses biophotonics and photonics doctors can produce high-resolution All three contrast methods combined detection. multimodal images of tissue samples provide doctors with chemical, struc-

Blood vessels

» Since the fall of 2014, IPHT has financial resources and building long- scientists, raman-based applications been coordinating the European COST lasting international networks. will be further developed for clinical Action “Raman4clinics – Raman- diagnostics within the next four years. based applications for clinical di- “Raman4clinics” provides a frame- IPHT will mainly contribute to the agnostics.” COST Actions focus on work for the tasks covered by the research and development of infection bundling national research projects participating national research groups diagnostics and histopathology. Fur-

into concentrated actions on different from 21 European countries. Within ther topics of research are fiber optic Medicars has been topics and thus effectively using the conferences, summer school programs, endoscopy, cytopathology for cancel tested applica- tion orientated in European-wide existing capacity of workshops, and exchange programs cell monitoring, and therapeutic moni- cooperation with knowledge, technical equipment, and for the male and female research toring of antibiotics in body fluids. Prof. Dr. Orlando Guntinas-Lichius at the Department of Otolaryngology in Tissue of throat area Jena. Fiber-based Spectroscopy – A Key to the Individual Treatment of Vascular Disease

Cross section of a Raman probe developed at IPHT _Journal Optics_ Biophotonics Fiber _Journal //

18 19 ------

Fiber optics and biophotonics are two of three main research ar- eas at IPHT. To optimize the in vivo diagnosis and treatment of cardiovascular disease, male and female scientists at IPHT have combined their know-how in these research focuses. An exciting project in which many challenges have been tackled. » ------20 _Journal composition of theplaque wouldhelp composition.Better knowledge of the treated theirbiochemicaldepends on If howand the mustdeposits be plaque. called deposits, up build progressive disease,the arterial walls industrialnations. Inthischronically common causesof western deathin heart attackmost arethe – among its consequencesand – stroke and greatis because arteriosclerosis The medicalneed for such studya composition ofplaque. precisely and determinethe chemical withhim the idea wasborn to quickly TogetherBrehm wasestablished. the cardiologist Professor Dr. Bernhard is coordinatedby IPHT,the contactto for Biophotonics Photonics4life, which thein European Network of Excellence Popp,scientific director at IPHT. With - arteriosclerosis,” says Prof. Dr. Jürgen the treatmentin diagnosis and of features to optimizethe existing gap idea was to combineboth of these formation fast contract and free.“The molecularobtain biochemicaland in scattering by light molecules, one can example, measurement signals. From informationdatafor suchas, and pledinto optical fibers,it cantransmit Raman probe » Light is a specialtool.is couLighta When - - because the probe head isinflexible yetsuited for human application The fiber-spectroscopic probe isnot Matthäus, researchertian at IPHT. composition of plaque,” says Dr. Chris preciseinformation themolecular on heart catheterexaminationprovides to show that theuseof light during “WeUniversity Hospital. were able cooperationin experiment withJena analysis was performed in model a guiding optical fibers, a spectroscopic Vision consisting of severallight- Withprobe a fromthe company EM moreis difficult. individualizeddiagnosis and treatment cannot Therefore, beidentified. the biochemical composition of theplaque method, themolecularwith this and dures using contrast however,agents; of help the x-rayvisible with proce ofthe coronarymade be arteries can tion,in which the form andstructure of plaqueisheart catheter examina method of established One diagnosis treatment wouldthenfollow. diagnosed. Individualizedmedical plaques able, could bemore precisely Dangerous, vulner so-called ment. makemore a accuraterisk assess - - - - - spectrum. The fibers that multi-mode spectrum. is fibers too weak to record Ramana core).The light collected withsuch mode fibers(i.e., fibers with smalla This solution only works with single- core. requiredlight is guided through the certain wavelength; thus, only the back reflected is at a light gruence, totheirstructure. defined At con the wavelengthof the coupledlight the fiber core.in The gratingsmatch structures)(periodic were inscribed Health Probe, Fiber Bragg gratings the BMBF-funded joint project Fiber cianat IPHT. Intheframework of said Dr. Martin Becker, a fiber techni- replaces the theprobe,”filters in We, therefore, needed solution that a fromnoise generatedthe the fiber.in forRaman-spectroscopic examination separate the excitationrequired light “The the filters sensorheadin requested help. tianDochow, alsoworking at IPHT, Matthäus his colleagueand Dr. Sebas forneed medical more flexible fibers, examination is too To high. meet the the delicate coronary arteries during tegrated filters.The risk of damaging at length ofa 5-6 to due cm thein - - - method for cardiovascularexamina - ence tomography (OCT) is an imaging ahead to thenext step.Optical coher scientists at IPHT are alreadythinking yet been completed, the research Although fiber optimization has not severalend. the at cores bundled and togetheris guided thelight through ofmulti-core fibers. Inthese fibers, currentlyresearching the applicability Matthäus, they are Christian und Togethertion. Dochow Sebastian with manufacturingprocess to characteriza - materials to steps all of the fiber tional level, essentially unique – from that theinternais, on equipment have at technological their disposal leagues fromthe fiberoptics group Tomanufacture colhis these fibers, a targeted manner,” says Dr. Dochow. amount of light and to filter light in that can beused to collect largea “What weneed are customized fibers targeted mannerthe in core. coupled light cannot be filtered in a with largea diameter; however, the havearethis field commonin corea - - - phy in the future.the in phy grated opticalin coherence tomogra in such a way that they canbe inte - therefore, should, fibers be developed ent excitation waves. The multi-core OCT Ramanand work with differ- Dr. Dochow. size ofand theplaque said as well,” devicebut information the on shape chemicalinformation with single a it idealwouldbe to not obtain only withthe arterial walls.“For doctors, with scatteredlight thatinteracts tion. Similar to Raman, OCT works - T and liquids. explosives, drugs,medicine, uses, suchastheanalysisof fields includenon-medical Other possibleapplication analyze thesignalsobtained. which tissueandhowto optical fibersaresuitedfor is alsoinvestigatingwhich the UniversityofJena,IPHT Physical Chemistry(IPC)at tumors. WiththeInstituteof colon cancerandbrain the molecularanalysisof Jena UniversityHospital, with theircolleaguesfrom researching, incollaboration scientists atIPHTare disease. Theresearch endoscopically accessible speaking, applicabletoeach applications butis,generally only forcardiovascular probe issuitednot he fiberopticRaman

© iStock.com/pixologicstudio ------21 _Journal // Fiber Optics_ Biophotonics IPHT in Outer Space

A sensor head approximately 10 millimeters in diameter that rests on five legs and contains a 3.6 mm x 3.6 mm large chip. _Journal Detection Photonic _Journal //

22 It is hard to believe that such a small component can be used 23 ------to ­perform non-contact temperature measurements (e. g., the ­surface temperature of the Chury comet) accurately to within a tenth of a Kelvin. IPHT’s thermoelectric sensor is one of many components on the Philae lander, which was sent into outer space as part of the ESA’s Rosetta mission in 2004 and landed on the Chury comet in 2014. »

DLR DLR

Philae touchdown Philae all instruments Further space ­missions in which IPHT is currently Even today, IPHT is in the unique Due to these numerous projects, Ernst participating position to develop and manufacture Kessler’s group has received an inter- thermoelectric sensors with the high- national reputation. Also, Dr. Kessler est detectivity worldwide. In addition, is a co-investigator for NASA and thus ESA’s BepiColombo sensors at IPHT can be customized a member of an international team of Mission­ and developed – even in quantities experts. of one. Goal: Measure the mineralo- Nevertheless, the question continues gical composition and tempe- Currently, Ernst Kessler and his col- to be raised as to whether the sen- rature of Mercury’s surface. leagues are working on a new and sors developed 20 years ago remain Start: ­expected in 2016 exciting space project. This time it contemporary. Dr. Kessler affirms does not deal at all with temperature this view: “This type of detector was measurement but rather with orbital developed for space conditions that Jaxa Mission Hayabusa debris and space junk, for example still exist today and applications that the remains of abandoned satellites are still used today and thus do not Goal: Collect information on or the debris from satellite collisions require optimization. I know that the surface temperature and and explosions. According to infor- is tough to believe in a time when the surface mineralogy of the mation from NASA, almost 500,000 higher, faster, farther is the defining asteroid. particles that are larger than one goal. But, we simply got it right the Start: The probe has been in centimeter in diameter are in orbit first time.” around the earth. The detection and space since the beginning of December 2014; it is expected _Journal measurement of these particles is Although these sensors, which have Detection Photonic _Journal // important to prevent collisions with been researched and developed within to land the middle of 2018. 24 25 ------space stations and satellites. Objects the research focus photonics detec------that are larger than five centimeters tion, are tailored for applications in NASA / ESA’s InSight are located by following their orbital outer space, they are still suited for Dr. Ernst Kessler Mission to Mars flight path from earth; however, very other application fields. For example, little is known about smaller particles. they are used to monitor the com- Goal: Collect information A thermal detector chip developed by position of anesthesia gases or to » The research scientists at IPHT’s ture measurements on the surface Spanish subsidiary of EADS – when IPHT in collaboration with the com- determine the age of airplane oil. on the surface temperature predecessor institute were not of the 67P/Churyumov-Gerasimenko they were in need of a sensor for the pany etamax space GmbH will provide Another possible field of application is and surface mineralogy of the aware that the infrared sensors they comet as part of the Rosetta mission Curiosity rover as part of the NASA information on particles that are 5-20 the exploration of deposits of natural planet. developed would one day be sent that was set to launch in March of Mars mission Mars Science Laborato- micrometers in size. resources in the earth. Start: March 2016 to outer space on a European Space 2004. A regular contact thermometer ry. “When our Spanish colleagues told Agency (ESA) launcher. “Originally, would not be able to make accurate us they performed a global search for IPHT won the bid for another NASA + current air and ground ESA-Exomars these sensors were developed for measurements because the surface a sensor developer like us, we were, project and will submit thermoelectric temperatures on Mars non-contact temperature measure- of the comet is covered in dust. The of course, proud,” said Dr. Kessler. sensors for the first round of feasibil- + background information on Goal: To establish mineralo- ments and for use in infrared spec- challenge for the IPHT research team ity studies. If IPHT’s sensors make DLR space missions trometers produced by the company was not only to develop a robust the final cut, then they will presum- gical composition and identify Carl Zeiss Jena,” said Dr. Ernst Kessler, sensor with high detectivity but to ably be used in the flight to Jupiter’s organic pigments hermoelectric sensors a research scientist who has been adapt it to withstand the harsh condi- Europa moon in 2022. Start: approximately 2018 convert thermal radiation working at IPHT for more than 30 tions in space. The housing, which T to electrical voltage signals. years. “However, as early as the mid- was designed at IPHT specifically for NASA-Mars2020 1970s, contributing work in the form the sensor, has a small hole through From these measurement of highly-sensitive radiation detectors which the air escapes upon passage signals, the temperature of the Goal: To acquiring informa- was performed for Soviet missions to from the earth’s atmosphere into radiation source can be deter- tion about Martian geology, Venus.” outer space. In the vacuum created, mined. A regular contact ther- atmosphere, environmental the sensor achieves its highest ther- mometer would not be able Thus, it was not a coincidence that mal sensitivity. conditions, and potential bio- to provide reliable measure- the German Aerospace Center (DLR) signatures ments on the comet because requested IPHT specifically to develop Almost 15 years later, IPHT gained Start: 2020 a sensor for non-contact tempera- the attention of Astrium Crisa – a the surface is covered in dust.

1 The Threat of Orbital Debris and Protecting NASA Space Assets from Satellite Collisions (2009) ------26 _Journal technologies has been certified according to ISO since 2002. is of strategicimportance to IPHT.The management quality ofbasic important Fraunhoferthe neighboring Institute of Optics Fine Applied and Mechanics (IOF) erationline. Direct access to the state-of-the-art electronbeam coating facility at wafer formats of up to inches. 6 In addition, operatesIPHT its own mask gen control, micro nanoscaleand functional structures can bereliably produced on 1,500 squaremeters. Thanks to the excellent cleanroom conditions climateand Thecleanroom extends acrosssurfacetwo a floors and areaof approximately bottom-up techniques (nanoparticles, nanowires, molecular techniques) at IPHT. synergistically combinetop-down techniques (micro nanolithography)and with nanostructures and 3-D functional elements. The cleanroom makes it possible to that with the technologicalis well equipped infrastructure necessary toproduce tems. For this purpose, IPHT has a state-of-the-art cleanroom on its premises example, theirand systemic integration into ultrasensitive measurement sys form thebasis for the technical ofimplementation photonic sensor concepts, for nanotechnologies.Based targeted on fundamentalresearch, these technologies velopment maintenanceand of a comprehensive pool of intertwining micro and » fromIPHT’s Cleanroom Nanotechnologies and Micro Photolithographyat IPHT’scleanroom The successful ofimplementation research IPHT’s objectivesrequires the de + Scientificcontribution“E-beam withCharacterProjection:APowerfulTool + Cleanroomvideo for Wafer-scaleNanolithography” for

- - - deposition sputteringdeposition and techniques. the wafer’ssurface in a vacuum using vapor Coating I: layers.dielectric ­structures aretransferred to metallic and Dry Etching: With beams ion or plasmas, is available. (ALD) layer layers, atomic deposition dielectric extremely thin,low-defect, surface-conform Etching: ALD /Dry precious-metal films. produce complex layer systems plasmonic and vapor are equipment todeposition used withup to twelve targets andhigh-vacuum Coating II: Metallicthinfilms are appliedto A three-chamber sputter cluster three-chamber A For the fabrication of 2nd Level 1st Level cleanroom. preventhuman-related contamination of the Airlock: Employeesuse special clothing to micrometers size.in patternssmallest mask’s are approximatelytwo technical components –using UV The light. coated wafer – the basic platform for micro resista isproduced mask) on photoresist-a (i. e., structure defined Photolithography: A (electron beam). range of 0.8 theproduction of even finer the structuresin using lasera or electron beam. This allows In this method, the resist layer isilluminated Electron and Laser Beam Lithography: scope atomic and force microscopy (AFM). nanostructuresusing a scanning electronmicro - ProcessNanoanalytics: and quality control of chemical silicon etchingprocesses. for sensors THz are based our IR and on wet structuredmembranes in a cantilever design WetChemistry I+ II: technology. laboratory a in for connection assembly and special carriers integratedand into housings of waferchips a individual theto arebonded AVT Laboratory: Forsystem applications, processes. produced via chemical vapor deposition(CVD) ­layersystems applicationsfor areMEMS LPCVD: Dielectricthinfilms membrane and for sensor technology.IR Coating III: µm (laser beam) and 0.03 Production oflayermetal systems MEMS technologiesMEMS with µm ------27 _Journal // Photonic Detection Fossil fuels are finite, and yet, approxi- mately 86 percent of the energy being Shaping the Future used still originates from oil, gas, or coal. of Energy with Light In light of increasing commodity prices and considering the shortage in supply, this is still too high. To avert the impend- ing energy crisis, inexpensive and renew- able sources of energy must be developed _Journal Detection Photonic _Journal //

28 and used. » 29 ------

» Hydrogen is considered the energy This is the starting point of the work source of the future. Because hydro- of Prof. Dr. Benjamin Dietzek, a re- gen is a component of water, it is searcher at IPHT. available in large quantities. When it is burned, it produces water again. Within the research focus photonics detection, he and his male and female One approach to gaining hydrogen is colleagues are trying to understand photocatalytic water splitting. With the details of the steps that take the help of light, water is split into place at the molecular level in novel its components hydrogen and oxygen. molecular photocatalysts. For this pur- This process imitates the biochemi- pose, a light-absorbing center (here, a cal process that plants practice on a dye) is linked to a reaction center. The large scale – photosynthesis, thus the reaction center can be a coordinated conversion of light to chemical energy. metal ion, a metallic nanoparticle, or a semiconductor surface. Hydrogen is In 1972, this process was discovered created at the interface between the by the Japanese chemists Akira Fu- reaction center and the surrounding jishima and Kenichi Honda. Since that aqueous solution. time, scientists have been looking for a way to use photocatalytic water “We are particularly interested in the splitting for industrial applications. transfer of electrons to the reaction They have been only moderately suc- center. This step occurs within a cessful because these methods are millionth of a millionth of a second,” not yet efficient enough. says Dietzek. With the help of time------30 _Journal optimize theprocess. tor material order in to know how to between the dye the semiconducand basic transfer steps of the electrons it is necessaryalso to understand the had low a degree of efficiency.Here, Thesecontact. solar cells have always semiconductorreach and solarcell a that areset freeleave the dye viathe photoactive a electrode.The electrons semiconductor, a whichtogether form absorbedby a thin dye-filmlocated on cells. In type this ofis solar light cell, researchis objectdye-sensitizedsolar layers,” says Dietzek. One current interaction occurs boundary at solid molecular a which in processes study interfacesFor as well. reason,this we water splittingbut in the functional photocatalytic in processes molecular “We are not only interested in the of electrons. these changeshave the on transfer Dietzekmin can findout whicheffect connectionbetween the two),Benja nature of thereaction center, or the (e.g., the structure of the dye, the By changing individual parameters efficient the generation ofhydrogen. themorepart of spectrum, the sun lystsbecause thelarger the absorbed ofcata the efficiency the can affect pates Thisthe in ofabsorption light. unit in which spectral range partici- the molecule light or absorbs which Dietzek canresearch whichsubunit of With resonance Raman spectroscopy, electrons can berecorded. thus, the timescale of the transfer of movementof atomsindividual and, fast camera. Withthis camera,the second) form thebasis ofultra an (i.e., 30 billionths of a millionth of a approximately30 femtoseconds the transfer: Lightthat pulses last resolved spectroscopy, he can image - - - - Characterization of miniaturizeda solarpanel layer.This solar fabrichas the special tected by a highly-transparent silicon These modules modules. are pro into it and processed them into mini withmetal contact wires woven layerson Vitrulan’soptical fiber fabric thin-film silicon solar cellsin several researchpreparedscientists at IPHT Tomanufacture the solar fabric, the consumption,” said Dr. Plentz. large a portion of the entire energy electrical devices that now represent self-sufficient energy supply for small orcurtains, tents,it could serve as a ible. Whenintegrated into clothing, byoped usis extremely light and flex fiber fabric.“The solar fabric devel- technology of solar cells optical on an material basis and manufacturing colleagues, hehas researched the Togethermale female and his with researchsolarcells. is also at IPHT The topic ofDr. JonathanPlentz’ Energy Supply Self-sufficient Solar Fabricfora - - Solar fabric the fabricto achieve this goal. thereproducibility of the solar cells on colleagueshis liketo would increase phone. In a next step, Dr. Plentz and topower smart fora example, ficient, that is 8 cm x 14 cm in size is suf piece A of Plentz. said solar fabric piecescut out arbitrarily afterwards,” be produced panels like in cloth and trial level possible. “The fabric could inexpensive production at the indus voltage requirements. This makes later pointpoweron depending and connectedbe at assembled a can and feature that the solar cellsapplied Cells onTextiles” + Scientificcontribution“Solar - - - Jonathan the Plentz scrutinising coating process Benjamin Dietzek of thefuture.“ mary energysource drogen asthepri- fossil fuelswithhy goal ofreplacing contribution tothe “We aremakingour // ------31 _Journal // Photonic Detection ------32 _Journal » » » » » » Inthe app, you will findthe following contributionsonthis research topic: diagnostics. researchin the life sciences to food and environmental safety to clinical nanoparticlebased The analytics. applicationrange fields from fundamental larspectroscopy hyperspectral and imaging aswell fiber,in as chip, and methods toolsand based – on fundamentalapplied research molecu in – In the biophotonics research focus, innovative implements IPHT photonic Biophotonics intheApp Scientific Contributions Krafft // Anwar-Alebrahim // Popp Krafft // Freitag // Popp Stiebing // Matthäus // Lorkowski // Popp Stallmach // Popp Tolstik // Matthäus // Marquardt // //Galler Bauer // Popp // Neugebauer Bekele Legesse // Heuke // Schmitt // Popp //Bocklitz Dochow // // Chernavskaia Spectroscopy of Teeth using Raman and FTIR Structural and Chemical Studies Tumor Cell Detection Functionalized SERS Labels for ment of Atherosclerotic Plaques Develop Understanding the – Tracing Macrophages inside Lipids of Cancer Liver Diagnosis RamanSpectroscopy for the Spectroscopy Cells inLiver Tissue using Raman Stellate of Hepatic Identification Imaging with the Help of Multimodal Ex vivo and

in vivoin

Diagnostics

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» » » » » Müller // Stranik // Gläser // Fritzsche Csaki // Fritzsche Wirth // Garwe // Bergmann // Stranik // Jatschka // Csaki // Stranik // Fritzsche Weber // Cialla-May // Popp Kämmer // Olschewski // Bocklitz // Rösch // Weber // Cialla-May // Popp Hidi // Mühlig // Jahn // Henkel // gations Tissue forToxicitylogical Investi Transport of Nanoparticles inBio- wavelength interference layers from single nanoparticle by sub- of scattered light Manipulation Detection Resonance-based Sensors for DNA Localized Surface Plasmon SERS Measurements Reproducible Quantitative LOC- NovelA Calibration Concept for and Levofloxacin of Methotrexate Detection SERS Fast and High-throughput LOC- Towards Online Drug Monitoring:

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- » » » » » Research Experiments inEnvironmental Frosch // Jochum // Popp Deckert // Singh // Deckert-Gaudig // Zhang //Meisel Stöckel // Rösch // Popp Deckert-Gaudig // Zell // Deckert // Popp Trautmann // Cialla-May // Weber // Bocklitz // Kämmer // Stöckel // Weber // Popp Schwenkbier // Pollok // Cialla-May // scopic Analysis of Analysis scopic Cavity-enhanced Raman Spectro- Catalysis Nanoscale scopy Pathogens via Raman Spectro- ofMeat-associated Identification Methods Analysis Image and Microscopy a Combination of Atomic Force Single-Virus Detection using On-chip Hybridization Strategy gens by Employing a Powerful On-site Detection of Plant Patho-

13 CO

2 Labeling » » » » » » » contributionsresearch this on topic: Inthe app, you will findthe following rangeof applications. systems and modules for wide a guided light; it also researches fiber efficient flexible and controlof fiber- on the propagation properties and IPHT performs fundamental research Inthe fiberopticsresearch focus, Fiber Optics Zhu // Bartelt Jäger // He // Leich // Grimm// Kobelke // // Unger // Jäger // Rothhardt // Bartelt Leich // Fiebrandt // Schwuchow // Jetschke Ludwig // Schwuchow // Dellith // Bartelt Litzkendorf // Grimm// Schuster // Pochert // Wieduwilt // Schmidt Kröckel // Schmidt // Unger // Schuster Kobelke // // Bierlich Wondraczek // Ludwig raczek // // Bierlich Popp // Schmidt// Frosch //Hartung Kobelke // Schwuchow // Wond Power Rods in Fibers for Use inScaling the Pulse Large-Core REPUSIL Amplifier doped Fibers During Pumping of Temperature Effects in Yb- Length-distributed Measurement Applications Aluminosilicate Glass for Laser Yb-Doped Lanthanum/Yttrium- Sensors Use Biochemical in Fiber-basedMicroresonators for Range Water in the Ultraviolet Spectral Optical Properties of Ultrapure Complex Sensory Applications Fibers for Microstructured Guidance in the UV Novel Hollow-core Fibers for Light

- » » » » contributionsresearch this on topic: Inthe app, you will findthe following spectrally resolved detection of light. sensitive temporally, spatially, and mentation of systems for thehighly deals with the research and imple- Thephotonic detectionresearch focus Photonic Detection » » » » Riesenberg // Kanka // Grjasnow // Wuttig Plentz // Gawlik // Brückner // Andrä Andrä // Junghanns // Plentz Kessler // Hänschke // May Kröckel // Schmidt Bartelt Becker // Elsmann // Latka // Rothhardt // Spittel // Bartelt // Schmidt Jetschke // Becker // Hartung // Bartelt Leich // Jäger // Grimm// Eschrich // Working Distance graphic Microscopy withLong Self-Calibrating Lensless Holo- Solar Cells Textileson Film Solar Cells Silicon/PEDOT:PSS Hybrid Thin- Flow Segmented gregated Biological Samples in StudyofCalorimeter for Ag the Based Chip Thermopile tionFlow-Injection and a Analysis using Online Fluorescence Detec- Water in Phosphates Detecting Systems RangeComponents asforLaser Gratingsin the Visible Spectral Production of Chirped Fiber Bragg filled Photonic Crystal Fibers Plasmonic Bandgaps inMetal- PowerOutput lization at 976 nm and 10 W of Laser withWavelength Stabi- Tapered Fiber Fundamental-Mode

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» » » » » » » » » Hübner // Hübner Zeitner Paa // Stafast Karras // Litzkendorf // Grimm // Schuster // Mühlig // Bublitz Müller // Paa // Wagner // Burkert //Ilichev Oelsen Goerke// Ziegler Stolz // // Hübner Meyer Linzen // Schneider // DunkeL // Schiffler // Schultze // Meyer Scholtes // Woetzel // IJsselsteijn // Meyer Stolz // Chwala // Schiffler // Queitsch // Nanolithography A Powerful Tool for Wafer-scale E-beam with Character Projection: Glasses Refractive Index of SAL Selected Measurement ofNonlinear the tion for DUV laser forDUV tion applications Accelerateddegrada absorption Notsilica all glasses are alike– data. magnetic field methods for airborne acquired From 2D to 3D: new processing Array Detection with a Quantum Sensor Spatially Resolved Single Photon Particle-Laden Flames MeasurementsSpectroscopic of Geophysics of Focus at the FossaCarolina Large Construction Site in793: Magnetometers Pumped Optically Relaxation Processes to Optimize of Intrinsic Investigation Sensorsystemeneue AlN-Dünnschichtmembranen für

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------33 _Journal ------34 _Journal available for young,qualified female There are many long-term prospects graduatepostgraduate and studies. managementpursue roles their during tists are targeted encouraged and to achieved if female research scien managementin positions can only be increasing thepercentage of women For IPHT,means this that the goal of female candidates isnot always easy. manities.Thus, the search for suitable are more much prevalent the in hu of male colleagues. Female students altogether lower ismuch – than that of number the femalethus graduates physicsstudents in majoring – and the fact that thepercentage of female presence management in islinked to The challengeto increasing the female toreduce the deficits these in areas. already taken numbera ofmeasures reasonable ofperiod time. has IPHT achieving these objectives within a advocateis an Association and of ates the commitment of theLeibniz continuouslyincreased.appreci IPHT ment positionsmust be swiftly and percentage of women manage in In this context particular,andin the career individual tions and aspirations. womenand based their on qualifica advancement to opportunities men pursuingthe goalof providing career efforts, the Leibniz Association is » family lifearehigh-prioritytasksatIPHT. lishment ofmeasures tobalance worklifeand just inmanagement positions –and theestab- The advancement offemale scientists –not Equal Opportunityat IPHT Aspart ofits equal opportunity - - - - - minds inscience andresearch.” the mosttalented, creative,andcapable bedded inour maximtoattainandretain the LeibnizAssociation.Itisfirmly em “Equal opportunityisanintegral partof The management is committed to balancing worklife and familylife. improvementtheis of conditions for important aspectofOne thiseffort femalemanagers to be won for IPHT. targetedin a used search for suitable head positions,headhunters be will Whenrefilling vacant department leadership skills. where they acquired thenecessary scientifcresearch careersthe IPHT,at research grous started their successful results:The femaleleader of several ofhas already action positiveyielded the in Institute.This strategic course roles toand become more involved preparation in ofleadership such that precede management positions take theresponsibilities tasks on and availablenities for femalescientiststo scientists at IPHT.There areopportu Prof. Dr.Matthias Kleiner,Presidentof theLeibnizAssociation »

- Association. Association. theing standards setby theLeibniz involved inimplementing and enforc determine the needs resourcesand this workgroup made itits goal to leadership of the scientific director, initiated at IPHT. Under the personal EqualOpportunities workgroup was other measures the in future, an To optimizeexpandand these and meetingsting up and deadlines. ationof familialinterests whenset considerflexible and workinghours These resourcessponsibilities. include specific needsrelated to familial re scientists at toIPHT better meet the the way for femalemale and research using appropriate resources to pave // - - - - - Who is to going Who do the shopping What happens if somebody falls ill? tothepick children fromup school? is going be veryorganized. well Who before hours afterhave and school to until well into the afternoon. The to school where they are supervised child; duringthe day,they both go Ihave 10-year-old a 6-year-old and a well? balance workand family lifeso at IPHT.Howdoyoumanage to full-time asaresearchscientist andwork life family reconciling Awarenessof » Wächtler Interview withDr.Maria

Mrs. Wächtler,youwork to comelater in orleave earlier than working hours. I have the freedom opportunity affordedme to set flexible I definitely take advantage of the balance workandfamily life? do youtakeadvantageoftohelp What measures offeredbyIPHT tion. very considerateof my familysitua employeris who asan count on IPHT be.to InI need able addition, am outparentswhen us areto help able tion to further our careers.Luckily, our as I do, but we both have the ambi responsible forthe careof our children for Mydinner? husband feels just as - - very high. ance between work and family life is to be. At IPHT, awareness of the bal knowand how flexible one often has department heads, havealso children female colleagues, including many Very positively. Many of my male and How doyour colleaguesreact? paper forpublication. acceptable when a Iworkingon am surements to make, but itis certainly possible when I have laboratory mea work at home. Of course, that isnot usual andfinish up any outstanding ------35 _Journal Tobias Tieß Tatjana Tolstik

2007 - 2010 2005 - 2010 Bachelor of Science in Degree in Biology Physics from the State University of Minsk 2010 - 2013 Atlantis MILMI 2009 - 2010 Dual Degree Master Research Program with stays internships at the at the universities in Friedrich Schiller Orlando, FL (USA), ­ University Jena Dr. Sebastian Dochow // Award from the aser and Jena Technology Science Society since 2010 Current degree Dissertation on Master of Science in “Raman imaging Photonics and Optics spectroscopy as a new diagnostic since 2013 method for liver Dissertation on cancer“ “Tunable Fiber Lasers

_Journal based on Fiber Bragg _Journal 36 Grating Arrays” 37 ------

Tatjana Tolstik // Hermann Strauß Research Award of the DCCV 2014 Wazeem Basheer Karunnapallil // DAAD Award for excellent achievement by a foreign student at a German university » Young male and female scientists IPHT is interested in awakening the at IPHT were recognized with a se- enthusiasm of the very young for sci- ries of prizes and awards for excellent ence and research. That is why IPHT research performances this past year. participates every year at a local re- This reinforces IPHT in its effort to search day for schoolchildren in Jena. support and educate young research Together with the Friedrich Schiller scientists. Young, skilled personnel University Jena, IPHT organizes a secures a future of innovation and summer school program for science growth. minded boys and girls once a year.

Tobias Tieß // Young Researchers Award from the German Branch of the European Optical Society IPHT supports young, talented male and female research scientists at all levels of their career – from under- Dr. Maria Wächtler // Albert Weller Award, graduate studies to graduate studies German Bunsen Society for Physical Chemistry to postdoc research and gaining the qualifications necessary to take on a leadership position. In addition, young Excellent male and female researchers can take advantage of funding opportunities Young Scientists offered by the Leibniz Association.

Zhenglong Zhang // GCCD Young Researchers Award ------38 _Journal on Raman Spectroscopy 24th International Conference presented their products and currentpresented products and their more than fiftyindustrial exhibitors for the conference,During students. 400posters,several and workshops sessions, twoposter exhibitions with included 413 lectures in seventy-nine spectroscopy. The scientific program application possibilities of Raman researchresults, trends, the and Together,participantsthe discussed traveled from as farNew as Zealand. Great Britain were present. Guests from the U.S.A., India, China, and largea of number research scientists addition to participants from Germany, invitationtoJena. In continents acceptedthe seven five countries and Visitors from forty- to be a valuable host. spectroscopyproved and hubin the field ofRaman prominent international of high quality.” Jena is a cellently organized.The sessions were the best seems it’s ICORS ever.” “Ex conference:the “Itinto that went more than two years ofpreparation follows,sions as acknowledgingthe » years. in Germany forthefirsttimein twenty Abbe Center ofPhotonics, washostedagain Friedrich SchillerUniversity Jena and the organized byIPHTin cooperation withthe forty-eight yearsago.Thissix-day event, est conference sincethefirstICORSwasheld August of2014,turned outtobethelarg- Spectroscopy, whichtookplacein Jena in XXIV. International Conference on Raman With morethan925participants, the Visitors summarized theirimpres »

Conference Chair // Prof.JürgenPopp, the the IPHT,and story forJena, nice success “This isavery ­University.” - - za, Brazil, in2016. next ICORS will take place inFortale- celebration with a aftersixdays. The the conferencement,” was ended Innovative Technological Develop “Best Junior Researcher,” and “Most emony the in categories of“Lifetime,” Withthe first-everRaman award cer- toAges. trip theMiddle craftsmen accompanied visitors a on accompanying programs, including the remember the comprehensiverange of tific program, the participants will In toaddition the excellent scien developments.

+ ICORSimagefilm

musicians,historic and jesters, artists,dancers, knights, marketplace: historicthe at dinner conference wasthe gala testablehighlight of the around Jena. The incon excursionssightseeing as the city tours and welcomepartywell as

- - - Medieval Gala Dinner Get-together Laureates of Raman Awards Industry exhibition Participants during keynote lecture ------39 _Journal » Regional, national, and internation- of IPHT’s involvement in the regional Research Focus” funded by the al collaboration is extremely important photonics branch. Federal Ministry of Education and Regionally Rooted – to IPHT’s research. On the regional Research. level, IPHT works closely with Jena’s On the national level, IPHT acts as a universities. Through its participa- joint between photonics and the life IPHT is a founding member and ini- tion in the InfectoGnostics research sciences, for example, as part of the tiator of international networks such Internationally Connected campus, IPHT is also strongly rooted Leibniz Association’s research alliance as “Biophotonics4Life” and “Photonic- in Thuringia’s research landscape. “Medical Engineering: Diagnostics, s4Life.” Membership in networks such as Monitoring, and Therapy” or in its role “optonet” and “medways” is indicative as coordinator of the “Biophotonics _Journal _Journal

40 41 ------

PHT collaborates with Ipartners from 49 different countries worldwide. IPHT at a Glance – 52 % Key figures of 2014 Project funding

Participation in 891,6 T € 140 EU contracts / projects conferences 3.413,9 T € 86 Industry contracts / projects 12 Invited talks Projects funded by the EU 6.314,0 T € 5 National projects of them coordinated by IPHT 21,3 Mio € Total budget _Journal _Journal

42 87 43 ------Media reports 10.413,7 T € ------(print, tv, radio) Institutional funding

13 Patent applications 5 Patent grants

14 Doctorades 45 5 Academic 185 of them from women teaching Peer-reviewed employees publications 334 Female and male employees 44 ------_Journal Ralph Caspers. “LIGHT Phenomena” starring theWDRanchorman The opening event included ascienceshowentitled areas, severalactivitiesand events arebeing planned in Jena. light and nature aswelllightand culture. Withinthesesubject content include thefollowing: lighttechnology, lightresearch, technology companies. Thefour main pillarsin terms of with Jena’suniversities,non-university research institutes, and IPHT iscelebrating the“International YearofLight”together International Year ofLight IPHT Celebrates the T general public. based technologies among the of theimportancelight- tions –istoraiseawareness proclaimed bytheUnited Na goal oftheYearLight–as nizations andUNESCO.The nally-active scientificorga- tiative startedbyinternatio Technologies isaglobalini Light andLight-based he InternationalYearof » - - - Anchorman Ralph Casper talking to Jürgen Popp.

Laserman two-hour show of experiments also by Thuringian schoolchildren. The were submittedprior to the show formedlive stage. on The questions based exciting on per experiments “Oh!”), answeredGo questions macht Ah!”(Knowledge Makes You Starring the Mouse) “Wissen and “Sendung mit der Maus” (The Show knownis from suchshows as the Caspers, who live theinternet. on other viewers followedtheshow ing areadowntownin Jena 500 and lowed the show at public screen a out concertspectators600 folhall, to the audience of2,700 at the sold- Inaddition Development. Business ated company JenaKultur, and Jena thePrecision city-oper Engineering, Institute for Optics Applied and cooperationFraunhoferthe with Arena, was organized by IPHT in took place the in Jena Sparkassen » The ceremony,opening which - - - - Dr. Dieter Weiss (left) and Minister Wolfgang Tiefensee (right) during an experiment on stage. expected. Society, thousands of visitors are Physical German the together with organizedby theUniversity of Jena At thisevent being alone, whichis ofPhysics” “Highlights theme week. be showcasing will the itself during a keen interest in science. IPHT Thuringianhigh schools which shows addresses of sophomoresjuniors and care“. These STIFT funded training tonic – Visions for better health „Biopho sommer school a entitled bergCampus, the IPHT organizes institutes, located at the Beuten Schiller University Jena and research Together of Light. Friedrich the with placeofpart theYearJena around as taking be that will other activities IPHT will be participating in several “Feeding theFish.” Man”the andperformance group included acts by the French “Laser - - www.lichtstadt-jena.de Further Information: optics photonicsand in Jena. particular, on thelong tradition of in Jena will,therefore, focus,in tofuture The activitiesquestions. technologies from Jena solutionsas importance of optical andphotonic general publicaboutthe ized and will be informing both the special- optics.and Furthermore, IPHT the in field of science, technology, professionsacademic studies and interestof younger generations for thepating effortsin to spark the partici be actively will IPHT Light, With involvement its the in Year of + TVrecordingofthe opening ceremony

------45 _Journal Organization Chart Scientific Advisory

Assembly of Members Board of Trustees Scientific Advisory Council Council

Dr. Bernd Ebersold // Theo Tschudi // Chairman Chairman

Strategy and Communications Executive Committee Deputy Director Chairman: Prof. Dr. Jürgen Popp // Scientific Director Prof. Dr. Theo Tschudi Bern, Schweiz Prof. Dr. Benjamin Dietzek // R & D Strategy Frank Sondermann // Administrative Director Members: Daniel Siegesmund // Public Relations & Research Dr. Roland Mattheis // Personal ­Marketing Assistant to the Board of Directors Prof. Dr. Hartmut Bartelt Prof. Dr. Cornelia Denz Westfälische Wilhelms-Universität Münster Prof. Dr. Heike Ebendorff-Heidepriem, University of Adelaide, Australien Administration Scientific Coordination Employee Representation Prof. Dr. Wolfgang Kiefer Universität Würzburg Prof. Dr. Wolfgang Mehr IHP Frankfurt (Oder)

_Organization Prof. Dr. Bernd Rech Helmholtz-Zentrum Berlin & TU Berlin _Organization Dr. Gudrun Andrä // Prof. Dr. Monika Ritsch-Marte Universität Innsbruck, Österreich 46 Employee Representative 47 ------Frank Sondermann // Manuela Meuters // Administrative Director Dr. Ivonne Bieber Councillor for Equality Elected in 2014:

Eugen Ermantraut Alere Technologies GmbH, Jena Prof. Dr. Heinz-Wilhelm Hübers Deutsches Zentrum für Luft- und Raumfahrt, Berlin Research Units Prof. Dr. Christian Spielmann Friedrich Schiller University Jena

Departments Groups Left in 2014:

Dipl.-Ing. Klaus Berka Analytik Jena Spectroscopy / Imaging Fiber Optics Research Group Fiber Sensors Prof. Dr. Carsten Fallnich Westfälische Wilhelms-Universität Münster Prof. Dr. Wolfgang Knoll AIT Austrian Institute of Technology, Wien Prof. Dr. Jürgen Popp Prof. Dr. Hartmut Bartelt Prof. Dr. Markus Schmidt Prof. Dr. Richard Kowarschik Friedrich Schiller University Jena

Quantum Detection Nanoscopy Junior Group Clinical Spectro­scopic Diagnostics

Prof. Dr. Hans-Georg Meyer Prof. Dr. Volker Deckert Dr. Ute Neugebauer

Nanobiophotonics Functional Interfaces Junior Group Fiber-­­ Spectro­scopic Sensors

PD Dr. Wolfgang Fritzsche Prof. Dr. Benjamin Dietzek Dr. Torsten Frosch

Microscopy

Prof. Dr. Rainer Heintzmann Members of the Convention Budget of the

Membership of Institutions Institute 2014 Thuringian Ministry of Education, Science and Culture, Erfurt, represented by Frau Bianca Kizina

Thuringian Ministry of Economy, Labour and Technology, Erfurt, represented by MD Dr. Frank Ehrhardt in T € City of Jena, represented by the Lord Mayor Dr. Albrecht Schröter Institutional Funding (Free State of Thuringia) 10.413,7 Friedrich Schiller University Jena, represented by Dr. Jörg Neumann Project Funding 10.619,5 University of Applied Sciences Jena, represented by the President Prof. Dr. Gabriele Beibst 21.033,2

CiS e. V., Erfurt, represented by Dr. Hans-Joachim Freitag Institutional Funding: use

Leibniz Institute for Solid State and Staff 6.185,2

_Organization Materials Research, Dresden, represented by Prof. Dr. Ludwig Schultz _Organization Materials 3.004,4 48 49 ------Sparkasse Jena, represented by Ehrhard Bückemeier ------Investments 1.224,1 TÜV Thuringia e. V., Erfurt, represented by Volker Höhnisch 10.413,7 4H Jena Engineering GmbH, represented by Michael Boer Categorization of Project Funding Robert Bosch GmbH, Stuttgart, represented by Dr. Achim Moritz Federal ministries 2.306,3 j-fiber GmbH, Jena, represented by Lothar Brehm German Research Foundation 566,1 Personal Members (In addition, IPHT scientists spent DFG funds of 152,6 T € at the University of Jena.) Prof. Dr. Hartmut Bartelt Leibniz Institute of Photonic Technology, Jena Free State of Thuringia 3039,1 Dr. Klaus Fischer Jena-Cospeda (Thereof for restructuring within the framework of EFRE: 338,1 T €) Prof. Dr. Peter Görnert Innovent e. V., Jena European Union 891,6 Elke Harjes-Ecker Thuringian Ministry of Education, Science and Culture, Erfurt Contracts of Public Institutions 102,5 Prof. Dr. Hans Eckhardt Hoenig Erlangen Other Fundings 402,5 Bernd Krekel Commerzbank AG, Jena Subcontracts 629,7 Prof. Dr. Jürgen Popp Leibniz Institute of Photonic Technology, Jena R&D Contracts 2681,7 Frank Sondermann Leibniz Institute of Photonic Technology, Jena 10.619,5 Prof. Dr. Herbert Stafast Jena Staff of the Imprint Institute 2014

Full-time Equivalents People

Institutional Third Party Funding Funding Others Total

Scientists 26,2 52,9 - 79,1 84

Visiting Scientists** - - - - 26

External financed Scientists* - - - - 16

* _Organization External financed Employers - - - - 2

50 ------External financed Doctoral ­Candidates* - - - - 42 Publisher: Leibniz Institute of Photonic Technology e. V. Doctoral Candidates 6,5 26,6 - 33,1 56 Location: Technical Staff 35,1 37,5 - 72,6 77 Albert-Einstein-Str. 9, 07745 Jena, Germany

Administration 14,4 - - 14,4 15 Postal Address: PF 100 239, 07702 Jena, Germany Management 5,7 3 5 13,7 15 Phone | Fax: Trainees 1 - - 1 1 +49 (0) 3641 · 206 00 | +49 (0) 3641 · 206 399

Total Staff 88,9 120,0 5,0 213,9 334 Editorial Staff: Britta Opfer, Daniel Siegesmund, Frances Karlen, Andreas Wolff, Manuela Meuters

Artwork: www.genausonuranders.de

Photographes: Sven Döring _Agentur Focus, Hamburg; Emanuel Mathias _photomultiple, Leipzig; IPHT Jena

Printing: Grafisches Centrum Cuno GmbH und Co KG, Calbe (Saale)

© IPHT Jena, www.genausonuranders.de _02.2015 * Employees who are not paid through the payroll of IPHT, but have their main focus on IPHT. ** Visiting scientists who worked more than a month on IPHT in 2014. No use of the key date regulation December 31. www.ipht-jena.de Leibniz Institute of Photonic Technology e. V.

Location: Albert-Einstein-Str. 9 07745 Jena Germany

Postal Address: PF 100 239 07702 Jena Germany www.ipht-jena.de

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