SugarSugar metabolismmetabolism andand degenerativedegenerative diseasesdiseases

MainMain actoractor :: InsulinInsulin SupportingSupporting actoractor :: ResistanceResistance ProducerProducer :: CarbohydratesCarbohydrates DirectorDirector :: WillpowerWillpower MessengerMessenger :: JakobJakob JaggyJaggy hMDhMD FollowFollow thethe mainmain actorsactors

-- InsulinInsulin imbalanceimbalance (speak(speak InsulinInsulin -- resistance)resistance) isis involvedinvolved inin almostalmost everyevery chronicchronic degenerativedegenerative diseasedisease knownknown toto mankind.mankind.

-- TheseThese includeinclude butbut areare notnot limitedlimited toto :: diabetes,diabetes, CAD,CAD, hypertension,hypertension, osteoporosis,osteoporosis, arthritis,arthritis, hypothyroidism,hypothyroidism, elevatedelevated TGTG andand cholesterol,cholesterol, hormonehormone imbalanceimbalance (estrogen(estrogen dominance),dominance), metabolicmetabolic syndrome,syndrome, cancer...cancer... LastLast butbut notnot leastleast

-- InsulinInsulin mightmight be,be, asas aa singlesingle marker,marker, thethe bestbest oneone toto assessassess longevity.longevity.
-- WhatWhat dodo aa lotlot ofof centenerianscentenerians havehave inin common?common? TheyThey havehave aa lowlow InsulinInsulin andand bloodblood sugarsugar level.level.
-- JeanJean CalumetCalumet ofof FranceFrance waswas thethe oldestoldest recordedrecorded humanhuman toto havehave livedlived (122(122 yearsyears old).old). WhatWhat’’ss agingaging anyway?anyway?

-- ChronologicalChronological vsvs biologicalbiological ageage
-- BiologicalBiological ageage isis determineddetermined byby :: genesgenes ,, raterate ofof aging(Insulinresistanceaging(Insulinresistance),), raterate ofof damagedamage toto thethe tissuetissue (oxidation(oxidation andand glycationglycation).).
-- SugarSugar stickssticks toto proteinprotein andand transformstransforms itit inin thethe processprocess == glycationglycation.. AsAs wewe ageage wewe becomebecome rancidrancid andand caramelizedcaramelized A.G.E.sA.G.E.s ????

-- A.G.E.sA.G.E.s standsstands forfor advancedadvanced glycatedglycated endend products.products.

-- DNADNA repairrepair enzymesenzymes cancan getget glycatedglycated also.also. BackBack toto InsulinInsulin

-- InsulinInsulin waswas thethe firstfirst hormonehormone mademade inin anyany organism.organism.
-- InsulinInsulin primarilyprimarily waswas aa hormonehormone thatthat helpedhelped humanshumans getget throughthrough feastfeast andand faminefamine periods.periods. (No(No wastewaste glucoseglucose hormone).hormone).
P.S.P.S. 44 hormoneshormones toto upregulateupregulate bloodsugarbloodsugar,, 11 toto downregulatedownregulate?? InsulinInsulin andand itsits rolesroles

-- AtAt aa cellularcellular levellevel :: glucoseglucose transport,transport, anabolicanabolic hormonehormone (muscle(muscle builder),builder), magnesiummagnesium transport,transport, calciumcalcium transport,transport, conversionconversion ofof T4T4 toto T3T3 (in(in thethe liver),liver), GHGH efficacyefficacy throughthrough productionproduction IgFIgF’’ss ((somatomedinsomatomedin c),c), nitricnitric oxideoxide productionproduction FurtherFurther functionsfunctions

-- OnOn aa nonnon cellularcellular levellevel :: storestore glucoseglucose (glycogen,(glycogen, saturatedsaturated fat),fat), sodiumsodium retention,retention, stimulantstimulant ofof thethe sympatheticsympathetic NS,NS, bloodblood lipidlipid production,production, mitogenicmitogenic hormone,hormone, bloodblood clotclot formation,formation, cholesterol,cholesterol, sexsex hormonehormone (mostly(mostly estrogen)estrogen) andand SHBGSHBG productionproduction ColorectalColorectal cancercancer

““FoodFood groupsgroups andand riskrisk ofof colorectalcolorectal cancercancer inin ItalyItaly””,, IntInt JJ ofof caca
GlycemicGlycemic overload,overload, fromfrom eithereither refinedrefined sugarsugar oror starchstarch intake,intake, increasesincreases bloodblood insulin,insulin, anan importantimportant growthgrowth factorfactor inin thethe humanhuman coloniccolonic mucosamucosa andand thereforetherefore increasesincreases colorectalcolorectal cancercancer risk.risk. InsulinInsulin resistanceresistance

-- TheThe higherhigher thethe amountamount ofof sugarsugar inin thethe bloodblood asas aa resultresult ofof lowlow fiberfiber carboscarbos andand stress,stress, thethe higherhigher thethe overalloverall amountamount ofof circulatingcirculating insulininsulin andand overover timetime thethe lowerlower thethe sensitivitysensitivity ofof thethe cellscells toto insulin.insulin. TheThe efffectsefffects ofof stressstress

-- increasesincreases CortisolCortisol ,, bloodblood sugarsugar elevationelevation
-- decreasesdecreases DHEADHEA productionproduction
-- lossloss ofof TestosteroneTestosterone
-- blocksblocks TSHTSH productionproduction andand conversionconversion ofof T4T4 toto T3T3
-- EstrogenEstrogen dominancedominance throughthrough lossloss ofof progesteroneprogesterone
-- increaseincrease inin freefree radicalradical productionproduction ProgressionProgression ofof resistanceresistance

-- firstfirst thethe liverliver decreasesdecreases productionproduction ofof sugarsugar duringduring thethe day,day, increasesincreases atat nightnight
-- nextnext thethe musclesmuscles cancan’’tt burnburn sugarsugar
-- thenthen fatfat cellscells quitquit storingstoring sugarsugar asas fatfat
-- finallyfinally thethe endothelialendothelial cellscells dondon’’tt proliferateproliferate anymoreanymore
WHENWHEN ALLALL THETHE CELLSCELLS AREARE RESISTANT,RESISTANT, YOURYOUR WEIGHTWEIGHT REACHESREACHES AA PLATEAU.PLATEAU. WhyWhy dodo wewe eateat ??

-- toto produceproduce energyenergy ((carboscarbos andand fats)fats) goodgood fatsfats cancan bebe thethe primaryprimary energyenergy source.source.

-- toto maintainmaintain andand repairrepair (fats(fats andand proteins)proteins) AreAre carbohydratescarbohydrates useful?useful?

-- ItIt isis thethe fiber,fiber, vitaminvitamin andand mineralmineral contentcontent thatthat determinesdetermines ifif aa carbcarb isis usefuluseful oror not.not.

-- 22 TGTG moleculesmolecules == 11 glucoseglucose moleculemolecule (you(you cancan livelive withoutwithout eatingeating carboscarbos)) HowHow toto reversereverse InsulinInsulin resistanceresistance

-- oneone keywordkeyword isis CRONCRON (caloric(caloric restrictionrestriction withwith optimumoptimum nutrition)nutrition)
-- otherother keywordkeyword NUTRIENTNUTRIENT DENSEDENSE FOODSFOODS
-- littlelittle carboscarbos,, mainlymainly inin thethe formform ofof freshfresh aboveabove groundground vegetablesvegetables
-- learnlearn toto distinguishdistinguish betweenbetween physicalphysical andand emotionalemotional foodfood cravingscravings
-- exercise,exercise, exerciseexercise…….. TheThe TopTop 1515

-- MineralsMinerals :: magnesium,magnesium, chromium,chromium, vanadium,vanadium, seleniumselenium

-- VitaminsVitamins :: ALA,ALA, B1,B1, D,D, A,A, EE

-- HerbsHerbs :: gymnemagymnema,, milkmilk thistle,thistle,

-- OthersOthers :: cinnamon,cinnamon, argininearginine,, fiber,fiber, fish/olivefish/olive oiloil NoNo surprisesurprise here!here!

-- CaffeineCaffeine andand smokingsmoking havehave aa negativenegative effecteffect onon InsulinInsulin sensitivity.sensitivity.
-- CaffeineCaffeine alsoalso isis aa majormajor culpritculprit inin hypoglycemiahypoglycemia SomeSome mineralmineral studiesstudies

““MagnesiumMagnesium deficiencydeficiency isis associatedassociated withwith insulininsulin resistanceresistance inin obeseobese children,children,”” DiabetesDiabetes carecare
““Chromium,Chromium, glucoseglucose tolerancetolerance andand diabetesdiabetes””,, BiologicalBiological tracetrace elementelement researchresearch SomeSome vitaminvitamin studiesstudies

“Effect of thiamine on glucose utilization in hepatic cirrhosis”, J of gastroenterology and hepatology
“Correlation between vitamin D3 deficiency and insulin resistance in pregnancy”, Diabetes metab res review
“Relation between dietary vitamin (A) intake and resistance to insulin-mediated glucose disposal in healthy volunteers”, Am J clin nut
“Pharmacological doses of vitamin E improve insulin action in healthy subjects and in non-insulin- dependant diabetic patients”, Am J clin nut HerbalHerbal studiesstudies

““SilymarinSilymarin reducesreduces hyperinsulinemiahyperinsulinemia andand dailydaily insulininsulin needneed inin cirrhoticcirrhotic diabeticdiabetic patientspatients””,, CurrCurr therther resres
““AsianAsian herbherb forfor diabetesdiabetes toto bebe testedtested inin clinicalclinical trialtrial””,, FamFam practpract newsnews OtherOther studiesstudies

““ IsIs insulininsulin resistanceresistance influencedinfluenced byby dietarydietary linoleiclinoleic acidacid andand transtrans fattyfatty acidsacids””,, FreeFree radicalradical biolbiol && medmed
““AA MUFAMUFA--richrich dietdiet improvesimproves postprandialpostprandial glucoseglucose inin insulininsulin--resistantresistant subjectssubjects””,, JJ AmAm collcoll nutnut
““MechanismsMechanisms ofof thethe effecteffect ofof grainsgrains onon insulininsulin andand glucoseglucose responsesresponses””,, JJ AmAm collcoll nutnut

FinallyFinally

-- CheckCheck fastingfasting InsulinInsulin andand bloodblood sugarsugar levellevel
-- EatEat highhigh fiberfiber carboscarbos
-- ChooseChoose qualityquality proteinsproteins andand fatsfats
-- EatEat asas muchmuch nutrientsnutrients inin asas littlelittle caloriescalories asas possiblepossible
-- DeDe--stressstress
-- ExerciseExercise
-- AvoidAvoid caffeinecaffeine andand tobaccotobacco THANKTHANK YOUYOU