DEEP DIVE

SPOTLIGHT ON SCIENTIFIC LEADERSHIP IN CENTRAL LABORATORIES

In an increasingly complex clinical development environment, access to highly-qualified PhDs who can provide insights to formulate testing strategies are instrumental in delivering seamless and efficient service.

Medpace is known for putting scientific guidance at the forefront of client relationships. Our team of PhD scientists bring specialized knowledge in a variety of testing methodologies and therapeutic clinical development including: • Biochemistry • Bioinformatics • Clinical assay development • • Coagulation • ELISA • Enzyme kinetic assays • Flow cytometry • Immunoassay systems • Ligand binding assays • Molecular • Nephelometry assays With scientific expertise embedded in • Next Gen Sequencing each study, we provide a tailored • PCR, RTPCR solution from start to finish in a way • Sanger Sequencing that isn't readily available elsewhere. • Toxicology • Translational We believe that the science of each • Urinalysis study comes first, and these leaders • Virology help facilitate that philosophy.

CENTRAL LAB Page 1 of 14 GLOBAL LEADERSHIP

Traci Turner, MD El Mustapha Chris Daniels, PhD Paul Thiam Joo Tan, PhD Santica Marcovina, Evan Stein, MD, PhD Vice-President, MRL Bahassi, PhD Director, Clinical Director, Clinical PhD, ScD FAHA Director Emeritus Operations & MARC Director, Clinical Laboratory Sciences Laboratory Services Senior Director, Laboratory Clinical Laboratory

LAB LEADERSHIP El Mustapha Bahassi, PhD Director, Clinical Laboratory, US Traci Turner, MD Vice-President, MRL Operations & MARC Dr. Bahassi brings 20 years of clinical laboratory research experience specialized in molecular oncology Dr. Traci Turner is board certified in internal to Medpace. and brings 15 years’ experience in central laboratory Experience Summary operations in development. • 20 years of experience in the direct research Experience Summary and development within a clinical laboratory • Board-certified in and is a • Served as Laboratory Director and Principal Diplomate with the American Board of Investigator for ten years with the University Clinical Lipidology of Cincinnati in both the department of • Principal Investigator for over 50 clinical trials Biology and department of Internal with lipid modifying , encompassing Medicine, division of /oncology in Phase 1-3 trials Cincinnati, OH • Has overseen the successful completion of • Developed a translational line of research where >250 lipid trials with multiple indications such he worked closely with clinical oncologists to as hypertriglyceridemia, dyslipidemia, non-FH develop new companion diagnostics using and FH hypercholesterolemia, lipodystrophies, cutting-edge genomic technologies and FCS, including providing efficacy analyses • Experienced in biomarker development in for PCSK9 inhibitors that supported acceptance liquid biopsies using both circulating tumor cells of FDA BLAs, European and global filings, and and circulating tumor DNA subsequent approvals • Strong background in molecular cell signaling • Active member of the American Heart and targeted therapies for breast, lung and Association, National Lipid Association, and brain tumors holds certification in Medical Technology from • Strong experience in immune- modalities especially CAR-T based therapies the American Society of Clinical Pathologists • Well-published in numerous peer-reviewed Education Summary scientific journals and posters • , University of Cincinnati – • Member of several organizations including the Cincinnati, OH American Association of Neurosurgeons and the • Residency, Internal Medicine, University American Association for Cancer Research Hospital – Cincinnati, OH Education Summary • Bachelor of Science in Medical Technology, • Doctor of Philosophy in Molecular Biology University of Cincinnati – Cincinnati, OH and Biotechnology • Master of Science in Molecular Biology and Biotechnology

CENTRAL LAB Page 2 of 14 Christopher Daniels, PhD Paul Thiam Joo Tan, PhD Director, Clinical Laboratory Sciences, US Director, Clinical Laboratory Services, Asia-Pac

Dr. Daniels is a PhD scientist specialized in clinical Dr. Tan is an experienced PhD scientist specialized chemistry, ligand binding assays, and biochemistry in next-generation sequencing in and and brings six years of clinical research experience oncology in clinical research. to Medpace. Experience Summary Experience Summary • 10+ years’ experience in the direct research and • Well-versed in clinical laboratory operations development within a clinical laboratory ensuring accurate, precise, and medically • Experienced in the direct management and reliable data is being generated operations of multi-country laboratories to • Experienced in CAP/CLIA, GCP, GCLP, and GLP ensure safe, cost-effective productivity and regulatory environments quality in all laboratory operations • Strong background in biomarker development in • Previously served as laboratory director ligand binding assays for laboratories in Singapore, Hong Kong, • Served as Principle Investigator in several and Indonesia pre-clinical studies • Pioneered and streamlined whole-genome • Extensive experience in the molecular and sequencing workflow for the discovery of cellular basis of heart failure novel pathogens and infectious biomarkers • Strong background in molecular cell signaling using Roche 454 Junior Next Generation and targeted therapies for cardiovascular Sequencing platform diseases • Therapeutic area experience includes next- • Well-published in several peer-reviewed generation sequencing in pathology and scientific journals and posters oncology, , immunology, blood • Member of the American Association for stem cell banking, infectious diseases, Clinical Chemistry and molecular diagnostics • Well-published in several scientific journals Education Summary • Doctor of Philosophy in Biomedical Sciences, and posters James H. Quillen College of Medicine – • Member of the College of American Pathologists Johnson City, TN Education Summary • Bachelor of Science in Sociology and Health • Doctor of Philosophy in Bioinformatics, National Sciences, East Tennessee State University – University of Singapore – Singapore Johnson City, TN • Bachelor of Applied Science National University of Singapore – Singapore

CENTRAL LAB Page 3 of 14 KOL LEADERSHIP Evan Stein, MD, PhD Director Emeritus Santica M Marcovina, PhD, ScD, FAHA Dr. Stein, a founder of Medpace's laboratories, is Senior Director, Clinical Laboratory Sciences, US considered a foremost expert on the study of lipids. Dr. Marcovina is a scientist with an international • Founded and built Medical Research reputation for her research in Lipoprotein(a), Laboratories in 1987 production of monoclonal and assay • Founded Medpace Labs in 2006 with the same development, lipoprotein and apolipoprotein method experienced team standardization and laboratory management. • Has been part of the central lab for virtually all lipid lowering agents approved and marketed Experience Summary since 1986 • 35+ years of experience in performing research • Member of the NIH NCEP Lab Committee for in academic setting methods and standardization of lab guidelines • Principal Investigator for >60 NIH-funded, • Advisor to the NIH NHLBI and CDC Lipid multi-center clinical studies primarily on Standardization branch diabetes, obesity, and diabetes complications • Served on FDA Clinical Chemistry and Clinical both in youths and adults and Phase 1-3 trials Toxicology Advisory Panel • Strong experience in assay standardization • Consults with biopharma companies on the having been the chairman of the International development programs for lipid-lowering Federation of Clinical Chemistry (IFCC) and participates in Scientific Advisory Boards working group for the standardization of apo AI and apo B, member of the American Diabetes Association working group for the standardization of insulin, member of the NIDDK consortium for the standardization of GAD-65 and IA-2 autoantibodies, and director of one of the Center for Disease Control (CDC) reference laboratories for standardization of lipids • Fellow American Heart Association, member of the American Diabetes Association, Clinical Chemistry Association, European Atherosclerosis Society, National Lipid Association, European Association for the Study of Diabetes • Author of 550 papers published in peer-reviewed Journals, >150 of which on Lipoprotein(a) Education Summary • Doctor of Philosophy in Biological Sciences with major in Biochemistry of , University of Pavia – Pavia, Italy • Doctor of Science in Sociology with major in Sociology of Communication, University of Urbino – Urbino, Italy • Bachelor in Medical Technology, School for Medical Technologists, Ospedale Umberto I – Ancona, Italy

CENTRAL LAB Page 4 of 14 MEET THE PhD TEAM

Ali Aldhumani, PhD Serena Allen, PhD Priscillia Bresler, PhD Fary Diop, PhD Eric Hugo, PhD Thomas Jun Feng Kritika Kachapati, PhD Mauricio Macossay Scientist Senior Scientist Scientist Scientist Scientist Lim, PhD Scientist Castillo, PhD Scientist Scientist

Loriana G. Mascali, PhD Nazanin Navabi, PhD Andre Olsson, PhD Phuong Nguyen, PhD Ranju Pokhrel, PhD Reddy V. Ponaka, PhD Wenyi Qin, PhD John Robbins, PhD Scientist Scientist Senior Scientist Scientist Scientist Senior Scientist, US Bioinformatics Scientist Senior Scientist

Spensor Smith, PhD Victor Van Layne Weatherford, PhD Rebecca Wilson, PhD Senior Scientist, US Puyenbroeck, PhD Scientist Senior Scientist Scientist Ali Aldhumani, PhD Serena Allen, PhD Scientist, US Senior Scientist, US

Dr. Aldhumani is a PhD scientist with experience Dr. Allen is a PhD senior scientist experienced in in biochemistry, compound screening assays, pharmacology and toxicology clinical research. computational modeling and simulations. Experience Summary Experience Summary • Experienced in research and development • Preparation of Next Generation RNA samples with direct oversight of assay validation and • RNA based in vitro assay development for implementation compound screening • Specialized in development of in-house • Experience in various biochemical techniques analytical chemistry methodologies including plasmid preparation, polymerase chain • Drove preclinical research projects to reactions (PCR), nucleic acid isolation/ successfully characterize the in-vivo preparation/purification, and pharmacology and toxicology of synthetic drug isolation/purification compounds in animal models • Prior experience in RNA based computational • Member of the American Society for modeling, simulations, and compound screening Pharmacology and Experimental Therapeutics • Publications and posters in multiple journals and the American Chemical Society and conferences • Well-published in several scientific journals Education Summary and posters • Doctor of Philosophy in Chemistry and Education Summary Biochemistry, Ohio University – Athens, OH • Doctor of Philosophy in Biomedical Sciences, • Bachelor of Science in Chemistry, Gannon East Tennessee State University – University – Erie, PA Johnson City, TN • Master of Science in Medicinal and Biological Chemistry, University of Edinburgh – Edinburgh, United Kingdom • Bachelor of Science in Pre-Medicine, the University of Tennessee at Chattanooga – Chattanooga, TN

CENTRAL LAB Page 5 of 14 Priscillia Bresler, PhD Fary Diop, PhD Scientist, Belgium Scientist, Belgium

Dr. Bresler is a PhD scientist with specialized Dr. Diop is a PhD scientist with specialized experience experience in immunology and analytical assay in hematology and clinical research. development using flow cytometry. Experience Summary Experience Summary • Well-versed in laboratory operations ensuring • Well-versed in laboratory operations ensuring accurate, precise, and medically reliable data accurate, precise, and medically reliable data • Extensive experience researching activities on • Experienced in the management of laboratory hematological diseases through a next- research and clinical development generation sequencing approach • Extensive experience investigating • Previous experience with diagnostic activities neuroinflammation on microglial cells and hiPSC on hematological diseases using molecular (human induced Pluripotent Stem Cells) biology techniques • Strong background investigating the role of • Well-published in several scientific journals microglial cells in neurodegenerative diseases at and posters UCB Pharma in Braine-L’alleud, Belgium Education Summary • Specialized experience in mucosal immunology • Doctor of Philosophy in Science and Medical by studying the development and characteristics Biotechnologies, University of Eastern of innate lymphoid cells at the Necker-Enfants Piedmont – Novara, Italy Malades Institute in Paris, France • Master of Science in Medical Biotechnologies, • Previously studied the inhibitory activity of University of Eastern Piedmont – Novara, Italy patient's neutrophils in response to Aspergillus • Bachelor of Science in Biological Sciences, Fungus at Pitié-Salpêtrière University Hospital University of Eastern Piedmont – in Paris, France Alessandria, Italy • Well-published in several scientific journals and posters • Holds a Master of Animal Experimentation certificate Education Summary • Doctor of Philosophy in Immunology, Paris Descartes University – Paris, France • Master of Science in Technologies and Health, Pierre et Marie Curie University – Paris, France • Master of Science in Molecular & Cellular Biology, Pierre et Marie Curie University – Paris, France • Master of Science in Cancerology, Paris-Sud XI University – Paris, France • Bachelor of Science in Cellular Biology & Physiology, University of Sherbrooke – Quebec, Canada

CENTRAL LAB Page 6 of 14 Eric Hugo, PhD Thomas Jun Feng Lim, PhD Scientist, US Scientist, Singapore

Dr. Hugo is a PhD scientist with over 20 years Dr. Lim is a PhD scientist with specialized experience specialized experience in adipocyte and cancer biology in skin and cancer immunobiology. clinical research and leadership roles in academia. Experience summary Experience Summary • Extensive research experience in skin • Expertise in multiple scientific areas including immunobiology and the innate cell and molecular biology, with in-depth • Discovered a novel signal transduction pathway knowledge of cancer biology in presenting cells such as dendritic cells • Participated in drug discovery using high and macrophages throughput screening with in-house • Conducted studies to identify biomarkers in developed bioassays cancer stem cells and circulating tumor cells in • Developed immunohistochemical procedures breast cancer for identifying new tumor biomarkers in breast • Designed high-parameter multi-color flow and head and neck cytometry panels to analyze leukocyte and • Extensive knowledge of adipocyte biology cancer cell populations in lymphoid and non- including human cell line creation lymphoid organs • Skilled with CRISPR-based genomic editing and • Well-published in several peer-reviewed recombinant lentivirus design and production scientific journals and numerous poster • Extensively published in multiple scientific presentations at international meetings journals and posters Education summary • Over 15 years’ experience as a grant reviewer • Doctor of Philosophy in Biological Sciences, for NIH, GACR, and ANR Nanyang Technological University – Singapore • Postdoctoral training in protein biophysics at • Bachelor of Science in Biological Sciences, Washington University School of Medicine Nanyang Technological University – Singapore • Postdoctoral training in , metabolism and cancer biology at the University Kritika Kachapati, PhD of Cincinnati College of Medicine Scientist, US • Member of the American Society of Biochemistry and Molecular Biology Dr. Kachapati is a PhD scientist with specialized Education Summary experience in immunology and clinical research. • Doctor of Philosophy in Molecular Genetics, Experience Summary The Ohio State University – Columbus, OH • Well-versed in laboratory operations ensuring • Master of Science in Microbiology, The Ohio accurate, precise, and medically reliable data State University – Columbus, OH • Experienced in the management of laboratory • Bachelor of Science in Biology, Northern research and clinical development Kentucky University – Highland Heights, KY • Previously conducted research on the role of soluble CD137 producing T regulatory cells mediated diabetes suppression at The University of Cincinnati in Cincinnati, OH • Well-published in several scientific journals and posters Education Summary • Post-Doctorate Degree in Immunology, University of Cincinnati – Cincinnati, OH • Doctor of Philosophy in Immunology, University of Pittsburgh – Pittsburgh, PA • Bachelor of Science in Biology, Hood College – Frederick, MD

CENTRAL LAB Page 7 of 14 Mauricio Macossay Castillo, PhD Loriana G. Mascali, PhD Scientist, Belgium Scientist, Belgium

Dr. Macossay Castillo is a PhD scientist with experience Dr. Mascali is a PhD scientist with specialized in fundamental research, as well as in the hospital experience in endocrinology, neuro-immunology and clinical laboratory and clinical research. analytical assay development using flow cytometry. Experience Summary Experience Summary • Experienced in the study of the relationship • Expertise in multiple scientific areas including between protein structure and function through cell and molecular biology, with in-depth bioinformatics approaches knowledge of neuro-immunology • Well-versed in several areas of the hospital • Well-versed in laboratory operations ensuring clinical laboratory, such as hematology, accurate, precise, and medically reliable data coagulation, microscopy, clinical chemistry, • Experienced in the management of laboratory urinalysis, immunoassay, nucleic acid extraction, research viral load, and T-cell count • Strong background investigating the role of • Participated in the development of a molecular Tregs cells in brain diseases test for the detection of viremia and genotyping • Developed immunohistochemical procedures of the hepatitis C virus for identifying immune cells activation and • Well-published in several scientific journals interaction in brain diseases and posters • Skilled with CRISPR-based genomic editing Education Summary • Strong background in molecular cell signaling • Doctor of Philosophy in Bioengineering and targeted therapies for T1DM and T2DM Sciences, Vrije Universiteit Brussel – • Well-published in numerous peer-reviewed Brussels, Belgium scientific journals and posters • Master of Science in Molecular Biology, Vrije Education Summary Universiteit Brussel – Brussels, Belgium • Doctor of Philosophy in Endocrinological • Bachelor’s Degree in , Chemistry and Science, University of Catania – Catania, Italy Biology, Universidad Autonoma de Yucatan – • Master of Science in Cellular and Molecular Merida, Mexico Biology, University of Catania – Catania, Italy • Bachelor of Science in Biology, University of Catania – Catania, Italy • Master of Animal Experimentation certificate, KU Leuven – Leuven, Belgium

CENTRAL LAB Page 8 of 14 Nazanin Navabi, PhD Andre Olsson, PhD Scientist, US Senior Scientist, US

Dr. Navabi is a PhD scientist with specialized Dr. Olsson is an experienced PhD senior scientist experience in , immunobiology, and specialized in experimental hematology as well as clinical research. immunobiology. Experience Summary Experience Summary • Well-versed in laboratory operations ensuring • Extensive experience in multiple scientific areas accurate, precise, and medically reliable data including cell and molecular biology with focus • Extensive experience in the management of on myeloid cell fate laboratory research and clinical development • Well versed in developing multiparametric flow • Previously studied the interaction between cytometry assays for detection of hematopoietic host-pathogens in gastrointestinal tract in cell populations the Department of Gastroenterology at • Previously combined flow cytometry sorting Cincinnati Children’s Hospital Medical Center with single cell RNA-seq and single cell ATAC • Completed a three-year clinical research seq for novel discovery of cell lineage decisions fellowship program in the Department of • Well-published in top tier scientific journals and Immunobiology at the Cincinnati Children’s have made several poster and oral presentations Hospital Medical Center at international meetings in his field • Well-published in numerous peer-reviewed Education Summary scientific journals and several poster and oral • Doctor of Philosophy in Experimental presentations in international conferences in Hematology, Lund University – Lund, Sweden her field • Master of Science in Molecular Biology, Lund Education Summary University – Lund, Sweden • Doctor of Philosophy in Medicine, Gothenburg University – Gothenburg, Sweden • Master of Science in Biology, Gothenburg University – Gothenburg, Sweden • Bachelor of Science in Applied Chemistry, University of Mazandaran – Babolsar, Iran

CENTRAL LAB Page 9 of 14 Phuong Nguyen, PhD Ranju Pokhrel, PhD Scientist, US Scientist, US

Dr. Nguyen is a PhD scientist with specialized Dr. Pokhrel is a PhD scientist with specialized experience in molecular pharmacology, cancer biology, experience in biochemistry, analytical chemistry and and cancer immunobiology. assay development. Experience Summary Experience Summary • Extensive experiences in multiple scientific • Well-versed in laboratory operations ensuring areas including molecular pharmacology and accurate, precise, and medically reliable data molecular biology with a focus on cancer biology • Expertise in basic microbiology and molecular and cancer immunobiology biology techniques • Well versed in designing and conducting • Previous experience with protein purification polychromatic- flow cytometry assays for and characterization, peptide synthesis and immunotyping of T cells, B cells, plasma cells purification and designing and development including CD4, CD8, and Treg cells of binding assays • Expertise in investigating the role of tumor- • Well-published in several scientific journals intrinsic Cdc42, an oncogene in regulation of and posters T cells activity, which involves in tumor Education Summary immunogenicity in the Department of • Doctor of Philosophy in Chemistry and Hematology, Cancer and Blood Diseases at Biochemistry, Ohio University – Athens OH Cincinnati Children’s Hospital Medical Center • Master of Science in Microbiology, Tribhuwan • Well-published in top reputative scientific University – Kathmandu, Nepal journals and several poster presentations at international meetings in her field Education Summary • Doctor of Philosophy in Pharmaceutical Chemistry, Chosun University – Kwangju, South Korea • Master of Pharmacy in Molecular Pharmacology, Chosun University – Kwangju, South Korea • Bachelor of Pharmacy, Hanoi University of Pharmacy – Hanoi, Vietnam

CENTRAL LAB Page 10 of 14 Reddy V Ponaka, PhD Wenyi Qin, PhD Senior Scientist, US Bioinformatics Scientist, US

Dr. Ponaka is a PhD senior scientist experienced Dr. Qin is a PhD scientist with specialized experienced in genomics reagent development, lean six sigma in bioinformatics and clinical research. methodologies, molecular diagnostic assay design Experience Summary and development for infectious disease diagnosis and • Well-versed in the analyzation of experimental human genotyping assays. data produced by next-generation sequencing Experience Summary • Developed novel data integration statistical • Expertise in extraction, extraction free and framework in identifying disease-related amplification-based sample preparation and pathways methods from different types of clinical • Well-published in several scientific journals samples for downstream molecular and posters diagnostic applications • Previous experience with the Yale University • Design, verification, and optimization of School of Medicine as a Postdoctoral Research Combinatorial Pharmacogenomics assays using Associate, Department of Genetics multiplex‐PCR, MassARRAY detection along Education Summary with capillary electrophoresis systems • Doctor of Philosophy in Bioinformatics, the • Worked on the development of the several University of Illinois at Chicago – Chicago, IL molecular assays that successfully received • Bachelor of Science in Biological Science, Fudan US-IVD/CE-IVD/EUA approval, ASR or RUO University – Shanghai, China status for tests including C. difficile, Group B Streptococci, Group A Streptococci, M. pneumoniae, HSV 1&2, Chlamydia and Spenser Smith, PhD Scientist, US Gonorrhea, Malaria, Borrelia (Lyme disease), Babesia, Kingella kingae, H. pylori and Dr. Smith is a PhD scientist specialized in skeletal, SARS-CoV-2 cellular, and molecular biology. • Designed and developed a multiplex nucleic acid amplification assay for the detection Experience Summary of GI based on both allele- • Extensive experience in molecular and specific PCR, and fluorescent LAMP along with cell signaling regulation, including drug‐resistance determination using ambient microRNAs, mRNA stability, and stored reagents post-transcriptional regulation • Led multiple projects for the development • Strong background in assay development, and of PCR and DNA sequencing related genomic experimental optimization and validation. reagents and DNA polymerases for • Well versed in genetic experimental techniques Pharmaceutical and Life science industry and modifications customers. Evaluated different isothermal • Experienced in several molecular amplification technologies for diagnostic and assays, including Polymerase Chain Reaction research applications. Led the ambient (PCR), RNA sequencing, plasmid and viral temperature stable genomic reagent projects design and cloning, protein purification, using lyophilization methods immunohistochemistry, RNA- immunoprecipitation, and reporter assays Education Summary • Well published in several scientific journals and • Doctor of Philosophy from Alabama A&M numerous poster and oral presentations at University, Huntsville, AL. Studies focused international meetings in his field on DNA fingerprinting using Restriction Fragment Length Polymorphisms (RFLP) and Education Summary PCR based markers • Doctor of Philosophy in Biomedical Science, • Master of Science in Microbiology, Sri University of Connecticut – Farmington, CT Krishnadevaraya University, A.P., India • Bachelor of Arts in Biology and History, The College of Idaho – Caldwell, ID

CENTRAL LAB Page 11 of 14 Victor Van Puyenbroeck, PhD John Robbins, PhD Scientist, Belgium Senior Scientist, US

Dr. Van Puyenbroeck is an experienced PhD Dr. Robbins is an experienced PhD scientist specialized scientist specialized in virology and in clinical assay development, enzyme kinetics, protein clinical research. dynamics, molecular biology, ELISA, hematology, Experience Summary coagulation, and urinalysis. • Well-versed in laboratory operations to verify Experience Summary that accurate, precise, and medically reliable • Extensive experience in the research data are being generated and development of assay validation and • Experienced in conducting DNA vaccine method implementation development and validation, upscaling • Previously conducted research aimed at the throughput of antiviral drug screening methods development of novel biocatalysts by • Previously worked at KU Leuven in the complementing data-driven protein Translational Research Laboratory for Virology engineering processes with traditional and Chemotherapy mechanistic and kinetic enzymology • Well-published in several scientific journals techniques and analyses and posters • Registered Agent with the United States Education Summary Patent and Trademark Office • Doctor of Philosophy in Biomedical Sciences, • Member of the American Chemical Society, KU Leuven – Leuven, Belgium American Society of Biochemistry and • Master of Science in Bioscience Engineering/ Molecular Biology, and National Association for Cell and Technology, KU Leuven – Patent Practitioners Leuven, Belgium Education Summary • Doctor of Philosophy in Biochemistry, Auburn University – Auburn, AL • Bachelor of Science in Chemistry, Hampden- Sydney College – Hampden-Sydney, VA

CENTRAL LAB Page 12 of 14 Layne Weatherford, PhD Rebecca Wilson, PhD Scientist, US Senior Scientist, US

Dr. Weatherford is a PhD scientist experienced in Dr. Wilson is an experienced PhD scientist immunology and cancer biology basic and translational specialized in immunology and nephelometry assays in research. clinical research. Experience Summary Experience Summary • Broad experience in cell and molecular biology • Extensive experience in the research with a focus on mechanisms related to and development of validated assays in carcinogenesis and resistance to therapy cGMP environment • Experienced in performing translational research • Well-versed in the design and formulation of using primary tumor cells and analyzing pharmaceutical and cosmetic products for biomarker data from cancer clinical application clinical trials • Experienced in several types of analytical • Strong background in molecular signaling chemistry techniques as well as molecular pathways dysregulated in cancers assays, including Polymerase Chain Reaction • Postdoctoral training in cancer biology at (PCR), cloning, and protein purification Vanderbilt University School of Medicine • Well-published in several scientific journals • Postdoctoral training in immunology and and posters cancer biology at University of Cincinnati • Member of the American Chemistry Society College of Medicine Education Summary Education Summary • Doctor of Philosophy in Biomedical Sciences, • Doctor of Philosophy in Cancer Biology, Wayne East Tennessee State University – State University – Detroit, MI Johnson City, TN • Bachelor of Science in Biology, Michigan State • Bachelor of Science in Biological Sciences, University – East Lansing, MI University of Cincinnati – Cincinnati, OH

CENTRAL LAB Page 13 of 14 GLOBAL CENTRAL LABORATORIES Medpace provides customized, high-quality central laboratory services to pharmaceutical and biotech clinical development industries. Our four wholly- owned laboratories offer full-service support to six continents for phase I-IV studies in a wide range of complexity and scale. Our standardized testing platforms, comprehensive test menu, scientific leadership, and stellar project management teams allow Medpace to set up fully customized projects for our clients.

Central Laboratories Highlights: • Serving some of the world’s largest, most complex clinical trials • Extensive capacity and global scalability in state-of-the-art facilities • Fully-harmonized, high throughput instrumentation delivering high quality data • On-time data transfers • Biomarker development, validation and FULL-SERVICE CLINICAL DEVELOPMENT PD analysis Medpace is a scientifically-driven, global, full-service • Industry-leading quick validation timelines ® clinical contract research organization providing • Web-based data portal – ClinTrak Lab – Phase I-IV clinical development services to the provides seamless data management delivered biotechnology, pharmaceutical and medical device in a single integrated global database industries. Medpace’s mission is to accelerate the global development of safe and effective medical therapeutics through its high-science and disciplined operating approach that leverages local regulatory and deep therapeutic expertise across all major areas including oncology, , metabolic disease, endocrinology, central nervous system and anti-viral and anti-infective.

SUPPORTING CLINICAL TRIALS IN 70+ COUNTRIES

MRL-0007-R0921