And Schizophrenia: Cross-Sectional Analyses Using the Evidence from 1.9 Million Chinese Adults

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And Schizophrenia: Cross-Sectional Analyses Using the Evidence from 1.9 Million Chinese Adults Open access Research BMJ Open: first published as 10.1136/bmjopen-2018-026532 on 4 September 2019. Downloaded from Individual-level and area-level socioeconomic status (SES) and schizophrenia: cross-sectional analyses using the evidence from 1.9 million Chinese adults Yanan Luo,1 Lei Zhang,1 Ping He,2 Lihua Pang,1 Chao Guo,1 Xiaoying Zheng1 To cite: Luo Y, Zhang L, He P, ABSTRACT Strengths and limitations of this study et al. Individual-level and Objectives Health disparities in schizophrenia are area-level socioeconomic well established. However, it is less understood ► This study is the first study to report the empirical status (SES) and schizophrenia: whether area-level socioeconomic status (SES) is cross-sectional analyses using results of the interaction of individual-level and differentially associated with schizophrenia depending on the evidence from 1.9 million area-level socioeconomic status (SES) and their individual-level SES. Therefore, using a nationally large Chinese adults. BMJ Open association with schizophrenia from a multilevel representative data, this study investigated the association 2019;9:e026532. doi:10.1136/ perspective in mainland China. bmjopen-2018-026532 between individual-level SES, area-level SES and their ► We used a very large-size and population-based interaction with schizophrenia in Chinese adults from a design survey to study the relationship between in- ► Prepublication history and multilevel perspective. additional material for this dividual-level and area-level SES and schizophrenia. Setting Household interviews in 734 counties (districts), paper are available online. To ► The use of International Statistical Classification 2980 towns (streets) and 5964 communities (villages) view these files, please visit of Diseases, 10th Revision Symptom Checklist for from 31 provinces, People's Republic of China, as part the journal online (http:// dx. doi. Mental Disorders as diagnostic tools, as well as the of the cross-sectional survey of Second China National org/ 10. 1136/ bmjopen- 2018- use of experienced clinical psychiatrists as inter- Sample Survey on Disability. 026532). viewers, improved the comparability of the diagnos- Participants 1 909 205 men and women aged 18 years tic process. Received 08 September 2018 old and above. Revised 12 March 2019 ► The population migration between the counties may Primary and secondary outcome measures A screen http://bmjopen.bmj.com/ affect our study results, although the impact of pop- Accepted 07 June 2019 followed by clinical diagnosis was used to identify ulation migration on results is small because of the schizophrenia, and schizophrenia was ascertained restriction from China’s strict migration regulating. according to the International Statistical Classification of ► Further studies need to understand the mechanisms Diseases, 10th Revision (code F20). of SES and schizophrenia, because the cross-sec- Results 1-SD increase in individual SES was associated tional design in this study cannot draw causal with decreased risk of schizophrenia (OR=0.45, 95% inferences. CI 0.43 to 0.46). 1-SD increase in area-level SES was associated with increased risk of schizophrenia (OR=1.30, 95% CI 1.24 to 1.37). The interaction of individual SES on September 30, 2021 by guest. Protected copyright. and area-level SES was statistically significant OR( =1.05, 2–2.5 times mortality rate higher than the 3 95% CI 1.02 to 1.08); as the level of area SES increased, general population, and accompanied by schizophrenia risk of lower SES people grew faster than decreased physical functioning, social partic- the risk of higher SES people. ipation and self-care ability.4 Accumulating © Author(s) (or their Conclusions Area-level SES is particularly important employer(s)) 2019. Re-use evidence reported the social disparities in permitted under CC BY-NC. No to mental health of low SES individuals, with low SES schizophrenia, which increased the mental commercial re-use. See rights people in high SES counties having the highest risk of health inequalities and high burden for and permissions. Published by schizophrenia than other groups. Action to reduce SES healthcare system.5 BMJ. disparities in schizophrenia will require attention to the In considering how to reduce schizophrenia 1Institute of Population area-level context of low SES adults. Research, Peking University, social disparities and perfecting the level Beijing, China of healthcare system, the context in which 2China Center for Health INTRODUCTION risk factors are produced needs to be better Development Studies, Peking Schizophrenia is global public health understood. Robust evidence demonstrates University, Beijing, China concern, causing a total loss of 16.8 million an association between area-level socioeco- 6 Correspondence to disability adjusted life years (DALY) world- nomic status (SES) and schizophrenia. Indi- 1 Xiaoying Zheng; wide and being the leading cause of mental viduals who live in more advantaged areas xzheng@ pku. edu. cn disability.2 People with schizophrenia have are often accompanied by fewer health risk Luo Y, et al. BMJ Open 2019;9:e026532. doi:10.1136/bmjopen-2018-026532 1 Open access BMJ Open: first published as 10.1136/bmjopen-2018-026532 on 4 September 2019. Downloaded from factors and lower mortality rates for schizophrenia.6 7 People’s Republic of China (1996 Amendment). Data Many mechanisms, such as the cost of available resources, are available from the Data Access committee of China environmental exposures (eg, social stress and household Disabled Persons Federation (http://www. cdpf. org. cn/ crowding), elevated inflammation, infections, greater special/ dlzt/ cydc/ index. htm) for researchers who meet allostatic load and vitamin D deficiency, may contribute the criteria for access to confidential data. to schizophrenia as a function of area-level SES.7–10 It is clear that, independent of individual-level SES, area- Patient and public involvement level SES is associated with the risk of schizophrenia.11 It is a population-based survey conducted to ascertain However, it is unclear whether this linkage of area SES the prevalence, socioeconomic conditions and demand will be stronger or weaker depending on individual SES. of rehabilitation services of the handicapped persons in Four relevant theoretical models were used to interpret China. The results of this survey will help stakeholders that how area SES and individual SES may interact in rela- to understand the survival status of the disabled and find tion to health: the double jeopardy hypothesis, collective the useful medical and rehabilitation services for them. A resources model, fundamental cause theory and the rela- total of 1 909 205 individuals aged 18 years or older from tive deprivation hypothesis.12 13 The first three models all 31 provinces, autonomous regions and municipalities in predict the similar pattern, which indicate that the health China participated in this survey. Of these, 7628 patients of lower SES individuals will be particularly worse off if with schizophrenia were involved. Study subjects only they reside in lower SES areas. Whereas the relative depri- participated the collection of study data. All patients can vation hypothesis regards that the health of lower SES be informed of the health examinations results in free of individuals may be worse if they live in higher SES areas charge in this survey. than if they reside in lower SES areas. To our best knowledge, little evidence was focusing Schizophrenia assessment area-level SES and the cross-level interaction between This survey identified schizophrenia by the combination area-level and individual-level SES with schizophrenia of self-reports or family members’ reports and on-site in Chinese mainland. Moreover, no evidence used the diagnosis by psychiatrists: counties as the units to study this issue. As the particu- First, this survey used a questionnaire to screen partici- larly important administrative unit in China, county, with pants who were likely to be meeting thresholds to indicate average 500 000persons, is the lowest most basic layer at psychiatric morbidity/difficulties. People meeting thresh- which the public health policy functioned.14 Studying olds to indicate psychiatric morbidity/difficulties was the schizophrenia issue at the county level would be defined as persons who were affected by psychiatric disor- very helpful for perfecting the level of mental health- ders for more than 1 year and experienced disturbance in care system and promoting psychiatric policies in China. cognition, emotion and behaviour that had impacted on Accordingly, this study would use a nationally large repre- their daily living activities and social participation. This http://bmjopen.bmj.com/ sentative data to investigate county-level and individu- survey used a screening questionnaire to identify partic- al-level SES and their interaction with schizophrenia in ipants who were meeting thresholds to indicate psychi- Chinese mainland. atric morbidity/difficulties by face-to-face interview. This questionnaire was developed according to the ‘Guide- lines and Principles for the Development of Disability METHODS Statistics’, recommended by the United Nations.16 It had Study population been tested in three pilot studies and had been demon- 17 Participants in this analysis were members of Second strated high reliability in Chinese population. The on September 30, 2021 by guest. Protected copyright. National Sample Survey on Disability. This survey is a questionnaire
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