Recent FMD situation and control strategies in

Dr.Shiqi Sun [email protected]

The national FMD reference laboratory of the People’s Republic of China Veterinary Research Institute, CAAS

2011-12-01 Contents 1Th1.The recen t ou tbrea ks o fFMDif FMD in China Type AsiaⅠ(2005-2009) Type A (2009-2010) Type O (2010-2011) 2. Strategies for prevention and control in China 3. New technologies/products developed in LVRI

5 1. The recent outbreaks of FMD in China Serotype Asia1

From 2005 to 2009, total 46 outbreaks in 17 provinces 20 17 Outbreak Serotype Asia1 in 2009 15 Province 10 10 8 8 FMDV Asia1 strains 7 7 7 collected in 05-08 5 3 33

0 0 0 2005 2006 2007 2008 2009 2010 FMDV Asia1 strains collected in 2009 SfSurvey of epidem iol ogy i n 2009

• In 2009, serotype Asia1 reappear, 8 outbreaks in 7 provinces. • Sequence analysis suggested that all stains isolated from different province are closed to each other. • Since June 2009,there was no outbreak of serotype Asia1. Serotype A

•There was outb reak s of serotype A in Hubei province of China in Jan 2009 Outbreaks of serotype A

Date Species Susceptible Cases Location 22/01/2009 Cattle 294 58 Sunwan, Dongxihu, Wuhan, HUBEI 1 12/02/2009 Cattle 440 41 Wusi, Fen Xian, 2 30/04/2009 Cattle 413 17 Congcong, Wujing, Changzhou, JIANGSU 3 22/05/2009 Cattle 184 12 Xi'nan, Lin'gui, Guilin, GUANGXI 4 Swine 570 0 Haixing chaoyang village, Pan, Liupanshui, 22/05/2009 Cattle 78 71 GUIZHOU 5 Swine 19 19 Bingzhou, Bingcheng district, Bingzhou, 08/06/2009 Cattle 290 33 SHANDONG 6 City, Fukang City, Prefecture, 25/11/2009 ClCattle 1408 321 7 15/01/2010 Cattle 37 28 Xi'nier town, XINJIANG

02/02/2010 Cattle 44 26 Beicheng county, XINJIANG

Sheep 125 0 2009‐2010 Type A in China

2009 n=7 2010 n=2+1 Serotype O

• From 2010 to present, there are 25 ou tbrea ks in 9 provinces • O/Mya-98 and O/PanAsia are dominant serotype.

O/Mya‐98 n=20 O/PanAsia n=5 Serotype O/Mya‐98

– At present , Serotype O/Mya -98 is dominant strain to threaten Chinese livestock. – Ca ttle, p igs, sh eep can be in fec te d exper imen ta lly and by direct contact. – Epidemic frequency slowdown from Sep 2010. There are 2 outbreaks in 2011. Analysis of sequence suggested that it is related with strains isolated from southeast Asia (Thailand, Vietnam and Malaysia >97%). Serotype O/PanAsia

– It broke out in Guizhou/Tibet /Ningxia in 2011. – This stain mainlyypg infect cattle, pigs do not have typical signs. – Analysis of epidemiology suggested it came from southeast Asia, such as Vietnam, Cambodia.