2000 LDRD Annual Report

Total Page:16

File Type:pdf, Size:1020Kb

2000 LDRD Annual Report Abstract This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 2000. In addition to a programmatic and financial overview, the report includes progress reports from 244 individual R&D projects in 13 categories. This work was supported by the United States Department of Energy under Contract DE-AC04-94-AL85000. Cover (Above) Sandia is a multiprogram laboratory operated by Sandia Corporation, a The LDRD Program supports the DOE’s and the Laboratories’ Lockheed Martin Company, for the missions through Sandia’s four primary strategic objectives: United States Department of Energy. nuclear weapons, nonproliferation and materials control, energy and critical infrastructure, and emerging national security threats. SAND 2001-1126 To meet these objectives, LDRD promotes creative and innovative March, 2001 research and development that Labs Director Ambassador C. Paul Robinson describes as “… the lifeblood of the Laboratories.” Over 90% of all Sandia National Laboratories’ LDRD projects provide both direct and indirect benefit to the national security and weapons missions of the Laboratories and the DOE. LDRD Annual Report Staff: W t The Science and Technology (S&T) Research Foundations Chuck Meyers category prioritizes investigations to ensure overall relevance to Cynthia Harvey the Labs’ nuclear weapons mission while building upon anticipated Donna Chavez future directions of the Laboratories. LDRD is a key component Bryon Cloer of the weapons research effort that enables Sandia’s continuing ability to meet its commitments in surety, microsystems, manufacturing, radiation physics, and neutron generators research and development. TECHnically Carol Whiddon WRITE Joy Bemesderfer Donna Drayer In addition, LDRD’s research investigations also promote t W Douglas Prout innovation aligned with the nonweapons missions of the Laboratories. These Roadmap Technologies research category investments derive their scientific and technology basis from the S&T competencies, are strategically important for future Sandia national security missions needs, and represent a spectrum of research leading to development and application. Sandia National Laboratories LDRD Annual Report 2000 3 Table of Contents 12 “...exceptional service in the national interest.” 63 Nonvolatile Protonic Memory 13 Laboratory Directed Research and 66 Next-Generation Output-Based Process Control: Development (LDRD) Program Overview An Integration of Modeling, Sensors, and Intelligent Data Analysis Materials Science & Technology 68 Functional Materials for Electrochemo- mechanical Actuation of Microvalves and Micropumps 32 Functional Materials for Microsystems: Smart Self-Assembled Photochromic Films 70 Making the Connection Between Microstructure and Mechanics 34 Innovative Experimental and Computational Diagnostics for Monitoring Corrosion in 72 Switchable Hydrophobic-Hydrophilic Surfaces Weapons Environments 74 Nanostructured Materials Integrated in 37 Self-Healing Molecular Assemblies for Control Microfabricated Optical Devices of Friction and Adhesion in MEMS 76 All-Ceramic Thin-Film Battery 39 Linking Atomistic Computations with Phase- Field Modeling 41 A Combinatorial Microlab Investigation of Computer Science Critical Copper-Corrosion Mechanisms 79 Heterogeneous Simulation 43 Self-Assembled Templates for Fabricating Novel Nanoarrays and Controlling Materials 81 Volumetric Video Motion Sensing for Growth Unobtrusive Human-Computer Interactions 45 Wetting and Spreading Dynamics of Solder and 83 Hybrid Sparse-Dense Incomplete Factorization Braze Alloys Preconditioners 48 Improved Materials-Aging Diagnostics and 85 Advanced Large-Eddy Simulation Algorithms Mechanisms Through 2-D Hyperspectral for Coupled-Flow Physics and Complex Imaging Methods and Algorithms Geometry 52 Microscale Shock-Wave Physics Using 87 Molecular Simulation of Reacting Systems Photonic Driver Techniques 89 Massively Parallel Global Climate Model for 54 Reactivity of Metal-Oxide Surfaces Paleoclimate Applications 57 Exploiting LENS Technology Through 91 From Atom-Picoseconds to Centimeter-Years in Novel Materials Simulation and Experiment 60 Molecular Characterization of Energetic- 93 Parallel Combinatorial Optimization for Material Initiation Scheduling Problems Sandia National Laboratories LDRD Annual Report 2000 4 Table of Contents 96 Multilevel Techniques for Unstructured Grid 129 Quantum Tunneling Transistors for Practical Problems on Massively Parallel Computers Applications 99 Visual Explanation and Insight 131 Development of Magnetically Excited Flexural Plate-Wave Devices for Implementation as 102 Emergent Behavior of Large Swarms of Physical, Chemical, and Acoustic Sensors, and Intelligent Agents as Integrated Micropumps for Sensored Systems 104 Algorithmic Advances in Computational Structural Biology 134 Novel Acoustically Driven Microoptoelectronic Devices 106 Predicting Function of Biological Macromolecules 136 Photonics Integration Devices and Technologies 108 Large-Scale Nonlinear Optimization Arising from PDE Models 139 Stress-Free Amorphous Diamond for High- Sensitivity Microsensors with Integrated 110 Parallel Methods for Coupling Circuit- and Microstructures Device-Scale Simulations 142 AlGaN Materials Engineering for Integrated 112 A Java-Based Tool for Multifidelity Modeling Multifunction Systems of Coupled Systems 144 Semiconductor Current Filament Lasers 114 Gamma-Ray Bursts and the Particle Mass Scale 147 SOI–Based High-Aspect-Ratio Si Bulk Micromachining for MEMS Applications Electronics & Photonics 150 Defining the Frontiers of Vertical, External- 117 Monolithic Integration of VCSELs and Cavity, Surface-Emitting Lasers Detectors for Microsystems 153 Photoresist Technology for 70 nm Lithography 119 Post-Processed Integrated Microsystems with 157 nm Radiation 122 Development of Radiation-Hard Sensors for 155 Growth and Characterization of Quantum Dots Space-Based Visible and Infrared Sensing and Quantum Dot Devices Applications 158 THz Technologies for Ultrahigh-Data-Rate 124 Silicon Three-Dimensional Photonic Crystal and Communications Its Applications 160 New Architectures for Micro-Total-Analytical 126 Monolithic Micromachined Variable Tuners for Systems Rapid Prototyping and Optimization of Microwave Circuits 162 Heterogeneous Integration of Optoelectronic Arrays and Microelectronics Sandia National Laboratories LDRD Annual Report 2000 5 Table of Contents 164 Biosensors Based on the Electrical Impedance 198 Innovative Measurement Diagnostics for Fluid/ of Tethered Lipid Bilayers on Planar Electrodes Solid and Fluid/Fluid Interactions in Rotating Flowfields 166 Miniature Sensors for BW Agents Using Fatty- Acid Profiles 201 High-Resolution Modeling of Multiscale Transient Phenomena in Turbulent Boundary 168 Enhanced-Sensitivity Acoustic-Wave Biosensor Layers Arrays 203 Dispersive Measurements of Velocity in 171 High-Al-Content AlGaInN Devices for Next- Heterogeneous Materials Generation Electronic and Optoelectronic Applications 206 A Physically Based Computational Method for Predicting Generalized Fracture 173 Microfabrication of Electromagnetic Devices 209 Micromechanical Failure Analyses for Finite- 175 GaAs MOEMS Technology Element Polymer Modeling 178 Integrated Microsensors for Autonomous Microrobots Advanced Manufacturing 180 Silicon-Integrated Planar Microbatteries 212 Microdiagnostic MEMS Lab-on-a-Chip 182 High-Efficiency Optical MEMS by the 214 Real-Time Error Correction Using Integration of Photonic Lattices with Surface Electromagnetic-Bearing Spindles MEMS 216 Thin-Film Deposition Processes Incorporating In Situ Monitoring Capabilities Engineering Modeling & Simulation 218 Solid-State Neutron Generator for Use in 185 Development of In Situ Diagnostics for Nuclear Weapons Simultaneous Measurement of Transient Gas Species and Soot in Large Fires 220 Scripting for Video Inspection 188 Structural Simulations Using Multiresolution 223 Advanced Machining Processes for Material Models Microfabrication 190 Mechanisms of Adiabatic Shear Failure 225 Advanced Production Planning Models 192 Evolvable Hardware 228 Volumetric Displacement Control (VDC) of Manufacturing Tools 194 Crack Nucleation and Growth: Combining Validated Atomistic and Continuum Modeling 230 Process-Based Quality Tools to Verify Cleaning and Surface Preparation 196 Applied Microfluidic Physics Sandia National Laboratories LDRD Annual Report 2000 6 Table of Contents 232 Fabrication of Three-Dimensional 264 Optical Backplane/Interconnect for Super-High- Microstructures Using Soft Lithography Speed Communication 234 Automatic Design of Practical Fixtures 266 PUSH Technology Demonstration 236 IMEMS Packaging and Interconnection 268 Controlling Information: Its Flow, Fusion, and Technology Coordination 238 Microreplication: Precision Metal Parts from 271 Low-Power, Reduced-Computation, Public-Key Electroformed Master Molds Protocols 240 Assembly of LIGA Using Electric Fields 273 Ten-to-One-Hundred-Gigabit/Second Network- Enabling R&D 241 Computer Numerically Controlled Micromachines 276 Intrusion Detection for Asynchronous Transfer Mode (ATM) Networks 244 Electromicrofluidic Packaging 278 Conversational Policies for Multiagent Systems Information Systems & Technology 280 Fuzzy Data Mining 247 Weighted-Nearest-Neighbor (WNN) Decision Making for Data Mining Directed Energy 249 Varying QoS for Fixed and Mobile Networks 283 Surface Decontamination of Bacterial Protein Toxins by RF Power 251 A Real-Time Decision-Support Framework to Guide Facility
Recommended publications
  • C:\Documents and Settings\Owner
    A Multi-Media Guide to Shopping, Dining, Lodging, Recreation, Entertainment, Art & Historic Points of Interest for The American Heritage Tourist EVENTS... 4 INDEX OF CITIES... 6-7 ON THE ROAD... 27 Establish Your Community as a GREAT AMERICAN DESTINATION FALL / WINTER 2017-2018 (for less than a dime a day per lister) www.AmericanAntiquities.com See inside front cover 2 / AMERICAN JOURNAL Volume 25, FALL/WINTER 2017-18 AMERICAN ANTIQUITIES JOURNAL Volume 25, FALL/WINTER 2017-18/ 3 Enjoy your next road trip to one of our 500+ client cities. Let this be your guide for AboutAbout thethe CoCovverer shopping, dining, lodging, recreation, entertainment & historic points of interest for the AMERICAN HERITAGE TOURIST www.AmericanAntiquities.com Depression glass is clear or a specified number of colored translucent magazine subscriptions, thus glassware. It was produced in making its way into almost a multitude of colors, ranging every American home. from the deep colors of purple, Depression glass started one black, cobalt, and red to the of the largest collecting trends pastels of pink, yellow, green, ever, from collectors to amber, and blue which nostalgia hunters. Over created to bring a bright note 100,000 eager collectors now into the otherwise drab times seek this prized glass, of the depression. Most of this whether to complete a glassware was made in the handed-down family set of Ohio River Valley of the United dishes, or to find the highly States, where access to raw sought and elusive rare materials and power made pieces. manufacturing inexpensive. Depression glass is More than twenty becoming more scarce on the manufacturers made more open market.
    [Show full text]
  • Chapter 7 Immersive Journalism: the New Narrative Doron Friedman and Candice Kotzen
    “9.61x6.69” b3187 Robot Journalism: Can Human Journalism Survive? FA Chapter 7 Immersive journalism: The new narrative Doron Friedman and Candice Kotzen Immersive journalism is a subcategory of journalism that uses virtual reality (VR) and similar technologies to provide those engaging in such technologies with a sense of being wholly engrossed in the news story, thus allowing the news audience to form a direct impression of the ambience of the story. This chapter is intended to serve as a primer of VR use for news storytelling for individuals with an interest or background in journalism. The first section presents some essential background on VR and related technologies. Next, we present some research findings on the impact of VR, and review some of the early work in immersive journalism. We conclude by delineating a collection of thoughts and questions for journalists wishing to enter into this new exciting field. 1. The Technology More than 50 years after the first demonstration of virtual reality (VR) technologies [Sutherland, 1965], it is apparent that VR is on the brink of becoming a form of mass media as VR documentary and journalism has been a central theme. Triggered by Facebook’s acquisition of Oculus Rift in 2014, the technology industry launched the race to deliver compelling VR hardware, software, and content. In this chapter, we present the essential background for non-experts who are intrigued by immer- sive journalism. For a recent comprehensive review of VR research in general, we recommend Slater and Sanchez-Vives [2016]. Relevant issues from this review are elaborated below.
    [Show full text]
  • To DNA Microarrays
    Glass slides to DNA microarrays by Samuel D. Conzone* and Carlo G. Pantano† A tremendous interest in deoxyribonucleic acid Most individuals, outside of academic circles focused (DNA) characterization tools was spurred by the on genomics, became aware of the potential mapping and sequencing of the human genome. commercial, technical, and social importance of the New tools were needed, beginning in the early 1990s, human genome project during the late 1990s. The human genome project was formally initiated in to cope with the unprecedented amount of genomic 19901 and was expected to last 15 years. It had the information that was being discovered. Such needs major goals of identifying all the genes in human led to the development of DNA microarrays; tiny DNA, determining the sequences of those genes, and gene-based sensors traditionally prepared on coated storing the information in public databases. glass microscope slides. The following review is However, the project moved quickly from the onset intended to provide historical insight into the advent and, by 1998, the Department of Energy (DOE) and of the DNA microarray, followed by a description of the National Institutes of Health (NIH) predicted the technology from both the application and that the human genome project would be completed by 2003. fabrication points of view. Finally, the unmet challenges and needs associated with DNA The big buzz about biotech microarrays will be described to define areas of The tremendous success in rapidly mapping and sequencing potential future developments for the materials the human genome (a working draft sequence of the human researcher. genome was completed in 2000), has led many commentators to predict that similar achievements would follow on the applications side, giving rise to unprecedented discoveries related to human health2,3.
    [Show full text]
  • Advanced Volumetric Capture and Processing
    ADVANCED VOLUMETRIC CAPTURE AND PROCESSING O. Schreer, I. Feldmann, T. Ebner, S. Renault, C. Weissig, D. Tatzelt, P. Kauff Fraunhofer Heinrich Hertz Institute, Berlin, Germany ABSTRACT Volumetric video is regarded worldwide as the next important development step in media production. Especially in the context of rapidly evolving Virtual and Augmented Reality markets, volumetric video is becoming a key technology. Fraunhofer HHI has developed a novel technology for volumetric video: 3D Human Body Reconstruction (3DHBR). The 3D Human Body Reconstruction technology captures real persons with our novel volumetric capture system and creates naturally moving dynamic 3D models, which can then be observed from arbitrary viewpoints in a virtual or augmented reality scene. The capture system consists of an integrated multi-camera and lighting system for full 360 degree acquisition. A cylindrical studio has been developed with a diameter of 6m and it consists of 32 20MPixel cameras and 120 LED panels that allow for arbitrary lit background. Hence, diffuse lighting and automatic keying is supported. The avoidance of green screen and provision of diffuse lighting offers best possible conditions for re-lighting of the dynamic 3D models afterwards at design stage of the VR experience. In contrast to classical character animation, facial expressions and moving clothes are reconstructed at high geometrical detail and texture quality. The complete workflow is fully automatic, requires about 12 hours per minute of mesh sequence and provides a high level of quality for immediate integration in virtual scenes. Meanwhile a second, professional studio has been built up on the film campus of Potsdam Babelsberg. This studio is operated by VoluCap GmbH, a joint venture between Studio Babelsberg, ARRI, UFA, Interlake and Fraunhofer HHI.
    [Show full text]
  • Architecture of Thermal Adaptation in an Exiguobacterium Sibiricum Strain
    BMC Genomics BioMed Central Research article Open Access Architecture of thermal adaptation in an Exiguobacterium sibiricum strain isolated from 3 million year old permafrost: A genome and transcriptome approach Debora F Rodrigues*1, Natalia Ivanova2, Zhili He3, Marianne Huebner4, Jizhong Zhou3 and James M Tiedje1 Address: 1Michigan State University, NASA Astrobiology Institute and Center for Microbial Ecology, East Lansing, MI 48824, USA, 2DOE Joint Genome Institute, Walnut Creek, CA 94598-1604, USA, 3Institute for Environmental Genomics, Department of Botany and Microbiology, University of Oklahoma, Norman, OK, USA and 4Michigan State University, Department of Statistics and Probability, East Lansing, MI, USA Email: Debora F Rodrigues* - [email protected]; Natalia Ivanova - [email protected]; Zhili He - [email protected]; Marianne Huebner - [email protected]; Jizhong Zhou - [email protected]; James M Tiedje - [email protected] * Corresponding author Published: 18 November 2008 Received: 23 May 2008 Accepted: 18 November 2008 BMC Genomics 2008, 9:547 doi:10.1186/1471-2164-9-547 This article is available from: http://www.biomedcentral.com/1471-2164/9/547 © 2008 Rodrigues et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Many microorganisms have a wide temperature growth range and versatility to tolerate large thermal fluctuations in diverse environments, however not many have been fully explored over their entire growth temperature range through a holistic view of its physiology, genome, and transcriptome.
    [Show full text]
  • The Depression Era Pdf, Epub, Ebook
    CENTRAL GLASS WORKS: THE DEPRESSION ERA PDF, EPUB, EBOOK Tim Schmidt | 192 pages | 01 Jun 2004 | Schiffer Publishing Ltd | 9780764320163 | English | Atglen, United States Central Glass Works: The Depression Era PDF Book Comic Books. To find a value for your vintage glassware, shop around. Nonetheless, stock prices continued to rise, and by the fall of that year had reached stratospheric levels that could not be justified by expected future earnings. Answer: When we think of Depression Glass, we usually think of the popular dishware manufactured during that period. Lorraine — Also known as pattern No. Model Trains. The early history of the companies and operations which became the Indiana Glass Company are confusing, convoluted and not terribly well documented! And those relief programs for which blacks were eligible on paper were rife with discrimination in practice, since all relief programs were administered locally. Feel the heft of it. Princess is often found in pink and green, followed by yellow and occasionally in light blue. Jobs available to women paid less, but were more stable during the banking crisis: nursing, teaching and domestic work. Many cookie jars were made in colors not originally associated with Mayfair, but the pink and light blue versions can be troublesome for new collectors. It went over to mass production in the s. Consignment shops also must collect a percentage of the sold price. Pyramid — also known as pattern No. For instance, English Hobnail and Miss America can look very similar with just a cursory inspection. Most often found in pink and monax. Lincoln's Depression. Cookie jars and shot glasses have been reproduced in the Mayfair pattern.
    [Show full text]
  • Copyrighted Material
    PART I METHODS COPYRIGHTED MATERIAL CHAPTER 1 Overview of Thermochemistry and Its Application to Reaction Kinetics ELKE GOOS Institute of Combustion Technology, German Aerospace Center (DLR), Stuttgart, Germany ALEXANDER BURCAT Faculty of Aerospace Engineering, Technion - Israel Institute of Technology, Haifa, Israel 1.1 HISTORY OF THERMOCHEMISTRY Thermochemistry deals with energy and enthalpy changes accompanying chemical reactions and phase transformations and gives a first estimate of whether a given reaction can occur. To our knowledge, the field of thermochemistry started with the experiments done by Malhard and Le Chatelier [1] with gunpowder and explosives. The first of their two papers of 1883 starts with the sentence: “All combustion is accompanied by the release of heat that increases the temperature of the burned bodies.” In 1897, Berthelot [2], who also experimented with explosives, published his two-volume monograph Thermochimie in which he summed up 40 years of calori- metric studies. The first textbook, to our knowledge, that clearly explained the principles of thermochemical properties was authored by Lewis and Randall [3] in 1923. Thermochemical data, actually heats of formation, were gathered, evaluated, and published for the first time in the seven-volume book International Critical Tables of Numerical Data, Physics, Chemistry and Technology [4] during 1926–1930 (and the additional index in 1933). In 1932, the American Chemical Society (ACS) monograph No. 60 The Free Energy of Some Organic Compounds [5] appeared. Rate Constant Calculation for Thermal Reactions: Methods and Applications, Edited by Herbert DaCosta and Maohong Fan. Ó 2012 John Wiley & Sons, Inc. Published 2012 by John Wiley & Sons, Inc. 3 4 OVERVIEW OF THERMOCHEMISTRY AND ITS APPLICATION TO REACTION KINETICS In 1936 was published The Thermochemistry of the Chemical Substances [6] where the authors Bichowsky and Rossini attempted to standardize the available data and published them at a common temperature of 18C (291K) and pressure of 1 atm.
    [Show full text]
  • Appendix a a List of the Program and Data Files on the Disk*
    Appendix A A List of the Program and Data Files on the Disk* 2dnrnr Simulates a IH COSY two-dimensional NMR plot (5.5). Abc Calculates principal moments of inertia for linear and non­ linear molecules (4.5). Acetate Calculates the pH in an acetate buffer (3.2). Anderko Solves the Anderko-Pitzer nonideal gas law (1.2). Aorbital Calculates and plots H atomic orbitals in two dimensions (4.3). Atpl Calculates and plots the apparent standard Gibbs energy I:irGo 1 for the ATP hydrolysis reaction at various pMg's and a specified pH and ionic strength (3.3). Atp2 Calculates and plots the apparent standard Gibbs energy I:irGo 1 for the ATP hydrolysis reaction at various pH's and a specified pMg and ionic strength (3.3). Beattie Solves the Beattie-Bridgeman nonideal gas law (1.2). Beyer Calculates and plots the density of states N(E) and the sum of states G(E) for a molecule's vibrational modes using the Beyer-Swinehart direct-count algorithm (11.4). Biochern Calculates and plots the apparent standard Gibbs energy I:irGo 1 for the F -+ M biochemical reaction at various pH's (3.3). Biokin Calculates and plots extracellular glucose and insulin con­ centrations as functions of time (10.4). Branch Calculates and plots H, 0, OH and 02 concentrations for the branching catalytic cycle that drives the 2H2 + 02 -+ 2H20 reaction (10.2). Brussels Calculates and plots concentrations of intermediates in the autocatalytic Brusselator model (11.5). Butler Calculates and plots the Butler-Volmer and Tafel equations relating electrode current and overpotential (11.6).
    [Show full text]
  • Opto-Fluidic Manipulation of Microparticles and Related Applications
    University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School 11-10-2020 Opto-Fluidic Manipulation of Microparticles and Related Applications Hao Wang University of South Florida Follow this and additional works at: https://scholarcommons.usf.edu/etd Part of the Biomedical Engineering and Bioengineering Commons Scholar Commons Citation Wang, Hao, "Opto-Fluidic Manipulation of Microparticles and Related Applications" (2020). Graduate Theses and Dissertations. https://scholarcommons.usf.edu/etd/8601 This Dissertation is brought to you for free and open access by the Graduate School at Scholar Commons. It has been accepted for inclusion in Graduate Theses and Dissertations by an authorized administrator of Scholar Commons. For more information, please contact [email protected]. Opto-Fluidic Manipulation of Microparticles and Related Applications by Hao Wang A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Engineering Department of Medical Engineering College of Engineering University of South Florida Major Professor: Anna Pyayt, Ph.D. Robert Frisina, Ph.D. Steven Saddow, Ph.D. Sandy Westerheide, Ph.D. Piyush Koria, Ph.D. Date of Approval: October 30, 2020 Key words: Thermal-plasmonic, Convection, Microfluid, Aggregation, Isolation Copyright © 2020, Hao Wang Dedication This dissertation is dedicated to the people who have supported me throughout my education. Great appreciation to my academic adviser Dr. Anna Pyayt who kept me on track. Special thanks to my wife Qun, who supports me for years since the beginning of our marriage. Thanks for making me see this adventure though to the end. Acknowledgments On the very outset of this dissertation, I would like to express my deepest appreciation towards all the people who have helped me in this endeavor.
    [Show full text]
  • WHOI-R-06-006 Ahn, S. Fiber-Optic Microarra
    ..... APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Sept. 2006, p. 5742-5749 Vol. 72, No.9 0099-2240/06/$08.00+0 doi:10.1128/AEM.00332-06 Copyright © 2006, American Society for Microbiology. All Rights ReseiVed. ' Fiber-Optic Microarray for Simultaneous Detection of Multiple Harmful Algal Bloom Species Soohyoun Ahn,lt David M. Kulis,2 Deana L. Erdner,2 Donald M. Anderson,2 and David R. Wale* Department of Chemistry, Tufts University, 62 Talbot Ave., Medford, Massachusetts 02155, 1 and Biology Department, WoodY Hole Oceanographic Institution, Woods Hole, Massachusetts 025432 Received 9 February 2006/Accepted 12 June 2006 Harmful algal blooms (HABs) are a serious threat to coastal resources, causing a variety of impacts on public health, regional economies, and ecosystems. Plankton analysis is a valuable component of many HAB monitoring and research programs, but the diversity of plankton poses a problem in discriminating toxic from nontoxic species using conventional detection methods. Here we describe a sensitive and specific sandwich hybridization assay that combines fiber-optic microarrays with oligonucleotide probes to detect and enumerate the HAB species Alex/lndrium fundyense, AleXIlndrium ostenfeldii, and Pseudo-nitzschia australis. Microarrays were prepared by loading oligonucleotide probe-coupled microspheres (diameter, 3 J.tm) onto the distal ends of chemically etched imaging fiber bundles. Hybridization of target rRNA from HAB cells to immobilized probes on the microspheres was visualized using Cy3-labeled secondary probes in a sandwich-type assay format. We applied these microarrays to the detection and enumeration ofHAB cells in both cultured and field samples. Our study demonstrated a detection limit of approximately 5 cells for all three target organisms within 45 min, without a separate amplification step, in both sample types.
    [Show full text]
  • Clefs CEA N°60
    No. 60 clefsSummer 2011 Chemistry is everywhere No. 60 - Summer 2011 clefs Chemistry is everywhere www.cea.fr No. 60 Summer 2011 clefs Chemistry is everywhere Chemistry 2 Foreword, by Valérie Cabuil is everywhere I. NUCLEAR CHEMISTRY Clefs CEA No. 60 – SUMMER 2011 4 Introduction, by Stéphane Sarrade Main cover picture Dyed polymers for photovoltaic cells. 6 Advances in the separation For many years, CEA has been applying chemistry of actinides, all aspects of chemistry, in all its forms. Chemistry is at the very heart of all its by Pascal Baron major programs, whether low-carbon 10 The chemical specificities energies (nuclear energy and new energy technologies), biomedical and of actinides, environmental technologies or the by Philippe Moisy information technologies. 11 Uranium chemistry: significant P. Avavian/CEA – C. Dupont/CEA advances, Inset by Marinella Mazzanti top: Placing corrosion samples in a high-temperature furnace. 12 Chemistry and chemical P. Stroppa/CEA engineering, the COEX process, by Stéphane Grandjean bottom: Gas sensors incorporating “packaged” NEMS. P. Avavian/CEA 13 Supercritical fluids in chemical Pictogram on inside pages processes, © Fotolia by Audrey Hertz and Frédéric Charton Review published by CEA Communication Division 14 The chemistry of corrosion, Bâtiment Siège by Damien Féron, Christophe Gallé 91191 Gif-sur-Yvette Cedex (France) and Stéphane Gin Phone: + 33 (0)1 64 50 10 00 Fax (editor’s office): + 33 (0)1 64 50 17 22 14 17 Focus A Advances in modeling Executive publisher Xavier Clément in chemistry, by Philippe Guilbaud, Editor in chief Jean-Pierre Dognon, Didier Mathieu, 21 Understanding the chemical Marie-José Loverini (until 30/06/2011) Christophe Morell, André Grand mechanisms of radiolysis and Pascale Maldivi by Gérard Baldacchino Deputy editor Martine Trocellier [email protected] Scientific committee Bernard Bonin, Gilles Damamme, Céline Gaiffier, Étienne Klein, II.
    [Show full text]
  • Chemical File Format Conversion Tools : a N Overview
    International Journal of Engineering Research & Technology (IJERT) ISSN: 2278-0181 Vol. 3 Issue 2, February - 2014 Chemical File Format Conversion Tools : A n Overview Kavitha C. R Dr. T Mahalekshmi Research Scholar, Bharathiyar University Principal Dept of Computer Applications Sree Narayana Institute of Technology SNGIST Kollam, India Cochin, India Abstract— There are a lot of chemical data stored in large different chemical file formats. Three types of file format databases, repositories and other resources. These data are used conversion tools are discussed in section III. And the by different researchers in different applications in various areas conclusion is given in section IV followed by the references. of chemistry. Since these data are stored in several standard chemical file formats, there is a need for the inter-conversion of II. CHEMICAL FILE FORMATS chemical structures between different formats because all the formats are not supported by various software and tools used by A chemical is a collection of atoms bonded together the researchers. Therefore it becomes essential to convert one file in space. The structure of a chemical makes it unique and format to another. This paper reviews some of the chemical file gives it its physical and biological characteristics. This formats and also presents a few inter-conversion tools such as structure is represented in a variety of chemical file formats. Open Babel [1], Mol converter [2] and CncTranslate [3]. These formats are used to represent chemical structure records and its associated data fields. Some of the file Keywords— File format Conversion, Open Babel, mol formats are CML (Chemical Markup Language), SDF converter, CncTranslate, inter- conversion tools.
    [Show full text]